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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004339", "map_id": "WBGene00004339", "name": "rfc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27474", "map_id": "Q27474", "name": "lig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002985", "map_id": "WBGene00002985", "name": "lig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19366", "map_id": "Q19366", "name": "POLD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008722", "map_id": "WBGene00008722", "name": "POLD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y97", "map_id": "Q95Y97", "name": "rpa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019767", "map_id": "WBGene00019767", "name": "rpa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02115", "map_id": "O02115", "name": "pcn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003955", "map_id": "WBGene00003955", "name": "pcn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19196", "map_id": "Q19196", "name": "pole-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017237", "map_id": "WBGene00017237", "name": "pole-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44175", "map_id": "O44175", "name": "rfc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004338", "map_id": "WBGene00004338", "name": "rfc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62218", "map_id": "O62218", "name": "pole-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009368", "map_id": "WBGene00009368", "name": "pole-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21730", "map_id": "Q21730", "name": "POLD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011016", "map_id": "WBGene00011016", "name": "POLD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53016", "map_id": "P53016", "name": "rfc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004340", "map_id": "WBGene00004340", "name": "rfc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18841", "map_id": "Q18841", "name": "rfc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004337", "map_id": "WBGene00004337", "name": "rfc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34429", "map_id": "P34429", "name": "RFC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018409", "map_id": "WBGene00018409", "name": "RFC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90829", "map_id": "P90829", "name": "POLD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008645", "map_id": "WBGene00008645", "name": "POLD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22798", "map_id": "Q22798", "name": "POLE3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020823", "map_id": "WBGene00020823", "name": "POLE3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646044", "map_id": "none", "name": "LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604733", "map_id": "none", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30555", "map_id": "CHEBI:16516", "name": "dNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604730", "map_id": "none", "name": "APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N3T2", "map_id": "Q9N3T2", "name": "crn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000794", "map_id": "WBGene00000794", "name": "crn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604726", "map_id": "none", "name": "APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113541", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604741", "map_id": "none", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604737", "map_id": "none", "name": "APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598275", "map_id": "Q27474", "name": "lig-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10639098", "map_id": "none", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639084", "map_id": "none", "name": "Homologues of p-S407,Y641-STAT6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NAD6", "map_id": "Q9NAD6", "name": "phospho-sta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013111", "map_id": "WBGene00013111", "name": "phospho-sta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20977", "map_id": "Q20977", "name": "phospho-sta-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010251", "map_id": "WBGene00010251", "name": "phospho-sta-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639086", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639106", "map_id": "none", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639104", "map_id": "none", "name": "Homologues of p-S407-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_113592", "map_id": "CHEBI:30616", "name": "ATP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29370", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10639096", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639094", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10659999", "map_id": "none", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29438", "map_id": "CHEBI:37565", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10615247", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_29420", "map_id": "CHEBI:58189", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q18246", "map_id": "Q18246", "name": "rap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004307", "map_id": "WBGene00004307", "name": "rap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615172", "map_id": "none", "name": "RAP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659994", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P29355", "map_id": "P29355", "name": "sem-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004774", "map_id": "WBGene00004774", "name": "sem-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NHC3", "map_id": "Q9NHC3", "name": "ced-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000416", "map_id": "WBGene00000416", "name": "ced-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZX7", "map_id": "H2KZX7", "name": "RAPGEF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021320", "map_id": "WBGene00021320", "name": "RAPGEF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XA9", "map_id": "Q95XA9", "name": "gap-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021238", "map_id": "WBGene00021238", "name": "gap-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ7", "map_id": "Q9XVQ7", "name": "MET", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008711", "map_id": "WBGene00008711", "name": "MET", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDJ4", "map_id": "G5EDJ4", "name": "phospho-soc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004928", "map_id": "WBGene00004928", "name": "phospho-soc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659992", "map_id": "none", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657701", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617312", "map_id": "none", "name": "CRK, CRKL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659990", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659996", "map_id": "none", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607816", "map_id": "H2KZX7", "name": "RAPGEF1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10660005", "map_id": "none", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660001", "map_id": "none", "name": "(DOCK7)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20487", "map_id": "Q20487", "name": "DOCK6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018520", "map_id": "WBGene00018520", "name": "DOCK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660003", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660008", "map_id": "none", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635280", "map_id": "none", "name": "RAC1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03206", "map_id": "Q03206", "name": "ced-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ced-10", "map_id": "ced-10", "name": "ced-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605399", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614891", "map_id": "none", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10614881", "map_id": "Q965F9", "name": "par-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003917", "map_id": "WBGene00003917", "name": "par-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10614552", "map_id": "Q965F9", "name": "phospho-par-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10614888", "map_id": "Q9N3Q4", "name": "phospho-atm-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000227", "map_id": "WBGene00000227", "name": "atm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614556", "map_id": "none", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10614554", "map_id": "Q965F9", "name": "phospho-par-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10614561", "map_id": "none", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597908", "map_id": "P0CG71", "name": "ubq-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006727", "map_id": "WBGene00006727", "name": "ubq-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614558", "map_id": "none", "name": "ubiquitinated phospho-COP1(ser-387)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965F9", "map_id": "Q965F9", "name": "par-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG71", "map_id": "P0CG71", "name": "ubq-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598360", "map_id": "none", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598355", "map_id": "G5EEJ2", "name": "cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000517", "map_id": "WBGene00000517", "name": "phospho-cki-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598298", "map_id": "none", "name": "CCNE:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O01501", "map_id": "O01501", "name": "cye-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000871", "map_id": "WBGene00000871", "name": "cye-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61847", "map_id": "O61847", "name": "cdk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019362", "map_id": "WBGene00019362", "name": "cdk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2M5", "map_id": "Q9U2M5", "name": "cyd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000870", "map_id": "WBGene00000870", "name": "cyd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598357", "map_id": "none", "name": "Cyclin E:CDK2:CDKN1A,CDKN1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EEJ2", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10609600", "map_id": "none", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607975", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2L0L4", "map_id": "H2L0L4", "name": "CCNF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020461", "map_id": "WBGene00020461", "name": "CCNF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34638", "map_id": "P34638", "name": "cya-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000863", "map_id": "WBGene00000863", "name": "cya-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609593", "map_id": "none", "name": "Cyclin A:Cdk2:p21/p27 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614563", "map_id": "none", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598108", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44156", "map_id": "O44156", "name": "pas-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003927", "map_id": "WBGene00003927", "name": "pas-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61792", "map_id": "O61792", "name": "rpn-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004464", "map_id": "WBGene00004464", "name": "rpn-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22253", "map_id": "Q22253", "name": "rpn-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004465", "map_id": "WBGene00004465", "name": "rpn-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91477", "map_id": "P91477", "name": "pbs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003950", "map_id": "WBGene00003950", "name": "pbs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76577", "map_id": "O76577", "name": "rpn-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004467", "map_id": "WBGene00004467", "name": "rpn-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46502", "map_id": "P46502", "name": "rpt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004503", "map_id": "WBGene00004503", "name": "rpt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90868", "map_id": "P90868", "name": "pbs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003953", "map_id": "WBGene00003953", "name": "pbs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17071", "map_id": "O17071", "name": "rpt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004504", "map_id": "WBGene00004504", "name": "rpt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18787", "map_id": "Q18787", "name": "rpt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004501", "map_id": "WBGene00004501", "name": "rpt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62102", "map_id": "O62102", "name": "pbs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003948", "map_id": "WBGene00003948", "name": "pbs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20058", "map_id": "Q20058", "name": "PSMD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009445", "map_id": "WBGene00009445", "name": "PSMD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTT9", "map_id": "Q9XTT9", "name": "rpt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004506", "map_id": "WBGene00004506", "name": "rpt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20938", "map_id": "Q20938", "name": "rpn-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004462", "map_id": "WBGene00004462", "name": "rpn-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34286", "map_id": "P34286", "name": "pbs-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003952", "map_id": "WBGene00003952", "name": "pbs-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76371", "map_id": "O76371", "name": "rpt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004505", "map_id": "WBGene00004505", "name": "rpt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95008", "map_id": "Q95008", "name": "pas-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003926", "map_id": "WBGene00003926", "name": "pas-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966I8", "map_id": "Q966I8", "name": "pbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003947", "map_id": "WBGene00003947", "name": "pbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ7", "map_id": "Q95PZ7", "name": "PSME3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013435", "map_id": "WBGene00013435", "name": "PSME3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61742", "map_id": "O61742", "name": "rpn-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004466", "map_id": "WBGene00004466", "name": "rpn-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17971", "map_id": "Q17971", "name": "PSME4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007588", "map_id": "WBGene00007588", "name": "PSME4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUV0", "map_id": "Q9XUV0", "name": "pbs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003951", "map_id": "WBGene00003951", "name": "pbs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95005", "map_id": "Q95005", "name": "pas-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003925", "map_id": "WBGene00003925", "name": "pas-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", 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}, { "id": "WBGene00016623", "map_id": "WBGene00016623", "name": "psmd-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23237", "map_id": "Q23237", "name": "pbs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003949", "map_id": "WBGene00003949", "name": "pbs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZH5", "map_id": "Q9GZH5", "name": "rpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004458", "map_id": "WBGene00004458", "name": "rpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19324", "map_id": "Q19324", "name": "rpn-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004461", "map_id": "WBGene00004461", "name": "rpn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45398", "map_id": "O45398", "name": "PSMD10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009064", "map_id": "WBGene00009064", "name": "PSMD10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20585", "map_id": "Q20585", "name": "rpn-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004463", "map_id": 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"complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004468", "map_id": "WBGene00004468", "name": "rpn-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27488", "map_id": "Q27488", "name": "pas-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003923", "map_id": "WBGene00003923", "name": "pas-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17586", "map_id": "O17586", "name": "pas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003922", "map_id": "WBGene00003922", "name": "pas-1", "type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_display": "none" }, { "id": "WBGene00004473", "map_id": "WBGene00004473", "name": "rps-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19869", "map_id": "Q19869", "name": "rpl-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004440", "map_id": "WBGene00004440", "name": "rpl-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U332", "map_id": "Q9U332", "name": "rpl-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004445", "map_id": "WBGene00004445", "name": "rpl-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWS4", "map_id": "Q9XWS4", "name": "rpl-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004444", "map_id": "WBGene00004444", "name": "rpl-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49181", "map_id": "P49181", "name": "rpl-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004450", "map_id": "WBGene00004450", "name": "rpl-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQF3", "map_id": "Q8WQF3", "name": "smg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004882", "map_id": "WBGene00004882", "name": "smg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U302", "map_id": "Q9U302", "name": "pab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003902", "map_id": "WBGene00003902", "name": "pab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01802", "map_id": "O01802", "name": "rpl-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004418", "map_id": "WBGene00004418", "name": "rpl-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47991", "map_id": "P47991", "name": "rpl-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004417", "map_id": "WBGene00004417", "name": "rpl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44480", "map_id": "O44480", "name": "rpl-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004432", "map_id": "WBGene00004432", "name": "rpl-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62301", "map_id": "O62301", "name": "smg-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010551", "map_id": "WBGene00010551", "name": "smg-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91374", "map_id": "P91374", "name": "rpl-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004427", "map_id": "WBGene00004427", "name": "rpl-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQA8", "map_id": "Q8WQA8", "name": "rps-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004489", "map_id": "WBGene00004489", "name": "rps-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49029", "map_id": "P49029", "name": "mag-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003123", "map_id": "WBGene00003123", "name": "mag-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27389", "map_id": "Q27389", "name": "rpl-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004428", "map_id": "WBGene00004428", "name": "rpl-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEN6", "map_id": "Q9NEN6", "name": "rps-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004475", "map_id": "WBGene00004475", "name": "rps-6", "type": "gene_component", "sub_type": 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18667", "compartment_display": "microtubule organizing center" }, { "id": "species_10665330", "map_id": "none", "name": "Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18667", "compartment_display": "microtubule organizing center", "complex": "true" }, { "id": "O18154", "map_id": "O18154", "name": "tba-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006533", "map_id": "WBGene00006533", "name": "tba-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDD4", "map_id": "G5EDD4", "name": "tba-4", "type": "complex_component", 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000962", "map_id": "WBGene00000962", "name": "dhc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTJ8", "map_id": "Q7YTJ8", "name": "dlc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012425", "map_id": "WBGene00012425", "name": "dlc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11083", "map_id": "Q11083", "name": "Misfolded CETN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED34", "map_id": "G5ED34", "name": "dli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001007", "map_id": "WBGene00001007", "name": "dli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L2E8", "map_id": "H2L2E8", "name": "tba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006528", "map_id": "WBGene00006528", "name": "tba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0N8", "map_id": "H2L0N8", "name": "arl-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021349", "map_id": "WBGene00021349", "name": "arl-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12456", "map_id": "P12456", "name": "mec-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003171", "map_id": "WBGene00003171", "name": "mec-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34690", "map_id": "P34690", "name": "tba-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006529", "map_id": "WBGene00006529", "name": "tba-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21557", "map_id": "Q21557", "name": "dlc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010888", "map_id": "WBGene00010888", "name": "dlc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41937", "map_id": "P41937", "name": "tbb-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006538", "map_id": "WBGene00006538", "name": "tbb-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q65XS9", "map_id": "Q65XS9", "name": "dlc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043067", "map_id": "WBGene00043067", "name": "dlc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90994", "map_id": "P90994", "name": "djr-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015184", "map_id": "WBGene00015184", "name": "djr-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QV2", "map_id": "Q95QV2", "name": "cft-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000477", "map_id": "WBGene00000477", "name": "cft-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17921", "map_id": "O17921", "name": "tbb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006536", "map_id": "WBGene00006536", "name": "tbb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF01", "map_id": "G5EF01", "name": "tbb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006539", "map_id": "WBGene00006539", "name": "tbb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0AAC1", "map_id": "A0AAC1", "name": "dlc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012424", "map_id": "WBGene00012424", "name": "dlc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U266", "map_id": "Q9U266", "name": "hda-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001838", "map_id": "WBGene00001838", "name": "hda-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED37", "map_id": "G5ED37", "name": "osm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003885", "map_id": "WBGene00003885", "name": "osm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665336", "map_id": "none", "name": "Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10616991", "map_id": "none", "name": "Microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10656088", "map_id": "none", "name": "Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665685", "map_id": "none", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665651", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10642212", "map_id": "Q17746", "name": "SQSTM1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015552", "map_id": "WBGene00015552", "name": "SQSTM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665653", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q17746", "map_id": "Q17746", "name": "SQSTM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642254", "map_id": "none", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642201", "map_id": "Q18746", "name": "K48polyUb-MTERFD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00008236", "map_id": "WBGene00008236", "name": "K48polyUb-MTERFD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642207", "map_id": "Q21752", "name": "vdac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00019900", "map_id": "WBGene00019900", "name": "vdac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642195", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00001509", "map_id": "WBGene00001509", "name": "fzo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642193", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10642214", "map_id": "none", "name": "K48polyUB Mitophagy Substrates:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q21752", "map_id": "Q21752", "name": "vdac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23424", "map_id": "Q23424", "name": "fzo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18746", "map_id": "Q18746", "name": "K48polyUb-MTERFD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665641", "map_id": "none", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10642221", "map_id": "Q23536", "name": "lgg-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002981", "map_id": "WBGene00002981", "name": "lgg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665675", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10665677", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q23536", "map_id": "Q23536", "name": "lgg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665657", "map_id": "none", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10665655", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10662842", "map_id": "none", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10662838", "map_id": "none", "name": "p-S17-FUNDC1:LC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q22252", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011528", "map_id": "WBGene00011528", "name": "phospho-fndc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642246", "map_id": "none", "name": "ATG5:ATG12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q3V5I7", "map_id": "Q3V5I7", "name": "atg-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022152", "map_id": "WBGene00022152", "name": "atg-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10931", "map_id": "Q10931", "name": "lgg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002982", "map_id": "WBGene00002982", "name": "lgg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662840", "map_id": "none", "name": "p-S17-FUNDC1:LC3:ATG5:ATG12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10642225", "map_id": "none", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642219", "map_id": "Q23536", "name": "lgg-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10642223", "map_id": "none", "name": "LC3:K48polyUB Mitophagy Substrates:SQSTM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665671", "map_id": "none", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10665643", "map_id": "Q9N3Q4", "name": "atm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10665659", "map_id": "none", "name": "ATM:PEX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_1250243", "map_id": "CHEBI:26523", "name": "ROS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10662844", "map_id": "none", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661490", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10661493", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10661460", "map_id": "Q22252", "name": "fndc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10661471", "map_id": "none", "name": "Homologues of ULK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A3P6NNZ8", "map_id": "A0A3P6NNZ8", "name": "ULK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020324", "map_id": "WBGene00020324", "name": "ULK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23023", "map_id": "Q23023", "name": "unc-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006786", "map_id": "WBGene00006786", "name": "unc-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665228", "map_id": "none", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665220", "map_id": "none", "name": "Misfolded Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665224", "map_id": "none", "name": "Ub:UBE2N:UBE2V1:PRKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45495", "map_id": "O45495", "name": "uev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006730", "map_id": "WBGene00006730", "name": "uev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XX0", "map_id": "Q95XX0", "name": "ubc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006708", "map_id": "WBGene00006708", "name": "ubc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665226", "map_id": "none", "name": "Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10642252", "map_id": "none", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10642234", "map_id": "Q09298", "name": "pink-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "WBGene00017137", "map_id": "WBGene00017137", "name": "pink-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642230", "map_id": "Q09298", "name": "pink-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10665284", "map_id": "none", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665282", "map_id": "none", "name": "Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661481", "map_id": "none", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661463", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10661478", "map_id": "Q09422", "name": "pgam-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00019941", "map_id": "WBGene00019941", "name": "pgam-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661465", "map_id": "none", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612071", "map_id": "none", "name": "Casein kinase II", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P18334", "map_id": "P18334", "name": "kin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002191", "map_id": "WBGene00002191", "name": "kin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28548", "map_id": "P28548", "name": "kin-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002196", "map_id": "WBGene00002196", "name": "kin-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665286", "map_id": "none", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665256", "map_id": "none", "name": "PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10642258", "map_id": "none", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10642256", "map_id": "Q09298", "name": "pink-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10665683", "map_id": "none", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10661487", "map_id": "none", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661484", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10610070", "map_id": "G5EE56", "name": "src-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00005077", "map_id": "WBGene00005077", "name": "src-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665320", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665316", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665318", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6:Dynein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665681", "map_id": "none", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661473", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10646604", "map_id": "none", "name": "Homologues of ULK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624305", "map_id": "none", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624302", "map_id": "none", "name": "O-Acetylcholine bound to Acetylcholine receptor", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KZY7", "map_id": "H2KZY7", "name": "lgc-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022283", "map_id": "WBGene00022283", "name": "lgc-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N587", "map_id": "Q9N587", "name": "unc-63", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006797", "map_id": "WBGene00006797", "name": "unc-63", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_264643", "map_id": "CHEBI:15355", "name": "AcCho", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q93323", "map_id": "Q93323", "name": "lgc-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007903", "map_id": "WBGene00007903", "name": "lgc-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624483", "map_id": "none", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10624300", "map_id": "none", "name": "Highly sodium permeable nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10656521", "map_id": "none", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_10656517", "map_id": "Q9BL29", "name": "TMEM55B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "WBGene00022167", "map_id": "WBGene00022167", "name": "TMEM55B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656519", "map_id": "Q9BL29", "name": "TMEM55B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10656524", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_6810412", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113550", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_6810408", "map_id": "CHEBI:16500", "name": "PI5P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10656818", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10656815", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9BL73", "map_id": "Q9BL73", "name": "ppk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004088", "map_id": "WBGene00004088", "name": "ppk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611022", "map_id": "none", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611013", "map_id": "Q18846", "name": "rskn-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00008311", "map_id": "WBGene00008311", "name": "rskn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611019", "map_id": "Q18846", "name": "phospho-rskn-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10607257", "map_id": "none", "name": "p-p38 MAPK alpha/beta", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MXI4", "map_id": "Q8MXI4", "name": "phospho-pmk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004056", "map_id": "WBGene00004056", "name": "phospho-pmk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44514", "map_id": "O44514", "name": "phospho-pmk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004057", "map_id": "WBGene00004057", "name": "phospho-pmk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17446", "map_id": "Q17446", "name": "phospho-pmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004055", "map_id": "WBGene00004055", "name": "phospho-pmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664813", "map_id": "none", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607886", "map_id": "none", "name": "p-T,Y MAPK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P39745", "map_id": "P39745", "name": "mpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003401", "map_id": "WBGene00003401", "name": "mpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PDY6", "map_id": "U4PDY6", "name": "MAPK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019665", "map_id": "WBGene00019665", "name": "MAPK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611039", "map_id": "none", "name": "p-T,Y MAPK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664806", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664792", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q20655", "map_id": "Q20655", "name": "ftt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001502", "map_id": "WBGene00001502", "name": "ftt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10664", "map_id": "Q10664", "name": "phospho-mek-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003186", "map_id": "WBGene00003186", "name": "phospho-mek-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41932", "map_id": "P41932", "name": "par-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003920", "map_id": "WBGene00003920", "name": "par-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07292", "map_id": "Q07292", "name": "lin-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003030", "map_id": "WBGene00003030", "name": "lin-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664801", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10664790", "map_id": "none", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10618746", "map_id": "none", "name": "MAPKs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664786", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10647064", "map_id": "none", "name": "MAP2K homo/heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664788", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10612228", "map_id": "none", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10605404", "map_id": "Q22038", "name": "rho-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004357", "map_id": "WBGene00004357", "name": "rho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612226", "map_id": "none", "name": "PIP3:RhoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22038", "map_id": "Q22038", "name": "rho-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664854", "map_id": "none", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10664849", "map_id": "Q18955", "name": "unc-120", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006844", "map_id": "WBGene00006844", "name": "phospho-unc-120", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664852", "map_id": "Q18955", "name": "phospho-unc-120", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10664841", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G4S4W1", "map_id": "G4S4W1", "name": "SGK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016980", "map_id": "WBGene00016980", "name": "SGK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2PJ68", "map_id": "Q2PJ68", "name": "sgk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004789", "map_id": "WBGene00004789", "name": "sgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611305", "map_id": "none", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611144", "map_id": "D0Z5N1", "name": "crh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000793", "map_id": "WBGene00000793", "name": "phospho-crh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611147", "map_id": "D0Z5N1", "name": "phospho-crh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611302", "map_id": "none", "name": "Homologues of p-T222,S272-MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q965G5", "map_id": "Q965G5", "name": "phospho-mak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007007", "map_id": "WBGene00007007", "name": "phospho-mak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21360", "map_id": "Q21360", "name": "phospho-mak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010681", "map_id": "WBGene00010681", "name": "phospho-mak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664811", "map_id": "none", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10664808", "map_id": "none", "name": "RAP1:GTP:B-Raf complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10611033", "map_id": "none", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611029", "map_id": "G5EBT1", "name": "phospho-sma-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004859", "map_id": "WBGene00004859", "name": "sma-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611031", "map_id": "G5EBT1", "name": "phospho-sma-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611296", "map_id": "none", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611290", "map_id": "D0Z5N1", "name": "crh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611293", "map_id": "D0Z5N1", "name": "phospho-crh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611307", "map_id": "none", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10664803", "map_id": "none", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618752", "map_id": "none", "name": "p-T,Y MAPKs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647089", "map_id": "none", "name": "p-2S MAP2K homo/heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664844", "map_id": "none", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10607457", "map_id": "none", "name": "C3G stimulates nucleotide exchange on Rap1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607452", "map_id": "none", "name": "Rap1-GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607454", "map_id": "none", "name": "Rap1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607443", "map_id": "none", "name": "Active TrkA receptor:Phospho-ARMS:Crk complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGK5", "map_id": "G5EGK5", "name": "phospho-cam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000289", "map_id": "WBGene00000289", "name": "phospho-cam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A061AD72", "map_id": "A0A061AD72", "name": "phospho-kdin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006490", "map_id": "WBGene00006490", "name": "phospho-kdin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612373", "map_id": "none", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611311", "map_id": "none", "name": "p-MAPK3/MAPK1/MAPK7 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EBT1", "map_id": "G5EBT1", "name": "sma-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611329", "map_id": "none", "name": "MAPK3/MAPK1/MAPK7 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612370", "map_id": "none", "name": "ERK-specific DUSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "V6CIV8", "map_id": "V6CIV8", "name": "lip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003043", "map_id": "WBGene00003043", "name": "lip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUJ0", "map_id": "Q9XUJ0", "name": "DUSP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012372", "map_id": "WBGene00012372", "name": "DUSP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607466", "map_id": "none", "name": "ARMS is phosphorylated by active TrkA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607463", "map_id": "none", "name": "Active TrkA receptor:ARMS:Crk complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607846", "map_id": "none", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607837", "map_id": "none", "name": "p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P22981", "map_id": "P22981", "name": "let-60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002335", "map_id": "WBGene00002335", "name": "let-60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607842", "map_id": "Q19852", "name": "rgl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017891", "map_id": "WBGene00017891", "name": "rgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607844", "map_id": "none", "name": "Ras-GTP:RalGDS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19852", "map_id": "Q19852", "name": "rgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647187", "map_id": "none", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10607820", "map_id": "none", "name": "p-FRS2:CRKL binds C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10607811", "map_id": "none", "name": "Active TrkA receptor:p-FRS2:CRKL complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "E6N0V1", "map_id": "E6N0V1", "name": "phospho-rog-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018819", "map_id": "WBGene00018819", "name": "phospho-rog-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607818", "map_id": "none", "name": "Active TrkA receptor:p-FRS2:CRKL:RAPGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10664799", "map_id": "none", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10609591", "map_id": "none", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609556", "map_id": "none", "name": "MAPKAP kinase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10609574", "map_id": "none", "name": "p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10609588", "map_id": "none", "name": "Phospho-MAP kinase p38 (Mg2+ cofactor)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10611336", "map_id": "none", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611333", "map_id": "none", "name": "PP2A-ABdeltaC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A9UJN4", "map_id": "A9UJN4", "name": "pptr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007554", "map_id": "WBGene00007554", "name": "pptr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607445", "map_id": "none", "name": "Crk's SH3 domain engages C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10611042", "map_id": "none", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10664875", "map_id": "none", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640193", "map_id": "G5EBZ4", "name": "let-418", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00002637", "map_id": "WBGene00002637", "name": "let-418", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664859", "map_id": "Q22002", "name": "mab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003107", "map_id": "WBGene00003107", "name": "mab-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664871", "map_id": "none", "name": "RRAD gene:EGR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "U4PLQ8", "map_id": "U4PLQ8", "name": "egrh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044651", "map_id": "WBGene00044651", "name": "egrh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18250", "map_id": "Q18250", "name": "egrh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007772", "map_id": "WBGene00007772", "name": "egrh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBA8", "map_id": "U4PBA8", "name": "egrh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043705", "map_id": "WBGene00043705", "name": "egrh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664873", "map_id": "none", "name": "RRAD gene:EGR2:NAB2:CHD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EBZ4", "map_id": "G5EBZ4", "name": "let-418", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22002", "map_id": "Q22002", "name": "mab-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637627", "map_id": "none", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10635080", "map_id": "P50605", "name": "sdn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004749", "map_id": "WBGene00004749", "name": "phospho-sdn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614487", "map_id": "none", "name": "Fibronectin matrix", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9XXE9", "map_id": "Q9XXE9", "name": "phospho-p-FN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016769", "map_id": "WBGene00016769", "name": "phospho-p-FN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18705", "map_id": "Q18705", "name": "phospho-p-FN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637625", "map_id": "none", "name": "Syndecan-1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P50605", "map_id": "P50605", "name": "phospho-sdn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637623", "map_id": "none", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637619", "map_id": "none", "name": "Integrin alpha2beta1, (alpha6beta4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03600", "map_id": "Q03600", "name": "ina-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002081", "map_id": "WBGene00002081", "name": "ina-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27874", "map_id": "Q27874", "name": "pat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003930", "map_id": "WBGene00003930", "name": "pat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34446", "map_id": "P34446", "name": "pat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003929", "map_id": "WBGene00003929", "name": "pat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637621", "map_id": "none", "name": "Syndecan-1:Integrin alpha2beta1 (alpha6beta4)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637924", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637920", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10618504", "map_id": "none", "name": "Protein Kinase C, alpha type: DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90980", "map_id": "P90980", "name": "pkc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004033", "map_id": "WBGene00004033", "name": "pkc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10637922", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637535", "map_id": "none", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609836", "map_id": "Q11184", "name": "let-756", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00002881", "map_id": "WBGene00002881", "name": "let-756", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637533", "map_id": "none", "name": "SDC1,2,4,(3):FGF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q11184", "map_id": "Q11184", "name": "let-756", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638478", "map_id": "none", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638466", "map_id": "Q20644", "name": "DHX36", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009922", "map_id": "WBGene00009922", "name": "DHX36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3134861", "map_id": "none", "name": "Unmethylated CpG DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638468", "map_id": "none", "name": "DHX36:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20644", "map_id": "Q20644", "name": "DHX36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638476", "map_id": "none", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638470", "map_id": "Q22307", "name": "rha-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004355", "map_id": "WBGene00004355", "name": "rha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638472", "map_id": "none", "name": "DHX9:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22307", "map_id": "Q22307", "name": "rha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622778", "map_id": "none", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10622774", "map_id": "none", "name": "Kainate Receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P36609", "map_id": "P36609", "name": "ncs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003564", "map_id": "WBGene00003564", "name": "ncs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94288", "map_id": "Q94288", "name": "cal-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000287", "map_id": "WBGene00000287", "name": "cal-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1T5HUM0", "map_id": "A0A1T5HUM0", "name": "glr-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001618", "map_id": "WBGene00001618", "name": "glr-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18136", "map_id": "Q18136", "name": "cal-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006861", "map_id": "WBGene00006861", "name": "cal-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02217", "map_id": "O02217", "name": "rsa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007710", "map_id": "WBGene00007710", "name": "rsa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01623", "map_id": "O01623", "name": "glr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001616", "map_id": "WBGene00001616", "name": "glr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17697", "map_id": "Q17697", "name": "glr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001615", "map_id": "WBGene00001615", "name": "glr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04630", "map_id": "P04630", "name": "cal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000285", "map_id": "WBGene00000285", "name": "cal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34299", "map_id": "P34299", "name": "glr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001612", "map_id": "WBGene00001612", "name": "glr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09980", "map_id": "Q09980", "name": "cal-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017394", "map_id": "WBGene00017394", "name": "cal-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXV8", "map_id": "Q8MXV8", "name": "glr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001617", "map_id": "WBGene00001617", "name": "glr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09665", "map_id": "Q09665", "name": "tnc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006583", "map_id": "WBGene00006583", "name": "tnc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF37", "map_id": "G5EF37", "name": "pat-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003934", "map_id": "WBGene00003934", "name": "pat-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEG0", "map_id": "G5EEG0", "name": "cal-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000286", "map_id": "WBGene00000286", "name": "cal-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21415", "map_id": "Q21415", "name": "glr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001614", "map_id": "WBGene00001614", "name": "glr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02159", "map_id": "O02159", "name": "CALM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020378", "map_id": "WBGene00020378", "name": "CALM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10914", "map_id": "Q10914", "name": "glr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001613", "map_id": "WBGene00001613", "name": "glr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "O16305", "map_id": "O16305", "name": "cmd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000552", "map_id": "WBGene00000552", "name": "cmd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDZ8", "map_id": "G5EDZ8", "name": "cal-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000288", "map_id": "WBGene00000288", "name": "cal-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECY0", "map_id": "G5ECY0", "name": "dlg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001006", "map_id": "WBGene00001006", "name": "dlg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622776", "map_id": "none", "name": "Kainate receptor-glutamate complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10622781", "map_id": "none", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_74112", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_74016", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598836", "map_id": "none", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113567", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598833", "map_id": "Q10050", "name": "SLC25A15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00020422", "map_id": "WBGene00020422", "name": "SLC25A15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598710", "map_id": "none", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29896", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29676", "map_id": "CHEBI:58228", "name": "CAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113548", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598707", "map_id": "Q18990", "name": "pyr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00004259", "map_id": "WBGene00004259", "name": "pyr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30471", "map_id": "CHEBI:17533", "name": "NAcGlu", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10622848", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_374064", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_374061", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10622845", "map_id": "none", "name": "ARG2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A1X7RC97", "map_id": "A0A1X7RC97", "name": "argn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020658", "map_id": "WBGene00020658", "name": "argn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_266099", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10598720", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29514", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598717", "map_id": "none", "name": "ARG1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607315", "map_id": "none", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607308", "map_id": "G5ECU7", "name": "jun-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012005", "map_id": "WBGene00012005", "name": "phospho-jun-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607312", "map_id": "G5ECU7", "name": "phospho-jun-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10607290", "map_id": "none", "name": "p-MAPK8,9,10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2KZI0", "map_id": "H2KZI0", "name": "kgb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002188", "map_id": "WBGene00002188", "name": "kgb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44408", "map_id": "O44408", "name": "kgb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002187", "map_id": "WBGene00002187", "name": "kgb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQG9", "map_id": "Q8WQG9", "name": "jnk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002178", "map_id": "WBGene00002178", "name": "jnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607375", "map_id": "none", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607230", "map_id": "Q86MD3", "name": "phospho-atf-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000223", "map_id": "WBGene00000223", "name": "atf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607373", "map_id": "none", "name": "p-2S-cJUN:p-2T-ATF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86MD3", "map_id": "Q86MD3", "name": "atf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECU7", "map_id": "G5ECU7", "name": "phospho-jun-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622474", "map_id": "none", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622458", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDF7", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004758", "map_id": "WBGene00004758", "name": "phospho-sek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q58AU8", "map_id": "Q58AU8", "name": "phospho-sek-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018035", "map_id": "WBGene00018035", "name": "phospho-sek-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MPS3", "map_id": "Q8MPS3", "name": "phospho-sek-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022613", "map_id": "WBGene00022613", "name": "phospho-sek-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q58AU7", "map_id": "Q58AU7", "name": "phospho-sek-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018034", "map_id": "WBGene00018034", "name": "phospho-sek-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622472", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607371", "map_id": "none", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607329", "map_id": "none", "name": "MAPK8,9,10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607343", "map_id": "none", "name": "p-MAPK8,9,10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607368", "map_id": "none", "name": "p-MAP2K4/p-MAP2K7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01706", "map_id": "O01706", "name": "phospho-sek-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012162", "map_id": "WBGene00012162", "name": "phospho-sek-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21307", "map_id": "Q21307", "name": "phospho-mek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003185", "map_id": "WBGene00003185", "name": "phospho-mek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20347", "map_id": "Q20347", "name": "phospho-mkk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003368", "map_id": "WBGene00003368", "name": "phospho-mkk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622491", "map_id": "none", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622488", "map_id": "none", "name": "p38 MAPK:MAPKAPK2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622403", "map_id": "none", "name": "p-p38 MAPK: MAPKAPK2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607303", "map_id": "none", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607226", "map_id": "Q86MD3", "name": "atf-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10607300", "map_id": "none", "name": "Activated MAPK kinases ERK1/2, JNK, p38", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622517", "map_id": "none", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10622418", "map_id": "none", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622415", "map_id": "none", "name": "p-p38 MAPK:p-MAPKAPK2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622422", "map_id": "none", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622420", "map_id": "none", "name": "p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628646", "map_id": "none", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628634", "map_id": "none", "name": "ISG15:UBCH8:ISG15 E3 ligase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44820", "map_id": "O44820", "name": "ISG15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018660", "map_id": "WBGene00018660", "name": "ISG15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21633", "map_id": "Q21633", "name": "ubc-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006713", "map_id": "WBGene00006713", "name": "ubc-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01965", "map_id": "O01965", "name": "ari-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016158", "map_id": "WBGene00016158", "name": "ari-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628641", "map_id": "U4PBJ9", "name": "fln-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022048", "map_id": "WBGene00022048", "name": "phospho-fln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627823", "map_id": "Q21633", "name": "ubc-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628632", "map_id": "O01965", "name": "ari-1.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111294", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76577", "map_id": "CHEBI:456215", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628643", "map_id": "none", "name": "ISGylated Filamin B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "U4PBJ9", "map_id": "U4PBJ9", "name": "phospho-fln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625395", "map_id": "none", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10625381", "map_id": "none", "name": "p-Y701-STAT1:KPNA1:KPNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BIB8", "map_id": "Q9BIB8", "name": "imb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002075", "map_id": "WBGene00002075", "name": "imb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20703", "map_id": "Q20703", "name": "KPNA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009956", "map_id": "WBGene00009956", "name": "KPNA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625389", "map_id": "none", "name": "p-Y701-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10625393", "map_id": "Q9BIB8", "name": "imb-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10625391", "map_id": "Q20703", "name": "KPNA1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10628669", "map_id": "none", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628665", "map_id": "none", "name": "Homologues of PPM1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEM6", "map_id": "G5EEM6", "name": "tap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006524", "map_id": "WBGene00006524", "name": "tap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19775", "map_id": "Q19775", "name": "ppm-1.A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006460", "map_id": "WBGene00006460", "name": "ppm-1.A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628667", "map_id": "none", "name": "ISGylated PP2CB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663507", "map_id": "none", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8983696", "map_id": "none", "name": "2'-5' oligoadenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663504", "map_id": "O18005", "name": "pde-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011268", "map_id": "WBGene00011268", "name": "pde-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633391", "map_id": "none", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628679", "map_id": "none", "name": "ISGylated host proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8WQC9", "map_id": "Q8WQC9", "name": "drp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001093", "map_id": "WBGene00001093", "name": "drp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22070", "map_id": "Q22070", "name": "plc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004038", "map_id": "WBGene00004038", "name": "plc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDI8", "map_id": "G5EDI8", "name": "drh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001090", "map_id": "WBGene00001090", "name": "drh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93413", "map_id": "Q93413", "name": "drh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008400", "map_id": "WBGene00008400", "name": "drh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19192", "map_id": "Q19192", "name": "pek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003970", "map_id": "WBGene00003970", "name": "pek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_141681", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628677", "map_id": "none", "name": "ISG15 targets", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10633388", "map_id": "none", "name": "USP18-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22240", "map_id": "Q22240", "name": "USP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011507", "map_id": "WBGene00011507", "name": "USP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633412", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633398", "map_id": "none", "name": "ISGylated 4EHP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22888", "map_id": "Q22888", "name": "ife-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002062", "map_id": "WBGene00002062", "name": "ife-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10633408", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20935", "map_id": "Q20935", "name": "EIF4A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018997", "map_id": "WBGene00018997", "name": "EIF4A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27639", "map_id": "P27639", "name": "inf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002083", "map_id": "WBGene00002083", "name": "inf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10633410", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10633406", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666093", "map_id": "none", "name": "p-STAT1dimer:KPNA1 binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666087", "map_id": "none", "name": "p-STAT1 dimer:KPNA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10614210", "map_id": "Q9BIB8", "name": "imb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10666091", "map_id": "none", "name": "p-STAT1 dimer:KPNA1:KPNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628681", "map_id": "none", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10666089", "map_id": "none", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614205", "map_id": "Q20703", "name": "KPNA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625312", "map_id": "none", "name": "p-Y701-STAT1-1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628650", "map_id": "none", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628625", "map_id": "O44820", "name": "ISG15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627458", "map_id": "A0A061ACQ8", "name": "NEDD4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022358", "map_id": "WBGene00022358", "name": "NEDD4L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628648", "map_id": "none", "name": "ISG15:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061ACQ8", "map_id": "A0A061ACQ8", "name": "NEDD4L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633414", "map_id": "none", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633396", "map_id": "Q22888", "name": "ife-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625031", "map_id": "none", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10625021", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625029", "map_id": "none", "name": "p-STAT1 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628639", "map_id": "none", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627828", "map_id": "Q27481", "name": "uba-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006699", "map_id": "WBGene00006699", "name": "uba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628636", "map_id": "none", "name": "ISG15:UBA7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27481", "map_id": "Q27481", "name": "uba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10628659", "map_id": "none", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628627", "map_id": "none", "name": "ISG15:UBCH8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628654", "map_id": "none", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612207", "map_id": "Q95XX0", "name": "ubc-13", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628652", "map_id": "none", "name": "ISGylated E2 conjugating enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628656", "map_id": "none", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10657691", "map_id": "none", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10657686", "map_id": "Q11184", "name": "let-756", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10609860", "map_id": "Q11184", "name": "let-756", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10646301", "map_id": "none", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636505", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDP9", "map_id": "G5EDP9", "name": "aap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000001", "map_id": "WBGene00000001", "name": "aap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646280", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608583", "map_id": "none", "name": "p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646277", "map_id": "none", "name": "Activated FGFR2:p-FRS:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N5D3", "map_id": "Q9N5D3", "name": "sos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004947", "map_id": "WBGene00004947", "name": "sos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646291", "map_id": "none", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608561", "map_id": "none", "name": "GRB2:GAB1:PIK3R1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10636509", "map_id": "none", "name": "Activated FGFR4:p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10636511", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646246", "map_id": "none", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10646242", "map_id": "G5EDX1", "name": "kal-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00002181", "map_id": "WBGene00002181", "name": "kal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_190915", "map_id": "CHEBI:28815", "name": "HS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10646244", "map_id": "none", "name": "KAL1:HS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EDX1", "map_id": "G5EDX1", "name": "kal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646181", "map_id": "none", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646176", "map_id": "none", "name": "activated FGFR4:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646178", "map_id": "none", "name": "activated FGFR4:p-4Y-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646260", "map_id": "none", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646248", "map_id": "none", "name": "Activated FGFR1:FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10636501", "map_id": "none", "name": "Activated FGFR1:p-FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646204", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646201", "map_id": "none", "name": "Activated FGFR3:p-FRS:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646197", "map_id": "none", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646194", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646267", "map_id": "none", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602407", "map_id": "none", "name": "GRB2-1:SOS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646192", "map_id": "none", "name": "Activated FGFR1:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646298", "map_id": "none", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646289", "map_id": "none", "name": "Activated FGFR4:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646293", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646265", "map_id": "none", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646262", "map_id": "none", "name": "Activated FGFR1:FRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646190", "map_id": "none", "name": "Activated FGFR1:p-FRS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657689", "map_id": "none", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10657684", "map_id": "Q11184", "name": "let-756", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205687", "map_id": "CHEBI:58223", "name": "UDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10625450", "map_id": "none", "name": "Homologues of GALNT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P34678", "map_id": "P34678", "name": "gly-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001628", "map_id": "WBGene00001628", "name": "gly-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61394", "map_id": "O61394", "name": "gly-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001631", "map_id": "WBGene00001631", "name": "gly-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608563", "map_id": "none", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602412", "map_id": "G5EDP9", "name": "aap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608459", "map_id": "none", "name": "GRB2:GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646269", "map_id": "none", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636503", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646253", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646250", "map_id": "none", "name": "Activated FGFR1:p-8T-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646174", "map_id": "none", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646169", "map_id": "none", "name": "activated FGFR1:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646171", "map_id": "none", "name": "activated FGFR1:p-4Y-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646255", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646208", "map_id": "none", "name": "Activated FGFR4:FRS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646221", "map_id": "none", "name": "Activated FGFR4:p-8T-FRS2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10655619", "map_id": "none", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10599987", "map_id": "Q18999", "name": "ptb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004207", "map_id": "WBGene00004207", "name": "ptb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655615", "map_id": "none", "name": "capped, methylated pre-FGFR2 mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3I0", "map_id": "Q9U3I0", "name": "rpb-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009078", "map_id": "WBGene00009078", "name": "rpb-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02092", "map_id": "O02092", "name": "rpb-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018391", "map_id": "WBGene00018391", "name": "rpb-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17684", "map_id": "Q17684", "name": "rpb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007355", "map_id": "WBGene00007355", "name": "rpb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10578", "map_id": "Q10578", "name": "rpb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016140", "map_id": "WBGene00016140", "name": "rpb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16356", "map_id": "P16356", "name": "phospho-ama-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000123", "map_id": "WBGene00000123", "name": "phospho-ama-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYM8", "map_id": "Q8MYM8", "name": "gtf-2f2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012694", "map_id": "WBGene00012694", "name": "gtf-2f2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5K2", "map_id": "Q9N5K2", "name": "rpb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019246", "map_id": "WBGene00019246", "name": "rpb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19826", "map_id": "Q19826", "name": "rpb-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017830", "map_id": "WBGene00017830", "name": "rpb-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93338", "map_id": "Q93338", "name": "rpb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007971", "map_id": "WBGene00007971", "name": "rpb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S0", "map_id": "Q965S0", "name": "rpb-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022400", "map_id": "WBGene00022400", "name": "rpb-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GR61", "map_id": "Q9GR61", "name": "rpb-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021347", "map_id": "WBGene00021347", "name": "rpb-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17558", "map_id": "Q17558", "name": "gtf-2f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015296", "map_id": "WBGene00015296", "name": "gtf-2f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3C9", "map_id": "Q9N3C9", "name": "rpb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021845", "map_id": "WBGene00021845", "name": "rpb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVH6", "map_id": "Q9XVH6", "name": "rpb-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012187", "map_id": "WBGene00012187", "name": "rpb-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600001", "map_id": "none", "name": "Homologues of HNRNPA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q4W5P0", "map_id": "Q4W5P0", "name": "sqd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022235", "map_id": "WBGene00022235", "name": "sqd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34541", "map_id": "P34541", "name": "HNRNPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019881", "map_id": "WBGene00019881", "name": "HNRNPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655617", "map_id": "none", "name": "FGFR2 IIIc-specific splicing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q18999", "map_id": "Q18999", "name": "ptb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646223", "map_id": "none", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10646287", "map_id": "none", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646282", "map_id": "none", "name": "Activated FGFR4:FRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646284", "map_id": "none", "name": "Activated FGFR4:p-FRS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646296", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10646237", "map_id": "none", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646233", "map_id": "none", "name": "FGFRL1-binding FGFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EEF1", "map_id": "G5EEF1", "name": "egl-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001185", "map_id": "WBGene00001185", "name": "egl-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646231", "map_id": "none", "name": "FGFRL1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95XJ7", "map_id": "Q95XJ7", "name": "igcm-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022418", "map_id": "WBGene00022418", "name": "igcm-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646235", "map_id": "none", "name": "FGFRL1-binding FGFs:FGFRL1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646304", "map_id": "none", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636513", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10638456", "map_id": "none", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638454", "map_id": "O44326", "name": "phospho-hmp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001979", "map_id": "WBGene00001979", "name": "hmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638452", "map_id": "O44326", "name": "phospho-hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10632792", "map_id": "none", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1614519", "map_id": "CHEBI:16345", "name": "3-Sulfinoalanine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10632789", "map_id": "none", "name": "CDO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20893", "map_id": "Q20893", "name": "cdo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018986", "map_id": "WBGene00018986", "name": "cdo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10632759", "map_id": "none", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614532", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614582", "map_id": "CHEBI:21347", "name": "L-Lanthionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10632750", "map_id": "none", "name": "PXLP-K212-CTH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P55216", "map_id": "P55216", "name": "cth-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022856", "map_id": "WBGene00022856", "name": "cth-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664432", "map_id": "none", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10664428", "map_id": "none", "name": "CysS248-MPST:TXN2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q17424", "map_id": "Q17424", "name": "trx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007099", "map_id": "WBGene00007099", "name": "trx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEV0", "map_id": "G5EEV0", "name": "mpst-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011307", "map_id": "WBGene00011307", "name": "mpst-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639552", "map_id": "Q17424", "name": "trx-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1655881", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10663602", "map_id": "G5EEV0", "name": "mpst-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10663852", "map_id": "none", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614595", "map_id": "CHEBI:16094", "name": "S2O3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013199", "map_id": "CHEBI:18407", "name": "HCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013207", "map_id": "CHEBI:17359", "name": "SO3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013191", "map_id": "CHEBI:29200", "name": "HSCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10632779", "map_id": "none", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632742", "map_id": "none", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1614584", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113544", "map_id": "CHEBI:30797", "name": "MAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10615389", "map_id": "G5EE96", "name": "slc-25a10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00019656", "map_id": "WBGene00019656", "name": "slc-25a10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664426", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012592", "map_id": "CHEBI:16208", "name": "3MPYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10664424", "map_id": "G5EEV0", "name": "mpst-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10632740", "map_id": "none", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614538", "map_id": "CHEBI:17359", "name": "sulfite(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10632737", "map_id": "none", "name": "holo-SUOX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q9XTQ8", "map_id": "Q9XTQ8", "name": "suox-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010397", "map_id": "WBGene00010397", "name": "suox-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663887", "map_id": "none", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013543", "map_id": "LigandDisplayForward?ligandId=9830", "name": "sulfanegen", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10664430", "map_id": "none", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10639549", "map_id": "Q17424", "name": "trx-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10632782", "map_id": "none", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936714", "map_id": "CHEBI:30831", "name": "2OBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632777", "map_id": "none", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10632765", "map_id": "O62133", "name": "sqrd-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008538", "map_id": "WBGene00008538", "name": "sqrd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10632767", "map_id": "O62133", "name": "sqrd-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10632774", "map_id": "none", "name": "ETHE1:2Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17636", "map_id": "O17636", "name": "ethe-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007886", "map_id": "WBGene00007886", "name": "ethe-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632753", "map_id": "none", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614594", "map_id": "CHEBI:62856", "name": "HLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10663605", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012724", "map_id": "CHEBI:17137", "name": "HSO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10656962", "map_id": "none", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6814151", "map_id": "CHEBI:17141", "name": "2AET", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656959", "map_id": "none", "name": "ADO:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IAA1", "map_id": "Q8IAA1", "name": "ADO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021750", "map_id": "WBGene00021750", "name": "ADO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663885", "map_id": "none", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10657228", "map_id": "none", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4085415", "map_id": "CHEBI:16518", "name": "Fe(2+)Cb5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690558", "map_id": "CHEBI:15534", "name": "OLE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4085425", "map_id": "CHEBI:18097", "name": "Fe(3+)Cb5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657225", "map_id": "none", "name": "SCD5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EGN2", "map_id": "G5EGN2", "name": "fat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001398", "map_id": "WBGene00001398", "name": "fat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED44", "map_id": "G5ED44", "name": "fat-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001397", "map_id": "WBGene00001397", "name": "fat-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGH6", "map_id": "G5EGH6", "name": "fat-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001399", "map_id": "WBGene00001399", "name": "fat-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623933", "map_id": "none", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548809", "map_id": "CHEBI:50570", "name": "TOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623928", "map_id": "Q9N5Y2", "name": "art-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00000198", "map_id": "WBGene00000198", "name": "art-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648592", "map_id": "none", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_5690533", "map_id": "none", "name": "PALM:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_6785219", "map_id": "CHEBI:36080", "name": "protein", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_390435", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5690516", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10648589", "map_id": "Q20390", "name": "ppt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00004092", "map_id": "WBGene00004092", "name": "ppt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623940", "map_id": "none", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76194", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623937", "map_id": "none", "name": "ACSL3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20121", "map_id": "Q20121", "name": "acs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018152", "map_id": "WBGene00018152", "name": "acs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0ING4", "map_id": "A0A4V0ING4", "name": "acs-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016716", "map_id": "WBGene00016716", "name": "acs-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602893", "map_id": "none", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76183", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602885", "map_id": "none", "name": "ACLY tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P53585", "map_id": "P53585", "name": "acly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016995", "map_id": "WBGene00016995", "name": "acly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602891", "map_id": "Q23243", "name": "morc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022531", "map_id": "WBGene00022531", "name": "morc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611701", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611698", "map_id": "none", "name": "ACSL1,3,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O44560", "map_id": "O44560", "name": "acs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020343", "map_id": "WBGene00020343", "name": "acs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLI5", "map_id": "V6CLI5", "name": "acs-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022037", "map_id": "WBGene00022037", "name": "acs-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16775", "map_id": "O16775", "name": "acs-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019920", "map_id": "WBGene00019920", "name": "acs-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21872", "map_id": "Q21872", "name": "acs-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011173", "map_id": "WBGene00011173", "name": "acs-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602965", "map_id": "none", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602962", "map_id": "none", "name": "FASN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91871", "map_id": "P91871", "name": "phospho-fasn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009342", "map_id": "WBGene00009342", "name": "phospho-fasn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647332", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647329", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O17040", "map_id": "O17040", "name": "hpo-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020517", "map_id": "WBGene00020517", "name": "hpo-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21905", "map_id": "Q21905", "name": "PTPLAD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011205", "map_id": "WBGene00011205", "name": "PTPLAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623876", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623873", "map_id": "P49191", "name": "elo-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00001241", "map_id": "WBGene00001241", "name": "elo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623920", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623917", "map_id": "none", "name": "ELOVL3,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NAC6", "map_id": "Q9NAC6", "name": "elo-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001247", "map_id": "WBGene00001247", "name": "elo-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20904", "map_id": "Q20904", "name": "elo-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001245", "map_id": "WBGene00001245", "name": "elo-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20300", "map_id": "Q20300", "name": "elo-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001243", "map_id": "WBGene00001243", "name": "elo-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03574", "map_id": "Q03574", "name": "elo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001242", "map_id": "WBGene00001242", "name": "elo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE5", "map_id": "G5EEE5", "name": "elo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001239", "map_id": "WBGene00001239", "name": "elo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ9", "map_id": "Q9XVQ9", "name": "elo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001240", "map_id": "WBGene00001240", "name": "elo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20303", "map_id": "Q20303", "name": "elo-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001244", "map_id": "WBGene00001244", "name": "elo-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49191", "map_id": "P49191", "name": "elo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611571", "map_id": "none", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602921", "map_id": "none", "name": "Homologues of Btn-ACACA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUC3", "map_id": "Q9XUC3", "name": "Btn-ACACA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012131", "map_id": "WBGene00012131", "name": "Btn-ACACA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0M0", "map_id": "H2L0M0", "name": "phospho-pod-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004076", "map_id": "WBGene00004076", "name": "phospho-pod-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623923", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610418", "map_id": "Q10130", "name": "dhs-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00000969", "map_id": "WBGene00000969", "name": "dhs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606634", "map_id": "none", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602960", "map_id": "P91871", "name": "phospho-fasn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648602", "map_id": "none", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10648599", "map_id": "none", "name": "SCD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10602902", "map_id": "none", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10602899", "map_id": "P34519", "name": "SLC25A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00010780", "map_id": "WBGene00010780", "name": "SLC25A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664094", "map_id": "none", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29450", "map_id": "CHEBI:57925", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023653", "map_id": "CHEBI:138565", "name": "18(R)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111745", "map_id": "CHEBI:58297", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664087", "map_id": "A8WFK6", "name": "gpx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019846", "map_id": "WBGene00019846", "name": "gpx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664092", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023712", "map_id": "CHEBI:81559", "name": "18(R)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614862", "map_id": "none", "name": "LTA4H:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFT4", "map_id": "G5EFT4", "name": "ltah-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016589", "map_id": "WBGene00016589", "name": "ltah-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662619", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10662607", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q19189", "map_id": "Q19189", "name": "prx-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004197", "map_id": "WBGene00004197", "name": "prx-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18355", "map_id": "Q18355", "name": "PEX10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016318", "map_id": "WBGene00016318", "name": "PEX10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20617", "map_id": "Q20617", "name": "ubc-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006719", "map_id": "WBGene00006719", "name": "ubc-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93930", "map_id": "Q93930", "name": "prx-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004199", "map_id": "WBGene00004199", "name": "prx-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19951", "map_id": "Q19951", "name": "prx-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004198", "map_id": "WBGene00004198", "name": "prx-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1U4", "map_id": "Q9U1U4", "name": "ubc-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006714", "map_id": "WBGene00006714", "name": "ubc-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35129", "map_id": "P35129", "name": "let-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002344", "map_id": "WBGene00002344", "name": "let-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662616", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10628859", "map_id": "none", "name": "UBE2D1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660992", "map_id": "none", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660981", "map_id": "none", "name": "RNF152:RRAGA:GDP:Ub:UBE2N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q19214", "map_id": "Q19214", "name": "TRIM32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008588", "map_id": "WBGene00008588", "name": "TRIM32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22743", "map_id": "Q22743", "name": "raga-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006414", "map_id": "WBGene00006414", "name": "raga-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660979", "map_id": "none", "name": "Ub:UBE2N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660989", "map_id": "none", "name": "K63polyUb-K142,K220,K230,K244-RRAGA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660972", "map_id": "Q19214", "name": "RNF152", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10660994", "map_id": "none", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660974", "map_id": "none", "name": "RRAGA:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662609", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10662605", "map_id": "none", "name": "Ub:UBE2D1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10662601", "map_id": "none", "name": "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10643471", "map_id": "none", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10643464", "map_id": "none", "name": "C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EFG0", "map_id": "G5EFG0", "name": "sel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004759", "map_id": "WBGene00004759", "name": "sel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21997", "map_id": "Q21997", "name": "DERL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020109", "map_id": "WBGene00020109", "name": "DERL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20798", "map_id": "Q20798", "name": "sel-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004768", "map_id": "WBGene00004768", "name": "sel-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54812", "map_id": "P54812", "name": "cdc-48.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008053", "map_id": "WBGene00008053", "name": "cdc-48.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09396", "map_id": "Q09396", "name": "OS9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018611", "map_id": "WBGene00018611", "name": "OS9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NF22", "map_id": "Q9NF22", "name": "ERLEC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013667", "map_id": "WBGene00013667", "name": "ERLEC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643468", "map_id": "none", "name": "ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10645821", "map_id": "none", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10645817", "map_id": "H2L0G5", "name": "ptc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "WBGene00004210", "map_id": "WBGene00004210", "name": "ptc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645819", "map_id": "H2L0G5", "name": "ptc-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "false" }, { "id": "reaction_10644533", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10644526", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19523", "map_id": "Q19523", "name": "acy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000068", "map_id": "WBGene00000068", "name": "acy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16880", "map_id": "O16880", "name": "acy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000069", "map_id": "WBGene00000069", "name": "acy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966F9", "map_id": "Q966F9", "name": "acy-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000071", "map_id": "WBGene00000071", "name": "acy-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644531", "map_id": "none", "name": "GPR161:IFT-A:TULP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q09306", "map_id": "Q09306", "name": "tub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006655", "map_id": "WBGene00006655", "name": "tub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECZ4", "map_id": "G5ECZ4", "name": "dyf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001118", "map_id": "WBGene00001118", "name": "dyf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18859", "map_id": "Q18859", "name": "ifta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016935", "map_id": "WBGene00016935", "name": "ifta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFW7", "map_id": "G5EFW7", "name": "daf-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000906", "map_id": "WBGene00000906", "name": "daf-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20255", "map_id": "Q20255", "name": "ift-139", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022696", "map_id": "WBGene00022696", "name": "ift-139", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90757", "map_id": "P90757", "name": "che-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000490", "map_id": "WBGene00000490", "name": "che-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645932", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645929", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34568", "map_id": "P34568", "name": "bath-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011815", "map_id": "WBGene00011815", "name": "bath-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYJ3", "map_id": "H2KYJ3", "name": "bath-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015567", "map_id": "WBGene00015567", "name": "bath-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34371", "map_id": "P34371", "name": "bath-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016803", "map_id": "WBGene00016803", "name": "bath-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94420", "map_id": "Q94420", "name": "mel-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003209", "map_id": "WBGene00003209", "name": "mel-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41886", "map_id": "P41886", "name": "bath-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018137", "map_id": "WBGene00018137", "name": "bath-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17391", "map_id": "Q17391", "name": "cul-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000838", "map_id": "WBGene00000838", "name": "cul-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NF14", "map_id": "Q9NF14", "name": "bath-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013689", "map_id": "WBGene00013689", "name": "bath-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23457", "map_id": "Q23457", "name": "rbx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004320", "map_id": "WBGene00004320", "name": "rbx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597874", "map_id": "P0CG71", "name": "ubq-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10645923", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10644620", "map_id": "none", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627451", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007009", "map_id": "WBGene00007009", "name": "wwp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621559", "map_id": "Q9XTY6", "name": "num-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003830", "map_id": "WBGene00003830", "name": "num-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644618", "map_id": "none", "name": "NUMB:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N2Z7", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTY6", "map_id": "Q9XTY6", "name": "num-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644632", "map_id": "none", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10644628", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "P30625", "map_id": "P30625", "name": "kin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002190", "map_id": "WBGene00002190", "name": "kin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21137", "map_id": "P21137", "name": "kin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002189", "map_id": "WBGene00002189", "name": "kin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644622", "map_id": "P21137", "name": "kin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "false" }, { "id": "species_10644630", "map_id": "none", "name": "PKA regulatory subunits:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10644522", "map_id": "none", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10644487", "map_id": "Q09306", "name": "tub-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "species_10644518", "map_id": "none", "name": "IFT-A complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10644520", "map_id": "none", "name": "IFT-A complex:TULP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10645925", "map_id": "none", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645921", "map_id": "none", "name": "SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10609534", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608347", "map_id": "none", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158471", "map_id": "CHEBI:58339", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176564", "map_id": "CHEBI:35432", "name": "3,5,3'-triiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158466", "map_id": "CHEBI:58343", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608337", "map_id": "none", "name": "SULT dimers (T2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2Z2", "map_id": "Q9U2Z2", "name": "ssu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013748", "map_id": "WBGene00013748", "name": "ssu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629186", "map_id": "none", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629183", "map_id": "none", "name": "GGCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18596", "map_id": "Q18596", "name": "GGCT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016629", "map_id": "WBGene00016629", "name": "GGCT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608127", "map_id": "none", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608120", "map_id": "none", "name": "MTRR:MTR(MeCbl)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17574", "map_id": "Q17574", "name": "mtrr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006510", "map_id": "WBGene00006510", "name": "mtrr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28115", "map_id": "CHEBI:28115", "name": "CHEBI:28115", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q09582", "map_id": "Q09582", "name": "metr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010988", "map_id": "WBGene00010988", "name": "metr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10608124", "map_id": "none", "name": "MTRR:MTR(cob(I)alamin)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3159260", "map_id": "CHEBI:15982", "name": "cob(I)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608162", "map_id": "none", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71285", "map_id": "CHEBI:57856", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83909", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10608159", "map_id": "none", "name": "AHCY:NAD+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P27604", "map_id": "P27604", "name": "ahcy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019322", "map_id": "WBGene00019322", "name": "ahcy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10662568", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8953493", "map_id": "CHEBI:456215", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10662565", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q5ZEQ3", "map_id": "Q5ZEQ3", "name": "gpap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012390", "map_id": "WBGene00012390", "name": "gpap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10606293", "map_id": "none", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158858", "map_id": "CHEBI:15882", "name": "PhOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158850", "map_id": "CHEBI:27905", "name": "Phenyl sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605955", "map_id": "none", "name": "SULT1A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608369", "map_id": "none", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176575", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176501", "map_id": "CHEBI:17474", "name": "E1S", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10608331", "map_id": "none", "name": "SULT1E1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608104", "map_id": "none", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_158601", "map_id": "CHEBI:58052", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_162756", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3499326", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_174384", "map_id": "CHEBI:58052", "name": "UDP-GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10608101", "map_id": "none", "name": "SLC35D1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q18779", "map_id": "Q18779", "name": "sqv-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005025", "map_id": "WBGene00005025", "name": "sqv-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608191", "map_id": "none", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71284", "map_id": "CHEBI:59789", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_175973", "map_id": "CHEBI:16227", "name": "PY", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_175979", "map_id": "CHEBI:15761", "name": "MP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608188", "map_id": "P34254", "name": "anmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015124", "map_id": "WBGene00015124", "name": "anmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661289", "map_id": "none", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1247892", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1247934", "map_id": "CHEBI:4047", "name": "CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10598417", "map_id": "none", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29494", "map_id": "CHEBI:46398", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598414", "map_id": "none", "name": "8xUGP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUS5", "map_id": "Q9XUS5", "name": "rml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010665", "map_id": "WBGene00010665", "name": "rml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606403", "map_id": "none", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159557", "map_id": "CHEBI:32587", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29374", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159572", "map_id": "CHEBI:9008", "name": "SUA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10606398", "map_id": "none", "name": "GLYAT-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95ZT6", "map_id": "Q95ZT6", "name": "GLYAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018400", "map_id": "WBGene00018400", "name": "GLYAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22371", "map_id": "Q22371", "name": "GLYAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608094", "map_id": "none", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608091", "map_id": "none", "name": "GCL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A9CZN9", "map_id": "A9CZN9", "name": "GCLM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017084", "map_id": "WBGene00017084", "name": "GCLM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20117", "map_id": "Q20117", "name": "gcs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001527", "map_id": "WBGene00001527", "name": "gcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608137", "map_id": "none", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174370", "map_id": "CHEBI:17709", "name": "APS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608132", "map_id": "A0A061AE05", "name": "pps-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004091", "map_id": "WBGene00004091", "name": "pps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608340", "map_id": "none", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176486", "map_id": "CHEBI:35430", "name": "3,3'-diiodothyronine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176519", "map_id": "CHEBI:35431", "name": "3,3'-diiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608374", "map_id": "none", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176566", "map_id": "CHEBI:17931", "name": "N-hydroxy-2-acetylaminofluorene", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176500", "map_id": "CHEBI:35424", "name": "AAF-N-S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608371", "map_id": "none", "name": "SULTs active on NH2AAF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606330", "map_id": "none", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_159352", "map_id": "CHEBI:37946", "name": "DAOS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624752", "map_id": "none", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10624749", "map_id": "none", "name": "SLC35B2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8MXJ9", "map_id": "Q8MXJ9", "name": "pst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004206", "map_id": "WBGene00004206", "name": "pst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20787", "map_id": "Q20787", "name": "pst-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018827", "map_id": "WBGene00018827", "name": "pst-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619928", "map_id": "none", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10619925", "map_id": "none", "name": "SLC26A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFB2", "map_id": "G5EFB2", "name": "sulp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013963", "map_id": "WBGene00013963", "name": "sulp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94225", "map_id": "Q94225", "name": "sulp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018283", "map_id": "WBGene00018283", "name": "sulp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDS5", "map_id": "G5EDS5", "name": "sulp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017464", "map_id": "WBGene00017464", "name": "sulp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17951", "map_id": "O17951", "name": "sulp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010789", "map_id": "WBGene00010789", "name": "sulp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC30", "map_id": "G5EC30", "name": "sulp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012259", "map_id": "WBGene00012259", "name": "sulp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45016", "map_id": "O45016", "name": "sulp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020914", "map_id": "WBGene00020914", "name": "sulp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EED0", "map_id": "G5EED0", "name": "sulp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016945", "map_id": "WBGene00016945", "name": "sulp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEA7", "map_id": "G5EEA7", "name": "sulp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010788", "map_id": "WBGene00010788", "name": "sulp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10654763", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806829", "map_id": "CHEBI:17826", "name": "MMAIII", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6800127", "map_id": "CHEBI:48765", "name": "DMAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10654757", "map_id": "none", "name": "N6AMT1:TRMT112", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16582", "map_id": "O16582", "name": "mtq-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016341", "map_id": "WBGene00016341", "name": "mtq-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45241", "map_id": "O45241", "name": "TRMT112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007312", "map_id": "WBGene00007312", "name": "TRMT112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608355", "map_id": "none", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608352", "map_id": "Q23493", "name": "bpnt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00044063", "map_id": "WBGene00044063", "name": "bpnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629176", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247904", "map_id": "CHEBI:4047", "name": "CysGly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629173", "map_id": "none", "name": "CNDP2:2Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18000", "map_id": "O18000", "name": "pes-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003982", "map_id": "WBGene00003982", "name": "pes-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608366", "map_id": "none", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695950", "map_id": "CHEBI:16836", "name": "PNP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176600", "map_id": "CHEBI:35422", "name": "p-nitrophenol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608363", "map_id": "none", "name": "SULT1A1,A2,C2,4A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606401", "map_id": "none", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159447", "map_id": "CHEBI:15515", "name": "BEZ-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159564", "map_id": "CHEBI:18089", "name": "HIPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10639385", "map_id": "none", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3301954", "map_id": "CHEBI:34718", "name": "CDNB", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1655887", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301973", "map_id": "CHEBI:17883", "name": "HCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301969", "map_id": "CHEBI:8927", "name": "DNPSG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10639382", "map_id": "none", "name": "GSTK1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18973", "map_id": "Q18973", "name": "gstk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017054", "map_id": "WBGene00017054", "name": "gstk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608140", "map_id": "none", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10629196", "map_id": "none", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629193", "map_id": "none", "name": "OPLAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A9S2", "map_id": "A0A9S2", "name": "OPLAH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021430", "map_id": "WBGene00021430", "name": "OPLAH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649482", "map_id": "none", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696214", "map_id": "CHEBI:16005", "name": "methylarsonate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696224", "map_id": "CHEBI:14597", "name": "methylarsonite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608209", "map_id": "none", "name": "GSTO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34345", "map_id": "P34345", "name": "gsto-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016204", "map_id": "WBGene00016204", "name": "gsto-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608345", "map_id": "none", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176619", "map_id": "CHEBI:16469", "name": "E2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176492", "map_id": "CHEBI:4866", "name": "E2-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607919", "map_id": "none", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607916", "map_id": "none", "name": "6xUGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19905", "map_id": "Q19905", "name": "sqv-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005022", "map_id": "WBGene00005022", "name": "sqv-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608150", "map_id": "none", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608147", "map_id": "none", "name": "GSS:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21549", "map_id": "Q21549", "name": "gss-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010941", "map_id": "WBGene00010941", "name": "gss-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605958", "map_id": "none", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158469", "map_id": "CHEBI:46195", "name": "PARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158472", "map_id": "CHEBI:32635", "name": "PARA-SO4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10606295", "map_id": "none", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158847", "map_id": "CHEBI:16580", "name": "NHABP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158859", "map_id": "CHEBI:32701", "name": "NHABP-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608357", "map_id": "none", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176496", "map_id": "CHEBI:16814", "name": "DHEA-SO4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10608343", "map_id": "none", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176665", "map_id": "CHEBI:35420", "name": "PREGS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608256", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_76396", "map_id": "CHEBI:29132", "name": "NABQI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9753685", "map_id": "CHEBI:32639", "name": "APAP-SG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608253", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45352", "map_id": "O45352", "name": "gst-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001792", "map_id": "WBGene00001792", "name": "gst-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45010", "map_id": "O45010", "name": "GSTA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021127", "map_id": "WBGene00021127", "name": "GSTA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09596", "map_id": "Q09596", "name": "gst-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001753", "map_id": "WBGene00001753", "name": "gst-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17234", "map_id": "O17234", "name": "gsto-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019636", "map_id": "WBGene00019636", "name": "gsto-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D7SFI3", "map_id": "D7SFI3", "name": "GSTO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043097", "map_id": "WBGene00043097", "name": "GSTO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34277", "map_id": "P34277", "name": "gsto-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015337", "map_id": "WBGene00015337", "name": "gsto-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18938", "map_id": "Q18938", "name": "gst-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001790", "map_id": "WBGene00001790", "name": "gst-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10299", "map_id": "P10299", "name": "gst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001749", "map_id": "WBGene00001749", "name": "gst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648957", "map_id": "none", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113519", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693723", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194712", "map_id": "CHEBI:30751", "name": "formate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10648954", "map_id": "none", "name": "ESD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "G5EF86", "map_id": "G5EF86", "name": "ESD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013018", "map_id": "WBGene00013018", "name": "ESD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606424", "map_id": "none", "name": "Furin cleaves pro-prothrombin to prothrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10606405", "map_id": "Q93518", "name": "10xCbxE-F2(25-622)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "WBGene00008879", "map_id": "WBGene00008879", "name": "thrombin heavy chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606409", "map_id": "Q93518", "name": "prothrombin (factor II) propeptide", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10606407", "map_id": "Q93518", "name": "10xCbxE-F2(44-622)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10606421", "map_id": "none", "name": "Homologues of FURIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O17798", "map_id": "O17798", "name": "kpc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002232", "map_id": "WBGene00002232", "name": "kpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P51559", "map_id": "P51559", "name": "bli-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000254", "map_id": "WBGene00000254", "name": "bli-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650363", "map_id": "none", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6788753", "map_id": "CHEBI:86019", "name": "S-FARN-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788758", "map_id": "CHEBI:87167", "name": "S-FARN-CME", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10650360", "map_id": "none", "name": "ICMT:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P91402", "map_id": "P91402", "name": "ICMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019710", "map_id": "WBGene00019710", "name": "ICMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643368", "map_id": "none", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643348", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001167", "map_id": "WBGene00001167", "name": "eef-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_353106", "map_id": "CHEBI:17509", "name": "MTAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643335", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643365", "map_id": "none", "name": "DPH1:DPH2:DPH3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09454", "map_id": "Q09454", "name": "dph-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007488", "map_id": "WBGene00007488", "name": "dph-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49958", "map_id": "P49958", "name": "dph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007576", "map_id": "WBGene00007576", "name": "dph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21102", "map_id": "Q21102", "name": "DPH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010484", "map_id": "WBGene00010484", "name": "DPH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606692", "map_id": "none", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10606676", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(31-691)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q9XWD6", "map_id": "Q9XWD6", "name": "phospho-ced-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000415", "map_id": "WBGene00000415", "name": "phospho-ced-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23046", "map_id": "Q23046", "name": "phospho-p-GAS6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020806", "map_id": "WBGene00020806", "name": "phospho-p-GAS6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606684", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(39-691)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10606690", "map_id": "none", "name": "Homologues of GAS6(31-38)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10643346", "map_id": "none", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643338", "map_id": "P29691", "name": "eef-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643343", "map_id": "Q17514", "name": "DPH5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007194", "map_id": "WBGene00007194", "name": "DPH5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650384", "map_id": "none", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788865", "map_id": "none", "name": "PsiAm, RibAm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:87176", "map_id": "CHEBI:87176", "name": "CHEBI:87176", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:87177", "map_id": "CHEBI:87177", "name": "CHEBI:87177", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788858", "map_id": "none", "name": "PsiAm3P, RibAm3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:87180", "map_id": "CHEBI:87180", "name": "CHEBI:87180", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:87179", "map_id": "CHEBI:87179", "name": "CHEBI:87179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650381", "map_id": "Q9U2U7", "name": "FN3KRP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013802", "map_id": "WBGene00013802", "name": "FN3KRP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606430", "map_id": "none", "name": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10606428", "map_id": "Q93518", "name": "10xCbxE-F2(25-622)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10613073", "map_id": "none", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613049", "map_id": "none", "name": "Dhp-K50-EIF5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20751", "map_id": "Q20751", "name": "iff-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002065", "map_id": "WBGene00002065", "name": "iff-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34563", "map_id": "P34563", "name": "iff-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002064", "map_id": "WBGene00002064", "name": "iff-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613063", "map_id": "none", "name": "EIF5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10613070", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXJ0", "map_id": "Q9XXJ0", "name": "dhps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012460", "map_id": "WBGene00012460", "name": "dhps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606678", "map_id": "none", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10606670", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(31-691)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10650386", "map_id": "none", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788868", "map_id": "none", "name": "ketoamines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:24103", "map_id": "CHEBI:24103", "name": "CHEBI:24103", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788848", "map_id": "none", "name": "ketosamines 3-phosphate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:87178", "map_id": "CHEBI:87178", "name": "CHEBI:87178", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643332", "map_id": "none", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643324", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605934", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643329", "map_id": "Q966L4", "name": "DPH6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017087", "map_id": "WBGene00017087", "name": "DPH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613101", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613091", "map_id": "none", "name": "Hyp-K50-EIF5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10613098", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17949", "map_id": "Q17949", "name": "dohh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007555", "map_id": "WBGene00007555", "name": "dohh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648553", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648541", "map_id": "none", "name": "PCNA homotrimer,MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598185", "map_id": "none", "name": "RFC Heteropentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648539", "map_id": "none", "name": "POLD,POLE,POLK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34409", "map_id": "P34409", "name": "polk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017696", "map_id": "WBGene00017696", "name": "polk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648537", "map_id": "none", "name": "GG-NER incision complex:5'-incised damaged DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N3L2", "map_id": "Q9N3L2", "name": "xpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021752", "map_id": "WBGene00021752", "name": "xpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93456", "map_id": "Q93456", "name": "ercc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008665", "map_id": "WBGene00008665", "name": "ercc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44499", "map_id": "O44499", "name": "gtf-2h1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019821", "map_id": "WBGene00019821", "name": "gtf-2h1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09645", "map_id": "Q09645", "name": "gtf-2h3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014230", "map_id": "WBGene00014230", "name": "gtf-2h3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N390", "map_id": "Q9N390", "name": "gtf-2h5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021904", "map_id": "WBGene00021904", "name": "gtf-2h5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21554", "map_id": "Q21554", "name": "ddb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010890", "map_id": "WBGene00010890", "name": "ddb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8F7X5", "map_id": "K8F7X5", "name": "gft-2H4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013529", "map_id": "WBGene00013529", "name": "gft-2H4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ4", "map_id": "Q95PZ4", "name": "xpb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013441", "map_id": "WBGene00013441", "name": "xpb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBZ1", "map_id": "G5EBZ1", "name": "xpf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008140", "map_id": "WBGene00008140", "name": "xpf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17392", "map_id": "Q17392", "name": "cul-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000839", "map_id": "WBGene00000839", "name": "cul-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21302", "map_id": "Q21302", "name": "xpa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006963", "map_id": "WBGene00006963", "name": "xpa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34567", "map_id": "P34567", "name": "gtf-2H2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011814", "map_id": "WBGene00011814", "name": "gtf-2H2C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4H4", "map_id": "Q9N4H4", "name": "parp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004049", "map_id": "WBGene00004049", "name": "parp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648551", "map_id": "none", "name": "GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648672", "map_id": "none", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648669", "map_id": "none", "name": "GG-NER incision complex:Open bubble dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663517", "map_id": "none", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616067", "map_id": "G5EFX6", "name": "slt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00004854", "map_id": "WBGene00004854", "name": "slt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636623", "map_id": "none", "name": "Dystroglycan", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22629", "map_id": "Q22629", "name": "dgn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000961", "map_id": "WBGene00000961", "name": "dgn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61756", "map_id": "O61756", "name": "dgn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018943", "map_id": "WBGene00018943", "name": "dgn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663515", "map_id": "none", "name": "SLIT2:Dystroglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFX6", "map_id": "G5EFX6", "name": "slt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657351", "map_id": "none", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_6814303", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10631004", "map_id": "Q95YD2", "name": "PLA2G6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016661", "map_id": "WBGene00016661", "name": "PLA2G6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657483", "map_id": "none", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10657445", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q09248", "map_id": "Q09248", "name": "dnc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001018", "map_id": "WBGene00001018", "name": "dnc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2JKZ0", "map_id": "E2JKZ0", "name": "dnc-1", "type": "complex_component", 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"compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016124", "map_id": "WBGene00016124", "name": "dnc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34686", "map_id": "P34686", "name": "cap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000293", "map_id": "WBGene00000293", "name": "cap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYR2", "map_id": "Q9GYR2", "name": "arp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016793", "map_id": "WBGene00016793", "name": "arp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I136", "map_id": "Q8I136", "name": "gly-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001629", "map_id": "WBGene00001629", "name": "gly-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34685", "map_id": "P34685", "name": "cap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000292", "map_id": "WBGene00000292", "name": "cap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34213", "map_id": "P34213", "name": "rab-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004269", "map_id": "WBGene00004269", "name": "rab-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA98", "map_id": "Q9NA98", "name": "arp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013168", "map_id": "WBGene00013168", "name": "arp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657463", "map_id": "none", "name": "RAB6:GTP:COPI-independent retrograde Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10656090", "map_id": "none", "name": "Dynein:Dynactin:microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10657432", "map_id": "none", "name": "BICD dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10657481", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8MXS1", "map_id": "Q8MXS1", "name": "rab-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004277", "map_id": "WBGene00004277", "name": "rab-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22670", "map_id": "Q22670", "name": "rbg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004318", "map_id": "WBGene00004318", "name": "rbg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93538", "map_id": "Q93538", "name": "rbg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004317", "map_id": "WBGene00004317", "name": "rbg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657547", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10657543", "map_id": "none", "name": "RAB18:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10657475", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10657545", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10656574", "map_id": "none", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10656558", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9N4H7", "map_id": "Q9N4H7", "name": "copa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022119", "map_id": "WBGene00022119", "name": "copa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09654", "map_id": "Q09654", "name": "arc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000180", "map_id": "WBGene00000180", "name": "arc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09236", "map_id": "Q09236", "name": "copd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015734", "map_id": "WBGene00015734", "name": "copd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10943", "map_id": "Q10943", "name": "arf-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000182", "map_id": "WBGene00000182", "name": "arf-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAQ6", "map_id": "Q9UAQ6", "name": "rab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004266", "map_id": "WBGene00004266", "name": "rab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20168", "map_id": "Q20168", "name": "copb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009542", "map_id": "WBGene00009542", "name": "copb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFK4", "map_id": "G5EFK4", "name": "arf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000183", "map_id": "WBGene00000183", "name": "arf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62246", "map_id": "O62246", "name": "cope-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009732", "map_id": "WBGene00009732", "name": "cope-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94231", "map_id": "Q94231", "name": "arf-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000190", "map_id": "WBGene00000190", "name": "arf-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22498", "map_id": "Q22498", "name": "copg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011775", "map_id": "WBGene00011775", "name": "copg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGS5", "map_id": "G5EGS5", "name": "gbf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007703", "map_id": "WBGene00007703", "name": "gbf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYL9", "map_id": "Q9TYL9", "name": "copb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021292", "map_id": "WBGene00021292", "name": "copb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17901", "map_id": "O17901", "name": "copz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010333", "map_id": "WBGene00010333", "name": "copz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655931", "map_id": "none", "name": "ARFGAP1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09531", "map_id": "Q09531", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017217", "map_id": "WBGene00017217", "name": "ARFGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90904", "map_id": "P90904", "name": "ARFGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010500", "map_id": "WBGene00010500", "name": "ARFGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656284", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O44738", "map_id": "O44738", "name": "tmed-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019003", "map_id": "WBGene00019003", "name": "tmed-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17528", "map_id": "O17528", "name": "sel-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004766", "map_id": "WBGene00004766", "name": "sel-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20546", "map_id": "Q20546", "name": "tmed-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009829", "map_id": "WBGene00009829", "name": "tmed-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656560", "map_id": "Q94241", "name": "sec-22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00018853", "map_id": "WBGene00018853", "name": "sec-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656570", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18864", "map_id": "Q18864", "name": "sft-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004788", "map_id": "WBGene00004788", "name": "sft-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48583", "map_id": "P48583", "name": "erd-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001331", "map_id": "WBGene00001331", "name": "erd-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09473", "map_id": "Q09473", "name": "erd-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016195", "map_id": "WBGene00016195", "name": "erd-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656572", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q94241", "map_id": "Q94241", "name": "sec-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656616", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10649229", "map_id": "none", "name": "SNAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18921", "map_id": "Q18921", "name": "snap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017016", "map_id": "WBGene00017016", "name": "snap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1RPT8", "map_id": "Q1RPT8", "name": "NAPG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044794", "map_id": "WBGene00044794", "name": "NAPG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEQ8", "map_id": "Q9NEQ8", "name": "NAPG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649213", "map_id": "none", "name": "NSF hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94392", "map_id": "Q94392", "name": "nsf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003818", "map_id": "WBGene00003818", "name": "nsf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656614", "map_id": "none", "name": "SEC22B:STX18:USE1L:BNIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9N598", "map_id": "Q9N598", "name": "USE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022460", "map_id": "WBGene00022460", "name": "USE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0Z1Y7", "map_id": "C0Z1Y7", "name": "sec-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018239", "map_id": "WBGene00018239", "name": "sec-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76413", "map_id": "O76413", "name": "syx-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020425", "map_id": "WBGene00020425", "name": "syx-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656607", "map_id": "none", "name": "SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10657436", "map_id": "none", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10657419", "map_id": "none", "name": "COPI-independent Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10657417", "map_id": "none", "name": "RAB6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10657434", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656702", "map_id": "none", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10656700", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19642", "map_id": "Q19642", "name": "czw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017643", "map_id": "WBGene00017643", "name": "czw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90841", "map_id": "P90841", "name": "smgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008990", "map_id": "WBGene00008990", "name": "smgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649098", "map_id": "none", "name": "RAB1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10656652", "map_id": "none", "name": "p24 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10655913", "map_id": "none", "name": "coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10656698", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10657447", "map_id": "none", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10657443", "map_id": "none", "name": "Dynein:Dynactin:microtubules:PAFAH1B1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NDC9", "map_id": "Q9NDC9", "name": "lis-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003047", "map_id": "WBGene00003047", "name": "lis-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657441", "map_id": "Q9NDC9", "name": "lis-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10656554", "map_id": "none", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10656258", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10655846", "map_id": "G5EGS5", "name": "gbf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656552", "map_id": "none", "name": "RAB1:GTP:GBF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656610", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10656598", "map_id": "O76413", "name": "syx-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10656603", "map_id": "Q9N598", "name": "USE1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10612598", "map_id": "Q94241", "name": "sec-22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10656593", "map_id": "C0Z1Y7", "name": "sec-20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10657550", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10656618", "map_id": "none", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10628218", "map_id": "none", "name": "Kinesins:microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965T6", "map_id": "Q965T6", "name": "klp-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002230", "map_id": "WBGene00002230", "name": "klp-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46873", "map_id": "P46873", "name": "osm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003884", "map_id": "WBGene00003884", "name": "osm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGS3", "map_id": "G5EGS3", "name": "klp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002223", "map_id": "WBGene00002223", "name": "klp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19633", "map_id": "Q19633", "name": "klp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002222", "map_id": "WBGene00002222", "name": "klp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34540", "map_id": "P34540", "name": "unc-116", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006840", "map_id": "WBGene00006840", "name": "unc-116", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2T2", "map_id": "H9G2T2", "name": "klc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002214", "map_id": "WBGene00002214", "name": "klc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS9", "map_id": "Q9XUS9", "name": "cyk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000875", "map_id": "WBGene00000875", "name": "cyk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU12", "map_id": "Q9XU12", "name": "klp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002219", "map_id": "WBGene00002219", "name": "klp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ03", "map_id": "Q8MQ03", "name": "zen-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006974", "map_id": "WBGene00006974", "name": "zen-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45935", "map_id": "O45935", "name": "klp-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002229", "map_id": "WBGene00002229", "name": "klp-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ20", "map_id": "Q8MQ20", "name": "klp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002217", "map_id": "WBGene00002217", "name": "klp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46822", "map_id": "P46822", "name": "klc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002215", "map_id": "WBGene00002215", "name": "klc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE6", "map_id": "G5EEE6", "name": "kap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002182", "map_id": "WBGene00002182", "name": "kap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23678", "map_id": "P23678", "name": "unc-104", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006831", "map_id": "WBGene00006831", "name": "unc-104", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECF4", "map_id": "G5ECF4", "name": "bmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000257", "map_id": "WBGene00000257", "name": "bmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IKG7", "map_id": "A0A4V0IKG7", "name": "klp-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002224", "map_id": "WBGene00002224", "name": "klp-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBX0", "map_id": "G5EBX0", "name": "klp-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002228", "map_id": "WBGene00002228", "name": "klp-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656588", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "species_10656612", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10647110", "map_id": "none", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647066", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EE56", "map_id": "G5EE56", "name": "src-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEW9", "map_id": "G5EEW9", "name": "cnk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000564", "map_id": "WBGene00000564", "name": "cnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17772", "map_id": "O17772", "name": "pes-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003980", "map_id": "WBGene00003980", "name": "pes-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFD2", "map_id": "G5EFD2", "name": "ksr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002239", "map_id": "WBGene00002239", "name": "ksr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P51485", "map_id": "P51485", "name": "arr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000195", "map_id": "WBGene00000195", "name": "arr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34400", "map_id": "P34400", "name": "mig-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003243", "map_id": "WBGene00003243", "name": "mig-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGK1", "map_id": "G5EGK1", "name": "tln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006771", "map_id": "WBGene00006771", "name": "tln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECJ6", "map_id": "G5ECJ6", "name": "csk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000812", "map_id": "WBGene00000812", "name": "csk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDA5", "map_id": "G5EDA5", "name": "ksr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002240", "map_id": "WBGene00002240", "name": "ksr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19826", "map_id": "P19826", "name": "deb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000942", "map_id": "WBGene00000942", "name": "deb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10984", "map_id": "P10984", "name": "act-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000064", "map_id": "WBGene00000064", "name": "act-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647091", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10647098", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=9909", "map_id": "LigandDisplayForward?ligandId=9909", "name": "LigandDisplayForward?ligandId=9909", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6495", "map_id": "LigandDisplayForward?ligandId=6495", "name": "LigandDisplayForward?ligandId=6495", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:16719221", "map_id": "pubchem.compound:16719221", "name": "pubchem.compound:16719221", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647108", "map_id": "none", "name": "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=8943", "map_id": "LigandDisplayForward?ligandId=8943", "name": "LigandDisplayForward?ligandId=8943", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10387", "map_id": "LigandDisplayForward?ligandId=10387", "name": "LigandDisplayForward?ligandId=10387", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9977", "map_id": "LigandDisplayForward?ligandId=9977", "name": "LigandDisplayForward?ligandId=9977", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647102", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647093", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10647096", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7935", "map_id": "LigandDisplayForward?ligandId=7935", "name": "LigandDisplayForward?ligandId=7935", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5676", "map_id": "LigandDisplayForward?ligandId=5676", "name": "LigandDisplayForward?ligandId=5676", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5665", "map_id": "LigandDisplayForward?ligandId=5665", "name": "LigandDisplayForward?ligandId=5665", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7942", "map_id": "LigandDisplayForward?ligandId=7942", "name": "LigandDisplayForward?ligandId=7942", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7921", "map_id": "LigandDisplayForward?ligandId=7921", "name": "LigandDisplayForward?ligandId=7921", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7626", "map_id": "LigandDisplayForward?ligandId=7626", "name": "LigandDisplayForward?ligandId=7626", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7872", "map_id": "LigandDisplayForward?ligandId=7872", "name": "LigandDisplayForward?ligandId=7872", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647100", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=9974", "map_id": "LigandDisplayForward?ligandId=9974", "name": "LigandDisplayForward?ligandId=9974", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8056", "map_id": "LigandDisplayForward?ligandId=8056", "name": "LigandDisplayForward?ligandId=8056", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665556", "map_id": "none", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657567", "map_id": "none", "name": "dual mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647155", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10647145", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q19986", "map_id": "Q19986", "name": "wdr-83", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018014", "map_id": "WBGene00018014", "name": "wdr-83", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQG5", "map_id": "Q8WQG5", "name": "lmtr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007390", "map_id": "WBGene00007390", "name": "lmtr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2U6", "map_id": "Q9N2U6", "name": "lmtr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022402", "map_id": "WBGene00022402", "name": "lmtr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647147", "map_id": "none", "name": "activated RAF homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647149", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10665558", "map_id": "none", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657570", "map_id": "none", "name": "dual mechanism MAPK inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647113", "map_id": "none", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647054", "map_id": "none", "name": "RAF/MAPK scaffolds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647068", "map_id": "none", "name": "p21RAS:GTP:activated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665560", "map_id": "none", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657574", "map_id": "none", "name": "single mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647185", "map_id": "none", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10647178", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:MAPKs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9NA64", "map_id": "Q9NA64", "name": "ilcr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013415", "map_id": "WBGene00013415", "name": "ilcr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10128", "map_id": "Q10128", "name": "ilcr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018960", "map_id": "WBGene00018960", "name": "ilcr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647182", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10647077", "map_id": "none", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647030", "map_id": "none", "name": "p21 RAS:GTP:activated RAF homo/heterodimer complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10647075", "map_id": "none", "name": "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16264", "map_id": "O16264", "name": "PEBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018218", "map_id": "WBGene00018218", "name": "PEBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647180", "map_id": "none", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10647176", "map_id": "none", "name": "Homologues of IL17RD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10665564", "map_id": "none", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657577", "map_id": "none", "name": "single mechanism MAPK inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=9210", "map_id": "LigandDisplayForward?ligandId=9210", "name": "LigandDisplayForward?ligandId=9210", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9375", "map_id": "LigandDisplayForward?ligandId=9375", "name": "LigandDisplayForward?ligandId=9375", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9229", "map_id": "LigandDisplayForward?ligandId=9229", "name": "LigandDisplayForward?ligandId=9229", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665562", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10647153", "map_id": "none", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10647151", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10630903", "map_id": "none", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524047", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524038", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524042", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10630900", "map_id": "O01916", "name": "crls-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00017763", "map_id": "WBGene00017763", "name": "crls-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630925", "map_id": "none", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630892", "map_id": "A0A486WXW2", "name": "acl-14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00019465", "map_id": "WBGene00019465", "name": "acl-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630895", "map_id": "none", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10631927", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602402", "map_id": "CHEBI:17517", "name": "PG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1602415", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10631910", "map_id": "none", "name": "PLA2G12A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18339", "map_id": "Q18339", "name": "PLA2G12A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016288", "map_id": "WBGene00016288", "name": "PLA2G12A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10631925", "map_id": "none", "name": "Homologues of PLA2R1(21-?)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P34312", "map_id": "P34312", "name": "clec-162", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007399", "map_id": "WBGene00007399", "name": "clec-162", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17452", "map_id": "Q17452", "name": "clec-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015052", "map_id": "WBGene00015052", "name": "clec-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34472", "map_id": "P34472", "name": "clec-161", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010228", "map_id": "WBGene00010228", "name": "clec-161", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17450", "map_id": "Q17450", "name": "clec-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015050", "map_id": "WBGene00015050", "name": "clec-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22591", "map_id": "Q22591", "name": "clec-178", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020585", "map_id": "WBGene00020585", "name": "clec-178", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91429", "map_id": "P91429", "name": "clec-53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020191", "map_id": "WBGene00020191", "name": "clec-53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630962", "map_id": "none", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524027", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10657697", "map_id": "none", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647007", "map_id": "none", "name": "HGF:p-4Y-MET dimer:RANBP9:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XWK4", "map_id": "Q9XWK4", "name": "RANBP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013202", "map_id": "WBGene00013202", "name": "RANBP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657694", "map_id": "none", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647009", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10642565", "map_id": "none", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_5221122", "map_id": "CHEBI:29089", "name": "1,2-diacyl-glycerol 3-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10641096", "map_id": "Q9XXT5", "name": "lpin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "WBGene00010425", "map_id": "WBGene00010425", "name": "lpin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642747", "map_id": "none", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642729", "map_id": "none", "name": "p-S395-Lamin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21443", "map_id": "Q21443", "name": "lmn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003052", "map_id": "WBGene00003052", "name": "lmn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642745", "map_id": "none", "name": "p-S22/23, S395-Lamin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10607621", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q10653", "map_id": "Q10653", "name": "cyb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000865", "map_id": "WBGene00000865", "name": "cyb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BLB5", "map_id": "Q9BLB5", "name": "cyb-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000867", "map_id": "WBGene00000867", "name": "cyb-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45926", "map_id": "O45926", "name": "cyb-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000866", "map_id": "WBGene00000866", "name": "cyb-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34556", "map_id": "P34556", "name": "phospho-cdk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000405", "map_id": "WBGene00000405", "name": "phospho-cdk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642573", "map_id": "none", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_29496", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10642567", "map_id": "P90980", "name": "phospho-pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10642571", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10642190", "map_id": "none", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641090", "map_id": "Q9XXT5", "name": "phospho-lpin-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10641115", "map_id": "none", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10641112", "map_id": "none", "name": "CTDNEP1:CNEP1R1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9XXN3", "map_id": "Q9XXN3", "name": "nepr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011828", "map_id": "WBGene00011828", "name": "nepr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20432", "map_id": "Q20432", "name": "cnep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018474", "map_id": "WBGene00018474", "name": "cnep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638146", "map_id": "none", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638130", "map_id": "none", "name": "Nuclear Pore Complex (p-2S,3T-NUP98)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10607633", "map_id": "none", "name": "CCNB1,CCNB2:p-T161-CDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10651289", "map_id": "none", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10651285", "map_id": "none", "name": "Protein 4.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KZV9", "map_id": "H2KZV9", "name": "frm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001489", "map_id": "WBGene00001489", "name": "frm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEG8", "map_id": "G5EEG8", "name": "frm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001488", "map_id": "WBGene00001488", "name": "frm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617017", "map_id": "P54936", "name": "lin-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002991", "map_id": "WBGene00002991", "name": "lin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651287", "map_id": "none", "name": "CASK:Protein 4.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54936", "map_id": "P54936", "name": "lin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651323", "map_id": "none", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10651319", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "I2HAJ6", "map_id": "I2HAJ6", "name": "nrx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007799", "map_id": "WBGene00007799", "name": "nrx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1T5HV05", "map_id": "A0A1T5HV05", "name": "DLGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020970", "map_id": "WBGene00020970", "name": "DLGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7WN72", "map_id": "B7WN72", "name": "shn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006444", "map_id": "WBGene00006444", "name": "shn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTG1", "map_id": "Q9XTG1", "name": "nlg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006412", "map_id": "WBGene00006412", "name": "nlg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20826", "map_id": "Q20826", "name": "glit-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018878", "map_id": "WBGene00018878", "name": "glit-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612288", "map_id": "Q9XUT0", "name": "dbn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010664", "map_id": "WBGene00010664", "name": "dbn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651321", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUT0", "map_id": "Q9XUT0", "name": "dbn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617553", "map_id": "none", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617549", "map_id": "none", "name": "PTPRF, PTPRS, PTPRD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95Y26", "map_id": "Q95Y26", "name": "ptpn-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021507", "map_id": "WBGene00021507", "name": "ptpn-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17889", "map_id": "O17889", "name": "PTPRF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044348", "map_id": "WBGene00044348", "name": "PTPRF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGU2", "map_id": "G5EGU2", "name": "eak-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008663", "map_id": "WBGene00008663", "name": "eak-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XL1", "map_id": "Q95XL1", "name": "PTPRF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28192", "map_id": "P28192", "name": "ptp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010558", "map_id": "WBGene00010558", "name": "ptp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BMN8", "map_id": "Q9BMN8", "name": "ptp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004215", "map_id": "WBGene00004215", "name": "ptp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W6RR46", "map_id": "W6RR46", "name": "PTPRF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22852", "map_id": "Q22852", "name": "PTPRF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01736", "map_id": "O01736", "name": "PTPRF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGA9", "map_id": "G5EGA9", "name": "sdf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004748", "map_id": "WBGene00004748", "name": "sdf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617493", "map_id": "none", "name": "Liprins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21049", "map_id": "Q21049", "name": "syd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006364", "map_id": "WBGene00006364", "name": "syd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94071", "map_id": "Q94071", "name": "hlb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011904", "map_id": "WBGene00011904", "name": "hlb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617551", "map_id": "none", "name": "LAR,PTPRS,PTPRD:Liprins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10651237", "map_id": "none", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10651191", "map_id": "I2HAJ6", "name": "nrx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10651233", "map_id": "none", "name": "NLGN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10651235", "map_id": "none", "name": "NRXNs:NLGN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10651327", "map_id": "none", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10651325", "map_id": "none", "name": "NRXNs:NLGN dimers:CASK:Protein 4.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657531", "map_id": "none", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620856", "map_id": "G5ECY0", "name": "dlg-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10657527", "map_id": "none", "name": "NMDA receptor complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGQ9", "map_id": "G5EGQ9", "name": "nmr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003774", "map_id": "WBGene00003774", "name": "nmr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEH3", "map_id": "G5EEH3", "name": "phospho-nmr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003775", "map_id": "WBGene00003775", "name": "phospho-nmr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657529", "map_id": "none", "name": "NMDAR:PSD-95", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10644074", "map_id": "none", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00012361", "map_id": "WBGene00012361", "name": "mrpl-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22140", "map_id": "Q22140", "name": "mrpl-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011412", "map_id": "WBGene00011412", "name": "mrpl-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34748", "map_id": "P34748", "name": "mrps-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014224", "map_id": "WBGene00014224", "name": "mrps-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76606", "map_id": "O76606", "name": "mrpl-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020796", "map_id": "WBGene00020796", "name": "mrpl-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34378", "map_id": "P34378", "name": "mrpl-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017044", "map_id": "WBGene00017044", "name": "mrpl-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22483", "map_id": "Q22483", "name": "mrps-18.c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020499", "map_id": "WBGene00020499", "name": "mrps-18.c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10129", "map_id": "Q10129", "name": "mrps-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018961", "map_id": "WBGene00018961", "name": "mrps-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QS3", "map_id": "Q95QS3", "name": "mrps-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016412", "map_id": "WBGene00016412", "name": "mrps-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02220", "map_id": "O02220", "name": "mrpl-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007712", "map_id": "WBGene00007712", "name": "mrpl-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49404", "map_id": "P49404", "name": "mrps-18C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016142", "map_id": "WBGene00016142", "name": "mrps-18C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18199", "map_id": "O18199", "name": "mrpl-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013004", "map_id": "WBGene00013004", "name": "mrpl-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC8", "map_id": "G5EFC8", "name": "dap-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000933", "map_id": "WBGene00000933", "name": "dap-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W5T0", "map_id": "Q4W5T0", "name": "mrpl-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044344", "map_id": "WBGene00044344", "name": "mrpl-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23155", "map_id": "Q23155", "name": "mrps-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012244", "map_id": "WBGene00012244", "name": "mrps-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YX52", "map_id": "Q7YX52", "name": "mrpl-53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008459", "map_id": "WBGene00008459", "name": "mrpl-53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44133", "map_id": "O44133", "name": "CHCHD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016057", "map_id": "WBGene00016057", "name": "CHCHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09261", "map_id": "Q09261", "name": "mrps-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007859", "map_id": "WBGene00007859", "name": "mrps-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYJ8", "map_id": "Q9TYJ8", "name": "mrpl-55", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022045", "map_id": "WBGene00022045", "name": "mrpl-55", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWP0", "map_id": "Q9XWP0", "name": "mrps-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012830", "map_id": "WBGene00012830", "name": "mrps-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q688C0", "map_id": "Q688C0", "name": "mrps-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023487", "map_id": "WBGene00023487", "name": "mrps-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644072", "map_id": "none", "name": "55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10644103", "map_id": "none", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10644078", "map_id": "none", "name": "55S ribosome:mRNA:tRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10644092", "map_id": "P91478", "name": "mrrf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00020625", "map_id": "WBGene00020625", "name": "mrrf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644101", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:MRRF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P91478", "map_id": "P91478", "name": "mrrf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644080", "map_id": "none", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113525", "map_id": "CHEBI:58189", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5419287", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10644099", "map_id": "none", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10644094", "map_id": "none", "name": "55S ribosome:MRRF:GFM2:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q95Y73", "map_id": "Q95Y73", "name": "fusm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022491", "map_id": "WBGene00022491", "name": "fusm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643799", "map_id": "none", "name": "28S ribosomal subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10644096", "map_id": "none", "name": "GFM2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10644042", "map_id": "none", "name": "39S ribosomal subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10644059", "map_id": "none", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10644055", "map_id": "none", "name": "GFM1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XV52", "map_id": "Q9XV52", "name": "gfm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009246", "map_id": "WBGene00009246", "name": "gfm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644048", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10644057", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10630939", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10630936", "map_id": "none", "name": "LPSAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "H9G2W5", "map_id": "H9G2W5", "name": "mboa-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007446", "map_id": "WBGene00007446", "name": "mboa-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC53", "map_id": "G5EC53", "name": "mboa-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016934", "map_id": "WBGene00016934", "name": "mboa-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01925", "map_id": "O01925", "name": "mboa-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020115", "map_id": "WBGene00020115", "name": "mboa-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659187", "map_id": "none", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_33625", "map_id": "CHEBI:18303", "name": "PS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10659184", "map_id": "Q8MPR9", "name": "obr-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00014215", "map_id": "WBGene00014215", "name": "obr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630965", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10631930", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602419", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10663355", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10663347", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9BKS0", "map_id": "Q9BKS0", "name": "ATP5G1(1-61)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022336", "map_id": "WBGene00022336", "name": "ATP5G1(1-61)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7J4", "map_id": "Q8I7J4", "name": "coq-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000762", "map_id": "WBGene00000762", "name": "coq-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWJ5", "map_id": "Q9XWJ5", "name": "NDUFB8(1-28)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013094", "map_id": "WBGene00013094", "name": "NDUFB8(1-28)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46561", "map_id": "P46561", "name": "atp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000229", "map_id": "WBGene00000229", "name": "atp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4K2", "map_id": "Q8I4K2", "name": "Q8I4K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009334", "map_id": "WBGene00009334", "name": "Q8I4K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663352", "map_id": "Q22370", "name": "ucr-2.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00011679", "map_id": "WBGene00011679", "name": "ucr-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625828", "map_id": "none", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9707310", "map_id": "none", "name": "Hemes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_71185", "map_id": "CHEBI:17627", "name": "heme", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:36144", "map_id": "CHEBI:36144", "name": "CHEBI:36144", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9707308", "map_id": "none", "name": "Hemes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611603", "map_id": "none", "name": "Homologues of SLC46A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XWL3", "map_id": "Q9XWL3", "name": "slcr-46.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012811", "map_id": "WBGene00012811", "name": "slcr-46.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20236", "map_id": "Q20236", "name": "slcr-46.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009582", "map_id": "WBGene00009582", "name": "slcr-46.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAZ6", "map_id": "Q9UAZ6", "name": "slc-46a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021159", "map_id": "WBGene00021159", "name": "slc-46a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZC0", "map_id": "H2KZC0", "name": "slcr-46.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016705", "map_id": "WBGene00016705", "name": "slcr-46.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629240", "map_id": "none", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601707", "map_id": "O45017", "name": "TXN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020917", "map_id": "WBGene00020917", "name": "2xHC-TXN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601705", "map_id": "O45017", "name": "2xHC-TXN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10629211", "map_id": "none", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629198", "map_id": "none", "name": "p38 MAPK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10629208", "map_id": "none", "name": "Phospho-p38 MAPK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622456", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10634116", "map_id": "none", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10634100", "map_id": "none", "name": "NOTCH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P41990", "map_id": "P41990", "name": "phospho-apx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000168", "map_id": "WBGene00000168", "name": "phospho-apx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634109", "map_id": "none", "name": "NOTCH4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10634114", "map_id": "O17528", "name": "sel-9", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10664120", "map_id": "none", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10664115", "map_id": "G5EC57", "name": "svh-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006462", "map_id": "WBGene00006462", "name": "svh-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664117", "map_id": "Q19266", "name": "pkc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004034", "map_id": "WBGene00004034", "name": "phospho-pkc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629322", "map_id": "none", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629255", "map_id": "none", "name": "ERBB4m80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P24348", "map_id": "P24348", "name": "let-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002299", "map_id": "WBGene00002299", "name": "let-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10629265", "map_id": "none", "name": "ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10629319", "map_id": "none", "name": "gamma-secretase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O02100", "map_id": "O02100", "name": "hop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001985", "map_id": "WBGene00001985", "name": "hop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45876", "map_id": "O45876", "name": "aph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000147", "map_id": "WBGene00000147", "name": "aph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U357", "map_id": "Q9U357", "name": "pen-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003975", "map_id": "WBGene00003975", "name": "pen-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23316", "map_id": "Q23316", "name": "aph-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000148", "map_id": "WBGene00000148", "name": "aph-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q01608", "map_id": "Q01608", "name": "spe-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004958", "map_id": "WBGene00004958", "name": "spe-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52166", "map_id": "P52166", "name": "sel-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004769", "map_id": "WBGene00004769", "name": "sel-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629346", "map_id": "none", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629341", "map_id": "none", "name": "ERBB4/m80/s80:WWP1/ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10629343", "map_id": "none", "name": "Ub-ERBB4:WWP1/ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629372", "map_id": "none", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629362", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008748", "map_id": "WBGene00008748", "name": "yap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10629364", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19404", "map_id": "Q19404", "name": "yap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629357", "map_id": "none", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629353", "map_id": "Q95QN9", "name": "WWOX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017131", "map_id": "WBGene00017131", "name": "WWOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10629355", "map_id": "none", "name": "ERBB4s80:WWOX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95QN9", "map_id": "Q95QN9", "name": "WWOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629396", "map_id": "none", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629384", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10629394", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10629370", "map_id": "none", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629368", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10629398", "map_id": "none", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629382", "map_id": "none", "name": "p-Y694-STAT5A homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664835", "map_id": "none", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615184", "map_id": "G5EE56", "name": "phospho-src-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10629334", "map_id": "none", "name": "ERBB4s80:MyrG-p-Y419-SRC", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629348", "map_id": "none", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627496", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629339", "map_id": "none", "name": "ERBB4/ERBB4m80/ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10629410", "map_id": "none", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629408", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10634331", "map_id": "none", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10634324", "map_id": "none", "name": "ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10634328", "map_id": "none", "name": "Ub-ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10629336", "map_id": "none", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629332", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10634326", "map_id": "none", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629259", "map_id": "none", "name": "ERBB4jmAcyt1s80 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605846", "map_id": "none", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605835", "map_id": "Q09373", "name": "fzy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001511", "map_id": "WBGene00001511", "name": "fzy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605840", "map_id": "Q9NGT3", "name": "mdf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003161", "map_id": "WBGene00003161", "name": "mdf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605844", "map_id": "none", "name": "MAD2*CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NGT3", "map_id": "Q9NGT3", "name": "mdf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09373", "map_id": "Q09373", "name": "fzy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605848", "map_id": "none", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605825", "map_id": "none", "name": "Homologues of BUB1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21776", "map_id": "Q21776", "name": "bub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000275", "map_id": "WBGene00000275", "name": "bub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02053", "map_id": "O02053", "name": "san-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004721", "map_id": "WBGene00004721", "name": "san-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605830", "map_id": "Q9XWH0", "name": "bub-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013209", "map_id": "WBGene00013209", "name": "bub-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605842", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2*:CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XWH0", "map_id": "Q9XWH0", "name": "bub-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607997", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607992", "map_id": "Q09649", "name": "fzr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001510", "map_id": "WBGene00001510", "name": "fzr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607994", "map_id": "Q09649", "name": "phospho-fzr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605577", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605570", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "Q9Y0A1", "map_id": "Q9Y0A1", "name": "itr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002173", "map_id": "WBGene00002173", "name": "itr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605572", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10619745", "map_id": "none", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619741", "map_id": "none", "name": "TRPC3/6/7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34586", "map_id": "P34586", "name": "trp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006614", "map_id": "WBGene00006614", "name": "trp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF09", "map_id": "G5EF09", "name": "spe-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004976", "map_id": "WBGene00004976", "name": "spe-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619743", "map_id": "none", "name": "DAG-activated TRPC3/6/7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619520", "map_id": "none", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610919", "map_id": "none", "name": "PKC-delta/epsilon", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34885", "map_id": "P34885", "name": "pkc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004032", "map_id": "WBGene00004032", "name": "pkc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34722", "map_id": "P34722", "name": "phospho-tpa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006599", "map_id": "WBGene00006599", "name": "phospho-tpa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619518", "map_id": "none", "name": "Protein kinase C, novel isoforms:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10649353", "map_id": "none", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694509", "map_id": "CHEBI:75571", "name": "3AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_422506", "map_id": "CHEBI:15843", "name": "AA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10649350", "map_id": "Q965S2", "name": "abhd-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00022393", "map_id": "WBGene00022393", "name": "abhd-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605575", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "reaction_10619788", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619785", "map_id": "none", "name": "Diacylglycerol kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KZC9", "map_id": "H2KZC9", "name": "dgk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006483", "map_id": "WBGene00006483", "name": "dgk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03603", "map_id": "Q03603", "name": "dgk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000960", "map_id": "WBGene00000960", "name": "dgk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYI9", "map_id": "H2KYI9", "name": "dgk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000959", "map_id": "WBGene00000959", "name": "dgk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17860", "map_id": "Q17860", "name": "dgk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000958", "map_id": "WBGene00000958", "name": "dgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10024", "map_id": "Q10024", "name": "dgk-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019428", "map_id": "WBGene00019428", "name": "dgk-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619647", "map_id": "none", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426026", "map_id": "CHEBI:35366", "name": "Fatty Acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426030", "map_id": "CHEBI:52392", "name": "2AG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10619644", "map_id": "H2KY93", "name": "dagl-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00018364", "map_id": "WBGene00018364", "name": "dagl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650309", "map_id": "none", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788291", "map_id": "CHEBI:18116", "name": "PURIDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788290", "map_id": "CHEBI:17802", "name": "PURID", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10650306", "map_id": "none", "name": "HDHD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EG26", "map_id": "G5EG26", "name": "R151.8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020113", "map_id": "WBGene00020113", "name": "R151.8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602217", "map_id": "none", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_112016", "map_id": "CHEBI:57720", "name": "R1P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:58576", "map_id": "CHEBI:58576", "name": "CHEBI:58576", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83962", "map_id": "CHEBI:17568", "name": "Ura", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602214", "map_id": "none", "name": "UPP1, UPP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23588", "map_id": "Q23588", "name": "upp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022817", "map_id": "WBGene00022817", "name": "upp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601699", "map_id": "none", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83928", "map_id": "CHEBI:17748", "name": "Thy-dRib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:63528", "name": "TMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10601696", "map_id": "none", "name": "TK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEZ5", "map_id": "G5EEZ5", "name": "thk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006568", "map_id": "WBGene00006568", "name": "thk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662627", "map_id": "none", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_727810", "map_id": "CHEBI:60377", "name": "CMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10662624", "map_id": "H2L2A8", "name": "UCKL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008948", "map_id": "WBGene00008948", "name": "UCKL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601683", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601680", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20628", "map_id": "Q20628", "name": "cdd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000392", "map_id": "WBGene00000392", "name": "cdd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601663", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601660", "map_id": "none", "name": "UCK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17413", "map_id": "Q17413", "name": "UCK 2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007089", "map_id": "WBGene00007089", "name": "UCK 2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604531", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604528", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604921", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604918", "map_id": "none", "name": "activated PDE1 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18696", "map_id": "O18696", "name": "pde-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011433", "map_id": "WBGene00011433", "name": "pde-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661713", "map_id": "none", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604862", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604864", "map_id": "none", "name": "PKA tetramer:4xcAMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621546", "map_id": "none", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621538", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q3Y416", "map_id": "Q3Y416", "name": "phospho-ckk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000518", "map_id": "WBGene00000518", "name": "phospho-ckk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621543", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604963", "map_id": "none", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10604936", "map_id": "Q09639", "name": "grk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00001709", "map_id": "WBGene00001709", "name": "phospho-grk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604960", "map_id": "Q09639", "name": "phospho-grk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10604954", "map_id": "none", "name": "active PKC (alpha, gamma, delta)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604900", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10604895", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10604898", "map_id": "none", "name": "CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604956", "map_id": "none", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604938", "map_id": "none", "name": "GRK2:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09639", "map_id": "Q09639", "name": "phospho-grk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604868", "map_id": "none", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604866", "map_id": "none", "name": "cAMP:PKA regulatory subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604860", "map_id": "P21137", "name": "kin-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604923", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10651257", "map_id": "none", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10651245", "map_id": "none", "name": "Homologues of p-S422-SGK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10651255", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604443", "map_id": "none", "name": "PDPK1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9UA62", "map_id": "Q9UA62", "name": "PDPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021022", "map_id": "WBGene00021022", "name": "PDPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655489", "map_id": "none", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655483", "map_id": "Q09564", "name": "phospho-phlp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009647", "map_id": "WBGene00009647", "name": "phospho-phlp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655487", "map_id": "Q09564", "name": "phospho-phlp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10645807", "map_id": "none", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645791", "map_id": "none", "name": "HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3AUJ9", "map_id": "A0A0K3AUJ9", "name": "prdx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F09E5.15c", "map_id": "F09E5.15c", "name": "prdx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645799", "map_id": "Q9N4D6", "name": "sesn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022279", "map_id": "WBGene00022279", "name": "sesn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645805", "map_id": "none", "name": "SESN1,2,3:HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N4D6", "map_id": "Q9N4D6", "name": "sesn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598469", "map_id": "none", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598466", "map_id": "none", "name": "G6PD dimer and tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27464", "map_id": "Q27464", "name": "gspd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007108", "map_id": "WBGene00007108", "name": "gspd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599754", "map_id": "none", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599751", "map_id": "none", "name": "GSR-2:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93379", "map_id": "Q93379", "name": "gsr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008117", "map_id": "WBGene00008117", "name": "gsr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651416", "map_id": "none", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651410", "map_id": "Q9XTF3", "name": "mbk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003150", "map_id": "WBGene00003150", "name": "phospho-mbk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651414", "map_id": "Q9XTF3", "name": "phospho-mbk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10639605", "map_id": "none", "name": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636065", "map_id": "none", "name": "GPX2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93204", "map_id": "Q93204", "name": "gpx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007516", "map_id": "WBGene00007516", "name": "gpx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655691", "map_id": "none", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655683", "map_id": "none", "name": "Homologues of SFN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10655685", "map_id": "none", "name": "SFN Dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10645811", "map_id": "none", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617093", "map_id": "none", "name": "p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A1T5HUK9", "map_id": "A0A1T5HUK9", "name": "aakg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013732", "map_id": "WBGene00013732", "name": "aakg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUY2", "map_id": "Q9XUY2", "name": "aakb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010115", "map_id": "WBGene00010115", "name": "aakb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45894", "map_id": "P45894", "name": "phospho-aak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019801", "map_id": "WBGene00019801", "name": "phospho-aak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02168", "map_id": "O02168", "name": "aakg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020633", "map_id": "WBGene00020633", "name": "aakg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N501", "map_id": "Q9N501", "name": "aakg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021527", "map_id": "WBGene00021527", "name": "aakg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZQ4", "map_id": "Q95ZQ4", "name": "phospho-aak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020142", "map_id": "WBGene00020142", "name": "phospho-aak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAH7", "map_id": "Q9NAH7", "name": "aakb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012928", "map_id": "WBGene00012928", "name": "aakb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645809", "map_id": "none", "name": "SESN1,2,3:p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10655536", "map_id": "none", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10655527", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00019778", "map_id": "WBGene00019778", "name": "RABGGTA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655532", "map_id": "P41992", "name": "ggtb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00015099", "map_id": "WBGene00015099", "name": "ggtb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655534", "map_id": "none", "name": "RGGT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TYY0", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41992", "map_id": "P41992", "name": "ggtb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662505", "map_id": "none", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662497", "map_id": "Q20619", "name": "efl-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009899", "map_id": "WBGene00009899", "name": "efl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662503", "map_id": "none", "name": "E2F8 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20619", "map_id": "Q20619", "name": "efl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662495", "map_id": "none", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662491", "map_id": "Q20619", "name": "efl-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10662493", "map_id": "none", "name": "E2F7 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10655485", "map_id": "none", "name": "ATM phosphorylates PIDD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10655480", "map_id": "Q09564", "name": "phlp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10598826", "map_id": "none", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113522", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598823", "map_id": "none", "name": "GLS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "U4PRW7", "map_id": "U4PRW7", "name": "glna-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007480", "map_id": "WBGene00007480", "name": "glna-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93650", "map_id": "Q93650", "name": "glna-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009271", "map_id": "WBGene00009271", "name": "glna-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19013", "map_id": "Q19013", "name": "glna-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008435", "map_id": "WBGene00008435", "name": "glna-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660349", "map_id": "none", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10625955", "map_id": "Q9N492", "name": "pinn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022448", "map_id": "WBGene00022448", "name": "pinn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660342", "map_id": "none", "name": "p-S326-PIP4K2B dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660347", "map_id": "none", "name": "p-S326-PIP4K2B dimers:PIN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N492", "map_id": "Q9N492", "name": "pinn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651355", "map_id": "none", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651335", "map_id": "none", "name": "Elongation Complex at DNA Repair Genes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17869", "map_id": "O17869", "name": "ccnk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009650", "map_id": "WBGene00009650", "name": "ccnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21338", "map_id": "Q21338", "name": "phospho-spt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005015", "map_id": "WBGene00005015", "name": "phospho-spt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QG8", "map_id": "Q95QG8", "name": "fcp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009479", "map_id": "WBGene00009479", "name": "fcp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECR7", "map_id": "G5ECR7", "name": "elb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001235", "map_id": "WBGene00001235", "name": "elb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17245", "map_id": "O17245", "name": "mnat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018769", "map_id": "WBGene00018769", "name": "mnat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFV5", "map_id": "G5EFV5", "name": "cdk-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000408", "map_id": "WBGene00000408", "name": "cdk-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZ93", "map_id": "Q9TZ93", "name": "spt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005014", "map_id": "WBGene00005014", "name": "spt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09413", "map_id": "Q09413", "name": "tceb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010990", "map_id": "WBGene00010990", "name": "tceb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4U0", "map_id": "Q9N4U0", "name": "cyh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021714", "map_id": "WBGene00021714", "name": "cyh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N554", "map_id": "Q9N554", "name": "ell-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021281", "map_id": "WBGene00021281", "name": "ell-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKS1", "map_id": "Q9BKS1", "name": "elc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001236", "map_id": "WBGene00001236", "name": "elc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34425", "map_id": "P34425", "name": "cit-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000507", "map_id": "WBGene00000507", "name": "cit-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TVL3", "map_id": "Q9TVL3", "name": "cdk-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000410", "map_id": "WBGene00000410", "name": "cdk-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5R9", "map_id": "Q9N5R9", "name": "spt-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018849", "map_id": "WBGene00018849", "name": "spt-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52652", "map_id": "P52652", "name": "TCEA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012000", "map_id": "WBGene00012000", "name": "TCEA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41848", "map_id": "P41848", "name": "hmg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001974", "map_id": "WBGene00001974", "name": "hmg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651264", "map_id": "none", "name": "CCNK:CDK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P46551", "map_id": "P46551", "name": "cdk-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007135", "map_id": "WBGene00007135", "name": "cdk-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651337", "map_id": "none", "name": "CCNK:CDK12:Elongation Complex at DNA Repair Genes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10655689", "map_id": "none", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655677", "map_id": "none", "name": "CCNB1:CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10655687", "map_id": "none", "name": "SFN Dimer:CCNB1:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10645794", "map_id": "none", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639622", "map_id": "none", "name": "PRDX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598605", "map_id": "none", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598600", "map_id": "none", "name": "GPI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K707", "map_id": "Q7K707", "name": "gpi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013597", "map_id": "WBGene00013597", "name": "gpi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651266", "map_id": "none", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605098", "map_id": "O17869", "name": "ccnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10651262", "map_id": "P46551", "name": "cdk-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10660345", "map_id": "none", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660331", "map_id": "none", "name": "PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622470", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10651272", "map_id": "none", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651268", "map_id": "P46551", "name": "cdk-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10651270", "map_id": "none", "name": "CCNK:CDK13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10662501", "map_id": "none", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662499", "map_id": "none", "name": "E2F7:E2F8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639631", "map_id": "none", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639628", "map_id": "none", "name": "PRDX1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10651247", "map_id": "none", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637490", "map_id": "none", "name": "Homologues of SGK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611000", "map_id": "none", "name": "TORC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NA80", "map_id": "Q9NA80", "name": "sinh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013261", "map_id": "WBGene00013261", "name": "sinh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91040", "map_id": "P91040", "name": "mlst-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015697", "map_id": "WBGene00015697", "name": "mlst-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFN2", "map_id": "G5EFN2", "name": "rict-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009245", "map_id": "WBGene00009245", "name": "rict-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q95", "map_id": "Q95Q95", "name": "let-363", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002583", "map_id": "WBGene00002583", "name": "let-363", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655545", "map_id": "none", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655541", "map_id": "Q9BKQ5", "name": "rep-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022051", "map_id": "WBGene00022051", "name": "rep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655543", "map_id": "none", "name": "RGGT:CHM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BKQ5", "map_id": "Q9BKQ5", "name": "rep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617109", "map_id": "none", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606957", "map_id": "none", "name": "Active mTORC1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "P34443", "map_id": "P34443", "name": "rheb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010038", "map_id": "WBGene00010038", "name": "rheb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q68TI8", "map_id": "Q68TI8", "name": "daf-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000911", "map_id": "WBGene00000911", "name": "daf-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGB3", "map_id": "G5EGB3", "name": "ragc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012497", "map_id": "WBGene00012497", "name": "ragc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17268", "map_id": "O17268", "name": "lmtr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020101", "map_id": "WBGene00020101", "name": "lmtr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19425", "map_id": "Q19425", "name": "SLC38A9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008774", "map_id": "WBGene00008774", "name": "SLC38A9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617106", "map_id": "none", "name": "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10651353", "map_id": "none", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651350", "map_id": "none", "name": "CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10655741", "map_id": "none", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605168", "map_id": "none", "name": "FACT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10655737", "map_id": "none", "name": "Casein kinase II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10655739", "map_id": "none", "name": "CK2:FACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614736", "map_id": "none", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_265479", "map_id": "LigandDisplayForward?ligandId=6816", "name": "ezetimibe", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10614732", "map_id": "none", "name": "Homologues of NPC1L1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19127", "map_id": "Q19127", "name": "ncr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003561", "map_id": "WBGene00003561", "name": "ncr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34389", "map_id": "P34389", "name": "ncr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003562", "map_id": "WBGene00003562", "name": "ncr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614734", "map_id": "none", "name": "NPC1L1:ezetimibe", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10661657", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661653", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10661655", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661663", "map_id": "none", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628559", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10661617", "map_id": "none", "name": "Homologues of p-Y693-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617891", "map_id": "none", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_390627", "map_id": "none", "name": "ADR, NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_374935", "map_id": "CHEBI:18357", "name": "NAd", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209794", "map_id": "CHEBI:28918", "name": "ADR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616740", "map_id": "none", "name": "ADRA2A,B,C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19084", "map_id": "Q19084", "name": "tyra-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017157", "map_id": "WBGene00017157", "name": "tyra-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02213", "map_id": "O02213", "name": "ser-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004777", "map_id": "WBGene00004777", "name": "ser-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616742", "map_id": "none", "name": "ADRA2A,B,C:ADR,NAd", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617885", "map_id": "none", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616519", "map_id": "G5EBX8", "name": "ser-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008890", "map_id": "WBGene00008890", "name": "ser-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616523", "map_id": "none", "name": "ADRA1A,B,D:ADR,NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBX8", "map_id": "G5EBX8", "name": "ser-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617883", "map_id": "none", "name": "\u00ce\u00b11-agonists:ADRA1A,B,D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=483", "map_id": "LigandDisplayForward?ligandId=483", "name": "LigandDisplayForward?ligandId=483", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=485", "map_id": "LigandDisplayForward?ligandId=485", "name": "LigandDisplayForward?ligandId=485", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=124", "map_id": "LigandDisplayForward?ligandId=124", "name": "LigandDisplayForward?ligandId=124", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=480", "map_id": "LigandDisplayForward?ligandId=480", "name": "LigandDisplayForward?ligandId=480", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3469", "map_id": "LigandDisplayForward?ligandId=3469", "name": "LigandDisplayForward?ligandId=3469", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=481", "map_id": "LigandDisplayForward?ligandId=481", "name": "LigandDisplayForward?ligandId=481", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617881", "map_id": "none", "name": "\u00ce\u00b11-antagonists:ADRA1A,B,D", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7302", "map_id": "LigandDisplayForward?ligandId=7302", "name": "LigandDisplayForward?ligandId=7302", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=503", "map_id": "LigandDisplayForward?ligandId=503", "name": "LigandDisplayForward?ligandId=503", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7170", "map_id": "LigandDisplayForward?ligandId=7170", "name": "LigandDisplayForward?ligandId=7170", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656795", "map_id": "none", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610899", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XTG7", "map_id": "Q9XTG7", "name": "phospho-akt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000103", "map_id": "WBGene00000103", "name": "phospho-akt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17941", "map_id": "Q17941", "name": "phospho-akt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000102", "map_id": "WBGene00000102", "name": "phospho-akt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617854", "map_id": "none", "name": "Homologues of AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10656790", "map_id": "none", "name": "PP2A-B56-beta,gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18178", "map_id": "O18178", "name": "pptr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012348", "map_id": "WBGene00012348", "name": "pptr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10636518", "map_id": "none", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636515", "map_id": "none", "name": "Activator:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F3NWW5", "map_id": "F3NWW5", "name": "phospho-kin-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002195", "map_id": "WBGene00002195", "name": "phospho-kin-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZU7", "map_id": "H2KZU7", "name": "phospho-svh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020504", "map_id": "WBGene00020504", "name": "phospho-svh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21868", "map_id": "Q21868", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021745", "map_id": "WBGene00021745", "name": "phospho-Autophosphorylated FLT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21046", "map_id": "Q21046", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18163", "map_id": "Q18163", "name": "phospho-ddr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016104", "map_id": "WBGene00016104", "name": "phospho-ddr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10656", "map_id": "Q10656", "name": "phospho-egl-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001184", "map_id": "WBGene00001184", "name": "phospho-egl-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q45FX5", "map_id": "Q45FX5", "name": "vav-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006887", "map_id": "WBGene00006887", "name": "vav-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFK8", "map_id": "G5EFK8", "name": "EGF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008779", "map_id": "WBGene00008779", "name": "EGF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED65", "map_id": "G5ED65", "name": "phospho-ver-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006894", "map_id": "WBGene00006894", "name": "phospho-ver-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17955", "map_id": "O17955", "name": "phospho-kin-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002211", "map_id": "WBGene00002211", "name": "phospho-kin-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1I6CMA1", "map_id": "A0A1I6CMA1", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N413", "map_id": "Q9N413", "name": "pvf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004249", "map_id": "WBGene00004249", "name": "pvf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23136", "map_id": "Q23136", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21867", "map_id": "Q21867", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17833", "map_id": "Q17833", "name": "phospho-old-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003862", "map_id": "WBGene00003862", "name": "phospho-old-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23677", "map_id": "Q23677", "name": "phospho-old-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003863", "map_id": "WBGene00003863", "name": "phospho-old-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4T2", "map_id": "Q9N4T2", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19238", "map_id": "Q19238", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94125", "map_id": "Q94125", "name": "age-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000090", "map_id": "WBGene00000090", "name": "age-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZK1", "map_id": "Q95ZK1", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C3B4", "map_id": "A0A2C9C3B4", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18008", "map_id": "O18008", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633249", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633030", "map_id": "O01759", "name": "ppk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004087", "map_id": "WBGene00004087", "name": "ppk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633061", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633058", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10658313", "map_id": "none", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610622", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658301", "map_id": "none", "name": "p-Y307-PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658310", "map_id": "none", "name": "Activated SRC,LCK,EGFR,INSR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10642713", "map_id": "none", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612004", "map_id": "none", "name": "AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21227", "map_id": "Q21227", "name": "apr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000156", "map_id": "WBGene00000156", "name": "apr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09595", "map_id": "Q09595", "name": "GSK3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010991", "map_id": "WBGene00010991", "name": "GSK3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93372", "map_id": "Q93372", "name": "GSK3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21204", "map_id": "Q21204", "name": "CSNK1A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010555", "map_id": "WBGene00010555", "name": "CSNK1A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFL7", "map_id": "G5EFL7", "name": "CSNK1A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62090", "map_id": "O62090", "name": "pry-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004202", "map_id": "WBGene00004202", "name": "pry-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17828", "map_id": "O17828", "name": "prde-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008995", "map_id": "WBGene00008995", "name": "prde-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2Q9", "map_id": "Q9U2Q9", "name": "gsk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001746", "map_id": "WBGene00001746", "name": "gsk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42168", "map_id": "P42168", "name": "kin-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002202", "map_id": "WBGene00002202", "name": "kin-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q3LRZ3", "map_id": "Q3LRZ3", "name": "axl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010497", "map_id": "WBGene00010497", "name": "axl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610661", "map_id": "none", "name": "p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661437", "map_id": "none", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661433", "map_id": "none", "name": "'canonical' WNT target genes:TCF/LEF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q10666", "map_id": "Q10666", "name": "pop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004077", "map_id": "WBGene00004077", "name": "pop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639314", "map_id": "none", "name": "TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02482", "map_id": "O02482", "name": "unc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006773", "map_id": "WBGene00006773", "name": "unc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661435", "map_id": "none", "name": "'canonical' WNT target gene:TCF/LEF:TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10635829", "map_id": "none", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613633", "map_id": "none", "name": "BTRC:CUL1:RBX1:SKP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17389", "map_id": "Q17389", "name": "cul-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000836", "map_id": "WBGene00000836", "name": "cul-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECU1", "map_id": "G5ECU1", "name": "skr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004807", "map_id": "WBGene00004807", "name": "skr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610677", "map_id": "none", "name": "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44326", "map_id": "O44326", "name": "hmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635827", "map_id": "none", "name": "RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610705", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610692", "map_id": "none", "name": "p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610672", "map_id": "none", "name": "p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635835", "map_id": "none", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635831", "map_id": "none", "name": "ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10635833", "map_id": "none", "name": "p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635837", "map_id": "none", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10641384", "map_id": "none", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639298", "map_id": "O02482", "name": "unc-37", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10610714", "map_id": "none", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610709", "map_id": "none", "name": "CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610699", "map_id": "none", "name": "p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610684", "map_id": "none", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610702", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610688", "map_id": "none", "name": "p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610711", "map_id": "none", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610707", "map_id": "O44326", "name": "hmp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610695", "map_id": "none", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10643089", "map_id": "none", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638387", "map_id": "Q20595", "name": "ctbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006424", "map_id": "WBGene00006424", "name": "ctbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639287", "map_id": "Q10666", "name": "pop-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10643087", "map_id": "none", "name": "TCF7L2/TCF7L1:CTBPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20595", "map_id": "Q20595", "name": "ctbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610682", "map_id": "none", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10654727", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10654724", "map_id": "none", "name": "GNPDA1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ2", "map_id": "Q9XVJ2", "name": "GNPDA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011399", "map_id": "WBGene00011399", "name": "GNPDA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598546", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598543", "map_id": "none", "name": "GAPDH tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P04970", "map_id": "P04970", "name": "gpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001683", "map_id": "WBGene00001683", "name": "gpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17331", "map_id": "P17331", "name": "gpd-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001686", "map_id": "WBGene00001686", "name": "gpd-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17329", "map_id": "P17329", "name": "gpd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001684", "map_id": "WBGene00001684", "name": "gpd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17330", "map_id": "P17330", "name": "gpd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001685", "map_id": "WBGene00001685", "name": "gpd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599692", "map_id": "none", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30485", "map_id": "CHEBI:58289", "name": "2PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29492", "map_id": "CHEBI:58702", "name": "PEP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598654", "map_id": "none", "name": "enolase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27527", "map_id": "Q27527", "name": "enol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011884", "map_id": "WBGene00011884", "name": "enol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599874", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598638", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91427", "map_id": "P91427", "name": "pgk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020185", "map_id": "WBGene00020185", "name": "pgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649423", "map_id": "none", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10649420", "map_id": "none", "name": "ADPGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q86S40", "map_id": "Q86S40", "name": "ADPGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016810", "map_id": "WBGene00016810", "name": "ADPGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598593", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598590", "map_id": "none", "name": "PFK tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TZL8", "map_id": "Q9TZL8", "name": "pfk-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022199", "map_id": "WBGene00022199", "name": "pfk-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27483", "map_id": "Q27483", "name": "pfk-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008230", "map_id": "WBGene00008230", "name": "pfk-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598507", "map_id": "none", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598504", "map_id": "none", "name": "glucokinase and hexokinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N4A5", "map_id": "Q9N4A5", "name": "hxk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022306", "map_id": "WBGene00022306", "name": "hxk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU15", "map_id": "Q9XU15", "name": "hxk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010416", "map_id": "WBGene00010416", "name": "hxk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19440", "map_id": "Q19440", "name": "hxk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008780", "map_id": "WBGene00008780", "name": "hxk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599870", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599867", "map_id": "none", "name": "PFKFB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21122", "map_id": "Q21122", "name": "phospho-pfkb-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019295", "map_id": "WBGene00019295", "name": "phospho-pfkb-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N590", "map_id": "Q9N590", "name": "pfkb-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022456", "map_id": "WBGene00022456", "name": "pfkb-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662663", "map_id": "none", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955759", "map_id": "CHEBI:18148", "name": "G1,6BP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598402", "map_id": "none", "name": "PGM2L1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45934", "map_id": "O45934", "name": "PGM2L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012803", "map_id": "WBGene00012803", "name": "PGM2L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599719", "map_id": "none", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599716", "map_id": "none", "name": "pyruvate kinase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B7WNA0", "map_id": "B7WNA0", "name": "pyk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009126", "map_id": "WBGene00009126", "name": "pyk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23539", "map_id": "Q23539", "name": "pyk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014001", "map_id": "WBGene00014001", "name": "pyk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10598391", "map_id": "none", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598388", "map_id": "none", "name": "phosphoPFKFB1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598556", "map_id": "none", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598553", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10657", "map_id": "Q10657", "name": "tpi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006601", "map_id": "WBGene00006601", "name": "tpi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607710", "map_id": "none", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607708", "map_id": "none", "name": "Homologues of GCK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598486", "map_id": "none", "name": "Homologues of GCK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599571", "map_id": "none", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599566", "map_id": "none", "name": "aldolase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54216", "map_id": "P54216", "name": "aldo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011474", "map_id": "WBGene00011474", "name": "aldo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46563", "map_id": "P46563", "name": "aldo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017166", "map_id": "WBGene00017166", "name": "aldo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625184", "map_id": "none", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10625181", "map_id": "none", "name": "ALDH5A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02266", "map_id": "O02266", "name": "alh-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000113", "map_id": "WBGene00000113", "name": "alh-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625666", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_916850", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10625663", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21217", "map_id": "Q21217", "name": "gta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001794", "map_id": "WBGene00001794", "name": "gta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641688", "map_id": "none", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641545", "map_id": "none", "name": "Me2K10-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27490", "map_id": "Q27490", "name": "his-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001944", "map_id": "WBGene00001944", "name": "his-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K7ZUH9", "map_id": "K7ZUH9", "name": "his-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001914", "map_id": "WBGene00001914", "name": "his-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641673", "map_id": "none", "name": "Me3K10-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641685", "map_id": "none", "name": "SUV39H1, SUV39H2, SETDB1, SETDB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34544", "map_id": "P34544", "name": "met-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019883", "map_id": "WBGene00019883", "name": "met-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18221", "map_id": "Q18221", "name": "set-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004782", "map_id": "WBGene00004782", "name": "set-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642433", "map_id": "none", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642398", "map_id": "none", "name": "MeR12-histone H2A, Histone H2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P09588", "map_id": "P09588", "name": "his-65", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001877", "map_id": "WBGene00001877", "name": "his-65", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27485", "map_id": "Q27485", "name": "his-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001909", "map_id": "WBGene00001909", "name": "his-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23429", "map_id": "Q23429", "name": "htas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014240", "map_id": "WBGene00014240", "name": "htas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642431", "map_id": "none", "name": "Me2aR12-histone H2A, MeR12-histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638603", "map_id": "Q9U2X0", "name": "prmt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013766", "map_id": "WBGene00013766", "name": "prmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646433", "map_id": "none", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10642265", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001875", "map_id": "WBGene00001875", "name": "his-56", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602463", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29478", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641569", "map_id": "Q9GYI4", "name": "psr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004205", "map_id": "WBGene00004205", "name": "psr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646024", "map_id": "none", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646006", "map_id": "none", "name": "Me2K80-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646022", "map_id": "none", "name": "Me3K80-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646011", "map_id": "Q6AW06", "name": "dot-1.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021474", "map_id": "WBGene00021474", "name": "dot-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638598", "map_id": "none", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638586", "map_id": "none", "name": "MeK5-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638588", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638595", "map_id": "none", "name": "KDM1A,KDM1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21988", "map_id": "Q21988", "name": "amx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000137", "map_id": "WBGene00000137", "name": "amx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXU5", "map_id": "Q9XXU5", "name": "amx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000138", "map_id": "WBGene00000138", "name": "amx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642756", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641580", "map_id": "none", "name": "Me2K5-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10642749", "map_id": "none", "name": "Me3K5-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10642753", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17963", "map_id": "Q17963", "name": "wdr-5.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006474", "map_id": "WBGene00006474", "name": "wdr-5.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09309", "map_id": "Q09309", "name": "rbbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017683", "map_id": "WBGene00017683", "name": "rbbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGI1", "map_id": "G5EGI1", "name": "set-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011729", "map_id": "WBGene00011729", "name": "set-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09415", "map_id": "Q09415", "name": "set-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011068", "map_id": "WBGene00011068", "name": "set-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10661", "map_id": "Q10661", "name": "dpy-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001088", "map_id": "WBGene00001088", "name": "dpy-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFZ3", "map_id": "G5EFZ3", "name": "ash-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012458", "map_id": "WBGene00012458", "name": "ash-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642358", "map_id": "none", "name": "Me2aR3-histone H3, MeR3-histone H3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10642562", "map_id": "none", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642554", "map_id": "none", "name": "Me2sR3-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10642559", "map_id": "Q9XW42", "name": "prmt-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012298", "map_id": "WBGene00012298", "name": "prmt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641713", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641526", "map_id": "none", "name": "MeK37-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641710", "map_id": "none", "name": "Homologues of SMYD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XV44", "map_id": "Q9XV44", "name": "set-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009370", "map_id": "WBGene00009370", "name": "set-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4F7", "map_id": "Q8I4F7", "name": "set-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044070", "map_id": "WBGene00044070", "name": "set-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23084", "map_id": "Q23084", "name": "set-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022499", "map_id": "WBGene00022499", "name": "set-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646014", "map_id": "none", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645998", "map_id": "none", "name": "MeK80-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641594", "map_id": "none", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641585", "map_id": "Q23541", "name": "rbr-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004319", "map_id": "WBGene00004319", "name": "rbr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640230", "map_id": "none", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640182", "map_id": "none", "name": "Acetylated core histone octamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27894", "map_id": "Q27894", "name": "his-54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001878", "map_id": "WBGene00001878", "name": "his-54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27876", "map_id": "Q27876", "name": "his-58", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001922", "map_id": "WBGene00001922", "name": "his-58", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27484", "map_id": "Q27484", "name": "his-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001915", "map_id": "WBGene00001915", "name": "his-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P62784", "map_id": "P62784", "name": "his-56", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04255", "map_id": "P04255", "name": "his-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001885", "map_id": "WBGene00001885", "name": "his-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640188", "map_id": "none", "name": "Core histone octamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10640227", "map_id": "none", "name": "HDAC1:2-containing complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XVG8", "map_id": "Q9XVG8", "name": "hmg-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012209", "map_id": "WBGene00012209", "name": "hmg-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17695", "map_id": "O17695", "name": "hda-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001834", "map_id": "WBGene00001834", "name": "hda-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECR1", "map_id": "G5ECR1", "name": "mbd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023409", "map_id": "WBGene00023409", "name": "mbd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90917", "map_id": "P90917", "name": "rba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004312", "map_id": "WBGene00004312", "name": "rba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90916", "map_id": "P90916", "name": "lin-53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003036", "map_id": "WBGene00003036", "name": "lin-53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61907", "map_id": "O61907", "name": "lin-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003025", "map_id": "WBGene00003025", "name": "lin-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18919", "map_id": "Q18919", "name": "spr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005006", "map_id": "WBGene00005006", "name": "spr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED89", "map_id": "G5ED89", "name": "dcp-66", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000938", "map_id": "WBGene00000938", "name": "dcp-66", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22516", "map_id": "Q22516", "name": "chd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000482", "map_id": "WBGene00000482", "name": "chd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y41", "map_id": "Q95Y41", "name": "rcor-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022278", "map_id": "WBGene00022278", "name": "rcor-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641550", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641547", "map_id": "none", "name": "MeK10-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641538", "map_id": "Q9U297", "name": "jmjd-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012982", "map_id": "WBGene00012982", "name": "jmjd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639479", "map_id": "none", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639441", "map_id": "none", "name": "Histone H2B, H4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113560", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639476", "map_id": "none", "name": "AcK-replicative histone H2B, H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_2485002", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10646440", "map_id": "none", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646438", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10646427", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646028", "map_id": "none", "name": "Me3K28-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641602", "map_id": "none", "name": "Me2K28-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641624", "map_id": "none", "name": "KDM6A,KDM6B,KDM6C,KDM7A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20367", "map_id": "Q20367", "name": "jmjd-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005013", "map_id": "WBGene00005013", "name": "jmjd-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QK3", "map_id": "Q95QK3", "name": "jmjd-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017571", "map_id": "WBGene00017571", "name": "jmjd-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19760", "map_id": "Q19760", "name": "jmjd-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009089", "map_id": "WBGene00009089", "name": "jmjd-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYI0", "map_id": "Q9GYI0", "name": "phospho-jmjd-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017920", "map_id": "WBGene00017920", "name": "phospho-jmjd-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642588", "map_id": "none", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614312", "map_id": "none", "name": "Homologues of RBBP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10642586", "map_id": "none", "name": "RBBP7:Replicative histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641564", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641561", "map_id": "none", "name": "KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646429", "map_id": "none", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642356", "map_id": "none", "name": "Me2aR3-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638866", "map_id": "none", "name": "MeR3-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639435", "map_id": "none", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639388", "map_id": "K7ZUH9", "name": "his-40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639394", "map_id": "K7ZUH9", "name": "his-40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639432", "map_id": "none", "name": "KAT7:ING4,5 dimers:MEAF6:PHF17,(15,16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A3QMD7", "map_id": "A3QMD7", "name": "lsy-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020287", "map_id": "WBGene00020287", "name": "lsy-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZX6", "map_id": "Q95ZX6", "name": "mys-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007914", "map_id": "WBGene00007914", "name": "mys-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3F6", "map_id": "Q9N3F6", "name": "phf-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021810", "map_id": "WBGene00021810", "name": "phf-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQC3", "map_id": "Q8WQC3", "name": "MEAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015001", "map_id": "WBGene00015001", "name": "MEAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641627", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641610", "map_id": "none", "name": "MeK28-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646425", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10641572", "map_id": "none", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10645990", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645980", "map_id": "none", "name": "Me2K37-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646415", "map_id": "none", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10645875", "map_id": "none", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645859", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645865", "map_id": "none", "name": "MeK10-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645870", "map_id": "Q22024", "name": "egl-43", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001207", "map_id": "WBGene00001207", "name": "egl-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642584", "map_id": "none", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641985", "map_id": "Q17963", "name": "wdr-5.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10642582", "map_id": "none", "name": "WDR5:Me2sR3-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10645934", "map_id": "none", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10641543", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641540", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95Q98", "map_id": "Q95Q98", "name": "jhdm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020821", "map_id": "WBGene00020821", "name": "jhdm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U297", "map_id": "Q9U297", "name": "jmjd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646413", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10646026", "map_id": "none", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10646431", "map_id": "none", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10640361", "map_id": "none", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640358", "map_id": "none", "name": "Homologues of HDAC10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20296", "map_id": "Q20296", "name": "hda-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018319", "map_id": "WBGene00018319", "name": "hda-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4I9", "map_id": "Q8I4I9", "name": "hda-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009663", "map_id": "WBGene00009663", "name": "hda-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646411", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10646435", "map_id": "none", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642363", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10644106", "map_id": "none", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636181", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636492", "map_id": "Q22795", "name": "set-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004781", "map_id": "WBGene00004781", "name": "set-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644109", "map_id": "none", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636190", "map_id": "Q9GYI0", "name": "jmjd-1.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10641995", "map_id": "none", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641992", "map_id": "none", "name": "Core MLL complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10640129", "map_id": "none", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639929", "map_id": "none", "name": "Histone H2A, H2B, H3, H4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10640126", "map_id": "none", "name": "AcK-histone H2A, H2B, H3, H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628901", "map_id": "P34545", "name": "cbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000366", "map_id": "WBGene00000366", "name": "cbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642268", "map_id": "none", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10639915", "map_id": "none", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639905", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639912", "map_id": "none", "name": "HAT1:RBBP7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21484", "map_id": "Q21484", "name": "hat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044069", "map_id": "WBGene00044069", "name": "hat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617848", "map_id": "none", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_353123", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193514", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390305", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10610430", "map_id": "Q9BIA9", "name": "ACOT8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00015887", "map_id": "WBGene00015887", "name": "ACOT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617805", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617802", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q20992", "map_id": "Q20992", "name": "acox-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019060", "map_id": "WBGene00019060", "name": "acox-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617812", "map_id": "none", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389982", "map_id": "CHEBI:63914", "name": "3-hydroxypristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389996", "map_id": "CHEBI:15371", "name": "3-ketopristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10610284", "map_id": "none", "name": "HSD17B4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q19058", "map_id": "Q19058", "name": "maoc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017123", "map_id": "WBGene00017123", "name": "maoc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617810", "map_id": "none", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10617814", "map_id": "none", "name": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390002", "map_id": "CHEBI:15495", "name": "4,8,12-trimethyltridecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192314", "map_id": "CHEBI:15539", "name": "propionyl CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10610329", "map_id": "G5EDP2", "name": "daf-22", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00013284", "map_id": "WBGene00013284", "name": "daf-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617795", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10610321", "map_id": "none", "name": "ACOX2:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O62138", "map_id": "O62138", "name": "acox-1.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008566", "map_id": "WBGene00008566", "name": "acox-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93839", "map_id": "Q93839", "name": "acox-1.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010336", "map_id": "WBGene00010336", "name": "acox-1.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62139", "map_id": "O62139", "name": "acox-1.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008567", "map_id": "WBGene00008567", "name": "acox-1.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34355", "map_id": "P34355", "name": "acox-1.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008167", "map_id": "WBGene00008167", "name": "acox-1.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62140", "map_id": "O62140", "name": "acox-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008564", "map_id": "WBGene00008564", "name": "acox-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62137", "map_id": "O62137", "name": "acox-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008565", "map_id": "WBGene00008565", "name": "acox-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617807", "map_id": "none", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389569", "map_id": "CHEBI:51341", "name": "(2R) Pristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10610255", "map_id": "Q18122", "name": "AMACR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00016034", "map_id": "WBGene00016034", "name": "AMACR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617835", "map_id": "none", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390294", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390271", "map_id": "CHEBI:63856", "name": "4,8-dimethylnonanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390290", "map_id": "CHEBI:63874", "name": "4,8-dimethylnonanoylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617832", "map_id": "A0A486WVT5", "name": "CROT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00011850", "map_id": "WBGene00011850", "name": "CROT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617845", "map_id": "none", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390287", "map_id": "CHEBI:15960", "name": "ACAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617840", "map_id": "Q17499", "name": "CRAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00007175", "map_id": "WBGene00007175", "name": "CRAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617843", "map_id": "none", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390274", "map_id": "CHEBI:28867", "name": "Propionylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610040", "map_id": "none", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191296", "map_id": "CHEBI:17436", "name": "MVA5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610037", "map_id": "none", "name": "MVK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q65XX9", "map_id": "Q65XX9", "name": "mvk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021534", "map_id": "WBGene00021534", "name": "mvk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610751", "map_id": "none", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196420", "map_id": "CHEBI:17737", "name": "DESMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10610748", "map_id": "O17397", "name": "DHCR24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00018718", "map_id": "WBGene00018718", "name": "DHCR24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610020", "map_id": "none", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191293", "map_id": "CHEBI:57286", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191374", "map_id": "CHEBI:43074", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610017", "map_id": "P54871", "name": "hmgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017769", "map_id": "WBGene00017769", "name": "hmgs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661829", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10661826", "map_id": "Q22461", "name": "PLPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020486", "map_id": "WBGene00020486", "name": "PLPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642772", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10642769", "map_id": "Q21765", "name": "arv-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00011040", "map_id": "WBGene00011040", "name": "arv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610030", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610027", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19207", "map_id": "Q19207", "name": "hmgr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017268", "map_id": "WBGene00017268", "name": "hmgr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610012", "map_id": "none", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610009", "map_id": "none", "name": "holo-FDPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O62336", "map_id": "O62336", "name": "fdps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011058", "map_id": "WBGene00011058", "name": "fdps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610050", "map_id": "none", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610047", "map_id": "none", "name": "IDI1 or 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFQ1", "map_id": "G5EFQ1", "name": "idi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019460", "map_id": "WBGene00019460", "name": "idi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666341", "map_id": "none", "name": "DHCR24 reduces LAN to 24,25-dhLAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194634", "map_id": "CHEBI:16521", "name": "LAN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1130708", "map_id": "CHEBI:28113", "name": "24,25-dhLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10666337", "map_id": "Q9XX00", "name": "sbp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00004735", "map_id": "WBGene00004735", "name": "sbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610068", "map_id": "none", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191403", "map_id": "CHEBI:15899", "name": "MVA5PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610065", "map_id": "I2HAD9", "name": "PMVK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009335", "map_id": "WBGene00009335", "name": "PMVK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610060", "map_id": "none", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610057", "map_id": "none", "name": "MVD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U294", "map_id": "Q9U294", "name": "MVD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012984", "map_id": "WBGene00012984", "name": "MVD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655790", "map_id": "none", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194691", "map_id": "CHEBI:18252", "name": "ZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6807048", "map_id": "CHEBI:16608", "name": "ZYMSTNL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10610015", "map_id": "none", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655788", "map_id": "none", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807057", "map_id": "CHEBI:17759", "name": "7-dehydroCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10610740", "map_id": "G5ED82", "name": "dhcr-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007126", "map_id": "WBGene00007126", "name": "dhcr-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610743", "map_id": "none", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_195655", "map_id": "CHEBI:27910", "name": "7dhDESOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10638184", "map_id": "none", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638084", "map_id": "none", "name": "SUMO1:UBA2:SAE1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P55853", "map_id": "P55853", "name": "smo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004888", "map_id": "WBGene00004888", "name": "smo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17820", "map_id": "Q17820", "name": "aos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000142", "map_id": "WBGene00000142", "name": "aos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAN1", "map_id": "Q9NAN1", "name": "uba-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006700", "map_id": "WBGene00006700", "name": "uba-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638173", "map_id": "Q95017", "name": "ubc-9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006706", "map_id": "WBGene00006706", "name": "ubc-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638181", "map_id": "none", "name": "SUMO1:C93-UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95017", "map_id": "Q95017", "name": "ubc-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638069", "map_id": "none", "name": "UBA2:SAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10655749", "map_id": "none", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614867", "map_id": "Q09390", "name": "hmg-1.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001972", "map_id": "WBGene00001972", "name": "hmg-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655694", "map_id": "Q09390", "name": "hmg-1.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10655698", "map_id": "none", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_181015", "map_id": "CHEBI:28640", "name": "Lipoteichoic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10655696", "map_id": "none", "name": "HC23,45-HMGB1:LTA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q09390", "map_id": "Q09390", "name": "hmg-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659495", "map_id": "none", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2186967", "map_id": "CHEBI:60156", "name": "oxidized phospholipids", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10607100", "map_id": "none", "name": "Homologues of LBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18869", "map_id": "Q18869", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020563", "map_id": "WBGene00020563", "name": "LBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17738", "map_id": "Q17738", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2Z8", "map_id": "H9G2Z8", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20380", "map_id": "Q20380", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93796", "map_id": "Q93796", "name": "nrf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003812", "map_id": "WBGene00003812", "name": "nrf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23365", "map_id": "Q23365", "name": "BPI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022627", "map_id": "WBGene00022627", "name": "BPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8WFJ7", "map_id": "A8WFJ7", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17654", "map_id": "Q17654", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10011", "map_id": "Q10011", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17768", "map_id": "O17768", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659493", "map_id": "none", "name": "LBP:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10655702", "map_id": "none", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10655700", "map_id": "none", "name": "HC23,45-HMGB1:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10607106", "map_id": "none", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10607102", "map_id": "none", "name": "LBP:bacterial LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10607104", "map_id": "Q23365", "name": "BPI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10661651", "map_id": "none", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661647", "map_id": "none", "name": "p-STAT1:p-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10661649", "map_id": "none", "name": "p-Y693-STAT4:p-Y701-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661665", "map_id": "none", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625310", "map_id": "none", "name": "Homologues of p-Y701-STAT1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628565", "map_id": "none", "name": "p-Y701-STAT1: p-Y-705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661629", "map_id": "none", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661619", "map_id": "none", "name": "p-Y693-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10661627", "map_id": "none", "name": "Y963-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661661", "map_id": "none", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661659", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628577", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611863", "map_id": "none", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611857", "map_id": "Q9U9K0", "name": "add-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000072", "map_id": "WBGene00000072", "name": "add-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611861", "map_id": "Q9U9K0", "name": "add-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611859", "map_id": "Q9U9K0", "name": "add-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605337", "map_id": "none", "name": "Caspase-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P42573", "map_id": "P42573", "name": "ced-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000417", "map_id": "WBGene00000417", "name": "ced-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611874", "map_id": "none", "name": "Caspase-mediated cleavage of gelsolin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611868", "map_id": "Q21253", "name": "gsnl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010593", "map_id": "WBGene00010593", "name": "gsnl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611870", "map_id": "Q21253", "name": "gsnl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611872", "map_id": "Q21253", "name": "gsnl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612305", "map_id": "none", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612299", "map_id": "Q21408", "name": "spc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004951", "map_id": "WBGene00004951", "name": "spc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612303", "map_id": "Q21408", "name": "spc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612301", "map_id": "Q21408", "name": "spc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612294", "map_id": "none", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612290", "map_id": "Q9XUT0", "name": "dbn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612292", "map_id": "Q9XUT0", "name": "dbn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636129", "map_id": "none", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160866", "map_id": "none", "name": "(HA)2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_2162224", "map_id": "CHEBI:64024", "name": "GlcA-\u00ce\u00b21,3-GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1678868", "map_id": "CHEBI:4178", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2162223", "map_id": "none", "name": "GlcNAc-GlcA-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10633421", "map_id": "none", "name": "GUSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q95Q32", "map_id": "Q95Q32", "name": "GUSB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013693", "map_id": "WBGene00013693", "name": "GUSB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665108", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10632601", "map_id": "none", "name": "bHEXB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q22492", "map_id": "Q22492", "name": "hex-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020509", "map_id": "WBGene00020509", "name": "hex-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636011", "map_id": "none", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160864", "map_id": "none", "name": "(HA)50", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10633435", "map_id": "G5ECE8", "name": "chhy-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00011923", "map_id": "WBGene00011923", "name": "chhy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636127", "map_id": "none", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10636032", "map_id": "none", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10636029", "map_id": "none", "name": "HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECE8", "map_id": "G5ECE8", "name": "chhy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK1", "map_id": "G5EBK1", "name": "pbo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003943", "map_id": "WBGene00003943", "name": "pbo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L039", "map_id": "H2L039", "name": "nhx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003734", "map_id": "WBGene00003734", "name": "nhx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDH8", "map_id": "G5EDH8", "name": "nhx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003729", "map_id": "WBGene00003729", "name": "nhx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35449", "map_id": "P35449", "name": "nhx-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003736", "map_id": "WBGene00003736", "name": "nhx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23643", "map_id": "Q23643", "name": "phospho-chpf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014109", "map_id": "WBGene00014109", "name": "phospho-chpf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T5S1", "map_id": "Q8T5S1", "name": "nhx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003730", "map_id": "WBGene00003730", "name": "nhx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDU2", "map_id": "G5EDU2", "name": "nhx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003732", "map_id": "WBGene00003732", "name": "nhx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16452", "map_id": "O16452", "name": "nhx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003731", "map_id": "WBGene00003731", "name": "nhx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2160894", "map_id": "none", "name": "(HA)50", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636125", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10632577", "map_id": "none", "name": "HEXA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10609537", "map_id": "none", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609448", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6A590", "map_id": "Q6A590", "name": "FBXL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020884", "map_id": "WBGene00020884", "name": "FBXL3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17868", "map_id": "Q17868", "name": "cks-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001051", "map_id": "WBGene00001051", "name": "cks-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598143", "map_id": "none", "name": "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10609440", "map_id": "none", "name": "CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10609431", "map_id": "none", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609423", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10609428", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598270", "map_id": "none", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598260", "map_id": "none", "name": "Processive complex:Okazaki fragments:Remaining Flap", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02334", "map_id": "O02334", "name": "pri-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004181", "map_id": "WBGene00004181", "name": "pri-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34471", "map_id": "P34471", "name": "pri-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004180", "map_id": "WBGene00004180", "name": "pri-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7IVS4", "map_id": "C7IVS4", "name": "pola-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012936", "map_id": "WBGene00012936", "name": "pola-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21625", "map_id": "Q21625", "name": "div-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001002", "map_id": "WBGene00001002", "name": "div-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598262", "map_id": "none", "name": "Processive complex:nicked DNA from adjacent Okazaki fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598267", "map_id": "Q9N3T2", "name": "crn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10609442", "map_id": "none", "name": "Association of Cks1 with SCF(Skp2) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609433", "map_id": "none", "name": "CUL1:SKP1:SKP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10609438", "map_id": "Q17868", "name": "cks-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10598156", "map_id": "none", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598154", "map_id": "none", "name": "ubiquitinated Cdc6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91155", "map_id": "P91155", "name": "cdc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000382", "map_id": "WBGene00000382", "name": "cdc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10609606", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609602", "map_id": "none", "name": "FZR1,p-S795-RB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDT1", "map_id": "G5EDT1", "name": "lin-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003020", "map_id": "WBGene00003020", "name": "lin-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09649", "map_id": "Q09649", "name": "fzr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609604", "map_id": "none", "name": "p-FZR1,p-RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597866", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10609421", "map_id": "none", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10609419", "map_id": "G5EEJ2", "name": "cki-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598146", "map_id": "none", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597697", "map_id": "P91155", "name": "cdc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10598123", "map_id": "P91155", "name": "phospho-cdc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10597902", "map_id": "none", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597841", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012650", "map_id": "WBGene00012650", "name": "phospho-orc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597877", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597899", "map_id": "none", "name": "SCF (SKP2) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598204", "map_id": "none", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598198", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598202", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex:PCNA ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608079", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607961", "map_id": "none", "name": "CCNA:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10609540", "map_id": "none", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609444", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598158", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597820", "map_id": "none", "name": "MCM2-7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21902", "map_id": "Q21902", "name": "mcm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003157", "map_id": "WBGene00003157", "name": "mcm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVR7", "map_id": "Q9XVR7", "name": "mcm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003155", "map_id": "WBGene00003155", "name": "mcm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XQ8", "map_id": "Q95XQ8", "name": "mcm-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003156", "map_id": "WBGene00003156", "name": "mcm-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16297", "map_id": "O16297", "name": "mcm-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003159", "map_id": "WBGene00003159", "name": "mcm-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXI9", "map_id": "Q9XXI9", "name": "mcm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003154", "map_id": "WBGene00003154", "name": "mcm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34647", "map_id": "P34647", "name": "mcm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003158", "map_id": "WBGene00003158", "name": "mcm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597811", "map_id": "Q9XVR7", "name": "mcm-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597804", "map_id": "none", "name": "MCM4:MCM6:MCM7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597787", "map_id": "Q9XXI9", "name": "mcm-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597816", "map_id": "Q21902", "name": "mcm-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10598150", "map_id": "none", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598148", "map_id": "P91155", "name": "phospho-cdc-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636953", "map_id": "none", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636933", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O01789", "map_id": "O01789", "name": "him-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001860", "map_id": "WBGene00001860", "name": "him-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19325", "map_id": "Q19325", "name": "phospho-scc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004737", "map_id": "WBGene00004737", "name": "phospho-scc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19555", "map_id": "Q19555", "name": "phospho-scc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004738", "map_id": "WBGene00004738", "name": "phospho-scc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2FDA8", "map_id": "B2FDA8", "name": "smc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004873", "map_id": "WBGene00004873", "name": "smc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0H5", "map_id": "H2L0H5", "name": "wapl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019953", "map_id": "WBGene00019953", "name": "wapl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC05", "map_id": "G5EC05", "name": "evl-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001352", "map_id": "WBGene00001352", "name": "evl-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636941", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636950", "map_id": "none", "name": "ESCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19206", "map_id": "Q19206", "name": "ESCO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017269", "map_id": "WBGene00017269", "name": "ESCO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597749", "map_id": "none", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9757634", "map_id": "CHEBI:61557", "name": "NTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10597744", "map_id": "none", "name": "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597740", "map_id": "none", "name": "DNA polymerase epsilon", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597746", "map_id": "none", "name": "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598258", "map_id": "none", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598249", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598254", "map_id": "Q9U3F2", "name": "dna-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001016", "map_id": "WBGene00001016", "name": "dna-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598256", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3F2", "map_id": "Q9U3F2", "name": "dna-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610968", "map_id": "none", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610965", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610909", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597906", "map_id": "none", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597904", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636990", "map_id": "none", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636986", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Centromere", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636988", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Centromere", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598189", "map_id": "none", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598113", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598187", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598200", "map_id": "none", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598196", "map_id": "none", "name": "PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608402", "map_id": "none", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608388", "map_id": "O62193", "name": "psf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009287", "map_id": "WBGene00009287", "name": "psf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608383", "map_id": "Q22019", "name": "psf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00011275", "map_id": "WBGene00011275", "name": "psf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608393", "map_id": "Q9BL54", "name": "psf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022043", "map_id": "WBGene00022043", "name": "psf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608398", "map_id": "Q9U2W9", "name": "sld-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013768", "map_id": "WBGene00013768", "name": "sld-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608400", "map_id": "none", "name": "GINS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U2W9", "map_id": "Q9U2W9", "name": "sld-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62193", "map_id": "O62193", "name": "psf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL54", "map_id": "Q9BL54", "name": "psf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22019", "map_id": "Q22019", "name": "psf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598232", "map_id": "none", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598225", "map_id": "none", "name": "Processive complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598229", "map_id": "none", "name": "Processive complex:Okazaki fragment complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10598223", "map_id": "none", "name": "DNA Polymerase delta tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607963", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598280", "map_id": "O61847", "name": "cdk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607594", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10609608", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601816", "map_id": "none", "name": "CAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598278", "map_id": "none", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68452", "map_id": "none", "name": "Okazaki fragment", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_69172", "map_id": "none", "name": "ligated okazaki fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10609598", "map_id": "none", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609595", "map_id": "none", "name": "Cyclin A:Cdk2:phospho-p27/p21 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598116", "map_id": "none", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30185", "map_id": "CHEBI:61481", "name": "dCTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30187", "map_id": "CHEBI:37568", "name": "dTTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29604", "map_id": "CHEBI:61404", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29892", "map_id": "CHEBI:61429", "name": "dGTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10597721", "map_id": "none", "name": "DNA polymerase alpha:primase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597869", "map_id": "none", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597822", "map_id": "none", "name": "pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XX17", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX16", "map_id": "Q9XX16", "name": "orc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012651", "map_id": "WBGene00012651", "name": "orc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23249", "map_id": "Q23249", "name": "orc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013857", "map_id": "WBGene00013857", "name": "orc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21037", "map_id": "Q21037", "name": "orc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003882", "map_id": "WBGene00003882", "name": "orc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86S68", "map_id": "Q86S68", "name": "cdt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000413", "map_id": "WBGene00000413", "name": "cdt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597845", "map_id": "none", "name": "pre-replicative complex (Orc1-minus)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10609446", "map_id": "none", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10598227", "map_id": "none", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10598236", "map_id": "none", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598234", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598111", "map_id": "none", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10607697", "map_id": "none", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607678", "map_id": "none", "name": "G alpha-olf:GTP:Adenylate cyclase (active) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "V6CLB7", "map_id": "V6CLB7", "name": "gpa-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020997", "map_id": "WBGene00020997", "name": "gpa-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KPV0", "map_id": "Q7KPV0", "name": "gsa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001745", "map_id": "WBGene00001745", "name": "gsa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607692", "map_id": "none", "name": "G alpha-olf:GDP:Adenylate cyclase (active) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607687", "map_id": "none", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607685", "map_id": "none", "name": "(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BIG5", "map_id": "Q9BIG5", "name": "gpa-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001666", "map_id": "WBGene00001666", "name": "gpa-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_111349", "map_id": "CHEBI:17552", "name": "GDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9N2V6", "map_id": "Q9N2V6", "name": "gpa-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001678", "map_id": "WBGene00001678", "name": "gpa-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607683", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607669", "map_id": "none", "name": "G alpha-olf:GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608410", "map_id": "none", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608404", "map_id": "Q22000", "name": "pde-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020114", "map_id": "WBGene00020114", "name": "pde-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608407", "map_id": "Q22000", "name": "phospho-pde-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607674", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607667", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607671", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607694", "map_id": "none", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10607216", "map_id": "none", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607202", "map_id": "none", "name": "Opioid:MOR:G protein-GDP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P17343", "map_id": "P17343", "name": "gpb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001679", "map_id": "WBGene00001679", "name": "gpb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1DQQ4", "map_id": "A0A3B1DQQ4", "name": "npr-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006864", "map_id": "WBGene00006864", "name": "npr-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09502", "map_id": "Q09502", "name": "npr-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008065", "map_id": "WBGene00008065", "name": "npr-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECT6", "map_id": "G5ECT6", "name": "gpc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001682", "map_id": "WBGene00001682", "name": "gpc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGU1", "map_id": "G5EGU1", "name": "egl-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001196", "map_id": "WBGene00001196", "name": "egl-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C3A4", "map_id": "A0A2C9C3A4", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018089", "map_id": "WBGene00018089", "name": "SSTR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34311", "map_id": "P34311", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ0", "map_id": "Q9XVQ0", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20841", "map_id": "Q20841", "name": "npr-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018886", "map_id": "WBGene00018886", "name": "npr-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AXD3", "map_id": "A0A0K3AXD3", "name": "npr-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011372", "map_id": "WBGene00011372", "name": "npr-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G358", "map_id": "H9G358", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20636", "map_id": "Q20636", "name": "gpb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001680", "map_id": "WBGene00001680", "name": "gpb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23033", "map_id": "Q23033", "name": "npr-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020086", "map_id": "WBGene00020086", "name": "npr-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54406", "map_id": "P54406", "name": "gpc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001681", "map_id": "WBGene00001681", "name": "gpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607214", "map_id": "none", "name": "Opioid:MOR:G-protein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607219", "map_id": "none", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605068", "map_id": "none", "name": "Opioid:MOR:G protein-GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10604837", "map_id": "G5EGU1", "name": "egl-30", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10604848", "map_id": "none", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10604845", "map_id": "none", "name": "Activated PLC beta 1/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBH0", "map_id": "G5EBH0", "name": "egl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001177", "map_id": "WBGene00001177", "name": "egl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607198", "map_id": "none", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10604843", "map_id": "none", "name": "G protein alpha:GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10604969", "map_id": "none", "name": "G-protein alpha:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665289", "map_id": "none", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10604971", "map_id": "none", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604832", "map_id": "G5EBH0", "name": "egl-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607700", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10604931", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604928", "map_id": "Q22000", "name": "pde-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607690", "map_id": "none", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10607221", "map_id": "none", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10605064", "map_id": "none", "name": "G-protein beta-gamma complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607200", "map_id": "none", "name": "G protein-GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607676", "map_id": "none", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607665", "map_id": "none", "name": "G-protein alpha (i):GTP:Adenylate cyclase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607647", "map_id": "none", "name": "G alpha-olf:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607681", "map_id": "none", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10628746", "map_id": "none", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10628743", "map_id": "none", "name": "V-ATPase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q22494", "map_id": "Q22494", "name": "vha-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020507", "map_id": "WBGene00020507", "name": "vha-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HLB3", "map_id": "C0HLB3", "name": "vha-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006911", "map_id": "WBGene00006911", "name": "vha-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW92", "map_id": "Q9XW92", "name": "vha-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013025", "map_id": "WBGene00013025", "name": "vha-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23680", "map_id": "Q23680", "name": "vha-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006918", "map_id": "WBGene00006918", "name": "vha-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEK9", "map_id": "G5EEK9", "name": "vha-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006914", "map_id": "WBGene00006914", "name": "vha-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXU9", "map_id": "Q9XXU9", "name": "vha-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006920", "map_id": "WBGene00006920", "name": "vha-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30628", "map_id": "P30628", "name": "unc-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006768", "map_id": "WBGene00006768", "name": "unc-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGP4", "map_id": "G5EGP4", "name": "vha-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006915", "map_id": "WBGene00006915", "name": "vha-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YD5", "map_id": "Q95YD5", "name": "vha-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016258", "map_id": "WBGene00016258", "name": "vha-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2MZD0", "map_id": "B2MZD0", "name": "vha-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006916", "map_id": "WBGene00006916", "name": "vha-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34462", "map_id": "P34462", "name": "vha-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010130", "map_id": "WBGene00010130", "name": "vha-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HLB4", "map_id": "C0HLB4", "name": "vha-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006912", "map_id": "WBGene00006912", "name": "vha-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91303", "map_id": "P91303", "name": "vha-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006919", "map_id": "WBGene00006919", "name": "vha-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95X44", "map_id": "Q95X44", "name": "vha-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006917", "map_id": "WBGene00006917", "name": "vha-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19626", "map_id": "Q19626", "name": "vha-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006921", "map_id": "WBGene00006921", "name": "vha-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20591", "map_id": "Q20591", "name": "vha-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009882", "map_id": "WBGene00009882", "name": "vha-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB8", "map_id": "G5EDB8", "name": "vha-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006913", "map_id": "WBGene00006913", "name": "vha-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650440", "map_id": "none", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10650430", "map_id": "none", "name": "MPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "Q23490", "map_id": "Q23490", "name": "mlt-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022743", "map_id": "WBGene00022743", "name": "mlt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG78", "map_id": "G5EG78", "name": "pxn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004257", "map_id": "WBGene00004257", "name": "pxn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91060", "map_id": "P91060", "name": "skpo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015841", "map_id": "WBGene00015841", "name": "skpo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ENI8", "map_id": "Q1ENI8", "name": "pxn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004256", "map_id": "WBGene00004256", "name": "pxn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ53", "map_id": "H2KZ53", "name": "skpo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017968", "map_id": "WBGene00017968", "name": "skpo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:55376", "map_id": "CHEBI:55376", "name": "CHEBI:55376", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20616", "map_id": "Q20616", "name": "skpo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009897", "map_id": "WBGene00009897", "name": "skpo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650432", "map_id": "none", "name": "MPO:ferriheme:bacterial cell surface", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10650435", "map_id": "none", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_6788973", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222719", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6789150", "map_id": "CHEBI:24757", "name": "HOCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222475", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10658173", "map_id": "none", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855492", "map_id": "CHEBI:18022", "name": "SCN(-)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855489", "map_id": "CHEBI:133907", "name": "OSCN-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10658170", "map_id": "none", "name": "LPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10650438", "map_id": "none", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "reaction_10660758", "map_id": "none", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_6789221", "map_id": "CHEBI:16301", "name": "nitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_8933637", "map_id": "CHEBI:33101", "name": "NO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10621247", "map_id": "none", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_445829", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_445832", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_10621244", "map_id": "none", "name": "Homologues of SLC11A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "true" }, { "id": "Q21434", "map_id": "Q21434", "name": "smf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004876", "map_id": "WBGene00004876", "name": "smf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21433", "map_id": "Q21433", "name": "smf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004877", "map_id": "WBGene00004877", "name": "smf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XG8", "map_id": "Q95XG8", "name": "smf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004878", "map_id": "WBGene00004878", "name": "smf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664718", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647011", "map_id": "none", "name": "Active FLT3:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665968", "map_id": "none", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611187", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000912", "map_id": "WBGene00000912", "name": "daf-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664881", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665966", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611173", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611163", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10662906", "map_id": "none", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10662895", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q05062", "map_id": "Q05062", "name": "cdc-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000390", "map_id": "WBGene00000390", "name": "cdc-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21430", "map_id": "Q21430", "name": "pix-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010776", "map_id": "WBGene00010776", "name": "pix-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17850", "map_id": "Q17850", "name": "pak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003911", "map_id": "WBGene00003911", "name": "pak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62422", "map_id": "O62422", "name": "crp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012532", "map_id": "WBGene00012532", "name": "crp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636260", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636257", "map_id": "none", "name": "GRB2:SOS1:HB-EGF:p-6Y-EGFR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624986", "map_id": "none", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616840", "map_id": "none", "name": "Heterotrimeric G-protein Gi (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10655747", "map_id": "none", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6805204", "map_id": "CHEBI:18344", "name": "Kynurenic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10655743", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00016570", "map_id": "WBGene00016570", "name": "gnrr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655745", "map_id": "none", "name": "GPR35:Kynurenic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KZ99", "map_id": "H2KZ99", "name": "gnrr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624999", "map_id": "none", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618849", "map_id": "none", "name": "G-protein alpha (12/13):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19572", "map_id": "Q19572", "name": "gpa-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001674", "map_id": "WBGene00001674", "name": "gpa-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605451", "map_id": "none", "name": "G-protein G12/G13 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624982", "map_id": "none", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616838", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O18014", "map_id": "O18014", "name": "npr-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011381", "map_id": "WBGene00011381", "name": "npr-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_380873", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "P91439", "map_id": "P91439", "name": "npr-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020319", "map_id": "WBGene00020319", "name": "npr-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U7D5", "map_id": "Q9U7D5", "name": "gar-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001519", "map_id": "WBGene00001519", "name": "gar-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09638", "map_id": "Q09638", "name": "npr-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012084", "map_id": "WBGene00012084", "name": "npr-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXT2", "map_id": "Q1ZXT2", "name": "ador-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011878", "map_id": "WBGene00011878", "name": "ador-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0Q3", "map_id": "H2L0Q3", "name": "gbb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021528", "map_id": "WBGene00021528", "name": "gbb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19295", "map_id": "Q19295", "name": "npr-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017338", "map_id": "WBGene00017338", "name": "npr-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15650", "map_id": "CHEBI:15650", "name": "CHEBI:15650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_266074", "map_id": "CHEBI:28666", "name": "LTD4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_390899", "map_id": "CHEBI:18295", "name": "Hist", "type": "complex_component", "sub_type": 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"gtr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6RYS9", "map_id": "Q6RYS9", "name": "dop-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020506", "map_id": "WBGene00020506", "name": "dop-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18775", "map_id": "Q18775", "name": "dop-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016872", "map_id": "WBGene00016872", "name": "dop-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1IMB8", "map_id": "A1IMB8", "name": "mgl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021152", "map_id": "WBGene00021152", "name": "mgl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_419339", "map_id": "CHEBI:16796", "name": "MLT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "G5ECB2", "map_id": "G5ECB2", "name": "gbb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022675", "map_id": "WBGene00022675", "name": "gbb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114523", "map_id": "CHEBI:28790", "name": "5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "Q09630", "map_id": "Q09630", "name": "mgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003232", "map_id": "WBGene00003232", "name": "mgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP61", "map_id": "Q7JP61", "name": "octr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006411", "map_id": "WBGene00006411", "name": "octr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_266013", "map_id": "CHEBI:16978", "name": "LTC4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "G5EGH0", "map_id": "G5EGH0", "name": "ser-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004779", "map_id": "WBGene00004779", "name": "ser-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62189", "map_id": "O62189", "name": "npr-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009278", "map_id": "WBGene00009278", "name": "npr-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76667", "map_id": "O76667", "name": "npr-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019183", "map_id": "WBGene00019183", "name": "npr-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616842", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618991", "map_id": "none", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616818", "map_id": "none", "name": "Melatonin receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616820", "map_id": "none", "name": "Melatonin receptors:melatonin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666012", "map_id": "none", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666009", "map_id": "Q8I0P7", "name": "pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008443", "map_id": "WBGene00008443", "name": "phospho-pde-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617905", "map_id": "none", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616408", "map_id": "none", "name": "HTR4,6,7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22895", "map_id": "Q22895", "name": "ser-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004780", "map_id": "WBGene00004780", "name": "ser-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86ME6", "map_id": "Q86ME6", "name": "dop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001052", "map_id": "WBGene00001052", "name": "dop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616410", "map_id": "none", "name": "HTR4,6,7:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617893", "map_id": "none", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10636278", "map_id": "none", "name": "Homologues of MMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q23227", "map_id": "Q23227", "name": "zmp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012364", "map_id": "WBGene00012364", "name": "zmp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17913", "map_id": "O17913", "name": "zmp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010423", "map_id": "WBGene00010423", "name": "zmp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBU3", "map_id": "G5EBU3", "name": "zmp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016283", "map_id": "WBGene00016283", "name": "zmp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3ARD1", "map_id": "A0A0K3ARD1", "name": "MMP3(100-477)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00194737", "map_id": "WBGene00194737", "name": "MMP3(100-477)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21182", "map_id": "Q21182", "name": "MMP3(100-477)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62390", "map_id": "O62390", "name": "MMP3(100-477)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44836", "map_id": "O44836", "name": "zmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019212", "map_id": "WBGene00019212", "name": "zmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECC4", "map_id": "G5ECC4", "name": "zmp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020646", "map_id": "WBGene00020646", "name": "zmp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630578", "map_id": "none", "name": "Homologues of MMP3(100-477)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10624788", "map_id": "none", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616656", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "O44536", "map_id": "O44536", "name": "gnrr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019224", "map_id": "WBGene00019224", "name": "gnrr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28364", "map_id": "CHEBI:28364", "name": "CHEBI:28364", "type": "complex_component", "sub_type": 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"CHEBI:27432", "name": "ALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8934421", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "G5EG10", "map_id": "G5EG10", "name": "mgl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003233", "map_id": "WBGene00003233", "name": "mgl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45601", "map_id": "O45601", "name": "tag-89", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006459", "map_id": "WBGene00006459", "name": "tag-89", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53487", "map_id": "CHEBI:53487", "name": "CHEBI:53487", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16196", "map_id": "CHEBI:16196", "name": "CHEBI:16196", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93518", "map_id": "Q93518", "name": "thrombin heavy chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U320", "map_id": "Q9U320", "name": "daf-38", "type": "complex_component", "sub_type": 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"sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:28661", "map_id": "CHEBI:28661", "name": "CHEBI:28661", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53486", "map_id": "CHEBI:53486", "name": "CHEBI:53486", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53488", "map_id": "CHEBI:53488", "name": "CHEBI:53488", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19399", "map_id": "Q19399", "name": "gnrr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008736", "map_id": "WBGene00008736", "name": "gnrr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28716", "map_id": "CHEBI:28716", "name": "CHEBI:28716", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27997", "map_id": "CHEBI:27997", "name": "CHEBI:27997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17899", "map_id": "O17899", "name": "pcdr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010329", "map_id": "WBGene00010329", "name": "pcdr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17470", "map_id": "O17470", "name": "ser-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004776", "map_id": "WBGene00004776", "name": "ser-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_266056", "map_id": "CHEBI:15647", "name": "LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "P91096", "map_id": "P91096", "name": "dop-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016037", "map_id": "WBGene00016037", "name": "dop-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605486", "map_id": "none", "name": "Heterotrimeric G-protein Gq/11 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616658", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10651371", "map_id": "none", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6797635", "map_id": "CHEBI:17815", "name": "1,2-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10651368", "map_id": "Q22250", "name": "plpr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00011524", "map_id": "WBGene00011524", "name": "plpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621741", "map_id": "none", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444761", "map_id": "CHEBI:37397", "name": "CHS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10621737", "map_id": "none", "name": "EGF-7TMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECX0", "map_id": "G5ECX0", "name": "lat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002252", "map_id": "WBGene00002252", "name": "lat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19930", "map_id": "Q19930", "name": "mth-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017947", "map_id": "WBGene00017947", "name": "mth-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621739", "map_id": "none", "name": "EGF-7TMs:CHS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624997", "map_id": "none", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624992", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624988", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618959", "map_id": "none", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616603", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_417888", "map_id": "CHEBI:58223", "name": "UDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10616605", "map_id": "none", "name": "GPR17:UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663247", "map_id": "none", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663242", "map_id": "none", "name": "G alpha (q):GDP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18563", "map_id": "Q18563", "name": "rgs-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004349", "map_id": "WBGene00004349", "name": "rgs-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23376", "map_id": "Q23376", "name": "rgs-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004352", "map_id": "WBGene00004352", "name": "rgs-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECK9", "map_id": "G5ECK9", "name": "rgs-8.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004351", "map_id": "WBGene00004351", "name": "rgs-8.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45524", "map_id": "O45524", "name": "rgs-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004354", "map_id": "WBGene00004354", "name": "rgs-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49808", "map_id": "P49808", "name": "rgs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004345", "map_id": "WBGene00004345", "name": "rgs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQC0", "map_id": "Q8WQC0", "name": "rgs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004350", "map_id": "WBGene00004350", "name": "rgs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45523", "map_id": "O45523", "name": "rgs-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004353", "map_id": "WBGene00004353", "name": "rgs-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663229", "map_id": "none", "name": "RGS1,2,3,4,5,13,16,17,18,19,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605484", "map_id": "none", "name": "G-protein alpha (q/11):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618506", "map_id": "none", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10604943", "map_id": "P90980", "name": "pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624961", "map_id": "none", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616660", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624953", "map_id": "none", "name": "GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q95YD7", "map_id": "Q95YD7", "name": "trhr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016265", "map_id": "WBGene00016265", "name": "trhr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62403", "map_id": "O62403", "name": "npr-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013782", "map_id": "WBGene00013782", "name": "npr-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17239", "map_id": "O17239", "name": "nmur-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019616", "map_id": "WBGene00019616", "name": "nmur-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44731", "map_id": "O44731", "name": 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"type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDI0", "map_id": "G5EDI0", "name": "dcar-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007395", "map_id": "WBGene00007395", "name": "dcar-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AYF5", "map_id": "A0A0K3AYF5", "name": "npr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C16D6.2b", "map_id": "C16D6.2b", "name": "npr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18130", "map_id": "Q18130", "name": "NTSR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016044", "map_id": "WBGene00016044", "name": "NTSR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18701", "map_id": "Q18701", "name": "nmur-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016747", "map_id": "WBGene00016747", "name": "nmur-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03566", "map_id": "Q03566", "name": "tkr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006576", "map_id": "WBGene00006576", "name": "tkr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624959", "map_id": "none", "name": "Ligands of GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:6498", "map_id": "CHEBI:6498", "name": "CHEBI:6498", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30772", "map_id": "CHEBI:30772", "name": "CHEBI:30772", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265287", "map_id": "CHEBI:15551", "name": "PGE2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8869214", "map_id": "CHEBI:52450", "name": "PAF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_427486", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "CHEBI:17120", "map_id": "CHEBI:17120", "name": "CHEBI:17120", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:50122", "map_id": "CHEBI:50122", "name": "CHEBI:50122", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30212", "map_id": "CHEBI:30212", "name": "CHEBI:30212", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:42504", "map_id": "CHEBI:42504", "name": "CHEBI:42504", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879535", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29444", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": 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"complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000149", "map_id": "WBGene00000149", "name": "apl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:31011", "map_id": "CHEBI:31011", "name": "CHEBI:31011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618957", "map_id": "none", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10616766", "map_id": "none", "name": "ADORA1,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616768", "map_id": "none", "name": "ADORA1,3:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618961", "map_id": "none", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616447", "map_id": "none", "name": "ADORA2A,B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616449", "map_id": "none", "name": "ADORA2A,B:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665053", "map_id": "none", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665050", "map_id": "Q8I0P7", "name": "pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605432", "map_id": "none", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605406", "map_id": "none", "name": "RHOA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605408", "map_id": "none", "name": "RHOA:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605429", "map_id": "none", "name": "G13-activated p115-RhoGEF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFE1", "map_id": "G5EFE1", "name": "rhgf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006468", "map_id": "WBGene00006468", "name": "rhgf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0P5", "map_id": "H2L0P5", "name": "prhg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022391", "map_id": "WBGene00022391", "name": "prhg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615432", "map_id": "none", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615428", "map_id": "none", "name": "GRM1-8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615430", "map_id": "none", "name": "GRM1-8:L-Glu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617972", "map_id": "none", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616631", "map_id": "none", "name": "LTB4R,LTB4R2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_416436", "map_id": "CHEBI:15647", "name": "LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10616633", "map_id": "none", "name": "LTB4R,LTB4R2:LTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664924", "map_id": "none", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615597", "map_id": "none", "name": "Homologues of AGTR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9615246", "map_id": "none", "name": "ARBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=587", "map_id": "LigandDisplayForward?ligandId=587", "name": "LigandDisplayForward?ligandId=587", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=592", "map_id": "LigandDisplayForward?ligandId=592", "name": "LigandDisplayForward?ligandId=592", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=588", "map_id": "LigandDisplayForward?ligandId=588", "name": "LigandDisplayForward?ligandId=588", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=589", "map_id": "LigandDisplayForward?ligandId=589", "name": "LigandDisplayForward?ligandId=589", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6896", "map_id": "LigandDisplayForward?ligandId=6896", "name": "LigandDisplayForward?ligandId=6896", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=591", "map_id": "LigandDisplayForward?ligandId=591", "name": "LigandDisplayForward?ligandId=591", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3937", "map_id": "LigandDisplayForward?ligandId=3937", "name": "LigandDisplayForward?ligandId=3937", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=590", "map_id": "LigandDisplayForward?ligandId=590", "name": "LigandDisplayForward?ligandId=590", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664922", "map_id": "none", "name": "ARBs:AGTR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617895", "map_id": "none", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616718", "map_id": "none", "name": "DRD3,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616720", "map_id": "none", "name": "DRD3,4:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618573", "map_id": "none", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618571", "map_id": "none", "name": "G-protein alpha (q):GRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605434", "map_id": "none", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605415", "map_id": "none", "name": "G-protein alpha (13):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605427", "map_id": "none", "name": "Homologues of ARHGEF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10616856", "map_id": "none", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10616846", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616852", "map_id": "Q19955", "name": "ags-3", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000092", "map_id": "WBGene00000092", "name": "ags-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617897", "map_id": "none", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616704", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616706", "map_id": "none", "name": "HRH4:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616667", "map_id": "none", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616664", "map_id": "none", "name": "LTC4:CyslTR1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662889", "map_id": "none", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662884", "map_id": "none", "name": "G protein alpha (i):GTP:p-Y416-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607663", "map_id": "none", "name": "G alpha (i): GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10662882", "map_id": "G5EE56", "name": "phospho-src-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617899", "map_id": "none", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616392", "map_id": "O45732", "name": "dop-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00011382", "map_id": "WBGene00011382", "name": "dop-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616394", "map_id": "none", "name": "HRH2:histamine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45732", "map_id": "O45732", "name": "dop-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624984", "map_id": "none", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10618928", "map_id": "none", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618926", "map_id": "none", "name": "RGS proteins active for G alpha (q)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624980", "map_id": "none", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10621705", "map_id": "none", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616641", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616645", "map_id": "none", "name": "pH sensing receptors:H+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625140", "map_id": "none", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621723", "map_id": "none", "name": "Homologues of CD97", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10625136", "map_id": "none", "name": "Homologues of CD55", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18849", "map_id": "Q18849", "name": "CR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008314", "map_id": "WBGene00008314", "name": "CR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22328", "map_id": "Q22328", "name": "lev-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002976", "map_id": "WBGene00002976", "name": "lev-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625138", "map_id": "none", "name": "CD55:CD97", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617970", "map_id": "none", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_416372", "map_id": "none", "name": "LTC4,LTD4,LTE4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10616770", "map_id": "none", "name": "GPR17:Cysteinyl leukotrienes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624978", "map_id": "none", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624969", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624975", "map_id": "none", "name": "ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618852", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618112", "map_id": "none", "name": "G-protein alpha (12/13):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617962", "map_id": "none", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616424", "map_id": "none", "name": "Thyrostimulin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q21013", "map_id": "Q21013", "name": "flr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001466", "map_id": "WBGene00001466", "name": "flr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A7DT38", "map_id": "A7DT38", "name": "gpb5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020722", "map_id": "WBGene00020722", "name": "gpb5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616415", "map_id": "L8EC40", "name": "fshr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008239", "map_id": "WBGene00008239", "name": "fshr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616426", "map_id": "none", "name": "TSHR:Thyrotropin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "L8EC40", "map_id": "L8EC40", "name": "fshr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618729", "map_id": "none", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616552", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616554", "map_id": "none", "name": "P2RY9:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618847", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618844", "map_id": "none", "name": "cAMP PDEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22000", "map_id": "Q22000", "name": "pde-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2V9", "map_id": "Q9N2V9", "name": "pde-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022389", "map_id": "WBGene00022389", "name": "pde-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91119", "map_id": "P91119", "name": "pde-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016328", "map_id": "WBGene00016328", "name": "pde-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617901", "map_id": "none", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616700", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616702", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665554", "map_id": "none", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10665550", "map_id": "Q6RYS9", "name": "dop-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10665552", "map_id": "none", "name": "DRD2:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617889", "map_id": "none", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616508", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616514", "map_id": "none", "name": "CHRM1,3,5:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618733", "map_id": "none", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616548", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616550", "map_id": "none", "name": "P2RY5:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662897", "map_id": "none", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608724", "map_id": "none", "name": "CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613387", "map_id": "Q21430", "name": "pix-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10617723", "map_id": "Q17850", "name": "pak-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617974", "map_id": "none", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616599", "map_id": "none", "name": "Homologues of CYSLTR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616601", "map_id": "none", "name": "CYSLTR2:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617903", "map_id": "none", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616544", "map_id": "none", "name": "HTR2A-C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616546", "map_id": "none", "name": "HTR2A-C:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665773", "map_id": "none", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616585", "map_id": "none", "name": "Homologues of CYSLTR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9684615", "map_id": "none", "name": "CYSLTR1 antagonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=3381", "map_id": "LigandDisplayForward?ligandId=3381", "name": "LigandDisplayForward?ligandId=3381", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3329", "map_id": "LigandDisplayForward?ligandId=3329", "name": "LigandDisplayForward?ligandId=3329", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3327", "map_id": "LigandDisplayForward?ligandId=3327", "name": "LigandDisplayForward?ligandId=3327", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3322", "map_id": "LigandDisplayForward?ligandId=3322", "name": "LigandDisplayForward?ligandId=3322", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6193", "map_id": "LigandDisplayForward?ligandId=6193", "name": "LigandDisplayForward?ligandId=6193", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3334", "map_id": "LigandDisplayForward?ligandId=3334", "name": "LigandDisplayForward?ligandId=3334", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10002", "map_id": "LigandDisplayForward?ligandId=10002", "name": "LigandDisplayForward?ligandId=10002", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10346", "map_id": "LigandDisplayForward?ligandId=10346", "name": "LigandDisplayForward?ligandId=10346", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3340", "map_id": "LigandDisplayForward?ligandId=3340", "name": "LigandDisplayForward?ligandId=3340", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=3634", "map_id": "LigandDisplayForward?ligandId=3634", "name": "LigandDisplayForward?ligandId=3634", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5861", "map_id": "LigandDisplayForward?ligandId=5861", "name": "LigandDisplayForward?ligandId=5861", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665771", "map_id": "none", "name": "CYSLTR1:CYSLTR1 antagonists", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665777", "map_id": "none", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616587", "map_id": "none", "name": "CYSLTR1:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605534", "map_id": "none", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605529", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605531", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):DAG:IP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663233", "map_id": "none", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663231", "map_id": "none", "name": "G alpha (q):GTP:RGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662887", "map_id": "none", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10662879", "map_id": "none", "name": "G alpha (i):GTP:SRC-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665804", "map_id": "none", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10665800", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10665802", "map_id": "none", "name": "HRH3:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617640", "map_id": "none", "name": "Proteinase-activated receptors can bind thrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616635", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10605556", "map_id": "none", "name": "activated thrombin (factor IIa)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10616639", "map_id": "none", "name": "Thrombin:Proteinase-activated receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618989", "map_id": "none", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618611", "map_id": "none", "name": "RhoA,B,C:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613432", "map_id": "none", "name": "GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21653", "map_id": "Q21653", "name": "osg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019832", "map_id": "WBGene00019832", "name": "osg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYI7", "map_id": "H2KYI7", "name": "cgef-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006496", "map_id": "WBGene00006496", "name": "cgef-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECK4", "map_id": "G5ECK4", "name": "DNMBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044989", "map_id": "WBGene00044989", "name": "DNMBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AQN0", "map_id": "A0A0K3AQN0", "name": "ARHGEF28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013682", "map_id": "WBGene00013682", "name": "ARHGEF28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01847", "map_id": "O01847", "name": "tiam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015704", "map_id": "WBGene00015704", "name": "tiam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF62", "map_id": "G5EF62", "name": "uig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009337", "map_id": "WBGene00009337", "name": "uig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U364", "map_id": "Q9U364", "name": "ect-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002297", "map_id": "WBGene00002297", "name": "ect-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965J0", "map_id": "Q965J0", "name": "ephx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019487", "map_id": "WBGene00019487", "name": "ephx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X5LV34", "map_id": "X5LV34", "name": "exc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001366", "map_id": "WBGene00001366", "name": "exc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "S6EZU2", "map_id": "S6EZU2", "name": "rhgf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006476", "map_id": "WBGene00006476", "name": "rhgf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AS36", "map_id": "A0A0K3AS36", "name": "itsn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Y116A8C.36d", "map_id": "Y116A8C.36d", "name": "itsn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662908", "map_id": "none", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662891", "map_id": "none", "name": "Active PAK1:ARHGEF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662910", "map_id": "none", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608722", "map_id": "none", "name": "Homologues of CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10662893", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663227", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663225", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P49809", "map_id": "P49809", "name": "egl-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001179", "map_id": "WBGene00001179", "name": "egl-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17589", "map_id": "O17589", "name": "eat-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001145", "map_id": "WBGene00001145", "name": "eat-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663223", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664441", "map_id": "none", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617862", "map_id": "none", "name": "AKT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612150", "map_id": "Q9UA62", "name": "PDPK1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664439", "map_id": "none", "name": "PDK1:AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663245", "map_id": "none", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10621703", "map_id": "none", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444840", "map_id": "none", "name": "Bile acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:16755", "map_id": "CHEBI:16755", "name": "CHEBI:16755", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176655", "map_id": "CHEBI:16325", "name": "LCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5357505", "map_id": "CHEBI:28834", "name": "DCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_193451", "map_id": "CHEBI:16359", "name": "cholate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10616457", "map_id": "none", "name": "Homologues of GPBAR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616459", "map_id": "none", "name": "GPBAR1: Bile acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619074", "map_id": "none", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616834", "map_id": "none", "name": "GABBR1:GABBR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616836", "map_id": "none", "name": "GABBR1:GABBR2:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624994", "map_id": "none", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10618118", "map_id": "none", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613395", "map_id": "none", "name": "Homologues of ARHGEF12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618116", "map_id": "none", "name": "G-protein alpha (12/13):LARG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663240", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663235", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665930", "map_id": "none", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10665926", "map_id": "G5EGH0", "name": "ser-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10665928", "map_id": "none", "name": "HTR1A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618047", "map_id": "none", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618044", "map_id": "none", "name": "G-protein beta-gamma:PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618122", "map_id": "none", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615544", "map_id": "none", "name": "Homologues of PLXNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "U4PRY7", "map_id": "U4PRY7", "name": "plx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004047", "map_id": "WBGene00004047", "name": "plx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45657", "map_id": "O45657", "name": "plx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004048", "map_id": "WBGene00004048", "name": "plx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618120", "map_id": "none", "name": "G-protein alpha (12/13):LARG:Plexin B1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663237", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10616503", "map_id": "none", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616494", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616500", "map_id": "none", "name": "GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624990", "map_id": "none", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_791498", "map_id": "none", "name": "Ligands of GPCRs that activate G12/13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10618731", "map_id": "none", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616556", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10616558", "map_id": "none", "name": "P2RY10:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662904", "map_id": "none", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10647117", "map_id": "none", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646873", "map_id": "none", "name": "MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "P34379", "map_id": "P34379", "name": "atg-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017045", "map_id": "WBGene00017045", "name": "atg-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XH2", "map_id": "Q95XH2", "name": "epg-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022078", "map_id": "WBGene00022078", "name": "epg-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22342", "map_id": "Q22342", "name": "epg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020334", "map_id": "WBGene00020334", "name": "epg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647115", "map_id": "none", "name": "MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10647434", "map_id": "none", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647395", "map_id": "Q10931", "name": "lgg-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647430", "map_id": "none", "name": "ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBK4", "map_id": "G5EBK4", "name": "atg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010882", "map_id": "WBGene00010882", "name": "atg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647432", "map_id": "none", "name": "ATG12:ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647477", "map_id": "none", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647369", "map_id": "none", "name": "LC3 family", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09490", "map_id": "Q09490", "name": "lgg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002980", "map_id": "WBGene00002980", "name": "lgg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647441", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647419", "map_id": "none", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647417", "map_id": "none", "name": "Beclin-1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q23669", "map_id": "Q23669", "name": "vps-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014151", "map_id": "WBGene00014151", "name": "vps-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22592", "map_id": "Q22592", "name": "phospho-bec-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000247", "map_id": "WBGene00000247", "name": "phospho-bec-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWQ4", "map_id": "Q9XWQ4", "name": "epg-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013695", "map_id": "WBGene00013695", "name": "epg-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXI7", "map_id": "Q9TXI7", "name": "vps-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006932", "map_id": "WBGene00006932", "name": "vps-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646885", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10632891", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10647288", "map_id": "none", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646856", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647285", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646893", "map_id": "none", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10646897", "map_id": "none", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646612", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646861", "map_id": "none", "name": "MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10647615", "map_id": "none", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647445", "map_id": "none", "name": "LC3:CysO263-ATG3:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N369", "map_id": "Q9N369", "name": "atg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021922", "map_id": "WBGene00021922", "name": "atg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647377", "map_id": "none", "name": "CysO263-ATG3:LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647545", "map_id": "none", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10647536", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10647541", "map_id": "Q9TXN6", "name": "atg-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "WBGene00020706", "map_id": "WBGene00020706", "name": "atg-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646859", "map_id": "none", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646624", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646627", "map_id": "none", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646614", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647428", "map_id": "none", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10632839", "map_id": "none", "name": "BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10632894", "map_id": "none", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10632841", "map_id": "none", "name": "AMBRA1:DYNLL1,DYNLL2:BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10632847", "map_id": "none", "name": "BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647448", "map_id": "none", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647443", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7:ATG3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647409", "map_id": "none", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5681998", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10647379", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10647381", "map_id": "Q9N369", "name": "atg-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647406", "map_id": "none", "name": "ATG16L1 complex:WIPI2:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_5334668", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q19124", "map_id": "Q19124", "name": "atg-16.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017178", "map_id": "WBGene00017178", "name": "atg-16.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16466", "map_id": "O16466", "name": "atg-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018294", "map_id": "WBGene00018294", "name": "atg-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09406", "map_id": "Q09406", "name": "atg-16.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019427", "map_id": "WBGene00019427", "name": "atg-16.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647424", "map_id": "none", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10646878", "map_id": "none", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10647475", "map_id": "none", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647456", "map_id": "none", "name": "LC3 family precursors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647472", "map_id": "none", "name": "ATG4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1N6", "map_id": "Q9U1N6", "name": "atg-4.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014080", "map_id": "WBGene00014080", "name": "atg-4.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8ESC5", "map_id": "K8ESC5", "name": "atg-4.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013595", "map_id": "WBGene00013595", "name": "atg-4.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647422", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10633217", "map_id": "Q22712", "name": "mtm-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003476", "map_id": "WBGene00003476", "name": "mtm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664110", "map_id": "none", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647611", "map_id": "none", "name": "ATG12:ATG7:CysO572-ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647532", "map_id": "none", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10647613", "map_id": "none", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10646888", "map_id": "none", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10647276", "map_id": "none", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10606979", "map_id": "none", "name": "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10646871", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647565", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10647556", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10647563", "map_id": "none", "name": "UVRAG complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A7DT33", "map_id": "A7DT33", "name": "UVRAG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021319", "map_id": "WBGene00021319", "name": "UVRAG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625721", "map_id": "none", "name": "ESCRT-III", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2F6", "map_id": "Q9U2F6", "name": "vps-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012903", "map_id": "WBGene00012903", "name": "vps-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL60", "map_id": "Q9BL60", "name": "vps-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022027", "map_id": "WBGene00022027", "name": "vps-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYK4", "map_id": "Q9GYK4", "name": "vps-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020866", "map_id": "WBGene00020866", "name": "vps-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22718", "map_id": "Q22718", "name": "chmp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011976", "map_id": "WBGene00011976", "name": "chmp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21959", "map_id": "Q21959", "name": "CHMP4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020025", "map_id": "WBGene00020025", "name": "CHMP4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18886", "map_id": "Q18886", "name": "vps-32.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016961", "map_id": "WBGene00016961", "name": "vps-32.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02208", "map_id": "O02208", "name": "CHMP2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007216", "map_id": "WBGene00007216", "name": "CHMP2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647681", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10646876", "map_id": "none", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10647313", "map_id": "none", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647309", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86MP3", "map_id": "Q86MP3", "name": "epg-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012641", "map_id": "WBGene00012641", "name": "epg-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693050", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10647311", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10647426", "map_id": "none", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647404", "map_id": "none", "name": "WIPI2:PI(3,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10647402", "map_id": "none", "name": "ATG16L1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10655850", "map_id": "none", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10655844", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649186", "map_id": "none", "name": "USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGG0", "map_id": "G5EGG0", "name": "uso-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010713", "map_id": "WBGene00010713", "name": "uso-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655848", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10655917", "map_id": "none", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10655868", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10655915", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10655871", "map_id": "none", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10655864", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10656339", "map_id": "none", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10656335", "map_id": "none", "name": "cis-Golgi cis SNARE bundle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95ZW1", "map_id": "Q95ZW1", "name": "gos-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017273", "map_id": "WBGene00017273", "name": "gos-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20797", "map_id": "Q20797", "name": "syx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006373", "map_id": "WBGene00006373", "name": "syx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEU1", "map_id": "G5EEU1", "name": "nbet-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043064", "map_id": "WBGene00043064", "name": "nbet-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41941", "map_id": "P41941", "name": "memb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007128", "map_id": "WBGene00007128", "name": "memb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXZ9", "map_id": "Q9TXZ9", "name": "ykt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015164", "map_id": "WBGene00015164", "name": "ykt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656337", "map_id": "none", "name": "cis-SNARE:3xSNAP:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656333", "map_id": "none", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10656329", "map_id": "none", "name": "cis-Golgi t-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10656314", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P91151", "map_id": "P91151", "name": "cogc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016608", "map_id": "WBGene00016608", "name": "cogc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21444", "map_id": "Q21444", "name": "cogc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000585", "map_id": "WBGene00000585", "name": "cogc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3Y1", "map_id": "Q9N3Y1", "name": "GORASP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021536", "map_id": "WBGene00021536", "name": "GORASP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21408", "map_id": "Q21408", "name": "spc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6AW08", "map_id": "Q6AW08", "name": "cogc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022121", "map_id": "WBGene00022121", "name": "cogc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E0AHA7", "map_id": "E0AHA7", "name": "unc-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006803", "map_id": "WBGene00006803", "name": "unc-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21270", "map_id": "Q21270", "name": "cogc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019481", "map_id": "WBGene00019481", "name": "cogc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE66", "map_id": "G5EE66", "name": "cogc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003258", "map_id": "WBGene00003258", "name": "cogc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19989", "map_id": "Q19989", "name": "golg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018017", "map_id": "WBGene00018017", "name": "golg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3K1", "map_id": "Q9U3K1", "name": "TMEM115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008687", "map_id": "WBGene00008687", "name": "TMEM115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XZ0", "map_id": "Q95XZ0", "name": "cogc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021784", "map_id": "WBGene00021784", "name": "cogc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44502", "map_id": "O44502", "name": "cogc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019820", "map_id": "WBGene00019820", "name": "cogc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFW3", "map_id": "G5EFW3", "name": "sma-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004855", "map_id": "WBGene00004855", "name": "sma-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656331", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656176", "map_id": "none", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10656172", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "species_10656174", "map_id": "none", "name": "RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10621209", "map_id": "none", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10621206", "map_id": "none", "name": "ACSL3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10650696", "map_id": "none", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10650680", "map_id": "none", "name": "32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3B6", "map_id": "Q9U3B6", "name": "nol-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010709", "map_id": "WBGene00010709", "name": "nol-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWK5", "map_id": "Q9XWK5", "name": "TEX10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012977", "map_id": "WBGene00012977", "name": "TEX10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y89", "map_id": "Q95Y89", "name": "lpd-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003063", "map_id": "WBGene00003063", "name": "lpd-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2A9", "map_id": "Q9U2A9", "name": "BOP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012978", "map_id": "WBGene00012978", "name": "BOP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91343", "map_id": "P91343", "name": "wdr-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018893", "map_id": "WBGene00018893", "name": "wdr-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23238", "map_id": "Q23238", "name": "ulp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006737", "map_id": "WBGene00006737", "name": "ulp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09353", "map_id": "Q09353", "name": "ulp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006736", "map_id": "WBGene00006736", "name": "ulp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22006", "map_id": "Q22006", "name": "pro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004185", "map_id": "WBGene00004185", "name": "pro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1T1", "map_id": "Q9U1T1", "name": "LAS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012393", "map_id": "WBGene00012393", "name": "LAS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650618", "map_id": "none", "name": "28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10650605", "map_id": "Q9U1T1", "name": "LAS1L", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650694", "map_id": "none", "name": "GNL3:EBNA1BP2:DDX21:PES1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21086", "map_id": "Q21086", "name": "nst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003821", "map_id": "WBGene00003821", "name": "nst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09958", "map_id": "Q09958", "name": "EBNA1BP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015941", "map_id": "WBGene00015941", "name": "EBNA1BP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650610", "map_id": "Q9U3B6", "name": "nol-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650678", "map_id": "none", "name": "PeBoW complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10650964", "map_id": "none", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012966", "map_id": "WBGene00012966", "name": "exos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650949", "map_id": "G5EG59", "name": "crn-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650628", "map_id": "Q23223", "name": "mtr-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650640", "map_id": "G5EBX6", "name": "crn-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10650652", "map_id": "none", "name": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601533", "map_id": "none", "name": "60S ribosomal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10650645", "map_id": "O44406", "name": "eri-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001332", "map_id": "WBGene00001332", "name": "eri-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650650", "map_id": "Q9XXI3", "name": "ISG20L2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012465", "map_id": "WBGene00012465", "name": "ISG20L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650623", "map_id": "Q9N3J4", "name": "C1D", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650635", "map_id": "O16207", "name": "MPHOSPH6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10650630", "map_id": "Q17632", "name": "dis-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001001", "map_id": "WBGene00001001", "name": "dis-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651116", "map_id": "none", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651102", "map_id": "none", "name": "47S pre-rRNA:SSU processome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10651106", "map_id": "none", "name": "45S pre-rRNA:SSU processome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10651111", "map_id": "Q9U299", "name": "xrn-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006964", "map_id": "WBGene00006964", "name": "xrn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650818", "map_id": "none", "name": "UTPC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10650794", "map_id": "P42000", "name": "UTP18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10651114", "map_id": "Q9XTZ2", "name": "rsp-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004705", "map_id": "WBGene00004705", "name": "rsp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650772", "map_id": "none", "name": "UTPA complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663299", "map_id": "none", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663271", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663297", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663273", "map_id": "none", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663263", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663269", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10630255", "map_id": "none", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628778", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10630253", "map_id": "none", "name": "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665597", "map_id": "none", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665595", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598308", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10630260", "map_id": "none", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630257", "map_id": "none", "name": "Ub-p-T401,S672,1035-RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10630229", "map_id": "none", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628790", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628782", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10630226", "map_id": "none", "name": "PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A1N7SYW5", "map_id": "A0A1N7SYW5", "name": "PPP2R3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018373", "map_id": "WBGene00018373", "name": "PPP2R3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630231", "map_id": "none", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628748", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10628604", "map_id": "none", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10628597", "map_id": "none", "name": "STIM1:Calcium", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EF60", "map_id": "G5EF60", "name": "stim-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021910", "map_id": "WBGene00021910", "name": "stim-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628599", "map_id": "none", "name": "STIM1 Dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10628601", "map_id": "none", "name": "ITPR:I(1,4,5)P3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10635753", "map_id": "none", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10635749", "map_id": "Q8I6Y9", "name": "trp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00006615", "map_id": "WBGene00006615", "name": "trp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635751", "map_id": "none", "name": "STIM1:TRPC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8I6Y9", "map_id": "Q8I6Y9", "name": "trp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635700", "map_id": "none", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10635697", "map_id": "none", "name": "CD19 Signalosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10635756", "map_id": "none", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611606", "map_id": "none", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_197965", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200716", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10611656", "map_id": "none", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10611652", "map_id": "none", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200640", "map_id": "CHEBI:65049", "name": "5,10-methenyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611578", "map_id": "none", "name": "MTHFD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21285", "map_id": "Q21285", "name": "dao-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000929", "map_id": "WBGene00000929", "name": "dao-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656006", "map_id": "none", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6808499", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200679", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10656003", "map_id": "none", "name": "ADH1L2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5ECV9", "map_id": "G5ECV9", "name": "phospho-alh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000109", "map_id": "WBGene00000109", "name": "phospho-alh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656014", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656011", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611619", "map_id": "none", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200709", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_200665", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611616", "map_id": "none", "name": "Homologues of SLC19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45166", "map_id": "O45166", "name": "folt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018138", "map_id": "WBGene00018138", "name": "folt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22931", "map_id": "Q22931", "name": "folt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044738", "map_id": "WBGene00044738", "name": "folt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17766", "map_id": "Q17766", "name": "folt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007388", "map_id": "WBGene00007388", "name": "folt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611640", "map_id": "none", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_111355", "map_id": "CHEBI:57453", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611637", "map_id": "Q21084", "name": "slc-25a32", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00010459", "map_id": "WBGene00010459", "name": "slc-25a32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611658", "map_id": "none", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599428", "map_id": "none", "name": "SHMT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P50432", "map_id": "P50432", "name": "mel-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003214", "map_id": "WBGene00003214", "name": "mel-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611608", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611650", "map_id": "none", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611660", "map_id": "none", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655553", "map_id": "none", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803257", "map_id": "CHEBI:63907", "name": "5-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655550", "map_id": "Q9XWE6", "name": "MTHFS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013708", "map_id": "WBGene00013708", "name": "MTHFS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655555", "map_id": "none", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5389850", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6801451", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649578", "map_id": "none", "name": "MTHFD1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10611581", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10649581", "map_id": "none", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10611632", "map_id": "none", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174404", "map_id": "CHEBI:63907", "name": "5-methyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611629", "map_id": "none", "name": "MTHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17693", "map_id": "Q17693", "name": "mthf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015512", "map_id": "WBGene00015512", "name": "mthf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666081", "map_id": "none", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73604", "map_id": "CHEBI:57451", "name": "DHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10666078", "map_id": "none", "name": "DHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93341", "map_id": "Q93341", "name": "dhfr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007974", "map_id": "WBGene00007974", "name": "dhfr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610864", "map_id": "none", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610859", "map_id": "Q93341", "name": "dhfr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611642", "map_id": "none", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610851", "map_id": "Q09509", "name": "FPGS-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017777", "map_id": "WBGene00017777", "name": "FPGS-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610862", "map_id": "none", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610854", "map_id": "none", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611647", "map_id": "none", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10611644", "map_id": "Q09509", "name": "FPGS-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10611622", "map_id": "none", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10602950", "map_id": "none", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602938", "map_id": "none", "name": "Pol II initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NEX2", "map_id": "Q9NEX2", "name": "gtf-2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013736", "map_id": "WBGene00013736", "name": "gtf-2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61707", "map_id": "O61707", "name": "taf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006385", "map_id": "WBGene00006385", "name": "taf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG49", "map_id": "G5EG49", "name": "gtf-2e1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013998", "map_id": "WBGene00013998", "name": "gtf-2e1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44625", "map_id": "O44625", "name": "pqn-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004136", "map_id": "WBGene00004136", "name": "pqn-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45784", "map_id": "O45784", "name": "taf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006391", "map_id": "WBGene00006391", "name": "taf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGM3", "map_id": "G5EGM3", "name": "taf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006382", "map_id": "WBGene00006382", "name": "taf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF68", "map_id": "G5EF68", "name": "taf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006386", "map_id": "WBGene00006386", "name": "taf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18265", "map_id": "Q18265", "name": "fust-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016173", "map_id": "WBGene00016173", "name": "fust-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20788", "map_id": "Q20788", "name": "taf-7.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006388", "map_id": "WBGene00006388", "name": "taf-7.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32085", "map_id": "P32085", "name": "tbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006542", "map_id": "WBGene00006542", "name": "tbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZI6", "map_id": "Q9GZI6", "name": "taf-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006387", "map_id": "WBGene00006387", "name": "taf-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20361", "map_id": "Q20361", "name": "taf-11.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006395", "map_id": "WBGene00006395", "name": "taf-11.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZS0", "map_id": "Q95ZS0", "name": "taf-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006392", "map_id": "WBGene00006392", "name": "taf-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17957", "map_id": "Q17957", "name": "taf-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006397", "map_id": "WBGene00006397", "name": "taf-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16991", "map_id": "O16991", "name": "ttb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006648", "map_id": "WBGene00006648", "name": "ttb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYN3", "map_id": "Q9TYN3", "name": "taf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006383", "map_id": "WBGene00006383", "name": "taf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG47", "map_id": "G5EG47", "name": "gtf-2e2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010054", "map_id": "WBGene00010054", "name": "gtf-2e2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEW8", "map_id": "Q9NEW8", "name": "taf-7.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006389", "map_id": "WBGene00006389", "name": "taf-7.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E9P861", "map_id": "E9P861", "name": "taf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006384", "map_id": "WBGene00006384", "name": "taf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602946", "map_id": "none", "name": "Pol II Initiation complex with phosphodiester-PPi intermediate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602940", "map_id": "none", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602934", "map_id": "none", "name": "pol II open pre-initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602948", "map_id": "none", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602067", "map_id": "none", "name": "pol II transcription complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661007", "map_id": "none", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661003", "map_id": "H2KYY1", "name": "elf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00016029", "map_id": "WBGene00016029", "name": "elf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658637", "map_id": "none", "name": "RUNX1:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95ZL9", "map_id": "Q95ZL9", "name": "bro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000272", "map_id": "WBGene00000272", "name": "bro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFQ5", "map_id": "G5EFQ5", "name": "rnt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004393", "map_id": "WBGene00004393", "name": "rnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661005", "map_id": "none", "name": "RUNX1:CBFB:ELF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2KYY1", "map_id": "H2KYY1", "name": "elf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650030", "map_id": "none", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646645", "map_id": "none", "name": "RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19479", "map_id": "Q19479", "name": "inft-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008848", "map_id": "WBGene00008848", "name": "inft-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP75", "map_id": "Q7JP75", "name": "cyk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000872", "map_id": "WBGene00000872", "name": "cyk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650024", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22915", "map_id": "Q22915", "name": "memo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016500", "map_id": "WBGene00016500", "name": "memo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10650028", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10650026", "map_id": "none", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629231", "map_id": "none", "name": "p-ERBB2 heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10650022", "map_id": "Q22915", "name": "memo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10656931", "map_id": "none", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656927", "map_id": "none", "name": "Unfolded G-protein beta subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617956", "map_id": "none", "name": "CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P47208", "map_id": "P47208", "name": "cct-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000379", "map_id": "WBGene00000379", "name": "cct-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N358", "map_id": "Q9N358", "name": "cct-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021934", "map_id": "WBGene00021934", "name": "cct-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41988", "map_id": "P41988", "name": "cct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000377", "map_id": "WBGene00000377", "name": "cct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47209", "map_id": "P47209", "name": "cct-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000380", "map_id": "WBGene00000380", "name": "cct-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4J8", "map_id": "Q9N4J8", "name": "cct-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018782", "map_id": "WBGene00018782", "name": "cct-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47207", "map_id": "P47207", "name": "cct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000378", "map_id": "WBGene00000378", "name": "cct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46550", "map_id": "P46550", "name": "cct-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000381", "map_id": "WBGene00000381", "name": "cct-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZS5", "map_id": "Q9TZS5", "name": "cct-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020391", "map_id": "WBGene00020391", "name": "cct-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656929", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656937", "map_id": "none", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656935", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657582", "map_id": "none", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657580", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1X7", "map_id": "Q9U1X7", "name": "mau-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003142", "map_id": "WBGene00003142", "name": "mau-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657558", "map_id": "none", "name": "GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10656946", "map_id": "Q9U1X7", "name": "phospho-mau-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10657586", "map_id": "none", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657576", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10657584", "map_id": "none", "name": "GNB5:(RGS7,RGS9,(RGS6,RGS11))", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617960", "map_id": "none", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617912", "map_id": "Q18425", "name": "sphk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007918", "map_id": "WBGene00007918", "name": "sphk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617958", "map_id": "none", "name": "CCT/TRiC:ADP:Sphingosine kinase 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18425", "map_id": "Q18425", "name": "sphk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656989", "map_id": "none", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656983", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605048", "map_id": "none", "name": "G-protein gamma subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10656987", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4:gamma complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657556", "map_id": "none", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657554", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656981", "map_id": "none", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656979", "map_id": "Q9U1X7", "name": "mau-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10656952", "map_id": "none", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10656950", "map_id": "none", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656948", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657590", "map_id": "none", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657588", "map_id": "none", "name": "G-protein heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657578", "map_id": "none", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657574", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621270", "map_id": "none", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10621267", "map_id": "Q8WQB6", "name": "slc-30a5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "WBGene00013668", "map_id": "WBGene00013668", "name": "slc-30a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621299", "map_id": "none", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_437295", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621296", "map_id": "Q19936", "name": "SLC31A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00017954", "map_id": "WBGene00017954", "name": "SLC31A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621278", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10621275", "map_id": "Q22541", "name": "cdf-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "WBGene00011821", "map_id": "WBGene00011821", "name": "cdf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621262", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10621259", "map_id": "Q95QW4", "name": "cdf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000393", "map_id": "WBGene00000393", "name": "cdf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621430", "map_id": "none", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621427", "map_id": "none", "name": "SLC39A8-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22395", "map_id": "Q22395", "name": "zipt-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006486", "map_id": "WBGene00006486", "name": "zipt-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PS08", "map_id": "U4PS08", "name": "zipt-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021936", "map_id": "WBGene00021936", "name": "zipt-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621438", "map_id": "none", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_442320", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10621435", "map_id": "Q9XTQ7", "name": "zipt-7.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00006494", "map_id": "WBGene00006494", "name": "zipt-7.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621254", "map_id": "none", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621251", "map_id": "Q21434", "name": "smf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10662865", "map_id": "none", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29418", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10662862", "map_id": "Q95QW4", "name": "cdf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10621286", "map_id": "none", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10621283", "map_id": "Q45EL5", "name": "toc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00006590", "map_id": "WBGene00006590", "name": "toc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625287", "map_id": "none", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625284", "map_id": "none", "name": "SLC40A1:CP:6Cu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19687", "map_id": "Q19687", "name": "CP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009008", "map_id": "WBGene00009008", "name": "CP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IA95", "map_id": "Q8IA95", "name": "fpn-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021354", "map_id": "WBGene00021354", "name": "fpn-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44607", "map_id": "O44607", "name": "fpn-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019977", "map_id": "WBGene00019977", "name": "fpn-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_936901", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10621419", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621416", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "CHEBI:28694", "map_id": "CHEBI:28694", "name": "CHEBI:28694", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621507", "map_id": "none", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_114632", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621504", "map_id": "none", "name": "SLC41A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O44196", "map_id": "O44196", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022682", "map_id": "WBGene00022682", "name": "SLC41A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02340", "map_id": "O02340", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45182", "map_id": "O45182", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621483", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621480", "map_id": "none", "name": "SLC39A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91348", "map_id": "P91348", "name": "zipt-2.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018897", "map_id": "WBGene00018897", "name": "zipt-2.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWH3", "map_id": "Q9XWH3", "name": "zipt-2.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013207", "map_id": "WBGene00013207", "name": "zipt-2.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62192", "map_id": "O62192", "name": "zipt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009286", "map_id": "WBGene00009286", "name": "zipt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09957", "map_id": "Q09957", "name": "zipt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015940", "map_id": "WBGene00015940", "name": "zipt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6BEU0", "map_id": "Q6BEU0", "name": "zipt-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014669", "map_id": "WBGene00014669", "name": "zipt-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19913", "map_id": "Q19913", "name": "zipt-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017936", "map_id": "WBGene00017936", "name": "zipt-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621397", "map_id": "none", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621394", "map_id": "none", "name": "ZIP6/ZIP14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606319", "map_id": "none", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600814", "map_id": "Q9XTZ2", "name": "rsp-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600824", "map_id": "Q9U1Q3", "name": "cyn-15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000891", "map_id": "WBGene00000891", "name": "cyn-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600812", "map_id": "Q8WQF3", "name": "smg-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600819", "map_id": "Q09385", "name": "syf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00019402", "map_id": "WBGene00019402", "name": "syf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600828", "map_id": "none", "name": "Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09385", "map_id": "Q09385", "name": "syf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1Q3", "map_id": "Q9U1Q3", "name": "cyn-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606328", "map_id": "none", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602797", "map_id": "none", "name": "NXF1,2:NXT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606325", "map_id": "none", "name": "DDX39B:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602803", "map_id": "none", "name": "NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604765", "map_id": "none", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604757", "map_id": "none", "name": "Mature intronless transcript derived Histone pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10600802", "map_id": "none", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600774", "map_id": "Q9BL61", "name": "EIF4A3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600769", "map_id": "none", "name": "Cleavage and Polyadenylation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600662", "map_id": "none", "name": "Spliceosomal B Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O01524", "map_id": "O01524", "name": "sart-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017605", "map_id": "WBGene00017605", "name": "sart-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XD4", "map_id": "Q95XD4", "name": "lsm-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003082", "map_id": "WBGene00003082", "name": "lsm-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09584", "map_id": "Q09584", "name": "rnp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004390", "map_id": "WBGene00004390", "name": "rnp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18942", "map_id": "Q18942", "name": "prp-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008380", "map_id": "WBGene00008380", "name": "prp-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N592", "map_id": "Q9N592", "name": "prp-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022458", "map_id": "WBGene00022458", "name": "prp-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23543", "map_id": "Q23543", "name": "lsm-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003081", "map_id": "WBGene00003081", "name": "lsm-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUY1", "map_id": "Q9XUY1", "name": "wbp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010159", "map_id": "WBGene00010159", "name": "wbp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21739", "map_id": "Q21739", "name": "snrp-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011035", "map_id": "WBGene00011035", "name": "snrp-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90815", "map_id": "P90815", "name": "SNRPC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017238", "map_id": "WBGene00017238", "name": "SNRPC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44787", "map_id": "O44787", "name": "usp-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017280", "map_id": "WBGene00017280", "name": "usp-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1W8", "map_id": "Q9U1W8", "name": "lsm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003077", "map_id": "WBGene00003077", "name": "lsm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52018", "map_id": "P52018", "name": "cyn-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000887", "map_id": "WBGene00000887", "name": "cyn-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21486", "map_id": "Q21486", "name": "prp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010844", "map_id": "WBGene00010844", "name": "prp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18694", "map_id": "O18694", "name": "lsm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003079", "map_id": "WBGene00003079", "name": "lsm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93339", "map_id": "Q93339", "name": "prp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007972", "map_id": "WBGene00007972", "name": "prp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19952", "map_id": "Q19952", "name": "lsm-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003078", "map_id": "WBGene00003078", "name": "lsm-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN6", "map_id": "Q95XN6", "name": "lsm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003080", "map_id": "WBGene00003080", "name": "lsm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600779", "map_id": "O45244", "name": "mog-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600789", "map_id": "G5EBT5", "name": "mog-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600784", "map_id": "Q21924", "name": "gkow-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600127", "map_id": "none", "name": "U1 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600591", "map_id": "O44787", "name": "usp-39", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600461", "map_id": "Q9XUY1", "name": "wbp-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600586", "map_id": "Q21739", "name": "snrp-27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600494", "map_id": "none", "name": "U4 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600643", "map_id": "Q18942", "name": "prp-38", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600533", "map_id": "none", "name": "LSM2-8 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600581", "map_id": "O01524", "name": "sart-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606323", "map_id": "none", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606321", "map_id": "none", "name": "Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602614", "map_id": "none", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10600948", "map_id": "none", "name": "Formation of the Cleavage and Polyadenylation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10600664", "map_id": "none", "name": "Formation of the Spliceosomal B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600660", "map_id": "none", "name": "PPIL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600613", "map_id": "Q20716", "name": "isy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600603", "map_id": "P34313", "name": "bud-31", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600463", "map_id": "none", "name": "Spliceosomal A Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34600", "map_id": "P34600", "name": "PRPF40A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014218", "map_id": "WBGene00014218", "name": "PRPF40A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600638", "map_id": "P91175", "name": "syf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600623", "map_id": "Q18535", "name": "prcc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600608", "map_id": "A9D4S6", "name": "CRNKL1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600593", "map_id": "none", "name": "U4:U5:U6 tri-snRNP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600628", "map_id": "Q22412", "name": "rbm-22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600598", "map_id": "Q9U1Q7", "name": "emb-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600618", "map_id": "Q9U2S6", "name": "cyn-13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600633", "map_id": "Q22836", "name": "SNW1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600267", "map_id": "P34600", "name": "PRPF40A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605855", "map_id": "none", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600844", "map_id": "none", "name": "Magoh-Y14 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600848", "map_id": "none", "name": "pre-EJC:Spliceosomal C:pre-mRNP:CBC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604048", "map_id": "none", "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604042", "map_id": "none", "name": "Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10599879", "map_id": "Q93594", "name": "ncbp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10599884", "map_id": "O01763", "name": "ncbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10645511", "map_id": "none", "name": "The anterograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645507", "map_id": "none", "name": "anterograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "Q95QT8", "map_id": "Q95QT8", "name": "dyf-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001129", "map_id": "WBGene00001129", "name": "dyf-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6I6D4", "map_id": "Q6I6D4", "name": "dyf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001119", "map_id": "WBGene00001119", "name": "dyf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGF0", "map_id": "G5EGF0", "name": "che-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000484", "map_id": "WBGene00000484", "name": "che-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDF6", "map_id": "G5EDF6", "name": "osm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003886", "map_id": "WBGene00003886", "name": "osm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYR7", "map_id": "A8DYR7", "name": "ift-81", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017973", "map_id": "WBGene00017973", "name": "ift-81", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22830", "map_id": "Q22830", "name": "osm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003883", "map_id": "WBGene00003883", "name": "osm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7G4", "map_id": "Q8I7G4", "name": "dyf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001117", "map_id": "WBGene00001117", "name": "dyf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUC2", "map_id": "Q9XUC2", "name": "ifta-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012132", "map_id": "WBGene00012132", "name": "ifta-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C2L6", "map_id": "A0A2C9C2L6", "name": "ift-74", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016005", "map_id": "WBGene00016005", "name": "ift-74", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22752", "map_id": "Q22752", "name": "dyrb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012004", "map_id": "WBGene00012004", "name": "dyrb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8TA52", "map_id": "Q8TA52", "name": "ift-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022465", "map_id": "WBGene00022465", "name": "ift-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93833", "map_id": "Q93833", "name": "che-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000492", "map_id": "WBGene00000492", "name": "che-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0G838", "map_id": "Q0G838", "name": "dyf-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001122", "map_id": "WBGene00001122", "name": "dyf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18917", "map_id": "Q18917", "name": "dylt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017014", "map_id": "WBGene00017014", "name": "dylt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18263", "map_id": "Q18263", "name": "wdr-60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016165", "map_id": "WBGene00016165", "name": "wdr-60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19542", "map_id": "Q19542", "name": "che-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000485", "map_id": "WBGene00000485", "name": "che-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15996", "map_id": "CHEBI:15996", "name": "CHEBI:15996", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17595", "map_id": "Q17595", "name": "dyf-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001127", "map_id": "WBGene00001127", "name": "dyf-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19119", "map_id": "Q19119", "name": "xbx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006960", "map_id": "WBGene00006960", "name": "xbx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645492", "map_id": "none", "name": "dynein-2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10645446", "map_id": "none", "name": "IFT B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10645410", "map_id": "none", "name": "IFT A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10645462", "map_id": "none", "name": "Kinesin-2 motors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10645370", "map_id": "none", "name": "acetylated microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18728", "compartment_display": "axonemal microtubule", "complex": "true" }, { "id": "reaction_10644779", "map_id": "none", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10644777", "map_id": "none", "name": "IFT20:TRIP11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "D0Z5P0", "map_id": "D0Z5P0", "name": "sql-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013730", "map_id": "WBGene00013730", "name": "sql-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644775", "map_id": "D0Z5P0", "name": "sql-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10644770", "map_id": "Q8TA52", "name": "ift-20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10645519", "map_id": "none", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645496", "map_id": "none", "name": "retrograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10645515", "map_id": "none", "name": "retrograde IFT trains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10645509", "map_id": "none", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645390", "map_id": "none", "name": "anterograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10645392", "map_id": "none", "name": "Assembly of the anterograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645336", "map_id": "none", "name": "dynein-2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10645291", "map_id": "none", "name": "IFT B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10645388", "map_id": "none", "name": "active kinesin-2 motors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10645216", "map_id": "none", "name": "IFT A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10645498", "map_id": "none", "name": "Assembly of the retrograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645494", "map_id": "none", "name": "active dynein-2 motors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "reaction_10645517", "map_id": "none", "name": "The retrograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645386", "map_id": "none", "name": "Kinesin-2 motors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10657713", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10657706", "map_id": "Q27481", "name": "uba-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10657711", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657810", "map_id": "none", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10657770", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10657787", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XWF6", "map_id": "Q9XWF6", "name": "ubc-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006711", "map_id": "WBGene00006711", "name": "ubc-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52478", "map_id": "P52478", "name": "ubc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006701", "map_id": "WBGene00006701", "name": "ubc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17720", "map_id": "Q17720", "name": "ubc-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006717", "map_id": "WBGene00006717", "name": "ubc-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91853", "map_id": "P91853", "name": "uev-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006732", "map_id": "WBGene00006732", "name": "uev-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN7", "map_id": "Q95XN7", "name": "ubc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006702", "map_id": "WBGene00006702", "name": "ubc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657808", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657815", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657717", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10657721", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657812", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10657768", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657909", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657902", "map_id": "P0CG71", "name": "ubq-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601455", "map_id": "P0CG71", "name": "ubq-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657906", "map_id": "none", "name": "UCHL3,USP7,USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JKC3", "map_id": "Q7JKC3", "name": "math-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010406", "map_id": "WBGene00010406", "name": "math-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAV3", "map_id": "Q9UAV3", "name": "ubh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006721", "map_id": "WBGene00006721", "name": "ubh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657821", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627924", "map_id": "Q27481", "name": "uba-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657723", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657818", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10657823", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_164121", "map_id": "CHEBI:456215", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10657766", "map_id": "none", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657715", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N2W9", "map_id": "Q9N2W9", "name": "ubc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006705", "map_id": "WBGene00006705", "name": "ubc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34477", "map_id": "P34477", "name": "ubc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006704", "map_id": "WBGene00006704", "name": "ubc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZ69", "map_id": "Q9TZ69", "name": "ubc-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006715", "map_id": "WBGene00006715", "name": "ubc-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1Q1", "map_id": "Q9U1Q1", "name": "ubc-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006709", "map_id": "WBGene00006709", "name": "ubc-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93571", "map_id": "Q93571", "name": "ubc-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006720", "map_id": "WBGene00006720", "name": "ubc-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657764", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10629119", "map_id": "none", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10629114", "map_id": "none", "name": "CA4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q10462", "map_id": "Q10462", "name": "cah-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000283", "map_id": "WBGene00000283", "name": "cah-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629164", "map_id": "none", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621674", "map_id": "none", "name": "Homologues of RHAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22947", "map_id": "Q22947", "name": "rhr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004358", "map_id": "WBGene00004358", "name": "rhr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17463", "map_id": "Q17463", "name": "rhr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004359", "map_id": "WBGene00004359", "name": "rhr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630872", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10630867", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21614", "map_id": "Q21614", "name": "cah-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000282", "map_id": "WBGene00000282", "name": "cah-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629166", "map_id": "none", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352022", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629103", "map_id": "none", "name": "SLC4A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q58QG8", "map_id": "Q58QG8", "name": "abts-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019844", "map_id": "WBGene00019844", "name": "abts-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660894", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660850", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18688", "map_id": "Q18688", "name": "daf-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000915", "map_id": "WBGene00000915", "name": "daf-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8936852", "map_id": "CHEBI:28119", "name": "TCDD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q18888", "map_id": "Q18888", "name": "aipr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016966", "map_id": "WBGene00016966", "name": "aipr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23280", "map_id": "Q23280", "name": "daf-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022599", "map_id": "WBGene00022599", "name": "daf-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660892", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660852", "map_id": "none", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660848", "map_id": "none", "name": "AHR:2xHSP90AB1:AIP:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661709", "map_id": "none", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658641", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10635479", "map_id": "none", "name": "TEAD1:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19849", "map_id": "Q19849", "name": "egl-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001208", "map_id": "WBGene00001208", "name": "egl-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661707", "map_id": "none", "name": "RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661669", "map_id": "none", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639320", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661667", "map_id": "none", "name": "RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10624784", "map_id": "none", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744239", "map_id": "CHEBI:58115", "name": "GMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_744233", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_113578", "map_id": "CHEBI:58115", "name": "GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10624781", "map_id": "Q18779", "name": "sqv-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10624776", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10624773", "map_id": "O44166", "name": "nstp-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00017480", "map_id": "WBGene00017480", "name": "nstp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624779", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742353", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10624768", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10624765", "map_id": "Q968A5", "name": "nstp-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00008237", "map_id": "WBGene00008237", "name": "nstp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624732", "map_id": "none", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_4085435", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109395", "map_id": "CHEBI:60377", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_727815", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10624729", "map_id": "none", "name": "Homologues of SLC35A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95X47", "map_id": "Q95X47", "name": "nstp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015038", "map_id": "WBGene00015038", "name": "nstp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93890", "map_id": "Q93890", "name": "srf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005153", "map_id": "WBGene00005153", "name": "srf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17106", "map_id": "O17106", "name": "nstp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019451", "map_id": "WBGene00019451", "name": "nstp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK5", "map_id": "G5EBK5", "name": "nstp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018414", "map_id": "WBGene00018414", "name": "nstp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01879", "map_id": "O01879", "name": "nstp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022577", "map_id": "WBGene00022577", "name": "nstp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02345", "map_id": "O02345", "name": "nstp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014139", "map_id": "WBGene00014139", "name": "nstp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624786", "map_id": "none", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735698", "map_id": "CHEBI:57865", "name": "UMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_744229", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_744234", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10624737", "map_id": "none", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735692", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1981137", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_735691", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10624734", "map_id": "Q93890", "name": "srf-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10624760", "map_id": "none", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10624757", "map_id": "O16658", "name": "nstp-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00015404", "map_id": "WBGene00015404", "name": "nstp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604090", "map_id": "none", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604083", "map_id": "none", "name": "Editosome (ADAR2) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22618", "map_id": "Q22618", "name": "adr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000080", "map_id": "WBGene00000080", "name": "adr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604087", "map_id": "none", "name": "A to I edited RNA:Editosome (ADAR2) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_76230", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604081", "map_id": "none", "name": "ADAR2 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604085", "map_id": "none", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_75086", "map_id": "none", "name": "dsRNA duplex", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604745", "map_id": "none", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604079", "map_id": "Q22618", "name": "adr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604520", "map_id": "none", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604487", "map_id": "none", "name": "p-S,T-MAP2K2:MAPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604517", "map_id": "none", "name": "p-S,T-MAP2K2:p-T,Y-MAPK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604524", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604483", "map_id": "Q10664", "name": "phospho-mek-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10604515", "map_id": "P39745", "name": "phospho-mpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604489", "map_id": "none", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604485", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599814", "map_id": "none", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599811", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18680", "map_id": "Q18680", "name": "pyp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008149", "map_id": "WBGene00008149", "name": "pyp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622380", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159450", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10622377", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10666164", "map_id": "none", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10666158", "map_id": "none", "name": "p-Y254-RHOU:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19739", "map_id": "Q19739", "name": "chw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009059", "map_id": "WBGene00009059", "name": "chw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666162", "map_id": "none", "name": "p-Y254-RHOU:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10646545", "map_id": "none", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646541", "map_id": "none", "name": "FMNL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34489", "map_id": "P34489", "name": "fozi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010453", "map_id": "WBGene00010453", "name": "fozi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL72", "map_id": "Q9BL72", "name": "frl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021698", "map_id": "WBGene00021698", "name": "frl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646543", "map_id": "none", "name": "CDC42:GTP:FMNL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640507", "map_id": "none", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640503", "map_id": "none", "name": "RHOA:GTP:Mg2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640499", "map_id": "none", "name": "ppDVL:DAAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "D6VPA1", "map_id": "D6VPA1", "name": "daam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018976", "map_id": "WBGene00018976", "name": "daam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22227", "map_id": "Q22227", "name": "phospho-mig-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003241", "map_id": "WBGene00003241", "name": "phospho-mig-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AUI8", "map_id": "A0A0K3AUI8", "name": "phospho-dsh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C34F11.9e", "map_id": "C34F11.9e", "name": "phospho-dsh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18239", "map_id": "Q18239", "name": "phospho-dsh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001102", "map_id": "WBGene00001102", "name": "phospho-dsh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640505", "map_id": "none", "name": "ppDVL:DAAM1:RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663659", "map_id": "none", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663655", "map_id": "none", "name": "RHOA plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45628", "map_id": "O45628", "name": "FAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010433", "map_id": "WBGene00010433", "name": "FAF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93332", "map_id": "Q93332", "name": "gcp-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007954", "map_id": "WBGene00007954", "name": "gcp-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21341", "map_id": "Q21341", "name": "let-99", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002368", "map_id": "WBGene00002368", "name": "let-99", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5PEW5", "map_id": "A5PEW5", "name": "ric-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004364", "map_id": "WBGene00004364", "name": "ric-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEN8", "map_id": "G5EEN8", "name": "aex-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006454", "map_id": "WBGene00006454", "name": "aex-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18598", "map_id": "Q18598", "name": "pmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004059", "map_id": "WBGene00004059", "name": "pmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02495", "map_id": "O02495", "name": "snb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004897", "map_id": "WBGene00004897", "name": "snb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18825", "map_id": "Q18825", "name": "bar-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000238", "map_id": "WBGene00000238", "name": "bar-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91406", "map_id": "P91406", "name": "gcp-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020082", "map_id": "WBGene00020082", "name": "gcp-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10953", "map_id": "Q10953", "name": "wrm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006943", "map_id": "WBGene00006943", "name": "wrm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21018", "map_id": "Q21018", "name": "cri-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010303", "map_id": "WBGene00010303", "name": "cri-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17777", "map_id": "Q17777", "name": "RTKN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007409", "map_id": "WBGene00007409", "name": "RTKN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDU3", "map_id": "G5EDU3", "name": "pld-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004040", "map_id": "WBGene00004040", "name": "pld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92199", "map_id": "P92199", "name": "let-502", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002694", "map_id": "WBGene00002694", "name": "let-502", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTZ5", "map_id": "Q9XTZ5", "name": "maa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007680", "map_id": "WBGene00007680", "name": "maa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KY90", "map_id": "H2KY90", "name": "vang-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015171", "map_id": "WBGene00015171", "name": "vang-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I103", "map_id": "Q8I103", "name": "zoo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013683", "map_id": "WBGene00013683", "name": "zoo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94051", "map_id": "Q94051", "name": "cav-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000301", "map_id": "WBGene00000301", "name": "cav-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01583", "map_id": "O01583", "name": "mrck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006437", "map_id": "WBGene00006437", "name": "mrck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0ILM7", "map_id": "A0A4V0ILM7", "name": "phospho-pkn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009793", "map_id": "WBGene00009793", "name": "phospho-pkn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IKG6", "map_id": "A0A4V0IKG6", "name": "gck-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007287", "map_id": "WBGene00007287", "name": "gck-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20364", "map_id": "Q20364", "name": "sly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009654", "map_id": "WBGene00009654", "name": "sly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09994", "map_id": "Q09994", "name": "ani-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019608", "map_id": "WBGene00019608", "name": "ani-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZH5", "map_id": "H2KZH5", "name": "toe-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016971", "map_id": "WBGene00016971", "name": "toe-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19958", "map_id": "Q19958", "name": "sto-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006064", "map_id": "WBGene00006064", "name": "sto-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23130", "map_id": "Q23130", "name": "rga-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012203", "map_id": "WBGene00012203", "name": "rga-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663657", "map_id": "none", "name": "RHOA:GTP:cytosolic RHOA effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665864", "map_id": "none", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10665860", "map_id": "none", "name": "RHOD mitochondrial outer membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFU0", "map_id": "G5EFU0", "name": "pak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006443", "map_id": "WBGene00006443", "name": "pak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19848", "map_id": "Q19848", "name": "vrk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017895", "map_id": "WBGene00017895", "name": "vrk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665854", "map_id": "none", "name": "RHOD:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10665862", "map_id": "none", "name": "RHOD:GTP:RHOD mitochondrial outer membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10665798", "map_id": "none", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663610", "map_id": "Q20496", "name": "rhi-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004356", "map_id": "WBGene00004356", "name": "rhi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663796", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20496", "map_id": "Q20496", "name": "rhi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646773", "map_id": "none", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646765", "map_id": "none", "name": "Myosin phosphatase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECD7", "map_id": "G5ECD7", "name": "phospho-mel-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003196", "map_id": "WBGene00003196", "name": "phospho-mel-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27497", "map_id": "Q27497", "name": "gsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001747", "map_id": "WBGene00001747", "name": "gsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646770", "map_id": "none", "name": "p-T696-PPP1R12A-Myosin phosphatase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618297", "map_id": "Q17850", "name": "phospho-pak-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10663794", "map_id": "none", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663790", "map_id": "none", "name": "RAC1 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGQ3", "map_id": "G5EGQ3", "name": "max-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003144", "map_id": "WBGene00003144", "name": "max-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5Z2X2", "map_id": "A5Z2X2", "name": "BRK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00303007", "map_id": "WBGene00303007", "name": "BRK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19467", "map_id": "Q19467", "name": "git-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008805", "map_id": "WBGene00008805", "name": "git-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P03949", "map_id": "P03949", "name": "abl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000018", "map_id": "WBGene00000018", "name": "abl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17865", "map_id": "Q17865", "name": "PARD6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007486", "map_id": "WBGene00007486", "name": "PARD6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44518", "map_id": "O44518", "name": "gex-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001579", "map_id": "WBGene00001579", "name": "gex-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVK6", "map_id": "Q9XVK6", "name": "wve-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006958", "map_id": "WBGene00006958", "name": "wve-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46549", "map_id": "P46549", "name": "kin-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002201", "map_id": "WBGene00002201", "name": "kin-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XW5", "map_id": "Q95XW5", "name": "magu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021914", "map_id": "WBGene00021914", "name": "magu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55163", "map_id": "P55163", "name": "gex-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001580", "map_id": "WBGene00001580", "name": "gex-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3S5", "map_id": "Q9N3S5", "name": "ABL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021635", "map_id": "WBGene00021635", "name": "ABL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10929", "map_id": "Q10929", "name": "abi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015146", "map_id": "WBGene00015146", "name": "abi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8F807", "map_id": "K8F807", "name": "nish-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008750", "map_id": "WBGene00008750", "name": "nish-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22682", "map_id": "Q22682", "name": "glt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001622", "map_id": "WBGene00001622", "name": "glt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18685", "map_id": "Q18685", "name": "unc-112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006836", "map_id": "WBGene00006836", "name": "unc-112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAN2", "map_id": "Q9NAN2", "name": "par-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003921", "map_id": "WBGene00003921", "name": "par-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663792", "map_id": "none", "name": "RAC1:GTP:RAC1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665790", "map_id": "none", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646828", "map_id": "none", "name": "RHOB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646655", "map_id": "none", "name": "RHOB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10646685", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646679", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10646683", "map_id": "none", "name": "RHOD:GTP:DIAPH2:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10645649", "map_id": "none", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645638", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612107", "map_id": "none", "name": "CALM1:4Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10645644", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10645640", "map_id": "none", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645636", "map_id": "none", "name": "IQGAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617721", "map_id": "none", "name": "CDC42:GTP, RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636358", "map_id": "none", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635378", "map_id": "none", "name": "Mother filament:branching complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P53489", "map_id": "P53489", "name": "arx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000200", "map_id": "WBGene00000200", "name": "arx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91167", "map_id": "P91167", "name": "ARPC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016729", "map_id": "WBGene00016729", "name": "ARPC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N372", "map_id": "Q9N372", "name": "NCKIPSD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021923", "map_id": "WBGene00021923", "name": "NCKIPSD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61861", "map_id": "O61861", "name": "arx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000205", "map_id": "WBGene00000205", "name": "arx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4M6", "map_id": "Q8I4M6", "name": "phospho-p-Y256-WASL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007840", "map_id": "WBGene00007840", "name": "phospho-p-Y256-WASL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WTM6", "map_id": "Q8WTM6", "name": "arx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021170", "map_id": "WBGene00021170", "name": "arx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PX0", "map_id": "Q95PX0", "name": "nck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006410", "map_id": "WBGene00006410", "name": "nck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4I0", "map_id": "Q9N4I0", "name": "arx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000199", "map_id": "WBGene00000199", "name": "arx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3P6PCS5", "map_id": "A0A3P6PCS5", "name": "arx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000201", "map_id": "WBGene00000201", "name": "arx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P58798", "map_id": "P58798", "name": "arx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000204", "map_id": "WBGene00000204", "name": "arx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWV3", "map_id": "Q9XWV3", "name": "arx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000203", "map_id": "WBGene00000203", "name": "arx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635374", "map_id": "none", "name": "WAVE2, WASP, N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10635408", "map_id": "none", "name": "Mother filament:ARP2/3:actin:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663835", "map_id": "none", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663829", "map_id": "none", "name": "CDC42:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10663831", "map_id": "none", "name": "CDC42 GDIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663833", "map_id": "none", "name": "CDC42:GDP:CDC42 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663622", "map_id": "none", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663620", "map_id": "none", "name": "RHOA:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10645591", "map_id": "none", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645574", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_193079", "map_id": "CHEBI:16422", "name": "ANDST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q27511", "map_id": "Q27511", "name": "htz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019947", "map_id": "WBGene00019947", "name": "htz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10453", "map_id": "Q10453", "name": "his-71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001945", "map_id": "WBGene00001945", "name": "his-71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:29117", "map_id": "CHEBI:29117", "name": "CHEBI:29117", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645588", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663868", "map_id": "none", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663860", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10663856", "map_id": "none", "name": "RHOD:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663865", "map_id": "none", "name": "RHOD GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KZV6", "map_id": "H2KZV6", "name": "ARHGAP26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020209", "map_id": "WBGene00020209", "name": "ARHGAP26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2K5AU23", "map_id": "A0A2K5AU23", "name": "rga-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021324", "map_id": "WBGene00021324", "name": "rga-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635410", "map_id": "none", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612317", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10633825", "map_id": "none", "name": "Mother filament:branching complex:daughter filament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635825", "map_id": "none", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10635822", "map_id": "none", "name": "WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10635372", "map_id": "none", "name": "p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616051", "map_id": "P03949", "name": "abl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665794", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665792", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10663685", "map_id": "none", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663681", "map_id": "none", "name": "RHOB effectors (plasma membrane)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663683", "map_id": "none", "name": "RHOB:GTP:cytosolic RHOB effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646783", "map_id": "none", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646779", "map_id": "none", "name": "FLNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646781", "map_id": "none", "name": "p-S144,T423-PAK1:FLNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646707", "map_id": "none", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646694", "map_id": "none", "name": "RHOA:GTP:RTKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646703", "map_id": "Q09506", "name": "txbp-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016678", "map_id": "WBGene00016678", "name": "txbp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646705", "map_id": "none", "name": "RHOA:GTP:RTKN:TAX1BP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09506", "map_id": "Q09506", "name": "txbp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663135", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617736", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617734", "map_id": "none", "name": "Homologues of PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645758", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646791", "map_id": "none", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646788", "map_id": "none", "name": "p-S2152-FLNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663863", "map_id": "none", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10663687", "map_id": "none", "name": "GDIs block activation of RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663616", "map_id": "none", "name": "RHOA GDIs:RHOA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646812", "map_id": "none", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646805", "map_id": "Q7YX00", "name": "phospho-p-T38-PPP1R14A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010109", "map_id": "WBGene00010109", "name": "phospho-p-T38-PPP1R14A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646810", "map_id": "none", "name": "MLCP:p-T38-PPP1R14A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7YX00", "map_id": "Q7YX00", "name": "phospho-p-T38-PPP1R14A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663965", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663957", "map_id": "none", "name": "Homologues of RHOH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BL44", "map_id": "Q9BL44", "name": "RHOH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022177", "map_id": "WBGene00022177", "name": "RHOH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94124", "map_id": "Q94124", "name": "rac-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004287", "map_id": "WBGene00004287", "name": "rac-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663959", "map_id": "none", "name": "RHOH:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664030", "map_id": "none", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10664027", "map_id": "none", "name": "RHOU:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10664007", "map_id": "none", "name": "RHOU:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665788", "map_id": "none", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10665784", "map_id": "none", "name": "RHOB endosome effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665786", "map_id": "none", "name": "RHOB:GTP:RHOB endosome effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10664025", "map_id": "none", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10664021", "map_id": "none", "name": "RHOU effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34574", "map_id": "P34574", "name": "chc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011867", "map_id": "WBGene00011867", "name": "chc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YD4", "map_id": "Q95YD4", "name": "kin-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002213", "map_id": "WBGene00002213", "name": "kin-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17796", "map_id": "Q17796", "name": "hgrs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004101", "map_id": "WBGene00004101", "name": "hgrs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EES9", "map_id": "G5EES9", "name": "txl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021826", "map_id": "WBGene00021826", "name": "txl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01498", "map_id": "O01498", "name": "stam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004109", "map_id": "WBGene00004109", "name": "stam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBY2", "map_id": "U4PBY2", "name": "hum-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002041", "map_id": "WBGene00002041", "name": "hum-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1N7SYP3", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006876", "map_id": "WBGene00006876", "name": "vab-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20398", "map_id": "Q20398", "name": "magu-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009678", "map_id": "WBGene00009678", "name": "magu-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664023", "map_id": "none", "name": "RHOU:GTP:RHOU effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646777", "map_id": "none", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617725", "map_id": "none", "name": "PAK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10635289", "map_id": "H2KYX3", "name": "nfm-1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003593", "map_id": "WBGene00003593", "name": "nfm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646775", "map_id": "none", "name": "PAK1:NF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KYX3", "map_id": "H2KYX3", "name": "nfm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645608", "map_id": "none", "name": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645605", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628328", "map_id": "Q9XXU5", "name": "amx-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10665811", "map_id": "none", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10663849", "map_id": "none", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663846", "map_id": "none", "name": "CDC42 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVI0", "map_id": "Q9XVI0", "name": "rlbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011970", "map_id": "WBGene00011970", "name": "rlbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF80", "map_id": "G5EF80", "name": "spv-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014051", "map_id": "WBGene00014051", "name": "spv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW53", "map_id": "Q9XW53", "name": "rga-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013135", "map_id": "WBGene00013135", "name": "rga-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20440", "map_id": "Q20440", "name": "gei-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001559", "map_id": "WBGene00001559", "name": "gei-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965N4", "map_id": "Q965N4", "name": "chin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015267", "map_id": "WBGene00015267", "name": "chin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PAK0", "map_id": "U4PAK0", "name": "rga-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007064", "map_id": "WBGene00007064", "name": "rga-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZV4", "map_id": "H2KZV4", "name": "ARAP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017760", "map_id": "WBGene00017760", "name": "ARAP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645560", "map_id": "none", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645540", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10645557", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10651401", "map_id": "none", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1524165", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629751", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10651398", "map_id": "none", "name": "PIK3C3:PIK3R4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10663703", "map_id": "none", "name": "RHOC GAPs stimulate RHOC GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663700", "map_id": "none", "name": "RHOC GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664051", "map_id": "none", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10664049", "map_id": "none", "name": "RHOV:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10664034", "map_id": "none", "name": "RHOV:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646846", "map_id": "none", "name": "CIT-3 binds DLG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646842", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:CIT-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646844", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663131", "map_id": "none", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663128", "map_id": "none", "name": "RHOA GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01443", "map_id": "O01443", "name": "rga-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015303", "map_id": "WBGene00015303", "name": "rga-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AW57", "map_id": "A0A0K3AW57", "name": "rga-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Y75B7AL.4c", "map_id": "Y75B7AL.4c", "name": "rga-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635383", "map_id": "none", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635358", "map_id": "none", "name": "p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663692", "map_id": "none", "name": "RHOC GEFs activate RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663689", "map_id": "none", "name": "RHOC GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636374", "map_id": "none", "name": "Src phosphorylate WASP,N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636371", "map_id": "none", "name": "CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10635306", "map_id": "none", "name": "CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611901", "map_id": "Q95YD4", "name": "kin-32", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646698", "map_id": "none", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617024", "map_id": "A5PEX5", "name": "lin-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00002996", "map_id": "WBGene00002996", "name": "lin-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646696", "map_id": "none", "name": "RHOA:GTP:RTKN:LIN7B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A5PEX5", "map_id": "A5PEX5", "name": "lin-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645075", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645069", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10645073", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663754", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663751", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665856", "map_id": "none", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10646651", "map_id": "none", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646643", "map_id": "none", "name": "DIAPH1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666148", "map_id": "none", "name": "RHOC translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10663963", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663961", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663669", "map_id": "none", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663663", "map_id": "Q20496", "name": "rhi-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10663661", "map_id": "none", "name": "RHOB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10663667", "map_id": "none", "name": "RHOB:GDP:RHOB GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664047", "map_id": "none", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10664043", "map_id": "none", "name": "RHOV effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22866", "map_id": "Q22866", "name": "lev-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002978", "map_id": "WBGene00002978", "name": "lev-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664045", "map_id": "none", "name": "RHOV:GTP:RHOV effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10635380", "map_id": "none", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635376", "map_id": "none", "name": "WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620766", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646757", "map_id": "none", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646734", "map_id": "none", "name": "Smooth muscle/non-muscle myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20238", "map_id": "Q20238", "name": "cal-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009585", "map_id": "WBGene00009585", "name": "cal-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20641", "map_id": "Q20641", "name": "nmy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003776", "map_id": "WBGene00003776", "name": "nmy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19626", "map_id": "P19626", "name": "phospho-mlc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003370", "map_id": "WBGene00003370", "name": "phospho-mlc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q69Z12", "map_id": "Q69Z12", "name": "mlc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023451", "map_id": "WBGene00023451", "name": "mlc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBY3", "map_id": "G5EBY3", "name": "nmy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003777", "map_id": "WBGene00003777", "name": "nmy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53014", "map_id": "P53014", "name": "mlc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003371", "map_id": "WBGene00003371", "name": "mlc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09510", "map_id": "Q09510", "name": "phospho-mlc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003372", "map_id": "WBGene00003372", "name": "phospho-mlc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI9", "map_id": "Q9XVI9", "name": "mlc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011734", "map_id": "WBGene00011734", "name": "mlc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19625", "map_id": "P19625", "name": "phospho-mlc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003369", "map_id": "WBGene00003369", "name": "phospho-mlc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21201", "map_id": "Q21201", "name": "mlc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010554", "map_id": "WBGene00010554", "name": "mlc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646754", "map_id": "none", "name": "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618307", "map_id": "none", "name": "Homologues of p-S141,T402-PAK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640501", "map_id": "none", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640472", "map_id": "none", "name": "pp-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640497", "map_id": "D6VPA1", "name": "daam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646808", "map_id": "none", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646802", "map_id": "Q7YX00", "name": "PPP1R14A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10645086", "map_id": "A0A4V0ILM7", "name": "phospho-pkn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10662944", "map_id": "none", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662941", "map_id": "none", "name": "RHOA GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEN3", "map_id": "G5EEN3", "name": "ced-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000419", "map_id": "WBGene00000419", "name": "ced-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635291", "map_id": "none", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635282", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:PAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646561", "map_id": "none", "name": "FMNL3 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646557", "map_id": "none", "name": "FMNL3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646559", "map_id": "none", "name": "RHOC:GTP:FMNL3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665870", "map_id": "none", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665868", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10663881", "map_id": "none", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646677", "map_id": "none", "name": "RHOD:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10663877", "map_id": "none", "name": "RHOD endosome effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XTB5", "map_id": "Q9XTB5", "name": "lem-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002275", "map_id": "WBGene00002275", "name": "lem-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10956", "map_id": "Q10956", "name": "hpo-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015148", "map_id": "WBGene00015148", "name": "hpo-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663879", "map_id": "none", "name": "RHOD:GTP:RHOD endosome effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10663710", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663707", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3AR51", "map_id": "A0A0K3AR51", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F22G12.5c", "map_id": "F22G12.5c", "name": "DOCK11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646681", "map_id": "none", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646673", "map_id": "none", "name": "DIAPH2-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10645071", "map_id": "none", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645059", "map_id": "A0A4V0ILM7", "name": "pkn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10645067", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10645765", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645762", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618313", "map_id": "none", "name": "p-S,T-PAK1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663883", "map_id": "none", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10663698", "map_id": "none", "name": "RHOC binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663694", "map_id": "none", "name": "RHOC effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663696", "map_id": "none", "name": "RHOC:GTP:RHOC effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646549", "map_id": "none", "name": "FMNL2 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646547", "map_id": "none", "name": "RHOC:GTP:FMNL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646669", "map_id": "none", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646665", "map_id": "none", "name": "DIAPH1,DIAPH3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646667", "map_id": "none", "name": "RHOB:GTP:DIAPH1,DIAPH3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10645646", "map_id": "none", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645642", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAP:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665850", "map_id": "none", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665846", "map_id": "none", "name": "RHOD plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2A6", "map_id": "Q9U2A6", "name": "efhd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012980", "map_id": "WBGene00012980", "name": "efhd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22422", "map_id": "Q22422", "name": "gem-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001577", "map_id": "WBGene00001577", "name": "gem-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665848", "map_id": "none", "name": "RHOD:GTP:RHOD plasma membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10645755", "map_id": "none", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10645739", "map_id": "none", "name": "GOPC:CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "O18302", "map_id": "O18302", "name": "gopc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014101", "map_id": "WBGene00014101", "name": "gopc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645753", "map_id": "none", "name": "GOPC:CFTR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10663674", "map_id": "none", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663671", "map_id": "none", "name": "RHOB GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663133", "map_id": "none", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617740", "map_id": "none", "name": "PAK3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645760", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617738", "map_id": "Q17850", "name": "pak-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665919", "map_id": "none", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10665915", "map_id": "none", "name": "RHOD Golgi membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95XR9", "map_id": "Q95XR9", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022546", "map_id": "WBGene00022546", "name": "VAPB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20981", "map_id": "Q20981", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17099", "map_id": "O17099", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01630", "map_id": "O01630", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QQ9", "map_id": "Q95QQ9", "name": "FILIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016792", "map_id": "WBGene00016792", "name": "FILIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91330", "map_id": "P91330", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44782", "map_id": "O44782", "name": "vpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018008", "map_id": "WBGene00018008", "name": "vpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91915", "map_id": "P91915", "name": "VAPB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDE8", "map_id": "G5EDE8", "name": "ile-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002070", "map_id": "WBGene00002070", "name": "ile-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665917", "map_id": "none", "name": "RHOD:GTP:RHOD Golgi membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10645095", "map_id": "none", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10663842", "map_id": "none", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663839", "map_id": "none", "name": "CDC42 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663679", "map_id": "none", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663676", "map_id": "none", "name": "RHOB GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663618", "map_id": "none", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10664000", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10663996", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N2W5", "map_id": "Q9N2W5", "name": "ubxn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022381", "map_id": "WBGene00022381", "name": "ubxn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34492", "map_id": "P34492", "name": "NIPSNAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019301", "map_id": "WBGene00019301", "name": "NIPSNAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18462", "map_id": "Q18462", "name": "ZAP70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016416", "map_id": "WBGene00016416", "name": "ZAP70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ40", "map_id": "H2KZ40", "name": "WDR11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022459", "map_id": "WBGene00022459", "name": "WDR11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLC2", "map_id": "V6CLC2", "name": "hgap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021209", "map_id": "WBGene00021209", "name": "hgap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62219", "map_id": "O62219", "name": "FAM91A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009366", "map_id": "WBGene00009366", "name": "FAM91A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23571", "map_id": "Q23571", "name": "dbt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014054", "map_id": "WBGene00014054", "name": "dbt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663998", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666146", "map_id": "none", "name": "RHOC activates endoplasmic reticulum effectors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10666142", "map_id": "none", "name": "RHOC endoplasmic reticulum effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P91193", "map_id": "P91193", "name": "maco-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017066", "map_id": "WBGene00017066", "name": "maco-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666144", "map_id": "none", "name": "RHOC:GTP:RHOC endoplasmic reticulum effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10645593", "map_id": "none", "name": "Demethylase KDM1A binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645572", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646582", "map_id": "none", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646573", "map_id": "none", "name": "RAC1:GTP:FMNL1:Profilin:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10646578", "map_id": "Q19370", "name": "srgp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646580", "map_id": "none", "name": "SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10650007", "map_id": "none", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628563", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628579", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663391", "map_id": "none", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663357", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663389", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663332", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663320", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663330", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10625371", "map_id": "none", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613343", "map_id": "Q45FX5", "name": "vav-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625343", "map_id": "Q19019", "name": "phospho-sli-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004829", "map_id": "WBGene00004829", "name": "sli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625369", "map_id": "none", "name": "p(Y700,731,774)-CBL:VAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19019", "map_id": "Q19019", "name": "sli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663909", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10622329", "map_id": "Q22666", "name": "TXLNA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011917", "map_id": "WBGene00011917", "name": "TXLNA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663905", "map_id": "none", "name": "Homologues of STX3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20024", "map_id": "Q20024", "name": "syx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006371", "map_id": "WBGene00006371", "name": "syx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16000", "map_id": "O16000", "name": "unc-64", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006798", "map_id": "WBGene00006798", "name": "unc-64", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91409", "map_id": "P91409", "name": "syx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006374", "map_id": "WBGene00006374", "name": "syx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663907", "map_id": "none", "name": "TXLNA:STX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22666", "map_id": "Q22666", "name": "TXLNA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625148", "map_id": "none", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623793", "map_id": "none", "name": "p85-containing Class 1A PI3Ks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625144", "map_id": "none", "name": "FYN-like kinases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608624", "map_id": "Q19019", "name": "sli-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602400", "map_id": "P29355", "name": "sem-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625146", "map_id": "none", "name": "FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650185", "map_id": "none", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650179", "map_id": "none", "name": "p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10650183", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y614-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625379", "map_id": "none", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625373", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625367", "map_id": "none", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625350", "map_id": "none", "name": "K48polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625345", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625365", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622343", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614058", "map_id": "O16000", "name": "unc-64", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10622331", "map_id": "none", "name": "TXLNA:STX1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10622341", "map_id": "none", "name": "STXA1:SNAP25,STXBP2, VAMP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBK2", "map_id": "G5EBK2", "name": "snb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014084", "map_id": "WBGene00014084", "name": "snb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34815", "map_id": "P34815", "name": "unc-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006757", "map_id": "WBGene00006757", "name": "unc-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94057", "map_id": "Q94057", "name": "snb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044062", "map_id": "WBGene00044062", "name": "snb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34351", "map_id": "P34351", "name": "snb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004899", "map_id": "WBGene00004899", "name": "snb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44412", "map_id": "O44412", "name": "phospho-p-STXBP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020298", "map_id": "WBGene00020298", "name": "phospho-p-STXBP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XH1", "map_id": "Q95XH1", "name": "vamp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022077", "map_id": "WBGene00022077", "name": "vamp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19767", "map_id": "Q19767", "name": "snb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004898", "map_id": "WBGene00004898", "name": "snb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663421", "map_id": "none", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10607317", "map_id": "Q8WQG9", "name": "jnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607331", "map_id": "Q8WQG9", "name": "phospho-jnk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10663322", "map_id": "none", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663310", "map_id": "none", "name": "Homologues of p-Y701-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650009", "map_id": "none", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10650236", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650234", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663381", "map_id": "none", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663365", "map_id": "none", "name": "Homologues of p-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10663367", "map_id": "none", "name": "2 x p-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663314", "map_id": "none", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663312", "map_id": "none", "name": "p-Y-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663482", "map_id": "none", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617052", "map_id": "none", "name": "Homologues of STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650353", "map_id": "none", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650347", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10650351", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663318", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663316", "map_id": "none", "name": "p-STAT5A,p-STAT5B dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663377", "map_id": "none", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663375", "map_id": "none", "name": "2xp-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663359", "map_id": "none", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661639", "map_id": "none", "name": "Homologues of p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650349", "map_id": "none", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650345", "map_id": "none", "name": "p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628569", "map_id": "none", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628561", "map_id": "none", "name": "p-Y701-STAT1, p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628567", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628583", "map_id": "none", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628581", "map_id": "none", "name": "STAT1/3 homo and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622841", "map_id": "none", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622832", "map_id": "none", "name": "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22967", "map_id": "Q22967", "name": "phospho-peli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017766", "map_id": "WBGene00017766", "name": "phospho-peli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622838", "map_id": "none", "name": "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625377", "map_id": "none", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625375", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK:RAPGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650548", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10650546", "map_id": "Q22235", "name": "enpl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00011480", "map_id": "WBGene00011480", "name": "phospho-enpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636285", "map_id": "none", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636283", "map_id": "none", "name": "Ub-SKI/Ub-SKIL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDM7", "map_id": "G5EDM7", "name": "daf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000901", "map_id": "WBGene00000901", "name": "daf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607909", "map_id": "none", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607873", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21733", "map_id": "Q21733", "name": "phospho-daf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000904", "map_id": "WBGene00000904", "name": "phospho-daf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F5GUE5", "map_id": "F5GUE5", "name": "phospho-daf-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000910", "map_id": "WBGene00000910", "name": "phospho-daf-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45897", "map_id": "P45897", "name": "sma-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004858", "map_id": "WBGene00004858", "name": "sma-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607906", "map_id": "none", "name": "Homologues of UBE2D1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636243", "map_id": "none", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636237", "map_id": "none", "name": "p-T-2S-SMAD2,3:SMAD4:NEDDL4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636235", "map_id": "A0A061ACQ8", "name": "NEDD4L", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636241", "map_id": "none", "name": "Ub-p-T-2S-SMAD2,3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636145", "map_id": "none", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10636143", "map_id": "none", "name": "TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P50488", "map_id": "P50488", "name": "daf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000900", "map_id": "WBGene00000900", "name": "daf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDS9", "map_id": "G5EDS9", "name": "tag-68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006445", "map_id": "WBGene00006445", "name": "tag-68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20792", "map_id": "P20792", "name": "phospho-daf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000897", "map_id": "WBGene00000897", "name": "phospho-daf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636343", "map_id": "none", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636336", "map_id": "none", "name": "Ub-SMAD3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635812", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635808", "map_id": "none", "name": "RBL1:E2F4/5:DP1/2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22703", "map_id": "Q22703", "name": "dpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001061", "map_id": "WBGene00001061", "name": "dpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5HWA8", "map_id": "A5HWA8", "name": "efl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001162", "map_id": "WBGene00001162", "name": "efl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF11", "map_id": "G5EF11", "name": "efl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001161", "map_id": "WBGene00001161", "name": "efl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635810", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10635466", "map_id": "none", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635263", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607745", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10635464", "map_id": "none", "name": "WWTR1:p-2S-SMAD2,3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607747", "map_id": "none", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607737", "map_id": "none", "name": "p-2S-SMAD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607715", "map_id": "P45897", "name": "sma-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10642987", "map_id": "none", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10642983", "map_id": "Q9XUY5", "name": "nkb-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "WBGene00010117", "map_id": "WBGene00010117", "name": "nkb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642985", "map_id": "none", "name": "ATP1B4:SNW1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XUY5", "map_id": "Q9XUY5", "name": "nkb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641008", "map_id": "none", "name": "CBL binds TGFBR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607752", "map_id": "P50488", "name": "daf-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10641006", "map_id": "none", "name": "TGFBR2:CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636347", "map_id": "none", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613620", "map_id": "none", "name": "SMAD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10607792", "map_id": "none", "name": "SMAD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636330", "map_id": "none", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_427523", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636312", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4:PARP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636327", "map_id": "none", "name": "PAR-SMAD2,3:PAR-SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427497", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636310", "map_id": "Q9N4H4", "name": "parp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10625009", "map_id": "none", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10625005", "map_id": "none", "name": "Ub-SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10625007", "map_id": "none", "name": "Ub-SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636339", "map_id": "none", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636334", "map_id": "none", "name": "SMAD3:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECY6", "map_id": "G5ECY6", "name": "chn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000500", "map_id": "WBGene00000500", "name": "chn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627446", "map_id": "G5ECY6", "name": "chn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607797", "map_id": "none", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10607794", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:SMAD2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "H2KZI9", "map_id": "H2KZI9", "name": "aka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000101", "map_id": "WBGene00000101", "name": "aka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607778", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10636345", "map_id": "none", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10613608", "map_id": "none", "name": "Homologues of PPM1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10613610", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4:PPM1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636356", "map_id": "none", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636349", "map_id": "Q22712", "name": "mtm-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10636351", "map_id": "none", "name": "p-2S-SMAD2/3:MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q22712", "map_id": "Q22712", "name": "mtm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636305", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636301", "map_id": "none", "name": "Homologues of SP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XW26", "map_id": "Q9XW26", "name": "sptf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012735", "map_id": "WBGene00012735", "name": "sptf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22678", "map_id": "Q22678", "name": "sptf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011926", "map_id": "WBGene00011926", "name": "sptf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636303", "map_id": "none", "name": "p-2S-SMAD2,3:SMAD4:SP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636332", "map_id": "none", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10607782", "map_id": "none", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17941", "compartment_display": "early endosome" }, { "id": "species_10607780", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10636289", "map_id": "none", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636287", "map_id": "none", "name": "Ub-SMAD7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607888", "map_id": "none", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10635770", "map_id": "none", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635768", "map_id": "none", "name": "WWTR1:p-2S-SMAD2,3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636354", "map_id": "none", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10636207", "map_id": "none", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636205", "map_id": "none", "name": "Ub-SMAD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636239", "map_id": "none", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636226", "map_id": "none", "name": "p-T,2S-SMAD2,3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636341", "map_id": "none", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607790", "map_id": "Q21733", "name": "daf-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636233", "map_id": "none", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636230", "map_id": "none", "name": "CDK8:CCNC/ CDK9:CCNT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TYP2", "map_id": "Q9TYP2", "name": "cic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000506", "map_id": "WBGene00000506", "name": "cic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90866", "map_id": "P90866", "name": "cdk-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000409", "map_id": "WBGene00000409", "name": "cdk-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613623", "map_id": "none", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607859", "map_id": "P45897", "name": "sma-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10636245", "map_id": "none", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10640756", "map_id": "none", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617630", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640622", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640625", "map_id": "none", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640620", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640831", "map_id": "none", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640828", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EEE7", "map_id": "G5EEE7", "name": "phospho-vab-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006869", "map_id": "WBGene00006869", "name": "phospho-vab-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3M2", "map_id": "Q9U3M2", "name": "phospho-efn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001163", "map_id": "WBGene00001163", "name": "phospho-efn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44516", "map_id": "O44516", "name": "phospho-efn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001165", "map_id": "WBGene00001165", "name": "phospho-efn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19475", "map_id": "Q19475", "name": "phospho-efn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001164", "map_id": "WBGene00001164", "name": "phospho-efn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633379", "map_id": "none", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090080", "map_id": "CHEBI:63808", "name": "Heparan sulfate chain(5)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10633376", "map_id": "Q9NAP6", "name": "NAGLU(59-743)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00010722", "map_id": "WBGene00010722", "name": "NAGLU(59-743)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635744", "map_id": "none", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634986", "map_id": "none", "name": "HS(3)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q06561", "map_id": "Q06561", "name": "unc-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006787", "map_id": "WBGene00006787", "name": "unc-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGU4", "map_id": "G5EGU4", "name": "gpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001687", "map_id": "WBGene00001687", "name": "gpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECV3", "map_id": "G5ECV3", "name": "GPC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007284", "map_id": "WBGene00007284", "name": "GPC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18530", "map_id": "Q18530", "name": "lon-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003056", "map_id": "WBGene00003056", "name": "lon-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44565", "map_id": "O44565", "name": "lam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002247", "map_id": "WBGene00002247", "name": "lam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635014", "map_id": "none", "name": "HS(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10635741", "map_id": "none", "name": "HS3STs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9TZK5", "map_id": "Q9TZK5", "name": "hst-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002030", "map_id": "WBGene00002030", "name": "hst-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4TTA0", "map_id": "Q4TTA0", "name": "hst-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044303", "map_id": "WBGene00044303", "name": "hst-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10634068", "map_id": "none", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10633892", "map_id": "none", "name": "xylosyl-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634052", "map_id": "none", "name": "Gal-Xyl-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634065", "map_id": "P34548", "name": "sqv-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005021", "map_id": "WBGene00005021", "name": "sqv-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10634930", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633349", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10633006", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10635710", "map_id": "none", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10635705", "map_id": "Q9TZK5", "name": "hst-3.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10632896", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2105012", "map_id": "CHEBI:63852", "name": "GlcNAc-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605658", "map_id": "CHEBI:28037", "name": "GalNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105010", "map_id": "CHEBI:63853", "name": "Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10634893", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634851", "map_id": "none", "name": "Heparan(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634879", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634884", "map_id": "Q966W3", "name": "hst-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002028", "map_id": "WBGene00002028", "name": "hst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635730", "map_id": "none", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634958", "map_id": "none", "name": "HS(2)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10635727", "map_id": "O17645", "name": "hst-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002029", "map_id": "WBGene00002029", "name": "hst-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635764", "map_id": "none", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090075", "map_id": "CHEBI:63503", "name": "linker chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090063", "map_id": "CHEBI:15936", "name": "D-xylose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605637", "map_id": "CHEBI:28061", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10632596", "map_id": "none", "name": "BGAL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "O76632", "map_id": "O76632", "name": "bgal-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019225", "map_id": "WBGene00019225", "name": "bgal-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27526", "map_id": "Q27526", "name": "bgal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011832", "map_id": "WBGene00011832", "name": "bgal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632794", "map_id": "none", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104997", "map_id": "CHEBI:63850", "name": "Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104995", "map_id": "CHEBI:63851", "name": "GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10634060", "map_id": "none", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10633930", "map_id": "none", "name": "Gal-Gal-Xyl-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634057", "map_id": "Q9N491", "name": "sqv-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005020", "map_id": "WBGene00005020", "name": "sqv-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633424", "map_id": "none", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_427963", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10665103", "map_id": "none", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1889970", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10633958", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634019", "map_id": "none", "name": "B3GAT3:Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q09363", "map_id": "Q09363", "name": "sqv-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005026", "map_id": "WBGene00005026", "name": "sqv-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10634024", "map_id": "none", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634021", "map_id": "none", "name": "B3GAT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O62113", "map_id": "O62113", "name": "glct-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008160", "map_id": "WBGene00008160", "name": "glct-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU73", "map_id": "Q9XU73", "name": "glct-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011781", "map_id": "WBGene00011781", "name": "glct-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02304", "map_id": "O02304", "name": "glct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011650", "map_id": "WBGene00011650", "name": "glct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17708", "map_id": "O17708", "name": "glct-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008293", "map_id": "WBGene00008293", "name": "glct-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AUF6", "map_id": "A0A0K3AUF6", "name": "glct-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W07G9.2b", "map_id": "W07G9.2b", "name": "glct-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17751", "map_id": "O17751", "name": "glct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008479", "map_id": "WBGene00008479", "name": "glct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633902", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10633864", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10633897", "map_id": "Q965Q8", "name": "sqv-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005024", "map_id": "WBGene00005024", "name": "sqv-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665106", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065269", "map_id": "CHEBI:63516", "name": "ChEBI:63516 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10635766", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10636009", "map_id": "none", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2142896", "map_id": "none", "name": "HA polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2160848", "map_id": "none", "name": "HA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10630663", "map_id": "G5EE72", "name": "mrp-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003411", "map_id": "WBGene00003411", "name": "mrp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635722", "map_id": "none", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10635042", "map_id": "none", "name": "HS(5)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10635064", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10635715", "map_id": "G5EFN7", "name": "hst-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002031", "map_id": "WBGene00002031", "name": "hst-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635180", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10635066", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10635178", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665110", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10633440", "map_id": "none", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065257", "map_id": "none", "name": "Chondroitin chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:63513", "map_id": "CHEBI:63513", "name": "CHEBI:63513", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63511", "map_id": "CHEBI:63511", "name": "CHEBI:63511", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63512", "map_id": "CHEBI:63512", "name": "CHEBI:63512", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63515", "map_id": "CHEBI:63515", "name": "CHEBI:63515", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635762", "map_id": "none", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10634924", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634921", "map_id": "none", "name": "Heparan(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10646062", "map_id": "none", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646052", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646054", "map_id": "none", "name": "PARP1,PARP2 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5651834", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10646059", "map_id": "Q867X0", "name": "parg-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004051", "map_id": "WBGene00004051", "name": "parg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606556", "map_id": "none", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_163305", "map_id": "none", "name": "mitochondrial DNA promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10606552", "map_id": "none", "name": "Homologues of TFAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94234", "map_id": "Q94234", "name": "hmg-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001975", "map_id": "WBGene00001975", "name": "hmg-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606554", "map_id": "none", "name": "TFAM:mitochondrial promoter complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10606439", "map_id": "none", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606436", "map_id": "Q8I0P7", "name": "phospho-pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604420", "map_id": "none", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604417", "map_id": "none", "name": "PI3K-containing complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604454", "map_id": "none", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604434", "map_id": "none", "name": "AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10604451", "map_id": "none", "name": "p-T309,S474-AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604445", "map_id": "none", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10604441", "map_id": "Q9UA62", "name": "PDPK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10604436", "map_id": "none", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10604432", "map_id": "none", "name": "AKT2:THEM4,TRIB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EED4", "map_id": "G5EED4", "name": "nipi-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010700", "map_id": "WBGene00010700", "name": "nipi-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604425", "map_id": "G5EED4", "name": "nipi-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610560", "map_id": "none", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610557", "map_id": "H2KYI7", "name": "cgef-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10619825", "map_id": "none", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619821", "map_id": "none", "name": "Chromatin with H3K9me2, 5mC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10619819", "map_id": "G5ECR1", "name": "mbd-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10619823", "map_id": "none", "name": "Chromatin (H3K9me2, 5mC):MBD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10619863", "map_id": "none", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614288", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602565", "map_id": "none", "name": "Chromatin (H3K9me2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10619857", "map_id": "none", "name": "eNoSC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44410", "map_id": "O44410", "name": "RRP8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020296", "map_id": "WBGene00020296", "name": "RRP8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21921", "map_id": "Q21921", "name": "sir-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004800", "map_id": "WBGene00004800", "name": "sir-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619860", "map_id": "none", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619843", "map_id": "none", "name": "Chromatin with acetylated H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427498", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10641870", "map_id": "none", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641868", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFT5", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002004", "map_id": "WBGene00002004", "name": "phospho-hsf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641841", "map_id": "G5EFT5", "name": "hsf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641860", "map_id": "Q23280", "name": "daf-41", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641866", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10642922", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10642887", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P11141", "map_id": "P11141", "name": "hsp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002010", "map_id": "WBGene00002010", "name": "hsp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECU5", "map_id": "G5ECU5", "name": "HSPA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009691", "map_id": "WBGene00009691", "name": "HSPA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27420", "map_id": "P27420", "name": "hsp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002007", "map_id": "WBGene00002007", "name": "hsp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC99", "map_id": "G5EC99", "name": "HSPA1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008714", "map_id": "WBGene00008714", "name": "HSPA1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09446", "map_id": "P09446", "name": "hsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002005", "map_id": "WBGene00002005", "name": "hsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45246", "map_id": "O45246", "name": "hsp-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002026", "map_id": "WBGene00002026", "name": "hsp-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20752", "map_id": "Q20752", "name": "stc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006059", "map_id": "WBGene00006059", "name": "stc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8ERU5", "map_id": "K8ERU5", "name": "Hikeshi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018328", "map_id": "WBGene00018328", "name": "Hikeshi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05036", "map_id": "Q05036", "name": "hsp-110", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016250", "map_id": "WBGene00016250", "name": "hsp-110", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642907", "map_id": "none", "name": "HSP70s:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10642885", "map_id": "K8ERU5", "name": "Hikeshi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10642919", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TY07", "map_id": "Q9TY07", "name": "dnj-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001042", "map_id": "WBGene00001042", "name": "dnj-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94216", "map_id": "Q94216", "name": "dnj-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001029", "map_id": "WBGene00001029", "name": "dnj-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641839", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639825", "map_id": "none", "name": "HSF1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641817", "map_id": "none", "name": "p-S230-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641836", "map_id": "none", "name": "CaMKII", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62305", "map_id": "O62305", "name": "phospho-unc-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006779", "map_id": "WBGene00006779", "name": "phospho-unc-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641843", "map_id": "none", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10639827", "map_id": "none", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639821", "map_id": "none", "name": "HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10642845", "map_id": "none", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642788", "map_id": "K8ERU5", "name": "Hikeshi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10642841", "map_id": "none", "name": "HSP70s:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10642843", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10641858", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641822", "map_id": "none", "name": "p-S326-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641855", "map_id": "none", "name": "mTORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639846", "map_id": "none", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639841", "map_id": "A0A0S4XR43", "name": "ccar-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639835", "map_id": "A0A0S4XR43", "name": "phospho-ccar-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639843", "map_id": "Q9N3Q4", "name": "atm-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10643043", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5324631", "map_id": "none", "name": "Ub-protein aggregates", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643038", "map_id": "none", "name": "HSF1:HSP90:HDAC6:VCP:PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10639783", "map_id": "G5EFT5", "name": "hsf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614711", "map_id": "Q23280", "name": "daf-41", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643040", "map_id": "none", "name": "HDAC6:VCP:protein aggregates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10639865", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639788", "map_id": "none", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639786", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610641", "map_id": "none", "name": "Homologues of GSK3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639869", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639867", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10642951", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642942", "map_id": "none", "name": "HSP70s:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10642948", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10641824", "map_id": "none", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641729", "map_id": "none", "name": "HSF1 trimer:target gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641812", "map_id": "none", "name": "Heat shock inducible proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EE36", "map_id": "G5EE36", "name": "hsp-12.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002013", "map_id": "WBGene00002013", "name": "hsp-12.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3B7", "map_id": "Q9U3B7", "name": "hsb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002002", "map_id": "WBGene00002002", "name": "hsb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20363", "map_id": "Q20363", "name": "sip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004798", "map_id": "WBGene00004798", "name": "sip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE65", "map_id": "G5EE65", "name": "hsp-12.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011906", "map_id": "WBGene00011906", "name": "hsp-12.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34696", "map_id": "P34696", "name": "hsp-16.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002015", "map_id": "WBGene00002015", "name": "hsp-16.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17849", "map_id": "Q17849", "name": "hsp-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002023", "map_id": "WBGene00002023", "name": "hsp-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF99", "map_id": "G5EF99", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014233", "map_id": "WBGene00014233", "name": "CRYAB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0L8", "map_id": "B0M0L8", "name": "hsp-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002024", "map_id": "WBGene00002024", "name": "hsp-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19227", "map_id": "Q19227", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02513", "map_id": "P02513", "name": "hsp-16.48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002019", "map_id": "WBGene00002019", "name": "hsp-16.48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06581", "map_id": "P06581", "name": "hsp-16.41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002018", "map_id": "WBGene00002018", "name": "hsp-16.41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06582", "map_id": "P06582", "name": "hsp-16.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002016", "map_id": "WBGene00002016", "name": "hsp-16.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20660", "map_id": "Q20660", "name": "hsp-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002021", "map_id": "WBGene00002021", "name": "hsp-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20164", "map_id": "Q20164", "name": "hsp-12.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002012", "map_id": "WBGene00002012", "name": "hsp-12.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34328", "map_id": "P34328", "name": "hsp-12.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002011", "map_id": "WBGene00002011", "name": "hsp-12.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19228", "map_id": "Q19228", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639832", "map_id": "none", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639830", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10641668", "map_id": "none", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641665", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10609552", "map_id": "none", "name": "Homologues of MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639859", "map_id": "none", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639855", "map_id": "none", "name": "HSBP1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639857", "map_id": "none", "name": "HSBP1:HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639877", "map_id": "none", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605919", "map_id": "P53013", "name": "eft-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001168", "map_id": "WBGene00001168", "name": "eft-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642990", "map_id": "none", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10643016", "map_id": "none", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643006", "map_id": "none", "name": "HSP70 NEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61980", "map_id": "O61980", "name": "unc-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006760", "map_id": "WBGene00006760", "name": "unc-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44739", "map_id": "O44739", "name": "bag-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000236", "map_id": "WBGene00000236", "name": "bag-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643014", "map_id": "none", "name": "ST13 tetramer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE04", "map_id": "G5EE04", "name": "hip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011735", "map_id": "WBGene00011735", "name": "hip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639839", "map_id": "none", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619855", "map_id": "Q21921", "name": "sir-2.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639837", "map_id": "none", "name": "p-T454-DBC1:SIRT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10631172", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_110577", "map_id": "CHEBI:37563", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524101", "map_id": "CHEBI:16337", "name": "PA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1524064", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10631169", "map_id": "P53439", "name": "cdgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00016384", "map_id": "WBGene00016384", "name": "cdgs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640468", "map_id": "none", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631599", "map_id": "Q06561", "name": "unc-52", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10640457", "map_id": "Q06561", "name": "unc-52", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10640455", "map_id": "Q06561", "name": "unc-52", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10640465", "map_id": "none", "name": "BMP1, TLL1, TLL2, Cathepsin L1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9BL26", "map_id": "Q9BL26", "name": "CTSH(116-335)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044760", "map_id": "WBGene00044760", "name": "CTSH(116-335)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20176", "map_id": "Q20176", "name": "nas-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003555", "map_id": "WBGene00003555", "name": "nas-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632241", "map_id": "none", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10632237", "map_id": "none", "name": "Homologues of MMP2(30-660)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631688", "map_id": "none", "name": "MMP14:TIMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21267", "map_id": "Q21267", "name": "phospho-timp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019476", "map_id": "WBGene00019476", "name": "phospho-timp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21265", "map_id": "Q21265", "name": "phospho-tag-225", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019478", "map_id": "WBGene00019478", "name": "phospho-tag-225", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10632239", "map_id": "none", "name": "MMP14:TIMP2:proMMP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10631553", "map_id": "none", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631532", "map_id": "none", "name": "Homologues of MMP2(67-660)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10630560", "map_id": "none", "name": "Homologues of MMP2(110-660)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631550", "map_id": "none", "name": "Homologues of MMP2(67-109)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632145", "map_id": "none", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631644", "map_id": "none", "name": "Homologues of MMP1(54-469)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631571", "map_id": "none", "name": "Homologues of MMP1(84-469)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632142", "map_id": "none", "name": "Homologues of MMP1(54-83)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632289", "map_id": "none", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10632266", "map_id": "none", "name": "MMP14:TIMP2:MMP2 intermediate form", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10632259", "map_id": "none", "name": "Homologues of MMP2(30-66)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632286", "map_id": "none", "name": "MMP14 (16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637134", "map_id": "none", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10631469", "map_id": "none", "name": "Cleaved fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631680", "map_id": "none", "name": "Homologues of MMP14", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615940", "map_id": "none", "name": "Basigin binds Matrix metalloproteinase-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10612925", "map_id": "none", "name": "Homologues of BSG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MQ86", "map_id": "Q8MQ86", "name": "ncam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017184", "map_id": "WBGene00017184", "name": "ncam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18806", "map_id": "Q18806", "name": "rig-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004370", "map_id": "WBGene00004370", "name": "rig-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ60", "map_id": "H2KZ60", "name": "rig-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016354", "map_id": "WBGene00016354", "name": "rig-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615936", "map_id": "none", "name": "Homologues of MMP1(100-469)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10615938", "map_id": "none", "name": "BSG:MMP1(100-469)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10661241", "map_id": "none", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10661232", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00019351", "map_id": "WBGene00019351", "name": "lron-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661238", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10661234", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10661236", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10661248", "map_id": "none", "name": "MMP7 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10661243", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10661245", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10630596", "map_id": "none", "name": "Homologues of MMP7(95-267)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632526", "map_id": "none", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10632183", "map_id": "none", "name": "Homologues of MMP13(20-471)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632524", "map_id": "none", "name": "Homologues of MMP13(20-76)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632425", "map_id": "none", "name": "Homologues of MMP13(77-471)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631748", "map_id": "none", "name": "MMP3, CTSK, CTSL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q2AAB9", "map_id": "Q2AAB9", "name": "CTSH(116-335)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17255", "map_id": "O17255", "name": "CTSH(116-335)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PME4", "map_id": "U4PME4", "name": "CTSH(116-335)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632314", "map_id": "none", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631880", "map_id": "none", "name": "Homologues of MMP9(60-707)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632312", "map_id": "none", "name": "Homologues of MMP9(60-106)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10630632", "map_id": "none", "name": "Homologues of MMP9(107-707)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631900", "map_id": "none", "name": "MMP1 (2, 3, 7, 10, 13)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632506", "map_id": "none", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10632407", "map_id": "none", "name": "Homologues of MMP13(55-471)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632504", "map_id": "none", "name": "Homologues of MMP13(20-54)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632165", "map_id": "none", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10632163", "map_id": "none", "name": "Homologues of MMP11(32-488)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10631589", "map_id": "none", "name": "Homologues of MMP11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632547", "map_id": "none", "name": "Autocatalytic activation of MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10632332", "map_id": "none", "name": "Homologues of MMP7(51-267)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632544", "map_id": "none", "name": "Homologues of MMP7(51-94)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_1604783", "map_id": "none", "name": "Highly sulphated glycosaminoglycans", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:24505", "map_id": "CHEBI:24505", "name": "CHEBI:24505", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661268", "map_id": "none", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10661265", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10630542", "map_id": "none", "name": "Homologues of MMP13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10640453", "map_id": "none", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636728", "map_id": "none", "name": "Homologues of NID1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O44191", "map_id": "O44191", "name": "rme-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004374", "map_id": "WBGene00004374", "name": "rme-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640444", "map_id": "none", "name": "Homologues of NID1(29-?)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10640450", "map_id": "none", "name": "Homologues of NID1(?-1247)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631487", "map_id": "none", "name": "Homologues of MMP19", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632486", "map_id": "none", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10632427", "map_id": "none", "name": "MMP13 intermediate forms", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632483", "map_id": "none", "name": "MMP13 intermediate form fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10640402", "map_id": "none", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640377", "map_id": "none", "name": "Cleaved fibronectin matrix Ala(271)/Val(272)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10640399", "map_id": "none", "name": "Homologues of ADAM8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDW5", "map_id": "G5EDW5", "name": "adm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000074", "map_id": "WBGene00000074", "name": "adm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19844", "map_id": "Q19844", "name": "ADAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017865", "map_id": "WBGene00017865", "name": "ADAM8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFD5", "map_id": "G5EFD5", "name": "unc-71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006804", "map_id": "WBGene00006804", "name": "unc-71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5X7", "map_id": "Q9N5X7", "name": "tag-275", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016423", "map_id": "WBGene00016423", "name": "tag-275", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649493", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696409", "map_id": "CHEBI:16752", "name": "5PHL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5693978", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649490", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P91408", "map_id": "P91408", "name": "eppl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020139", "map_id": "WBGene00020139", "name": "eppl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632389", "map_id": "none", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631787", "map_id": "none", "name": "Homologues of MMP3(55-477)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10632386", "map_id": "none", "name": "Homologues of MMP3(55-99)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631453", "map_id": "none", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631430", "map_id": "none", "name": "Collagen IV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P17139", "map_id": "P17139", "name": "emb-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001263", "map_id": "WBGene00001263", "name": "emb-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630506", "map_id": "none", "name": "Cleaved collagen type IV networks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631450", "map_id": "none", "name": "MMP2,3,4,9,10,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632264", "map_id": "none", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10632261", "map_id": "none", "name": "MMP1,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631751", "map_id": "none", "name": "Activation of proMMP7 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631708", "map_id": "none", "name": "Homologues of MMP7(18-267)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631726", "map_id": "none", "name": "Homologues of MMP7(18-94)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632124", "map_id": "none", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10632044", "map_id": "none", "name": "proMT-MMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "G5EGM1", "map_id": "G5EGM1", "name": "zmp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006987", "map_id": "WBGene00006987", "name": "zmp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10632122", "map_id": "none", "name": "MT-MMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10631903", "map_id": "none", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631862", "map_id": "none", "name": "Homologues of MMP9(20-707)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631898", "map_id": "none", "name": "Homologues of MMP9(20-59)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631945", "map_id": "none", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10623212", "map_id": "none", "name": "Homologues of TIMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10631943", "map_id": "none", "name": "proMMP9:TIMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631594", "map_id": "none", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631591", "map_id": "none", "name": "MMP2,3,7,10,11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10630637", "map_id": "none", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10630634", "map_id": "none", "name": "MMP1-3, 7-9, 12, 13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10640438", "map_id": "none", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614445", "map_id": "none", "name": "Laminin-332", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18823", "map_id": "Q18823", "name": "phospho-lam-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016913", "map_id": "WBGene00016913", "name": "phospho-lam-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECE3", "map_id": "G5ECE3", "name": "lam-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002248", "map_id": "WBGene00002248", "name": "lam-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21313", "map_id": "Q21313", "name": "epi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001328", "map_id": "WBGene00001328", "name": "epi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640436", "map_id": "none", "name": "Cleaved laminin-332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632671", "map_id": "none", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10632669", "map_id": "none", "name": "MT-MMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637180", "map_id": "none", "name": "HSPG2 (perlecan) degradation by MMP14, MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10631601", "map_id": "Q06561", "name": "unc-52", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10631603", "map_id": "Q06561", "name": "unc-52", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10637177", "map_id": "none", "name": "MMP14, MMP15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10631608", "map_id": "none", "name": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631605", "map_id": "none", "name": "MMP3, plasmin, (MMP12)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631690", "map_id": "none", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10631686", "map_id": "none", "name": "Homologues of TIMP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10631514", "map_id": "none", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631511", "map_id": "none", "name": "MMP1, 3, 7, 12, 13, 19, CTSS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10632294", "map_id": "none", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10632291", "map_id": "none", "name": "MMP14:TIMP:MMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608300", "map_id": "none", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608291", "map_id": "none", "name": "RAD9:HUS1:RAD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EC44", "map_id": "G5EC44", "name": "mrt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003417", "map_id": "WBGene00003417", "name": "mrt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q27", "map_id": "Q95Q27", "name": "hpr-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001997", "map_id": "WBGene00001997", "name": "hpr-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFI9", "map_id": "G5EFI9", "name": "hus-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002042", "map_id": "WBGene00002042", "name": "hus-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608295", "map_id": "none", "name": "Rad17-RFC complex bound to DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EGG2", "map_id": "G5EGG2", "name": "hpr-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001998", "map_id": "WBGene00001998", "name": "hpr-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608297", "map_id": "none", "name": "Rad9-Hus1-Rad1 bound to DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636084", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142739", "map_id": "CHEBI:34450", "name": "5,6-EET", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10603812", "map_id": "none", "name": "Homologues of CYP2J2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10636089", "map_id": "none", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636086", "map_id": "none", "name": "CYP(5)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10620836", "map_id": "none", "name": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605504", "map_id": "none", "name": "Integrin alpha2bbeta3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620831", "map_id": "none", "name": "Integrin alpha IIb p(T779)-beta 3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620833", "map_id": "none", "name": "AKT1/PDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615241", "map_id": "none", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10612255", "map_id": "none", "name": "Homologues of FN1(32-2386)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_377604", "map_id": "none", "name": "Integrin binding divalent cations", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10615215", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615239", "map_id": "none", "name": "Focal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615217", "map_id": "none", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615193", "map_id": "none", "name": "Talin:RIAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615213", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616380", "map_id": "none", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616372", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615209", "map_id": "G5ECJ6", "name": "csk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616378", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620443", "map_id": "none", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613787", "map_id": "Q18462", "name": "SYK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615195", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620441", "map_id": "none", "name": "Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615181", "map_id": "none", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615177", "map_id": "P34400", "name": "mig-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615179", "map_id": "none", "name": "Rap1-GTP:PIP2:RIAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616374", "map_id": "none", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10615259", "map_id": "none", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615256", "map_id": "none", "name": "CalDAG-GEFs:DAG:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19770", "map_id": "Q19770", "name": "phospho-rgef-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009100", "map_id": "WBGene00009100", "name": "phospho-rgef-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615232", "map_id": "none", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615191", "map_id": "G5EGK1", "name": "tln-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10620451", "map_id": "none", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620448", "map_id": "none", "name": "Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621581", "map_id": "none", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621575", "map_id": "none", "name": "Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621579", "map_id": "none", "name": "Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615245", "map_id": "none", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602405", "map_id": "Q9N5D3", "name": "sos-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615228", "map_id": "none", "name": "GRB2 bound to pPTK2 in Focal adhesion", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615243", "map_id": "none", "name": "GRB2:SOS:p-PTK2:Focal adhesion", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615237", "map_id": "none", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615204", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615226", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615230", "map_id": "none", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10626050", "map_id": "none", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617231", "map_id": "P34578", "name": "epac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004255", "map_id": "WBGene00004255", "name": "epac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615207", "map_id": "none", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615197", "map_id": "none", "name": "Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616370", "map_id": "none", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616367", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615199", "map_id": "none", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599387", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599384", "map_id": "Q21795", "name": "kmo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011089", "map_id": "WBGene00011089", "name": "kmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659512", "map_id": "none", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352006", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10659509", "map_id": "none", "name": "Homologues of SLC36A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45936", "map_id": "O45936", "name": "slc-36.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012804", "map_id": "WBGene00012804", "name": "slc-36.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18595", "map_id": "Q18595", "name": "slc-36.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016628", "map_id": "WBGene00016628", "name": "slc-36.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62286", "map_id": "O62286", "name": "slc-36.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010421", "map_id": "WBGene00010421", "name": "slc-36.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34479", "map_id": "P34479", "name": "skat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010307", "map_id": "WBGene00010307", "name": "skat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4SQY7", "map_id": "G4SQY7", "name": "slc-36.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020837", "map_id": "WBGene00020837", "name": "slc-36.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX44", "map_id": "Q9XX44", "name": "slc-36.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012629", "map_id": "WBGene00012629", "name": "slc-36.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599379", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599376", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09474", "map_id": "Q09474", "name": "tdo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016201", "map_id": "WBGene00016201", "name": "tdo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599408", "map_id": "none", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30487", "map_id": "CHEBI:15793", "name": "3HAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_36027", "map_id": "CHEBI:29044", "name": "ACS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599405", "map_id": "none", "name": "HAAO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19341", "map_id": "Q19341", "name": "haao-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010595", "map_id": "WBGene00010595", "name": "haao-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625269", "map_id": "none", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893615", "map_id": "CHEBI:17442", "name": "AP-DOBu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625263", "map_id": "none", "name": "PXLP-KYAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MP09", "map_id": "Q8MP09", "name": "nkat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010984", "map_id": "WBGene00010984", "name": "nkat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8939576", "map_id": "none", "name": "I3LACT, I3PROPA", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:55528", "map_id": "CHEBI:55528", "name": "CHEBI:55528", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:43580", "map_id": "CHEBI:43580", "name": "CHEBI:43580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29502", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599398", "map_id": "none", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599395", "map_id": "none", "name": "KYNU dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18026", "map_id": "Q18026", "name": "flu-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015802", "map_id": "WBGene00015802", "name": "flu-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635687", "map_id": "none", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066767", "map_id": "CHEBI:65139", "name": "delta2-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617824", "map_id": "none", "name": "ACOX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10635685", "map_id": "none", "name": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066762", "map_id": "CHEBI:65131", "name": "1-3-oxo-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066765", "map_id": "CHEBI:65132", "name": "DHA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10635683", "map_id": "none", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066766", "map_id": "CHEBI:65130", "name": "1-3-hydroxy-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10635681", "map_id": "none", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10635600", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10617418", "map_id": "O45730", "name": "pmp-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00004061", "map_id": "WBGene00004061", "name": "pmp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635679", "map_id": "none", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10635597", "map_id": "none", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_162743", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046064", "map_id": "CHEBI:456215", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046049", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046062", "map_id": "CHEBI:51985", "name": "ALA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10635594", "map_id": "none", "name": "ACSL1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10635602", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10660616", "map_id": "none", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660614", "map_id": "none", "name": "Ub-NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34707", "map_id": "P34707", "name": "skn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004804", "map_id": "WBGene00004804", "name": "skn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660604", "map_id": "none", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660596", "map_id": "none", "name": "p-NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660602", "map_id": "none", "name": "p-NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10666119", "map_id": "none", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9714134", "map_id": "none", "name": "NFE2L2 inducers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7045", "map_id": "LigandDisplayForward?ligandId=7045", "name": "LigandDisplayForward?ligandId=7045", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5786", "map_id": "LigandDisplayForward?ligandId=5786", "name": "LigandDisplayForward?ligandId=5786", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6569", "map_id": "LigandDisplayForward?ligandId=6569", "name": "LigandDisplayForward?ligandId=6569", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660612", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10666117", "map_id": "none", "name": "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10644873", "map_id": "none", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10644870", "map_id": "none", "name": "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10644868", "map_id": "none", "name": "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626976", "map_id": "none", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964837", "map_id": "CHEBI:60625", "name": "(GlcNAc)3 (Man)5 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_975819", "map_id": "CHEBI:60615", "name": "(GlcNAc)3 (Man)3 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964752", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10626973", "map_id": "none", "name": "MAN2A2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q2PJ74", "map_id": "Q2PJ74", "name": "aman-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010284", "map_id": "WBGene00010284", "name": "aman-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649008", "map_id": "none", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6784247", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784248", "map_id": "CHEBI:59520", "name": "NGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784249", "map_id": "CHEBI:2181", "name": "L-fucose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10649005", "map_id": "none", "name": "FUCA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "P49713", "map_id": "P49713", "name": "FUCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012225", "map_id": "WBGene00012225", "name": "FUCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626984", "map_id": "none", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975822", "map_id": "CHEBI:60651", "name": "(GlcNAc)4 (Man)3 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10626981", "map_id": "O17560", "name": "gly-20", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001645", "map_id": "WBGene00001645", "name": "gly-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649043", "map_id": "none", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5693930", "map_id": "CHEBI:18915", "name": "Gal1,3GlcNAc group", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5693933", "map_id": "CHEBI:18914", "name": "Gal1,3Fuc1,4GlcNAc group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205689", "map_id": "CHEBI:58189", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10649040", "map_id": "none", "name": "Homologues of FUT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18255", "map_id": "Q18255", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016163", "map_id": "WBGene00016163", "name": "FUT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE06", "map_id": "G5EE06", "name": "fut-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043986", "map_id": "WBGene00043986", "name": "fut-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE1", "map_id": "G5EEE1", "name": "fut-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020222", "map_id": "WBGene00020222", "name": "fut-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDR5", "map_id": "G5EDR5", "name": "fut-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001505", "map_id": "WBGene00001505", "name": "fut-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFP5", "map_id": "G5EFP5", "name": "fut-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006402", "map_id": "WBGene00006402", "name": "fut-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEL7", "map_id": "G5EEL7", "name": "fut-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001507", "map_id": "WBGene00001507", "name": "fut-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10628551", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10628548", "map_id": "G5EFE7", "name": "fut-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001508", "map_id": "WBGene00001508", "name": "fut-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604709", "map_id": "none", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604705", "map_id": "G5EBR7", "name": "exo-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604589", "map_id": "none", "name": "UNG-1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U221", "map_id": "Q9U221", "name": "ung-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013241", "map_id": "WBGene00013241", "name": "ung-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604583", "map_id": "Q9U221", "name": "ung-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604707", "map_id": "none", "name": "APEX1:AP-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604711", "map_id": "none", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604605", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P54137", "map_id": "P54137", "name": "nth-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011201", "map_id": "WBGene00011201", "name": "nth-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604576", "map_id": "P54137", "name": "nth-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10626216", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964828", "map_id": "CHEBI:60637", "name": "(GlcNAc)2 (Man)7bc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964740", "map_id": "CHEBI:59087", "name": "(GlcNAc)2 (Man)5 (Asn)1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10626187", "map_id": "none", "name": "MAN1A1/A2/C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P90787", "map_id": "P90787", "name": "mans-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008411", "map_id": "WBGene00008411", "name": "mans-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18788", "map_id": "Q18788", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008258", "map_id": "WBGene00008258", "name": "MAN1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626190", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_915149", "map_id": "CHEBI:59092", "name": "(GlcNAc)2 (Man)9", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10626214", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964831", "map_id": "none", "name": "(GlcNAc)2 (Man)8 glycans", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661498", "map_id": "none", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627710", "map_id": "Q9N373", "name": "lep-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002278", "map_id": "WBGene00002278", "name": "lep-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661496", "map_id": "Q9N373", "name": "phospho-lep-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10620826", "map_id": "none", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_192438", "map_id": "CHEBI:17754", "name": "glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10620823", "map_id": "none", "name": "AQP7 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7Z138", "map_id": "Q7Z138", "name": "aqp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000176", "map_id": "WBGene00000176", "name": "aqp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19949", "map_id": "Q19949", "name": "aqp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000169", "map_id": "WBGene00000169", "name": "aqp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW36", "map_id": "Q9XW36", "name": "aqp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000171", "map_id": "WBGene00000171", "name": "aqp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21473", "map_id": "Q21473", "name": "aqp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000175", "map_id": "WBGene00000175", "name": "aqp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17571", "map_id": "Q17571", "name": "aqp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000170", "map_id": "WBGene00000170", "name": "aqp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWQ1", "map_id": "Q7YWQ1", "name": "aqp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013272", "map_id": "WBGene00013272", "name": "aqp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620807", "map_id": "none", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620804", "map_id": "none", "name": "AQP9 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664833", "map_id": "none", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10664831", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers, GRIN1:GRIN2 tri-heteromers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10620890", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626899", "map_id": "none", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626896", "map_id": "none", "name": "GLRA:GLRB:Gly", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECH3", "map_id": "G5ECH3", "name": "avr-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000233", "map_id": "WBGene00000233", "name": "avr-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QT7", "map_id": "Q95QT7", "name": "glc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001594", "map_id": "WBGene00001594", "name": "glc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17274", "map_id": "O17274", "name": "lgc-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020836", "map_id": "WBGene00020836", "name": "lgc-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N517", "map_id": "Q9N517", "name": "lgc-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021437", "map_id": "WBGene00021437", "name": "lgc-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17328", "map_id": "Q17328", "name": "glc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001592", "map_id": "WBGene00001592", "name": "glc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17402", "map_id": "O17402", "name": "lgc-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017314", "map_id": "WBGene00017314", "name": "lgc-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1N7SYW0", "map_id": "A0A1N7SYW0", "name": "lgc-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021146", "map_id": "WBGene00021146", "name": "lgc-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTP9", "map_id": "Q7YTP9", "name": "lgc-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008076", "map_id": "WBGene00008076", "name": "lgc-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22741", "map_id": "Q22741", "name": "lgc-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020767", "map_id": "WBGene00020767", "name": "lgc-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09453", "map_id": "Q09453", "name": "ggr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001586", "map_id": "WBGene00001586", "name": "ggr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBR3", "map_id": "G5EBR3", "name": "glc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001591", "map_id": "WBGene00001591", "name": "glc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q97", "map_id": "Q95Q97", "name": "avr-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000232", "map_id": "WBGene00000232", "name": "avr-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IN81", "map_id": "A0A4V0IN81", "name": "ggr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001587", "map_id": "WBGene00001587", "name": "ggr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEZ3", "map_id": "G5EEZ3", "name": "glc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001593", "map_id": "WBGene00001593", "name": "glc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IK40", "map_id": "A0A4V0IK40", "name": "lgc-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008022", "map_id": "WBGene00008022", "name": "lgc-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90876", "map_id": "P90876", "name": "lgc-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009790", "map_id": "WBGene00009790", "name": "lgc-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619119", "map_id": "none", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618195", "map_id": "none", "name": "Ca permeable AMPA receptor ligand complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664726", "map_id": "none", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10664722", "map_id": "G5EEH3", "name": "nmr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10664720", "map_id": "G5EGQ9", "name": "nmr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10664724", "map_id": "none", "name": "GRIN1:GRIN2A di-heterotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10628530", "map_id": "none", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10628525", "map_id": "none", "name": "Kir heterotetramers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A1C3NSN6", "map_id": "A0A1C3NSN6", "name": "irk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002150", "map_id": "WBGene00002150", "name": "irk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52192", "map_id": "P52192", "name": "irk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002149", "map_id": "WBGene00002149", "name": "irk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1C3NSK2", "map_id": "A0A1C3NSK2", "name": "irk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002151", "map_id": "WBGene00002151", "name": "irk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628428", "map_id": "none", "name": "GABA B receptor G-protein beta-gamma complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10628527", "map_id": "none", "name": "GABA B receptor G-protein beta-gamma and Kir3 channel complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665455", "map_id": "none", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29804", "map_id": "CHEBI:29103", "name": "K+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10665452", "map_id": "none", "name": "HTR3A pentamer:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61216", "map_id": "O61216", "name": "lgc-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019069", "map_id": "WBGene00019069", "name": "lgc-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54245", "map_id": "P54245", "name": "lgc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017580", "map_id": "WBGene00017580", "name": "lgc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE87", "map_id": "G5EE87", "name": "lgc-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008997", "map_id": "WBGene00008997", "name": "lgc-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3P6P985", "map_id": "A0A3P6P985", "name": "acr-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000060", "map_id": "WBGene00000060", "name": "acr-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665459", "map_id": "none", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665457", "map_id": "none", "name": "HTR3A pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620923", "map_id": "none", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10620920", "map_id": "none", "name": "Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_376186", "map_id": "CHEBI:16523", "name": "D-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9635195", "map_id": "LigandDisplayForward?ligandId=5472", "name": "Ifenprodil", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10628532", "map_id": "none", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10626930", "map_id": "none", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626927", "map_id": "none", "name": "GABRR pentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q17511", "map_id": "Q17511", "name": "lgc-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007191", "map_id": "WBGene00007191", "name": "lgc-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18276", "map_id": "O18276", "name": "gab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001512", "map_id": "WBGene00001512", "name": "gab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626740", "map_id": "none", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626737", "map_id": "none", "name": "GABR heteropentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18812", "map_id": "Q18812", "name": "acc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008280", "map_id": "WBGene00008280", "name": "acc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41849", "map_id": "P41849", "name": "lgc-50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18228", "map_id": "O18228", "name": "lgc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013300", "map_id": "WBGene00013300", "name": "lgc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624481", "map_id": "none", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624478", "map_id": "none", "name": "0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624680", "map_id": "none", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10624476", "map_id": "none", "name": "Highly calcium permeable nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619117", "map_id": "none", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626304", "map_id": "none", "name": "HTR3 pentamers:5HT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618079", "map_id": "none", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608448", "map_id": "none", "name": "Clathrin:AP-2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22601", "map_id": "Q22601", "name": "apa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000161", "map_id": "WBGene00000161", "name": "apa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35603", "map_id": "P35603", "name": "dpy-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001082", "map_id": "WBGene00001082", "name": "dpy-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19123", "map_id": "Q19123", "name": "aps-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000157", "map_id": "WBGene00000157", "name": "aps-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4F3", "map_id": "Q9N4F3", "name": "apb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000160", "map_id": "WBGene00000160", "name": "apb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90961", "map_id": "P90961", "name": "clic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020246", "map_id": "WBGene00020246", "name": "clic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615689", "map_id": "none", "name": "Homologues of L1CAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21465", "map_id": "Q21465", "name": "phospho-zig-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019727", "map_id": "WBGene00019727", "name": "phospho-zig-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRR1", "map_id": "Q5WRR1", "name": "phospho-wrk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006942", "map_id": "WBGene00006942", "name": "phospho-wrk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618077", "map_id": "none", "name": "L1:clathrin-coated vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621804", "map_id": "none", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618081", "map_id": "none", "name": "L1:AP-2 Clathrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "B1V8A0", "map_id": "B1V8A0", "name": "unc-57", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006791", "map_id": "WBGene00006791", "name": "unc-57", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621801", "map_id": "none", "name": "pL1 (S1204, 1248):ERK2:clathrin-dynamin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17940", "compartment_display": "endosome", "complex": "true" }, { "id": "reaction_10624055", "map_id": "none", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608453", "map_id": "B1V8A0", "name": "unc-57", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10609937", "map_id": "none", "name": "Dynamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P39055", "map_id": "P39055", "name": "dyn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001130", "map_id": "WBGene00001130", "name": "dyn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621565", "map_id": "none", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621561", "map_id": "none", "name": "CRMP-2:NUMB:alpha adaptin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21773", "map_id": "Q21773", "name": "phospho-dhp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000963", "map_id": "WBGene00000963", "name": "phospho-dhp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q01630", "map_id": "Q01630", "name": "phospho-unc-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006769", "map_id": "WBGene00006769", "name": "phospho-unc-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18677", "map_id": "Q18677", "name": "phospho-dhp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000964", "map_id": "WBGene00000964", "name": "phospho-dhp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621563", "map_id": "none", "name": "L1:NUMB:CRMP-2:alpha-adaptin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10615724", "map_id": "none", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615720", "map_id": "none", "name": "pL1:Ezrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBK3", "map_id": "G5EBK3", "name": "erm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001333", "map_id": "WBGene00001333", "name": "erm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615722", "map_id": "none", "name": "L1 trans-homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621806", "map_id": "none", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615718", "map_id": "none", "name": "Homologues of p-Y1176-L1CAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621554", "map_id": "none", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621552", "map_id": "none", "name": "pL1:ERM:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618083", "map_id": "none", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "reaction_10638811", "map_id": "none", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638788", "map_id": "none", "name": "TFAP2C homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19862", "map_id": "Q19862", "name": "aptf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009203", "map_id": "WBGene00009203", "name": "aptf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G2HK15", "map_id": "G2HK15", "name": "aptf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013383", "map_id": "WBGene00013383", "name": "aptf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19863", "map_id": "Q19863", "name": "aptf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009202", "map_id": "WBGene00009202", "name": "aptf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09585", "map_id": "Q09585", "name": "aptf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019424", "map_id": "WBGene00019424", "name": "aptf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638809", "map_id": "none", "name": "SUMO1:TFAP2C homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658568", "map_id": "none", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658564", "map_id": "none", "name": "TFAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10658566", "map_id": "none", "name": "TFAP2 homo- and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658586", "map_id": "none", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658582", "map_id": "none", "name": "Homologues of TFAP2C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658584", "map_id": "none", "name": "TFAP2C:WWOX", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10658588", "map_id": "none", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638786", "map_id": "none", "name": "Homologues of TFAP2C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658600", "map_id": "none", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658596", "map_id": "none", "name": "TFAP2B homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10658594", "map_id": "Q21501", "name": "gfl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001585", "map_id": "WBGene00001585", "name": "gfl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658598", "map_id": "none", "name": "TFAP2B homodimer:YEATS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21501", "map_id": "Q21501", "name": "gfl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622688", "map_id": "none", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622641", "map_id": "none", "name": "Homologues of KSRP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91393", "map_id": "P91393", "name": "phospho-fubl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019692", "map_id": "WBGene00019692", "name": "phospho-fubl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BLA0", "map_id": "Q9BLA0", "name": "phospho-fubl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016489", "map_id": "WBGene00016489", "name": "phospho-fubl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23487", "map_id": "Q23487", "name": "phospho-fubl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022738", "map_id": "WBGene00022738", "name": "phospho-fubl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17936", "map_id": "Q17936", "name": "phospho-fubl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007534", "map_id": "WBGene00007534", "name": "phospho-fubl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_450386", "map_id": "none", "name": "mRNA Transcript Targeted by KSRP", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622643", "map_id": "none", "name": "KSRP:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622708", "map_id": "none", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622694", "map_id": "none", "name": "Homologues of YWHAZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622682", "map_id": "none", "name": "Homologues of p-S193-KHSRP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622706", "map_id": "none", "name": "Phosphorylated KSRP (Ser193):14-3-3zeta Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604062", "map_id": "none", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604056", "map_id": "none", "name": "CstF:CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604060", "map_id": "none", "name": "intronless pre-mRNA cleavage complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10620715", "map_id": "none", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429974", "map_id": "none", "name": "mature mRNA (eukaryotic, capped and deadenylated)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_429926", "map_id": "none", "name": "capped oligoribonucleotide", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620712", "map_id": "none", "name": "Exosome:SKI complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A5Z2V7", "map_id": "A5Z2V7", "name": "WDR61", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008533", "map_id": "WBGene00008533", "name": "WDR61", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKR2", "map_id": "Q9BKR2", "name": "ttc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021613", "map_id": "WBGene00021613", "name": "ttc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90922", "map_id": "P90922", "name": "HBS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010622", "map_id": "WBGene00010622", "name": "HBS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19103", "map_id": "Q19103", "name": "skih-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008502", "map_id": "WBGene00008502", "name": "skih-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17632", "map_id": "Q17632", "name": "dis-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649092", "map_id": "none", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_430042", "map_id": "CHEBI:17825", "name": "7MGMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5694090", "map_id": "CHEBI:20794", "name": "7MG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649089", "map_id": "Q09315", "name": "NT5C3B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017775", "map_id": "WBGene00017775", "name": "NT5C3-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622619", "map_id": "none", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622615", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20155", "map_id": "Q20155", "name": "phospho-ccch-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009532", "map_id": "WBGene00009532", "name": "phospho-ccch-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606995", "map_id": "none", "name": "Homologues of YWHAB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622617", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620627", "map_id": "none", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620593", "map_id": "none", "name": "Deadenylated mRNA:Lsm1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20374", "map_id": "Q20374", "name": "patr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009661", "map_id": "WBGene00009661", "name": "patr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20229", "map_id": "Q20229", "name": "lsm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003076", "map_id": "WBGene00003076", "name": "lsm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620595", "map_id": "none", "name": "Decapped mRNA:LSM1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_430004", "map_id": "CHEBI:20794", "name": "7-MeGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620624", "map_id": "none", "name": "DCP1-DCP2 Decapping Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N363", "map_id": "Q9N363", "name": "dcap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021929", "map_id": "WBGene00021929", "name": "dcap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YF3", "map_id": "Q95YF3", "name": "cgh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000479", "map_id": "WBGene00000479", "name": "cgh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ITV6", "map_id": "Q8ITV6", "name": "edc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021551", "map_id": "WBGene00021551", "name": "edc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62255", "map_id": "O62255", "name": "dcap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003582", "map_id": "WBGene00003582", "name": "dcap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21740", "map_id": "Q21740", "name": "edc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011036", "map_id": "WBGene00011036", "name": "edc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604054", "map_id": "none", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604050", "map_id": "none", "name": "capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604052", "map_id": "none", "name": "CPSF:capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622686", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622645", "map_id": "Q20155", "name": "ccch-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622647", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604044", "map_id": "none", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604038", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20709", "map_id": "Q20709", "name": "tra-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018740", "map_id": "WBGene00018740", "name": "tra-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CKC3", "map_id": "V6CKC3", "name": "znf-236", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021689", "map_id": "WBGene00021689", "name": "znf-236", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYQ8", "map_id": "Q9GYQ8", "name": "LSM11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016791", "map_id": "WBGene00016791", "name": "LSM11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWY5", "map_id": "Q7YWY5", "name": "LSM10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010619", "map_id": "WBGene00010619", "name": "LSM10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604036", "map_id": "none", "name": "U7 snRNP:ZNF473", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622668", "map_id": "none", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10623677", "map_id": "none", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622653", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623675", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604761", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603997", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604755", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10610139", "map_id": "none", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610135", "map_id": "O17066", "name": "SNUPN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017746", "map_id": "WBGene00017746", "name": "SNUPN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610130", "map_id": "none", "name": "Spliceosomal m3G capped snRNAs with SMN:SM protein complex bound", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01871", "map_id": "O01871", "name": "GEMIN6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017002", "map_id": "WBGene00017002", "name": "GEMIN6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC16", "map_id": "G5EC16", "name": "smn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004887", "map_id": "WBGene00004887", "name": "smn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED26", "map_id": "G5ED26", "name": "mel-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020284", "map_id": "WBGene00020284", "name": "mel-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A7LPI7", "map_id": "A7LPI7", "name": "GEMIN7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007702", "map_id": "WBGene00007702", "name": "GEMIN7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:1604", "map_id": "CHEBI:1604", "name": "CHEBI:1604", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N405", "map_id": "Q9N405", "name": "smi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004886", "map_id": "WBGene00004886", "name": "smi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34399", "map_id": "P34399", "name": "GEMIN8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017357", "map_id": "WBGene00017357", "name": "GEMIN8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610137", "map_id": "none", "name": "Spliceosomal m3G capped snRNA:SMN:SM:Snurportin complex ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17066", "map_id": "O17066", "name": "SNUPN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603876", "map_id": "none", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603850", "map_id": "none", "name": "RNA Pol II with phosphorylated CTD: CE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17607", "map_id": "Q17607", "name": "cel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000466", "map_id": "WBGene00000466", "name": "cel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603872", "map_id": "Q21338", "name": "phospho-spt-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603866", "map_id": "Q9XVS1", "name": "tag-72", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006447", "map_id": "WBGene00006447", "name": "tag-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603874", "map_id": "none", "name": "CE:Pol II CTD:Spt5 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XVS1", "map_id": "Q9XVS1", "name": "tag-72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604070", "map_id": "none", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10622665", "map_id": "none", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620691", "map_id": "none", "name": "Exosome Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620605", "map_id": "Q9N363", "name": "dcap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620612", "map_id": "O62255", "name": "dcap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622661", "map_id": "Q9BHK7", "name": "xrn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012730", "map_id": "WBGene00012730", "name": "xrn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622663", "map_id": "none", "name": "BRF1:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BHK7", "map_id": "Q9BHK7", "name": "xrn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622656", "map_id": "none", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609568", "map_id": "none", "name": "Homologues of p-S272,T222,T334-MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604040", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604004", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603908", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10604006", "map_id": "none", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604002", "map_id": "Q09599", "name": "cdl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603901", "map_id": "none", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603894", "map_id": "none", "name": "Capping complex (GpppN..)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603899", "map_id": "none", "name": "Capping complex (with freed 5'- GMP)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10620637", "map_id": "none", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620591", "map_id": "none", "name": "Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625887", "map_id": "none", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625883", "map_id": "none", "name": "Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625863", "map_id": "O76512", "name": "smg-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625885", "map_id": "none", "name": "UPF1:eRF3 Complex on Translated mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622684", "map_id": "none", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10603897", "map_id": "none", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603889", "map_id": "none", "name": "Capping complex (intermediate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603892", "map_id": "none", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113571", "map_id": "CHEBI:37565", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603882", "map_id": "none", "name": "Capping complex (hydrolyzed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10610188", "map_id": "none", "name": "snRNP nuclear import and release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10610180", "map_id": "none", "name": "SMN complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10610186", "map_id": "none", "name": "Spliceosomal m3G capped snRNA loaded with the SM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603906", "map_id": "none", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10599965", "map_id": "none", "name": "RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601853", "map_id": "none", "name": "TFIIH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603903", "map_id": "none", "name": "mRNA capping factors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603856", "map_id": "none", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603848", "map_id": "Q17607", "name": "cel-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603854", "map_id": "none", "name": "Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604759", "map_id": "none", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10620635", "map_id": "none", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429925", "map_id": "none", "name": "oligoribonucleotide with a 5'-diphosphate", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620632", "map_id": "G5EFS4", "name": "dcs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000940", "map_id": "WBGene00000940", "name": "dcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603852", "map_id": "none", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10604066", "map_id": "none", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604064", "map_id": "none", "name": "upstream mRNA fragment:CPSF:PAP:PABPN1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_112165", "map_id": "none", "name": "downstream intronless mRNA fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603910", "map_id": "none", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10599967", "map_id": "none", "name": "capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603885", "map_id": "none", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603878", "map_id": "none", "name": "Capping complex (initial)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603880", "map_id": "none", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_72084", "map_id": "none", "name": "nascent pre-mRNA transcript", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29428", "map_id": "none", "name": "DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10610151", "map_id": "none", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610143", "map_id": "none", "name": "Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:2274", "map_id": "CHEBI:2274", "name": "CHEBI:2274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610148", "map_id": "Q94013", "name": "TGS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011631", "map_id": "WBGene00011631", "name": "TGS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604058", "map_id": "none", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10659874", "map_id": "none", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659871", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659858", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659867", "map_id": "none", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659864", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641084", "map_id": "none", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641071", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641081", "map_id": "none", "name": "p-TCF/LEF:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641067", "map_id": "none", "name": "pT298-NLK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U9Y8", "map_id": "Q9U9Y8", "name": "phospho-lit-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003048", "map_id": "WBGene00003048", "name": "phospho-lit-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641029", "map_id": "none", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641021", "map_id": "none", "name": "CAMK2:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10641016", "map_id": "none", "name": "p-T286 CAMK2:CaM", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10637600", "map_id": "none", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635196", "map_id": "none", "name": "Calcineurin (CaN)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0G819", "map_id": "Q0G819", "name": "tax-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006527", "map_id": "WBGene00006527", "name": "tax-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDN6", "map_id": "G5EDN6", "name": "cnb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000554", "map_id": "WBGene00000554", "name": "cnb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_912516", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10637574", "map_id": "none", "name": "Calcineurin:Calmodulin (CaN:CaM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10641019", "map_id": "none", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641014", "map_id": "none", "name": "p-T286,T305,T306-CAMK2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10641025", "map_id": "none", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620916", "map_id": "none", "name": "CaMKII dodecamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10641023", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641069", "map_id": "none", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641063", "map_id": "none", "name": "pT298-NLK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640879", "map_id": "none", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640874", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) active", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECQ2", "map_id": "G5ECQ2", "name": "cfz-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000478", "map_id": "WBGene00000478", "name": "cfz-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34889", "map_id": "P34889", "name": "cwn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000858", "map_id": "WBGene00000858", "name": "cwn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10459", "map_id": "Q10459", "name": "mom-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003395", "map_id": "WBGene00003395", "name": "mom-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P51875", "map_id": "P51875", "name": "goa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001648", "map_id": "WBGene00001648", "name": "goa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AWM6", "map_id": "A0A0K3AWM6", "name": "mom-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "T23D8.1b", "map_id": "T23D8.1b", "name": "mom-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27886", "map_id": "Q27886", "name": "lin-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003029", "map_id": "WBGene00003029", "name": "lin-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N532", "map_id": "Q9N532", "name": "mig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003238", "map_id": "WBGene00003238", "name": "mig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640857", "map_id": "none", "name": "WNT5A/11:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640864", "map_id": "none", "name": "G-protein alpha (o/t2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640877", "map_id": "none", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640870", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) inactive", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641175", "map_id": "none", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641169", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10641173", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603920", "map_id": "none", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77252", "map_id": "CHEBI:27668", "name": "(S)-3-Hydroxydodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77253", "map_id": "CHEBI:27868", "name": "3-Oxododecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10603917", "map_id": "none", "name": "HADH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P41938", "map_id": "P41938", "name": "HADH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007129", "map_id": "WBGene00007129", "name": "HADH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603922", "map_id": "none", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77255", "map_id": "CHEBI:15471", "name": "2-trans-Dodecenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599018", "map_id": "none", "name": "ECHS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34559", "map_id": "P34559", "name": "ech-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001155", "map_id": "WBGene00001155", "name": "ech-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603961", "map_id": "none", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113559", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10603934", "map_id": "none", "name": "Trifunctional Protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34255", "map_id": "P34255", "name": "HADHB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015125", "map_id": "WBGene00015125", "name": "HADHB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYT0", "map_id": "Q9GYT0", "name": "ech-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020347", "map_id": "WBGene00020347", "name": "ech-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613700", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10613697", "map_id": "H2KYS3", "name": "daf-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00000905", "map_id": "WBGene00000905", "name": "daf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662871", "map_id": "none", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10662869", "map_id": "none", "name": "CUBN:25(OH)D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_350136", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "Q93212", "map_id": "Q93212", "name": "sol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004944", "map_id": "WBGene00004944", "name": "sol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662867", "map_id": "Q93212", "name": "sol-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10662875", "map_id": "none", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8963912", "map_id": "CHEBI:17823", "name": "1,25(OH)2D", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10616155", "map_id": "none", "name": "Homologues of VDR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XYB7", "map_id": "Q9XYB7", "name": "nhr-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003607", "map_id": "WBGene00003607", "name": "nhr-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94407", "map_id": "Q94407", "name": "nhr-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003638", "map_id": "WBGene00003638", "name": "nhr-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFF5", "map_id": "G5EFF5", "name": "daf-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000908", "map_id": "WBGene00000908", "name": "daf-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662873", "map_id": "none", "name": "1,25(OH)2D:VDR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10629238", "map_id": "none", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629233", "map_id": "none", "name": "SHC1:Phosphorylated ERBB2 heterodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10629235", "map_id": "none", "name": "p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643411", "map_id": "none", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358610", "map_id": "none", "name": "DNA containing single strand nick (5' phosphate, 3' hydroxyl)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_109966", "map_id": "none", "name": "Repaired double-stranded DNA", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10636603", "map_id": "none", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636599", "map_id": "none", "name": "FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q21882", "map_id": "Q21882", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022808", "map_id": "WBGene00022808", "name": "TTR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44578", "map_id": "O44578", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636601", "map_id": "none", "name": "HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10614244", "map_id": "none", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211892", "map_id": "CHEBI:7772", "name": "Losec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_211944", "map_id": "CHEBI:63840", "name": "HOMZ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614239", "map_id": "none", "name": "Cytochrome P450 (CYP2C8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10614257", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614254", "map_id": "none", "name": "Cytochrome P450 (CYP2W1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603732", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76328", "map_id": "CHEBI:28794", "name": "COUM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76452", "map_id": "CHEBI:27510", "name": "HCOU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10603729", "map_id": "none", "name": "Cytochrome P450 (CYP2A3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10614249", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614246", "map_id": "H2KYS3", "name": "daf-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10650224", "map_id": "none", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6786220", "map_id": "CHEBI:36005", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6786225", "map_id": "CHEBI:72790", "name": "hydroxydocosahexaenoic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10650221", "map_id": "G5EC97", "name": "cyp-29a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00011830", "map_id": "WBGene00011830", "name": "cyp-29a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614237", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10614234", "map_id": "none", "name": "Cytochrome P450 (CYP2A13 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10614264", "map_id": "none", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211855", "map_id": "CHEBI:27999", "name": "TBM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211937", "map_id": "CHEBI:63799", "name": "HTOLB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10614262", "map_id": "none", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215062", "map_id": "none", "name": "cis-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10614259", "map_id": "none", "name": "Cytochrome P450 (CYP2J2 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10610411", "map_id": "none", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10610408", "map_id": "none", "name": "Homologues of CYP19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O45219", "map_id": "O45219", "name": "cyp-29a4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007140", "map_id": "WBGene00007140", "name": "cyp-29a4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1R5", "map_id": "Q9U1R5", "name": "cyp-42a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013585", "map_id": "WBGene00013585", "name": "cyp-42a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17851", "map_id": "O17851", "name": "cyp-37b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009226", "map_id": "WBGene00009226", "name": "cyp-37b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N525", "map_id": "Q9N525", "name": "cyp-29a3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021412", "map_id": "WBGene00021412", "name": "cyp-29a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVA6", "map_id": "Q9XVA6", "name": "cyp-37a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008499", "map_id": "WBGene00008499", "name": "cyp-37a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4Q5", "map_id": "Q9N4Q5", "name": "cyp-32b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021167", "map_id": "WBGene00021167", "name": "cyp-32b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGT6", "map_id": "G5EGT6", "name": "cyp-31a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010354", "map_id": "WBGene00010354", "name": "cyp-31a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27472", "map_id": "Q27472", "name": "cyp-32a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016147", "map_id": "WBGene00016147", "name": "cyp-32a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N574", "map_id": "Q9N574", "name": "cyp-31a3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021200", "map_id": "WBGene00021200", "name": "cyp-31a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC97", "map_id": "G5EC97", "name": "cyp-29a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603727", "map_id": "none", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40887", "map_id": "CHEBI:27385", "name": "CCl4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76433", "map_id": "none", "name": "Trichloromethyl radical", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29572", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10603718", "map_id": "none", "name": "Cytochrome P450 (CYP2E1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603819", "map_id": "none", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40795", "map_id": "CHEBI:5615", "name": "HALO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76473", "map_id": "CHEBI:29138", "name": "TFAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76474", "map_id": "CHEBI:47266", "name": "HBr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10614232", "map_id": "none", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215573", "map_id": "CHEBI:15367", "name": "atRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_215584", "map_id": "CHEBI:63795", "name": "4OH-atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10603636", "map_id": "none", "name": "Homologues of CYP2S1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603721", "map_id": "none", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_39417", "map_id": "CHEBI:28509", "name": "VC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156524", "map_id": "CHEBI:29129", "name": "2CEO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10605850", "map_id": "none", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113748", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113745", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10603725", "map_id": "none", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_31711", "map_id": "CHEBI:16716", "name": "C6H6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29630", "map_id": "CHEBI:15882", "name": "PhOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10614269", "map_id": "none", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211977", "map_id": "CHEBI:4026", "name": "CPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211967", "map_id": "CHEBI:1864", "name": "HCPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614266", "map_id": "none", "name": "Cytochrome P450 (CYP2B6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603723", "map_id": "none", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113555", "map_id": "CHEBI:18276", "name": "H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_39427", "map_id": "CHEBI:46195", "name": "Acetaminophen (TN TYLENOL)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10614252", "map_id": "none", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211993", "map_id": "CHEBI:34665", "name": "DSQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211952", "map_id": "CHEBI:63800", "name": "HDBQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10603814", "map_id": "none", "name": "Cytochrome P450 (CYP2D6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10614242", "map_id": "none", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211906", "map_id": "CHEBI:45863", "name": "PTXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211894", "map_id": "CHEBI:63859", "name": "HPTXL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10614276", "map_id": "none", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_213162", "map_id": "CHEBI:9171", "name": "MIND", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_213163", "map_id": "CHEBI:63905", "name": "3MEIN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10614274", "map_id": "none", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211939", "map_id": "CHEBI:8107", "name": "Phenytoin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211927", "map_id": "CHEBI:63804", "name": "HPHT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614271", "map_id": "none", "name": "Cytochrome P450 (CYP2C18 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603817", "map_id": "none", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_39703", "map_id": "LigandDisplayForward?ligandId=6953", "name": "DEXM", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76455", "map_id": "LigandDisplayForward?ligandId=9052", "name": "DEXT", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10637598", "map_id": "none", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637578", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10637596", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638009", "map_id": "none", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602448", "map_id": "none", "name": "Homologues of RBP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01814", "map_id": "O01814", "name": "lbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002257", "map_id": "WBGene00002257", "name": "lbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02323", "map_id": "O02323", "name": "lbp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002259", "map_id": "WBGene00002259", "name": "lbp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01812", "map_id": "O01812", "name": "lbp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002258", "map_id": "WBGene00002258", "name": "lbp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02324", "map_id": "O02324", "name": "lbp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002260", "map_id": "WBGene00002260", "name": "lbp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965W1", "map_id": "Q965W1", "name": "lbp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021486", "map_id": "WBGene00021486", "name": "lbp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2473610", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636648", "map_id": "none", "name": "RBP1:atROL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5623649", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10626966", "map_id": "none", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975643", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626963", "map_id": "none", "name": "BCMO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2E4", "map_id": "Q9U2E4", "name": "bcmo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012914", "map_id": "WBGene00012914", "name": "bcmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602452", "map_id": "none", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473604", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602450", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10637084", "map_id": "none", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602105", "map_id": "none", "name": "cGMP:CNG channel", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03611", "map_id": "Q03611", "name": "tax-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006526", "map_id": "WBGene00006526", "name": "tax-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61827", "map_id": "O61827", "name": "che-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000487", "map_id": "WBGene00000487", "name": "che-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z205", "map_id": "Q7Z205", "name": "cng-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000563", "map_id": "WBGene00000563", "name": "cng-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE2", "map_id": "G5EEE2", "name": "tax-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006525", "map_id": "WBGene00006525", "name": "tax-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8WI01", "map_id": "A8WI01", "name": "cng-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000562", "map_id": "WBGene00000562", "name": "cng-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30991", "map_id": "CHEBI:16356", "name": "cGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q9N4C1", "map_id": "Q9N4C1", "name": "cng-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022295", "map_id": "WBGene00022295", "name": "cng-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636806", "map_id": "none", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473607", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636803", "map_id": "none", "name": "Homologues of DHRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74000", "compartment_display": "photoreceptor outer segment membrane", "complex": "true" }, { "id": "Q22392", "map_id": "Q22392", "name": "dhs-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000982", "map_id": "WBGene00000982", "name": "dhs-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYX5", "map_id": "A5JYX5", "name": "dhs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000967", "map_id": "WBGene00000967", "name": "dhs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18030", "map_id": "O18030", "name": "dhs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000968", "map_id": "WBGene00000968", "name": "dhs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19843", "map_id": "Q19843", "name": "dhs-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000992", "map_id": "WBGene00000992", "name": "dhs-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637063", "map_id": "none", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10637061", "map_id": "none", "name": "Gt-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10637052", "map_id": "none", "name": "GNAT1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10637059", "map_id": "none", "name": "GNB1:GNGT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10602107", "map_id": "none", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602103", "map_id": "none", "name": "CNG channel", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637131", "map_id": "none", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10637121", "map_id": "P54406", "name": "gpc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_2530486", "map_id": "CHEBI:50277", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10637057", "map_id": "P54406", "name": "gpc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_10637128", "map_id": "none", "name": "FNTA:FNTB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19752", "map_id": "Q19752", "name": "fntb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006465", "map_id": "WBGene00006465", "name": "fntb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44501", "map_id": "O44501", "name": "fnta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019823", "map_id": "WBGene00019823", "name": "fnta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626938", "map_id": "none", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_975591", "map_id": "CHEBI:17616", "name": "RPALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_426576", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_975590", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10626935", "map_id": "Q9N2Z4", "name": "PLB1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00022040", "map_id": "WBGene00022040", "name": "PLB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637150", "map_id": "none", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637140", "map_id": "none", "name": "Homologues of GNAT1 (Met removed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2534019", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10637048", "map_id": "none", "name": "Homologues of N-(C14:0)-GNAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10637145", "map_id": "P46548", "name": "nmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020549", "map_id": "WBGene00020549", "name": "nmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642008", "map_id": "none", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5164389", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164390", "map_id": "CHEBI:32325", "name": "bION", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164383", "map_id": "CHEBI:53153", "name": "APO10al", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10642005", "map_id": "none", "name": "BCO2:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9TXT9", "map_id": "Q9TXT9", "name": "bcmo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018755", "map_id": "WBGene00018755", "name": "bcmo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L060", "map_id": "H2L060", "name": "BCO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018640", "map_id": "WBGene00018640", "name": "BCO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637081", "map_id": "none", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10638007", "map_id": "none", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626954", "map_id": "none", "name": "RBP2:atRAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5623648", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10626952", "map_id": "none", "name": "RBP2:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638004", "map_id": "none", "name": "AKRs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91020", "map_id": "P91020", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016985", "map_id": "WBGene00016985", "name": "AKR1B10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18903", "map_id": "Q18903", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2J5", "map_id": "Q9U2J5", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAI5", "map_id": "Q9NAI5", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23320", "map_id": "Q23320", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22352", "map_id": "Q22352", "name": "exc-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020369", "map_id": "WBGene00020369", "name": "exc-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637175", "map_id": "none", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637156", "map_id": "none", "name": "Homologues of GNAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10637172", "map_id": "none", "name": "METAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965Y1", "map_id": "Q965Y1", "name": "map-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003129", "map_id": "WBGene00003129", "name": "map-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_880069", "map_id": "CHEBI:27638", "name": "Co2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "H1UBK1", "map_id": "H1UBK1", "name": "map-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003130", "map_id": "WBGene00003130", "name": "map-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636780", "map_id": "none", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2864099", "map_id": "none", "name": "atREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:70761", "map_id": "CHEBI:70761", "name": "CHEBI:70761", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70760", "map_id": "CHEBI:70760", "name": "CHEBI:70760", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70762", "map_id": "CHEBI:70762", "name": "CHEBI:70762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2864103", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_2046044", "map_id": "CHEBI:17351", "name": "LINA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_30927", "map_id": "CHEBI:16302", "name": "11cROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636772", "map_id": "none", "name": "Homologues of RPE65", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10636778", "map_id": "P91443", "name": "hum-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002039", "map_id": "WBGene00002039", "name": "hum-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636650", "map_id": "none", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473616", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10638750", "map_id": "none", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638748", "map_id": "none", "name": "CALM1:Ca2+:CNG channel", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636642", "map_id": "none", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636634", "map_id": "G5EEB8", "name": "lpr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00011726", "map_id": "WBGene00011726", "name": "lpr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2395761", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10636636", "map_id": "none", "name": "RBP4:atROL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EEB8", "map_id": "G5EEB8", "name": "lpr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636646", "map_id": "none", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636644", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10637319", "map_id": "none", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637309", "map_id": "none", "name": "GUCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10637317", "map_id": "none", "name": "GUCA:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10636629", "map_id": "none", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626950", "map_id": "none", "name": "Homologues of RBP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626956", "map_id": "none", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10636640", "map_id": "none", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636597", "map_id": "none", "name": "Transthyretin tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10636638", "map_id": "none", "name": "TTR:RBP4:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10636485", "map_id": "none", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636483", "map_id": "none", "name": "Phosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09591", "map_id": "Q09591", "name": "mix-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003367", "map_id": "WBGene00003367", "name": "mix-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34341", "map_id": "P34341", "name": "phospho-kle-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016202", "map_id": "WBGene00016202", "name": "phospho-kle-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20060", "map_id": "Q20060", "name": "smc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004874", "map_id": "WBGene00004874", "name": "smc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20818", "map_id": "Q20818", "name": "phospho-capg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010093", "map_id": "WBGene00010093", "name": "phospho-capg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y84", "map_id": "Q95Y84", "name": "phospho-hcp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001833", "map_id": "WBGene00001833", "name": "phospho-hcp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605870", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004043", "map_id": "WBGene00004043", "name": "phospho-plk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636465", "map_id": "none", "name": "p-T210-PLK1:Phosphorylated Condensin II:Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N2L7", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636457", "map_id": "none", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636172", "map_id": "none", "name": "Condensin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636183", "map_id": "none", "name": "Nucleosome with H3K4me2/3:H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636455", "map_id": "none", "name": "Condensin II:Nucleosome with H4K20me1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636174", "map_id": "none", "name": "Condensin II:RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636453", "map_id": "none", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636196", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3:H4K20me1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10636451", "map_id": "none", "name": "p-2S-PHF8:Fe2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636176", "map_id": "none", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10636495", "map_id": "none", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636200", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636435", "map_id": "none", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10636427", "map_id": "none", "name": "p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10636432", "map_id": "none", "name": "p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10636487", "map_id": "none", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10636696", "map_id": "none", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10636677", "map_id": "none", "name": "GORASP2:BLZF1:RAB2A:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q21954", "map_id": "Q21954", "name": "BLZF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020018", "map_id": "WBGene00020018", "name": "BLZF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C2Y0", "map_id": "A0A2C9C2Y0", "name": "unc-108", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006833", "map_id": "WBGene00006833", "name": "unc-108", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636683", "map_id": "none", "name": "p-T222,225-GORASP2:BLZF1:RAB2A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10636693", "map_id": "none", "name": "p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636481", "map_id": "none", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636478", "map_id": "none", "name": "Hyperphosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10636203", "map_id": "none", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10611278", "map_id": "none", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611266", "map_id": "none", "name": "Homologues of RPS6KB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21694", "map_id": "Q21694", "name": "phospho-p-S15,S356-RPS6KB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044281", "map_id": "WBGene00044281", "name": "phospho-p-S15,S356-RPS6KB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAH6", "map_id": "Q9NAH6", "name": "phospho-rsks-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012929", "map_id": "WBGene00012929", "name": "phospho-rsks-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611276", "map_id": "none", "name": "Homologues of p-S15,S356-RPS6KB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611288", "map_id": "none", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611283", "map_id": "P41829", "name": "nhr-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003605", "map_id": "WBGene00003605", "name": "phospho-nhr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611286", "map_id": "P41829", "name": "phospho-nhr-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611197", "map_id": "none", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611171", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611182", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611166", "map_id": "none", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10664163", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664160", "map_id": "none", "name": "CYP1A2,2C8,2C9,2D6,2E1,3A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10664166", "map_id": "none", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027029", "map_id": "CHEBI:137347", "name": "14(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027326", "map_id": "none", "name": "14(S),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137360", "map_id": "CHEBI:137360", "name": "CHEBI:137360", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137354", "map_id": "CHEBI:137354", "name": "CHEBI:137354", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603316", "map_id": "none", "name": "Homologues of CYP2E1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10664168", "map_id": "none", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027324", "map_id": "none", "name": "14(R),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137368", "map_id": "CHEBI:137368", "name": "CHEBI:137368", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137361", "map_id": "CHEBI:137361", "name": "CHEBI:137361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620391", "map_id": "none", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620389", "map_id": "none", "name": "Homologues of MAPK14", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10609584", "map_id": "none", "name": "Homologues of p-T180,Y182-MAPK14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618931", "map_id": "none", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615234", "map_id": "G5EE56", "name": "phospho-src-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648796", "map_id": "none", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607380", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607378", "map_id": "P0CG71", "name": "ubq-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597913", "map_id": "O76577", "name": "rpn-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648793", "map_id": "none", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648788", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N3S7", "map_id": "Q9N3S7", "name": "pcaf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021636", "map_id": "WBGene00021636", "name": "pcaf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34545", "map_id": "P34545", "name": "cbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648790", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607397", "map_id": "none", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10607392", "map_id": "none", "name": "ETF:FAD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9TXI4", "map_id": "Q9TXI4", "name": "Me3K200,Me3K203-ETFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017734", "map_id": "WBGene00017734", "name": "Me3K200,Me3K203-ETFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93615", "map_id": "Q93615", "name": "Q93615", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009187", "map_id": "WBGene00009187", "name": "Q93615", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10607394", "map_id": "none", "name": "ETF:FADH2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10607405", "map_id": "none", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73663", "map_id": "CHEBI:46245", "name": "CoQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_76633", "map_id": "CHEBI:17976", "name": "QH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10607402", "map_id": "Q11190", "name": "let-721", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00002855", "map_id": "WBGene00002855", "name": "let-721", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10654352", "map_id": "none", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10654304", "map_id": "none", "name": "HP subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9BL33", "map_id": "Q9BL33", "name": "NDUFC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022169", "map_id": "WBGene00022169", "name": "NDUFC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44509", "map_id": "O44509", "name": "NDUFB11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018361", "map_id": "WBGene00018361", "name": "NDUFB11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U241", "map_id": "Q9U241", "name": "NDUFAB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013237", "map_id": "WBGene00013237", "name": "NDUFAB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44955", "map_id": "O44955", "name": "NDUFA13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016393", "map_id": "WBGene00016393", "name": "NDUFA13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93831", "map_id": "Q93831", "name": "NDUFB10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010326", "map_id": "WBGene00010326", "name": "NDUFB10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18236", "map_id": "O18236", "name": "nuo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013308", "map_id": "WBGene00013308", "name": "nuo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23098", "map_id": "Q23098", "name": "nuo-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012166", "map_id": "WBGene00012166", "name": "nuo-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90789", "map_id": "P90789", "name": "NDUFB7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008414", "map_id": "WBGene00008414", "name": "NDUFB7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02267", "map_id": "O02267", "name": "NDUFA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009740", "map_id": "WBGene00009740", "name": "NDUFA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18359", "map_id": "Q18359", "name": "NDUFA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007880", "map_id": "WBGene00007880", "name": "NDUFA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYV1", "map_id": "H2KYV1", "name": "NDUFB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016118", "map_id": "WBGene00016118", "name": "NDUFB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL03", "map_id": "Q9BL03", "name": "NDUFA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021849", "map_id": "WBGene00021849", "name": "NDUFA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18095", "map_id": "Q18095", "name": "NDUFB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007684", "map_id": "WBGene00007684", "name": "NDUFB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWG2", "map_id": "Q9XWG2", "name": "NDUFA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013406", "map_id": "WBGene00013406", "name": "NDUFA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18036", "map_id": "Q18036", "name": "NDUFB9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015810", "map_id": "WBGene00015810", "name": "NDUFB9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21233", "map_id": "Q21233", "name": "nuo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019401", "map_id": "WBGene00019401", "name": "nuo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20412", "map_id": "Q20412", "name": "NDUFB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009712", "map_id": "WBGene00009712", "name": "NDUFB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10654348", "map_id": "none", "name": "Intermediate 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9N3H3", "map_id": "Q9N3H3", "name": "nduf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021800", "map_id": "WBGene00021800", "name": "nduf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "I2HAE1", "map_id": "I2HAE1", "name": "TIMMDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021421", "map_id": "WBGene00021421", "name": "TIMMDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93931", "map_id": "Q93931", "name": "nuaf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011123", "map_id": "WBGene00011123", "name": "nuaf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22619", "map_id": "Q22619", "name": "NDUFS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020636", "map_id": "WBGene00020636", "name": "NDUFS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93873", "map_id": "Q93873", "name": "gas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001520", "map_id": "WBGene00001520", "name": "gas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NC2", "map_id": "Q86NC2", "name": "nuo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020417", "map_id": "WBGene00020417", "name": "nuo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09644", "map_id": "Q09644", "name": "NDUFAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014227", "map_id": "WBGene00014227", "name": "NDUFAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17439", "map_id": "Q17439", "name": "NDUFAF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007113", "map_id": "WBGene00007113", "name": "NDUFAF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94360", "map_id": "Q94360", "name": "nduf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012376", "map_id": "WBGene00012376", "name": "nduf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10654350", "map_id": "none", "name": "Intermediate 2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10654384", "map_id": "none", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10654336", "map_id": "Q93931", "name": "nuaf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10654346", "map_id": "I2HAE1", "name": "TIMMDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10654331", "map_id": "none", "name": "IP subcomplex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10654341", "map_id": "Q17439", "name": "NDUFAF4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10655491", "map_id": "none", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10654329", "map_id": "Q86NC2", "name": "nuo-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10654320", "map_id": "none", "name": "NDUFA9:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10654324", "map_id": "none", "name": "NDUFS8:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10654322", "map_id": "none", "name": "NDUFS7:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10654313", "map_id": "none", "name": "NDUFAF7:NDUFS2:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10635778", "map_id": "none", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635776", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16720", "map_id": "O16720", "name": "alg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000106", "map_id": "WBGene00000106", "name": "alg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N585", "map_id": "Q9N585", "name": "ppw-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004094", "map_id": "WBGene00004094", "name": "ppw-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61931", "map_id": "O61931", "name": "ergo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019971", "map_id": "WBGene00019971", "name": "ergo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED77", "map_id": "G5ED77", "name": "alg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011910", "map_id": "WBGene00011910", "name": "alg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62275", "map_id": "O62275", "name": "wago-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010263", "map_id": "WBGene00010263", "name": "wago-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0U1RML5", "map_id": "A0A0U1RML5", "name": "sago-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018921", "map_id": "WBGene00018921", "name": "sago-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21770", "map_id": "Q21770", "name": "wago-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBF5", "map_id": "G5EBF5", "name": "rde-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004326", "map_id": "WBGene00004326", "name": "rde-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXN7", "map_id": "Q9TXN7", "name": "wago-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020707", "map_id": "WBGene00020707", "name": "wago-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34681", "map_id": "P34681", "name": "tag-76", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006449", "map_id": "WBGene00006449", "name": "tag-76", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614163", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10614183", "map_id": "none", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614181", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (miRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660554", "map_id": "none", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10607390", "map_id": "Q9TXI4", "name": "ETFB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10660546", "map_id": "Q9TXI4", "name": "Me3K200,Me3K203-ETFB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10660551", "map_id": "O01503", "name": "ETFBKMT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00016492", "map_id": "WBGene00016492", "name": "ETFBKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660627", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660619", "map_id": "P53013", "name": "eft-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660624", "map_id": "Q9GYH9", "name": "METTL10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017919", "map_id": "WBGene00017919", "name": "METTL10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660565", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660557", "map_id": "P53013", "name": "eft-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660562", "map_id": "Q5WRN3", "name": "N6AMT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00043057", "map_id": "WBGene00043057", "name": "N6AMT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660587", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643036", "map_id": "P54812", "name": "cdc-48.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660579", "map_id": "P54812", "name": "cdc-48.2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660584", "map_id": "A7IQW5", "name": "VCPKMT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016591", "map_id": "WBGene00016591", "name": "VCPKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620234", "map_id": "none", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620230", "map_id": "G5EF96", "name": "unc-40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10620228", "map_id": "none", "name": "Homologues of ROBO3.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620232", "map_id": "none", "name": "ROBO2,(ROBO1):ROBO3.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EF96", "map_id": "G5EF96", "name": "unc-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "unc-40", "map_id": "unc-40", "name": "unc-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661405", "map_id": "none", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10634735", "map_id": "none", "name": "Alpha-1(XXVII) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q09457", "map_id": "Q09457", "name": "bli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000251", "map_id": "WBGene00000251", "name": "bli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62432", "map_id": "O62432", "name": "dpy-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001066", "map_id": "WBGene00001066", "name": "dpy-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634737", "map_id": "none", "name": "C-linked procollagen type XXVII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10608764", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608761", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608706", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608753", "map_id": "none", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608746", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608750", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658941", "map_id": "none", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658936", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BI71", "map_id": "Q9BI71", "name": "epn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001329", "map_id": "WBGene00001329", "name": "epn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6A573", "map_id": "Q6A573", "name": "cdap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021549", "map_id": "WBGene00021549", "name": "cdap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIF4", "map_id": "Q9BIF4", "name": "phospho-ehs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001224", "map_id": "WBGene00001224", "name": "phospho-ehs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658938", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658951", "map_id": "none", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658948", "map_id": "P28191", "name": "ptp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004213", "map_id": "WBGene00004213", "name": "ptp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608704", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608631", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608701", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608735", "map_id": "none", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608731", "map_id": "none", "name": "Beta-Pix:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608708", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608733", "map_id": "none", "name": "EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608775", "map_id": "none", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608770", "map_id": "none", "name": "EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608772", "map_id": "none", "name": "Ub-Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608757", "map_id": "none", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608755", "map_id": "none", "name": "CBL:GRB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608779", "map_id": "none", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608777", "map_id": "none", "name": "CBL:Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608742", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608739", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608768", "map_id": "none", "name": "EGFR non-clathrin mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608660", "map_id": "Q9BIF4", "name": "ehs-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10608683", "map_id": "none", "name": "CIN85:endophilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608658", "map_id": "none", "name": "EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608639", "map_id": "Q9BI71", "name": "epn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10608685", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608710", "map_id": "none", "name": "Assembly of EGFR complex in clathrin-coated vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10608634", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608626", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608766", "map_id": "none", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608528", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608759", "map_id": "none", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10608699", "map_id": "none", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608696", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658943", "map_id": "none", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10661673", "map_id": "none", "name": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10664920", "map_id": "none", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9614913", "map_id": "none", "name": "ACEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6576", "map_id": "LigandDisplayForward?ligandId=6576", "name": "LigandDisplayForward?ligandId=6576", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6352", "map_id": "LigandDisplayForward?ligandId=6352", "name": "LigandDisplayForward?ligandId=6352", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6360", "map_id": "LigandDisplayForward?ligandId=6360", "name": "LigandDisplayForward?ligandId=6360", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:5488746", "map_id": "pubchem.compound:5488746", "name": "pubchem.compound:5488746", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6375", "map_id": "LigandDisplayForward?ligandId=6375", "name": "LigandDisplayForward?ligandId=6375", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5158", "map_id": "LigandDisplayForward?ligandId=5158", "name": "LigandDisplayForward?ligandId=5158", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6373", "map_id": "LigandDisplayForward?ligandId=6373", "name": "LigandDisplayForward?ligandId=6373", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6457", "map_id": "LigandDisplayForward?ligandId=6457", "name": "LigandDisplayForward?ligandId=6457", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6378", "map_id": "LigandDisplayForward?ligandId=6378", "name": "LigandDisplayForward?ligandId=6378", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:443151", "map_id": "pubchem.compound:443151", "name": "pubchem.compound:443151", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6572", "map_id": "LigandDisplayForward?ligandId=6572", "name": "LigandDisplayForward?ligandId=6572", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6463", "map_id": "LigandDisplayForward?ligandId=6463", "name": "LigandDisplayForward?ligandId=6463", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6455", "map_id": "LigandDisplayForward?ligandId=6455", "name": "LigandDisplayForward?ligandId=6455", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6332", "map_id": "LigandDisplayForward?ligandId=6332", "name": "LigandDisplayForward?ligandId=6332", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6461", "map_id": "LigandDisplayForward?ligandId=6461", "name": "LigandDisplayForward?ligandId=6461", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6344", "map_id": "LigandDisplayForward?ligandId=6344", "name": "LigandDisplayForward?ligandId=6344", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664916", "map_id": "Q18581", "name": "acn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00000039", "map_id": "WBGene00000039", "name": "acn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664918", "map_id": "none", "name": "ACEIs:ACE(30-1232)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18581", "map_id": "Q18581", "name": "acn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664965", "map_id": "none", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9619052", "map_id": "none", "name": "ACEI pro-drugs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6571", "map_id": "LigandDisplayForward?ligandId=6571", "name": "LigandDisplayForward?ligandId=6571", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6453", "map_id": "LigandDisplayForward?ligandId=6453", "name": "LigandDisplayForward?ligandId=6453", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6459", "map_id": "LigandDisplayForward?ligandId=6459", "name": "LigandDisplayForward?ligandId=6459", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6462", "map_id": "LigandDisplayForward?ligandId=6462", "name": "LigandDisplayForward?ligandId=6462", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6322", "map_id": "LigandDisplayForward?ligandId=6322", "name": "LigandDisplayForward?ligandId=6322", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:443874", "map_id": "pubchem.compound:443874", "name": "pubchem.compound:443874", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6575", "map_id": "LigandDisplayForward?ligandId=6575", "name": "LigandDisplayForward?ligandId=6575", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6456", "map_id": "LigandDisplayForward?ligandId=6456", "name": "LigandDisplayForward?ligandId=6456", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6374", "map_id": "LigandDisplayForward?ligandId=6374", "name": "LigandDisplayForward?ligandId=6374", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6350", "map_id": "LigandDisplayForward?ligandId=6350", "name": "LigandDisplayForward?ligandId=6350", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6377", "map_id": "LigandDisplayForward?ligandId=6377", "name": "LigandDisplayForward?ligandId=6377", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6339", "map_id": "LigandDisplayForward?ligandId=6339", "name": "LigandDisplayForward?ligandId=6339", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6367", "map_id": "LigandDisplayForward?ligandId=6367", "name": "LigandDisplayForward?ligandId=6367", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8878776", "map_id": "CHEBI:30879", "name": "Alcohol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9619021", "map_id": "none", "name": "hydrolysed ACEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10648914", "map_id": "none", "name": "CES1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0A1C3NSL8", "map_id": "A0A1C3NSL8", "name": "cest-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017478", "map_id": "WBGene00017478", "name": "cest-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641650", "map_id": "none", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641629", "map_id": "none", "name": "NR1H4:chenodeoxycholate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10641648", "map_id": "none", "name": "2SUMO1:NR1H4:chenodeoxycholate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604599", "map_id": "none", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604596", "map_id": "none", "name": "UNG-1:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604615", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604612", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604629", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604626", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604592", "map_id": "none", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604585", "map_id": "none", "name": "UNG-1:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604718", "map_id": "none", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604715", "map_id": "none", "name": "APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646034", "map_id": "none", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646032", "map_id": "none", "name": "APEX1:SSB(5'-ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604608", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604603", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604622", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604619", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603043", "map_id": "none", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76112", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10603038", "map_id": "Q22949", "name": "acl-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00017261", "map_id": "WBGene00017261", "name": "acl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649471", "map_id": "none", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696122", "map_id": "CHEBI:52575", "name": "alkylglycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10649468", "map_id": "O17554", "name": "agmo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007210", "map_id": "WBGene00007210", "name": "agmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623982", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623979", "map_id": "none", "name": "Homologues of DGAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XUW0", "map_id": "Q9XUW0", "name": "dgat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010296", "map_id": "WBGene00010296", "name": "dgat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01881", "map_id": "O01881", "name": "AWAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021818", "map_id": "WBGene00021818", "name": "AWAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4S3", "map_id": "Q9N4S3", "name": "AWAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23067", "map_id": "Q23067", "name": "dgtr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020910", "map_id": "WBGene00020910", "name": "dgtr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10654790", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10654787", "map_id": "none", "name": "MOGAT1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10603094", "map_id": "none", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603087", "map_id": "Q9XXT5", "name": "lpin-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10603055", "map_id": "none", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603052", "map_id": "none", "name": "GK,GK2,GK3P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21944", "map_id": "Q21944", "name": "GK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020007", "map_id": "WBGene00020007", "name": "GK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603104", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603101", "map_id": "none", "name": "DGAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NCE1", "map_id": "Q9NCE1", "name": "mboa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010408", "map_id": "WBGene00010408", "name": "mboa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620748", "map_id": "none", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620739", "map_id": "Q09497", "name": "rsu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007924", "map_id": "WBGene00007924", "name": "rsu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620744", "map_id": "P50464", "name": "unc-97", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006826", "map_id": "WBGene00006826", "name": "unc-97", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620746", "map_id": "none", "name": "Rsu-1:Pinch1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P50464", "map_id": "P50464", "name": "unc-97", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09497", "map_id": "Q09497", "name": "rsu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622178", "map_id": "none", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622174", "map_id": "O16785", "name": "pat-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003932", "map_id": "WBGene00003932", "name": "pat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608499", "map_id": "Q09476", "name": "pxl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00016197", "map_id": "WBGene00016197", "name": "phospho-pxl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622176", "map_id": "none", "name": "PARVA:Paxillin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16785", "map_id": "O16785", "name": "pat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09476", "map_id": "Q09476", "name": "phospho-pxl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620734", "map_id": "none", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620725", "map_id": "Q23158", "name": "atn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620730", "map_id": "O16785", "name": "pat-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620732", "map_id": "none", "name": "PARVB:alpha actinin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621028", "map_id": "none", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621026", "map_id": "none", "name": "ParvB/Affixin:Alpha-Pix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608576", "map_id": "none", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608532", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608574", "map_id": "none", "name": "EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608461", "map_id": "none", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604177", "map_id": "G5EDJ4", "name": "soc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608619", "map_id": "none", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608549", "map_id": "none", "name": "GRB2:GAB1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608535", "map_id": "none", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608497", "map_id": "none", "name": "p-Y-PXN:CSK:MyrG,p-Y530-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608503", "map_id": "none", "name": "PXN:MyrG-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608482", "map_id": "G5ECJ6", "name": "csk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10608547", "map_id": "none", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608545", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608597", "map_id": "none", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608594", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608599", "map_id": "none", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608551", "map_id": "none", "name": "GRB2:GAB1,GRB2:GAB1:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608553", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:GAB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608559", "map_id": "none", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608530", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617088", "map_id": "none", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10617085", "map_id": "none", "name": "Docked serotonin loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19136", "map_id": "Q19136", "name": "sue-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006306", "map_id": "WBGene00006306", "name": "sue-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34693", "map_id": "P34693", "name": "snt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004921", "map_id": "WBGene00004921", "name": "snt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27715", "map_id": "P27715", "name": "unc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006752", "map_id": "WBGene00006752", "name": "unc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXU3", "map_id": "Q8MXU3", "name": "snn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004913", "map_id": "WBGene00004913", "name": "snn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GUM7", "map_id": "Q9GUM7", "name": "cpx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022271", "map_id": "WBGene00022271", "name": "cpx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GNP0", "map_id": "Q9GNP0", "name": "cat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000295", "map_id": "WBGene00000295", "name": "cat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N415", "map_id": "Q9N415", "name": "rimb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006513", "map_id": "WBGene00006513", "name": "rimb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S5", "map_id": "Q965S5", "name": "snt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004923", "map_id": "WBGene00004923", "name": "snt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8FE10", "map_id": "K8FE10", "name": "snt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004922", "map_id": "WBGene00004922", "name": "snt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16700", "map_id": "O16700", "name": "snt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004925", "map_id": "WBGene00004925", "name": "snt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22366", "map_id": "Q22366", "name": "unc-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006750", "map_id": "WBGene00006750", "name": "unc-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94986", "map_id": "Q94986", "name": "rab-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004267", "map_id": "WBGene00004267", "name": "rab-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614130", "map_id": "none", "name": "Homologues of SYT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614132", "map_id": "Q94986", "name": "rab-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10617004", "map_id": "none", "name": "Synapsin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "species_10614086", "map_id": "none", "name": "RIMS1:UNC13B:BZRAP1:Alpha-liprin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613945", "map_id": "P34815", "name": "unc-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614116", "map_id": "none", "name": "SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614053", "map_id": "Q9GUM7", "name": "cpx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615845", "map_id": "Q9GNP0", "name": "cat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10617033", "map_id": "none", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_380585", "map_id": "CHEBI:28790", "name": "5HT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "false" }, { "id": "species_10615376", "map_id": "Q9GNP0", "name": "cat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10617091", "map_id": "none", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617083", "map_id": "none", "name": "Serotonin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "species_10614048", "map_id": "none", "name": "Homologues of SNAP25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619748", "map_id": "none", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426219", "map_id": "none", "name": "Cations", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_426221", "map_id": "none", "name": "Cations", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617308", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617306", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617233", "map_id": "none", "name": "RAPGEF3:cAMP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34578", "map_id": "P34578", "name": "epac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617202", "map_id": "none", "name": "RAPGEF4:cAMP Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617235", "map_id": "none", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10617228", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617218", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10617226", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617204", "map_id": "none", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617200", "map_id": "P34578", "name": "epac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10617304", "map_id": "none", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617302", "map_id": "none", "name": "Potassium voltage-gated channels (beta cell, open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XXD1", "map_id": "Q9XXD1", "name": "kvs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012967", "map_id": "WBGene00012967", "name": "kvs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PLR3", "map_id": "U4PLR3", "name": "kvs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021948", "map_id": "WBGene00021948", "name": "kvs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC00", "map_id": "G5EC00", "name": "shw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008819", "map_id": "WBGene00008819", "name": "shw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZQ6", "map_id": "H2KZQ6", "name": "exp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001374", "map_id": "WBGene00001374", "name": "exp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1E007", "map_id": "A0A3B1E007", "name": "shw-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004793", "map_id": "WBGene00004793", "name": "shw-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "J3K003", "map_id": "J3K003", "name": "kvs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007862", "map_id": "WBGene00007862", "name": "kvs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0INI0", "map_id": "A0A4V0INI0", "name": "kvs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002242", "map_id": "WBGene00002242", "name": "kvs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC3", "map_id": "G5EFC3", "name": "egl-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001202", "map_id": "WBGene00001202", "name": "egl-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20381", "map_id": "Q20381", "name": "kvs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018402", "map_id": "WBGene00018402", "name": "kvs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601861", "map_id": "none", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601855", "map_id": "none", "name": "RNA Polymerase I Transcription Initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P46064", "map_id": "P46064", "name": "tag-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006430", "map_id": "WBGene00006430", "name": "tag-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27493", "map_id": "Q27493", "name": "rpoa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008781", "map_id": "WBGene00008781", "name": "rpoa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17587", "map_id": "O17587", "name": "rpoa-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007616", "map_id": "WBGene00007616", "name": "rpoa-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED21", "map_id": "G5ED21", "name": "rpoa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012999", "map_id": "WBGene00012999", "name": "rpoa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01914", "map_id": "O01914", "name": "Ac-TAF1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017758", "map_id": "WBGene00017758", "name": "Ac-TAF1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48322", "map_id": "P48322", "name": "RRN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007980", "map_id": "WBGene00007980", "name": "RRN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAY9", "map_id": "Q9UAY9", "name": "rpac-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019275", "map_id": "WBGene00019275", "name": "rpac-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95X83", "map_id": "Q95X83", "name": "rpoa-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017749", "map_id": "WBGene00017749", "name": "rpoa-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601775", "map_id": "P48322", "name": "RRN3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601859", "map_id": "none", "name": "RNA Polymerase I promoter escape complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601779", "map_id": "none", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601770", "map_id": "none", "name": "RNA Polymerase I Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601777", "map_id": "none", "name": "Active RNA Polymerase I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602569", "map_id": "none", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_350", "compartment_display": "nucleolus" }, { "id": "species_74985", "map_id": "none", "name": "elongating pre-rRNA transcript", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602567", "map_id": "none", "name": "Chromatin (H3K9me2):CBX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EET5", "map_id": "G5EET5", "name": "hpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001995", "map_id": "WBGene00001995", "name": "hpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637186", "map_id": "none", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637182", "map_id": "G5ECE8", "name": "chhy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1297302", "map_id": "CHEBI:16336", "name": "HUA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10637184", "map_id": "none", "name": "SPAM1:Hyaluronic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10637196", "map_id": "none", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637193", "map_id": "none", "name": "Slo3 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95V25", "map_id": "Q95V25", "name": "slo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004830", "map_id": "WBGene00004830", "name": "slo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614415", "map_id": "none", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614410", "map_id": "none", "name": "EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612190", "map_id": "Q22070", "name": "phospho-plc-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10604456", "map_id": "none", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10608588", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608585", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614408", "map_id": "none", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612156", "map_id": "Q22070", "name": "plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614406", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608477", "map_id": "none", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608473", "map_id": "none", "name": "EGFR:EGF-like ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10608475", "map_id": "none", "name": "EGF-like ligands:EGFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608603", "map_id": "none", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10608581", "map_id": "none", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608578", "map_id": "G5EE56", "name": "src-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10665754", "map_id": "none", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_459", "compartment_display": "cytoplasm" }, { "id": "species_10608466", "map_id": "P24348", "name": "let-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10665750", "map_id": "E0R7L2", "name": "AAMP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013735", "map_id": "WBGene00013735", "name": "AAMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665752", "map_id": "none", "name": "EGFR:AAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "E0R7L2", "map_id": "E0R7L2", "name": "AAMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608566", "map_id": "none", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10608612", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608609", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10608601", "map_id": "none", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10608471", "map_id": "G5EFK8", "name": "EGF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10614413", "map_id": "none", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10598294", "map_id": "none", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598290", "map_id": "none", "name": "CCNE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10598292", "map_id": "none", "name": "CCNE:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10609629", "map_id": "none", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609624", "map_id": "none", "name": "CCNE:p-T160-CDK2:hypophosphorylated RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605292", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10598141", "map_id": "none", "name": "Cyclin E:p-T160-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10609622", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10609626", "map_id": "none", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598311", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605940", "map_id": "none", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10638555", "map_id": "none", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_874088", "map_id": "CHEBI:16991", "name": "Double-stranded DNA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10638551", "map_id": "Q23255", "name": "mre-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003405", "map_id": "WBGene00003405", "name": "mre-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638553", "map_id": "none", "name": "MRE11:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23255", "map_id": "Q23255", "name": "mre-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645205", "map_id": "none", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645197", "map_id": "none", "name": "p21 RAS:GTP:p-S338-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10645203", "map_id": "none", "name": "p21 RAS:GTP:p-S338,Y340,Y341-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613791", "map_id": "G5EE56", "name": "src-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10644469", "map_id": "none", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10642488", "map_id": "P34722", "name": "phospho-tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644467", "map_id": "none", "name": "DAGs:p-T507,S645,S664-PRKCD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10653154", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10653046", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "Q20665", "map_id": "Q20665", "name": "CLEC4D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00255469", "map_id": "WBGene00255469", "name": "CLEC4D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4W4", "map_id": "Q9N4W4", "name": "clec-205", "type": "complex_component", "sub_type": "protein_component", 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"false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A061AD52", "map_id": "A0A061AD52", "name": "CLEC4D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17441", "map_id": "Q17441", "name": "tsp-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006646", "map_id": "WBGene00006646", "name": "tsp-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUF4", "map_id": "Q9XUF4", "name": "clec-198", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008203", "map_id": "WBGene00008203", "name": "clec-198", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTY9", "map_id": "Q9XTY9", "name": "vha-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010993", "map_id": "WBGene00010993", "name": "vha-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21146", "map_id": "Q21146", "name": "clec-149", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019328", "map_id": "WBGene00019328", "name": "clec-149", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFM5", "map_id": "G5EFM5", "name": "clec-185", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007729", "map_id": "WBGene00007729", "name": "clec-185", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX56", "map_id": "Q9XX56", "name": "CLEC4D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI4", "map_id": "Q9XVI4", "name": "tsp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006633", "map_id": "WBGene00006633", "name": "tsp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4RWX0", "map_id": "G4RWX0", "name": "tsp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006632", "map_id": "WBGene00006632", "name": "tsp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0S4XR36", "map_id": "A0A0S4XR36", "name": "ubr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C44E4.1d", "map_id": "C44E4.1d", "name": "ubr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45275", "map_id": "O45275", "name": "clec-202", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007822", "map_id": "WBGene00007822", "name": "clec-202", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20707", "map_id": "Q20707", "name": "tsp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006630", "map_id": "WBGene00006630", "name": "tsp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44827", "map_id": "O44827", "name": "fgt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019207", "map_id": "WBGene00019207", "name": "fgt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17526", "map_id": "Q17526", "name": "tsp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006637", "map_id": "WBGene00006637", "name": "tsp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19983", "map_id": "Q19983", "name": "tsp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006634", "map_id": "WBGene00006634", "name": "tsp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93874", "map_id": "Q93874", "name": "rab-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004276", "map_id": "WBGene00004276", "name": "rab-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRN9", "map_id": "Q5WRN9", "name": "clec-184", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023502", "map_id": "WBGene00023502", "name": "clec-184", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVM9", "map_id": "Q9XVM9", "name": "tsp-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006641", "map_id": "WBGene00006641", "name": "tsp-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXU1", "map_id": "Q1ZXU1", "name": "clec-224", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044790", "map_id": 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"type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004308", "map_id": "WBGene00004308", "name": "rap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFD9", "map_id": "G5EFD9", "name": "phospho-sup-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006324", "map_id": "WBGene00006324", "name": "phospho-sup-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4W5", "map_id": "Q9N4W5", "name": "clec-204", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021603", "map_id": "WBGene00021603", "name": "clec-204", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18821", "map_id": "Q18821", "name": "clec-86", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016912", "map_id": "WBGene00016912", "name": "clec-86", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21750", "map_id": "Q21750", "name": "aagr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019895", "map_id": "WBGene00019895", "name": "aagr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91214", "map_id": "P91214", "name": "clec-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017199", "map_id": "WBGene00017199", "name": "clec-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62466", "map_id": "O62466", "name": "tsp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006631", "map_id": "WBGene00006631", "name": "tsp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L006", "map_id": "H2L006", "name": "tsp-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006640", "map_id": "WBGene00006640", "name": "tsp-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC7", "map_id": "G5EFC7", "name": "lyst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011361", "map_id": "WBGene00011361", "name": "lyst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBV8", "map_id": "U4PBV8", "name": "tat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019166", "map_id": "WBGene00019166", "name": "tat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18076", "map_id": "O18076", "name": "clec-47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011668", "map_id": "WBGene00011668", "name": "clec-47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRN1", "map_id": "Q5WRN1", "name": "tsp-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023491", "map_id": "WBGene00023491", "name": "tsp-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10653152", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10644482", "map_id": "none", "name": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10644480", "map_id": "Q22070", "name": "phospho-plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644471", "map_id": "Q22070", "name": "phospho-plc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10625987", "map_id": "none", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625973", "map_id": "none", "name": "Homologues of K63polyUb-DDX58", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625979", "map_id": "none", "name": "Homologues of DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625984", "map_id": "Q7JMS4", "name": "cyld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009594", "map_id": "WBGene00009594", "name": "cyld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645210", "map_id": "none", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645207", "map_id": "none", "name": "p21 RAS:GTP:RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617744", "map_id": "none", "name": "PAK1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657872", "map_id": "none", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10657866", "map_id": "A0A1N7SYP5", "name": "CR2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00009500", "map_id": "WBGene00009500", "name": "CD46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657868", "map_id": "none", "name": "C3d, C3dg, iC3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7YTU0", "map_id": "Q7YTU0", "name": "tep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013969", "map_id": "WBGene00013969", "name": "tep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8F7Z5", "map_id": "K8F7Z5", "name": "C3c alpha' chain fragment 2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008735", "map_id": "WBGene00008735", "name": "C3c alpha' chain fragment 2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657870", "map_id": "none", "name": "CR2:C3d,C3dg,iC3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A1N7SYP5", "map_id": "A0A1N7SYP5", "name": "CD46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661671", "map_id": "none", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627143", "map_id": "none", "name": "Cell surface:C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627117", "map_id": "A0A1N7SYP5", "name": "CD46", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10627145", "map_id": "none", "name": "CD46:Cell surface:C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10655607", "map_id": "none", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8931784", "map_id": "none", "name": "Anionic phospholipids:microbial cell surface", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "CHEBI:62643", "map_id": "CHEBI:62643", "name": "CHEBI:62643", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655569", "map_id": "none", "name": "Homologues of REG3A(38-175)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10655571", "map_id": "none", "name": "REG3A(38-175):anionic phospholipids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10612177", "map_id": "none", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611846", "map_id": "P34722", "name": "tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612175", "map_id": "none", "name": "PKC-theta (open): DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10644478", "map_id": "none", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10652445", "map_id": "none", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10652253", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "P91857", "map_id": "P91857", "name": "rab-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004268", "map_id": "WBGene00004268", "name": "rab-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC10", "map_id": "G5EC10", "name": "phospho-lec-9", "type": "complex_component", "sub_type": "protein_component", "inferred": 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"compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002271", "map_id": "WBGene00002271", "name": "phospho-lec-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2I7", "map_id": "Q9U2I7", "name": "phospho-pqn-84", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004165", "map_id": "WBGene00004165", "name": "phospho-pqn-84", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16795", "map_id": "O16795", "name": "nep-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017550", "map_id": "WBGene00017550", "name": "nep-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10627056", "map_id": "Q23528", "name": "try-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00006619", "map_id": "WBGene00006619", "name": "try-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627058", "map_id": "Q23528", "name": "try-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10627060", "map_id": "none", "name": "CFI", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q23528", "map_id": "Q23528", "name": "try-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637568", "map_id": "none", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637562", "map_id": "G5EE56", "name": "src-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10637565", "map_id": "G5EE56", "name": "phospho-src-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10663891", "map_id": "none", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638461", "map_id": "Q9N5K1", "name": "sacy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019245", "map_id": "WBGene00019245", "name": "sacy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8982080", "map_id": "none", "name": "c-di-AMP, c-di-GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49537", "map_id": "CHEBI:49537", "name": "CHEBI:49537", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47037", "map_id": "CHEBI:47037", "name": "CHEBI:47037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663889", "map_id": "none", "name": "DDX41:c-di-AMP, c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N5K1", "map_id": "Q9N5K1", "name": "sacy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635404", "map_id": "none", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10635401", "map_id": "none", "name": "PLD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19056", "map_id": "Q19056", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020256", "map_id": "WBGene00020256", "name": "PLD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17405", "map_id": "O17405", "name": "PLD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017316", "map_id": "WBGene00017316", "name": "PLD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ05", "map_id": "H2KZ05", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4C7", "map_id": "Q8I4C7", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657864", "map_id": "none", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10657846", "map_id": "none", "name": "C3a, C5a", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10657848", "map_id": "none", "name": "C3a-desArg, C5a-desArg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10657861", "map_id": "none", "name": "CPN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9N5D7", "map_id": "Q9N5D7", "name": "lron-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020693", "map_id": "WBGene00020693", "name": "lron-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17754", "map_id": "O17754", "name": "egl-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001189", "map_id": "WBGene00001189", "name": "egl-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5Z3", "map_id": "Q9N5Z3", "name": "tol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006593", "map_id": "WBGene00006593", "name": "tol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637988", "map_id": "none", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10607167", "map_id": "none", "name": "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10627129", "map_id": "none", "name": "deamidated-Q1013-C4A-derived C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10645212", "map_id": "none", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618102", "map_id": "Q07292", "name": "lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10655475", "map_id": "none", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10655427", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800405", "compartment_display": "ficolin-1-rich granule lumen", "complex": "true" }, { "id": "P34664", "map_id": "P34664", "name": "KCMF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022785", "map_id": "WBGene00022785", "name": "KCMF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P43510", "map_id": "P43510", "name": "cpr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000786", "map_id": "WBGene00000786", "name": "cpr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21742", "map_id": "Q21742", "name": "PGM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019890", "map_id": "WBGene00019890", "name": "PGM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IAA9", "map_id": "Q8IAA9", "name": "clp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000545", "map_id": "WBGene00000545", "name": "clp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20911", "map_id": "Q20911", "name": "cubn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013855", "map_id": "WBGene00013855", "name": "cubn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYX1", "map_id": "Q9TYX1", "name": "dpf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001058", "map_id": "WBGene00001058", "name": "dpf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBQ7", "map_id": "U4PBQ7", "name": "YPEL5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015250", "map_id": "WBGene00015250", "name": "YPEL5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45686", "map_id": "O45686", "name": "asah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010769", "map_id": "WBGene00010769", "name": "asah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4B2", "map_id": "Q9N4B2", "name": "clp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000546", "map_id": "WBGene00000546", "name": "clp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECM9", "map_id": "G5ECM9", "name": "phospho-cpi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000534", "map_id": "WBGene00000534", "name": "phospho-cpi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2B2", "map_id": "Q9U2B2", "name": "clp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000544", "map_id": "WBGene00000544", "name": "clp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4B1", "map_id": "Q9N4B1", "name": "clp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000547", "map_id": "WBGene00000547", "name": "clp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34308", "map_id": "P34308", "name": "clp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000542", "map_id": "WBGene00000542", "name": "clp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655473", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10610934", "map_id": "none", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610931", "map_id": "none", "name": "Phospho-PKC-delta/epsilon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637560", "map_id": "none", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612161", "map_id": "none", "name": "p-Y90-PKC-theta:DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10637558", "map_id": "none", "name": "p-5Y-PKC-theta:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607959", "map_id": "none", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10607181", "map_id": "none", "name": "Complement factor 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10607957", "map_id": "none", "name": "C3(H2O)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10627220", "map_id": "none", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607189", "map_id": "none", "name": "C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10627236", "map_id": "none", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10627155", "map_id": "none", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627151", "map_id": "none", "name": "CD46, CR1:C4b:C3b complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627153", "map_id": "none", "name": "CFI:CD46, CR1:C4b, C3b complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627210", "map_id": "none", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627185", "map_id": "none", "name": "CD46, CR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627183", "map_id": "none", "name": "C4d, iC3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627207", "map_id": "none", "name": "C4c, C3f", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10652817", "map_id": "none", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen" }, { "id": "species_10652705", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen", "complex": "true" }, { "id": "Q4W5T6", "map_id": "Q4W5T6", "name": "METTL7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044310", "map_id": "WBGene00044310", "name": "METTL7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20587", "map_id": "Q20587", "name": "METTL7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22993", "map_id": "Q22993", "name": "pmt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018811", "map_id": "WBGene00018811", "name": "pmt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U204", "map_id": "Q9U204", "name": "GOLGA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013323", "map_id": "WBGene00013323", "name": "GOLGA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10652815", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10635284", "map_id": "none", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655079", "map_id": "none", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane" }, { "id": "species_10655055", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane", "complex": "true" }, { "id": "Q9U308", "map_id": "Q9U308", "name": "jac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002175", "map_id": "WBGene00002175", "name": "jac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYK0", "map_id": "Q9GYK0", "name": "lmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015471", "map_id": "WBGene00015471", "name": "lmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19833", "map_id": "Q19833", "name": "C16orf62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017837", "map_id": "WBGene00017837", "name": "C16orf62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDC6", "map_id": "G5EDC6", "name": "arl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000192", "map_id": "WBGene00000192", "name": "arl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17540", "map_id": "Q17540", "name": "ENPP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015283", "map_id": "WBGene00015283", "name": "ENPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q53U87", "map_id": "Q53U87", "name": "sax-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004732", "map_id": "WBGene00004732", "name": "sax-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44873", "map_id": "O44873", "name": "tbc-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019915", "map_id": "WBGene00019915", "name": "tbc-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19319", "map_id": "Q19319", "name": "cdh-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000396", "map_id": "WBGene00000396", "name": "cdh-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34676", "map_id": "P34676", "name": "pcp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022801", "map_id": "WBGene00022801", "name": "pcp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11117", "map_id": "Q11117", "name": "lmp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003053", "map_id": "WBGene00003053", "name": "lmp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGJ5", "map_id": "G5EGJ5", "name": "ida-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002048", "map_id": "WBGene00002048", "name": "ida-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655077", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10655833", "map_id": "none", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10655831", "map_id": "none", "name": "BPI:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10654694", "map_id": "none", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane" }, { "id": "species_10654652", "map_id": "none", "name": "Specific granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane", "complex": "true" }, { "id": "E5QCE7", "map_id": "E5QCE7", "name": "dnj-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001032", "map_id": "WBGene00001032", "name": "dnj-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16547", "map_id": "O16547", "name": "SLC2A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022014", "map_id": "WBGene00022014", "name": "SLC2A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35602", "map_id": "P35602", "name": "unc-101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006829", "map_id": "WBGene00006829", "name": "unc-101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3Y5", "map_id": "Q9N3Y5", "name": "TMBIM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021537", "map_id": "WBGene00021537", "name": "TMBIM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ55", "map_id": "Q8MQ55", "name": "xbx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009580", "map_id": "WBGene00009580", "name": "xbx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVL3", "map_id": "Q9XVL3", "name": "SLC2A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU83", "map_id": "Q9XU83", "name": "SLC2A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23626", "map_id": "Q23626", "name": "SLC2A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83351", "map_id": "P83351", "name": "snap-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019305", "map_id": "WBGene00019305", "name": "snap-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10651829", "map_id": "none", "name": "Azurophil granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665782", "map_id": "none", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678991", "map_id": "LigandDisplayForward?ligandId=6784", "name": "tacrolimus", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10607014", "map_id": "none", "name": "Homologues of FKBP1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45418", "map_id": "O45418", "name": "fkb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001431", "map_id": "WBGene00001431", "name": "fkb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4E5", "map_id": "Q8I4E5", "name": "fkb-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001433", "map_id": "WBGene00001433", "name": "fkb-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2Q8", "map_id": "Q9U2Q8", "name": "fkb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001427", "map_id": "WBGene00001427", "name": "fkb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665780", "map_id": "none", "name": "FKBP1A:tacrolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10629435", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629432", "map_id": "none", "name": "Homologues of KCNN4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17697", "map_id": "O17697", "name": "kcnl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008265", "map_id": "WBGene00008265", "name": "kcnl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11122", "map_id": "Q11122", "name": "kcnl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015387", "map_id": "WBGene00015387", "name": "kcnl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLK4", "map_id": "V6CLK4", "name": "kcnl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008570", "map_id": "WBGene00008570", "name": "kcnl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFI1", "map_id": "G5EFI1", "name": "kcnl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007176", "map_id": "WBGene00007176", "name": "kcnl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629464", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629461", "map_id": "none", "name": "Small conductance Ca2+ activated potassium channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10610716", "map_id": "none", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609928", "map_id": "none", "name": "planar gap junction plaques associated with Dab2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A486WXX8", "map_id": "A0A486WXX8", "name": "phospho-dab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000894", "map_id": "WBGene00000894", "name": "phospho-dab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609939", "map_id": "none", "name": "Planar gap junction plaques associated with Dab2 and Dynamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10610718", "map_id": "none", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609921", "map_id": "none", "name": "planar gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10609926", "map_id": "A0A486WXX8", "name": "dab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10666007", "map_id": "none", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10666001", "map_id": "none", "name": "AcK685- p-Y705,S727-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10665989", "map_id": "none", "name": "p-Y705,S727-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628319", "map_id": "O17695", "name": "hda-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10666004", "map_id": "none", "name": "p-Y705,S727 STAT3 is acetylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10623765", "map_id": "none", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_432019", "map_id": "CHEBI:16199", "name": "Urea", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10623762", "map_id": "none", "name": "AQP9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10623760", "map_id": "none", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623753", "map_id": "none", "name": "AQP3,7,9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621827", "map_id": "none", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621824", "map_id": "none", "name": "AQP3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10623751", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623748", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09369", "map_id": "Q09369", "name": "aqp-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000178", "map_id": "WBGene00000178", "name": "aqp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46024", "map_id": "O46024", "name": "aqp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000179", "map_id": "WBGene00000179", "name": "aqp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEK0", "map_id": "G5EEK0", "name": "aqp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000172", "map_id": "WBGene00000172", "name": "aqp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623756", "map_id": "none", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10623767", "map_id": "none", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10623758", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10643263", "map_id": "none", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643259", "map_id": "none", "name": "CYGB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17824", "map_id": "O17824", "name": "glb-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008996", "map_id": "WBGene00008996", "name": "glb-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643261", "map_id": "none", "name": "CYGB dimer:O2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663022", "map_id": "none", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663018", "map_id": "none", "name": "NGB:ferroheme b:O2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7YZV1", "map_id": "Q7YZV1", "name": "glb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016024", "map_id": "WBGene00016024", "name": "glb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663016", "map_id": "none", "name": "NGB:ferroheme b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663249", "map_id": "none", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10663020", "map_id": "none", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10619462", "map_id": "none", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619459", "map_id": "B3WFV9", "name": "abts-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10619469", "map_id": "none", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619464", "map_id": "B3WFV9", "name": "abts-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10619454", "map_id": "none", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619447", "map_id": "Q58QG8", "name": "abts-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10647253", "map_id": "none", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647189", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647227", "map_id": "none", "name": "MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647250", "map_id": "none", "name": "cytosolic MAPK DUSPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10038", "map_id": "Q10038", "name": "vhp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006923", "map_id": "WBGene00006923", "name": "vhp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605081", "map_id": "none", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605072", "map_id": "none", "name": "MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604506", "map_id": "Q10664", "name": "phospho-mek-2", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605078", "map_id": "P34556", "name": "phospho-cdk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10647195", "map_id": "none", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647193", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604479", "map_id": "none", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604463", "map_id": "Q10664", "name": "phospho-mek-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10604475", "map_id": "none", "name": "Homologues of MAPK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604477", "map_id": "none", "name": "p-2S-MAP2K1:MAPK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604510", "map_id": "none", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604501", "map_id": "none", "name": "p-T,Y-MAPK3:p-2S-MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604522", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604499", "map_id": "none", "name": "Homologues of p-T202,Y204-MAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638746", "map_id": "none", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622515", "map_id": "none", "name": "MAP2K3,MAP2K6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638729", "map_id": "Q21029", "name": "nsy-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003822", "map_id": "WBGene00003822", "name": "nsy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638836", "map_id": "none", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638821", "map_id": "none", "name": "phospho-p38 MAPK: MAPKAPK5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638833", "map_id": "none", "name": "phospho-p38 MAPK:p-T-182-MAPKAPK5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10662912", "map_id": "none", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638719", "map_id": "none", "name": "Homologues of KDM6B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638721", "map_id": "none", "name": "KDM6B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638742", "map_id": "none", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638731", "map_id": "none", "name": "MAP3K5:TXN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45017", "map_id": "O45017", "name": "2xHC-TXN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21029", "map_id": "Q21029", "name": "nsy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638736", "map_id": "Q23356", "name": "mig-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003247", "map_id": "WBGene00003247", "name": "mig-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638724", "map_id": "none", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638705", "map_id": "none", "name": "CDKN2A Gene:H3K27Me3-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638707", "map_id": "none", "name": "CDKN2A Gene:Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638823", "map_id": "none", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638819", "map_id": "none", "name": "p38 MAPK:MAPKAPK5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638839", "map_id": "none", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614316", "map_id": "none", "name": "PRC2 (EZH2) Core", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9GYS1", "map_id": "Q9GYS1", "name": "mes-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003224", "map_id": "WBGene00003224", "name": "mes-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17514", "map_id": "O17514", "name": "mes-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003220", "map_id": "WBGene00003220", "name": "mes-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621550", "map_id": "none", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621548", "map_id": "none", "name": "Active c-Src:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621571", "map_id": "none", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621567", "map_id": "none", "name": "YWHAZ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621569", "map_id": "none", "name": "14-3-3-zeta:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10613690", "map_id": "none", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71112", "map_id": "CHEBI:15374", "name": "4aOH-BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209911", "map_id": "CHEBI:17780", "name": "5HTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613687", "map_id": "none", "name": "TPH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EED8", "map_id": "G5EED8", "name": "tph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006600", "map_id": "WBGene00006600", "name": "tph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613711", "map_id": "none", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613708", "map_id": "none", "name": "DDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45137", "map_id": "O45137", "name": "bas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000239", "map_id": "WBGene00000239", "name": "bas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597831", "map_id": "none", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597827", "map_id": "Q9U2C2", "name": "mcm-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012935", "map_id": "WBGene00012935", "name": "mcm-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597829", "map_id": "none", "name": "MCM10:pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U2C2", "map_id": "Q9U2C2", "name": "mcm-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630180", "map_id": "none", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630172", "map_id": "none", "name": "MuvB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P30630", "map_id": "P30630", "name": "lin-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002998", "map_id": "WBGene00002998", "name": "lin-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QD7", "map_id": "Q95QD7", "name": "lin-54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003037", "map_id": "WBGene00003037", "name": "lin-54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23482", "map_id": "Q23482", "name": "lin-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003022", "map_id": "WBGene00003022", "name": "lin-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10120", "map_id": "Q10120", "name": "lin-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003035", "map_id": "WBGene00003035", "name": "lin-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630164", "map_id": "none", "name": "p-MuvB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10630177", "map_id": "Q8WQL7", "name": "mbk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003149", "map_id": "WBGene00003149", "name": "mbk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630243", "map_id": "none", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630235", "map_id": "none", "name": "Cyclin E/A:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10630241", "map_id": "none", "name": "RBL2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597751", "map_id": "none", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597742", "map_id": "none", "name": "DNA polymerase epsilon:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605320", "map_id": "none", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113656", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605294", "map_id": "none", "name": "RB1:RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605317", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605322", "map_id": "none", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10628796", "map_id": "none", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628773", "map_id": "none", "name": "RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628794", "map_id": "none", "name": "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597837", "map_id": "none", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597780", "map_id": "Q86S68", "name": "cdt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597835", "map_id": "none", "name": "MCM10:active pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10630247", "map_id": "none", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628784", "map_id": "none", "name": "RBL1:E2F4:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10630245", "map_id": "none", "name": "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628800", "map_id": "none", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628798", "map_id": "none", "name": "HDAC1:RBL1:E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598120", "map_id": "none", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68419", "map_id": "none", "name": "origin of replication", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10630168", "map_id": "none", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630166", "map_id": "none", "name": "DREAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10630251", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630249", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10630239", "map_id": "none", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10630237", "map_id": "none", "name": "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638114", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638089", "map_id": "P55853", "name": "smo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638074", "map_id": "P55853", "name": "smo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638111", "map_id": "none", "name": "SENP1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641285", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641283", "map_id": "none", "name": "SUMO1:HIST1H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641349", "map_id": "none", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641347", "map_id": "none", "name": "2SUMO1:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641371", "map_id": "none", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628321", "map_id": "O17695", "name": "hda-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641369", "map_id": "none", "name": "SUMO1:HDAC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641338", "map_id": "none", "name": "RANBP2 SUMOylates HDAC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641328", "map_id": "O17323", "name": "hda-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001837", "map_id": "WBGene00001837", "name": "hda-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641336", "map_id": "none", "name": "SUMO1:HDAC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17323", "map_id": "O17323", "name": "hda-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662809", "map_id": "none", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640202", "map_id": "none", "name": "Homologues of CHD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10662801", "map_id": "none", "name": "SUMO1:CHD3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10662806", "map_id": "Q21374", "name": "ZBED1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00010704", "map_id": "WBGene00010704", "name": "ZBED1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604149", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604146", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00017867", "map_id": "WBGene00017867", "name": "slc-28.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665056", "map_id": "none", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879603", "map_id": "none", "name": "T3,T4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352326", "map_id": "CHEBI:18332", "name": "T4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_879628", "map_id": "none", "name": "T3,T4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610517", "map_id": "none", "name": "Homologues of SLCO1B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20538", "map_id": "Q20538", "name": "Q20538", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018566", "map_id": "WBGene00018566", "name": "Q20538", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZT3", "map_id": "Q95ZT3", "name": "SLCO1A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018568", "map_id": "WBGene00018568", "name": "SLCO1A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62421", "map_id": "O62421", "name": "SLCO1A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624695", "map_id": "none", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727753", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10624692", "map_id": "Q22816", "name": "SLC33A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00012033", "map_id": "WBGene00012033", "name": "SLC33A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604142", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604126", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00009499", "map_id": "WBGene00009499", "name": "ent-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610539", "map_id": "none", "name": "Transport (influx) of bile salts and acids by OATP-A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_192483", "map_id": "none", "name": "bile salts and acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:9407", "map_id": "CHEBI:9407", "name": "CHEBI:9407", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_194156", "map_id": "none", "name": "bile salts and acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610536", "map_id": "none", "name": "Homologues of SLCO1A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10610509", "map_id": "none", "name": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_194117", "map_id": "none", "name": "GCCA, TCCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_194097", "map_id": "none", "name": "GCCA, TCCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610506", "map_id": "none", "name": "Homologues of SLCO1B3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606540", "map_id": "none", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10606537", "map_id": "none", "name": "SLC25A5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P91270", "map_id": "P91270", "name": "SLC25A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017770", "map_id": "WBGene00017770", "name": "SLC25A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625070", "map_id": "none", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879553", "map_id": "none", "name": "SLCO2B1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:63836", "map_id": "CHEBI:63836", "name": "CHEBI:63836", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879654", "map_id": "none", "name": "SLCO2B1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625067", "map_id": "Q20538", "name": "SLCO2B1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10610520", "map_id": "none", "name": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10625124", "map_id": "none", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879521", "map_id": "CHEBI:4551", "name": "DIGX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_879517", "map_id": "CHEBI:4551", "name": "DIGX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625121", "map_id": "none", "name": "Homologues of SLCO4C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625088", "map_id": "none", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625085", "map_id": "none", "name": "SLCOs, SLC16A2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604129", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179747", "map_id": "none", "name": "ligands of SLC29A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83960", "map_id": "CHEBI:17821", "name": "Thy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83951", "map_id": "CHEBI:16708", "name": "Ade", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:16040", "map_id": "CHEBI:16040", "name": "CHEBI:16040", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_179742", "map_id": "none", "name": "ligands of SLC29A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604124", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10604154", "map_id": "none", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179740", "map_id": "none", "name": "ligands of SLC28A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_179741", "map_id": "none", "name": "ligands of SLC28A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604151", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10604131", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625107", "map_id": "none", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879559", "map_id": "none", "name": "LCFAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:28866", "map_id": "CHEBI:28866", "name": "CHEBI:28866", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28822", "map_id": "CHEBI:28822", "name": "CHEBI:28822", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30813", "map_id": "CHEBI:30813", "name": "CHEBI:30813", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879544", "map_id": "none", "name": "LCFAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625104", "map_id": "none", "name": "SLC27A1,4,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624687", "map_id": "none", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727782", "map_id": "none", "name": "nucleosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_727746", "map_id": "none", "name": "nucleosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624684", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10604139", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179738", "map_id": "none", "name": "ligands of SLC28A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179739", "map_id": "none", "name": "ligands of SLC28A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604136", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10625065", "map_id": "none", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879566", "map_id": "none", "name": "PGT substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:15544", "map_id": "CHEBI:15544", "name": "CHEBI:15544", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879614", "map_id": "none", "name": "PGT substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625062", "map_id": "none", "name": "Homologues of SLCO2A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604144", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661501", "map_id": "none", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611220", "map_id": "G5EE01", "name": "daf-18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000913", "map_id": "WBGene00000913", "name": "phospho-daf-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10655821", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10661452", "map_id": "none", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661444", "map_id": "Q9TZN2", "name": "mafr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016622", "map_id": "WBGene00016622", "name": "phospho-mafr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661449", "map_id": "Q9TZN2", "name": "phospho-mafr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10655808", "map_id": "none", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10655802", "map_id": "G5EE01", "name": "daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611223", "map_id": "none", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655829", "map_id": "none", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655826", "map_id": "U4PBM0", "name": "duo-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001112", "map_id": "WBGene00001112", "name": "duo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661506", "map_id": "none", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661503", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657634", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10639898", "map_id": "Q8WQB0", "name": "RNF146", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013674", "map_id": "WBGene00013674", "name": "RNF146", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661454", "map_id": "none", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10661442", "map_id": "Q9TZN2", "name": "mafr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10636497", "map_id": "none", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611215", "map_id": "none", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611003", "map_id": "G5EED4", "name": "nipi-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10610986", "map_id": "none", "name": "AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611005", "map_id": "none", "name": "AKT:PIP3:THEM4/TRIB3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10661299", "map_id": "none", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640221", "map_id": "none", "name": "NuRD complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661293", "map_id": "none", "name": "SALL4:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFF4", "map_id": "G5EFF4", "name": "sem-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004773", "map_id": "WBGene00004773", "name": "sem-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661297", "map_id": "none", "name": "SALL4:NuRD:PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657264", "map_id": "none", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657260", "map_id": "O45539", "name": "phospho-src-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657262", "map_id": "none", "name": "PTEN:p-Y387-FRK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE01", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636439", "map_id": "none", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636437", "map_id": "none", "name": "PDPK1:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636520", "map_id": "none", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610889", "map_id": "none", "name": "p-S-AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10610891", "map_id": "none", "name": "p-S-AKT:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657270", "map_id": "none", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657267", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10655800", "map_id": "none", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655794", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655798", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611007", "map_id": "none", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10657638", "map_id": "none", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657636", "map_id": "none", "name": "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10655818", "map_id": "none", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10655811", "map_id": "G5EE01", "name": "daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655815", "map_id": "none", "name": "NEDD4,STUB1,WWP2 and XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636522", "map_id": "none", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655805", "map_id": "none", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648336", "map_id": "Q7JKC3", "name": "math-33", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638301", "map_id": "H2L0K3", "name": "nhl-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003599", "map_id": "WBGene00003599", "name": "nhl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610912", "map_id": "none", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661311", "map_id": "none", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661303", "map_id": "none", "name": "PRC1.4,PRC2 (EZH2) core", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661305", "map_id": "none", "name": "MECOM:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22024", "map_id": "Q22024", "name": "egl-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661309", "map_id": "none", "name": "MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657626", "map_id": "none", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657624", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599349", "map_id": "none", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31135", "map_id": "CHEBI:17105", "name": "4MAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599346", "map_id": "none", "name": "HGD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9Y041", "map_id": "Q9Y041", "name": "hgo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001843", "map_id": "WBGene00001843", "name": "hgo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599320", "map_id": "none", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29506", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599317", "map_id": "none", "name": "TAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93703", "map_id": "Q93703", "name": "tatn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009628", "map_id": "WBGene00009628", "name": "tatn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599339", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599336", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22633", "map_id": "Q22633", "name": "hpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001993", "map_id": "WBGene00001993", "name": "hpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18347", "map_id": "Q18347", "name": "HPD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016294", "map_id": "WBGene00016294", "name": "HPD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198836", "map_id": "CHEBI:38290", "name": "AscH-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10599369", "map_id": "none", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31175", "map_id": "CHEBI:18034", "name": "4FAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29586", "map_id": "CHEBI:29806", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599366", "map_id": "none", "name": "FAH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94272", "map_id": "Q94272", "name": "fah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019620", "map_id": "WBGene00019620", "name": "fah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599359", "map_id": "none", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599356", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10630983", "map_id": "none", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10630980", "map_id": "Q23598", "name": "acl-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00006491", "map_id": "WBGene00006491", "name": "acl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631012", "map_id": "none", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524080", "map_id": "CHEBI:60431", "name": "DLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524069", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10603026", "map_id": "O16526", "name": "acl-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020264", "map_id": "WBGene00020264", "name": "acl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631010", "map_id": "none", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524081", "map_id": "CHEBI:28494", "name": "CL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10630999", "map_id": "none", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10630972", "map_id": "none", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10630969", "map_id": "none", "name": "HADH octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10666115", "map_id": "none", "name": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10666095", "map_id": "Q86ME6", "name": "dop-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10666101", "map_id": "none", "name": "GNAL:GDP:GNB1:GNG13", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9712200", "map_id": "none", "name": "odorant", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:28837", "map_id": "CHEBI:28837", "name": "CHEBI:28837", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16424", "map_id": "CHEBI:16424", "name": "CHEBI:16424", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17580", "map_id": "CHEBI:17580", "name": "CHEBI:17580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:17356", "map_id": "pubchem.compound:17356", "name": "pubchem.compound:17356", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:86192", "map_id": "CHEBI:86192", "name": "CHEBI:86192", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15409", "map_id": "CHEBI:15409", "name": "CHEBI:15409", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16731", "map_id": "CHEBI:16731", "name": "CHEBI:16731", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:45571", "map_id": "CHEBI:45571", "name": "CHEBI:45571", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:4917", "map_id": "CHEBI:4917", "name": "CHEBI:4917", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:4918", "map_id": "CHEBI:4918", "name": "CHEBI:4918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:17072", "map_id": "pubchem.compound:17072", "name": "pubchem.compound:17072", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36740", "map_id": "CHEBI:36740", "name": "CHEBI:36740", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15400", "map_id": "CHEBI:15400", "name": "CHEBI:15400", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:168721", "map_id": "CHEBI:168721", "name": "CHEBI:168721", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:5331", "map_id": "CHEBI:5331", "name": "CHEBI:5331", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17362", "map_id": "CHEBI:17362", "name": "CHEBI:17362", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:29452", "map_id": "CHEBI:29452", "name": "CHEBI:29452", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30065", "map_id": "CHEBI:30065", "name": "CHEBI:30065", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:168585", "map_id": "CHEBI:168585", "name": "CHEBI:168585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:171895", "map_id": "CHEBI:171895", "name": "CHEBI:171895", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28591", "map_id": "CHEBI:28591", "name": "CHEBI:28591", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:228987", "map_id": "pubchem.compound:228987", "name": "pubchem.compound:228987", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:48408", "map_id": "CHEBI:48408", "name": "CHEBI:48408", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17447", "map_id": "CHEBI:17447", "name": "CHEBI:17447", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:101330", "map_id": "pubchem.compound:101330", "name": "pubchem.compound:101330", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:61727", "map_id": "CHEBI:61727", "name": "CHEBI:61727", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:8144", "map_id": "pubchem.compound:8144", "name": "pubchem.compound:8144", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:181287", "map_id": "pubchem.compound:181287", "name": "pubchem.compound:181287", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": 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"sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6807616", "map_id": "CHEBI:422", "name": "LACT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:15399", "map_id": "CHEBI:15399", "name": "CHEBI:15399", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:92979", "map_id": "pubchem.compound:92979", "name": "pubchem.compound:92979", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:106997", "map_id": "pubchem.compound:106997", "name": "pubchem.compound:106997", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28235", "map_id": "CHEBI:28235", "name": "CHEBI:28235", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18346", "map_id": "CHEBI:18346", "name": "CHEBI:18346", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:76306", "map_id": "CHEBI:76306", "name": "CHEBI:76306", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34522", "map_id": "CHEBI:34522", "name": "CHEBI:34522", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:61052", "map_id": "pubchem.compound:61052", "name": "pubchem.compound:61052", "type": 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"map_id": "CHEBI:34037", "name": "CHEBI:34037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28857", "map_id": "CHEBI:28857", "name": "CHEBI:28857", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:67890", "map_id": "CHEBI:67890", "name": "CHEBI:67890", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:64805", "map_id": "pubchem.compound:64805", "name": "pubchem.compound:64805", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:167345", "map_id": "CHEBI:167345", "name": "CHEBI:167345", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28878", "map_id": "CHEBI:28878", "name": "CHEBI:28878", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:89886", "map_id": "CHEBI:89886", "name": "CHEBI:89886", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666113", "map_id": "none", "name": "odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10661541", "map_id": "none", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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}, { "id": "WBGene00000230", "map_id": "WBGene00000230", "name": "atp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXK1", "map_id": "Q9XXK1", "name": "atp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010419", "map_id": "WBGene00010419", "name": "atp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22021", "map_id": "Q22021", "name": "ATP5J2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011273", "map_id": "WBGene00011273", "name": "ATP5J2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17763", 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803785", "map_id": "none", "name": "GlcNAc, GlcNGc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:27459", "map_id": "CHEBI:27459", "name": "CHEBI:27459", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803738", "map_id": "none", "name": "GlcNAc-6-P, GlcNGc-6-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6803743", "map_id": "CHEBI:88130", "name": "GlcNGc-6-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_449703", "map_id": "CHEBI:15784", "name": "AcGlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655664", "map_id": "none", "name": "NAGK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23196", "map_id": "Q23196", "name": "NAGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021056", "map_id": "WBGene00021056", "name": "NAGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650281", "map_id": "none", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787618", "map_id": "CHEBI:16955", "name": "GDP-DHDMan", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787646", "map_id": "CHEBI:86476", "name": "GDP-KDGal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10650278", "map_id": "none", "name": "TSTA3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EER4", "map_id": "G5EER4", "name": "ger-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019813", "map_id": "WBGene00019813", "name": "ger-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641130", "map_id": "none", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419987", "map_id": "CHEBI:17407", "name": "E,E-FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4419982", "map_id": "CHEBI:37531", "name": "pPPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10641127", "map_id": "none", "name": "DHDDS:NUS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20118", "map_id": "Q20118", "name": "NUS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009505", "map_id": "WBGene00009505", "name": "NUS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5FC21", "map_id": "Q5FC21", "name": "DHDDS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044025", "map_id": "WBGene00044025", "name": "DHDDS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655675", "map_id": "none", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193473", "map_id": "CHEBI:16359", "name": "CCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655672", "map_id": "P34480", "name": "AMDHD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010308", "map_id": "WBGene00010308", "name": "AMDHD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650263", "map_id": "none", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650260", "map_id": "Q0PDK5", "name": "FPGT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00044903", "map_id": "WBGene00044903", "name": "FPGT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650289", "map_id": "none", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650286", "map_id": "Q18801", "name": "bre-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000266", "map_id": "WBGene00000266", "name": "bre-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622051", "map_id": "none", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532204", "map_id": "CHEBI:7125", "name": "AcGlcN1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622048", "map_id": "Q19680", "name": "PGM3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009006", "map_id": "WBGene00009006", "name": "PGM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622373", "map_id": "none", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622370", "map_id": "none", "name": "2xGNPNAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17427", "map_id": "Q17427", "name": "gna-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001646", "map_id": "WBGene00001646", "name": "gna-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641138", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10641135", "map_id": "Q17428", "name": "SRD5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007102", "map_id": "WBGene00007102", "name": "SRD5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622363", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622360", "map_id": "none", "name": "GFPT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19130", "map_id": "Q19130", "name": "gfat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008546", "map_id": "WBGene00008546", "name": "gfat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19699", "map_id": "Q19699", "name": "gfat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009035", "map_id": "WBGene00009035", "name": "gfat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622119", "map_id": "none", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622116", "map_id": "none", "name": "2xUAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18493", "map_id": "Q18493", "name": "UAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007965", "map_id": "WBGene00007965", "name": "UAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620242", "map_id": "none", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_428040", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428639", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428633", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620239", "map_id": "Q03567", "name": "SLC17A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00008000", "map_id": "WBGene00008000", "name": "SLC17A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650292", "map_id": "none", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10648046", "map_id": "none", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648040", "map_id": "Q95Q25", "name": "rad-51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004297", "map_id": "WBGene00004297", "name": "rad-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648043", "map_id": "Q95Q25", "name": "phospho-rad-51", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608272", "map_id": "Q9N3Z3", "name": "phospho-chk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000498", "map_id": "WBGene00000498", "name": "phospho-chk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625164", "map_id": "none", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10625161", "map_id": "G5EE46", "name": "D2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00010055", "map_id": "WBGene00010055", "name": "D2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113527", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880067", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10663595", "map_id": "none", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9012375", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10642260", "map_id": "Q21752", "name": "vdac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10599553", "map_id": "none", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599550", "map_id": "none", "name": "lipo-PDH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_8878387", "map_id": "CHEBI:58937", "name": "ThDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "O17953", "map_id": "O17953", "name": "dld-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010794", "map_id": "WBGene00010794", "name": "dld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52899", "map_id": "P52899", "name": "PDHA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011510", "map_id": "WBGene00011510", "name": "PDHA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19749", "map_id": "Q19749", "name": "dlat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009082", "map_id": "WBGene00009082", "name": "dlat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44451", "map_id": "O44451", "name": "pdhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015413", "map_id": "WBGene00015413", "name": "pdhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598689", "map_id": "none", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598686", "map_id": "none", "name": "LDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27888", "map_id": "Q27888", "name": "ldh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002262", "map_id": "WBGene00002262", "name": "ldh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599144", "map_id": "none", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599141", "map_id": "none", "name": "MDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02640", "map_id": "O02640", "name": "mdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003162", "map_id": "WBGene00003162", "name": "mdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10655838", "map_id": "none", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10655835", "map_id": "Q27888", "name": "ldh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10663592", "map_id": "none", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10663589", "map_id": "none", "name": "ME3:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U296", "map_id": "Q9U296", "name": "men-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012983", "map_id": "WBGene00012983", "name": "men-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625174", "map_id": "none", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_880013", "map_id": "CHEBI:32797", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10625171", "map_id": "Q9N4Z0", "name": "L2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00021564", "map_id": "WBGene00021564", "name": "L2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622718", "map_id": "none", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5462", "compartment_display": "mitochondrion" }, { "id": "species_10622715", "map_id": "none", "name": "NNT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q18031", "map_id": "Q18031", "name": "nnt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003778", "map_id": "WBGene00003778", "name": "nnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599198", "map_id": "none", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70958", "map_id": "CHEBI:57292", "name": "SUCC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599195", "map_id": "none", "name": "SUCLA2:SUCLG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P53596", "map_id": "P53596", "name": "sucl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007350", "map_id": "WBGene00007350", "name": "sucl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53588", "map_id": "P53588", "name": "suca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009812", "map_id": "WBGene00009812", "name": "suca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612583", "map_id": "none", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612567", "map_id": "none", "name": "p-lipo-PDH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10612572", "map_id": "Q02332", "name": "pdhk-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00022719", "map_id": "WBGene00022719", "name": "pdhk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612581", "map_id": "none", "name": "DCA:PDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_9010792", "map_id": "LigandDisplayForward?ligandId=4518", "name": "DCA", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "Q02332", "map_id": "Q02332", "name": "pdhk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599555", "map_id": "none", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599266", "map_id": "none", "name": "lipo-aKGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45148", "map_id": "O45148", "name": "dlst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020950", "map_id": "WBGene00020950", "name": "dlst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61199", "map_id": "O61199", "name": "ogdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020679", "map_id": "WBGene00020679", "name": "ogdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17460", "map_id": "CHEBI:17460", "name": "CHEBI:17460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649888", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649885", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXJ1", "map_id": "Q9XXJ1", "name": "HAGH-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012459", "map_id": "WBGene00012459", "name": "HAGH-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615570", "map_id": "none", "name": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_373863", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10612981", "map_id": "none", "name": "BSG:MCTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22109", "map_id": "Q22109", "name": "mct-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020168", "map_id": "WBGene00020168", "name": "mct-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17328", "map_id": "O17328", "name": "mct-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015676", "map_id": "WBGene00015676", "name": "mct-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAT3", "map_id": "Q9UAT3", "name": "mct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015273", "map_id": "WBGene00015273", "name": "mct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93896", "map_id": "Q93896", "name": "mct-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010834", "map_id": "WBGene00010834", "name": "mct-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18712", "map_id": "Q18712", "name": "gem-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008214", "map_id": "WBGene00008214", "name": "gem-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0E6", "map_id": "H2L0E6", "name": "mct-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003986", "map_id": "WBGene00003986", "name": "mct-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599832", "map_id": "none", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599829", "map_id": "none", "name": "SUCLG1:SUCLG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P53589", "map_id": "P53589", "name": "sucg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016844", "map_id": "WBGene00016844", "name": "sucg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622720", "map_id": "none", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599121", "map_id": "P34455", "name": "aco-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000041", "map_id": "WBGene00000041", "name": "aco-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622730", "map_id": "none", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10622727", "map_id": "none", "name": "IDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17643", "map_id": "O17643", "name": "idh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007942", "map_id": "WBGene00007942", "name": "idh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599154", "map_id": "none", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599151", "map_id": "none", "name": "FH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17214", "map_id": "O17214", "name": "fum-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001503", "map_id": "WBGene00001503", "name": "fum-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625156", "map_id": "none", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10625153", "map_id": "Q9U2M4", "name": "hphd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00012608", "map_id": "WBGene00012608", "name": "hphd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663519", "map_id": "none", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612574", "map_id": "Q02332", "name": "pdhk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10663554", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10663551", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34673", "map_id": "P34673", "name": "fahd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022798", "map_id": "WBGene00022798", "name": "fahd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599183", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599180", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q09508", "map_id": "Q09508", "name": "sdha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015391", "map_id": "WBGene00015391", "name": "sdha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62215", "map_id": "O62215", "name": "sdhd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009353", "map_id": "WBGene00009353", "name": "sdhd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41956", "map_id": "P41956", "name": "mev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003225", "map_id": "WBGene00003225", "name": "mev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09545", "map_id": "Q09545", "name": "sdhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006433", "map_id": "WBGene00006433", "name": "sdhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599134", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599131", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34575", "map_id": "P34575", "name": "cts-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000833", "map_id": "WBGene00000833", "name": "cts-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599116", "map_id": "none", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599113", "map_id": "none", "name": "IDH3 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q93353", "map_id": "Q93353", "name": "idhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007993", "map_id": "WBGene00007993", "name": "idhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20049", "map_id": "Q20049", "name": "idhg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009440", "map_id": "WBGene00009440", "name": "idhg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93714", "map_id": "Q93714", "name": "idha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009664", "map_id": "WBGene00009664", "name": "idha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663526", "map_id": "none", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10663523", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10663568", "map_id": "none", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663565", "map_id": "none", "name": "ME1:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599872", "map_id": "none", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10629160", "map_id": "none", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629157", "map_id": "none", "name": "MTAP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09438", "map_id": "Q09438", "name": "MTAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015064", "map_id": "WBGene00015064", "name": "MTAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629140", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629137", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20340", "map_id": "Q20340", "name": "ADI1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009636", "map_id": "WBGene00009636", "name": "ADI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630115", "map_id": "none", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629127", "map_id": "Q93169", "name": "MRI1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007236", "map_id": "WBGene00007236", "name": "MRI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629150", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10629147", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21012", "map_id": "Q21012", "name": "ENOPH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010286", "map_id": "WBGene00010286", "name": "ENOPH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607469", "map_id": "none", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10607114", "map_id": "none", "name": "UCP dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O01883", "map_id": "O01883", "name": "ucp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006729", "map_id": "WBGene00006729", "name": "ucp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30495", "map_id": "CHEBI:15904", "name": "LCFA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_170037", "map_id": "none", "name": "Purine nucleotide", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607123", "map_id": "none", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_166213", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-in\"", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10607116", "map_id": "none", "name": "FA anion:UCP dimer \"head-in\" complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_166216", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-out\"", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10607125", "map_id": "none", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10607118", "map_id": "none", "name": "FA anion:UCP dimer \"head-out\" complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10607121", "map_id": "none", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10660441", "map_id": "none", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607861", "map_id": "none", "name": "p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660439", "map_id": "none", "name": "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660437", "map_id": "none", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660433", "map_id": "V6CLN5", "name": "zfh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022518", "map_id": "WBGene00022518", "name": "zfh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660435", "map_id": "none", "name": "RUNX3:ZFHX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "V6CLN5", "map_id": "V6CLN5", "name": "zfh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648407", "map_id": "none", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5690520", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_164991", "map_id": "CHEBI:33184", "name": "LCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690542", "map_id": "CHEBI:61907", "name": "MCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690539", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690531", "map_id": "CHEBI:59554", "name": "MCFA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10648404", "map_id": "none", "name": "ACOT4,6,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "B3WFZ3", "map_id": "B3WFZ3", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020989", "map_id": "WBGene00020989", "name": "ACOT2(1-483)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45003", "map_id": "O45003", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIA9", "map_id": "Q9BIA9", "name": "ACOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01862", "map_id": "O01862", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYN3", "map_id": "Q9GYN3", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617868", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617420", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "O45730", "map_id": "O45730", "name": "pmp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617695", "map_id": "none", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389596", "map_id": "CHEBI:16285", "name": "Phytanate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389573", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389620", "map_id": "CHEBI:456215", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389593", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389615", "map_id": "CHEBI:15538", "name": "Phytanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617692", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10617827", "map_id": "none", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10617818", "map_id": "none", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10656361", "map_id": "none", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10656355", "map_id": "O17761", "name": "ech-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00001157", "map_id": "WBGene00001157", "name": "ech-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617816", "map_id": "none", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10657324", "map_id": "none", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10657320", "map_id": "none", "name": "ACBD5,(ACBD4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q20507", "map_id": "Q20507", "name": "acbp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009818", "map_id": "WBGene00009818", "name": "acbp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20862", "map_id": "Q20862", "name": "acbp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018949", "map_id": "WBGene00018949", "name": "acbp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657322", "map_id": "none", "name": "ACBD4,5:LCFA-CoA, MCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10617708", "map_id": "none", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389537", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389594", "map_id": "CHEBI:15475", "name": "3S2HPhy-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389583", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617705", "map_id": "none", "name": "PHYH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O62515", "map_id": "O62515", "name": "PHYH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014000", "map_id": "WBGene00014000", "name": "PHYH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617674", "map_id": "none", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617671", "map_id": "none", "name": "ALDH3A2-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10627078", "map_id": "none", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_977323", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10627075", "map_id": "Q20048", "name": "mlcd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00009439", "map_id": "WBGene00009439", "name": "mlcd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656358", "map_id": "none", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10617698", "map_id": "none", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10617686", "map_id": "none", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389578", "map_id": "CHEBI:15522", "name": "FOR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617683", "map_id": "none", "name": "HACL1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q17474", "map_id": "Q17474", "name": "HACL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007143", "map_id": "WBGene00007143", "name": "HACL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650299", "map_id": "none", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6787810", "map_id": "CHEBI:65101", "name": "2OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6787814", "map_id": "CHEBI:86988", "name": "2oxo-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10650296", "map_id": "none", "name": "HAO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "B1GRK5", "map_id": "B1GRK5", "name": "HAO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018286", "map_id": "WBGene00018286", "name": "HAO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656540", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10656537", "map_id": "P91148", "name": "ndx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00003584", "map_id": "WBGene00003584", "name": "ndx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613435", "map_id": "none", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613331", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613333", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613439", "map_id": "none", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610461", "map_id": "none", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607264", "map_id": "Q8WQG9", "name": "phospho-jnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10620307", "map_id": "none", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620302", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620304", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620381", "map_id": "none", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620376", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620378", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641401", "map_id": "none", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641391", "map_id": "P34534", "name": "TOP2A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00019884", "map_id": "WBGene00019884", "name": "SUMO1-K-TOP2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641399", "map_id": "none", "name": "SUMO1:TOP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34534", "map_id": "P34534", "name": "SUMO1-K-TOP2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641432", "map_id": "none", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641415", "map_id": "none", "name": "Homologues of TOP2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ECQ8", "map_id": "G5ECQ8", "name": "cin-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022854", "map_id": "WBGene00022854", "name": "cin-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23670", "map_id": "Q23670", "name": "top-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010785", "map_id": "WBGene00010785", "name": "top-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641430", "map_id": "none", "name": "SUMO1:TOP2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641275", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641264", "map_id": "O45012", "name": "nol-58", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641273", "map_id": "none", "name": "2SUMO1:NOP58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638087", "map_id": "none", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10642632", "map_id": "none", "name": "RANBP2 SUMOylates PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638311", "map_id": "none", "name": "3SUMO1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2L0K3", "map_id": "H2L0K3", "name": "nhl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641447", "map_id": "none", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641437", "map_id": "O17966", "name": "top-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006595", "map_id": "WBGene00006595", "name": "top-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641445", "map_id": "none", "name": "SUMO1:TOP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17966", "map_id": "O17966", "name": "top-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638321", "map_id": "none", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638318", "map_id": "none", "name": "UBE2I,HDAC7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641361", "map_id": "none", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10598194", "map_id": "O02115", "name": "pcn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10641359", "map_id": "none", "name": "SUMO1:PCNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10640956", "map_id": "none", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640954", "map_id": "none", "name": "SUMO1:K14-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10640528", "map_id": "none", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640526", "map_id": "none", "name": "2SUMO1:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10641199", "map_id": "none", "name": "RANBP2 SUMOylates RANBP2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10641186", "map_id": "Q86G90", "name": "npp-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10641196", "map_id": "none", "name": "3SUMO1:RANBP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10638341", "map_id": "none", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10638328", "map_id": "none", "name": "RANGAP1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "P34342", "map_id": "P34342", "name": "ran-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004303", "map_id": "WBGene00004303", "name": "ran-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638338", "map_id": "none", "name": "SUMO1:RANGAP1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10641300", "map_id": "none", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641290", "map_id": "Q9N4C3", "name": "xpc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022296", "map_id": "WBGene00022296", "name": "xpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641298", "map_id": "none", "name": "SUMO1:XPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N4C3", "map_id": "Q9N4C3", "name": "xpc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640543", "map_id": "none", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640533", "map_id": "Q9XUW5", "name": "ddx-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00010260", "map_id": "WBGene00010260", "name": "ddx-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640541", "map_id": "none", "name": "SUMO1:DDX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XUW5", "map_id": "Q9XUW5", "name": "ddx-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640987", "map_id": "none", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10640977", "map_id": "Q8MQ70", "name": "hpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001994", "map_id": "WBGene00001994", "name": "hpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640985", "map_id": "none", "name": "SUMO1:HIPK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MQ70", "map_id": "Q8MQ70", "name": "hpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638449", "map_id": "none", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636923", "map_id": "none", "name": "Cohesin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638413", "map_id": "none", "name": "SUMOylated Cohesin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10638446", "map_id": "none", "name": "SMC5-SMC6 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XTV3", "map_id": "Q9XTV3", "name": "EID3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010409", "map_id": "WBGene00010409", "name": "EID3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91501", "map_id": "P91501", "name": "NSMCE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020843", "map_id": "WBGene00020843", "name": "NSMCE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23420", "map_id": "Q23420", "name": "NSMCE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022881", "map_id": "WBGene00022881", "name": "NSMCE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18237", "map_id": "Q18237", "name": "smc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016151", "map_id": "WBGene00016151", "name": "smc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG17", "map_id": "G5EG17", "name": "smc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010056", "map_id": "WBGene00010056", "name": "smc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641326", "map_id": "none", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641324", "map_id": "none", "name": "Homologues of ub-PRICKLE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYA1", "map_id": "H2KYA1", "name": "prkl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022727", "map_id": "WBGene00022727", "name": "prkl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZA3", "map_id": "H2KZA3", "name": "pqn-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004112", "map_id": "WBGene00004112", "name": "pqn-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640476", "map_id": "none", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640470", "map_id": "none", "name": "RAC:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640474", "map_id": "none", "name": "pp-DVL:RAC:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641973", "map_id": "none", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10641961", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10641971", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10641907", "map_id": "none", "name": "clathrin:AP-2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641915", "map_id": "none", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612022", "map_id": "none", "name": "Homologues of DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10641880", "map_id": "none", "name": "N4GlycoAsn-PalmS-WNT5A:FZD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10641884", "map_id": "none", "name": "WNT5A:FZD4:DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641963", "map_id": "none", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10639064", "map_id": "P34889", "name": "cwn-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10641959", "map_id": "none", "name": "FZD2/FZD5/ROR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641878", "map_id": "none", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10641874", "map_id": "none", "name": "WNT5A-binding FZDs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10641876", "map_id": "none", "name": "WNT5A:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641891", "map_id": "none", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10641886", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10641888", "map_id": "none", "name": "Activated Protein kinase C (alpha, beta, gamma isoforms)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641913", "map_id": "none", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618761", "map_id": "P51485", "name": "arr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10641911", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640492", "map_id": "none", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640488", "map_id": "none", "name": "p-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640486", "map_id": "none", "name": "WNT:FZD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34888", "map_id": "P34888", "name": "cwn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000857", "map_id": "WBGene00000857", "name": "cwn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640490", "map_id": "none", "name": "WNT:FZD:pDVL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10641957", "map_id": "none", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10641955", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10641882", "map_id": "none", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640846", "map_id": "Q9N532", "name": "mig-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10660033", "map_id": "none", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10657991", "map_id": "Q23165", "name": "apt-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00000166", "map_id": "WBGene00000166", "name": "apt-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658032", "map_id": "none", "name": "ARF6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q9U2S4", "map_id": "Q9U2S4", "name": "arf-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000184", "map_id": "WBGene00000184", "name": "arf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660031", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q23165", "map_id": "Q23165", "name": "apt-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643599", "map_id": "none", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10643587", "map_id": "none", "name": "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01768", "map_id": "O01768", "name": "phospho-lrp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003072", "map_id": "WBGene00003072", "name": "phospho-lrp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643597", "map_id": "none", "name": "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10631246", "map_id": "none", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611990", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611940", "map_id": "none", "name": "GSK3B:AXIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611992", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL:AXIN:GSK3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612002", "map_id": "none", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611999", "map_id": "none", "name": "WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10603107", "map_id": "none", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602942", "map_id": "none", "name": "pol II closed pre-initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604747", "map_id": "none", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603821", "map_id": "none", "name": "pol II transcription complex containing 11 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603858", "map_id": "none", "name": "Pol II transcription complex containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10599973", "map_id": "none", "name": "RNA Polymerase II (unphosphorylated):TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664877", "map_id": "none", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602904", "map_id": "none", "name": "pol II transcription complex containing 3 Nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603823", "map_id": "none", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602967", "map_id": "none", "name": "pol II transcription complex containing 9 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602969", "map_id": "none", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602952", "map_id": "none", "name": "pol II transcription complex containing 4 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602053", "map_id": "none", "name": "TFIID", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602065", "map_id": "none", "name": "TFIIE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601970", "map_id": "none", "name": "TFIIA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602954", "map_id": "none", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601975", "map_id": "O16991", "name": "ttb-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10664879", "map_id": "none", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10602907", "map_id": "none", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10598407", "map_id": "none", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598404", "map_id": "none", "name": "PGM:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639536", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639531", "map_id": "none", "name": "GYG2:GYS2-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2D9", "map_id": "Q9U2D9", "name": "phospho-gsy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001793", "map_id": "WBGene00001793", "name": "phospho-gsy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYQ5", "map_id": "H2KYQ5", "name": "gyg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006863", "map_id": "WBGene00006863", "name": "gyg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639533", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640276", "map_id": "none", "name": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640268", "map_id": "none", "name": "PPP1R3C:glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q966L7", "map_id": "Q966L7", "name": "PPP1R3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019211", "map_id": "WBGene00019211", "name": "PPP1R3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYT5", "map_id": "H2KYT5", "name": "PPP1R3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640273", "map_id": "none", "name": "PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640292", "map_id": "none", "name": "PPP1R3C binds to glycogen:GYG2:GYS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639518", "map_id": "none", "name": "glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640266", "map_id": "none", "name": "Homologues of PPP1R3C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665117", "map_id": "none", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665114", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639526", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639508", "map_id": "none", "name": "polyGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10639523", "map_id": "Q22137", "name": "GBE1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011409", "map_id": "WBGene00011409", "name": "GBE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639511", "map_id": "none", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639506", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640297", "map_id": "none", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640294", "map_id": "none", "name": "EPM2A:PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640282", "map_id": "none", "name": "EPM2A:PPP1R3C:glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639516", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639513", "map_id": "none", "name": "GYG2:GYS2-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10648882", "map_id": "none", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10648879", "map_id": "none", "name": "Homologues of HSD17B11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666026", "map_id": "none", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666023", "map_id": "none", "name": "Homologues of SRD5A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20344", "map_id": "Q20344", "name": "SRD5A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009635", "map_id": "WBGene00009635", "name": "SRD5A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23431", "map_id": "Q23431", "name": "SRD5A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014241", "map_id": "WBGene00014241", "name": "SRD5A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19605", "map_id": "Q19605", "name": "SRD5A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610423", "map_id": "none", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661727", "map_id": "none", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8951853", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_193156", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10661724", "map_id": "none", "name": "TSPO:BZRAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "C7FZU5", "map_id": "C7FZU5", "name": "tspo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077771", "map_id": "WBGene00077771", "name": "tspo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610421", "map_id": "none", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610416", "map_id": "Q10130", "name": "dhs-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10622873", "map_id": "none", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622870", "map_id": "none", "name": "Homologues of SRD5A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10630301", "map_id": "none", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10630297", "map_id": "none", "name": "Homologues of SERPINA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_1449707", "map_id": "none", "name": "Corticosteroids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:27584", "map_id": "CHEBI:27584", "name": "CHEBI:27584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17026", "map_id": "CHEBI:17026", "name": "CHEBI:17026", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16973", "map_id": "CHEBI:16973", "name": "CHEBI:16973", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17650", "map_id": "CHEBI:17650", "name": "CHEBI:17650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630299", "map_id": "none", "name": "CBG:Corticosteroids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10649574", "map_id": "none", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696835", "map_id": "CHEBI:16469", "name": "EST17b", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696848", "map_id": "CHEBI:17263", "name": "E1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649571", "map_id": "none", "name": "Homologues of AKR1B15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10610735", "map_id": "none", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196095", "map_id": "CHEBI:17998", "name": "ISCAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196066", "map_id": "CHEBI:63910", "name": "MePeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610732", "map_id": "none", "name": "Homologues of AKR1B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666029", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10659973", "map_id": "none", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659970", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2:CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659935", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2:p-Y-CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666213", "map_id": "none", "name": "Anti-MET recombinant therapeutic antibodies bind MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10618556", "map_id": "Q9XVQ7", "name": "MET", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_9734118", "map_id": "none", "name": "Anti-MET MAbs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "map_id": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "name": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7748", "map_id": "LigandDisplayForward?ligandId=7748", "name": "LigandDisplayForward?ligandId=7748", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8966", "map_id": "LigandDisplayForward?ligandId=8966", "name": "LigandDisplayForward?ligandId=8966", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "map_id": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "name": "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666211", "map_id": "none", "name": "Anti-MET MAbs:MET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659977", "map_id": "none", "name": "CBL recruits CIN85:endophilin to ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659944", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659975", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659981", "map_id": "none", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659979", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659947", "map_id": "none", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10604651", "map_id": "none", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604647", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604634", "map_id": "Q09615", "name": "rev-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00014066", "map_id": "WBGene00014066", "name": "rev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604649", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09615", "map_id": "Q09615", "name": "rev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604660", "map_id": "none", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604657", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10610473", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193745", "map_id": "CHEBI:63839", "name": "4CHOL7a,12a,24(S)TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193707", "map_id": "CHEBI:63830", "name": "5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610230", "map_id": "none", "name": "Homologues of AKR1D1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610467", "map_id": "none", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193732", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610455", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193403", "map_id": "CHEBI:28533", "name": "3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10606370", "map_id": "none", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194069", "map_id": "none", "name": "Gly, TAU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15891", "map_id": "CHEBI:15891", "name": "CHEBI:15891", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_194073", "map_id": "none", "name": "choloyl-CoA; chenodeoxycholoyl-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_192356", "map_id": "CHEBI:15519", "name": "choloyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193472", "map_id": "CHEBI:28701", "name": "chenodeoxycholoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193416", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10606367", "map_id": "none", "name": "Homologues of BAAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659836", "map_id": "none", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659832", "map_id": "Q21130", "name": "STARD5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010505", "map_id": "WBGene00010505", "name": "STARD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659834", "map_id": "none", "name": "STARD5:DCA,LCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21130", "map_id": "Q21130", "name": "STARD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610485", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9617026", "map_id": "CHEBI:48833", "name": "4CHOL7a,12a,27TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193829", "map_id": "CHEBI:48834", "name": "5beta-cholestan-7alpha,12alpha,27-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610446", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193505", "map_id": "CHEBI:16577", "name": "DHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193457", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610439", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10610547", "map_id": "none", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610544", "map_id": "Q3S1M2", "name": "mrp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003407", "map_id": "WBGene00003407", "name": "mrp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610453", "map_id": "none", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193463", "map_id": "none", "name": "Gly, TAU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_193453", "map_id": "none", "name": "chenodeoxycholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_10610274", "map_id": "none", "name": "Homologues of BAAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10610260", "map_id": "none", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192195", "map_id": "CHEBI:28477", "name": "4CHOL7a,12aDONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_192064", "map_id": "CHEBI:2288", "name": "5beta-cholesten-7alpha, 12alpha-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610277", "map_id": "none", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193404", "map_id": "none", "name": "cholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10610465", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193762", "map_id": "CHEBI:63824", "name": "TetraHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193741", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10666209", "map_id": "none", "name": "Bile salts bind FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643137", "map_id": "none", "name": "Homologues of FABP6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10666205", "map_id": "none", "name": "bile salts and acids:FABP6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610287", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192342", "map_id": "CHEBI:27505", "name": "THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193422", "map_id": "CHEBI:52050", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10666207", "map_id": "none", "name": "Bile salts dissociate from FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610477", "map_id": "none", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193793", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610489", "map_id": "none", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193830", "map_id": "CHEBI:48778", "name": "5beta-cholestan-7alpha,27-diol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193842", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610247", "map_id": "none", "name": "Homologues of AKR1C4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610433", "map_id": "none", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10610483", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193843", "map_id": "CHEBI:17278", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610463", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193778", "map_id": "CHEBI:48736", "name": "3,7,24THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193739", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10606342", "map_id": "none", "name": "Homologues of SLC27A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10610324", "map_id": "none", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192316", "map_id": "CHEBI:37643", "name": "25(S) THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10659235", "map_id": "none", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8868393", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10659232", "map_id": "A7DTF2", "name": "obr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012930", "map_id": "WBGene00012930", "name": "obr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606345", "map_id": "none", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194096", "map_id": "none", "name": "CCA,CDCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659112", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10659109", "map_id": "none", "name": "OSBPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93485", "map_id": "Q93485", "name": "obr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008832", "map_id": "WBGene00008832", "name": "obr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01686", "map_id": "O01686", "name": "obr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016331", "map_id": "WBGene00016331", "name": "obr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610262", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192013", "map_id": "CHEBI:18402", "name": "THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192096", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610425", "map_id": "none", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193442", "map_id": "CHEBI:15494", "name": "25(S) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193459", "map_id": "CHEBI:27393", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610475", "map_id": "none", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193760", "map_id": "CHEBI:63829", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_213285", "map_id": "CHEBI:63831", "name": "5beta-cholestan-3alpha,7alpha,24(S)-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610457", "map_id": "none", "name": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10610528", "map_id": "none", "name": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610525", "map_id": "Q33BL1", "name": "SLC10A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00044650", "map_id": "WBGene00044650", "name": "SLC10A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610469", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610258", "map_id": "none", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192308", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610459", "map_id": "none", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10610451", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192339", "map_id": "CHEBI:27379", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610479", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610448", "map_id": "none", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193429", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10610233", "map_id": "none", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192136", "map_id": "CHEBI:17899", "name": "4CHOL7aOLONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_191980", "map_id": "CHEBI:2290", "name": "5beta-cholestan-7alpha-ol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610471", "map_id": "none", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193724", "map_id": "CHEBI:63838", "name": "4CHOL7a,24(S)DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10610332", "map_id": "none", "name": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10610487", "map_id": "none", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193835", "map_id": "CHEBI:48825", "name": "4CHOL7a,27DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10610481", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193728", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610552", "map_id": "none", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10610549", "map_id": "Q33BL1", "name": "SLC10A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10610264", "map_id": "none", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192030", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha,7alpha-diol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610442", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10643250", "map_id": "none", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5340249", "map_id": "none", "name": "DCA,CDCA,LCHA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10616320", "map_id": "none", "name": "Homologues of NR1H4-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10643248", "map_id": "none", "name": "NR1H4:DCA,CDCA,LCHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10610198", "map_id": "none", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192148", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610195", "map_id": "none", "name": "CH25H (Fe2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20027", "map_id": "Q20027", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018036", "map_id": "WBGene00018036", "name": "CH25H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610250", "map_id": "none", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192087", "map_id": "CHEBI:16496", "name": "5beta-cholestan-3alpha,7alpha,12alpha-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610444", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10614222", "map_id": "none", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10614220", "map_id": "none", "name": "active caspase-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614879", "map_id": "none", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614875", "map_id": "none", "name": "HMGB1/HMGB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10614877", "map_id": "none", "name": "HMGB1/HMGB2- bound chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665078", "map_id": "none", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665063", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19266", "map_id": "Q19266", "name": "phospho-pkc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665076", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10649463", "map_id": "none", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5362565", "map_id": "CHEBI:78273", "name": "9cRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5362520", "map_id": "CHEBI:50648", "name": "9cRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649460", "map_id": "Q18822", "name": "alh-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000116", "map_id": "WBGene00000116", "name": "alh-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665073", "map_id": "none", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10665069", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10665071", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607578", "map_id": "Q23089", "name": "xpo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00002078", "map_id": "WBGene00002078", "name": "xpo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611037", "map_id": "none", "name": "p-Y185,Y187 MAPK1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661072", "map_id": "none", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1254400", "map_id": "CHEBI:50114", "name": "ESTG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10661060", "map_id": "none", "name": "ESR1:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NES8", "map_id": "Q9NES8", "name": "pph-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012665", "map_id": "WBGene00012665", "name": "pph-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09637", "map_id": "Q09637", "name": "cyn-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000885", "map_id": "WBGene00000885", "name": "cyn-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661062", "map_id": "none", "name": "ESTG:ESR1:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664151", "map_id": "none", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10664147", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17381", "map_id": "Q17381", "name": "pha-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004013", "map_id": "WBGene00004013", "name": "pha-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF71", "map_id": "G5EF71", "name": "med-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003180", "map_id": "WBGene00003180", "name": "med-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7WN96", "map_id": "B7WN96", "name": "elt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001251", "map_id": "WBGene00001251", "name": "elt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUW7", "map_id": "Q9XUW7", "name": "end-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001311", "map_id": "WBGene00001311", "name": "end-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2X0", "map_id": "Q9U2X0", "name": "prmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28515", "map_id": "P28515", "name": "elt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001249", "map_id": "WBGene00001249", "name": "elt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:142773", "map_id": "CHEBI:142773", "name": "CHEBI:142773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21187", "map_id": "Q21187", "name": "fkh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001441", "map_id": "WBGene00001441", "name": "fkh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27974", "map_id": "CHEBI:27974", "name": "CHEBI:27974", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664133", "map_id": "none", "name": "histone acetyltransferases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TYU5", "map_id": "Q9TYU5", "name": "mys-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007029", "map_id": "WBGene00007029", "name": "mys-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664149", "map_id": "none", "name": "ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611449", "map_id": "none", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_549207", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_201034", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10611446", "map_id": "none", "name": "CPT1A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9U2F2", "map_id": "Q9U2F2", "name": "cpt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012907", "map_id": "WBGene00012907", "name": "cpt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23066", "map_id": "Q23066", "name": "cpt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020911", "map_id": "WBGene00020911", "name": "cpt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16992", "map_id": "O16992", "name": "CPT1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021002", "map_id": "WBGene00021002", "name": "CPT1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG54", "map_id": "G5EG54", "name": "cpt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008629", "map_id": "WBGene00008629", "name": "cpt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3N3", "map_id": "Q9N3N3", "name": "cpt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021703", "map_id": "WBGene00021703", "name": "cpt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44619", "map_id": "O44619", "name": "cpt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019644", "map_id": "WBGene00019644", "name": "cpt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643512", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643509", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O01758", "map_id": "O01758", "name": "dhs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000966", "map_id": "WBGene00000966", "name": "dhs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16881", "map_id": "O16881", "name": "dhs-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000979", "map_id": "WBGene00000979", "name": "dhs-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20840", "map_id": "Q20840", "name": "drd-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018885", "map_id": "WBGene00018885", "name": "drd-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20012", "map_id": "Q20012", "name": "dhs-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000983", "map_id": "WBGene00000983", "name": "dhs-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663480", "map_id": "none", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649873", "map_id": "none", "name": "Homologues of GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10663476", "map_id": "none", "name": "Homologues of FOXA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10663464", "map_id": "none", "name": "CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P45972", "map_id": "P45972", "name": "ztf-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011639", "map_id": "WBGene00011639", "name": "ztf-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663462", "map_id": "P45972", "name": "ztf-17", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10663478", "map_id": "none", "name": "CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10644649", "map_id": "none", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10665002", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10644961", "map_id": "none", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10643550", "map_id": "none", "name": "Homologues of SUMO-K-CRABP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10643552", "map_id": "none", "name": "SUMO-CRABP1:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665085", "map_id": "none", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665080", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665066", "map_id": "none", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665058", "map_id": "none", "name": "PDPK1:PIP3:p-T410-PRKCZ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666083", "map_id": "none", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661066", "map_id": "none", "name": "ESR2:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661068", "map_id": "none", "name": "ESTG:ESR2:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612137", "map_id": "none", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612134", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_5693375", "map_id": "CHEBI:25682", "name": "ADMA", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10645853", "map_id": "none", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643186", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645851", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643570", "map_id": "none", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_32737", "map_id": "CHEBI:16066", "name": "11cRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643567", "map_id": "none", "name": "Homologues of RDH5(24-318)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10643188", "map_id": "none", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643184", "map_id": "none", "name": "Homologues of SUMO-K102-CRABP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10643631", "map_id": "none", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643628", "map_id": "none", "name": "RDH11,14,DHRS3,DHRS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EET7", "map_id": "G5EET7", "name": "RDH14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011940", "map_id": "WBGene00011940", "name": "RDH14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGA6", "map_id": "G5EGA6", "name": "dhrs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010063", "map_id": "WBGene00010063", "name": "dhrs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1XFZ3", "map_id": "Q1XFZ3", "name": "dhs-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000980", "map_id": "WBGene00000980", "name": "dhs-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663581", "map_id": "none", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10663576", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10663578", "map_id": "none", "name": "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643557", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643554", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17335", "map_id": "Q17335", "name": "ADH1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019240", "map_id": "WBGene00019240", "name": "ADH1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644959", "map_id": "none", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644957", "map_id": "none", "name": "FABP5:atRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665037", "map_id": "none", "name": "PTK2 binds activated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665035", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR:PTK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665042", "map_id": "none", "name": "PTK2 autophosphorylates downstream of EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665039", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643533", "map_id": "none", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643530", "map_id": "none", "name": "ALDH1A1,2,3 tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20780", "map_id": "Q20780", "name": "alh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000107", "map_id": "WBGene00000107", "name": "alh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXM0", "map_id": "Q9TXM0", "name": "alh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000108", "map_id": "WBGene00000108", "name": "alh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645837", "map_id": "none", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10645835", "map_id": "none", "name": "FABP5:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665044", "map_id": "none", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10645083", "map_id": "none", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_5623644", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623650", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10645080", "map_id": "Q9U1Y6", "name": "dhs-24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00000987", "map_id": "WBGene00000987", "name": "dhs-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665082", "map_id": "none", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607884", "map_id": "none", "name": "p-T185,Y187 MAPK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633165", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10633162", "map_id": "none", "name": "ARF1/3:GTP:PI4KB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q20077", "map_id": "Q20077", "name": "pifk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018076", "map_id": "WBGene00018076", "name": "pifk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633271", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806159", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10633268", "map_id": "Q93641", "name": "sac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00009264", "map_id": "WBGene00009264", "name": "sac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633120", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10633117", "map_id": "O17590", "name": "ocrl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007620", "map_id": "WBGene00007620", "name": "ocrl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633297", "map_id": "none", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10633160", "map_id": "none", "name": "ARF1/3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10633295", "map_id": "Q20077", "name": "pifk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10633321", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10633318", "map_id": "none", "name": "PI4KA/2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23083", "map_id": "Q23083", "name": "PI4K2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022501", "map_id": "WBGene00022501", "name": "PI4K2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW63", "map_id": "Q9XW63", "name": "PI4KA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013557", "map_id": "WBGene00013557", "name": "PI4KA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45318", "map_id": "O45318", "name": "PI4K2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633208", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10633184", "map_id": "none", "name": "PIK3C2A/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDY0", "map_id": "G5EDY0", "name": "piki-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009552", "map_id": "WBGene00009552", "name": "piki-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633279", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10633176", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806230", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10633173", "map_id": "none", "name": "PIK3C2A/G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666348", "map_id": "none", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597806", "map_id": "none", "name": "MCM2:MCM4:MCM6:MCM7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597692", "map_id": "none", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597686", "map_id": "none", "name": "ORC(2-5)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597678", "map_id": "none", "name": "ORC1:origin of replication", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597690", "map_id": "none", "name": "ORC(1-5):origin of replication", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10666265", "map_id": "none", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597818", "map_id": "none", "name": "MCM3:MCM5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10666223", "map_id": "none", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666221", "map_id": "Q9XX17", "name": "orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597674", "map_id": "Q9XX17", "name": "orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10666346", "map_id": "none", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597797", "map_id": "P34647", "name": "mcm-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597792", "map_id": "Q95XQ8", "name": "mcm-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597802", "map_id": "O16297", "name": "mcm-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10666344", "map_id": "none", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10666263", "map_id": "none", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10666259", "map_id": "none", "name": "H4K20Me2-nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10666261", "map_id": "none", "name": "ORC1:H4K20Me2-nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612074", "map_id": "none", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612026", "map_id": "none", "name": "DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612049", "map_id": "none", "name": "p-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640242", "map_id": "none", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611988", "map_id": "none", "name": "pp-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640239", "map_id": "Q20471", "name": "kin-20", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002203", "map_id": "WBGene00002203", "name": "kin-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640245", "map_id": "none", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640232", "map_id": "none", "name": "ppDVL:PIP5K1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01759", "map_id": "O01759", "name": "ppk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640234", "map_id": "none", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633032", "map_id": "O01759", "name": "ppk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605873", "map_id": "none", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605860", "map_id": "Q8MQ03", "name": "zen-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605864", "map_id": "Q8MQ03", "name": "phospho-zen-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10637119", "map_id": "none", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637115", "map_id": "none", "name": "Condensin I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFJ4", "map_id": "G5EFJ4", "name": "capg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009254", "map_id": "WBGene00009254", "name": "capg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2M1", "map_id": "Q9U2M1", "name": "dpy-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001087", "map_id": "WBGene00001087", "name": "dpy-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637105", "map_id": "none", "name": "CK2 Phosphorylated Condensin I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665030", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10665018", "map_id": "none", "name": "RAN:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17915", "map_id": "O17915", "name": "ran-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004302", "map_id": "WBGene00004302", "name": "ran-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665028", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10664962", "map_id": "none", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602699", "map_id": "none", "name": "Homologues of POM121", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10664958", "map_id": "none", "name": "Nup107-160 complex:AHCTF1:Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664960", "map_id": "none", "name": "POM121:Nup107-160 complex:AHCTF1:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10636865", "map_id": "none", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10636850", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10636862", "map_id": "none", "name": "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10607612", "map_id": "Q9N2L7", "name": "plk-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665723", "map_id": "none", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10665704", "map_id": "Q9U2M8", "name": "CC2D1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "WBGene00012578", "map_id": "WBGene00012578", "name": "CC2D1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665708", "map_id": "none", "name": "LEMD2:ESCRT-III:IST1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10665710", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9U2M8", "map_id": "Q9U2M8", "name": "CC2D1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636955", "map_id": "none", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10636925", "map_id": "G5EC05", "name": "evl-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636929", "map_id": "H2L0H5", "name": "wapl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10636931", "map_id": "none", "name": "Cohesin:PDS5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665026", "map_id": "none", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10649915", "map_id": "none", "name": "RAN:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665023", "map_id": "Q18211", "name": "ran-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "WBGene00004304", "map_id": "WBGene00004304", "name": "ran-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665033", "map_id": "none", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624890", "map_id": "none", "name": "Fused nuclear envelope vesicles", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10638249", "map_id": "none", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638243", "map_id": "Q19848", "name": "vrk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638238", "map_id": "H2KZB2", "name": "lem-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021945", "map_id": "WBGene00021945", "name": "lem-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638247", "map_id": "none", "name": "ANKLE2:VRK1/VRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "H2KZB2", "map_id": "H2KZB2", "name": "lem-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665721", "map_id": "none", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665712", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q8MNV0", "map_id": "Q8MNV0", "name": "spas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016045", "map_id": "WBGene00016045", "name": "spas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665717", "map_id": "Q9BL83", "name": "vps-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021334", "map_id": "WBGene00021334", "name": "vps-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665719", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9BL83", "map_id": "Q9BL83", "name": "vps-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636984", "map_id": "none", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_2537690", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "species_10636976", "map_id": "none", "name": "NIPBL:MAU2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95XZ5", "map_id": "Q95XZ5", "name": "scc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004166", "map_id": "WBGene00004166", "name": "scc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17581", "map_id": "O17581", "name": "mau-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003136", "map_id": "WBGene00003136", "name": "mau-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636982", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665725", "map_id": "none", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665699", "map_id": "Q8MNV0", "name": "spas-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665728", "map_id": "none", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616987", "map_id": "none", "name": "alpha-beta tubulin dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10636891", "map_id": "none", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636880", "map_id": "G5ED39", "name": "sep-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004775", "map_id": "WBGene00004775", "name": "sep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636888", "map_id": "none", "name": "ESPL1 Autocleaved", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED39", "map_id": "G5ED39", "name": "sep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636964", "map_id": "none", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10636961", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "reaction_10637117", "map_id": "none", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2529006", "map_id": "none", "name": "Unknown Phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605887", "map_id": "none", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605878", "map_id": "G5EE74", "name": "nud-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003829", "map_id": "WBGene00003829", "name": "phospho-nud-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605882", "map_id": "G5EE74", "name": "phospho-nud-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605884", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665692", "map_id": "none", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625894", "map_id": "none", "name": "PP2A (Aalpha:B55alpha:Calpha)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665690", "map_id": "none", "name": "ANKLE2:PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10662392", "map_id": "none", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10662092", "map_id": "none", "name": "FAM20C:FAM20C substrates", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "H2L2L3", "map_id": "H2L2L3", "name": "anoh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013326", "map_id": "WBGene00013326", "name": "anoh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92172", "map_id": "P92172", "name": "phospho-daf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000903", "map_id": "WBGene00000903", "name": "phospho-daf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16273", "map_id": "O16273", "name": "phospho-tig-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006570", "map_id": "WBGene00006570", "name": "phospho-tig-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEL5", "map_id": "G5EEL5", "name": "phospho-dbl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000936", "map_id": "WBGene00000936", "name": "phospho-dbl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11186", "map_id": "Q11186", "name": "atgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015484", "map_id": "WBGene00015484", "name": "atgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL47", "map_id": "Q9BL47", "name": "phospho-p-TMEM132A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022175", "map_id": "WBGene00022175", "name": "phospho-p-TMEM132A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09EE8", "map_id": "Q09EE8", "name": "phospho-p-STC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044988", "map_id": "WBGene00044988", "name": "phospho-p-STC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC87", "map_id": "G5EC87", "name": "phospho-p-PRKCSH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014249", "map_id": "WBGene00014249", "name": "phospho-p-PRKCSH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34714", "map_id": "P34714", "name": "phospho-ost-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003893", "map_id": "WBGene00003893", "name": "phospho-ost-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17770", "map_id": "Q17770", "name": "pdi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003963", "map_id": "WBGene00003963", "name": "pdi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTW2", "map_id": "Q9XTW2", "name": "famk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010356", "map_id": "WBGene00010356", "name": "famk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11067", "map_id": "Q11067", "name": "phospho-pdi-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015168", "map_id": "WBGene00015168", "name": "phospho-pdi-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQF8", "map_id": "Q8WQF8", "name": "phospho-p-APOL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017220", "map_id": "WBGene00017220", "name": "phospho-p-APOL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU98", "map_id": "Q9XU98", "name": "phospho-eva-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009304", "map_id": "WBGene00009304", "name": "phospho-eva-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBH7", "map_id": "G5EBH7", "name": "phospho-calu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019760", "map_id": "WBGene00019760", "name": "phospho-calu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ51", "map_id": "Q8MQ51", "name": "phospho-nucb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009674", "map_id": "WBGene00009674", "name": "phospho-nucb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBY8", "map_id": "G5EBY8", "name": "phospho-unc-129", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006852", "map_id": "WBGene00006852", "name": "phospho-unc-129", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18096", "map_id": "Q18096", "name": "phospho-p-TNC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007687", "map_id": "WBGene00007687", "name": "phospho-p-TNC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQF7", "map_id": "Q8WQF7", "name": "phospho-p-APOL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22235", "map_id": "Q22235", "name": "phospho-enpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8931885", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10662385", "map_id": "none", "name": "FAM20C:Phosphorylated FAM20C substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_8931884", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10662390", "map_id": "none", "name": "FAM20C:FAM20A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10616363", "map_id": "none", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10616360", "map_id": "none", "name": "mTORC1:RHEB:GTP:AKT1S1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10606983", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-T246-AKT1S1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10612120", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662470", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10606953", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607018", "map_id": "none", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10606964", "map_id": "Q9NAH6", "name": "rsks-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10606968", "map_id": "Q9NAH6", "name": "phospho-rsks-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10606997", "map_id": "none", "name": "mTORC1:p-T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10607016", "map_id": "none", "name": "FKBP1A:sirolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9678687", "map_id": "LigandDisplayForward?ligandId=6031", "name": "sirolimus", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10617104", "map_id": "none", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611523", "map_id": "none", "name": "p-AMPK heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611508", "map_id": "none", "name": "AMPK heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617101", "map_id": "none", "name": "Homologues of PPM1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607031", "map_id": "none", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601072", "map_id": "Q9NEN6", "name": "rps-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607028", "map_id": "Q9NEN6", "name": "phospho-rps-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606878", "map_id": "none", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10606874", "map_id": "none", "name": "RHEB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10606876", "map_id": "none", "name": "RHEB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665764", "map_id": "none", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10646908", "map_id": "none", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10646905", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607048", "map_id": "none", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601231", "map_id": "A0A486WX07", "name": "ifg-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607046", "map_id": "A0A486WX07", "name": "phospho-ifg-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646165", "map_id": "none", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606947", "map_id": "none", "name": "RRAGC,RRAGD:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10606934", "map_id": "none", "name": "RRAGA, RRAGB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10606949", "map_id": "none", "name": "RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646899", "map_id": "none", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10606959", "map_id": "none", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606955", "map_id": "none", "name": "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607041", "map_id": "none", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607036", "map_id": "O01991", "name": "efk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001160", "map_id": "WBGene00001160", "name": "phospho-efk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607039", "map_id": "O01991", "name": "phospho-efk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646167", "map_id": "none", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10606895", "map_id": "none", "name": "mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622209", "map_id": "none", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10617095", "map_id": "none", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10605910", "map_id": "none", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605906", "map_id": "none", "name": "43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TXU7", "map_id": "Q9TXU7", "name": "eif-1.a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019162", "map_id": "WBGene00019162", "name": "eif-1.a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01974", "map_id": "O01974", "name": "eif-3.H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001231", "map_id": "WBGene00001231", "name": "eif-3.H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWI6", "map_id": "Q9XWI6", "name": "eif-3.B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001225", "map_id": "WBGene00001225", "name": "eif-3.B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19706", "map_id": "Q19706", "name": "eif-3.G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001230", "map_id": "WBGene00001230", "name": "eif-3.G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S8", "map_id": "Q965S8", "name": "eif-3.I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001232", "map_id": "WBGene00001232", "name": "eif-3.I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWP7", "map_id": "Q9XWP7", "name": "eif-3.j", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012738", "map_id": "WBGene00012738", "name": "eif-3.j", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34339", "map_id": "P34339", "name": "egl-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001209", "map_id": "WBGene00001209", "name": "egl-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94261", "map_id": "Q94261", "name": "cif-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019543", "map_id": "WBGene00019543", "name": "cif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QW0", "map_id": "Q95QW0", "name": "eif-3.L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015920", "map_id": "WBGene00015920", "name": "eif-3.L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XR0", "map_id": "Q95XR0", "name": "eif-2gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021466", "map_id": "WBGene00021466", "name": "eif-2gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21230", "map_id": "Q21230", "name": "eif-2beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010560", "map_id": "WBGene00010560", "name": "eif-2beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKU3", "map_id": "Q9BKU3", "name": "phospho-eif-2alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021351", "map_id": "WBGene00021351", "name": "phospho-eif-2alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02328", "map_id": "O02328", "name": "eif-3.C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001226", "map_id": "WBGene00001226", "name": "eif-3.C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61820", "map_id": "O61820", "name": "eif-3.E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001228", "map_id": "WBGene00001228", "name": "eif-3.E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30642", "map_id": "P30642", "name": "eif-3.D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001227", "map_id": "WBGene00001227", "name": "eif-3.D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUP3", "map_id": "Q9XUP3", "name": "eif-3.K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001233", "map_id": "WBGene00001233", "name": "eif-3.K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18967", "map_id": "Q18967", "name": "eif-3.F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001229", "map_id": "WBGene00001229", "name": "eif-3.F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605890", "map_id": "Q27389", "name": "phospho-rpl-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605908", "map_id": "none", "name": "phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605914", "map_id": "none", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605912", "map_id": "none", "name": "60s ribosomal complex lacking L13a subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601331", "map_id": "Q27389", "name": "rpl-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10665593", "map_id": "none", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646960", "map_id": "none", "name": "inactive RAFs:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646968", "map_id": "none", "name": "dephosphorylated inactive RAFS:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665590", "map_id": "none", "name": "S-GCC MRAS:GTP:SHOC2:PP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGA7", "map_id": "G5EGA7", "name": "ras-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004311", "map_id": "WBGene00004311", "name": "ras-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22875", "map_id": "Q22875", "name": "soc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004929", "map_id": "WBGene00004929", "name": "soc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48727", "map_id": "P48727", "name": "gsp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001748", "map_id": "WBGene00001748", "name": "gsp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665461", "map_id": "none", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10665346", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10607835", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10635276", "map_id": "none", "name": "AMOT proteins bind WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635239", "map_id": "none", "name": "AMOT proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21036", "map_id": "Q21036", "name": "AMOTL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019102", "map_id": "WBGene00019102", "name": "AMOTL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635274", "map_id": "none", "name": "AMOT:WWTR1 (TAZ)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647126", "map_id": "none", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647122", "map_id": "Q95QN6", "name": "brap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017144", "map_id": "WBGene00017144", "name": "brap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647124", "map_id": "none", "name": "p21 RAS:GTP:BRAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95QN6", "map_id": "Q95QN6", "name": "brap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10640339", "map_id": "none", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_383505", "compartment_display": "extracellular exosome" }, { "id": "species_10640317", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828050", "compartment_display": "multivesicular body, internal vesicle", "complex": "true" }, { "id": "Q7YWX7", "map_id": "Q7YWX7", "name": "mig-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003246", "map_id": "WBGene00003246", "name": "mig-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG05", "map_id": "G5EG05", "name": "egl-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001188", "map_id": "WBGene00001188", "name": "egl-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640337", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_383505", "compartment_display": "extracellular exosome", "complex": "true" }, { "id": "reaction_10658530", "map_id": "none", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658515", "map_id": "none", "name": "Phosphorylated ERBB2:EGFR heterodimers:PTPN18", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658527", "map_id": "none", "name": "Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640341", "map_id": "none", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10639050", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609406", "map_id": "none", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609384", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10617376", "map_id": "none", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10617364", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10617374", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10665529", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10665523", "map_id": "P22981", "name": "phospho-let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10625038", "map_id": "P41958", "name": "ced-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00000423", "map_id": "WBGene00000423", "name": "ced-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665527", "map_id": "none", "name": "p-S181-S-Farn-Me KRAS4B:BCL2L1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "P41958", "map_id": "P41958", "name": "ced-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665450", "map_id": "none", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10665357", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10665341", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10665447", "map_id": "G5EEP3", "name": "fce-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00001406", "map_id": "WBGene00001406", "name": "fce-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646527", "map_id": "none", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646523", "map_id": "none", "name": "SOX4,SOX13,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A1N7SZG1", "map_id": "A0A1N7SZG1", "name": "sox-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015716", "map_id": "WBGene00015716", "name": "sox-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23045", "map_id": "Q23045", "name": "egl-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001182", "map_id": "WBGene00001182", "name": "egl-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20201", "map_id": "Q20201", "name": "sox-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004950", "map_id": "WBGene00004950", "name": "sox-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T3B9", "map_id": "Q8T3B9", "name": "sem-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004771", "map_id": "WBGene00004771", "name": "sem-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21305", "map_id": "Q21305", "name": "sox-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004949", "map_id": "WBGene00004949", "name": "sox-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646525", "map_id": "none", "name": "TCF/LEF:CTNNB1:SOX4,SOX13,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665525", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10665507", "map_id": "P22981", "name": "phospho-let-60", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10647016", "map_id": "none", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647013", "map_id": "none", "name": "RAS GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "W6RS10", "map_id": "W6RS10", "name": "RASGEF1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019902", "map_id": "WBGene00019902", "name": "RASGEF1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C6KRM7", "map_id": "C6KRM7", "name": "rig-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004372", "map_id": "WBGene00004372", "name": "rig-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB9", "map_id": "G5EDB9", "name": "pxf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004254", "map_id": "WBGene00004254", "name": "pxf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611938", "map_id": "none", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611936", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10617354", "map_id": "none", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617336", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10617352", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10635617", "map_id": "none", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635201", "map_id": "O45797", "name": "wts-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007047", "map_id": "WBGene00007047", "name": "phospho-wts-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635613", "map_id": "G5ECP0", "name": "nphp-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011261", "map_id": "WBGene00011261", "name": "nphp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635615", "map_id": "none", "name": "NPHP4:LATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECP0", "map_id": "G5ECP0", "name": "nphp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45797", "map_id": "O45797", "name": "phospho-wts-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642546", "map_id": "none", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642538", "map_id": "none", "name": "HSP27 oligomer:F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A1I6CMC9", "map_id": "A0A1I6CMC9", "name": "phospho-p-S15,S78,S82-HSP27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021943", "map_id": "WBGene00021943", "name": "phospho-p-S15,S78,S82-HSP27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642543", "map_id": "A0A1I6CMC9", "name": "phospho-p-S15,S78,S82-HSP27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10609380", "map_id": "none", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609278", "map_id": "none", "name": "Active PDGF dimers (AA, AB, BB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10609364", "map_id": "none", "name": "PDGFRA, PDGFRB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10609374", "map_id": "none", "name": "PDGF:PDGF receptor dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10609376", "map_id": "none", "name": "PDGFR:type II PDGFR-binding TKIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=5659", "map_id": "LigandDisplayForward?ligandId=5659", "name": "LigandDisplayForward?ligandId=5659", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5678", "map_id": "LigandDisplayForward?ligandId=5678", "name": "LigandDisplayForward?ligandId=5678", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5890", "map_id": "LigandDisplayForward?ligandId=5890", "name": "LigandDisplayForward?ligandId=5890", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9175", "map_id": "LigandDisplayForward?ligandId=9175", "name": "LigandDisplayForward?ligandId=9175", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5687", "map_id": "LigandDisplayForward?ligandId=5687", "name": "LigandDisplayForward?ligandId=5687", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7426", "map_id": "LigandDisplayForward?ligandId=7426", "name": "LigandDisplayForward?ligandId=7426", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5936", "map_id": "LigandDisplayForward?ligandId=5936", "name": "LigandDisplayForward?ligandId=5936", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5891", "map_id": "LigandDisplayForward?ligandId=5891", "name": "LigandDisplayForward?ligandId=5891", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5711", "map_id": "LigandDisplayForward?ligandId=5711", "name": "LigandDisplayForward?ligandId=5711", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5697", "map_id": "LigandDisplayForward?ligandId=5697", "name": "LigandDisplayForward?ligandId=5697", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5713", "map_id": "LigandDisplayForward?ligandId=5713", "name": "LigandDisplayForward?ligandId=5713", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5656", "map_id": "LigandDisplayForward?ligandId=5656", "name": "LigandDisplayForward?ligandId=5656", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609378", "map_id": "none", "name": "PDGFRA:olaratumab", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=9172", "map_id": "LigandDisplayForward?ligandId=9172", "name": "LigandDisplayForward?ligandId=9172", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665504", "map_id": "none", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647018", "map_id": "none", "name": "p21 RAS:GTP:homo/heterodimerized RAF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9657579", "map_id": "none", "name": "RAF dimer inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611822", "map_id": "none", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611819", "map_id": "none", "name": "BMP:p-BMPR:Endofin:SMAD1/5/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "P45896", "map_id": "P45896", "name": "sma-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004857", "map_id": "WBGene00004857", "name": "sma-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09488", "map_id": "Q09488", "name": "sma-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004860", "map_id": "WBGene00004860", "name": "sma-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02330", "map_id": "Q02330", "name": "sma-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004856", "map_id": "WBGene00004856", "name": "sma-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611801", "map_id": "none", "name": "BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10665991", "map_id": "none", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665979", "map_id": "none", "name": "p-Y705,S727-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10643019", "map_id": "none", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10602372", "map_id": "Q9TYW1", "name": "vha-19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00021952", "map_id": "WBGene00021952", "name": "vha-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602367", "map_id": "none", "name": "V-ATPase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10602374", "map_id": "none", "name": "V-ATPase:ATP6AP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9TYW1", "map_id": "Q9TYW1", "name": "vha-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639026", "map_id": "none", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10638950", "map_id": "Q9XW41", "name": "snx-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006503", "map_id": "WBGene00006503", "name": "snx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638940", "map_id": "none", "name": "VPS35:VPS29:VPS26", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21053", "map_id": "Q21053", "name": "vps-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006933", "map_id": "WBGene00006933", "name": "vps-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01258", "map_id": "O01258", "name": "vps-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006931", "map_id": "WBGene00006931", "name": "vps-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86D99", "map_id": "Q86D99", "name": "vps-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014234", "map_id": "WBGene00014234", "name": "vps-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638945", "map_id": "Q7YWX7", "name": "mig-14", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10638952", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q9XW41", "map_id": "Q9XW41", "name": "snx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665465", "map_id": "none", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10665981", "map_id": "none", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665977", "map_id": "none", "name": "Homologues of p-Y705,S727-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661675", "map_id": "none", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10642505", "map_id": "none", "name": "p-VAV family:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10642524", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609414", "map_id": "none", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609280", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10609412", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10634222", "map_id": "none", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10634211", "map_id": "none", "name": "EGF:EGFR:ERBB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10629224", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10634220", "map_id": "none", "name": "ERBB2:TKIs:ERBIN:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7717", "map_id": "LigandDisplayForward?ligandId=7717", "name": "LigandDisplayForward?ligandId=7717", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5667", "map_id": "LigandDisplayForward?ligandId=5667", "name": "LigandDisplayForward?ligandId=5667", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7643", "map_id": "LigandDisplayForward?ligandId=7643", "name": "LigandDisplayForward?ligandId=7643", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7944", "map_id": "LigandDisplayForward?ligandId=7944", "name": "LigandDisplayForward?ligandId=7944", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5675", "map_id": "LigandDisplayForward?ligandId=5675", "name": "LigandDisplayForward?ligandId=5675", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7883", "map_id": "LigandDisplayForward?ligandId=7883", "name": "LigandDisplayForward?ligandId=7883", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=11580", "map_id": "LigandDisplayForward?ligandId=11580", "name": "LigandDisplayForward?ligandId=11580", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5692", "map_id": "LigandDisplayForward?ligandId=5692", "name": "LigandDisplayForward?ligandId=5692", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02108", "map_id": "O02108", "name": "cdc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021097", "map_id": "WBGene00021097", "name": "cdc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5686", "map_id": "LigandDisplayForward?ligandId=5686", "name": "LigandDisplayForward?ligandId=5686", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634216", "map_id": "none", "name": "ERBB2:trastuzumab:ERBIN:HSP90:CDC37", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=5082", "map_id": "LigandDisplayForward?ligandId=5082", "name": "LigandDisplayForward?ligandId=5082", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664063", "map_id": "none", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664058", "map_id": "none", "name": "RHOT1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q94263", "map_id": "Q94263", "name": "miro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019544", "map_id": "WBGene00019544", "name": "miro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664060", "map_id": "none", "name": "RHOT1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10657704", "map_id": "none", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657699", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:GAB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10639068", "map_id": "none", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10639066", "map_id": "none", "name": "WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10639032", "map_id": "Q7YWX7", "name": "mig-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10631286", "map_id": "none", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10631284", "map_id": "none", "name": "PDGF:p-PDGFR dimer:p-PLCgamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640145", "map_id": "none", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640137", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23089", "map_id": "Q23089", "name": "xpo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10640143", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639544", "map_id": "none", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628899", "map_id": "P34545", "name": "cbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10639542", "map_id": "none", "name": "TCF/LEF:CTNNB1:CBP/p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643280", "map_id": "none", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10643276", "map_id": "none", "name": "2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10643278", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665545", "map_id": "none", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665533", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10645503", "map_id": "Q18268", "name": "pdl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003966", "map_id": "WBGene00003966", "name": "pdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665537", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18268", "map_id": "Q18268", "name": "pdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665543", "map_id": "none", "name": "PDE6D:Deltarasin", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "pubchem.compound:73292904", "map_id": "pubchem.compound:73292904", "name": "pubchem.compound:73292904", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641377", "map_id": "none", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612014", "map_id": "none", "name": "Homologues of DVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10641373", "map_id": "Q09291", "name": "hecw-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009738", "map_id": "WBGene00009738", "name": "hecw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10641375", "map_id": "none", "name": "DVL1:HECW1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09291", "map_id": "Q09291", "name": "hecw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635641", "map_id": "none", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635621", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635623", "map_id": "none", "name": "YAP1:TJP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665516", "map_id": "none", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665513", "map_id": "none", "name": "PKCZ,PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYN2", "map_id": "H2KYN2", "name": "pkg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015650", "map_id": "WBGene00015650", "name": "pkg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664691", "map_id": "none", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664678", "map_id": "P41990", "name": "apx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664684", "map_id": "P41990", "name": "phospho-apx-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648862", "map_id": "none", "name": "p-S182 MAPKAPK5 phosphorylates FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648859", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638831", "map_id": "none", "name": "Homologues of p-T182-MAPKAPK5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648164", "map_id": "none", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648138", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648129", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10630128", "map_id": "none", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10630119", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10639653", "map_id": "none", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639649", "map_id": "none", "name": "TLE1:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639647", "map_id": "none", "name": "TCF/LEF:CTNNB1:APC:CTBP:BTRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639318", "map_id": "none", "name": "TCF/LEF:TLE:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639651", "map_id": "none", "name": "APC:CTBP:CTNNB1:BTRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10617040", "map_id": "none", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609408", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617037", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10635629", "map_id": "none", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635627", "map_id": "none", "name": "YAP1:TJP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639540", "map_id": "none", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605206", "map_id": "Q17431", "name": "leo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007110", "map_id": "WBGene00007110", "name": "leo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605196", "map_id": "Q9N5U5", "name": "cdc-73", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00018064", "map_id": "WBGene00018064", "name": "cdc-73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639538", "map_id": "none", "name": "TCF/LEF:CTNNB1:PAF1-like complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17431", "map_id": "Q17431", "name": "leo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5U5", "map_id": "Q9N5U5", "name": "cdc-73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665743", "map_id": "none", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617609", "map_id": "none", "name": "PDGF alpha receptor: PDGF dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9674075", "map_id": "none", "name": "type I PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=10368", "map_id": "LigandDisplayForward?ligandId=10368", "name": "LigandDisplayForward?ligandId=10368", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5698", "map_id": "LigandDisplayForward?ligandId=5698", "name": "LigandDisplayForward?ligandId=5698", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7882", "map_id": "LigandDisplayForward?ligandId=7882", "name": "LigandDisplayForward?ligandId=7882", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617614", "map_id": "none", "name": "PDGFR:type I PDGFR-binding TKIs", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10639070", "map_id": "none", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10639028", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10665520", "map_id": "none", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10617616", "map_id": "none", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617611", "map_id": "none", "name": "Phospho PDGF alpha receptor:PDGF dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665745", "map_id": "none", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9674079", "map_id": "none", "name": "type II PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635241", "map_id": "none", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635225", "map_id": "Q19404", "name": "phospho-yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635227", "map_id": "none", "name": "p-LATS2:p-MOB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20186", "map_id": "Q20186", "name": "phospho-mob-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009551", "map_id": "WBGene00009551", "name": "phospho-mob-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635635", "map_id": "none", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635631", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635633", "map_id": "none", "name": "WWTR1:TJP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659092", "map_id": "none", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659088", "map_id": "P28191", "name": "ptp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622260", "map_id": "none", "name": "Homologues of p-T183,Y185-MAPK12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659090", "map_id": "none", "name": "PTPN3:p-T183,Y185-MAPK12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P28191", "map_id": "P28191", "name": "ptp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630135", "map_id": "none", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10630132", "map_id": "none", "name": "NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10638958", "map_id": "none", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10638956", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10657399", "map_id": "none", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657396", "map_id": "Q19019", "name": "phospho-sli-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10631237", "map_id": "none", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612130", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643283", "map_id": "none", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10642526", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617742", "map_id": "none", "name": "PAK1,2,3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665468", "map_id": "none", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10658628", "map_id": "none", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10617342", "map_id": "none", "name": "proPDGF-AB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10609394", "map_id": "Q9N413", "name": "pvf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10609276", "map_id": "none", "name": "PDGF A/B heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10658622", "map_id": "Q9N413", "name": "pvf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10602377", "map_id": "none", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_74722", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "reaction_10617380", "map_id": "none", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615471", "map_id": "Q95PX0", "name": "nck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10617378", "map_id": "none", "name": "PDGF:Phospho-PDGFR receptor dimer:Nck", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10648160", "map_id": "none", "name": "p-S MAPKAPK5 phosphorylates HSPB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642534", "map_id": "A0A1I6CMC9", "name": "HSPB1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648149", "map_id": "A0A1I6CMC9", "name": "phospho-p-S78,S82 HSPB1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648157", "map_id": "none", "name": "p-S MAPKAPK5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657390", "map_id": "none", "name": "Phosphorylated PXN recruits the CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636369", "map_id": "none", "name": "CRK:DOCK180:ELMO1,ELMO2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8STE5", "map_id": "Q8STE5", "name": "ced-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000426", "map_id": "WBGene00000426", "name": "ced-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657386", "map_id": "Q09476", "name": "phospho-pxl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657388", "map_id": "none", "name": "p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617078", "map_id": "none", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617074", "map_id": "none", "name": "STAT family members", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617076", "map_id": "none", "name": "PDGF:phospho-PDGF receptor dimer:STAT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10642518", "map_id": "none", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10642515", "map_id": "Q18425", "name": "phospho-sphk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10642501", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664080", "map_id": "none", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664076", "map_id": "none", "name": "RHOT2 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91503", "map_id": "P91503", "name": "trak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020838", "map_id": "WBGene00020838", "name": "trak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664078", "map_id": "none", "name": "RHOT2:GTP:RHOT2 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10646973", "map_id": "none", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10647020", "map_id": "none", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646912", "map_id": "Q07292", "name": "phospho-lin-45", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646941", "map_id": "none", "name": "p21 RAS:GTP:'activator' RAF:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665548", "map_id": "none", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665539", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19705", "map_id": "Q19705", "name": "evl-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001358", "map_id": "WBGene00001358", "name": "evl-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642764", "map_id": "none", "name": "ARL2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10609386", "map_id": "none", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602421", "map_id": "none", "name": "PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635677", "map_id": "none", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635266", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635675", "map_id": "none", "name": "p-WWTR1:DVL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10634132", "map_id": "none", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10634127", "map_id": "none", "name": "ERBB2:ERBIN:HSP90:CDC37", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10634129", "map_id": "none", "name": "Ub-ERBB2:ERBIN:Ub-HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10639322", "map_id": "none", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10634230", "map_id": "none", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10634206", "map_id": "none", "name": "EGF:EGFR:p-Y877-ERBB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10647265", "map_id": "none", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647259", "map_id": "none", "name": "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10647263", "map_id": "none", "name": "p21RAS:GTP:p-S621 RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10647209", "map_id": "Q07292", "name": "phospho-lin-45", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10647219", "map_id": "none", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647024", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10647217", "map_id": "Q07292", "name": "phospho-lin-45", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10634202", "map_id": "none", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10634198", "map_id": "none", "name": "Homologues of MATK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XX42", "map_id": "Q9XX42", "name": "MATK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020106", "map_id": "WBGene00020106", "name": "MATK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7I5", "map_id": "Q8I7I5", "name": "rol-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004395", "map_id": "WBGene00004395", "name": "rol-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3ARA3", "map_id": "A0A0K3ARA3", "name": "MATK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10925", "map_id": "Q10925", "name": "sid-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002207", "map_id": "WBGene00002207", "name": "sid-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634200", "map_id": "none", "name": "p-ERBB2 heterodimers:MATK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609417", "map_id": "none", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10645710", "map_id": "none", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10645706", "map_id": "none", "name": "SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10645708", "map_id": "none", "name": "CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643579", "map_id": "none", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643575", "map_id": "O61845", "name": "chd-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007053", "map_id": "WBGene00007053", "name": "chd-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643577", "map_id": "none", "name": "CTNNB1:CHD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O61845", "map_id": "O61845", "name": "chd-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646962", "map_id": "none", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635257", "map_id": "none", "name": "YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646952", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617360", "map_id": "none", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10609272", "map_id": "Q9N413", "name": "pvf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10617356", "map_id": "none", "name": "Extracellular matrix ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:18137", "map_id": "CHEBI:18137", "name": "CHEBI:18137", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17421", "map_id": "CHEBI:17421", "name": "CHEBI:17421", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617358", "map_id": "none", "name": "PDGF A and B chains:ECM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10657409", "map_id": "none", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657402", "map_id": "O45611", "name": "phospho-rga-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657404", "map_id": "none", "name": "p-Y1105-ARHGAP35:RHOA:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635470", "map_id": "none", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635468", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10639738", "map_id": "none", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10639703", "map_id": "none", "name": "MYC gene: H2B K121ub nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639715", "map_id": "none", "name": "MYC gene:H2B K121ub H3K4me3 nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10639735", "map_id": "none", "name": "TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44447", "map_id": "O44447", "name": "PYGO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015330", "map_id": "WBGene00015330", "name": "PYGO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639030", "map_id": "none", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10638954", "map_id": "Q7YWX7", "name": "mig-14", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10639016", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10642512", "map_id": "none", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10642509", "map_id": "none", "name": "PKCA,PKCB,PKCD,PKCZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10642479", "map_id": "none", "name": "p-PKCA,p-PKCB,p-PKCZ,p-PKCD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635253", "map_id": "none", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635210", "map_id": "Q20186", "name": "phospho-mob-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635212", "map_id": "none", "name": "LATS:p-MOB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612216", "map_id": "none", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611811", "map_id": "none", "name": "BMPRI dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611783", "map_id": "none", "name": "BMPRII dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611813", "map_id": "none", "name": "BMPRII:BMPRI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10635251", "map_id": "none", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635248", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10635222", "map_id": "none", "name": "p-LATS:p-MOB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611755", "map_id": "none", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607878", "map_id": "G5EDM7", "name": "daf-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611751", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611753", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4:SKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647134", "map_id": "none", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647131", "map_id": "none", "name": "p21 RAS:GTP:ub-BRAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665384", "map_id": "none", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10665366", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10665381", "map_id": "none", "name": "ZDHHC9:GOLGA7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9XWD7", "map_id": "Q9XWD7", "name": "dhhc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012948", "map_id": "WBGene00012948", "name": "dhhc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647164", "map_id": "none", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10647160", "map_id": "Q9U1V1", "name": "paqr-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00013457", "map_id": "WBGene00013457", "name": "paqr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647162", "map_id": "none", "name": "PAQR3:inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9U1V1", "map_id": "Q9U1V1", "name": "paqr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639023", "map_id": "none", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10639000", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10639021", "map_id": "Q21336", "name": "tmed-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010670", "map_id": "WBGene00010670", "name": "tmed-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635639", "map_id": "none", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635637", "map_id": "none", "name": "WWTR1:TJP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665440", "map_id": "none", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607833", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_8848337", "map_id": "CHEBI:7896", "name": "PALM(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10665433", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVA7", "map_id": "Q9XVA7", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044003", "map_id": "WBGene00044003", "name": "ABHD17B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5FC17", "map_id": "Q5FC17", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL52", "map_id": "Q9BL52", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21221", "map_id": "Q21221", "name": "aho-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00045192", "map_id": "WBGene00045192", "name": "aho-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JKU8", "map_id": "Q7JKU8", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A061ACY0", "map_id": "A0A061ACY0", "name": "ath-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010564", "map_id": "WBGene00010564", "name": "ath-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665435", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9647934", "map_id": "pubchem.compound:45100481", "name": "Palmostatin B", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10639074", "map_id": "none", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10617748", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617746", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609286", "map_id": "none", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609282", "map_id": "Q22070", "name": "plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10609284", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PLC-gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643316", "map_id": "none", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10643309", "map_id": "none", "name": "VE-cadherin-Catenin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90947", "map_id": "P90947", "name": "hmp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001978", "map_id": "WBGene00001978", "name": "hmp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643313", "map_id": "none", "name": "p-S665-VE-cadherin-Catenin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10631289", "map_id": "none", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10617362", "map_id": "none", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617314", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Crk", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665502", "map_id": "none", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9652360", "map_id": "none", "name": "lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10648147", "map_id": "none", "name": "p-T182 MAPKAPK5 phosphorylates FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648136", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648144", "map_id": "none", "name": "Homologues of p-T182 MAPKAPK5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647202", "map_id": "none", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10647083", "map_id": "none", "name": "p-2S MAP2K1:p-2S MAPK2K2 heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10647199", "map_id": "none", "name": "p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611733", "map_id": "none", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611729", "map_id": "none", "name": "p-2S-SMAD1/5/8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611731", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666054", "map_id": "none", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10666039", "map_id": "none", "name": "RHOBTB3:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10666051", "map_id": "none", "name": "RHOBTB3:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10630126", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10630123", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10646970", "map_id": "none", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10648126", "map_id": "none", "name": "PKA phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638817", "map_id": "none", "name": "Homologues of MAPKAPK5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648121", "map_id": "none", "name": "Homologues of p-S115 MAPKAPK5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648123", "map_id": "P21137", "name": "kin-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10665350", "map_id": "none", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10665348", "map_id": "none", "name": "ICMT:Zn2+:Cysmethynil", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "pubchem.compound:6918831", "map_id": "pubchem.compound:6918831", "name": "pubchem.compound:6918831", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665437", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10611834", "map_id": "none", "name": "PI3K synthesizes PIP3 downstream of ALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611831", "map_id": "none", "name": "active ALK:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612132", "map_id": "none", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612122", "map_id": "none", "name": "eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665372", "map_id": "none", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10646948", "map_id": "none", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10646939", "map_id": "none", "name": "'activator' RAF:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10646946", "map_id": "Q9BKU4", "name": "phb-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004014", "map_id": "WBGene00004014", "name": "phb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635472", "map_id": "none", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10629366", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10665568", "map_id": "none", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665566", "map_id": "none", "name": "p21 RAS:GTP:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643318", "map_id": "none", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10664074", "map_id": "none", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10664068", "map_id": "P91503", "name": "trak-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664072", "map_id": "none", "name": "RHOT1:GTP:RHOT1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10659203", "map_id": "none", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659200", "map_id": "none", "name": "p-S459 PTPN3:p-T183,Y185-MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635272", "map_id": "none", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635270", "map_id": "none", "name": "AMOT:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10609396", "map_id": "none", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10609392", "map_id": "none", "name": "proPDGF-AA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10609268", "map_id": "none", "name": "active PDGF-AA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10611815", "map_id": "none", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10666047", "map_id": "none", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10666043", "map_id": "none", "name": "RHOBTB3 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19213", "map_id": "Q19213", "name": "vhl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006922", "map_id": "WBGene00006922", "name": "vhl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666045", "map_id": "none", "name": "RHOBTB3:ATP:RHOBTB3 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10611805", "map_id": "none", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17941", "compartment_display": "early endosome" }, { "id": "species_10611803", "map_id": "none", "name": "BMP:p-BMPR:Endofin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10641382", "map_id": "none", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641379", "map_id": "none", "name": "ub-DVL1:HECW1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10634209", "map_id": "none", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629229", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10648162", "map_id": "none", "name": "p-S115 MAPKAPK5 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648155", "map_id": "none", "name": "Homologues of p-S115 MAPKAPK5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647274", "map_id": "none", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647271", "map_id": "Q9NES8", "name": "pph-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10647211", "map_id": "none", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647022", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10609410", "map_id": "none", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10608501", "map_id": "G5EE56", "name": "src-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10631282", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10631254", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10631279", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617626", "map_id": "none", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617621", "map_id": "none", "name": "PDGF alpha/beta:PDGF AB and BB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617623", "map_id": "none", "name": "Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665463", "map_id": "none", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607827", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10639072", "map_id": "none", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10602395", "map_id": "none", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10602393", "map_id": "none", "name": "insulin receptor", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q968Y9", "map_id": "Q968Y9", "name": "daf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000898", "map_id": "WBGene00000898", "name": "daf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602228", "map_id": "none", "name": "Insulin receptor", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10635619", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10609403", "map_id": "none", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609398", "map_id": "none", "name": "PDGF beta receptor:PDGF chain B homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10609400", "map_id": "none", "name": "Phospho PDGF beta receptor: PDGF chain B homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10634137", "map_id": "none", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10634134", "map_id": "none", "name": "Ub-ERBB2:ERBIN:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627613", "map_id": "Q23639", "name": "cul-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000840", "map_id": "WBGene00000840", "name": "cul-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665363", "map_id": "none", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665353", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10665361", "map_id": "none", "name": "FNTA:FNTB:FTase inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6531", "map_id": "LigandDisplayForward?ligandId=6531", "name": "LigandDisplayForward?ligandId=6531", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8025", "map_id": "LigandDisplayForward?ligandId=8025", "name": "LigandDisplayForward?ligandId=8025", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8024", "map_id": "LigandDisplayForward?ligandId=8024", "name": "LigandDisplayForward?ligandId=8024", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:216453", "map_id": "pubchem.compound:216453", "name": "pubchem.compound:216453", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8028", "map_id": "LigandDisplayForward?ligandId=8028", "name": "LigandDisplayForward?ligandId=8028", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8026", "map_id": "LigandDisplayForward?ligandId=8026", "name": "LigandDisplayForward?ligandId=8026", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8030", "map_id": "LigandDisplayForward?ligandId=8030", "name": "LigandDisplayForward?ligandId=8030", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612224", "map_id": "none", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10612218", "map_id": "G5EDS9", "name": "tag-68", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612222", "map_id": "none", "name": "I-SMAD:p-2S-SMAD1/5/8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10630279", "map_id": "none", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10630276", "map_id": "none", "name": "p-VAV1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10647255", "map_id": "none", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10647073", "map_id": "O16264", "name": "PEBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10635261", "map_id": "none", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635259", "map_id": "none", "name": "p-YAP1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665609", "map_id": "none", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665605", "map_id": "none", "name": "S-Farn-Me-2xPalmS HRAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10665607", "map_id": "none", "name": "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665535", "map_id": "none", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10665386", "map_id": "none", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9653479", "map_id": "none", "name": "FNTB inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664082", "map_id": "none", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10659095", "map_id": "none", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622802", "map_id": "none", "name": "Homologues of MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664688", "map_id": "none", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10614393", "map_id": "P41990", "name": "apx-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10664686", "map_id": "none", "name": "p-4S-NICD4:YWHAZ dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611757", "map_id": "none", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10665541", "map_id": "none", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10657393", "map_id": "none", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10657407", "map_id": "none", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10641386", "map_id": "none", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10642497", "map_id": "none", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642494", "map_id": "none", "name": "p-PKC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635268", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10658626", "map_id": "none", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10617340", "map_id": "none", "name": "proPDGF-BB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10609274", "map_id": "none", "name": "active PDGF-BB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10666049", "map_id": "none", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10666037", "map_id": "none", "name": "Homologues of RHOBTB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10624150", "map_id": "none", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561049", "map_id": "none", "name": "OAT1-3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=1231", "map_id": "LigandDisplayForward?ligandId=1231", "name": "LigandDisplayForward?ligandId=1231", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_561052", "map_id": "CHEBI:2453", "name": "ACV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:104011", "map_id": "CHEBI:104011", "name": "CHEBI:104011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_561075", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_561078", "map_id": "none", "name": "OAT1-3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624147", "map_id": "none", "name": "OAT1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XXQ4", "map_id": "Q9XXQ4", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022348", "map_id": "WBGene00022348", "name": "SLC22A7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGL6", "map_id": "G5EGL6", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U539", "map_id": "Q9U539", "name": "oct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003842", "map_id": "WBGene00003842", "name": "oct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDA7", "map_id": "G5EDA7", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22686", "map_id": "Q22686", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BI47", "map_id": "Q9BI47", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDU0", "map_id": "G5EDU0", "name": "oat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003837", "map_id": "WBGene00003837", "name": "oat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC34", "map_id": "G5EC34", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4S3P8", "map_id": "G4S3P8", "name": "str-176", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006220", "map_id": "WBGene00006220", "name": "str-176", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91993", "map_id": "P91993", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z118", "map_id": "Q7Z118", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10917", "map_id": "Q10917", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKR9", "map_id": "Q9BKR9", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AWD3", "map_id": "A0A0K3AWD3", "name": "SLC22A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621694", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10621687", "map_id": "Q20026", "name": "chtl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10621668", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10621665", "map_id": "none", "name": "Homologues of RHCG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621588", "map_id": "none", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_209789", "map_id": "CHEBI:18357", "name": "NAd", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621585", "map_id": "Q03614", "name": "dat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000934", "map_id": "WBGene00000934", "name": "dat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621101", "map_id": "none", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621098", "map_id": "none", "name": "Homologues of SLC13A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P46556", "map_id": "P46556", "name": "SLC13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007138", "map_id": "WBGene00007138", "name": "SLC13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32739", "map_id": "P32739", "name": "nac-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003518", "map_id": "WBGene00003518", "name": "nac-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21339", "map_id": "Q21339", "name": "nac-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003519", "map_id": "WBGene00003519", "name": "nac-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93655", "map_id": "Q93655", "name": "nac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003517", "map_id": "WBGene00003517", "name": "nac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624015", "map_id": "none", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_164988", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30235", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624012", "map_id": "none", "name": "SLC22A4, 5,15,16", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q23501", "map_id": "Q23501", "name": "oct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003843", "map_id": "WBGene00003843", "name": "oct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A238UKL7", "map_id": "A0A238UKL7", "name": "SLC22A16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019408", "map_id": "WBGene00019408", "name": "SLC22A16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620434", "map_id": "none", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429130", "map_id": "CHEBI:17268", "name": "Ins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_426910", "map_id": "CHEBI:17268", "name": "Ins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620431", "map_id": "Q21455", "name": "hmit-1.3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00010811", "map_id": "WBGene00010811", "name": "hmit-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621605", "map_id": "none", "name": "GAT1-3 mediate Na+/Cl- dependent GABA transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352011", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621602", "map_id": "none", "name": "SLC6A GABA transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KYM8", "map_id": "H2KYM8", "name": "SLC6A12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018980", "map_id": "WBGene00018980", "name": "SLC6A12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBN9", "map_id": "G5EBN9", "name": "snf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004902", "map_id": "WBGene00004902", "name": "snf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01843", "map_id": "O01843", "name": "SLC6A12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF43", "map_id": "G5EF43", "name": "snf-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004910", "map_id": "WBGene00004910", "name": "snf-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623992", "map_id": "none", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549261", "map_id": "CHEBI:4828", "name": "ERGT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_549260", "map_id": "CHEBI:4828", "name": "ERGT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623984", "map_id": "Q9BKR9", "name": "SLC22A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10623990", "map_id": "G5EFQ5", "name": "rnt-1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10616675", "map_id": "none", "name": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616672", "map_id": "Q03614", "name": "dat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10616012", "map_id": "none", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375468", "map_id": "none", "name": "SLC6A14 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16958", "map_id": "CHEBI:16958", "name": "CHEBI:16958", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352002", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:57427", "map_id": "CHEBI:57427", "name": "CHEBI:57427", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29702", "map_id": "CHEBI:57762", "name": "L-Val", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_375459", "map_id": "none", "name": "SLC6A14 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_73590", "map_id": "CHEBI:57966", "name": "b-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616009", "map_id": "Q9XUG5", "name": "snf-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004908", "map_id": "WBGene00004908", "name": "snf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624152", "map_id": "none", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549266", "map_id": "none", "name": "OCT2 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_549282", "map_id": "CHEBI:16797", "name": "MNA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:31941", "map_id": "CHEBI:31941", "name": "CHEBI:31941", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:65133", "map_id": "CHEBI:65133", "name": "CHEBI:65133", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6798162", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_549237", "map_id": "none", "name": "OCT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10615808", "map_id": "none", "name": "SLC22A1,SLC22A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621636", "map_id": "none", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_444154", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_444152", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "true" }, { "id": "species_10621633", "map_id": "Q9GNP0", "name": "cat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10621682", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621679", "map_id": "Q22947", "name": "rhr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10624222", "map_id": "none", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10624219", "map_id": "none", "name": "Homologues of SLC22A12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621616", "map_id": "none", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352033", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_113538", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10611405", "map_id": "none", "name": "Homologues of SLC6A7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90890", "map_id": "P90890", "name": "snf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004901", "map_id": "WBGene00004901", "name": "snf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUG5", "map_id": "Q9XUG5", "name": "snf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45915", "map_id": "O45915", "name": "snf-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004909", "map_id": "WBGene00004909", "name": "snf-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBM5", "map_id": "G5EBM5", "name": "snf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004904", "map_id": "WBGene00004904", "name": "snf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE39", "map_id": "G5EE39", "name": "snf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004906", "map_id": "WBGene00004906", "name": "snf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621045", "map_id": "none", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433120", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_176483", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621042", "map_id": "Q33BL1", "name": "SLC10A6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10624050", "map_id": "none", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549250", "map_id": "none", "name": "OCT1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_141324", "map_id": "CHEBI:16610", "name": "SPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "CHEBI:15854", "map_id": "CHEBI:15854", "name": "CHEBI:15854", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549264", "map_id": "none", "name": "OCT1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10623954", "map_id": "none", "name": "OCT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621088", "map_id": "none", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433138", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10621085", "map_id": "Q93655", "name": "nac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615145", "map_id": "none", "name": "SLC6A6-mediated uptake of taurine and beta-alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352024", "map_id": "none", "name": "ligands of SLC6A6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352019", "map_id": "none", "name": "ligands of SLC6A6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10615142", "map_id": "none", "name": "Homologues of SLC6A6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624048", "map_id": "none", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549326", "map_id": "none", "name": "OCT3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:46631", "map_id": "CHEBI:46631", "name": "CHEBI:46631", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47499", "map_id": "CHEBI:47499", "name": "CHEBI:47499", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47781", "map_id": "CHEBI:47781", "name": "CHEBI:47781", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_549255", "map_id": "none", "name": "OCT3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10624045", "map_id": "none", "name": "Homologues of SLC22A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621083", "map_id": "none", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433123", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29434", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621080", "map_id": "none", "name": "Homologues of SLC13A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10623957", "map_id": "none", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10622172", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10621070", "map_id": "none", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621067", "map_id": "none", "name": "Homologues of SLC13A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624187", "map_id": "none", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561071", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_561062", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624184", "map_id": "none", "name": "OAT2/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615148", "map_id": "none", "name": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352007", "map_id": "none", "name": "ligands of SLC6A12 (BGT-1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:48950", "map_id": "CHEBI:48950", "name": "CHEBI:48950", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_351982", "map_id": "none", "name": "ligands of SLC6A12 (BGT-1)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611378", "map_id": "none", "name": "Homologues of SLC6A12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10623996", "map_id": "none", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10621631", "map_id": "none", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266029", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10621628", "map_id": "none", "name": "Homologues of SLC6A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624189", "map_id": "none", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10621119", "map_id": "none", "name": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433683", "map_id": "none", "name": "MCT substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:37054", "map_id": "CHEBI:37054", "name": "CHEBI:37054", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9749790", "map_id": "CHEBI:30762", "name": "ST (hepatocyte)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749785", "map_id": "CHEBI:13719", "name": "ASA- (GI cell)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_433686", "map_id": "none", "name": "MCT substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621116", "map_id": "none", "name": "SLC16A8:BSG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624243", "map_id": "none", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_597604", "map_id": "none", "name": "SLC22A18 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=2342", "map_id": "LigandDisplayForward?ligandId=2342", "name": "LigandDisplayForward?ligandId=2342", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5535", "map_id": "LigandDisplayForward?ligandId=5535", "name": "LigandDisplayForward?ligandId=5535", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_597623", "map_id": "none", "name": "SLC22A18 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624240", "map_id": "Q18797", "name": "SLC22A18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008273", "map_id": "WBGene00008273", "name": "SLC22A18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615811", "map_id": "none", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10622170", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10620466", "map_id": "none", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620463", "map_id": "O02228", "name": "cho-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000501", "map_id": "WBGene00000501", "name": "cho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621677", "map_id": "none", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10665294", "map_id": "none", "name": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665291", "map_id": "none", "name": "SLC16A1:BSG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621114", "map_id": "none", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433111", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_1650769", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_433124", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621111", "map_id": "none", "name": "Homologues of SLC13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612194", "map_id": "none", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612187", "map_id": "Q22070", "name": "phospho-plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612192", "map_id": "none", "name": "Activated PLC gamma1 bound to PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612202", "map_id": "none", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612199", "map_id": "Q22070", "name": "phospho-plc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10625850", "map_id": "none", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_917810", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10625847", "map_id": "Q8T666", "name": "cup-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00000846", "map_id": "WBGene00000846", "name": "cup-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625825", "map_id": "none", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10598971", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70784", "map_id": "CHEBI:43074", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598968", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45106", "map_id": "O45106", "name": "ech-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001154", "map_id": "WBGene00001154", "name": "ech-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599029", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599026", "map_id": "Q19278", "name": "hach-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00017301", "map_id": "WBGene00017301", "name": "hach-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598935", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508190", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_508181", "map_id": "none", "name": "KIC, KMVA, KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:28654", "map_id": "CHEBI:28654", "name": "CHEBI:28654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16530", "map_id": "CHEBI:16530", "name": "CHEBI:16530", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17865", "map_id": "CHEBI:17865", "name": "CHEBI:17865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598932", "map_id": "none", "name": "BCAT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P54688", "map_id": "P54688", "name": "bcat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001149", "map_id": "WBGene00001149", "name": "bcat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXD8", "map_id": "Q9XXD8", "name": "PXLP-BCAT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012855", "map_id": "WBGene00012855", "name": "PXLP-BCAT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599039", "map_id": "none", "name": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30004", "map_id": "CHEBI:57700", "name": "2M3OPROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599036", "map_id": "none", "name": "HIBADH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XTI0", "map_id": "Q9XTI0", "name": "HIBADH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007122", "map_id": "WBGene00007122", "name": "HIBADH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623795", "map_id": "none", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70744", "map_id": "CHEBI:15486", "name": "bMC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598958", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34385", "map_id": "P34385", "name": "MCCC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00303021", "map_id": "WBGene00303021", "name": "MCCC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45430", "map_id": "O45430", "name": "mccc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009319", "map_id": "WBGene00009319", "name": "mccc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623787", "map_id": "none", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_508187", "map_id": "none", "name": "KIC,KMVA,KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_508182", "map_id": "none", "name": "Leu, Ile, Val", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10598916", "map_id": "none", "name": "BCAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598991", "map_id": "none", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70829", "map_id": "CHEBI:15449", "name": "aMbHBUT-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598988", "map_id": "none", "name": "HSD17B10 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q19102", "map_id": "Q19102", "name": "ard-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000181", "map_id": "WBGene00000181", "name": "ard-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599011", "map_id": "none", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70851", "map_id": "CHEBI:15479", "name": "ISB-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70858", "map_id": "CHEBI:27754", "name": "MACR-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599008", "map_id": "none", "name": "ACAD8 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95YB2", "map_id": "Q95YB2", "name": "acdh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017874", "map_id": "WBGene00017874", "name": "acdh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599001", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598998", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22100", "map_id": "Q22100", "name": "kat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002183", "map_id": "WBGene00002183", "name": "kat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599021", "map_id": "none", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10598945", "map_id": "none", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70715", "map_id": "CHEBI:15487", "name": "ISV-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10598942", "map_id": "none", "name": "IVD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5EEH6", "map_id": "G5EEH6", "name": "ivd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015326", "map_id": "WBGene00015326", "name": "ivd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598908", "map_id": "none", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508261", "map_id": "none", "name": "BCAA-CoAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598905", "map_id": "none", "name": "lipo-BCKDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q93619", "map_id": "Q93619", "name": "bckd-1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006518", "map_id": "WBGene00006518", "name": "bckd-1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45924", "map_id": "O45924", "name": "bckd-1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012713", "map_id": "WBGene00012713", "name": "bckd-1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598981", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598978", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O44549", "map_id": "O44549", "name": "acdh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019433", "map_id": "WBGene00019433", "name": "acdh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599047", "map_id": "none", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599044", "map_id": "P52713", "name": "alh-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000114", "map_id": "WBGene00000114", "name": "alh-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648280", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648277", "map_id": "none", "name": "ATXN3,ATXN3L,JOSD1,JOSD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IAA2", "map_id": "Q8IAA2", "name": "josd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022190", "map_id": "WBGene00022190", "name": "josd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17850", "map_id": "O17850", "name": "atx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006446", "map_id": "WBGene00006446", "name": "atx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648264", "map_id": "none", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648253", "map_id": "Q23451", "name": "rad-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013924", "map_id": "WBGene00013924", "name": "rad-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648260", "map_id": "O17850", "name": "atx-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648262", "map_id": "none", "name": "ATXN3:RAD23", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23451", "map_id": "Q23451", "name": "rad-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649878", "map_id": "none", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649863", "map_id": "none", "name": "USP21:PolyUb-GATA3,PolyUb-IL33", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8WT44", "map_id": "Q8WT44", "name": "cyk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000874", "map_id": "WBGene00000874", "name": "cyk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649875", "map_id": "none", "name": "USP21:GATA3,IL33", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648387", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649549", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649544", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "D9N129", "map_id": "D9N129", "name": "wdr-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007428", "map_id": "WBGene00007428", "name": "wdr-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34547", "map_id": "P34547", "name": "usp-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011216", "map_id": "WBGene00011216", "name": "usp-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20059", "map_id": "Q20059", "name": "wdr-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009441", "map_id": "WBGene00009441", "name": "wdr-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649546", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649902", "map_id": "none", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649898", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P46504", "map_id": "P46504", "name": "OTUB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017754", "map_id": "WBGene00017754", "name": "OTUB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVR6", "map_id": "Q9XVR6", "name": "otub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007718", "map_id": "WBGene00007718", "name": "otub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649900", "map_id": "none", "name": "OTUB1,(OTUB2):UBE2D1,ESR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10659851", "map_id": "none", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659849", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646598", "map_id": "none", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646587", "map_id": "Q09444", "name": "ubh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006724", "map_id": "WBGene00006724", "name": "ubh-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646594", "map_id": "none", "name": "ADRM1:26S proteasome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09289", "map_id": "Q09289", "name": "rpn-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016981", "map_id": "WBGene00016981", "name": "rpn-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646596", "map_id": "none", "name": "ADRM1:26S proteasome:UCHL5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09444", "map_id": "Q09444", "name": "ubh-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648301", "map_id": "none", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648297", "map_id": "Q17361", "name": "usp-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006856", "map_id": "WBGene00006856", "name": "usp-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648299", "map_id": "none", "name": "ADRM1:26S proteasome:USP14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17361", "map_id": "Q17361", "name": "usp-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648390", "map_id": "none", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648346", "map_id": "none", "name": "USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O16850", "map_id": "O16850", "name": "daf-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648352", "map_id": "none", "name": "USP7:TP53,MDM2,MDM4,FOXO4,PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649596", "map_id": "none", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649591", "map_id": "none", "name": "USP44:PolyUb-CDC20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9GRV2", "map_id": "Q9GRV2", "name": "usp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013506", "map_id": "WBGene00013506", "name": "usp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649593", "map_id": "none", "name": "USP44:CDC20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658620", "map_id": "none", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648512", "map_id": "P0CG71", "name": "ubq-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10658617", "map_id": "Q9N4T5", "name": "otub-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021733", "map_id": "WBGene00021733", "name": "otub-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648492", "map_id": "none", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648487", "map_id": "none", "name": "USP16,USP21:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648489", "map_id": "none", "name": "USP16,USP22:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648531", "map_id": "none", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648504", "map_id": "none", "name": "USP21:PolyUb-RIPK1, PolyUb-DDX58", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648506", "map_id": "none", "name": "USP21:RIPK1,DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648528", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10649660", "map_id": "none", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649653", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17607", "map_id": "O17607", "name": "ruvb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007784", "map_id": "WBGene00007784", "name": "ruvb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649657", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:CCNA1,CCNA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649710", "map_id": "none", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10649706", "map_id": "Q19132", "name": "USP19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008547", "map_id": "WBGene00008547", "name": "USP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628847", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001851", "map_id": "WBGene00001851", "name": "hif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649708", "map_id": "none", "name": "USP19:HIF1A,BIRC2,BIRC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGD2", "map_id": "G5EGD2", "name": "hif-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19132", "map_id": "Q19132", "name": "USP19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648284", "map_id": "none", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646315", "map_id": "none", "name": "VCP hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648282", "map_id": "none", "name": "ATXN3:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648649", "map_id": "none", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648645", "map_id": "none", "name": "RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76671", "map_id": "O76671", "name": "RNF130", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019185", "map_id": "WBGene00019185", "name": "RNF130", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648641", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648647", "map_id": "none", "name": "OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646629", "map_id": "none", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646592", "map_id": "Q09289", "name": "rpn-13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648625", "map_id": "none", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648616", "map_id": "none", "name": "UCHL3,SENP8:NEDD8(1-88)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93725", "map_id": "Q93725", "name": "ned-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003587", "map_id": "WBGene00003587", "name": "ned-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86FN3", "map_id": "Q86FN3", "name": "ulp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006738", "map_id": "WBGene00006738", "name": "ulp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648620", "map_id": "none", "name": "UCHL3,SENP8:NEDD8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648622", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10649635", "map_id": "none", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649630", "map_id": "none", "name": "USP49:Ub-histone H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649632", "map_id": "none", "name": "USP49:Histone H2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649701", "map_id": "none", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10649694", "map_id": "none", "name": "USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01467", "map_id": "O01467", "name": "USP15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019259", "map_id": "WBGene00019259", "name": "USP15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CJY2", "map_id": "V6CJY2", "name": "USP15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649698", "map_id": "none", "name": "USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10648584", "map_id": "none", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648579", "map_id": "none", "name": "UCHL1,UCHL3:Ub-Lys", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965V9", "map_id": "Q965V9", "name": "ubh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006723", "map_id": "WBGene00006723", "name": "ubh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MNY0", "map_id": "Q8MNY0", "name": "ubh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006722", "map_id": "WBGene00006722", "name": "ubh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1131871", "map_id": "CHEBI:32551", "name": "L-lysine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10648581", "map_id": "none", "name": "UCHL1,UCHL3:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656887", "map_id": "none", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10656855", "map_id": "Q8I7G0", "name": "SYS1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "WBGene00020193", "map_id": "WBGene00020193", "name": "SYS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656885", "map_id": "none", "name": "AcM-ARFRP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N3C8", "map_id": "Q9N3C8", "name": "AcM-ARFRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021841", "map_id": "WBGene00021841", "name": "AcM-ARFRP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656865", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q8I7G0", "map_id": "Q8I7G0", "name": "SYS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657132", "map_id": "none", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10657128", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9TY08", "map_id": "Q9TY08", "name": "syx-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022534", "map_id": "WBGene00022534", "name": "syx-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18230", "map_id": "O18230", "name": "vti-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013302", "map_id": "WBGene00013302", "name": "vti-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657130", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10656916", "map_id": "none", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656912", "map_id": "P34445", "name": "ARFIP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010040", "map_id": "WBGene00010040", "name": "ARFIP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656873", "map_id": "none", "name": "MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20758", "map_id": "Q20758", "name": "arl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000187", "map_id": "WBGene00000187", "name": "arl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656914", "map_id": "none", "name": "ARFIP2:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34445", "map_id": "P34445", "name": "ARFIP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656741", "map_id": "none", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10656732", "map_id": "none", "name": "RAB6:GDP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q7YWW8", "map_id": "Q7YWW8", "name": "RGP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010815", "map_id": "WBGene00010815", "name": "RGP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09417", "map_id": "Q09417", "name": "RIC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011071", "map_id": "WBGene00011071", "name": "RIC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656738", "map_id": "none", "name": "RAB6:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10656881", "map_id": "none", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10656879", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10656734", "map_id": "none", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10656722", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10656710", "map_id": "none", "name": "RAB6:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656925", "map_id": "none", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656921", "map_id": "A7LPF8", "name": "unc-69", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006802", "map_id": "WBGene00006802", "name": "unc-69", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656923", "map_id": "none", "name": "SCOC:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A7LPF8", "map_id": "A7LPF8", "name": "unc-69", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656907", "map_id": "none", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10656903", "map_id": "none", "name": "TGN Golgin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A3P6PCP8", "map_id": "A0A3P6PCP8", "name": "golg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010306", "map_id": "WBGene00010306", "name": "golg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18013", "map_id": "Q18013", "name": "gcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002220", "map_id": "WBGene00002220", "name": "gcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656905", "map_id": "none", "name": "AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10651166", "map_id": "none", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10651163", "map_id": "none", "name": "Shortened telomere:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44199", "map_id": "O44199", "name": "rad-50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004296", "map_id": "WBGene00004296", "name": "rad-50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647489", "map_id": "none", "name": "Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647505", "map_id": "none", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647500", "map_id": "none", "name": "DNA DSBs:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10647502", "map_id": "none", "name": "DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647494", "map_id": "none", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647491", "map_id": "none", "name": "Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648887", "map_id": "none", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648884", "map_id": "none", "name": "DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603971", "map_id": "none", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77324", "map_id": "CHEBI:28706", "name": "trans-Hex-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77322", "map_id": "CHEBI:28276", "name": "(S)-Hydroxyhexanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603969", "map_id": "none", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77320", "map_id": "CHEBI:27648", "name": "3-Oxohexanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603967", "map_id": "none", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77318", "map_id": "CHEBI:15517", "name": "BT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10649824", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649819", "map_id": "none", "name": "TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q18963", "map_id": "Q18963", "name": "csa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008403", "map_id": "WBGene00008403", "name": "csa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23088", "map_id": "Q23088", "name": "uvs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022812", "map_id": "WBGene00022812", "name": "uvs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86D18", "map_id": "Q86D18", "name": "Ub-ERCC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010011", "map_id": "WBGene00010011", "name": "Ub-ERCC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22139", "map_id": "Q22139", "name": "sel-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011411", "map_id": "WBGene00011411", "name": "sel-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649821", "map_id": "none", "name": "TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649832", "map_id": "none", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649830", "map_id": "none", "name": "TC-NER post-incision complex:dsDNA with transcription bubble", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648549", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614353", "map_id": "none", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614344", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10614350", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614340", "map_id": "none", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614318", "map_id": "none", "name": "PRC2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10614337", "map_id": "none", "name": "PRC2:Chromatin (H3K27me3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614320", "map_id": "none", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10660998", "map_id": "none", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658635", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10660996", "map_id": "none", "name": "RUNX1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658639", "map_id": "none", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658633", "map_id": "Q95ZL9", "name": "bro-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10666150", "map_id": "none", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617216", "map_id": "none", "name": "IP3-gated Ca-channel type 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10617224", "map_id": "none", "name": "IP3-gated Ca-channel type 3 (open)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10637461", "map_id": "none", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10637458", "map_id": "none", "name": "SCNN channels", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19777", "map_id": "Q19777", "name": "degt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009109", "map_id": "WBGene00009109", "name": "degt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2672379", "map_id": "LigandDisplayForward?ligandId=2421", "name": "amiloride", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10666201", "map_id": "none", "name": "Bitter compound binds bitter taste receptor (TAS2R)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10666195", "map_id": "none", "name": "TAS2R:GNAT3:GDP:GNB1,3:GNG13", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9728981", "map_id": "none", "name": "Ligand of TAS2R (non-orphan)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:73236", "map_id": "CHEBI:73236", "name": "CHEBI:73236", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:10093", "map_id": "CHEBI:10093", "name": "CHEBI:10093", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:9162", "map_id": "CHEBI:9162", "name": "CHEBI:9162", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:351346", "map_id": "CHEBI:351346", "name": "CHEBI:351346", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:7789", "map_id": "CHEBI:7789", "name": "CHEBI:7789", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3768", "map_id": "CHEBI:3768", "name": "CHEBI:3768", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73226", "map_id": "CHEBI:73226", "name": "CHEBI:73226", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:5547", "map_id": "CHEBI:5547", "name": "CHEBI:5547", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73235", "map_id": "CHEBI:73235", "name": "CHEBI:73235", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7074", "map_id": "LigandDisplayForward?ligandId=7074", "name": "LigandDisplayForward?ligandId=7074", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2948", "map_id": "CHEBI:2948", "name": "CHEBI:2948", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2366", "map_id": "CHEBI:2366", "name": "CHEBI:2366", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73222", "map_id": "CHEBI:73222", "name": "CHEBI:73222", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:44975", "map_id": "CHEBI:44975", "name": "CHEBI:44975", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:23736", "map_id": "CHEBI:23736", "name": "CHEBI:23736", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3941", "map_id": "CHEBI:3941", "name": "CHEBI:3941", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:14217", "map_id": "pubchem.compound:14217", "name": "pubchem.compound:14217", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8206", "map_id": "CHEBI:8206", "name": "CHEBI:8206", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138412", "map_id": "CHEBI:138412", "name": "CHEBI:138412", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=86", "map_id": "LigandDisplayForward?ligandId=86", "name": "LigandDisplayForward?ligandId=86", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27641", "map_id": "CHEBI:27641", "name": "CHEBI:27641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:3032338", "map_id": "pubchem.compound:3032338", "name": "pubchem.compound:3032338", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:19518", "map_id": "pubchem.compound:19518", "name": "pubchem.compound:19518", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:4325", "map_id": "CHEBI:4325", "name": "CHEBI:4325", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:69794", "map_id": "pubchem.compound:69794", "name": "pubchem.compound:69794", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:32111", "map_id": "CHEBI:32111", "name": "CHEBI:32111", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3419", "map_id": "CHEBI:3419", "name": "CHEBI:3419", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34750", "map_id": "CHEBI:34750", "name": "CHEBI:34750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36773", "map_id": "CHEBI:36773", "name": "CHEBI:36773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73237", "map_id": "CHEBI:73237", "name": "CHEBI:73237", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73224", "map_id": "CHEBI:73224", "name": "CHEBI:73224", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27613", "map_id": "CHEBI:27613", "name": "CHEBI:27613", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2825", "map_id": "CHEBI:2825", "name": "CHEBI:2825", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:82431", "map_id": "CHEBI:82431", "name": "CHEBI:82431", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:2723704", "map_id": "pubchem.compound:2723704", "name": "pubchem.compound:2723704", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42638", "map_id": "CHEBI:42638", "name": "CHEBI:42638", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17814", "map_id": "CHEBI:17814", "name": "CHEBI:17814", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:69441", "map_id": "CHEBI:69441", "name": "CHEBI:69441", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2853", "map_id": "CHEBI:2853", "name": "CHEBI:2853", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:82346", "map_id": "CHEBI:82346", "name": "CHEBI:82346", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28179", "map_id": "CHEBI:28179", "name": "CHEBI:28179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=1224", "map_id": "LigandDisplayForward?ligandId=1224", "name": "LigandDisplayForward?ligandId=1224", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6976", "map_id": "LigandDisplayForward?ligandId=6976", "name": "LigandDisplayForward?ligandId=6976", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:26948", "map_id": "CHEBI:26948", "name": "CHEBI:26948", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:83501", "map_id": "CHEBI:83501", "name": "CHEBI:83501", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59039", "map_id": "CHEBI:59039", "name": "CHEBI:59039", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46261", "map_id": "CHEBI:46261", "name": "CHEBI:46261", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3445", "map_id": "CHEBI:3445", "name": "CHEBI:3445", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3944", "map_id": "CHEBI:3944", "name": "CHEBI:3944", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28973", "map_id": "CHEBI:28973", "name": "CHEBI:28973", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16150", "map_id": "CHEBI:16150", "name": "CHEBI:16150", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73232", "map_id": "CHEBI:73232", "name": "CHEBI:73232", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18305", "map_id": "CHEBI:18305", "name": "CHEBI:18305", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28579", "map_id": "CHEBI:28579", "name": "CHEBI:28579", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3614", "map_id": "CHEBI:3614", "name": "CHEBI:3614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8502", "map_id": "CHEBI:8502", "name": "CHEBI:8502", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17698", "map_id": "CHEBI:17698", "name": "CHEBI:17698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:71648", "map_id": "pubchem.compound:71648", "name": "pubchem.compound:71648", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:69236", "map_id": "CHEBI:69236", "name": "CHEBI:69236", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2622", "map_id": "CHEBI:2622", "name": "CHEBI:2622", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8692", "map_id": "CHEBI:8692", "name": "CHEBI:8692", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:4638", "map_id": "CHEBI:4638", "name": "CHEBI:4638", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73239", "map_id": "CHEBI:73239", "name": "CHEBI:73239", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:23359", "map_id": "CHEBI:23359", "name": "CHEBI:23359", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28241", "map_id": "CHEBI:28241", "name": "CHEBI:28241", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:48923", "map_id": "CHEBI:48923", "name": "CHEBI:48923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73228", "map_id": "CHEBI:73228", "name": "CHEBI:73228", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17682", "map_id": "CHEBI:17682", "name": "CHEBI:17682", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16226", "map_id": "CHEBI:16226", "name": "CHEBI:16226", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:65408", "map_id": "CHEBI:65408", "name": "CHEBI:65408", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:7939", "map_id": "CHEBI:7939", "name": "CHEBI:7939", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3193", "map_id": "CHEBI:3193", "name": "CHEBI:3193", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:2723593", "map_id": "pubchem.compound:2723593", "name": "pubchem.compound:2723593", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_217315", "map_id": "CHEBI:50673", "name": "MTZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "CHEBI:27732", "map_id": "CHEBI:27732", "name": "CHEBI:27732", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73231", "map_id": "CHEBI:73231", "name": "CHEBI:73231", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16962", "map_id": "CHEBI:16962", "name": "CHEBI:16962", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666199", "map_id": "none", "name": "TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666153", "map_id": "none", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619483", "map_id": "none", "name": "SLC8A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KYP2", "map_id": "H2KYP2", "name": "ncx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003567", "map_id": "WBGene00003567", "name": "ncx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF08", "map_id": "G5EF08", "name": "ncx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003566", "map_id": "WBGene00003566", "name": "ncx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599651", "map_id": "none", "name": "Homologues of CALM1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618036", "map_id": "none", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618031", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618033", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614196", "map_id": "none", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10614200", "map_id": "none", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614198", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636661", "map_id": "none", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357697", "map_id": "CHEBI:16633", "name": "Sec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5359016", "map_id": "none", "name": "reduced acceptor", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5359011", "map_id": "none", "name": "acceptor", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636658", "map_id": "none", "name": "PXLP-K259-SCLY dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19434", "map_id": "Q19434", "name": "PXLP-K259-SCLY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017442", "map_id": "WBGene00017442", "name": "PXLP-K259-SCLY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631233", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10631230", "map_id": "none", "name": "CHK/ETNK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22820", "map_id": "Q22820", "name": "ckc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000515", "map_id": "WBGene00000515", "name": "ckc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46560", "map_id": "P46560", "name": "ckb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000513", "map_id": "WBGene00000513", "name": "ckb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46558", "map_id": "P46558", "name": "ckb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000511", "map_id": "WBGene00000511", "name": "ckb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17610", "map_id": "O17610", "name": "cka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000509", "map_id": "WBGene00000509", "name": "cka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46559", "map_id": "P46559", "name": "ckb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000512", "map_id": "WBGene00000512", "name": "ckb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22942", "map_id": "Q22942", "name": "cka-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000510", "map_id": "WBGene00000510", "name": "cka-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZF3", "map_id": "Q9GZF3", "name": "ckb-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000514", "map_id": "WBGene00000514", "name": "ckb-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631053", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10631050", "map_id": "none", "name": "CEPT1/EPT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EC09", "map_id": "G5EC09", "name": "cept-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009057", "map_id": "WBGene00009057", "name": "cept-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44732", "map_id": "O44732", "name": "ept-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018797", "map_id": "WBGene00018797", "name": "ept-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC25", "map_id": "G5EC25", "name": "cept-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013024", "map_id": "WBGene00013024", "name": "cept-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631200", "map_id": "none", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_110614", "map_id": "CHEBI:37563", "name": "CTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10631197", "map_id": "none", "name": "PCYT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "X5LPX5", "map_id": "X5LPX5", "name": "pcyt-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021352", "map_id": "WBGene00021352", "name": "pcyt-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649500", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696414", "map_id": "CHEBI:17553", "name": "PETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649497", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10631211", "map_id": "none", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10631208", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XXT5", "map_id": "Q9XXT5", "name": "lpin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649269", "map_id": "none", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612768", "map_id": "none", "name": "glycosylated LMAN cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10612734", "map_id": "none", "name": "LMAN family receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q22170", "map_id": "Q22170", "name": "ile-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002071", "map_id": "WBGene00002071", "name": "ile-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612770", "map_id": "none", "name": "LMAN receptor:glycosylated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10649279", "map_id": "none", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612677", "map_id": "Q22361", "name": "cni-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00011648", "map_id": "WBGene00011648", "name": "cni-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612714", "map_id": "none", "name": "Homologues of GRIA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10612716", "map_id": "none", "name": "CNIH2,3:GRIA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q22361", "map_id": "Q22361", "name": "cni-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657200", "map_id": "none", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10657195", "map_id": "none", "name": "RAB1:GTP:TBC1D20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q9XWI2", "map_id": "Q9XWI2", "name": "tbc-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013196", "map_id": "WBGene00013196", "name": "tbc-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657193", "map_id": "Q9XWI2", "name": "tbc-20", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10649271", "map_id": "none", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10612881", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane", "complex": "true" }, { "id": "Q19371", "map_id": "Q19371", "name": "sec-24.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004755", "map_id": "WBGene00004755", "name": "sec-24.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2Z1", "map_id": "Q9U2Z1", "name": "sec-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004754", "map_id": "WBGene00004754", "name": "sec-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23368", "map_id": "Q23368", "name": "sec-24.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004756", "map_id": "WBGene00004756", "name": "sec-24.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFY6", "map_id": "G5EFY6", "name": "sec-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011338", "map_id": "WBGene00011338", "name": "sec-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649147", "map_id": "none", "name": "TRAPPCII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20100", "map_id": "Q20100", "name": "trpp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018088", "map_id": "WBGene00018088", "name": "trpp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4SNB8", "map_id": "G4SNB8", "name": "TRAPPC2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044604", "map_id": "WBGene00044604", "name": "TRAPPC2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93330", "map_id": "Q93330", "name": "trpp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007956", "map_id": "WBGene00007956", "name": "trpp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU81", "map_id": "Q9XU81", "name": "trpp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010699", "map_id": "WBGene00010699", "name": "trpp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1V899", "map_id": "B1V899", "name": "trpp-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022138", "map_id": "WBGene00022138", "name": "trpp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA81", "map_id": "Q9NA81", "name": "trpp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013259", "map_id": "WBGene00013259", "name": "trpp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34605", "map_id": "P34605", "name": "trpp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014222", "map_id": "WBGene00014222", "name": "trpp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02173", "map_id": "O02173", "name": "sedl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021046", "map_id": "WBGene00021046", "name": "sedl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649149", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10649264", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10649260", "map_id": "none", "name": "cis-SNARE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "O62387", "map_id": "O62387", "name": "syx-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012150", "map_id": "WBGene00012150", "name": "syx-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649262", "map_id": "none", "name": "cis-SNARE:NSF hexamer:3xSNAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10612886", "map_id": "none", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10612785", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9U1W1", "map_id": "Q9U1W1", "name": "tfg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006565", "map_id": "WBGene00006565", "name": "tfg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZQ8", "map_id": "H2KZQ8", "name": "sec-16a.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017419", "map_id": "WBGene00017419", "name": "sec-16a.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23445", "map_id": "Q23445", "name": "sar-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022678", "map_id": "WBGene00022678", "name": "sar-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34643", "map_id": "P34643", "name": "sec-16A.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013985", "map_id": "WBGene00013985", "name": "sec-16A.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612883", "map_id": "Q23445", "name": "sar-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612622", "map_id": "none", "name": "SEC16A:SEC16B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612781", "map_id": "none", "name": "TFG hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657197", "map_id": "none", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10649386", "map_id": "none", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612772", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10612652", "map_id": "none", "name": "SAR1B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10612904", "map_id": "none", "name": "SEC23:SEC24", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612774", "map_id": "none", "name": "COPII cargo receptors:SAR1B:GTP:SEC23:SEC24", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10612896", "map_id": "none", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612888", "map_id": "none", "name": "SAR1B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612893", "map_id": "Q21115", "name": "sec-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010496", "map_id": "WBGene00010496", "name": "sec-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649171", "map_id": "none", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612898", "map_id": "Q23368", "name": "sec-24.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612670", "map_id": "Q9U2Z1", "name": "sec-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649169", "map_id": "none", "name": "SEC24A,B:SEC23A:SEC22B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10649345", "map_id": "none", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10649252", "map_id": "none", "name": "BET1:GOSR2:STX5:SCFD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649277", "map_id": "none", "name": "COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649343", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649179", "map_id": "none", "name": "GOLGA2:GORASP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10649267", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10649241", "map_id": "Q20364", "name": "sly-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649258", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649250", "map_id": "none", "name": "STX5,17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10649236", "map_id": "P41941", "name": "memb-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10649234", "map_id": "G5EEU1", "name": "nbet-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10649156", "map_id": "none", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10649153", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10649194", "map_id": "none", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10649192", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10649173", "map_id": "none", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612783", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10649389", "map_id": "none", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10649167", "map_id": "none", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612664", "map_id": "none", "name": "GOSR2,STX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10612666", "map_id": "Q19371", "name": "sec-24.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612672", "map_id": "none", "name": "SEC23A:SEC24C,D:GOSR2,STX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10618547", "map_id": "none", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618543", "map_id": "none", "name": "Adenylate Cyclase V or VI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618528", "map_id": "none", "name": "G-beta:G-gamma (candidates)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618545", "map_id": "none", "name": "Adenylate cyclase type V or VI: G-protein beta gamma Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618534", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10618532", "map_id": "none", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618530", "map_id": "none", "name": "G-alpha(i,o):GTP:G-beta:G-gamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618522", "map_id": "none", "name": "G-alpha(i,o):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618540", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618538", "map_id": "none", "name": "G-alpha(i,o):GDP:G beta:G gamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664419", "map_id": "none", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9033790", "map_id": "CHEBI:139350", "name": "Type 2 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9033793", "map_id": "CHEBI:139351", "name": "H antigen-RBC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10664416", "map_id": "O61739", "name": "FUT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00015019", "map_id": "WBGene00015019", "name": "FUT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664437", "map_id": "none", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9037036", "map_id": "CHEBI:140180", "name": "H antigen-sec", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10664434", "map_id": "O61739", "name": "FUT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10656475", "map_id": "none", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10656463", "map_id": "none", "name": "RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P41934", "map_id": "P41934", "name": "ceh-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000441", "map_id": "WBGene00000441", "name": "ceh-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17694", "map_id": "Q17694", "name": "snpc-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015513", "map_id": "WBGene00015513", "name": "snpc-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91868", "map_id": "P91868", "name": "snpc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001568", "map_id": "WBGene00001568", "name": "snpc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTH5", "map_id": "Q7YTH5", "name": "taf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006390", "map_id": "WBGene00006390", "name": "taf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656472", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657117", "map_id": "none", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29470", "map_id": "CHEBI:37563", "name": "CTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113562", "map_id": "CHEBI:46398", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10657112", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDW9", "map_id": "G5EDW9", "name": "ints-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008361", "map_id": "WBGene00008361", "name": "ints-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30641", "map_id": "P30641", "name": "rpap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011143", "map_id": "WBGene00011143", "name": "rpap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01483", "map_id": "O01483", "name": "ints-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015499", "map_id": "WBGene00015499", "name": "ints-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W6RQY9", "map_id": "W6RQY9", "name": "ints-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022360", "map_id": "WBGene00022360", "name": "ints-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18167", "map_id": "O18167", "name": "ints-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012234", "map_id": "WBGene00012234", "name": "ints-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3K2", "map_id": "Q9U3K2", "name": "ints-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008642", "map_id": "WBGene00008642", "name": "ints-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5Z2V1", "map_id": "A5Z2V1", "name": "cids-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009451", "map_id": "WBGene00009451", "name": "cids-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E5QCH1", "map_id": "E5QCH1", "name": "ints-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013877", "map_id": "WBGene00013877", "name": "ints-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KML7", "map_id": "H2KML7", "name": "ints-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013021", "map_id": "WBGene00013021", "name": "ints-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U267", "map_id": "Q9U267", "name": "ints-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013075", "map_id": "WBGene00013075", "name": "ints-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17749", "map_id": "Q17749", "name": "NABP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015554", "map_id": "WBGene00015554", "name": "NABP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22805", "map_id": "Q22805", "name": "ZC3H8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020827", "map_id": "WBGene00020827", "name": "ZC3H8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZM2", "map_id": "Q95ZM2", "name": "ints-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017608", "map_id": "WBGene00017608", "name": "ints-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44500", "map_id": "O44500", "name": "ints-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019822", "map_id": "WBGene00019822", "name": "ints-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34281", "map_id": "P34281", "name": "cids-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015347", "map_id": "WBGene00015347", "name": "cids-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7WN63", "map_id": "B7WN63", "name": "ints-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000994", "map_id": "WBGene00000994", "name": "ints-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657114", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10656512", "map_id": "none", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10599971", "map_id": "none", "name": "RNA Polymerase II holoenzyme complex (unphosphorylated)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10656465", "map_id": "none", "name": "Initiation factors:CDK7:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657106", "map_id": "none", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10657090", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N4E8", "map_id": "Q9N4E8", "name": "PHAX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022192", "map_id": "WBGene00022192", "name": "PHAX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657098", "map_id": "none", "name": "CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10657092", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10657104", "map_id": "Q22453", "name": "ssup-72", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00020480", "map_id": "WBGene00020480", "name": "ssup-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600765", "map_id": "Q09345", "name": "pcf-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10657202", "map_id": "none", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10610160", "map_id": "Q9N4E8", "name": "PHAX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600248", "map_id": "Q966L5", "name": "SRRT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10656510", "map_id": "none", "name": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10656480", "map_id": "P30641", "name": "rpap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10656504", "map_id": "none", "name": "Homologues of RPRD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10656498", "map_id": "none", "name": "RPRD1A,B:RPRD1A,B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10656508", "map_id": "none", "name": "RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10640732", "map_id": "none", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640717", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640729", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640614", "map_id": "none", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640606", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640608", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640600", "map_id": "none", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640597", "map_id": "none", "name": "EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640694", "map_id": "none", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640690", "map_id": "Q19467", "name": "phospho-git-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10640684", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640692", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640702", "map_id": "none", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640700", "map_id": "none", "name": "RAC1:GTP:PAK1 dimer:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640833", "map_id": "none", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640743", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613352", "map_id": "O01847", "name": "tiam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10640745", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640998", "map_id": "none", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640991", "map_id": "P50605", "name": "phospho-sdn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10640996", "map_id": "none", "name": "p-Y179,Y191-SDC2 cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640764", "map_id": "none", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621901", "map_id": "Q09510", "name": "mlc-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622006", "map_id": "Q09510", "name": "phospho-mlc-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10640612", "map_id": "none", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633823", "map_id": "none", "name": "ARP2/3 complex (ATP bound)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10640610", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640761", "map_id": "none", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640711", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640713", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_114549", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10640709", "map_id": "none", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640706", "map_id": "none", "name": "RAC1-GTP:p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640753", "map_id": "none", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640750", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640994", "map_id": "none", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10640758", "map_id": "none", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608729", "map_id": "Q21430", "name": "pix-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10640766", "map_id": "none", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640715", "map_id": "none", "name": "PAK1/3, 2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640841", "map_id": "none", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640838", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:p-Y179-NGEF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10665741", "map_id": "none", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606498", "map_id": "O17919", "name": "DKC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00010478", "map_id": "WBGene00010478", "name": "DKC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665737", "map_id": "Q9TYM6", "name": "SHQ1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021655", "map_id": "WBGene00021655", "name": "SHQ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10665739", "map_id": "none", "name": "DKC1:SHQ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17919", "map_id": "O17919", "name": "DKC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYM6", "map_id": "Q9TYM6", "name": "SHQ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642188", "map_id": "none", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10642180", "map_id": "none", "name": "POFUT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "O18003", "map_id": "O18003", "name": "sbsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011269", "map_id": "WBGene00011269", "name": "sbsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19305", "map_id": "Q19305", "name": "spon-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006893", "map_id": "WBGene00006893", "name": "spon-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19791", "map_id": "Q19791", "name": "gon-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001650", "map_id": "WBGene00001650", "name": "gon-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19284", "map_id": "Q19284", "name": "THSD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017309", "map_id": "WBGene00017309", "name": "THSD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90884", "map_id": "P90884", "name": "madd-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009958", "map_id": "WBGene00009958", "name": "madd-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642077", "map_id": "none", "name": "O-fuc-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10642185", "map_id": "Q8WR51", "name": "pad-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010757", "map_id": "WBGene00010757", "name": "pad-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625508", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10625415", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "P34501", "map_id": "P34501", "name": "Core 8 (MUC4)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010540", "map_id": "WBGene00010540", "name": "Core 8 (MUC4)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2D6", "map_id": "Q9U2D6", "name": "cnp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012901", "map_id": "WBGene00012901", "name": "cnp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625506", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10625528", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10625526", "map_id": "none", "name": "Core 6 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10625518", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10625516", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10634243", "map_id": "none", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10634238", "map_id": "none", "name": "extended Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10634240", "map_id": "none", "name": "B4GALT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10625644", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10625642", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10625551", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10625536", "map_id": "none", "name": "Core 3 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10625548", "map_id": "none", "name": "B3GNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q20575", "map_id": "Q20575", "name": "B3GNT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009849", "map_id": "WBGene00009849", "name": "B3GNT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19421", "map_id": "Q19421", "name": "B3GNTL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008766", "map_id": "WBGene00008766", "name": "B3GNTL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625655", "map_id": "none", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10625652", "map_id": "none", "name": "Core 4 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10625601", "map_id": "G5EEZ8", "name": "gly-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001640", "map_id": "WBGene00001640", "name": "gly-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642136", "map_id": "none", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_173594", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158602", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10642128", "map_id": "none", "name": "glc-fuc-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10642133", "map_id": "O01878", "name": "B3GALTL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022576", "map_id": "WBGene00022576", "name": "B3GALTL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625634", "map_id": "none", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10625559", "map_id": "none", "name": "Core 1 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10625567", "map_id": "none", "name": "Core 2 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10625631", "map_id": "none", "name": "GCNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q19730", "map_id": "Q19730", "name": "gly-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001643", "map_id": "WBGene00001643", "name": "gly-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP7", "map_id": "G5EDP7", "name": "gly-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001641", "map_id": "WBGene00001641", "name": "gly-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK7", "map_id": "G5EBK7", "name": "gly-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001644", "map_id": "WBGene00001644", "name": "gly-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECK8", "map_id": "G5ECK8", "name": "gly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001626", "map_id": "WBGene00001626", "name": "gly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEZ8", "map_id": "G5EEZ8", "name": "gly-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02315", "map_id": "O02315", "name": "gly-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001642", "map_id": "WBGene00001642", "name": "gly-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625482", "map_id": "none", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10625407", "map_id": "none", "name": "Mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10625479", "map_id": "none", "name": "GALNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9U2C4", "map_id": "Q9U2C4", "name": "gly-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012934", "map_id": "WBGene00012934", "name": "gly-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45293", "map_id": "O45293", "name": "gly-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001633", "map_id": "WBGene00001633", "name": "gly-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K755", "map_id": "Q7K755", "name": "gly-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001636", "map_id": "WBGene00001636", "name": "gly-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45947", "map_id": "O45947", "name": "gly-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001635", "map_id": "WBGene00001635", "name": "gly-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61397", "map_id": "O61397", "name": "gly-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001632", "map_id": "WBGene00001632", "name": "gly-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10634322", "map_id": "none", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10634319", "map_id": "none", "name": "C1GALT1:C1GALT1C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O17747", "map_id": "O17747", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021403", "map_id": "WBGene00021403", "name": "C1GALT1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17053", "map_id": "O17053", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45579", "map_id": "O45579", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44563", "map_id": "O44563", "name": "bus-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044620", "map_id": "WBGene00044620", "name": "bus-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECT3", "map_id": "G5ECT3", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22900", "map_id": "Q22900", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18184", "map_id": "O18184", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18515", "map_id": "Q18515", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16535", "map_id": "O16535", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41881", "map_id": "P41881", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629081", "map_id": "none", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10629043", "map_id": "none", "name": "MR:soluble antigen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_1236715", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10629079", "map_id": "none", "name": "MR:soluble antigen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10629007", "map_id": "none", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171043", "compartment_display": "early endosome lumen" }, { "id": "species_10629005", "map_id": "none", "name": "MR:soluble antigen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10629003", "map_id": "none", "name": "MR/other probable receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10629097", "map_id": "none", "name": "Engulfment of particulate antigen into phagocytic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10629089", "map_id": "none", "name": "Particulate Ag:DC receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10629095", "map_id": "none", "name": "alphaVbeta5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle", "complex": "true" }, { "id": "species_1236714", "map_id": "none", "name": "Exogenous Particulate antigen (Ag)", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle", "complex": "false" }, { "id": "reaction_10629101", "map_id": "none", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1236719", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983036", "map_id": "CHEBI:25676", "name": "precursor peptide fragment (>16 aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942986", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10629083", "map_id": "none", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "reaction_10629099", "map_id": "none", "name": "Interaction of particulate antigens with dendritic cell receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1236726", "map_id": "none", "name": "Exogenous Particulate antigen (Ag)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10629087", "map_id": "none", "name": "Integrin alphaVbeta5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10649526", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10649523", "map_id": "none", "name": "Homologues of AWAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10631021", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10631018", "map_id": "none", "name": "DGAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10630954", "map_id": "none", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498728", "map_id": "CHEBI:17389", "name": "2-MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630949", "map_id": "Q11186", "name": "atgl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10657376", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10657373", "map_id": "none", "name": "DGAT2L6,L7P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10630989", "map_id": "none", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10630956", "map_id": "none", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10630975", "map_id": "none", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10636052", "map_id": "none", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636055", "map_id": "none", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142710", "map_id": "CHEBI:27595", "name": "11epi-PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636060", "map_id": "none", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10636057", "map_id": "none", "name": "HPGDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10614716", "map_id": "none", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614713", "map_id": "none", "name": "PTGES2(88-377), PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661537", "map_id": "none", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_8949232", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8949220", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10661534", "map_id": "none", "name": "MCU complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q21121", "map_id": "Q21121", "name": "mcu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019296", "map_id": "WBGene00019296", "name": "mcu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18874", "map_id": "Q18874", "name": "MICU3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008345", "map_id": "WBGene00008345", "name": "MICU3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3I4", "map_id": "Q9U3I4", "name": "emre-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008980", "map_id": "WBGene00008980", "name": "emre-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ2", "map_id": "Q95PZ2", "name": "micu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013462", "map_id": "WBGene00013462", "name": "micu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661604", "map_id": "none", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10661580", "map_id": "Q9U3I4", "name": "emre-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10661578", "map_id": "none", "name": "C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P50093", "map_id": "P50093", "name": "phb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004015", "map_id": "WBGene00004015", "name": "phb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKU4", "map_id": "Q9BKU4", "name": "phb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3T5", "map_id": "Q9N3T5", "name": "spg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004978", "map_id": "WBGene00004978", "name": "spg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB6", "map_id": "G5EDB6", "name": "ppgn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021425", "map_id": "WBGene00021425", "name": "ppgn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2HQK3", "map_id": "Q2HQK3", "name": "C2orf47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044745", "map_id": "WBGene00044745", "name": "C2orf47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54813", "map_id": "P54813", "name": "ymel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010842", "map_id": "WBGene00010842", "name": "ymel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661582", "map_id": "none", "name": "proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10662558", "map_id": "none", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10661523", "map_id": "Q9U3I4", "name": "emre-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10661513", "map_id": "Q21121", "name": "mcu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10661532", "map_id": "none", "name": "MICU2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10661518", "map_id": "Q95PZ2", "name": "micu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10661511", "map_id": "Q21121", "name": "mcu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10661609", "map_id": "none", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2889072", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_2889083", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10661606", "map_id": "P34322", "name": "ncx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00003572", "map_id": "WBGene00003572", "name": "ncx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661599", "map_id": "none", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10661584", "map_id": "Q9U3I4", "name": "emre-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10661596", "map_id": "none", "name": "Mitochondrial processing peptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q23295", "map_id": "Q23295", "name": "mppb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013880", "map_id": "WBGene00013880", "name": "mppb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN2", "map_id": "Q95XN2", "name": "mppa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022159", "map_id": "WBGene00022159", "name": "mppa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661602", "map_id": "none", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10601291", "map_id": "none", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601287", "map_id": "none", "name": "eIF2B subunits complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34604", "map_id": "P34604", "name": "EIF2B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014221", "map_id": "WBGene00014221", "name": "EIF2B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFF9", "map_id": "G5EFF9", "name": "eif-2bdelta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008670", "map_id": "WBGene00008670", "name": "eif-2bdelta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P80361", "map_id": "P80361", "name": "eif-2Bgamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004090", "map_id": "WBGene00004090", "name": "eif-2Bgamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18994", "map_id": "Q18994", "name": "eif-2bepsilon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008428", "map_id": "WBGene00008428", "name": "eif-2bepsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWD5", "map_id": "Q9XWD5", "name": "eif-2bbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012950", "map_id": "WBGene00012950", "name": "eif-2bbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601248", "map_id": "none", "name": "eIF2:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601289", "map_id": "none", "name": "eIF2:GDP: eIF2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601565", "map_id": "none", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601199", "map_id": "none", "name": "eIF2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10603965", "map_id": "none", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77313", "map_id": "CHEBI:15473", "name": "Crotonoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77251", "map_id": "CHEBI:15453", "name": "3HB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603963", "map_id": "none", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73871", "map_id": "CHEBI:57286", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10644252", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10644249", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A4V0IK35", "map_id": "A0A4V0IK35", "name": "ncs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015867", "map_id": "WBGene00015867", "name": "ncs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45313", "map_id": "O45313", "name": "ncs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008307", "map_id": "WBGene00008307", "name": "ncs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XD1", "map_id": "Q95XD1", "name": "shl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022240", "map_id": "WBGene00022240", "name": "shl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16638", "map_id": "O16638", "name": "ncs-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021116", "map_id": "WBGene00021116", "name": "ncs-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664085", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022660", "map_id": "CHEBI:137038", "name": "18(S)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664090", "map_id": "none", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020583", "map_id": "CHEBI:138387", "name": "18(S)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10618717", "map_id": "none", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618701", "map_id": "none", "name": "Homologues of PLXND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618713", "map_id": "none", "name": "Homologues of SEMA4A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TYS4", "map_id": "Q9TYS4", "name": "smp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004890", "map_id": "WBGene00004890", "name": "smp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17330", "map_id": "Q17330", "name": "smp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004889", "map_id": "WBGene00004889", "name": "smp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XP4", "map_id": "Q95XP4", "name": "mab-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003111", "map_id": "WBGene00003111", "name": "mab-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618715", "map_id": "none", "name": "SEMA4A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618705", "map_id": "none", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10618695", "map_id": "none", "name": "Homologues of SEMA3E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10618703", "map_id": "none", "name": "SEMA3A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621227", "map_id": "none", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621223", "map_id": "none", "name": "Homologues of SEMA7A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621215", "map_id": "none", "name": "Homologues of PLXNC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621225", "map_id": "none", "name": "SEMA7A:PLXNC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615528", "map_id": "none", "name": "SEMA4D interacts with CD45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615507", "map_id": "Q20019", "name": "PTPRC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615524", "map_id": "none", "name": "Homologues of SEMA4D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615526", "map_id": "none", "name": "SEMA4D:PTPRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604168", "map_id": "none", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602616", "map_id": "none", "name": "pol II promoter:TFIID complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602618", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602624", "map_id": "none", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602620", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602622", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604166", "map_id": "none", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10604172", "map_id": "none", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10630113", "map_id": "none", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006694", "map_id": "WBGene00006694", "name": "twk-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629838", "map_id": "none", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629835", "map_id": "none", "name": "TWIK channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21529", "map_id": "Q21529", "name": "twk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006658", "map_id": "WBGene00006658", "name": "twk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90863", "map_id": "P90863", "name": "twk-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006682", "map_id": "WBGene00006682", "name": "twk-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93764", "map_id": "Q93764", "name": "twk-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006684", "map_id": "WBGene00006684", "name": "twk-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AXZ4", "map_id": "A0A0K3AXZ4", "name": "twk-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006665", "map_id": "WBGene00006665", "name": "twk-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEV3", "map_id": "Q9NEV3", "name": "twk-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006696", "map_id": "WBGene00006696", "name": "twk-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23386", "map_id": "Q23386", "name": "twk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006659", "map_id": "WBGene00006659", "name": "twk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629479", "map_id": "none", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629476", "map_id": "none", "name": "Potassium transport channels (Kir 1.1 and Kir 4.1/5.1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629865", "map_id": "none", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629862", "map_id": "none", "name": "TASK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECW6", "map_id": "G5ECW6", "name": "twk-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006673", "map_id": "WBGene00006673", "name": "twk-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17185", "map_id": "O17185", "name": "sup-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006318", "map_id": "WBGene00006318", "name": "sup-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10629773", "map_id": "none", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629770", "map_id": "none", "name": "TREK homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629494", "map_id": "none", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629491", "map_id": "none", "name": "KCNJ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629948", "map_id": "none", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10629945", "map_id": "none", "name": "TRESK homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660945", "map_id": "none", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660941", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660943", "map_id": "none", "name": "MyrG-p-Y419-SRC:RUNX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660953", "map_id": "none", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10662401", "map_id": "none", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662397", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10662399", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10658645", "map_id": "none", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658643", "map_id": "none", "name": "RUNX3:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10662403", "map_id": "none", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10660951", "map_id": "none", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660948", "map_id": "G5EFQ5", "name": "phospho-rnt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615739", "map_id": "none", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615735", "map_id": "none", "name": "Integrins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615737", "map_id": "none", "name": "L1:Integrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621789", "map_id": "none", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621786", "map_id": "none", "name": "pPAK1:Rac1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621774", "map_id": "none", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621359", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10618095", "map_id": "none", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618093", "map_id": "none", "name": "pL1:CK-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621778", "map_id": "none", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621776", "map_id": "none", "name": "L1-EGFR trans-heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615733", "map_id": "none", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615729", "map_id": "C6KRM7", "name": "rig-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615731", "map_id": "none", "name": "L1:NCAM1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614145", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614142", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34644", "map_id": "P34644", "name": "eat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001135", "map_id": "WBGene00001135", "name": "eat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEK1", "map_id": "G5EEK1", "name": "vglu-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010755", "map_id": "WBGene00010755", "name": "vglu-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10046", "map_id": "Q10046", "name": "vglu-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011556", "map_id": "WBGene00011556", "name": "vglu-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614028", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10614135", "map_id": "none", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614088", "map_id": "none", "name": "Docked Glutamate Loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614118", "map_id": "none", "name": "SNARE complex:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614100", "map_id": "none", "name": "Homologues of SLC17A7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613856", "map_id": "none", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10613848", "map_id": "none", "name": "SLC1A1-3,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21353", "map_id": "Q21353", "name": "glt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001621", "map_id": "WBGene00001621", "name": "glt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10901", "map_id": "Q10901", "name": "glt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001620", "map_id": "WBGene00001620", "name": "glt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAY8", "map_id": "Q9UAY8", "name": "glt-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001625", "map_id": "WBGene00001625", "name": "glt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18210", "map_id": "O18210", "name": "glt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001623", "map_id": "WBGene00001623", "name": "glt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21751", "map_id": "Q21751", "name": "glt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001624", "map_id": "WBGene00001624", "name": "glt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613854", "map_id": "H2KZJ7", "name": "praf-3", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017070", "map_id": "WBGene00017070", "name": "praf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614091", "map_id": "none", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614068", "map_id": "P27715", "name": "unc-13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636112", "map_id": "none", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162212", "map_id": "CHEBI:64182", "name": "DeMQ10H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162198", "map_id": "CHEBI:64183", "name": "Q10H2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10636109", "map_id": "O18235", "name": "coq-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000763", "map_id": "WBGene00000763", "name": "coq-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636120", "map_id": "none", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2162214", "map_id": "CHEBI:61011", "name": "all-E-10PrP2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162213", "map_id": "CHEBI:30763", "name": "PHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162207", "map_id": "CHEBI:64136", "name": "DHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10636117", "map_id": "Q8I7J4", "name": "coq-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10636123", "map_id": "none", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162209", "map_id": "CHEBI:50775", "name": "DHDB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162215", "map_id": "CHEBI:50776", "name": "MHDB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10614597", "map_id": "none", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614594", "map_id": "P32756", "name": "cha-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000481", "map_id": "WBGene00000481", "name": "cha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614589", "map_id": "none", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_372511", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_372525", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle lumen", "complex": "false" }, { "id": "species_10614584", "map_id": "none", "name": "Empty Acetylcholine Synaptic Vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34711", "map_id": "P34711", "name": "unc-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006756", "map_id": "WBGene00006756", "name": "unc-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614586", "map_id": "none", "name": "Acetylcholine Loaded Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10614568", "map_id": "P34711", "name": "unc-17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_373334", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10615286", "map_id": "none", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615283", "map_id": "none", "name": "Docked acetylcholine loaded Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615371", "map_id": "none", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615368", "map_id": "P34711", "name": "unc-17", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10645186", "map_id": "none", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10645128", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NEZ7", "map_id": "Q9NEZ7", "name": "bbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000241", "map_id": "WBGene00000241", "name": "bbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21273", "map_id": "Q21273", "name": "BBIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019482", "map_id": "WBGene00019482", "name": "BBIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23049", "map_id": "Q23049", "name": "bbs-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000244", "map_id": "WBGene00000244", "name": "bbs-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5CZ52", "map_id": "Q5CZ52", "name": "bbs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043992", "map_id": "WBGene00043992", "name": "bbs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21626", "map_id": "Q21626", "name": "bbs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010974", "map_id": "WBGene00010974", "name": "bbs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01514", "map_id": "O01514", "name": "bbs-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016744", "map_id": "WBGene00016744", "name": "bbs-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19640", "map_id": "Q19640", "name": "bbs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000242", "map_id": "WBGene00000242", "name": "bbs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18510", "map_id": "Q18510", "name": "arl-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000193", "map_id": "WBGene00000193", "name": "arl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW70", "map_id": "Q9XW70", "name": "osm-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003892", "map_id": "WBGene00003892", "name": "osm-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645178", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "species_10645184", "map_id": "none", "name": "LZTFL1 oligomer:BBSome", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10645954", "map_id": "none", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645950", "map_id": "Q966I6", "name": "rpi-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "WBGene00019536", "map_id": "WBGene00019536", "name": "rpi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645945", "map_id": "none", "name": "ARL3:GTP:UNC119B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "O45379", "map_id": "O45379", "name": "arl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000188", "map_id": "WBGene00000188", "name": "arl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10658", "map_id": "Q10658", "name": "unc-119", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006843", "map_id": "WBGene00006843", "name": "unc-119", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645952", "map_id": "none", "name": "RP2:ARL3:GTP:UNC119B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q966I6", "map_id": "Q966I6", "name": "rpi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645030", "map_id": "none", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10645026", "map_id": "none", "name": "exocyst complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18286", "map_id": "Q18286", "name": "sec-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016188", "map_id": "WBGene00016188", "name": "sec-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18406", "map_id": "Q18406", "name": "sec-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016376", "map_id": "WBGene00016376", "name": "sec-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19262", "map_id": "Q19262", "name": "sec-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017284", "map_id": "WBGene00017284", "name": "sec-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91149", "map_id": "P91149", "name": "exoc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016606", "map_id": "WBGene00016606", "name": "exoc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20678", "map_id": "Q20678", "name": "sec-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018703", "map_id": "WBGene00018703", "name": "sec-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q35", "map_id": "Q95Q35", "name": "exoc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013687", "map_id": "WBGene00013687", "name": "exoc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22706", "map_id": "Q22706", "name": "sec-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004752", "map_id": "WBGene00004752", "name": "sec-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWS2", "map_id": "Q9XWS2", "name": "sec-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004753", "map_id": "WBGene00004753", "name": "sec-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645008", "map_id": "none", "name": "RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "Q9U1S7", "map_id": "Q9U1S7", "name": "pkd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004035", "map_id": "WBGene00004035", "name": "pkd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20759", "map_id": "Q20759", "name": "RAB3IL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010045", "map_id": "WBGene00010045", "name": "RAB3IL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZS6", "map_id": "Q95ZS6", "name": "rfip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018869", "map_id": "WBGene00018869", "name": "rfip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC1", "map_id": "G5EFC1", "name": "rab-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004272", "map_id": "WBGene00004272", "name": "rab-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01803", "map_id": "O01803", "name": "rab-11.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004274", "map_id": "WBGene00004274", "name": "rab-11.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10645028", "map_id": "none", "name": "exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10645054", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10645052", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "reaction_10645964", "map_id": "none", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "reaction_10645097", "map_id": "none", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644745", "map_id": "Q21273", "name": "BBIP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644720", "map_id": "Q5CZ52", "name": "bbs-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644715", "map_id": "Q19640", "name": "bbs-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644735", "map_id": "O01514", "name": "bbs-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644725", "map_id": "Q21626", "name": "bbs-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644710", "map_id": "Q9NEZ7", "name": "bbs-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644740", "map_id": "Q23049", "name": "bbs-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644730", "map_id": "Q9XW70", "name": "osm-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644747", "map_id": "none", "name": "BBSome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10645130", "map_id": "none", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10645126", "map_id": "none", "name": "BBSome ciliary cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10645104", "map_id": "none", "name": "ARL6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10645972", "map_id": "none", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10645958", "map_id": "none", "name": "RP2:ARL3:GDP:UNC119B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10645956", "map_id": "none", "name": "ARL3:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10645943", "map_id": "Q10658", "name": "unc-119", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "reaction_10645961", "map_id": "none", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "reaction_10644756", "map_id": "none", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2132649", "compartment_display": "ciliary basal body" }, { "id": "species_10644752", "map_id": "Q20759", "name": "RAB3IP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10644754", "map_id": "none", "name": "RAB3IP:BBSome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2132649", "compartment_display": "ciliary basal body", "complex": "true" }, { "id": "reaction_10618833", "map_id": "none", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618830", "map_id": "none", "name": "Phosphodiesterases, dual (cAMP, cGMP) activity", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10631241", "map_id": "none", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10631239", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10630704", "map_id": "none", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10630697", "map_id": "none", "name": "GCHFR pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "D6RYD9", "map_id": "D6RYD9", "name": "gfrp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044736", "map_id": "WBGene00044736", "name": "gfrp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630689", "map_id": "none", "name": "GCH1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19980", "map_id": "Q19980", "name": "cat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000298", "map_id": "WBGene00000298", "name": "cat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630699", "map_id": "none", "name": "2GCHFR:GCH1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10655778", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10655775", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XW15", "map_id": "Q9XW15", "name": "APOA1BP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012476", "map_id": "WBGene00012476", "name": "APOA1BP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638217", "map_id": "none", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_199207", "map_id": "CHEBI:15956", "name": "Btn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10638215", "map_id": "none", "name": "ACACA:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602923", "map_id": "none", "name": "Btn-ACACA:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638165", "map_id": "Q9BI98", "name": "bpl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000259", "map_id": "WBGene00000259", "name": "bpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610819", "map_id": "none", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:58017", "name": "PRPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610816", "map_id": "none", "name": "NAPRT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638500", "map_id": "none", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638497", "map_id": "none", "name": "MTRR:MTR(cob(II)alamin)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3149479", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10610781", "map_id": "none", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196834", "map_id": "CHEBI:15769", "name": "PPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196767", "map_id": "CHEBI:16858", "name": "PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610778", "map_id": "none", "name": "3xPPCDC:3xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91988", "map_id": "P91988", "name": "PPCDC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009138", "map_id": "WBGene00009138", "name": "PPCDC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611056", "map_id": "none", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198852", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_198827", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611053", "map_id": "none", "name": "SLC2A1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20734", "map_id": "Q20734", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043980", "map_id": "WBGene00043980", "name": "SLC2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610836", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610833", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9XXM2", "map_id": "Q9XXM2", "name": "nmat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012295", "map_id": "WBGene00012295", "name": "nmat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91851", "map_id": "P91851", "name": "nmat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009176", "map_id": "WBGene00009176", "name": "nmat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630865", "map_id": "none", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10630860", "map_id": "none", "name": "PTPS hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02058", "map_id": "O02058", "name": "ptps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015010", "map_id": "WBGene00015010", "name": "ptps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630712", "map_id": "none", "name": "p-PTPS hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10630862", "map_id": "H2KYN2", "name": "pkg-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10655786", "map_id": "none", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10655783", "map_id": "P32740", "name": "CARKD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00011298", "map_id": "WBGene00011298", "name": "CARKD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660041", "map_id": "none", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_29480", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660038", "map_id": "A3QMB9", "name": "hpo-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00016588", "map_id": "WBGene00016588", "name": "hpo-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610809", "map_id": "none", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610806", "map_id": "none", "name": "2xENPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90755", "map_id": "P90755", "name": "ENPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007755", "map_id": "WBGene00007755", "name": "ENPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643425", "map_id": "none", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10656369", "map_id": "none", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809289", "map_id": "CHEBI:74452", "name": "NMNH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10656366", "map_id": "Q19427", "name": "ndx-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00003586", "map_id": "WBGene00003586", "name": "ndx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638520", "map_id": "none", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159297", "map_id": "CHEBI:18408", "name": "AdoCbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599214", "map_id": "none", "name": "2xMMAA:2xMUT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22111", "map_id": "Q22111", "name": "mmaa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020169", "map_id": "WBGene00020169", "name": "mmaa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23381", "map_id": "Q23381", "name": "mmcm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014202", "map_id": "WBGene00014202", "name": "mmcm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599216", "map_id": "none", "name": "2xMMAA:2xMUT:AdoCbl", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10611068", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611065", "map_id": "none", "name": "CYB5A:heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q93315", "map_id": "Q93315", "name": "cytb-5.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007848", "map_id": "WBGene00007848", "name": "cytb-5.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611063", "map_id": "none", "name": "CYB5A:ferriheme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611568", "map_id": "none", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_200492", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_200499", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10611565", "map_id": "none", "name": "6xNMNAT1:6xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10599221", "map_id": "none", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71009", "map_id": "CHEBI:15465", "name": "L-MM-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10610789", "map_id": "none", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610786", "map_id": "Q22017", "name": "flad-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011271", "map_id": "WBGene00011271", "name": "flad-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638379", "map_id": "none", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638374", "map_id": "Q7Z144", "name": "cblc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022766", "map_id": "WBGene00022766", "name": "cblc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638376", "map_id": "none", "name": "MMACHC:cob(II)alamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7Z144", "map_id": "Q7Z144", "name": "cblc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626242", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965146", "map_id": "CHEBI:18335", "name": "PXAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29390", "map_id": "CHEBI:18405", "name": "PXLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626237", "map_id": "none", "name": "2xPNPO:2xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20939", "map_id": "Q20939", "name": "PNPO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018996", "map_id": "WBGene00018996", "name": "PNPO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638503", "map_id": "none", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3149505", "map_id": "CHEBI:17439", "name": "CNCbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1130611", "map_id": "CHEBI:18407", "name": "HCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10630701", "map_id": "none", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10638549", "map_id": "none", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3165253", "map_id": "CHEBI:17015", "name": "RIB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196931", "map_id": "CHEBI:17015", "name": "RIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638546", "map_id": "none", "name": "SLC52A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q3LFN0", "map_id": "Q3LFN0", "name": "rft-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044637", "map_id": "WBGene00044637", "name": "rft-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4SDH4", "map_id": "G4SDH4", "name": "rft-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021626", "map_id": "WBGene00021626", "name": "rft-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626228", "map_id": "none", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965053", "map_id": "CHEBI:16709", "name": "PDX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_964952", "map_id": "CHEBI:28803", "name": "PDXP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626223", "map_id": "none", "name": "2xPDXK:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611047", "map_id": "none", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611044", "map_id": "none", "name": "GSTO dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638491", "map_id": "none", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638483", "map_id": "Q9XWC9", "name": "MMADHC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013577", "map_id": "WBGene00013577", "name": "MMADHC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638485", "map_id": "none", "name": "MMACHC:MMADHC:cob(II)alamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XWC9", "map_id": "Q9XWC9", "name": "MMADHC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639602", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639600", "map_id": "none", "name": "hCBXs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17732", "map_id": "O17732", "name": "pyc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004258", "map_id": "WBGene00004258", "name": "pyc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20676", "map_id": "Q20676", "name": "pccb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018701", "map_id": "WBGene00018701", "name": "pccb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19842", "map_id": "Q19842", "name": "pcca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017864", "map_id": "WBGene00017864", "name": "pcca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638369", "map_id": "none", "name": "hCBXs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10610846", "map_id": "none", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610843", "map_id": "none", "name": "NADSYN1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXK6", "map_id": "Q9XXK6", "name": "qns-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007698", "map_id": "WBGene00007698", "name": "qns-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659491", "map_id": "none", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659488", "map_id": "none", "name": "Homologues of SLC22A13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10611255", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611252", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626163", "map_id": "none", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947703", "map_id": "CHEBI:17319", "name": "dADE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947537", "map_id": "CHEBI:59648", "name": "Precursor Z", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626160", "map_id": "none", "name": "holo-MOCS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20624", "map_id": "Q20624", "name": "moc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009885", "map_id": "WBGene00009885", "name": "moc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610799", "map_id": "none", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610796", "map_id": "none", "name": "2xTRAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01320", "map_id": "O01320", "name": "ACP5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008531", "map_id": "WBGene00008531", "name": "ACP5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610771", "map_id": "none", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610768", "map_id": "none", "name": "2xTPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P30636", "map_id": "P30636", "name": "tpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014027", "map_id": "WBGene00014027", "name": "tpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662637", "map_id": "none", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10662634", "map_id": "none", "name": "NADK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XXI5", "map_id": "Q9XXI5", "name": "nadk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012463", "map_id": "WBGene00012463", "name": "nadk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626240", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10638489", "map_id": "none", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638487", "map_id": "none", "name": "MMACHC:MMADHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626226", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964945", "map_id": "CHEBI:16410", "name": "PXA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617657", "map_id": "none", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389556", "map_id": "CHEBI:18009", "name": "NADP+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389548", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113602", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617654", "map_id": "none", "name": "IDH1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10611561", "map_id": "none", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8938083", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938090", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611558", "map_id": "none", "name": "4xNMNAT3:4xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10611139", "map_id": "none", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611131", "map_id": "P91871", "name": "fasn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611136", "map_id": "Q22856", "name": "AASDHPPT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012142", "map_id": "WBGene00012142", "name": "AASDHPPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630715", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10638168", "map_id": "none", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638154", "map_id": "none", "name": "6x(PCCA:PCCB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638160", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638207", "map_id": "none", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638200", "map_id": "none", "name": "4x(PC:Mn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638205", "map_id": "none", "name": "4x(Btn-PC:Mn2+)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626116", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626113", "map_id": "Q21657", "name": "mocs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010983", "map_id": "WBGene00010983", "name": "mocs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638508", "map_id": "none", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3149564", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10620516", "map_id": "none", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429739", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429748", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620513", "map_id": "Q23616", "name": "SLC5A8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10610761", "map_id": "none", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196786", "map_id": "CHEBI:15905", "name": "PPanK", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610758", "map_id": "none", "name": "2xPPCS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BL36", "map_id": "Q9BL36", "name": "PPCS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022171", "map_id": "WBGene00022171", "name": "PPCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638576", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638573", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61198", "map_id": "O61198", "name": "AOX1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017487", "map_id": "WBGene00017487", "name": "AOX1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17892", "map_id": "O17892", "name": "xdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010083", "map_id": "WBGene00010083", "name": "xdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960A1", "map_id": "Q960A1", "name": "gad-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015057", "map_id": "WBGene00015057", "name": "gad-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611119", "map_id": "none", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611116", "map_id": "none", "name": "SLC23A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O18061", "map_id": "O18061", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021994", "map_id": "WBGene00021994", "name": "SLC23A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G8JZM6", "map_id": "G8JZM6", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18057", "map_id": "O18057", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D6RYE3", "map_id": "D6RYE3", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYX7", "map_id": "Q9TYX7", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18771", "map_id": "Q18771", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10641004", "map_id": "none", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10641002", "map_id": "none", "name": "ACACB:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10611528", "map_id": "none", "name": "Btn-ACACB:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10626139", "map_id": "none", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626123", "map_id": "none", "name": "MOCS3:Zn2+ (red.)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44510", "map_id": "O44510", "name": "moc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018357", "map_id": "WBGene00018357", "name": "moc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626128", "map_id": "none", "name": "MOCS3-S-S(1-):Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626136", "map_id": "none", "name": "PXLP-K258-NFS1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61741", "map_id": "O61741", "name": "nfs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015021", "map_id": "WBGene00015021", "name": "nfs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638578", "map_id": "none", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638495", "map_id": "none", "name": "MTRR:MTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626230", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10638518", "map_id": "none", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159274", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10638515", "map_id": "none", "name": "3xMMAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18218", "map_id": "Q18218", "name": "mmab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016144", "map_id": "WBGene00016144", "name": "mmab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638506", "map_id": "none", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10626151", "map_id": "none", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947496", "map_id": "CHEBI:58698", "name": "MPT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947561", "map_id": "CHEBI:36264", "name": "MoO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626148", "map_id": "none", "name": "3xGPHN:3xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGH2", "map_id": "G5EGH2", "name": "moc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003384", "map_id": "WBGene00003384", "name": "moc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638382", "map_id": "none", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000125", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10614852", "map_id": "Q9U2G5", "name": "mrp-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003413", "map_id": "WBGene00003413", "name": "mrp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638196", "map_id": "none", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638190", "map_id": "none", "name": "6xMCCC1:6xMCCC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10638194", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10661102", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10644423", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644420", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660839", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660834", "map_id": "none", "name": "H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660836", "map_id": "none", "name": "H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661819", "map_id": "none", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661812", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95Y80", "map_id": "Q95Y80", "name": "bet-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022473", "map_id": "WBGene00022473", "name": "bet-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661816", "map_id": "none", "name": "RUNX3:CBFB:CCND1:HDAC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661749", "map_id": "none", "name": "BRD2 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660958", "map_id": "none", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638691", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09646", "map_id": "Q09646", "name": "ham-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044072", "map_id": "WBGene00044072", "name": "ham-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF53", "map_id": "G5EF53", "name": "swsn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004204", "map_id": "WBGene00004204", "name": "swsn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H8ESF3", "map_id": "H8ESF3", "name": "swsn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004203", "map_id": "WBGene00004203", "name": "swsn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21831", "map_id": "Q21831", "name": "snfc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011111", "map_id": "WBGene00011111", "name": "snfc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "J7SA49", "map_id": "J7SA49", "name": "let-526", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002717", "map_id": "WBGene00002717", "name": "let-526", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4N4", "map_id": "Q9N4N4", "name": "swsn-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022774", "map_id": "WBGene00022774", "name": "swsn-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91094", "map_id": "P91094", "name": "pqn-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004106", "map_id": "WBGene00004106", "name": "pqn-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEY5", "map_id": "G5EEY5", "name": "pbrm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007042", "map_id": "WBGene00007042", "name": "pbrm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09441", "map_id": "Q09441", "name": "ARID2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007433", "map_id": "WBGene00007433", "name": "ARID2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL39", "map_id": "Q9BL39", "name": "swsn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022182", "map_id": "WBGene00022182", "name": "swsn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02101", "map_id": "O02101", "name": "swsn-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015971", "map_id": "WBGene00015971", "name": "swsn-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660956", "map_id": "none", "name": "RUNX1:CBFB:SWI/SNF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663484", "map_id": "none", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660385", "map_id": "none", "name": "RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10663429", "map_id": "none", "name": "p-S451-RUNX2:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660771", "map_id": "none", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660760", "map_id": "none", "name": "RUNX1:CBFB:PRMT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661041", "map_id": "none", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661037", "map_id": "none", "name": "Homologues of PAX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21263", "map_id": "Q21263", "name": "pax-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003938", "map_id": "WBGene00003938", "name": "pax-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED14", "map_id": "G5ED14", "name": "egl-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001204", "map_id": "WBGene00001204", "name": "egl-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661039", "map_id": "none", "name": "RUNX1:CBFB:PAX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660769", "map_id": "none", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660766", "map_id": "none", "name": "MeR206,MeR210-RUNX1:CBFB:PRMT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661097", "map_id": "none", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661087", "map_id": "none", "name": "RUNX2:SCF(SKP2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661092", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10660861", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660856", "map_id": "none", "name": "H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660858", "map_id": "none", "name": "H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663499", "map_id": "none", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663486", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10663490", "map_id": "none", "name": "RUNX2:STUB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660823", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660807", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A5JYW9", "map_id": "A5JYW9", "name": "sin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004117", "map_id": "WBGene00004117", "name": "sin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660820", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661089", "map_id": "none", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660379", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10661731", "map_id": "none", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661729", "map_id": "none", "name": "RUNX3:CBFB:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661099", "map_id": "none", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10664948", "map_id": "none", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611175", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10664946", "map_id": "none", "name": "FOXO4:ATXN3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660832", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660827", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660829", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10635481", "map_id": "none", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635477", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10663497", "map_id": "none", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663492", "map_id": "G5EFQ5", "name": "rnt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10659819", "map_id": "none", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635483", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10659817", "map_id": "none", "name": "TEAD2:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10635592", "map_id": "none", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635588", "map_id": "none", "name": "Homologues of TBX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8TA81", "map_id": "Q8TA81", "name": "TBX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022695", "map_id": "WBGene00022695", "name": "TBX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1T6W8", "map_id": "Q1T6W8", "name": "tbx-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044798", "map_id": "WBGene00044798", "name": "tbx-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20257", "map_id": "Q20257", "name": "tbx-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006547", "map_id": "WBGene00006547", "name": "tbx-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45291", "map_id": "O45291", "name": "tbx-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006552", "map_id": "WBGene00006552", "name": "tbx-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA55", "map_id": "Q9NA55", "name": "tbx-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006559", "map_id": "WBGene00006559", "name": "tbx-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02073", "map_id": "O02073", "name": "sea-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004750", "map_id": "WBGene00004750", "name": "sea-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2K7", "map_id": "Q9N2K7", "name": "tbx-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006549", "map_id": "WBGene00006549", "name": "tbx-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA56", "map_id": "Q9NA56", "name": "tbx-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006558", "map_id": "WBGene00006558", "name": "tbx-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAH2", "map_id": "Q9NAH2", "name": "tbx-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006553", "map_id": "WBGene00006553", "name": "tbx-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09376", "map_id": "Q09376", "name": "tbx-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006554", "map_id": "WBGene00006554", "name": "tbx-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61764", "map_id": "O61764", "name": "tbx-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006551", "map_id": "WBGene00006551", "name": "tbx-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PX3", "map_id": "Q95PX3", "name": "tbx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006544", "map_id": "WBGene00006544", "name": "tbx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVD5", "map_id": "Q9XVD5", "name": "tbx-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006557", "map_id": "WBGene00006557", "name": "tbx-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23622", "map_id": "Q23622", "name": "tbx-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006555", "map_id": "WBGene00006555", "name": "tbx-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2C9", "map_id": "Q9U2C9", "name": "tbx-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006556", "map_id": "WBGene00006556", "name": "tbx-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22292", "map_id": "Q22292", "name": "tbx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006545", "map_id": "WBGene00006545", "name": "tbx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZL0", "map_id": "Q9TZL0", "name": "tbx-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006550", "map_id": "WBGene00006550", "name": "tbx-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22289", "map_id": "Q22289", "name": "tbx-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006546", "map_id": "WBGene00006546", "name": "tbx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10635496", "map_id": "Q9N3S7", "name": "pcaf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10635590", "map_id": "none", "name": "TBX5:WWTR1:PCAF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660962", "map_id": "none", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660960", "map_id": "none", "name": "RUNX1:CBFB:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664997", "map_id": "none", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10664992", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10664994", "map_id": "none", "name": "KAT2B,(EP300)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_3785707", "map_id": "CHEBI:26523", "name": "ROS", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10664901", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664897", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664899", "map_id": "none", "name": "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660805", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660796", "map_id": "none", "name": "H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660802", "map_id": "none", "name": "H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660877", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660872", "map_id": "none", "name": "H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660874", "map_id": "none", "name": "H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10635491", "map_id": "none", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635489", "map_id": "none", "name": "TEAD:WWTR1(TAZ)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660884", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660879", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660881", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10663445", "map_id": "none", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10663437", "map_id": "none", "name": "p-S432-RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10663442", "map_id": "Q95XK4", "name": "ppm-1.d", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021856", "map_id": "WBGene00021856", "name": "ppm-1.d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660389", "map_id": "none", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660383", "map_id": "none", "name": "p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660387", "map_id": "none", "name": "RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664907", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664903", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,SFN dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664905", "map_id": "none", "name": "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665000", "map_id": "none", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10664952", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10664950", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660426", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660419", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661025", "map_id": "none", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661021", "map_id": "none", "name": "Homologues of ELF2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O01521", "map_id": "O01521", "name": "ELF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017598", "map_id": "WBGene00017598", "name": "ELF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01519", "map_id": "O01519", "name": "ets-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017601", "map_id": "WBGene00017601", "name": "ets-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661023", "map_id": "none", "name": "RUNX1:CBFB:ELF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664911", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664883", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10664909", "map_id": "none", "name": "p-T32,S197,S262-FOXO4:YWHAZ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659823", "map_id": "none", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635487", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10659821", "map_id": "none", "name": "TEAD4:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660224", "map_id": "none", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660220", "map_id": "Q86MF0", "name": "fkh-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001439", "map_id": "WBGene00001439", "name": "fkh-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660222", "map_id": "none", "name": "RUNX1:CBFB:FOXP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86MF0", "map_id": "Q86MF0", "name": "fkh-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661755", "map_id": "none", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661739", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661751", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300:BRD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10661753", "map_id": "none", "name": "KRAS:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10662820", "map_id": "none", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662817", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648106", "map_id": "P03949", "name": "phospho-abl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10664885", "map_id": "none", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10660424", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660408", "map_id": "none", "name": "RUNX1:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660421", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB:p-S,T-EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660428", "map_id": "none", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10659827", "map_id": "none", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10635485", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10659825", "map_id": "none", "name": "TEAD3:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10660868", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10660863", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10660865", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661814", "map_id": "none", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10661810", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10661742", "map_id": "none", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10662813", "map_id": "none", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662811", "map_id": "none", "name": "RUNX1:CBFB:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657931", "map_id": "none", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10657923", "map_id": "Q19937", "name": "tab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006380", "map_id": "WBGene00006380", "name": "tab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657927", "map_id": "none", "name": "CTNNB1:TCF7L2,LEF1:CCND1 Gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10657929", "map_id": "none", "name": "VENTX:TCF4,LEF1:CCND1 Gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19937", "map_id": "Q19937", "name": "tab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665048", "map_id": "none", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10665046", "map_id": "none", "name": "FOXO1:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10644162", "map_id": "none", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643385", "map_id": "Q9TXR4", "name": "msh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003418", "map_id": "WBGene00003418", "name": "msh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643390", "map_id": "Q9N3T8", "name": "msh-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003422", "map_id": "WBGene00003422", "name": "msh-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643405", "map_id": "none", "name": "MSH2:MSH6:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N3T8", "map_id": "Q9N3T8", "name": "msh-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXR4", "map_id": "Q9TXR4", "name": "msh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644164", "map_id": "none", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643378", "map_id": "G5EFG5", "name": "pms-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004064", "map_id": "WBGene00004064", "name": "pms-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643373", "map_id": "Q9XU10", "name": "mlh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003373", "map_id": "WBGene00003373", "name": "mlh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643380", "map_id": "none", "name": "MLH1:PMS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFG5", "map_id": "G5EFG5", "name": "pms-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU10", "map_id": "Q9XU10", "name": "mlh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643409", "map_id": "none", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358514", "map_id": "none", "name": "DNA containing mismatch or 1-2 base IDL", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10643407", "map_id": "none", "name": "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643422", "map_id": "none", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643394", "map_id": "none", "name": "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643398", "map_id": "none", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643396", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10643420", "map_id": "none", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10643416", "map_id": "O62245", "name": "exo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009731", "map_id": "WBGene00009731", "name": "exo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10643400", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10643418", "map_id": "none", "name": "EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62245", "map_id": "O62245", "name": "exo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643403", "map_id": "none", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10618428", "map_id": "none", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618352", "map_id": "none", "name": "CRMP's tetramers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618374", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:pCdk5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECH7", "map_id": "G5ECH7", "name": "phospho-cdk-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000407", "map_id": "WBGene00000407", "name": "phospho-cdk-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22695", "map_id": "Q22695", "name": "cdka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011955", "map_id": "WBGene00011955", "name": "cdka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618425", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618502", "map_id": "none", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618499", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618464", "map_id": "none", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618238", "map_id": "none", "name": "Sema3A:NRP-1:pPlexin-A:Fyn:Fes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22243", "map_id": "Q22243", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022780", "map_id": "WBGene00022780", "name": "FER", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ80", "map_id": "H2KZ80", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D6R8W4", "map_id": "D6R8W4", "name": "kin-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002206", "map_id": "WBGene00002206", "name": "kin-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19726", "map_id": "Q19726", "name": "kin-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002198", "map_id": "WBGene00002198", "name": "kin-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H8ESG3", "map_id": "H8ESG3", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23554", "map_id": "Q23554", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01774", "map_id": "O01774", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBM6", "map_id": "G5EBM6", "name": "kin-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002204", "map_id": "WBGene00002204", "name": "kin-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91360", "map_id": "P91360", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18865", "map_id": "Q18865", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20933", "map_id": "Q20933", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXI2", "map_id": "Q9TXI2", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZG1", "map_id": "Q9GZG1", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23102", "map_id": "Q23102", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3B5", "map_id": "Q9U3B5", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21764", "map_id": "Q21764", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2T8", "map_id": "Q9U2T8", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4S6", "map_id": "Q9N4S6", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22146", "map_id": "Q22146", "name": "frk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001487", "map_id": "WBGene00001487", "name": "frk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC46", "map_id": "G5EC46", "name": "kin-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002193", "map_id": "WBGene00002193", "name": "kin-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22765", "map_id": "Q22765", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19704", "map_id": "Q19704", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0S4FT70", "map_id": "A0A0S4FT70", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYX4", "map_id": "Q9TYX4", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22245", "map_id": "Q22245", "name": "kin-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002208", "map_id": "WBGene00002208", "name": "kin-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18142", "map_id": "Q18142", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A061ADQ6", "map_id": "A0A061ADQ6", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW34", "map_id": "Q9XW34", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02064", "map_id": "O02064", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618461", "map_id": "none", "name": "Sema3A:NP-1:Plexin-A:Fes:CRMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613594", "map_id": "none", "name": "Homologues of FER", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599289", "map_id": "none", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599286", "map_id": "none", "name": "PAH:Fe2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90925", "map_id": "P90925", "name": "pah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000240", "map_id": "WBGene00000240", "name": "pah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599309", "map_id": "none", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71129", "map_id": "CHEBI:20680", "name": "qDHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599306", "map_id": "none", "name": "PCBD1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TZH6", "map_id": "Q9TZH6", "name": "pcbd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020397", "map_id": "WBGene00020397", "name": "pcbd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599299", "map_id": "none", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599296", "map_id": "none", "name": "QDPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ3", "map_id": "Q9XVJ3", "name": "qdpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011398", "map_id": "WBGene00011398", "name": "qdpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625266", "map_id": "none", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893599", "map_id": "CHEBI:29750", "name": "3IN-PYRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10639641", "map_id": "none", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639638", "map_id": "none", "name": "PRDX6:GSTP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639334", "map_id": "none", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3299683", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10639331", "map_id": "none", "name": "SOD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P31161", "map_id": "P31161", "name": "sod-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004931", "map_id": "WBGene00004931", "name": "sod-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639365", "map_id": "none", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3299686", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10639362", "map_id": "none", "name": "SOD3 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q27538", "map_id": "Q27538", "name": "sod-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007036", "map_id": "WBGene00007036", "name": "sod-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34461", "map_id": "P34461", "name": "sod-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004933", "map_id": "WBGene00004933", "name": "sod-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34697", "map_id": "P34697", "name": "sod-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004930", "map_id": "WBGene00004930", "name": "sod-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649479", "map_id": "none", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696199", "map_id": "CHEBI:15883", "name": "GP4G", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696194", "map_id": "CHEBI:58115", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649476", "map_id": "Q9U2M7", "name": "ndx-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00003581", "map_id": "WBGene00003581", "name": "ndx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639564", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10639561", "map_id": "none", "name": "PRDX3 dodecamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21824", "map_id": "Q21824", "name": "prdx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011110", "map_id": "WBGene00011110", "name": "prdx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639577", "map_id": "none", "name": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1655882", "map_id": "CHEBI:17858", "name": "GSSG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10639574", "map_id": "none", "name": "GPX1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95003", "map_id": "Q95003", "name": "gpx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007517", "map_id": "WBGene00007517", "name": "gpx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2X2", "map_id": "Q9N2X2", "name": "gpx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022377", "map_id": "WBGene00022377", "name": "gpx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639589", "map_id": "none", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10639586", "map_id": "none", "name": "TXNRD2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P30635", "map_id": "P30635", "name": "trxr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014028", "map_id": "WBGene00014028", "name": "trxr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639598", "map_id": "none", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10639595", "map_id": "none", "name": "GSR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10640254", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10640251", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "reaction_10639375", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10639372", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10639607", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10606530", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606528", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603119", "map_id": "none", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10603116", "map_id": "none", "name": "CAT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10641727", "map_id": "none", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10641725", "map_id": "none", "name": "SOD3 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10599744", "map_id": "none", "name": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599741", "map_id": "none", "name": "GPX1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10649557", "map_id": "none", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649551", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649553", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649555", "map_id": "none", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648323", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648696", "map_id": "none", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10641259", "map_id": "none", "name": "Homologues of CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648255", "map_id": "Q23451", "name": "rad-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648694", "map_id": "none", "name": "XPC:RAD23:CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649835", "map_id": "none", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648742", "map_id": "none", "name": "XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648744", "map_id": "none", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5688114", "map_id": "none", "name": "Distorted dsDNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648740", "map_id": "none", "name": "UV-DDB:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N425", "map_id": "Q9N425", "name": "csn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000815", "map_id": "WBGene00000815", "name": "csn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ0", "map_id": "Q95PZ0", "name": "csn-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000818", "map_id": "WBGene00000818", "name": "csn-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GS00", "map_id": "Q9GS00", "name": "csn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000813", "map_id": "WBGene00000813", "name": "csn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N359", "map_id": "Q9N359", "name": "csn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000816", "map_id": "WBGene00000816", "name": "csn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91001", "map_id": "P91001", "name": "csn-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000817", "map_id": "WBGene00000817", "name": "csn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01422", "map_id": "O01422", "name": "csn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000814", "map_id": "WBGene00000814", "name": "csn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648738", "map_id": "none", "name": "COP9 signalosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10633715", "map_id": "none", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2023856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10633712", "map_id": "none", "name": "PL(C)D4:3xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q21754", "map_id": "Q21754", "name": "plc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004039", "map_id": "WBGene00004039", "name": "plc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633605", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633602", "map_id": "none", "name": "PLCbz", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633496", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633493", "map_id": "none", "name": "ITPKA/B/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95Q62", "map_id": "Q95Q62", "name": "lfe-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002979", "map_id": "WBGene00002979", "name": "lfe-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633721", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633580", "map_id": "none", "name": "INPP5(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17590", "map_id": "O17590", "name": "ocrl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGN9", "map_id": "G5EGN9", "name": "inpp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012016", "map_id": "WBGene00012016", "name": "inpp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECL2", "map_id": "G5ECL2", "name": "unc-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006763", "map_id": "WBGene00006763", "name": "unc-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34370", "map_id": "P34370", "name": "cil-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00086546", "map_id": "WBGene00086546", "name": "cil-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633745", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633742", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFI8", "map_id": "G5EFI8", "name": "plc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004036", "map_id": "WBGene00004036", "name": "plc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633663", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633660", "map_id": "none", "name": "PTEN:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633682", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633677", "map_id": "O17590", "name": "ocrl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615561", "map_id": "none", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615530", "map_id": "none", "name": "SEMA4D dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615546", "map_id": "none", "name": "Plexin-B1:ErbB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615558", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615698", "map_id": "none", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615694", "map_id": "Q9XWK4", "name": "RANBP9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615696", "map_id": "none", "name": "L1:RanBPM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615677", "map_id": "none", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615453", "map_id": "none", "name": "DCC:NTN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34710", "map_id": "P34710", "name": "unc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "unc-6", "map_id": "unc-6", "name": "unc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615673", "map_id": "Q965X6", "name": "siah-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021369", "map_id": "WBGene00021369", "name": "siah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615675", "map_id": "none", "name": "NTN1:DCC:SIAH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q965X6", "map_id": "Q965X6", "name": "siah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658154", "map_id": "none", "name": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658145", "map_id": "none", "name": "RELN:VLDLR:DAB1:SH3KBP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7JP80", "map_id": "Q7JP80", "name": "VLDLR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020481", "map_id": "WBGene00020481", "name": "VLDLR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658152", "map_id": "none", "name": "RELN:VLDLR:p-Y198,220,232-DAB1:SH3KBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618622", "map_id": "none", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618613", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618615", "map_id": "none", "name": "ARHGEF11,ARHGEF12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618617", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615963", "map_id": "none", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615959", "map_id": "none", "name": "Collagen alpha-3(IV):Collagen alpha-4(IV):Collagen alpha-5(IV) triple helix", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10615961", "map_id": "none", "name": "NCAM-1:Collagen complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618620", "map_id": "none", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10663513", "map_id": "none", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2299699", "map_id": "CHEBI:60924", "name": "Keratan sulfate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10663511", "map_id": "none", "name": "SLIT2,(SLIT3):Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10618951", "map_id": "none", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615741", "map_id": "none", "name": "NTN1:DCC oligomer:p-Y397-PTK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615743", "map_id": "none", "name": "NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615457", "map_id": "none", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615440", "map_id": "G5EF96", "name": "unc-40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615455", "map_id": "none", "name": "NTN1:DCC oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618943", "map_id": "none", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618938", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10617638", "map_id": "none", "name": "CDC42:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618940", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615459", "map_id": "none", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615451", "map_id": "P34710", "name": "unc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10624235", "map_id": "none", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624231", "map_id": "none", "name": "DCC, UNC5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q26261", "map_id": "Q26261", "name": "unc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006745", "map_id": "WBGene00006745", "name": "unc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624224", "map_id": "O44565", "name": "lam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10624233", "map_id": "none", "name": "NTN4:DCC,UNC5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618294", "map_id": "none", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618273", "map_id": "O17905", "name": "frm-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10618290", "map_id": "none", "name": "PIP5K1gamma:Talin-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618292", "map_id": "none", "name": "FARP2:PIP5KIgamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618595", "map_id": "none", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618584", "map_id": "none", "name": "R-Ras-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBK8", "map_id": "G5EBK8", "name": "ras-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004310", "map_id": "WBGene00004310", "name": "ras-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618586", "map_id": "none", "name": "R-Ras-GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618592", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616046", "map_id": "none", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616020", "map_id": "none", "name": "Homologues of DSCAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616042", "map_id": "none", "name": "p-S144-PAK1:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10616044", "map_id": "none", "name": "DSCAM:p-S144-PAK1:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618605", "map_id": "none", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618602", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618949", "map_id": "none", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618936", "map_id": "G5EEN3", "name": "ced-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615485", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618564", "map_id": "none", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618560", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618562", "map_id": "none", "name": "Sema4D:pPlexin-B1:Met:RAC1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618025", "map_id": "none", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618020", "map_id": "none", "name": "Grb2:Sos:pFAK bound to NCAM1:pFyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615659", "map_id": "none", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615655", "map_id": "none", "name": "p-T567-EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10615657", "map_id": "none", "name": "DCC:p-T567-EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616034", "map_id": "none", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616030", "map_id": "none", "name": "DSCAM, DSCAML1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10616032", "map_id": "none", "name": "DSCAM/DSCAML1 homodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615967", "map_id": "none", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_114570", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10615965", "map_id": "none", "name": "NCAM-1:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618022", "map_id": "none", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618014", "map_id": "none", "name": "Grb2:pFAK bound to NCAM1:pFyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618016", "map_id": "none", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618010", "map_id": "none", "name": "Multiple phosphorylated FAK bound to NCAM:pFyn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618955", "map_id": "none", "name": "Recruitment and activation of N-WASP by Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612328", "map_id": "Q8I4M6", "name": "N-WASP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10618953", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10663935", "map_id": "none", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10663933", "map_id": "none", "name": "ROBO1,ROBO2:Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615746", "map_id": "none", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615483", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615650", "map_id": "none", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615646", "map_id": "G5EBK3", "name": "erm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615648", "map_id": "none", "name": "EZR:PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618996", "map_id": "none", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618993", "map_id": "none", "name": "Plexin-B1:Met", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618318", "map_id": "none", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618242", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618315", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660741", "map_id": "none", "name": "LYPLA2 hydrolyses PALM-C3,4-GAP43", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660731", "map_id": "Q20199", "name": "PALM-C3,4-GAP43", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00018214", "map_id": "WBGene00018214", "name": "GAP43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660733", "map_id": "Q20199", "name": "GAP43", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10660738", "map_id": "A0A061ACY0", "name": "ath-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10622809", "map_id": "none", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622806", "map_id": "none", "name": "MAP kinase p38 (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618607", "map_id": "none", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618600", "map_id": "O45611", "name": "rga-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615487", "map_id": "none", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10615671", "map_id": "none", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615667", "map_id": "Q965X6", "name": "siah-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615669", "map_id": "none", "name": "NTN1:DCC:SIAH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618283", "map_id": "none", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618208", "map_id": "none", "name": "Sema3A dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10618277", "map_id": "none", "name": "NRP1:PlexinA1-4:FARP2:FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10618281", "map_id": "none", "name": "Sema3A:Nrp-1:Plexin A:Fyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615500", "map_id": "none", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615494", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615496", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615498", "map_id": "none", "name": "NFASC:NRCAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615662", "map_id": "none", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612166", "map_id": "P34722", "name": "phospho-tpa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10622784", "map_id": "none", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10618244", "map_id": "none", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618240", "map_id": "none", "name": "Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612171", "map_id": "none", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612168", "map_id": "none", "name": "Active PKC theta bound to DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10603943", "map_id": "none", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77276", "map_id": "CHEBI:27466", "name": "(S)-3-Hydroxytetradecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77269", "map_id": "CHEBI:28726", "name": "3-Oxotetradecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603937", "map_id": "none", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77261", "map_id": "CHEBI:15521", "name": "LAU-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603940", "map_id": "none", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77273", "map_id": "CHEBI:27721", "name": "trans-Tetradec-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10606622", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29790", "map_id": "CHEBI:57737", "name": "XY5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78346", "name": "R5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599506", "map_id": "none", "name": "TKT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17759", "map_id": "O17759", "name": "tkt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008506", "map_id": "WBGene00008506", "name": "tkt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606632", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606636", "map_id": "none", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599516", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q966C7", "map_id": "Q966C7", "name": "tald-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021286", "map_id": "WBGene00021286", "name": "tald-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610356", "map_id": "none", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10610348", "map_id": "none", "name": "dimerized CEL:bile salt complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10610351", "map_id": "none", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171076", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171149", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10662935", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10662932", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q20449", "map_id": "Q20449", "name": "lipl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009773", "map_id": "WBGene00009773", "name": "lipl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2S7J2", "map_id": "E2S7J2", "name": "lipl-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021963", "map_id": "WBGene00021963", "name": "lipl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94252", "map_id": "Q94252", "name": "lipl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019376", "map_id": "WBGene00019376", "name": "lipl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61866", "map_id": "O61866", "name": "lipl-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022642", "map_id": "WBGene00022642", "name": "lipl-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93789", "map_id": "Q93789", "name": "lipl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010062", "map_id": "WBGene00010062", "name": "lipl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U276", "map_id": "Q9U276", "name": "lipl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013050", "map_id": "WBGene00013050", "name": "lipl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17766", "map_id": "O17766", "name": "lipl-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008510", "map_id": "WBGene00008510", "name": "lipl-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16956", "map_id": "O16956", "name": "lipl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020016", "map_id": "WBGene00020016", "name": "lipl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610354", "map_id": "none", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10646460", "map_id": "none", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661268", "map_id": "CHEBI:13115", "name": "L-gulonate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661262", "map_id": "CHEBI:57655", "name": "3-dehydro-L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646457", "map_id": "none", "name": "CRYL1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C0VXV5", "map_id": "C0VXV5", "name": "CRYL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022130", "map_id": "WBGene00022130", "name": "CRYL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646450", "map_id": "none", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5660036", "map_id": "CHEBI:17399", "name": "L-xylulose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5660033", "map_id": "CHEBI:17151", "name": "xylitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646447", "map_id": "none", "name": "DCXR tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21929", "map_id": "Q21929", "name": "dhs-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000984", "map_id": "WBGene00000984", "name": "dhs-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646471", "map_id": "none", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661281", "map_id": "CHEBI:17140", "name": "D-xylulose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646105", "map_id": "none", "name": "SORD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21702", "map_id": "Q21702", "name": "SORD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011003", "map_id": "WBGene00011003", "name": "SORD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646468", "map_id": "none", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10646465", "map_id": "P30646", "name": "XYLB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011147", "map_id": "WBGene00011147", "name": "XYLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637289", "map_id": "none", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10637270", "map_id": "none", "name": "Collagen type IV networks with sulfilimine cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10637286", "map_id": "none", "name": "PXDN:Br-", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:15858", "map_id": "CHEBI:15858", "name": "CHEBI:15858", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630811", "map_id": "none", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10630807", "map_id": "none", "name": "Tropocollagen type XXVII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10630809", "map_id": "none", "name": "Collagen type XXVII fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10636388", "map_id": "none", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636386", "map_id": "none", "name": "Collagen type XXVII fibre", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10636390", "map_id": "none", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631426", "map_id": "none", "name": "Tropocollagen alpha-3(IV).alpha-4(IV).alpha-5(IV)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10648222", "map_id": "none", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10598736", "map_id": "Q23621", "name": "gdh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00014095", "map_id": "WBGene00014095", "name": "gdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648212", "map_id": "Q23621", "name": "phospho-gdh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5688274", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10648219", "map_id": "none", "name": "SIRT4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20480", "map_id": "Q20480", "name": "sir-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004801", "map_id": "WBGene00004801", "name": "sir-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601562", "map_id": "none", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72617", "map_id": "none", "name": "eIF1", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601244", "map_id": "Q22918", "name": "EIF5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016496", "map_id": "WBGene00016496", "name": "EIF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601197", "map_id": "none", "name": "EIF2S1:EIF2S2:EIF2S3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601180", "map_id": "Q9TXU7", "name": "eif-1.a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601239", "map_id": "none", "name": "48S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601250", "map_id": "none", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10666329", "map_id": "none", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_9677362", "map_id": "LigandDisplayForward?ligandId=5239", "name": "APAP", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9753466", "map_id": "CHEBI:173517", "name": "NAPQI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9753674", "map_id": "pubchem.compound:3767", "name": "isoniazid", "type": "catalyst", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10666306", "map_id": "none", "name": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9748947", "map_id": "CHEBI:180688", "name": "6TGTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621339", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10666331", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753680", "map_id": "CHEBI:180460", "name": "APAP-CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9753653", "map_id": "CHEBI:133067", "name": "APAP-Cys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10666335", "map_id": "none", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753926", "map_id": "CHEBI:78236", "name": "NAC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9717939", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10666327", "map_id": "none", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753629", "map_id": "none", "name": "APAP-Cys,APAP-Mer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:133438", "map_id": "CHEBI:133438", "name": "CHEBI:133438", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9753624", "map_id": "none", "name": "APAP-Cys,APAP-Mer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:133066", "map_id": "CHEBI:133066", "name": "CHEBI:133066", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:133435", "map_id": "CHEBI:133435", "name": "CHEBI:133435", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666324", "map_id": "none", "name": "ABCC1,4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U2G5", "map_id": "Q9U2G5", "name": "mrp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE72", "map_id": "G5EE72", "name": "mrp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636049", "map_id": "none", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161525", "map_id": "LigandDisplayForward?ligandId=11152", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2161185", "map_id": "LigandDisplayForward?ligandId=11152", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636046", "map_id": "none", "name": "SLC22A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666268", "map_id": "none", "name": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9749786", "map_id": "none", "name": "ASA-, ST", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9749576", "map_id": "none", "name": "ASA-, ST (hepatocyte)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624115", "map_id": "none", "name": "Homologues of SLC22A7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666317", "map_id": "none", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608242", "map_id": "none", "name": "GSTP1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666295", "map_id": "none", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9750557", "map_id": "none", "name": "ABCC5 TPMP substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9748992", "map_id": "CHEBI:180684", "name": "6TIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9748970", "map_id": "CHEBI:180686", "name": "6TGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748959", "map_id": "CHEBI:180685", "name": "6TXMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "pubchem.compound:3037883", "map_id": "pubchem.compound:3037883", "name": "pubchem.compound:3037883", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9750602", "map_id": "none", "name": "ABCC5 TPMP substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:80613", "map_id": "CHEBI:80613", "name": "CHEBI:80613", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:80612", "map_id": "CHEBI:80612", "name": "CHEBI:80612", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2332", "map_id": "CHEBI:2332", "name": "CHEBI:2332", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666333", "map_id": "none", "name": "GGT dimers hydrolyse APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10666285", "map_id": "none", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9750011", "map_id": "CHEBI:36654", "name": "2,3-DHBA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10666314", "map_id": "none", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753559", "map_id": "none", "name": "APAP-GlcA, APAP-SO3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_158604", "map_id": "CHEBI:132962", "name": "APAP-GlcA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9753562", "map_id": "none", "name": "APAP-GlcA, APAP-SO3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:32636", "map_id": "CHEBI:32636", "name": "CHEBI:32636", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630656", "map_id": "none", "name": "Homologues of ABCC2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFP3", "map_id": "G5EFP3", "name": "mrp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003410", "map_id": "WBGene00003410", "name": "mrp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW61", "map_id": "Q9XW61", "name": "mrp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003414", "map_id": "WBGene00003414", "name": "mrp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19048", "map_id": "Q19048", "name": "mrp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003409", "map_id": "WBGene00003409", "name": "mrp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666252", "map_id": "none", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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"type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666322", "map_id": "none", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666319", "map_id": "none", "name": "ABCC3, ABCC4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q3S1M2", "map_id": "Q3S1M2", "name": "mrp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666236", "map_id": "none", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602152", "map_id": "none", "name": "HPRT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NF11", "map_id": "Q9NF11", "name": "hprt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013690", "map_id": "WBGene00013690", "name": "hprt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666281", "map_id": "none", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9749582", "map_id": "CHEBI:13719", "name": "ASA- (GI cell)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749588", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749593", "map_id": "CHEBI:30762", "name": "ST (GI cell)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10648942", "map_id": "none", "name": "Homologues of CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q4LDP0", "map_id": "Q4LDP0", "name": "cest-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020891", "map_id": "WBGene00020891", "name": "cest-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23268", "map_id": "Q23268", "name": "cest-2.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013873", "map_id": "WBGene00013873", "name": "cest-2.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01302", "map_id": "O01302", "name": "cest-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011362", "map_id": "WBGene00011362", "name": "cest-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22008", "map_id": "Q22008", "name": "cest-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020125", "map_id": "WBGene00020125", "name": "cest-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92016", "map_id": "P92016", "name": "cest-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011364", "map_id": "WBGene00011364", "name": "cest-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0K7", "map_id": "H2L0K7", "name": "cest-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020330", "map_id": "WBGene00020330", "name": "cest-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW75", "map_id": "Q9XW75", "name": "cest-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013540", "map_id": "WBGene00013540", "name": "cest-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ23", "map_id": "Q8MQ23", "name": "cest-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010116", "map_id": "WBGene00010116", "name": "cest-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDJ7", "map_id": "G5EDJ7", "name": "cest-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013875", "map_id": "WBGene00013875", "name": "cest-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q04457", "map_id": "Q04457", "name": "ges-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001578", "map_id": "WBGene00001578", "name": "ges-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2Y9", "map_id": "H9G2Y9", "name": "cest-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013874", "map_id": "WBGene00013874", "name": "cest-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21266", "map_id": "Q21266", "name": "cest-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019477", "map_id": "WBGene00019477", "name": "cest-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666304", "map_id": "none", "name": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10666292", "map_id": "none", "name": "ABCC4 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9750587", "map_id": "none", "name": "ABCC4 TPMP substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9750548", "map_id": "none", "name": "ABCC4 TPMP substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10630658", "map_id": "Q19625", "name": "mrp-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10666287", "map_id": "none", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9749985", "map_id": "CHEBI:90176", "name": "2,5-DHB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9750005", "map_id": "CHEBI:88742", "name": "gentisuric acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10666245", "map_id": "none", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10666242", "map_id": "none", "name": "GMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09580", "map_id": "Q09580", "name": "gmps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010912", "map_id": "WBGene00010912", "name": "gmps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666247", "map_id": "none", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9749031", "map_id": "CHEBI:180689", "name": "6TdGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601866", "map_id": "P91425", "name": "guk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020190", "map_id": "WBGene00020190", "name": "guk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666255", "map_id": "none", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9748994", "map_id": "LigandDisplayForward?ligandId=7120", "name": "AZA", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748975", "map_id": "CHEBI:180931", "name": "GS-nitroimidazole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608198", "map_id": "none", "name": "GSTA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666278", "map_id": "none", "name": "BCHE hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9749598", "map_id": "CHEBI:13719", "name": "ASA-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9749546", "map_id": "CHEBI:30762", "name": "ST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10666275", "map_id": "Q9U295", "name": "ace-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00000037", "map_id": "WBGene00000037", "name": "ace-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666273", "map_id": "none", "name": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10666270", "map_id": "Q20538", "name": "Q20538", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10666311", "map_id": "none", "name": "SULT dimers sulfate APAP to APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753448", "map_id": "CHEBI:32635", "name": "APAP-SO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10666308", "map_id": "none", "name": "SULT dimers (APAP)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10666283", "map_id": "none", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9749795", "map_id": "CHEBI:13719", "name": "ASA- (hepatocyte)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10648944", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10666300", "map_id": "none", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9750692", "map_id": "none", "name": "salicylate metabolites", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:176976", "map_id": "CHEBI:176976", "name": "CHEBI:176976", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:176960", "map_id": "CHEBI:176960", "name": "CHEBI:176960", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9750678", "map_id": "none", "name": "salicylate metabolites", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10666297", "map_id": "none", "name": "ABCC2, ABCC3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636044", "map_id": "none", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161194", "map_id": "pubchem.compound:469588", "name": "abacavir monophosphate", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161175", "map_id": "CHEBI:34660", "name": "cyclopropylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636039", "map_id": "none", "name": "ADAL:Zn", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IG39", "map_id": "Q8IG39", "name": "adal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016632", "map_id": "WBGene00016632", "name": "adal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666238", "map_id": "none", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10661697", "map_id": "none", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648618", "map_id": "Q93725", "name": "ned-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10661684", "map_id": "none", "name": "UBA3:NAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18217", "map_id": "Q18217", "name": "ula-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006735", "map_id": "WBGene00006735", "name": "ula-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19360", "map_id": "Q19360", "name": "rfl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004341", "map_id": "WBGene00004341", "name": "rfl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10661694", "map_id": "none", "name": "NEDD8-UBA3:NAE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601554", "map_id": "none", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601535", "map_id": "none", "name": "80S ribosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601108", "map_id": "none", "name": "40S ribosomal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626992", "map_id": "none", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981617", "map_id": "none", "name": "Glycoprotein with GlcNAc in position 5", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10626989", "map_id": "Q9NDH7", "name": "gly-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001627", "map_id": "WBGene00001627", "name": "gly-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661677", "map_id": "none", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648609", "map_id": "none", "name": "UCHL3,SENP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657880", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628541", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853396", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "CHEBI:91284", "map_id": "CHEBI:91284", "name": "CHEBI:91284", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657877", "map_id": "Q8TA65", "name": "eng-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017164", "map_id": "WBGene00017164", "name": "eng-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606457", "map_id": "none", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855666", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10606454", "map_id": "D6RYD7", "name": "pigw-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022447", "map_id": "WBGene00022447", "name": "pigw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10662783", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628861", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10662772", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17390", "map_id": "Q17390", "name": "cul-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000837", "map_id": "WBGene00000837", "name": "cul-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP60", "map_id": "Q7JP60", "name": "CCDC22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019959", "map_id": "WBGene00019959", "name": "CCDC22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AQR5", "map_id": "A0A0K3AQR5", "name": "COMMD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "T28F2.2b", "map_id": "T28F2.2b", "name": "COMMD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3C8", "map_id": "Q9U3C8", "name": "dcn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010428", "map_id": "WBGene00010428", "name": "dcn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662776", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10662781", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601258", "map_id": "none", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627051", "map_id": "none", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981618", "map_id": "none", "name": "Glycoprotein with galactose", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10627048", "map_id": "none", "name": "B4GALT1-6 homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10659540", "map_id": "none", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131164", "map_id": "CHEBI:48861", "name": "geranylgeranyl diphosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10659531", "map_id": "none", "name": "RABGGTA:RABGGTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659538", "map_id": "none", "name": "RABGGTA:RABGGTB:CHMs:GGPP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622073", "map_id": "none", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449649", "map_id": "CHEBI:59081", "name": "(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_532542", "map_id": "CHEBI:15812", "name": "DbGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449311", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449638", "map_id": "CHEBI:53020", "name": "(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622070", "map_id": "P52887", "name": "algn-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007464", "map_id": "WBGene00007464", "name": "algn-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606473", "map_id": "none", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_display": "none" }, { "id": "Q22071", "map_id": "Q22071", "name": "mec-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003177", "map_id": "WBGene00003177", "name": "mec-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGS4", "map_id": "G5EGS4", "name": "kel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002184", "map_id": "WBGene00002184", "name": "kel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17583", "map_id": "Q17583", "name": "mlt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007252", "map_id": "WBGene00007252", "name": "mlt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34284", "map_id": "P34284", "name": "fbxl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015350", "map_id": "WBGene00015350", "name": "fbxl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34569", "map_id": "P34569", "name": "kel-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002186", "map_id": "WBGene00002186", "name": "kel-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EES6", "map_id": "G5EES6", "name": "ufd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007333", "map_id": "WBGene00007333", "name": "ufd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93349", "map_id": "Q93349", "name": "swah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007985", "map_id": "WBGene00007985", "name": "swah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21209", "map_id": "Q21209", "name": "brd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000265", "map_id": "WBGene00000265", "name": "brd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3G1", "map_id": "Q9N3G1", "name": "FBXL14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021815", "map_id": "WBGene00021815", "name": "FBXL14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL53", "map_id": "Q9BL53", "name": "tub-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022139", "map_id": "WBGene00022139", "name": "tub-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23639", "map_id": "Q23639", "name": "cul-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662736", "map_id": "none", "name": "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658432", "map_id": "none", "name": "COP9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622134", "map_id": "none", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449222", "map_id": "CHEBI:18278", "name": "GlcNAcDOLDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449293", "map_id": "CHEBI:18341", "name": "N,N'-DCDOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622131", "map_id": "none", "name": "ALG13:ALG14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "U4PE03", "map_id": "U4PE03", "name": "algn-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019725", "map_id": "WBGene00019725", "name": "algn-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92012", "map_id": "P92012", "name": "algn-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011193", "map_id": "WBGene00011193", "name": "algn-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665016", "map_id": "none", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10665014", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "V6CM12", "map_id": "V6CM12", "name": "spp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004992", "map_id": "WBGene00004992", "name": "spp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17387", "map_id": "O17387", "name": "spp-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004998", "map_id": "WBGene00004998", "name": "spp-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18279", "map_id": "Q18279", "name": "spp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004993", "map_id": "WBGene00004993", "name": "spp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647827", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10622160", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449365", "map_id": "CHEBI:59091", "name": "(GlcNAc)2 (Man)8 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449371", "map_id": "CHEBI:37637", "name": "(GlcNAc)2 (Man)9 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10657617", "map_id": "none", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1022114", "map_id": "none", "name": "unfolded protein", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8852852", "map_id": "none", "name": "(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10657614", "map_id": "none", "name": "Deglycosylation complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P90859", "map_id": "P90859", "name": "hrdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009164", "map_id": "WBGene00009164", "name": "hrdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TW67", "map_id": "Q9TW67", "name": "png-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010160", "map_id": "WBGene00010160", "name": "png-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXH9", "map_id": "Q9TXH9", "name": "ubxn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017733", "map_id": "WBGene00017733", "name": "ubxn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93561", "map_id": "Q93561", "name": "cup-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000843", "map_id": "WBGene00000843", "name": "cup-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659527", "map_id": "none", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659523", "map_id": "P41992", "name": "ggtb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10659521", "map_id": "G5EG43", "name": "PRL-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004184", "map_id": "WBGene00004184", "name": "PRL-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659525", "map_id": "none", "name": "FarC-PTP4A2:RABGGTB", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EG43", "map_id": "G5EG43", "name": "PRL-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622089", "map_id": "none", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10622086", "map_id": "Q23361", "name": "algn-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022629", "map_id": "WBGene00022629", "name": "algn-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647344", "map_id": "none", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676932", "map_id": "CHEBI:49032", "name": "L-methionine (R)-S-oxide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647341", "map_id": "none", "name": "MSRBs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34436", "map_id": "P34436", "name": "MSRB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018419", "map_id": "WBGene00018419", "name": "MSRB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622168", "map_id": "none", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449283", "map_id": "CHEBI:18396", "name": "MDCDD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622165", "map_id": "Q22797", "name": "algn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020820", "map_id": "WBGene00020820", "name": "algn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647352", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647349", "map_id": "Q27873", "name": "pcm-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003954", "map_id": "WBGene00003954", "name": "pcm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10654760", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10654738", "map_id": "none", "name": "ETF1 dimer:eRF3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10654745", "map_id": "none", "name": "Me-Q185-ETF1 dimer:eRF3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10647679", "map_id": "none", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647675", "map_id": "Q17525", "name": "tes-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00015217", "map_id": "WBGene00015217", "name": "tes-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647670", "map_id": "none", "name": "Homologues of GATA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q10655", "map_id": "Q10655", "name": "elt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001250", "map_id": "WBGene00001250", "name": "elt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGN3", "map_id": "G5EGN3", "name": "elt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001253", "map_id": "WBGene00001253", "name": "elt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PMB4", "map_id": "U4PMB4", "name": "egl-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001186", "map_id": "WBGene00001186", "name": "egl-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647677", "map_id": "none", "name": "LMCD1:GATA6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17525", "map_id": "Q17525", "name": "tes-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626198", "map_id": "none", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10626195", "map_id": "Q11068", "name": "gly-13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "WBGene00001638", "map_id": "WBGene00001638", "name": "gly-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648804", "map_id": "none", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691496", "map_id": "none", "name": "NAc-Ser:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5691517", "map_id": "CHEBI:83690", "name": "NAc-Ser residue", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785226", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648801", "map_id": "Q9TYX1", "name": "dpf-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606465", "map_id": "none", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855659", "map_id": "CHEBI:53056", "name": "mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855663", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10606462", "map_id": "G4SNP0", "name": "pign-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021840", "map_id": "WBGene00021840", "name": "pign-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601558", "map_id": "none", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601175", "map_id": "none", "name": "eIF3 subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601556", "map_id": "none", "name": "40S:eIF3:eIF1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601550", "map_id": "none", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601544", "map_id": "none", "name": "80S:Met-tRNAi:mRNA:eIF5B:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGT7", "map_id": "G5EGT7", "name": "iffb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021857", "map_id": "WBGene00021857", "name": "iffb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601548", "map_id": "none", "name": "80S:Met-tRNAi:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601546", "map_id": "none", "name": "eIF5B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606481", "map_id": "none", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10606478", "map_id": "D4YWC2", "name": "pigl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013131", "map_id": "WBGene00013131", "name": "pigl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614701", "map_id": "none", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614687", "map_id": "Q20678", "name": "sec-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614677", "map_id": "Q18286", "name": "sec-15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614697", "map_id": "P91149", "name": "exoc-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614672", "map_id": "Q18406", "name": "sec-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614692", "map_id": "Q19262", "name": "sec-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "species_10614682", "map_id": "Q95Q35", "name": "exoc-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614667", "map_id": "Q22706", "name": "sec-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614662", "map_id": "Q9XWS2", "name": "sec-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10614699", "map_id": "none", "name": "Exocyst Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658789", "map_id": "none", "name": "TTLLs polyglutamylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658759", "map_id": "none", "name": "Polyglutamylated microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658786", "map_id": "none", "name": "TTLLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q564U4", "map_id": "Q564U4", "name": "ttll-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044187", "map_id": "WBGene00044187", "name": "ttll-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZM9", "map_id": "H2KZM9", "name": "ttll-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019230", "map_id": "WBGene00019230", "name": "ttll-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09512", "map_id": "Q09512", "name": "ttll-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008405", "map_id": "WBGene00008405", "name": "ttll-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09647", "map_id": "Q09647", "name": "ttll-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014232", "map_id": "WBGene00014232", "name": "ttll-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E9P886", "map_id": "E9P886", "name": "ttll-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008331", "map_id": "WBGene00008331", "name": "ttll-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620021", "map_id": "none", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620018", "map_id": "Q23530", "name": "SLC34A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00022767", "map_id": "WBGene00022767", "name": "SLC34A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622109", "map_id": "none", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10622106", "map_id": "Q09226", "name": "algn-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007435", "map_id": "WBGene00007435", "name": "algn-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659795", "map_id": "none", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659631", "map_id": "none", "name": "RGGT:CHMs:RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17788", "map_id": "O17788", "name": "GGC-RAB2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008672", "map_id": "WBGene00008672", "name": "GGC-RAB2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18969", "map_id": "Q18969", "name": "rab-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004286", "map_id": "WBGene00004286", "name": "rab-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBF0", "map_id": "G5EBF0", "name": "glo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011083", "map_id": "WBGene00011083", "name": "glo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFA6", "map_id": "G5EFA6", "name": "rab-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004285", "map_id": "WBGene00004285", "name": "rab-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1W9", "map_id": "Q9U1W9", "name": "rab-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004278", "map_id": "WBGene00004278", "name": "rab-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18773", "map_id": "Q18773", "name": "GGC-RAB41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016874", "map_id": "WBGene00016874", "name": "GGC-RAB41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20365", "map_id": "Q20365", "name": "rab-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004283", "map_id": "WBGene00004283", "name": "rab-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17789", "map_id": "O17789", "name": "GGC-RAB2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2C3", "map_id": "Q9U2C3", "name": "rab-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004284", "map_id": "WBGene00004284", "name": "rab-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22045", "map_id": "Q22045", "name": "rab-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004279", "map_id": "WBGene00004279", "name": "rab-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWZ3", "map_id": "Q9XWZ3", "name": "rab-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004282", "map_id": "WBGene00004282", "name": "rab-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659790", "map_id": "none", "name": "CHMs:GGC-RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659792", "map_id": "none", "name": "RGGTA:RGGTB:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662768", "map_id": "none", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662761", "map_id": "none", "name": "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21934", "map_id": "Q21934", "name": "DCAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011242", "map_id": "WBGene00011242", "name": "DCAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22059", "map_id": "Q22059", "name": "cdt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011318", "map_id": "WBGene00011318", "name": "cdt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W5Q8", "map_id": "Q4W5Q8", "name": "adpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044440", "map_id": "WBGene00044440", "name": "adpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90794", "map_id": "P90794", "name": "wdr-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008419", "map_id": "WBGene00008419", "name": "wdr-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93759", "map_id": "Q93759", "name": "swan-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009976", "map_id": "WBGene00009976", "name": "swan-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09392", "map_id": "Q09392", "name": "DCAF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018564", "map_id": "WBGene00018564", "name": "DCAF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10662763", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10662765", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622081", "map_id": "none", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10622078", "map_id": "Q9U1Z2", "name": "algn-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013362", "map_id": "WBGene00013362", "name": "algn-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647620", "map_id": "none", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane" }, { "id": "species_5684863", "map_id": "none", "name": "PC, PG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_194276", "map_id": "CHEBI:16110", "name": "phosphatidylcholines", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5684869", "map_id": "none", "name": "PC, PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "species_10647617", "map_id": "Q1RS86", "name": "abt-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane", "complex": "false" }, { "id": "reaction_10650582", "map_id": "none", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10647837", "map_id": "none", "name": "Homologues of SFTPB(201-279)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10647960", "map_id": "none", "name": "SFTPB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10628543", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628539", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "reaction_10662774", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662770", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628807", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601260", "map_id": "none", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72393", "map_id": "none", "name": "Met-tRNAi", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601201", "map_id": "none", "name": "ternary complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633480", "map_id": "none", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633474", "map_id": "none", "name": "Signal Recognition Particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91240", "map_id": "P91240", "name": "srpa-72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017245", "map_id": "WBGene00017245", "name": "srpa-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20822", "map_id": "Q20822", "name": "srpa-68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010097", "map_id": "WBGene00010097", "name": "srpa-68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE80", "map_id": "G5EE80", "name": "SRP54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009012", "map_id": "WBGene00009012", "name": "SRP54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34642", "map_id": "P34642", "name": "SRP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013984", "map_id": "WBGene00013984", "name": "SRP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61749", "map_id": "O61749", "name": "SRP19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018159", "map_id": "WBGene00018159", "name": "SRP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10633476", "map_id": "none", "name": "ribosome:mRNA:polypeptide+signal", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10633478", "map_id": "none", "name": "SRP:polypeptide+signal:ribosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601560", "map_id": "none", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601203", "map_id": "none", "name": "43S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622142", "map_id": "none", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449737", "map_id": "CHEBI:59085", "name": "(GlcNAc)2 (Man)2 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622139", "map_id": "Q19265", "name": "algn-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00017282", "map_id": "WBGene00017282", "name": "algn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601252", "map_id": "none", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601221", "map_id": "none", "name": "eIF4A subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601233", "map_id": "none", "name": "eIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659633", "map_id": "none", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659629", "map_id": "none", "name": "RABs:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662660", "map_id": "none", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10662451", "map_id": "none", "name": "RBX1:CUL4:DDB1:DCAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10662656", "map_id": "G5ED41", "name": "cand-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10662658", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606489", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10606486", "map_id": "O02164", "name": "pigv-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020375", "map_id": "WBGene00020375", "name": "pigv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10661701", "map_id": "none", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10661699", "map_id": "none", "name": "NEDD8-UBA3:NAE1:NEDD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622064", "map_id": "none", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449298", "map_id": "CHEBI:53022", "name": "(GlcNAc)2 (Man)5 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622056", "map_id": "E5QCI3", "name": "algn-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010720", "map_id": "WBGene00010720", "name": "algn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647958", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10647847", "map_id": "none", "name": "Homologues of SFTPB(25-200)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10647857", "map_id": "none", "name": "Homologues of SFTPB(280-381)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10647955", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "Q7JKL9", "map_id": "Q7JKL9", "name": "asp-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013973", "map_id": "WBGene00013973", "name": "asp-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01531", "map_id": "O01531", "name": "asp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017678", "map_id": "WBGene00017678", "name": "asp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55956", "map_id": "P55956", "name": "asp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000216", "map_id": "WBGene00000216", "name": "asp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45072", "map_id": "O45072", "name": "asp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015700", "map_id": "WBGene00015700", "name": "asp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18020", "map_id": "Q18020", "name": "hrg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007605", "map_id": "WBGene00007605", "name": "hrg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NE0", "map_id": "Q86NE0", "name": "asp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000215", "map_id": "WBGene00000215", "name": "asp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN5", "map_id": "Q8MYN5", "name": "asp-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012683", "map_id": "WBGene00012683", "name": "asp-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN6", "map_id": "Q8MYN6", "name": "asp-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012682", "map_id": "WBGene00012682", "name": "asp-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01532", "map_id": "O01532", "name": "asp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000218", "map_id": "WBGene00000218", "name": "asp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN7", "map_id": "Q8MYN7", "name": "asp-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012681", "map_id": "WBGene00012681", "name": "asp-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22972", "map_id": "Q22972", "name": "asp-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017881", "map_id": "WBGene00017881", "name": "asp-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01530", "map_id": "O01530", "name": "asp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000219", "map_id": "WBGene00000219", "name": "asp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC01", "map_id": "G5EC01", "name": "asp-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077655", "map_id": "WBGene00077655", "name": "asp-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEI4", "map_id": "G5EEI4", "name": "asp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000214", "map_id": "WBGene00000214", "name": "asp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605938", "map_id": "none", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605936", "map_id": "none", "name": "eEF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662654", "map_id": "none", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662650", "map_id": "none", "name": "CRL E3 ubiquitin ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648772", "map_id": "G5ED41", "name": "cand-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10662652", "map_id": "none", "name": "CRL E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601552", "map_id": "none", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601246", "map_id": "none", "name": "40S:Met-tRNAi:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601542", "map_id": "none", "name": "eIF5B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625280", "map_id": "none", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10623945", "map_id": "G5ED07", "name": "pdi-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00003964", "map_id": "WBGene00003964", "name": "pdi-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625276", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "P34652", "map_id": "P34652", "name": "cnx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000567", "map_id": "WBGene00000567", "name": "cnx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27798", "map_id": "P27798", "name": "crt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000802", "map_id": "WBGene00000802", "name": "crt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625278", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "G5ED07", "map_id": "G5ED07", "name": "pdi-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659533", "map_id": "none", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659529", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10630959", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630941", "map_id": "none", "name": "LPEAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10661834", "map_id": "none", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2173763", "map_id": "CHEBI:60479", "name": "lysoPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8952253", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8954142", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10661831", "map_id": "Q21515", "name": "PLA2G15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00010872", "map_id": "WBGene00010872", "name": "LCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660478", "map_id": "none", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8878649", "map_id": "CHEBI:62833", "name": "MYS-LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8934414", "map_id": "CHEBI:75562", "name": "1-MMG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10660475", "map_id": "Q19460", "name": "acp-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00008801", "map_id": "WBGene00008801", "name": "acp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631941", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10631070", "map_id": "none", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426955", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10631067", "map_id": "none", "name": "CDIPT:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9U2G1", "map_id": "Q9U2G1", "name": "pisy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012897", "map_id": "WBGene00012897", "name": "pisy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631934", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602375", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602372", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10631217", "map_id": "none", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10631155", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q965T2", "map_id": "Q965T2", "name": "PITPNB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021854", "map_id": "WBGene00021854", "name": "PITPNB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10631215", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10631939", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602390", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10631075", "map_id": "none", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75973", "map_id": "CHEBI:17197", "name": "GO3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10631072", "map_id": "G5EFP8", "name": "acl-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00012911", "map_id": "WBGene00012911", "name": "acl-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630911", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10630908", "map_id": "Q95R12", "name": "acl-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00017888", "map_id": "WBGene00017888", "name": "acl-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630922", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630916", "map_id": "Q19468", "name": "mboa-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00008806", "map_id": "WBGene00008806", "name": "mboa-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623952", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10603021", "map_id": "none", "name": "Homologues of AGPAT6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EE59", "map_id": "G5EE59", "name": "AGPAT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010902", "map_id": "WBGene00010902", "name": "AGPAT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5S8", "map_id": "Q9N5S8", "name": "acl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018657", "map_id": "WBGene00018657", "name": "acl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21812", "map_id": "Q21812", "name": "acl-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011106", "map_id": "WBGene00011106", "name": "acl-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631123", "map_id": "none", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524067", "map_id": "CHEBI:60377", "name": "cytidine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603078", "map_id": "none", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603075", "map_id": "none", "name": "GPD1/GPD1L homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34517", "map_id": "P34517", "name": "gpdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010778", "map_id": "WBGene00010778", "name": "gpdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTS4", "map_id": "Q9XTS4", "name": "gpdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009824", "map_id": "WBGene00009824", "name": "gpdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660215", "map_id": "none", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10660211", "map_id": "Q17764", "name": "STARD7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00007386", "map_id": "WBGene00007386", "name": "STARD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660213", "map_id": "none", "name": "STARD7:PC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q17764", "map_id": "Q17764", "name": "STARD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631235", "map_id": "none", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10631219", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10631153", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10630997", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630994", "map_id": "Q8MXR3", "name": "ipla-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022233", "map_id": "WBGene00022233", "name": "ipla-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630967", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10630944", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10631007", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10630887", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10630884", "map_id": "none", "name": "LPCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10630919", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10649397", "map_id": "none", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694568", "map_id": "CHEBI:61232", "name": "NAPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694580", "map_id": "CHEBI:52571", "name": "GPAEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694567", "map_id": "CHEBI:22221", "name": "acyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10649394", "map_id": "O02218", "name": "lid-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007711", "map_id": "WBGene00007711", "name": "lid-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631146", "map_id": "none", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10631143", "map_id": "none", "name": "PCYT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8IU09", "map_id": "Q8IU09", "name": "PCYT1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021215", "map_id": "WBGene00021215", "name": "PCYT1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49583", "map_id": "P49583", "name": "PCYT1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017241", "map_id": "WBGene00017241", "name": "PCYT1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649433", "map_id": "none", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_5696069", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696066", "map_id": "none", "name": "MAG,DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_5696026", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696037", "map_id": "none", "name": "LPA,PA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_10649430", "map_id": "none", "name": "AGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q10123", "map_id": "Q10123", "name": "AGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018674", "map_id": "WBGene00018674", "name": "AGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631014", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10659846", "map_id": "none", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659841", "map_id": "O18155", "name": "STARD10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012127", "map_id": "WBGene00012127", "name": "phospho-p-S284-STARD10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659844", "map_id": "O18155", "name": "phospho-p-S284-STARD10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10631167", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10631164", "map_id": "none", "name": "CDS1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P53439", "map_id": "P53439", "name": "cdgs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10609637", "map_id": "none", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_188458", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_188451", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10609634", "map_id": "P90795", "name": "gpdh-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00012031", "map_id": "WBGene00012031", "name": "gpdh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649368", "map_id": "none", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694502", "map_id": "CHEBI:64483", "name": "LPC(14:0)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5694457", "map_id": "CHEBI:11230", "name": "1AGPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10649365", "map_id": "none", "name": "Homologues of ABHD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U1Z6", "map_id": "Q9U1Z6", "name": "abhd-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013358", "map_id": "WBGene00013358", "name": "abhd-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18610", "map_id": "Q18610", "name": "abhd-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016644", "map_id": "WBGene00016644", "name": "abhd-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631157", "map_id": "none", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10631041", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10631038", "map_id": "none", "name": "CEPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10631060", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524057", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10631057", "map_id": "none", "name": "CHPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10631190", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10631187", "map_id": "O18143", "name": "pssy-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00012095", "map_id": "WBGene00012095", "name": "pssy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631120", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10631117", "map_id": "none", "name": "CHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10631016", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10630906", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10631182", "map_id": "none", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10631177", "map_id": "G5EDU3", "name": "pld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10631937", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10603033", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10603030", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q95R12", "map_id": "Q95R12", "name": "acl-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22267", "map_id": "Q22267", "name": "acl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011543", "map_id": "WBGene00011543", "name": "acl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16526", "map_id": "O16526", "name": "acl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631932", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602420", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615365", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615360", "map_id": "none", "name": "Cholinesterase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U295", "map_id": "Q9U295", "name": "ace-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615363", "map_id": "none", "name": "ACHE:ACHEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=8994", "map_id": "LigandDisplayForward?ligandId=8994", "name": "LigandDisplayForward?ligandId=8994", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8993", "map_id": "LigandDisplayForward?ligandId=8993", "name": "LigandDisplayForward?ligandId=8993", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6602", "map_id": "LigandDisplayForward?ligandId=6602", "name": "LigandDisplayForward?ligandId=6602", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6599", "map_id": "LigandDisplayForward?ligandId=6599", "name": "LigandDisplayForward?ligandId=6599", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6687", "map_id": "LigandDisplayForward?ligandId=6687", "name": "LigandDisplayForward?ligandId=6687", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6598", "map_id": "LigandDisplayForward?ligandId=6598", "name": "LigandDisplayForward?ligandId=6598", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6693", "map_id": "LigandDisplayForward?ligandId=6693", "name": "LigandDisplayForward?ligandId=6693", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7597", "map_id": "LigandDisplayForward?ligandId=7597", "name": "LigandDisplayForward?ligandId=7597", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9073", "map_id": "LigandDisplayForward?ligandId=9073", "name": "LigandDisplayForward?ligandId=9073", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9074", "map_id": "LigandDisplayForward?ligandId=9074", "name": "LigandDisplayForward?ligandId=9074", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659441", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10659438", "map_id": "none", "name": "PITPNM1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEM9", "map_id": "G5EEM9", "name": "ipla-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019747", "map_id": "WBGene00019747", "name": "ipla-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EED9", "map_id": "G5EED9", "name": "pitp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010813", "map_id": "WBGene00010813", "name": "pitp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659911", "map_id": "none", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8874447", "map_id": "none", "name": "PMCHO, PMETAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:17810", "map_id": "CHEBI:17810", "name": "CHEBI:17810", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17476", "map_id": "CHEBI:17476", "name": "CHEBI:17476", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8874450", "map_id": "none", "name": "GPCHO, GPETAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:36314", "map_id": "CHEBI:36314", "name": "CHEBI:36314", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36313", "map_id": "CHEBI:36313", "name": "CHEBI:36313", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659908", "map_id": "Q21552", "name": "TMEM86B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010943", "map_id": "WBGene00010943", "name": "TMEM86B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602878", "map_id": "none", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602869", "map_id": "O44199", "name": "rad-50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602874", "map_id": "Q23255", "name": "mre-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602876", "map_id": "none", "name": "RAD50:MRE11A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664492", "map_id": "none", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664474", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54815", "map_id": "P54815", "name": "mspn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010557", "map_id": "WBGene00010557", "name": "mspn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91262", "map_id": "P91262", "name": "pxmp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017574", "map_id": "WBGene00017574", "name": "pxmp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6AHP8", "map_id": "Q6AHP8", "name": "fis-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001425", "map_id": "WBGene00001425", "name": "fis-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617465", "map_id": "P34453", "name": "prx-19", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004201", "map_id": "WBGene00004201", "name": "prx-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664476", "map_id": "none", "name": "PEX19:class I PMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34453", "map_id": "P34453", "name": "prx-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664490", "map_id": "none", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10617443", "map_id": "Q18028", "name": "prx-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00004193", "map_id": "WBGene00004193", "name": "prx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664478", "map_id": "none", "name": "PEX3:PEX19:class I PMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q18028", "map_id": "Q18028", "name": "prx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664488", "map_id": "none", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10664486", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10657346", "map_id": "none", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10657343", "map_id": "Q11186", "name": "atgl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10657341", "map_id": "none", "name": "PNPLA4 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657338", "map_id": "Q9N5Z7", "name": "PNPLA4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015241", "map_id": "WBGene00015241", "name": "PNPLA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643167", "map_id": "none", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643163", "map_id": "none", "name": "FABPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10643165", "map_id": "none", "name": "FABPs:LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657349", "map_id": "none", "name": "PNPLA4 hydrolyzes retinyl palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664778", "map_id": "none", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664735", "map_id": "none", "name": "SGTA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21746", "map_id": "Q21746", "name": "sgt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019893", "map_id": "WBGene00019893", "name": "sgt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664774", "map_id": "none", "name": "Tail-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19967", "map_id": "Q19967", "name": "sec-61.G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001303", "map_id": "WBGene00001303", "name": "sec-61.G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XS2", "map_id": "Q95XS2", "name": "sec-61.b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021427", "map_id": "WBGene00021427", "name": "sec-61.b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2K5ATR7", "map_id": "A0A2K5ATR7", "name": "ubc-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022450", "map_id": "WBGene00022450", "name": "ubc-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93838", "map_id": "Q93838", "name": "serp-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010337", "map_id": "WBGene00010337", "name": "serp-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664776", "map_id": "none", "name": "Tail-anchored protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664366", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10664361", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10664363", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10664355", "map_id": "none", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10664321", "map_id": "none", "name": "PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10664319", "map_id": "none", "name": "PEX5S,L:Cargo protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20048", "map_id": "Q20048", "name": "mlcd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17761", "map_id": "O17761", "name": "ech-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWV6", "map_id": "Q7YWV6", "name": "MPV17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011826", "map_id": "WBGene00011826", "name": "MPV17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76383", "map_id": "O76383", "name": "hpo-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016061", "map_id": "WBGene00016061", "name": "hpo-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20959", "map_id": "Q20959", "name": "ECH1(1-328)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019022", "map_id": "WBGene00019022", "name": "ECH1(1-328)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01739", "map_id": "O01739", "name": "ddo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017648", "map_id": "WBGene00017648", "name": "ddo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XG9", "map_id": "Q95XG9", "name": "daao-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022076", "map_id": "WBGene00022076", "name": "daao-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19564", "map_id": "Q19564", "name": "ddo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017565", "map_id": "WBGene00017565", "name": "ddo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91148", "map_id": "P91148", "name": "ndx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN1", "map_id": "Q95XN1", "name": "HMGCL(1-325)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022150", "map_id": "WBGene00022150", "name": "HMGCL(1-325)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP2", "map_id": "G5EDP2", "name": "daf-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94055", "map_id": "Q94055", "name": "agxt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011767", "map_id": "WBGene00011767", "name": "agxt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA25", "map_id": "Q9NA25", "name": "ndx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003585", "map_id": "WBGene00003585", "name": "ndx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16249", "map_id": "O16249", "name": "IDE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018426", "map_id": "WBGene00018426", "name": "IDE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45307", "map_id": "O45307", "name": "ddo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008127", "map_id": "WBGene00008127", "name": "ddo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFP8", "map_id": "G5EFP8", "name": "acl-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WVT5", "map_id": "A0A486WVT5", "name": "CROT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18006", "map_id": "Q18006", "name": "PIPOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015783", "map_id": "WBGene00015783", "name": "PIPOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17499", "map_id": "Q17499", "name": "CRAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW87", "map_id": "Q9XW87", "name": "lonp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013541", "map_id": "WBGene00013541", "name": "lonp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18122", "map_id": "Q18122", "name": "AMACR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664323", "map_id": "none", "name": "PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10664353", "map_id": "none", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10664351", "map_id": "none", "name": "Cargo proteins containing PTS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10664944", "map_id": "none", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10664940", "map_id": "none", "name": "Mislocalized membrane protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664942", "map_id": "none", "name": "Mislocalized membrane protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625255", "map_id": "none", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428571", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_917775", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen", "complex": "false" }, { "id": "species_10625216", "map_id": "P34579", "name": "unc-47", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "false" }, { "id": "WBGene00006783", "map_id": "WBGene00006783", "name": "unc-47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625195", "map_id": "none", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625192", "map_id": "none", "name": "PXLP-K405-GAD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "G5EDB7", "map_id": "G5EDB7", "name": "unc-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006762", "map_id": "WBGene00006762", "name": "unc-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625801", "map_id": "none", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917758", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle" }, { "id": "species_10614063", "map_id": "Q22366", "name": "unc-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625246", "map_id": "none", "name": "GABA Loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "P34579", "map_id": "P34579", "name": "unc-47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625248", "map_id": "none", "name": "Docked GABA loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625207", "map_id": "none", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane" }, { "id": "species_10625204", "map_id": "none", "name": "PXLP-GAD dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10607988", "map_id": "none", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607978", "map_id": "Q09649", "name": "phospho-fzr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607968", "map_id": "Q09649", "name": "fzr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607985", "map_id": "none", "name": "phospho-Cdh1 phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P81299", "map_id": "P81299", "name": "cdc-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000383", "map_id": "WBGene00000383", "name": "cdc-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650541", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10650538", "map_id": "none", "name": "keratinocyte LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10657183", "map_id": "none", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10657179", "map_id": "none", "name": "Desmosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10657165", "map_id": "G5ED30", "name": "vab-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00006875", "map_id": "WBGene00006875", "name": "vab-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657181", "map_id": "none", "name": "Desmosome:PERP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ED30", "map_id": "G5ED30", "name": "vab-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664096", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024574", "map_id": "none", "name": "AT-RvD1, AT-RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138179", "map_id": "CHEBI:138179", "name": "CHEBI:138179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138614", "map_id": "CHEBI:138614", "name": "CHEBI:138614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664158", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024873", "map_id": "CHEBI:140225", "name": "16S,17S-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664108", "map_id": "none", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024012", "map_id": "CHEBI:136113", "name": "17(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664098", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024809", "map_id": "none", "name": "RvD3, RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138649", "map_id": "CHEBI:138649", "name": "CHEBI:138649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138648", "map_id": "CHEBI:138648", "name": "CHEBI:138648", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664102", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024759", "map_id": "none", "name": "RvD1, RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:81565", "map_id": "CHEBI:81565", "name": "CHEBI:81565", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:81564", "map_id": "CHEBI:81564", "name": "CHEBI:81564", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664104", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024570", "map_id": "none", "name": "AT-RvD3, AT-RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138616", "map_id": "CHEBI:138616", "name": "CHEBI:138616", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138615", "map_id": "CHEBI:138615", "name": "CHEBI:138615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664100", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024893", "map_id": "CHEBI:140192", "name": "17R(16)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024879", "map_id": "CHEBI:140202", "name": "AT-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664106", "map_id": "none", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024522", "map_id": "CHEBI:138590", "name": "17(R)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648108", "map_id": "none", "name": "Activated ATM phosphorylates ABL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648103", "map_id": "P03949", "name": "abl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10648895", "map_id": "none", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647722", "map_id": "none", "name": "DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648892", "map_id": "none", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648889", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10647734", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647750", "map_id": "none", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647747", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10647707", "map_id": "O17670", "name": "phospho-eya-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001377", "map_id": "WBGene00001377", "name": "eya-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647638", "map_id": "none", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647634", "map_id": "none", "name": "Homologues of p-T68-CHEK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U1Y5", "map_id": "Q9U1Y5", "name": "phospho-chk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000499", "map_id": "WBGene00000499", "name": "phospho-chk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4F324", "map_id": "A4F324", "name": "phospho-p-S,3T-CHEK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011612", "map_id": "WBGene00011612", "name": "phospho-p-S,3T-CHEK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647636", "map_id": "none", "name": "p-T68-CHEK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647737", "map_id": "none", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647698", "map_id": "O17670", "name": "eya-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10648897", "map_id": "none", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647693", "map_id": "none", "name": "p-Y142-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647759", "map_id": "none", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647755", "map_id": "Q9BKZ9", "name": "feh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001410", "map_id": "WBGene00001410", "name": "feh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647757", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9BKZ9", "map_id": "Q9BKZ9", "name": "feh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647653", "map_id": "none", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647650", "map_id": "none", "name": "Homologues of p-S,3T-CHEK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658362", "map_id": "none", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658356", "map_id": "P90761", "name": "unc-41", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006777", "map_id": "WBGene00006777", "name": "unc-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658351", "map_id": "none", "name": "SYT dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91493", "map_id": "P91493", "name": "snt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004924", "map_id": "WBGene00004924", "name": "snt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658360", "map_id": "none", "name": "STON2,1:SYT dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90761", "map_id": "P90761", "name": "unc-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658873", "map_id": "none", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658240", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N489", "map_id": "Q9N489", "name": "ncap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022453", "map_id": "WBGene00022453", "name": "ncap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECQ3", "map_id": "G5ECQ3", "name": "sel-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004762", "map_id": "WBGene00004762", "name": "sel-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20483", "map_id": "Q20483", "name": "gakh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018516", "map_id": "WBGene00018516", "name": "gakh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXS0", "map_id": "Q9TXS0", "name": "fcho-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018974", "map_id": "WBGene00018974", "name": "fcho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658793", "map_id": "none", "name": "ARRB:ARRB-binding GPCRs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658869", "map_id": "none", "name": "ARBBs:ARBB-binding GPCRs:clathrin-coated pit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658871", "map_id": "none", "name": "UBQLN2:UIM-containing proteins", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFF7", "map_id": "G5EFF7", "name": "ubql-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008852", "map_id": "WBGene00008852", "name": "ubql-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90879", "map_id": "P90879", "name": "UBQLN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009878", "map_id": "WBGene00009878", "name": "UBQLN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659086", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659080", "map_id": "Q9XZI6", "name": "unc-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006751", "map_id": "WBGene00006751", "name": "unc-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659078", "map_id": "none", "name": "VAMP2,3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659084", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XZI6", "map_id": "Q9XZI6", "name": "unc-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658373", "map_id": "none", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658364", "map_id": "A0A486WXX8", "name": "dab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10658369", "map_id": "Q21948", "name": "LRP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020010", "map_id": "WBGene00020010", "name": "LRP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658371", "map_id": "none", "name": "LRP2:DAB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21948", "map_id": "Q21948", "name": "LRP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658436", "map_id": "none", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658414", "map_id": "none", "name": "TOR1 hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45271", "map_id": "O45271", "name": "tor-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006597", "map_id": "WBGene00006597", "name": "tor-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXG5", "map_id": "Q9XXG5", "name": "tor-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006598", "map_id": "WBGene00006598", "name": "tor-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95NU5", "map_id": "Q95NU5", "name": "ooc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003870", "map_id": "WBGene00003870", "name": "ooc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658396", "map_id": "P90761", "name": "unc-41", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10658434", "map_id": "none", "name": "NEDD8-STONs:TOR1 hexamer:COP9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10658849", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10641905", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658843", "map_id": "none", "name": "AP-2 cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XTT3", "map_id": "Q9XTT3", "name": "scav-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013039", "map_id": "WBGene00013039", "name": "scav-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11124", "map_id": "Q11124", "name": "SCARB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015389", "map_id": "WBGene00015389", "name": "SCARB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658845", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658847", "map_id": "none", "name": "AP2:chlorpromazine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9648300", "map_id": "LigandDisplayForward?ligandId=83", "name": "chlorpromazine", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10658795", "map_id": "none", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618740", "map_id": "P51485", "name": "arr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10658791", "map_id": "none", "name": "ARRB-binding GPCRs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658867", "map_id": "none", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658821", "map_id": "none", "name": "EPS15,EPN1,EPN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658863", "map_id": "none", "name": "ubiquitinated cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658865", "map_id": "none", "name": "EPS15,EPN1,EPN2:ubiquitinated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658441", "map_id": "none", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648614", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10658825", "map_id": "none", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658815", "map_id": "none", "name": "UBQLN2,1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658823", "map_id": "none", "name": "UNQLNs:UIM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10665766", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10658439", "map_id": "none", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601944", "map_id": "none", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:58681", "name": "PRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601941", "map_id": "none", "name": "PPAT dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17909", "map_id": "CHEBI:17909", "name": "CHEBI:17909", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22134", "map_id": "Q22134", "name": "ppat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011407", "map_id": "WBGene00011407", "name": "ppat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665762", "map_id": "none", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678719", "map_id": "none", "name": "IMPDH inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6832", "map_id": "LigandDisplayForward?ligandId=6832", "name": "LigandDisplayForward?ligandId=6832", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6845", "map_id": "LigandDisplayForward?ligandId=6845", "name": "LigandDisplayForward?ligandId=6845", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6842", "map_id": "LigandDisplayForward?ligandId=6842", "name": "LigandDisplayForward?ligandId=6842", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601887", "map_id": "none", "name": "IMPDH tetramers:IMPDH inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601903", "map_id": "none", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111409", "map_id": "CHEBI:58475", "name": "AICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_419151", "map_id": "CHEBI:57454", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111427", "map_id": "CHEBI:58467", "name": "FAICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601897", "map_id": "none", "name": "ATIC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95QQ4", "map_id": "Q95QQ4", "name": "atic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016957", "map_id": "WBGene00016957", "name": "atic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601889", "map_id": "none", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111584", "map_id": "CHEBI:57464", "name": "XMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604753", "map_id": "none", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604749", "map_id": "none", "name": "PPAT tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601877", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601874", "map_id": "Q09580", "name": "gmps-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601946", "map_id": "none", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:57567", "name": "ADS", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601910", "map_id": "none", "name": "ADSL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21774", "map_id": "Q21774", "name": "adsl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011064", "map_id": "WBGene00011064", "name": "adsl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601926", "map_id": "none", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111370", "map_id": "CHEBI:137981", "name": "AIR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111395", "map_id": "CHEBI:77657", "name": "CAIR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601920", "map_id": "none", "name": "PAICS octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10457", "map_id": "Q10457", "name": "pacs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015116", "map_id": "WBGene00015116", "name": "pacs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601590", "map_id": "none", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111629", "map_id": "CHEBI:57538", "name": "OMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601587", "map_id": "none", "name": "UMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDZ2", "map_id": "G5EDZ2", "name": "umps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011559", "map_id": "WBGene00011559", "name": "umps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601923", "map_id": "none", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111399", "map_id": "CHEBI:58443", "name": "SAICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604751", "map_id": "none", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601934", "map_id": "none", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111354", "map_id": "CHEBI:147286", "name": "N-Formyl-GAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111369", "map_id": "CHEBI:147287", "name": "FGAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601931", "map_id": "Q19311", "name": "pfas-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008654", "map_id": "WBGene00008654", "name": "pfas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601593", "map_id": "none", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76632", "map_id": "CHEBI:30839", "name": "ORO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601900", "map_id": "none", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601913", "map_id": "none", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10604785", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604782", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91134", "map_id": "P91134", "name": "adss-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016509", "map_id": "WBGene00016509", "name": "adss-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601603", "map_id": "none", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76630", "map_id": "CHEBI:30864", "name": "(S)-DHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601600", "map_id": "none", "name": "DHODH:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O01815", "map_id": "O01815", "name": "dhod-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020932", "map_id": "WBGene00020932", "name": "dhod-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644465", "map_id": "none", "name": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10644461", "map_id": "none", "name": "SERPINE2:GAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_977180", "map_id": "CHEBI:18085", "name": "GAG", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10605673", "map_id": "none", "name": "activated thrombin (factor IIa)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10644463", "map_id": "none", "name": "SERPINE2:GAG:activated thrombin (factor IIa)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658612", "map_id": "none", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658609", "map_id": "none", "name": "MICAL1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061AD47", "map_id": "A0A061AD47", "name": "tag-273", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013289", "map_id": "WBGene00013289", "name": "tag-273", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10628378", "map_id": "none", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159448", "map_id": "CHEBI:456215", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10628375", "map_id": "Q09629", "name": "AK3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00014058", "map_id": "WBGene00014058", "name": "AK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623673", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623615", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYR1", "map_id": "H2KYR1", "name": "vig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006924", "map_id": "WBGene00006924", "name": "vig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23551", "map_id": "Q23551", "name": "unc-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006759", "map_id": "WBGene00006759", "name": "unc-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3B0", "map_id": "Q9N3B0", "name": "manf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021888", "map_id": "WBGene00021888", "name": "manf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17939", "map_id": "O17939", "name": "aipl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010685", "map_id": "WBGene00010685", "name": "aipl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623671", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10613311", "map_id": "none", "name": "Interaction of Tie2 and Ang4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10613293", "map_id": "none", "name": "Homologues of TEK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613307", "map_id": "none", "name": "Homologues of ANGPT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10613309", "map_id": "none", "name": "ANGPT4:TEK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618750", "map_id": "none", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618748", "map_id": "none", "name": "F2R:ARRB1:MAPKs:SRC-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628230", "map_id": "none", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628228", "map_id": "none", "name": "Kinesin-3 monomers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628138", "map_id": "none", "name": "Kinesin-3 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618759", "map_id": "none", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618742", "map_id": "none", "name": "F2R:ARRB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605677", "map_id": "none", "name": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10605667", "map_id": "none", "name": "SERPINC1:SERPINC1 activators", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6811", "map_id": "LigandDisplayForward?ligandId=6811", "name": "LigandDisplayForward?ligandId=6811", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6804", "map_id": "LigandDisplayForward?ligandId=6804", "name": "LigandDisplayForward?ligandId=6804", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6819", "map_id": "LigandDisplayForward?ligandId=6819", "name": "LigandDisplayForward?ligandId=6819", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=4214", "map_id": "LigandDisplayForward?ligandId=4214", "name": "LigandDisplayForward?ligandId=4214", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6803", "map_id": "LigandDisplayForward?ligandId=6803", "name": "LigandDisplayForward?ligandId=6803", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6846", "map_id": "LigandDisplayForward?ligandId=6846", "name": "LigandDisplayForward?ligandId=6846", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605675", "map_id": "none", "name": "thrombin:SERPINC1:SERPINC1 activators", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614194", "map_id": "none", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614189", "map_id": "none", "name": "SOS-1 bound to Tie2:Grb2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613017", "map_id": "none", "name": "CyP60 chaperones Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10613013", "map_id": "P52012", "name": "cyn-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "WBGene00000880", "map_id": "WBGene00000880", "name": "cyn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613008", "map_id": "none", "name": "Homologues of BSG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10613015", "map_id": "none", "name": "CyP60 complexed with Basigin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P52012", "map_id": "P52012", "name": "cyn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613023", "map_id": "none", "name": "Caveolin-1 binds Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10613019", "map_id": "Q94051", "name": "cav-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10613021", "map_id": "none", "name": "Caveolin-1 bound to Basigin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10605482", "map_id": "none", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605480", "map_id": "none", "name": "Activated conventional protein kinase C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620840", "map_id": "none", "name": "PECAM-1 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613771", "map_id": "O01761", "name": "phospho-unc-89", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10620838", "map_id": "none", "name": "p-PECAM:PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618110", "map_id": "none", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605490", "map_id": "none", "name": "Thrombin-activated PAR:Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605439", "map_id": "H2KZ99", "name": "gnrr-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10623452", "map_id": "none", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623438", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "species_10623450", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612267", "map_id": "none", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612263", "map_id": "none", "name": "Integrin alpha5beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612257", "map_id": "none", "name": "FN1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10612265", "map_id": "none", "name": "Integrin alpha5beta1:FN1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613785", "map_id": "none", "name": "Trans-homophilic interaction of PECAM-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613781", "map_id": "O01761", "name": "unc-89", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10613783", "map_id": "none", "name": "PECAM1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618771", "map_id": "none", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618767", "map_id": "none", "name": "F2R:ARRB2:MAPKs:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613301", "map_id": "none", "name": "Interaction of Tie2 and p85 of PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613255", "map_id": "none", "name": "ANGPT1:p-5Y,S119-TEK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613299", "map_id": "none", "name": "p85 bound to Tie2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613325", "map_id": "none", "name": "Interaction of Tie2 and Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613323", "map_id": "none", "name": "Grb2 bound to Tie2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620439", "map_id": "none", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane" }, { "id": "species_114565", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "false" }, { "id": "species_10620436", "map_id": "Q19625", "name": "mrp-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "false" }, { "id": "reaction_10628226", "map_id": "none", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628152", "map_id": "Q9XUS9", "name": "cyk-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628147", "map_id": "Q8MQ03", "name": "zen-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628154", "map_id": "none", "name": "Centralspindlin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628373", "map_id": "none", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628369", "map_id": "none", "name": "NF-E2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B0M0M9", "map_id": "B0M0M9", "name": "maf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077521", "map_id": "WBGene00077521", "name": "maf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1008228", "map_id": "none", "name": "Promotor region of beta-globin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628371", "map_id": "none", "name": "NF-E2:Promoter region of beta-globin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628113", "map_id": "none", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628107", "map_id": "P34540", "name": "unc-116", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628102", "map_id": "none", "name": "KLC1,KLC2,KLC3,KLC4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628111", "map_id": "none", "name": "Kinesin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625054", "map_id": "none", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625050", "map_id": "P34686", "name": "cap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625045", "map_id": "P34685", "name": "cap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625052", "map_id": "none", "name": "F-actin capping protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623288", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623154", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "P91917", "map_id": "P91917", "name": "ola-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012344", "map_id": "WBGene00012344", "name": "ola-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22174", "map_id": "Q22174", "name": "GTPBP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011449", "map_id": "WBGene00011449", "name": "GTPBP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01764", "map_id": "O01764", "name": "lron-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018157", "map_id": "WBGene00018157", "name": "lron-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21154", "map_id": "Q21154", "name": "moma-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019333", "map_id": "WBGene00019333", "name": "moma-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09387", "map_id": "Q09387", "name": "FAM49B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019944", "map_id": "WBGene00019944", "name": "FAM49B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZE9", "map_id": "Q9GZE9", "name": "ldp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017719", "map_id": "WBGene00017719", "name": "ldp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623286", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10605543", "map_id": "none", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605540", "map_id": "Q22070", "name": "phospho-plc-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10613779", "map_id": "none", "name": "Interaction of PECAM-1 and PLC gamma1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613777", "map_id": "none", "name": "PECAM-1:PLC gamma1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613000", "map_id": "none", "name": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612996", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612998", "map_id": "none", "name": "BSG:Integrin alpha3beta1, alpha6beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621291", "map_id": "none", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10666074", "map_id": "none", "name": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10666070", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10666072", "map_id": "H2KZ99", "name": "gnrr-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10618735", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10618769", "map_id": "none", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618763", "map_id": "none", "name": "F2R:ARRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613800", "map_id": "none", "name": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613789", "map_id": "none", "name": "p-Y663,Y686-PECAM1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621374", "map_id": "none", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621366", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621368", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621371", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623417", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623365", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "Q23030", "map_id": "Q23030", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019986", "map_id": "WBGene00019986", "name": "CTSW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16454", "map_id": "O16454", "name": "tag-196", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007055", "map_id": "WBGene00007055", "name": "tag-196", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2X1", "map_id": "Q9U2X1", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q688B0", "map_id": "Q688B0", "name": "FAM3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019786", "map_id": "WBGene00019786", "name": "FAM3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18740", "map_id": "Q18740", "name": "tag-329", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008231", "map_id": "WBGene00008231", "name": "tag-329", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0F2", "map_id": "H2L0F2", "name": "CDC37L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019497", "map_id": "WBGene00019497", "name": "CDC37L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXQ7", "map_id": "Q9XXQ7", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21810", "map_id": "Q21810", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623415", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10628271", "map_id": "none", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628267", "map_id": "none", "name": "Dual-specific AKAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10955", "map_id": "Q10955", "name": "rgs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004348", "map_id": "WBGene00004348", "name": "rgs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XS0", "map_id": "Q95XS0", "name": "eri-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021419", "map_id": "WBGene00021419", "name": "eri-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09285", "map_id": "Q09285", "name": "akap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016977", "map_id": "WBGene00016977", "name": "akap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19731", "map_id": "Q19731", "name": "ekl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009052", "map_id": "WBGene00009052", "name": "ekl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628269", "map_id": "none", "name": "Dual-specific AKAPs:PKA tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605796", "map_id": "none", "name": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10605792", "map_id": "G5EBU2", "name": "XG314", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020921", "map_id": "WBGene00020921", "name": "XG314", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605794", "map_id": "none", "name": "activated thrombin:thrombomodulin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBU2", "map_id": "G5EBU2", "name": "XG314", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605559", "map_id": "none", "name": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10605545", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10605547", "map_id": "H2KZ99", "name": "gnrr-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10613027", "map_id": "none", "name": "Basigin homodimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613025", "map_id": "none", "name": "BSG dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659424", "map_id": "none", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8869207", "map_id": "CHEBI:91144", "name": "lyso-PAF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10659421", "map_id": "none", "name": "Homologues of PAFAH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q22943", "map_id": "Q22943", "name": "paf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003907", "map_id": "WBGene00003907", "name": "paf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGT1", "map_id": "G5EGT1", "name": "paf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003906", "map_id": "WBGene00003906", "name": "paf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665500", "map_id": "none", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10665498", "map_id": "none", "name": "Homologues of SERPING1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10623242", "map_id": "none", "name": "Homologues of SERPING1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10618108", "map_id": "none", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605488", "map_id": "none", "name": "Thrombin-activated PARs:Gq (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605492", "map_id": "none", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10644326", "map_id": "none", "name": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10644322", "map_id": "none", "name": "Homologues of SERPIND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10644324", "map_id": "none", "name": "activated thrombin (factor IIa):SERPIND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10605697", "map_id": "none", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10605695", "map_id": "none", "name": "Homologues of SERPINC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9693058", "map_id": "none", "name": "SERPINC1 activators", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628243", "map_id": "none", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10628237", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10628241", "map_id": "none", "name": "Mitofusin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10612983", "map_id": "none", "name": "Basigin binds MCT1, MCT3 and MCT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612973", "map_id": "none", "name": "Monocarboxylate Transporter Set (MCT)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628232", "map_id": "none", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628170", "map_id": "Q9XU12", "name": "klp-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628178", "map_id": "none", "name": "Kinesin-13 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638020", "map_id": "none", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10638016", "map_id": "Q19459", "name": "GLG1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008800", "map_id": "WBGene00008800", "name": "GLG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638011", "map_id": "A0A1N7SYP5", "name": "SELE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10638018", "map_id": "none", "name": "2xSELE ligands:SELE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19459", "map_id": "Q19459", "name": "GLG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613297", "map_id": "none", "name": "Interaction of Tie2 with Ang1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10613107", "map_id": "none", "name": "Homologues of ANGPT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10613295", "map_id": "none", "name": "ANGPT1:TEK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612243", "map_id": "none", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612239", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(39-691)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10612233", "map_id": "Q9XVQ7", "name": "MERTK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10612241", "map_id": "none", "name": "MERTK:MERKT ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620845", "map_id": "none", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620842", "map_id": "G5EE56", "name": "src-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10620455", "map_id": "none", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620453", "map_id": "Q22070", "name": "plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10605787", "map_id": "none", "name": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10605742", "map_id": "none", "name": "thrombin:cleaved SERPINC1:SERPINC1 activators", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605785", "map_id": "none", "name": "thrombin:cleaved SERPINC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10621362", "map_id": "none", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621354", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621356", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618757", "map_id": "none", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618754", "map_id": "none", "name": "F2R:ARRB1:active MAPKs:active SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621249", "map_id": "none", "name": "PECAM1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10605527", "map_id": "none", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605516", "map_id": "none", "name": "Homologues of STXBP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605524", "map_id": "none", "name": "Homologues of p-STXBP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664445", "map_id": "none", "name": "Factor IIa inhibitors (peptide) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9603327", "map_id": "none", "name": "Factor IIa inhibitors (peptide)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6458", "map_id": "LigandDisplayForward?ligandId=6458", "name": "LigandDisplayForward?ligandId=6458", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6469", "map_id": "LigandDisplayForward?ligandId=6469", "name": "LigandDisplayForward?ligandId=6469", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6470", "map_id": "LigandDisplayForward?ligandId=6470", "name": "LigandDisplayForward?ligandId=6470", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10664443", "map_id": "none", "name": "Factor IIa inhibitors (peptide):IIa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10605745", "map_id": "none", "name": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10618765", "map_id": "none", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10613775", "map_id": "none", "name": "Interaction of PECAM-1 and SHP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613445", "map_id": "G5EC24", "name": "ptp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613773", "map_id": "none", "name": "PECAM-1:SHP-1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613321", "map_id": "none", "name": "Interaction of Tie2 with Ang2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10613317", "map_id": "none", "name": "Homologues of ANGPT2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10613319", "map_id": "none", "name": "ANGPT2:TEK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628426", "map_id": "none", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628420", "map_id": "none", "name": "DOCK-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628422", "map_id": "none", "name": "RAC1, CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628424", "map_id": "none", "name": "DOCK-GEFs:RAC1, CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618744", "map_id": "none", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10628222", "map_id": "none", "name": "Kinesins bind microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628216", "map_id": "none", "name": "Kinesins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10663939", "map_id": "none", "name": "Factor IIa inhibitors (compounds) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9603311", "map_id": "none", "name": "Factor IIa inhibitors (compounds)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6382", "map_id": "LigandDisplayForward?ligandId=6382", "name": "LigandDisplayForward?ligandId=6382", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6385", "map_id": "LigandDisplayForward?ligandId=6385", "name": "LigandDisplayForward?ligandId=6385", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6380", "map_id": "LigandDisplayForward?ligandId=6380", "name": "LigandDisplayForward?ligandId=6380", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8760", "map_id": "LigandDisplayForward?ligandId=8760", "name": "LigandDisplayForward?ligandId=8760", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10663937", "map_id": "none", "name": "Factor IIa inhibitors (compounds):IIa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10605466", "map_id": "none", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605453", "map_id": "none", "name": "Thrombin activated PAR:G12/13 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605463", "map_id": "none", "name": "Thrombin activated PAR:G12/13 (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615894", "map_id": "none", "name": "Basigin binds Mannose-carrying cell recognition molecules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615890", "map_id": "none", "name": "Mannose-carrying cell recognition molecules", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XUG9", "map_id": "Q9XUG9", "name": "nkb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008074", "map_id": "WBGene00008074", "name": "nkb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93235", "map_id": "Q93235", "name": "nkb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007646", "map_id": "WBGene00007646", "name": "nkb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615892", "map_id": "none", "name": "Basigin:Mannose-carrying cell recognition molecules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628291", "map_id": "none", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628287", "map_id": "none", "name": "Histone H3 methylated at lysine-9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628276", "map_id": "P34618", "name": "cec-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000414", "map_id": "WBGene00000414", "name": "cec-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628289", "map_id": "none", "name": "HP1alpha:Histone H3 methylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34618", "map_id": "P34618", "name": "cec-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618114", "map_id": "none", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10628300", "map_id": "none", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628296", "map_id": "Q21301", "name": "crml-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010641", "map_id": "WBGene00010641", "name": "crml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628298", "map_id": "none", "name": "LRRC16A:F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21301", "map_id": "Q21301", "name": "crml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614187", "map_id": "none", "name": "Dimerization of Tie2/Ang1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614185", "map_id": "none", "name": "2xANGPT1:TEK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615042", "map_id": "none", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10615034", "map_id": "none", "name": "PSAP,CHID1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q18607", "map_id": "Q18607", "name": "chil-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016642", "map_id": "WBGene00016642", "name": "chil-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615040", "map_id": "none", "name": "PSAP,CHID1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10628341", "map_id": "none", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628337", "map_id": "none", "name": "BHC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628314", "map_id": "none", "name": "REST:REST DNA binding sites", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628339", "map_id": "none", "name": "BHC complex:REST:REST DNA binding sites", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10621346", "map_id": "none", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621334", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621336", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621344", "map_id": "none", "name": "PIP3:VAV1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621342", "map_id": "none", "name": "VAV family:PIP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10628396", "map_id": "none", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10628392", "map_id": "W6SBE5", "name": "rabs-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00021538", "map_id": "WBGene00021538", "name": "rabs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628383", "map_id": "G5ECC3", "name": "rme-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00004373", "map_id": "WBGene00004373", "name": "rme-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628394", "map_id": "none", "name": "C-terminal EH domain containing proteins:Rabenosyn-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "W6SBE5", "map_id": "W6SBE5", "name": "rabs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECC3", "map_id": "G5ECC3", "name": "rme-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10628220", "map_id": "none", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10628224", "map_id": "none", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628143", "map_id": "G5ECF4", "name": "bmk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628145", "map_id": "none", "name": "Kinesin-5 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623550", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623520", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "Q9N4L6", "map_id": "Q9N4L6", "name": "TMX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022836", "map_id": "WBGene00022836", "name": "TMX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91855", "map_id": "P91855", "name": "PHACTR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009174", "map_id": "WBGene00009174", "name": "PHACTR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623548", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613808", "map_id": "none", "name": "Interaction of integrin alphaVbeta3 with PECAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613804", "map_id": "none", "name": "Integrin alphaVbeta3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10613806", "map_id": "none", "name": "Integrin alphaVbeta3:PECAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614191", "map_id": "none", "name": "Interaction of SOS-1 to Tie2 bound Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10628941", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628811", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628835", "map_id": "none", "name": "PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBV0", "map_id": "G5EBV0", "name": "egl-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001178", "map_id": "WBGene00001178", "name": "egl-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10628943", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628853", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628909", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628884", "map_id": "none", "name": "PHD1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628945", "map_id": "none", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628863", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628939", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628931", "map_id": "none", "name": "ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628818", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628921", "map_id": "none", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628907", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628917", "map_id": "none", "name": "VHL:EloB,C:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628919", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628866", "map_id": "none", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628837", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628887", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628855", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10628874", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10628934", "map_id": "none", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628927", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10628925", "map_id": "none", "name": "UBE2D1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10628843", "map_id": "none", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628839", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10628841", "map_id": "none", "name": "VBC complex (with or without LIMD1)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10628937", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628849", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628814", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636006", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10636003", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10636398", "map_id": "none", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213221", "map_id": "none", "name": "Antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10636395", "map_id": "P34276", "name": "IFI30", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00015336", "map_id": "WBGene00015336", "name": "IFI30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627920", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627918", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N593", "map_id": "Q9N593", "name": "mat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003132", "map_id": "WBGene00003132", "name": "mat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1Q249", "map_id": "B1Q249", "name": "RNF19B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021721", "map_id": "WBGene00021721", "name": "RNF19B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS3", "map_id": "Q9XUS3", "name": "pdr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003967", "map_id": "WBGene00003967", "name": "pdr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q65XX2", "map_id": "Q65XX2", "name": "LTN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021831", "map_id": "WBGene00021831", "name": "LTN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLA2", "map_id": "V6CLA2", "name": "hecd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016405", "map_id": "WBGene00016405", "name": "hecd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20874", "map_id": "Q20874", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018964", "map_id": "WBGene00018964", "name": "RNF144B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90990", "map_id": "P90990", "name": "trul-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015194", "map_id": "WBGene00015194", "name": "trul-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17736", "map_id": "O17736", "name": "etc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008429", "map_id": "WBGene00008429", "name": "etc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21106", "map_id": "Q21106", "name": "dcaf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014243", "map_id": "WBGene00014243", "name": "dcaf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20052", "map_id": "Q20052", "name": "apc-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000145", "map_id": "WBGene00000145", "name": "apc-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34514", "map_id": "P34514", "name": "apc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000143", "map_id": "WBGene00000143", "name": "apc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYV3", "map_id": "Q9TYV3", "name": "TRAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021074", "map_id": "WBGene00021074", "name": "TRAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19294", "map_id": "Q19294", "name": "mat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003134", "map_id": "WBGene00003134", "name": "mat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2WF61", "map_id": "Q2WF61", "name": "ANAPC10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044345", "map_id": "WBGene00044345", "name": "ANAPC10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17750", "map_id": "Q17750", "name": "ufl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015555", "map_id": "WBGene00015555", "name": "ufl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECZ8", "map_id": "G5ECZ8", "name": "mpz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003404", "map_id": "WBGene00003404", "name": "mpz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXE6", "map_id": "Q9XXE6", "name": "oxi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003898", "map_id": "WBGene00003898", "name": "oxi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAQ3", "map_id": "Q9UAQ3", "name": "madd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016539", "map_id": "WBGene00016539", "name": "madd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IJV5", "map_id": "A0A4V0IJV5", "name": "frm-5.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021406", "map_id": "WBGene00021406", "name": "frm-5.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62235", "map_id": "O62235", "name": "rbpl-1", "type": "complex_component", 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983032", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (8-16aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628071", "map_id": "none", "name": "IFN gamma stimulated aminopeptidases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22317", "map_id": "Q22317", "name": "anp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011587", "map_id": "WBGene00011587", "name": "anp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVV9", "map_id": "Q9XVV9", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022073", "map_id": "WBGene00022073", "name": "ERAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0M5", "map_id": "H2L0M5", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5A631", "map_id": "A5A631", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46557", "map_id": "P46557", "name": "mnp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007139", "map_id": "WBGene00007139", "name": "mnp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAA0", "map_id": "Q9NAA0", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17405", "map_id": "Q17405", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2H2", "map_id": "Q9U2H2", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGH4", "map_id": "G5EGH4", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09541", "map_id": "Q09541", "name": "tpp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017686", "map_id": "WBGene00017686", "name": "tpp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22531", "map_id": "Q22531", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625487", "map_id": "none", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618059", "map_id": "H2L055", "name": "RAP1GAP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018734", "map_id": "WBGene00018734", "name": "phospho-p-S7-RAP1GAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618070", "map_id": "none", "name": "14-3-3 beta, zeta", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618072", "map_id": "none", "name": "RAP1GAP2:14-3-3beta, zeta", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L055", "map_id": "H2L055", "name": "phospho-p-S7-RAP1GAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625485", "map_id": "H2L055", "name": "phospho-p-S7-RAP1GAP2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10627949", "map_id": "none", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10628590", "map_id": "none", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605468", "map_id": "P90980", "name": "pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605476", "map_id": "none", "name": "Activated PKC beta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625498", "map_id": "none", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625495", "map_id": "none", "name": "PKA catalytic subunits, PKG type I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612908", "map_id": "none", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10612906", "map_id": "none", "name": "SAR1B:GTP:SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10627862", "map_id": "none", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627910", "map_id": "none", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983034", "map_id": "CHEBI:25676", "name": "oligopeptide fragment", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10627907", "map_id": "none", "name": "TAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O18227", "map_id": "O18227", "name": "haf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001818", "map_id": "WBGene00001818", "name": "haf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZD9", "map_id": "Q9TZD9", "name": "haf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001814", "map_id": "WBGene00001814", "name": "haf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U275", "map_id": "Q9U275", "name": "haf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001817", "map_id": "WBGene00001817", "name": "haf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02086", "map_id": "O02086", "name": "haf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001812", "map_id": "WBGene00001812", "name": "haf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44897", "map_id": "O44897", "name": "haf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001819", "map_id": "WBGene00001819", "name": "haf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627922", "map_id": "none", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10628040", "map_id": "none", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983033", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8943716", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10628037", "map_id": "none", "name": "ERAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10618074", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618061", "map_id": "none", "name": "Rap1 GTPase-activating proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L2C2", "map_id": "H2L2C2", "name": "sipa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012100", "map_id": "WBGene00012100", "name": "sipa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633105", "map_id": "none", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633263", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633260", "map_id": "none", "name": "PIK3(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659805", "map_id": "none", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10614984", "map_id": "G5EFK4", "name": "arf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10659801", "map_id": "none", "name": "PLEKHA3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9BKS2", "map_id": "Q9BKS2", "name": "PLEKHA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022347", "map_id": "WBGene00022347", "name": "PLEKHA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659803", "map_id": "none", "name": "ARF1:PLEKHA3,8:PI4P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656373", "map_id": "none", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656346", "map_id": "Q965W9", "name": "mtm-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003479", "map_id": "WBGene00003479", "name": "mtm-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10633219", "map_id": "G5ED68", "name": "mtm-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "F53A2.8a", "map_id": "F53A2.8a", "name": "mtm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656371", "map_id": "none", "name": "MTMR6:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965W9", "map_id": "Q965W9", "name": "mtm-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED68", "map_id": "G5ED68", "name": "mtm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633324", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10633221", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633290", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10633287", "map_id": "none", "name": "PIP4K2/5K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656350", "map_id": "none", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656341", "map_id": "G5ED68", "name": "mtm-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656348", "map_id": "none", "name": "MTMR8:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633206", "map_id": "none", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633203", "map_id": "none", "name": "INPP5(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656378", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10656375", "map_id": "none", "name": "MTMR6:MTMR9,MTMR8:MTMR9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633035", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633224", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633132", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633129", "map_id": "none", "name": "SYNJs,OCRL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633316", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633313", "map_id": "none", "name": "SYNJ/INPP5(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633243", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633240", "map_id": "none", "name": "PIK3C(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10656381", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633282", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633311", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633306", "map_id": "none", "name": "INPP4A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21623", "map_id": "Q21623", "name": "INPP4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010975", "map_id": "WBGene00010975", "name": "INPP4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633293", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10633080", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633077", "map_id": "none", "name": "PI4K2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633213", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10605252", "map_id": "none", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605235", "map_id": "none", "name": "Elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TXQ9", "map_id": "Q9TXQ9", "name": "eaf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017011", "map_id": "WBGene00017011", "name": "eaf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19375", "map_id": "Q19375", "name": "IWS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008729", "map_id": "WBGene00008729", "name": "IWS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBY0", "map_id": "G5EBY0", "name": "rtfo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009103", "map_id": "WBGene00009103", "name": "rtfo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03560", "map_id": "Q03560", "name": "ctr-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007184", "map_id": "WBGene00007184", "name": "ctr-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34703", "map_id": "P34703", "name": "emb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001259", "map_id": "WBGene00001259", "name": "emb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90783", "map_id": "P90783", "name": "pafo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008338", "map_id": "WBGene00008338", "name": "pafo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605250", "map_id": "none", "name": "Processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605237", "map_id": "none", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605233", "map_id": "P34703", "name": "emb-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605191", "map_id": "none", "name": "Elongin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605151", "map_id": "none", "name": "Early elongation complex with hyperphosphorylated Pol II CTD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605156", "map_id": "P52652", "name": "TCEA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605228", "map_id": "Q19375", "name": "IWS1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605223", "map_id": "none", "name": "PAF1C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605248", "map_id": "none", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605131", "map_id": "Q95QG8", "name": "fcp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605241", "map_id": "none", "name": "RNA Pol II (hypophosphorylated):capped pre-mRNA complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605284", "map_id": "none", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605262", "map_id": "none", "name": "Elongation complex prior to separation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605278", "map_id": "none", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605126", "map_id": "none", "name": "DSIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605243", "map_id": "none", "name": "RNA Pol II (hypophosphorylated) complex bound to DSIF protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605266", "map_id": "none", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605264", "map_id": "none", "name": "Elongation complex with separated and uncleaved transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602928", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602925", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611542", "map_id": "none", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611530", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10611537", "map_id": "none", "name": "Btn-p-S79-ACACB:2Mn2+ polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10611539", "map_id": "none", "name": "AMPK heterotrimer (active)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611550", "map_id": "none", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_201023", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_201050", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611547", "map_id": "Q27257", "name": "dif-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00000996", "map_id": "WBGene00000996", "name": "dif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606867", "map_id": "none", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10606864", "map_id": "none", "name": "Homologues of SLC22A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660206", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611457", "map_id": "none", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_77281", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611454", "map_id": "G5ECS9", "name": "cpt-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011122", "map_id": "WBGene00011122", "name": "cpt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10645970", "map_id": "none", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10645966", "map_id": "none", "name": "RAB11A:GTP:Golgi derived vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "species_10645968", "map_id": "none", "name": "RAB3IP:RAB11A:GTP:Golgi-derived vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10640972", "map_id": "none", "name": "Tetrastatin binds integrin alphaVbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10630428", "map_id": "P17139", "name": "emb-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10640970", "map_id": "none", "name": "Tetrastatin:Integrin alphaVbeta3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614491", "map_id": "none", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614485", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614489", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614512", "map_id": "none", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614477", "map_id": "none", "name": "Integrin alpha8beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614508", "map_id": "none", "name": "Tenascin-C hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10614510", "map_id": "none", "name": "Integrin alpha8beta1:Tenascin-C hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640917", "map_id": "none", "name": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10640889", "map_id": "none", "name": "Integrins alphaVbeta3, alpha3beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640891", "map_id": "P17139", "name": "emb-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10640915", "map_id": "none", "name": "Tumstatin:Integrins alphaVbeta3, alpha3beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614720", "map_id": "none", "name": "Interaction of integrin alphaVbeta3 with Tenascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614506", "map_id": "Q18096", "name": "TNC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10614718", "map_id": "none", "name": "Integrin alphaVbeta3:Tenascin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614895", "map_id": "none", "name": "Interaction of integrin alphaIIbbeta3 with Fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614893", "map_id": "none", "name": "Integrin alpha2bbeta3:FN1(32-2386)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10623717", "map_id": "none", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10623712", "map_id": "none", "name": "PXLP-K341-GPT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O01685", "map_id": "O01685", "name": "PXLP-K341-GPT2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016333", "map_id": "WBGene00016333", "name": "PXLP-K341-GPT2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598702", "map_id": "none", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598697", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619814", "map_id": "none", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426523", "map_id": "none", "name": "RNA (exact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_426511", "map_id": "none", "name": "Cleaved RNA with 5' Phosphate and 3' Hydroxyl", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619801", "map_id": "none", "name": "Endonucleolytic RISC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10631293", "map_id": "none", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1535904", "map_id": "none", "name": "FoxO3a-binding Element", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10631291", "map_id": "none", "name": "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622295", "map_id": "none", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10622293", "map_id": "none", "name": "pp38 alpha/beta/gamma:ABL1:JLP:CDO complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34609", "map_id": "P34609", "name": "unc-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006755", "map_id": "WBGene00006755", "name": "unc-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622291", "map_id": "none", "name": "ABL1:JLP:CDO complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10622230", "map_id": "none", "name": "phospho-p38 alpha/beta/gamma MAPK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622324", "map_id": "none", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622320", "map_id": "none", "name": "Myod:phospho-E heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EEG9", "map_id": "G5EEG9", "name": "phospho-hlh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001949", "map_id": "WBGene00001949", "name": "phospho-hlh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22980", "map_id": "P22980", "name": "hlh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001948", "map_id": "WBGene00001948", "name": "hlh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622241", "map_id": "none", "name": "phospho-MEF2 proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U325", "map_id": "Q9U325", "name": "phospho-mef-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003182", "map_id": "WBGene00003182", "name": "phospho-mef-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622322", "map_id": "none", "name": "MyoD:phospho-E:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10615948", "map_id": "none", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615942", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615944", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615946", "map_id": "none", "name": "CDO:BOC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622246", "map_id": "none", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622214", "map_id": "Q9U325", "name": "mef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10622243", "map_id": "none", "name": "phospho p38:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10666234", "map_id": "none", "name": "MTTP binds lomitapide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9737774", "map_id": "LigandDisplayForward?ligandId=7439", "name": "lomitapide", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10666230", "map_id": "none", "name": "MTTP:PDI:lipid complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:16247", "map_id": "CHEBI:16247", "name": "CHEBI:16247", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECG7", "map_id": "G5ECG7", "name": "dsc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001099", "map_id": "WBGene00001099", "name": "dsc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10666232", "map_id": "none", "name": "MTTP:lomitapide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10659889", "map_id": "none", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10659881", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002783", "map_id": "WBGene00002783", "name": "let-607", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659887", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10659903", "map_id": "none", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10659901", "map_id": "O44743", "name": "let-607", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10659897", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10659885", "map_id": "none", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10659879", "map_id": "O44743", "name": "let-607", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10659883", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10619081", "map_id": "Q9U227", "name": "MBTPS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00013225", "map_id": "WBGene00013225", "name": "MBTPS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637200", "map_id": "none", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10631810", "map_id": "O77469", "name": "fbl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00001403", "map_id": "WBGene00001403", "name": "fbl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637198", "map_id": "none", "name": "FBLN1, FBLN2:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O77469", "map_id": "O77469", "name": "fbl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660724", "map_id": "none", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932979", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10660721", "map_id": "none", "name": "SERINC3,5,(1,2,4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45719", "map_id": "O45719", "name": "SERINC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021956", "map_id": "WBGene00021956", "name": "SERINC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XV3", "map_id": "Q95XV3", "name": "SERINC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663928", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663925", "map_id": "none", "name": "PXLP-K56-SRR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93968", "map_id": "Q93968", "name": "serr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011353", "map_id": "WBGene00011353", "name": "serr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663931", "map_id": "none", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627109", "map_id": "none", "name": "PHGDH tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_977329", "map_id": "CHEBI:30933", "name": "3POPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627106", "map_id": "none", "name": "PHGDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17626", "map_id": "O17626", "name": "PHGDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007836", "map_id": "WBGene00007836", "name": "PHGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664421", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627088", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627085", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061ACK7", "map_id": "A0A061ACK7", "name": "PSPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013379", "map_id": "WBGene00013379", "name": "PSPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627099", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627096", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91856", "map_id": "P91856", "name": "PXLP-K200-PSAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009177", "map_id": "WBGene00009177", "name": "PXLP-K200-PSAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635804", "map_id": "none", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635794", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10635802", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10644304", "map_id": "none", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10644300", "map_id": "none", "name": "AGO1,2:miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10644302", "map_id": "none", "name": "AGO1,2:miRNA:chromatin:RNA pol II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10619797", "map_id": "none", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426463", "map_id": "none", "name": "Double-stranded RNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612563", "map_id": "none", "name": "TARBP2,PRKRA RLC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619794", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex siRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635806", "map_id": "none", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10664156", "map_id": "none", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10635780", "map_id": "none", "name": "AGO2:duplex siRNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10664153", "map_id": "none", "name": "AGO2:cleaved duplex siRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10632756", "map_id": "none", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614518", "map_id": "CHEBI:17482", "name": "L-Cystathionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632730", "map_id": "none", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10632727", "map_id": "none", "name": "PXLP-CBS tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFH8", "map_id": "G5EFH8", "name": "cbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013866", "map_id": "WBGene00013866", "name": "cbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644851", "map_id": "none", "name": "ATAT acetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644843", "map_id": "none", "name": "acetylated microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10644848", "map_id": "O45100", "name": "mec-17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003178", "map_id": "WBGene00003178", "name": "mec-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10644854", "map_id": "none", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643031", "map_id": "Q9U266", "name": "hda-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10633770", "map_id": "none", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023922", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023948", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10633537", "map_id": "none", "name": "IP6K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q93644", "map_id": "Q93644", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009262", "map_id": "WBGene00009262", "name": "IP6K1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02167", "map_id": "O02167", "name": "IP6K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021260", "map_id": "WBGene00021260", "name": "IP6K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKX8", "map_id": "Q9BKX8", "name": "IP6K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633646", "map_id": "none", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023935", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023901", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10633643", "map_id": "O62519", "name": "ipmk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00014081", "map_id": "WBGene00014081", "name": "ipmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633666", "map_id": "none", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023891", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633767", "map_id": "none", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023892", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633669", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023940", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633773", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023907", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633591", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10633588", "map_id": "Q9XXI1", "name": "ippk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012466", "map_id": "WBGene00012466", "name": "ippk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633761", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023941", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633540", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10633626", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10598876", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598873", "map_id": "P41931", "name": "odc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003844", "map_id": "WBGene00003844", "name": "odc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614940", "map_id": "none", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614932", "map_id": "Q9NHZ6", "name": "oaz-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022748", "map_id": "WBGene00022748", "name": "oaz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614938", "map_id": "none", "name": "ODC:OAZ complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NHZ6", "map_id": "Q9NHZ6", "name": "oaz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41931", "map_id": "P41931", "name": "odc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605806", "map_id": "none", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141349", "map_id": "CHEBI:17927", "name": "NASPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141350", "map_id": "CHEBI:17148", "name": "PTCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141327", "map_id": "CHEBI:30322", "name": "3AAPNAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10605803", "map_id": "none", "name": "PAOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10614952", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614949", "map_id": "none", "name": "Homologues of ADC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01579", "map_id": "O01579", "name": "AZIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018764", "map_id": "WBGene00018764", "name": "AZIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615022", "map_id": "none", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353113", "map_id": "CHEBI:15625", "name": "dc-AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615019", "map_id": "O02655", "name": "smd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004875", "map_id": "WBGene00004875", "name": "smd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615014", "map_id": "none", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615011", "map_id": "B4E3X6", "name": "spds-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012909", "map_id": "WBGene00012909", "name": "spds-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615168", "map_id": "none", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10614964", "map_id": "none", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614958", "map_id": "none", "name": "Homologues of AZIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10614962", "map_id": "none", "name": "AZIN1 bound OAZ:ODC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10615006", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615001", "map_id": "O17731", "name": "SAT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008408", "map_id": "WBGene00008408", "name": "SAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615004", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605808", "map_id": "none", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141323", "map_id": "CHEBI:17312", "name": "NASPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10633102", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_10633099", "map_id": "none", "name": "MTM1,MTMR2,MTMR4,MTMR7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633226", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "reaction_10633246", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10665730", "map_id": "none", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608179", "map_id": "none", "name": "CTF18 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21350", "map_id": "Q21350", "name": "ctf-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010676", "map_id": "WBGene00010676", "name": "ctf-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44992", "map_id": "O44992", "name": "dscc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019595", "map_id": "WBGene00019595", "name": "dscc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22664", "map_id": "Q22664", "name": "ctf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011915", "map_id": "WBGene00011915", "name": "ctf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598178", "map_id": "O44175", "name": "rfc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10598168", "map_id": "P53016", "name": "rfc-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10598173", "map_id": "Q18547", "name": "rfc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10598163", "map_id": "P34429", "name": "RFC5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608181", "map_id": "none", "name": "CTF18-RFC(7s) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10665732", "map_id": "none", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608167", "map_id": "Q21350", "name": "ctf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608177", "map_id": "O44992", "name": "dscc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608172", "map_id": "Q22664", "name": "ctf-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10647775", "map_id": "none", "name": "MRN complex binds CDK2 and RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647771", "map_id": "none", "name": "RBBP8 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q18606", "map_id": "Q18606", "name": "com-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008082", "map_id": "WBGene00008082", "name": "com-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10647773", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648902", "map_id": "none", "name": "Initial resection of double-strand break ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648899", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648080", "map_id": "none", "name": "3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647796", "map_id": "none", "name": "ATM phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10647783", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10647793", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10647786", "map_id": "none", "name": "CDK2 phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10648089", "map_id": "none", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648082", "map_id": "none", "name": "3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O18017", "map_id": "O18017", "name": "him-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001865", "map_id": "WBGene00001865", "name": "him-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91399", "map_id": "P91399", "name": "rmh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019712", "map_id": "WBGene00019712", "name": "rmh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61660", "map_id": "O61660", "name": "top-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006596", "map_id": "WBGene00006596", "name": "top-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19546", "map_id": "Q19546", "name": "wrn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006944", "map_id": "WBGene00006944", "name": "wrn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62217", "map_id": "O62217", "name": "phospho-dog-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001049", "map_id": "WBGene00001049", "name": "phospho-dog-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648086", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648084", "map_id": "none", "name": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648026", "map_id": "none", "name": "EXO1,DNA2:BLM,WRN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648033", "map_id": "O62217", "name": "phospho-dog-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10648074", "map_id": "none", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648066", "map_id": "none", "name": "Ac-K432,K526,K604-RBBP8 homotetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648071", "map_id": "Q95Q89", "name": "sir-2.4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004803", "map_id": "WBGene00004803", "name": "sir-2.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605272", "map_id": "none", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605124", "map_id": "Q9TZ93", "name": "spt-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605282", "map_id": "none", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605254", "map_id": "none", "name": "Paused processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605274", "map_id": "none", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605173", "map_id": "Q9BKS1", "name": "elc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605178", "map_id": "G5ECR7", "name": "elb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605180", "map_id": "none", "name": "Elongin B:C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605280", "map_id": "none", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605245", "map_id": "none", "name": "DSIF:NELF:early elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602932", "map_id": "none", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602930", "map_id": "none", "name": "Pol II Promoter Escape Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110068", "map_id": "none", "name": "DNA containing Pol II promoter with transcript with 2 or 3 nucleotides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605286", "map_id": "none", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10602944", "map_id": "none", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10605268", "map_id": "none", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605161", "map_id": "P41848", "name": "hmg-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605166", "map_id": "Q9N5R9", "name": "spt-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605288", "map_id": "none", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10602069", "map_id": "none", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109877", "map_id": "none", "name": "template DNA with first transcript dinucleotide, opened to +8 position", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605276", "map_id": "none", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605185", "map_id": "Q09413", "name": "tceb-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603082", "map_id": "none", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603080", "map_id": "none", "name": "pol II transcription complex containing 4-9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_75897", "map_id": "none", "name": "template DNA:4-9 nucleotide transcript hybrid", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605270", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605107", "map_id": "none", "name": "CCNT1,CCNT2,CCNK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605093", "map_id": "Q9TVL3", "name": "cdk-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605109", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605256", "map_id": "none", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10605260", "map_id": "none", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605258", "map_id": "none", "name": "Aborted elongation complex after arrest", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10614605", "map_id": "none", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_194236", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10614602", "map_id": "Q21515", "name": "LCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10613943", "map_id": "none", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10613940", "map_id": "none", "name": "Voltage Gated Ca2+ Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01661", "map_id": "O01661", "name": "ccb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000368", "map_id": "WBGene00000368", "name": "ccb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34374", "map_id": "P34374", "name": "unc-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006772", "map_id": "WBGene00006772", "name": "unc-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1E663", "map_id": "A0A3B1E663", "name": "unc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006742", "map_id": "WBGene00006742", "name": "unc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG74", "map_id": "G5EG74", "name": "tag-180", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007041", "map_id": "WBGene00007041", "name": "tag-180", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A078BQJ0", "map_id": "A0A078BQJ0", "name": "ccb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021125", "map_id": "WBGene00021125", "name": "ccb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDT2", "map_id": "G5EDT2", "name": "stg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007670", "map_id": "WBGene00007670", "name": "stg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBI8", "map_id": "G5EBI8", "name": "stg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017400", "map_id": "WBGene00017400", "name": "stg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658294", "map_id": "none", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10658288", "map_id": "Q5CZ37", "name": "fitm-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00044094", "map_id": "WBGene00044094", "name": "fitm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658292", "map_id": "none", "name": "(FITM1,FITM2):TAGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q5CZ37", "map_id": "Q5CZ37", "name": "fitm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658322", "map_id": "none", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866926", "map_id": "none", "name": "lipid droplet", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10658320", "map_id": "none", "name": "HSD17B13:lipid droplet", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10634349", "map_id": "none", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1650779", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10634342", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20679", "map_id": "Q20679", "name": "let-268", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002497", "map_id": "WBGene00002497", "name": "let-268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634346", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10634340", "map_id": "none", "name": "PLOD1:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10634558", "map_id": "none", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10634519", "map_id": "none", "name": "Procollagen type XXVII -N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10634551", "map_id": "none", "name": "Procollagen C-proteinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O61901", "map_id": "O61901", "name": "PCOLCE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020954", "map_id": "WBGene00020954", "name": "PCOLCE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634556", "map_id": "none", "name": "PCOLCEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10634538", "map_id": "none", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10634443", "map_id": "none", "name": "Procollagen type XXVII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10634535", "map_id": "none", "name": "Procollagen N-proteinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10634367", "map_id": "none", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10634360", "map_id": "none", "name": "COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q18989", "map_id": "Q18989", "name": "COLGALT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008426", "map_id": "WBGene00008426", "name": "COLGALT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10634364", "map_id": "none", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10606608", "map_id": "none", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606604", "map_id": "P41846", "name": "phospho-mml-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003378", "map_id": "WBGene00003378", "name": "mml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606606", "map_id": "P41846", "name": "phospho-mml-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606694", "map_id": "none", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10665614", "map_id": "none", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9661418", "map_id": "CHEBI:16990", "name": "BIL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10614140", "map_id": "none", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614137", "map_id": "none", "name": "Astrocytic EAATs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10598798", "map_id": "none", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598795", "map_id": "none", "name": "GLUL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVU2", "map_id": "Q9XVU2", "name": "gln-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001606", "map_id": "WBGene00001606", "name": "gln-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34497", "map_id": "P34497", "name": "gln-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001603", "map_id": "WBGene00001603", "name": "gln-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U307", "map_id": "Q9U307", "name": "gln-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001604", "map_id": "WBGene00001604", "name": "gln-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YD1", "map_id": "Q95YD1", "name": "gln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001602", "map_id": "WBGene00001602", "name": "gln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02225", "map_id": "O02225", "name": "gln-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001607", "map_id": "WBGene00001607", "name": "gln-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636583", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9731226", "map_id": "CHEBI:71362", "name": "8-oxo-dADP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9731235", "map_id": "CHEBI:71361", "name": "8-oxo-dAMP(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636574", "map_id": "O45830", "name": "ndx-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003578", "map_id": "WBGene00003578", "name": "ndx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636540", "map_id": "none", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131972", "map_id": "CHEBI:57967", "name": "ADP-D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636537", "map_id": "none", "name": "NUDT5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61902", "map_id": "O61902", "name": "ndx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003579", "map_id": "WBGene00003579", "name": "ndx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636577", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9731304", "map_id": "CHEBI:143554", "name": "8-oxo-GDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9731298", "map_id": "CHEBI:145694", "name": "8-oxo-GMP(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636580", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9731300", "map_id": "CHEBI:63715", "name": "8-oxo-dGDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9731296", "map_id": "CHEBI:63224", "name": "8-oxo-dGMP(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10636550", "map_id": "none", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2393945", "map_id": "CHEBI:57967", "name": "ADP-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2393950", "map_id": "CHEBI:78346", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10636547", "map_id": "none", "name": "NUDT9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q09297", "map_id": "Q09297", "name": "ndx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003583", "map_id": "WBGene00003583", "name": "ndx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625790", "map_id": "none", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625786", "map_id": "none", "name": "ESCRT-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18258", "map_id": "Q18258", "name": "vps-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016167", "map_id": "WBGene00016167", "name": "vps-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19519", "map_id": "Q19519", "name": "vps-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008919", "map_id": "WBGene00008919", "name": "vps-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U354", "map_id": "Q9U354", "name": "vps-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012193", "map_id": "WBGene00012193", "name": "vps-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625769", "map_id": "none", "name": "ESCRT-I/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9NA26", "map_id": "Q9NA26", "name": "vps-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013598", "map_id": "WBGene00013598", "name": "vps-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44158", "map_id": "O44158", "name": "vps-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016990", "map_id": "WBGene00016990", "name": "vps-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17687", "map_id": "Q17687", "name": "mvb-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015508", "map_id": "WBGene00015508", "name": "mvb-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76258", "map_id": "O76258", "name": "tsg-101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015658", "map_id": "WBGene00015658", "name": "tsg-101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WTK0", "map_id": "Q8WTK0", "name": "spe-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021771", "map_id": "WBGene00021771", "name": "spe-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4R133", "map_id": "Q4R133", "name": "VPS37A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044542", "map_id": "WBGene00044542", "name": "VPS37A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625788", "map_id": "none", "name": "ESCRT-II/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10625767", "map_id": "none", "name": "ESCRT-I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10625798", "map_id": "none", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625796", "map_id": "none", "name": "ESCRT-0/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10625794", "map_id": "none", "name": "ESCRT-0", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625792", "map_id": "none", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625727", "map_id": "none", "name": "ESCRT-III/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10617081", "map_id": "none", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10617006", "map_id": "none", "name": "Docked dopamine loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10643190", "map_id": "none", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617022", "map_id": "A5PEX5", "name": "lin-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10617012", "map_id": "O17583", "name": "lin-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002999", "map_id": "WBGene00002999", "name": "lin-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617028", "map_id": "none", "name": "LIN7:CASK:APBA1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17583", "map_id": "O17583", "name": "lin-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615848", "map_id": "none", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10615843", "map_id": "none", "name": "Docked Noradrenalin loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10655657", "map_id": "none", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6803725", "map_id": "none", "name": "NAEs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:71464", "map_id": "CHEBI:71464", "name": "CHEBI:71464", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85262", "map_id": "CHEBI:85262", "name": "CHEBI:85262", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:71466", "map_id": "CHEBI:71466", "name": "CHEBI:71466", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85263", "map_id": "CHEBI:85263", "name": "CHEBI:85263", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85299", "map_id": "CHEBI:85299", "name": "CHEBI:85299", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693752", "map_id": "CHEBI:2700", "name": "AEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_6803745", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6803778", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10655654", "map_id": "none", "name": "NAAA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9GUI1", "map_id": "Q9GUI1", "name": "NAAA (126-349)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021917", "map_id": "WBGene00021917", "name": "NAAA (126-349)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615853", "map_id": "none", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615841", "map_id": "none", "name": "Noradrenalin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10617030", "map_id": "none", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616993", "map_id": "none", "name": "Dopamine loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "reaction_10615379", "map_id": "none", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_351601", "map_id": "CHEBI:18243", "name": "DA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "false" }, { "id": "reaction_10654711", "map_id": "none", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6799577", "map_id": "CHEBI:91279", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10654708", "map_id": "none", "name": "MAN2B2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10657921", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10657918", "map_id": "Q93324", "name": "MANBA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10657916", "map_id": "none", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10657913", "map_id": "none", "name": "MAN2B1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10646383", "map_id": "none", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646374", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A0K3AUS7", "map_id": "A0A0K3AUS7", "name": "rev-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021344", "map_id": "WBGene00021344", "name": "rev-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646380", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10599229", "map_id": "none", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71019", "map_id": "CHEBI:15466", "name": "MEMA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599226", "map_id": "G5EEG4", "name": "mce-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00008415", "map_id": "WBGene00008415", "name": "mce-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620180", "map_id": "none", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_428248", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10620177", "map_id": "O45145", "name": "ACER2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00020947", "map_id": "WBGene00020947", "name": "ACER2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636098", "map_id": "none", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142811", "map_id": "CHEBI:15626", "name": "12S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142678", "map_id": "CHEBI:34146", "name": "12S-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636093", "map_id": "none", "name": "GPX1/2/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8WFK6", "map_id": "A8WFK6", "name": "gpx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604164", "map_id": "none", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500088", "map_id": "none", "name": "(d)AMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109386", "map_id": "CHEBI:58245", "name": "2'-deoxyadenosine 5'-monophosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10604161", "map_id": "none", "name": "ADK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93934", "map_id": "Q93934", "name": "adk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011128", "map_id": "WBGene00011128", "name": "adk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604092", "map_id": "none", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109986", "map_id": "CHEBI:29140", "name": "4-cis-decenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_109990", "map_id": "CHEBI:29119", "name": "2-trans-4-cis-decadienoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10603984", "map_id": "none", "name": "ACADM tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22347", "map_id": "Q22347", "name": "acdh-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020366", "map_id": "WBGene00020366", "name": "acdh-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604812", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866401", "map_id": "CHEBI:57930", "name": "NDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10604790", "map_id": "Q9N456", "name": "glrx-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021331", "map_id": "WBGene00021331", "name": "glrx-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604793", "map_id": "Q9N456", "name": "glrx-10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8866399", "map_id": "CHEBI:73316", "name": "dNDP(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10604809", "map_id": "none", "name": "RNR (M1M2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q03604", "map_id": "Q03604", "name": "rnr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004391", "map_id": "WBGene00004391", "name": "rnr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42170", "map_id": "P42170", "name": "rnr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004392", "map_id": "WBGene00004392", "name": "rnr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110644", "map_id": "CHEBI:61404", "name": "dATP", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617876", "map_id": "none", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10617873", "map_id": "Q9TZL9", "name": "fard-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00022200", "map_id": "WBGene00022200", "name": "fard-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651381", "map_id": "none", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6797923", "map_id": "CHEBI:17724", "name": "DMGLY", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6797920", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6797917", "map_id": "CHEBI:15611", "name": "SARC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10651378", "map_id": "none", "name": "DMGDH:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A486WWC6", "map_id": "A0A486WWC6", "name": "DMGDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021355", "map_id": "WBGene00021355", "name": "DMGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665635", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665629", "map_id": "none", "name": "GSTA1, FABP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10665631", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601956", "map_id": "none", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73917", "map_id": "CHEBI:15467", "name": "HMG CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10601953", "map_id": "P54871", "name": "hmgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10601613", "map_id": "none", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601610", "map_id": "none", "name": "PRPS1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6AHR3", "map_id": "Q6AHR3", "name": "PRPS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020107", "map_id": "WBGene00020107", "name": "PRPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633842", "map_id": "none", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1861764", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194377", "map_id": "CHEBI:52639", "name": "N-acylsphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633839", "map_id": "none", "name": "Homologues of GBA3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TZA0", "map_id": "Q9TZA0", "name": "klo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017103", "map_id": "WBGene00017103", "name": "klo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18758", "map_id": "Q18758", "name": "klo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016848", "map_id": "WBGene00016848", "name": "klo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599441", "map_id": "none", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31311", "map_id": "CHEBI:18020", "name": "TEABL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31369", "map_id": "CHEBI:16244", "name": "TEABT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599438", "map_id": "none", "name": "ALDH9A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20352", "map_id": "Q20352", "name": "alh-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000117", "map_id": "WBGene00000117", "name": "alh-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602155", "map_id": "none", "name": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500259", "map_id": "none", "name": "Gua, Hyp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500260", "map_id": "none", "name": "GMP, IMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10614847", "map_id": "none", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614844", "map_id": "none", "name": "GGT1, 5 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609829", "map_id": "none", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189487", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10609826", "map_id": "none", "name": "2x(FECH:2Fe-2S cluster)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5EBW5", "map_id": "G5EBW5", "name": "fecl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010645", "map_id": "WBGene00010645", "name": "fecl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391232", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10648965", "map_id": "none", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693754", "map_id": "CHEBI:2700", "name": "AEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648962", "map_id": "Q9U2I8", "name": "faah-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00012750", "map_id": "WBGene00012750", "name": "faah-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613738", "map_id": "none", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613735", "map_id": "none", "name": "Homologues of PNMT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34254", "map_id": "P34254", "name": "anmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20308", "map_id": "Q20308", "name": "anmt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018340", "map_id": "WBGene00018340", "name": "anmt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22279", "map_id": "Q22279", "name": "anmt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011573", "map_id": "WBGene00011573", "name": "anmt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603959", "map_id": "none", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77302", "map_id": "CHEBI:15491", "name": "3-Oxopalmitoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77272", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10623581", "map_id": "none", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_482627", "map_id": "none", "name": "(d)NDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:60471", "map_id": "CHEBI:60471", "name": "CHEBI:60471", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58369", "map_id": "CHEBI:58369", "name": "CHEBI:58369", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58595", "map_id": "CHEBI:58595", "name": "CHEBI:58595", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:57667", "map_id": "CHEBI:57667", "name": "CHEBI:57667", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58069", "map_id": "CHEBI:58069", "name": "CHEBI:58069", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58593", "map_id": "CHEBI:58593", "name": "CHEBI:58593", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_482625", "map_id": "none", "name": "(d)NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500739", "map_id": "CHEBI:61555", "name": "dUTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10623578", "map_id": "none", "name": "NME1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602160", "map_id": "none", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500087", "map_id": "none", "name": "(d)ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602157", "map_id": "none", "name": "Adenylate Kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20230", "map_id": "Q20230", "name": "CMPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009575", "map_id": "WBGene00009575", "name": "CMPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20140", "map_id": "Q20140", "name": "AK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009531", "map_id": "WBGene00009531", "name": "AK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614546", "map_id": "none", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_217320", "map_id": "CHEBI:63828", "name": "MTZ-SOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614543", "map_id": "none", "name": "FMO2:FAD:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EDG8", "map_id": "G5EDG8", "name": "fmo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001479", "map_id": "WBGene00001479", "name": "fmo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP6", "map_id": "G5EDP6", "name": "fmo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001476", "map_id": "WBGene00001476", "name": "fmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED43", "map_id": "G5ED43", "name": "fmo-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001480", "map_id": "WBGene00001480", "name": "fmo-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECJ8", "map_id": "G5ECJ8", "name": "fmo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001478", "map_id": "WBGene00001478", "name": "fmo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBJ9", "map_id": "G5EBJ9", "name": "fmo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001477", "map_id": "WBGene00001477", "name": "fmo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638233", "map_id": "none", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995348", "map_id": "CHEBI:24479", "name": "heme A", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10638230", "map_id": "Q22251", "name": "cox-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011526", "map_id": "WBGene00011526", "name": "cox-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603995", "map_id": "none", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10643274", "map_id": "none", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5340315", "map_id": "CHEBI:24402", "name": "GSL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5340299", "map_id": "CHEBI:24402", "name": "GSL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10643271", "map_id": "Q9BKS2", "name": "GLTP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10630841", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10630834", "map_id": "none", "name": "CA1,2,3,7,13:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664496", "map_id": "none", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605593", "map_id": "CHEBI:140911", "name": "LeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605586", "map_id": "CHEBI:140912", "name": "LeY", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10664676", "map_id": "none", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9604808", "map_id": "CHEBI:140876", "name": "GlcNAc-\u00ce\u00b21,3-Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10664673", "map_id": "none", "name": "B3GALTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95US5", "map_id": "Q95US5", "name": "bre-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000270", "map_id": "WBGene00000270", "name": "bre-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62115", "map_id": "O62115", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011780", "map_id": "WBGene00011780", "name": "B3GALT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0F4", "map_id": "H2L0F4", "name": "bus-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044618", "map_id": "WBGene00044618", "name": "bus-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECA6", "map_id": "G5ECA6", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17750", "map_id": "O17750", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU74", "map_id": "Q9XU74", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02310", "map_id": "O02310", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6QMT2", "map_id": "Q6QMT2", "name": "bre-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000267", "map_id": "WBGene00000267", "name": "bre-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62165", "map_id": "O62165", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62375", "map_id": "O62375", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB3", "map_id": "G5EDB3", "name": "bus-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044630", "map_id": "WBGene00044630", "name": "bus-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62163", "map_id": "O62163", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02231", "map_id": "O02231", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62114", "map_id": "O62114", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQG4", "map_id": "Q8MQG4", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660515", "map_id": "none", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8879102", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8879101", "map_id": "CHEBI:18259", "name": "Gb4Cer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10660512", "map_id": "Q6QMT2", "name": "bre-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10635654", "map_id": "none", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10632925", "map_id": "Q9XX00", "name": "sbp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10632931", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XX00", "map_id": "Q9XX00", "name": "sbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606792", "map_id": "none", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10606782", "map_id": "none", "name": "ATPase:ADP:Pi", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10658283", "map_id": "none", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8857646", "map_id": "CHEBI:37739", "name": "GPL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_8857684", "map_id": "CHEBI:37739", "name": "GPL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10658280", "map_id": "none", "name": "ESYT1:ESYT2:ESYT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10633575", "map_id": "none", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023968", "map_id": "none", "name": "(PP)2-IP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:62924", "map_id": "CHEBI:62924", "name": "CHEBI:62924", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1629732", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1629765", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633572", "map_id": "none", "name": "NUDT(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95XC4", "map_id": "Q95XC4", "name": "NUDT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022366", "map_id": "WBGene00022366", "name": "NUDT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620259", "map_id": "none", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620256", "map_id": "Q9Y194", "name": "spl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00004981", "map_id": "WBGene00004981", "name": "spl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635604", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10649513", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10649510", "map_id": "none", "name": "Homologues of AWAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10601689", "map_id": "none", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73617", "map_id": "CHEBI:74414", "name": "UIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73619", "map_id": "CHEBI:57731", "name": "3AIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601640", "map_id": "none", "name": "UPB1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19437", "map_id": "Q19437", "name": "upb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017440", "map_id": "WBGene00017440", "name": "upb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633672", "map_id": "none", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633513", "map_id": "none", "name": "IMPA1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19420", "map_id": "Q19420", "name": "ttx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008765", "map_id": "WBGene00008765", "name": "ttx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602203", "map_id": "none", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30064", "map_id": "CHEBI:17712", "name": "XAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604102", "map_id": "none", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109994", "map_id": "CHEBI:29126", "name": "3-trans-decenoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10604099", "map_id": "none", "name": "DECR1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23116", "map_id": "Q23116", "name": "decr-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012177", "map_id": "WBGene00012177", "name": "decr-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602864", "map_id": "none", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109378", "map_id": "CHEBI:57566", "name": "dCMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10601577", "map_id": "none", "name": "CMPK1, AK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662674", "map_id": "none", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955853", "map_id": "CHEBI:47013", "name": "D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10662671", "map_id": "Q19133", "name": "RBKS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008548", "map_id": "WBGene00008548", "name": "RBKS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601633", "map_id": "none", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73584", "map_id": "CHEBI:15901", "name": "5,6-Dihydrouracil", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73588", "map_id": "CHEBI:11892", "name": "UPROP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601630", "map_id": "none", "name": "DPYS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599656", "map_id": "none", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599579", "map_id": "none", "name": "PGYM dimer, b form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N5U1", "map_id": "Q9N5U1", "name": "phospho-pygl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020696", "map_id": "WBGene00020696", "name": "phospho-pygl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599584", "map_id": "none", "name": "PGYM dimer a form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599653", "map_id": "none", "name": "phosphorylase kinase complex (PHKM)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34335", "map_id": "P34335", "name": "PHKA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015754", "map_id": "WBGene00015754", "name": "PHKA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0I6", "map_id": "H2L0I6", "name": "PHKB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022059", "map_id": "WBGene00022059", "name": "PHKB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3L4", "map_id": "Q9N3L4", "name": "PHKG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021753", "map_id": "WBGene00021753", "name": "PHKG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598455", "map_id": "none", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29452", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598452", "map_id": "none", "name": "GALE:NAD+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q564Q1", "map_id": "Q564Q1", "name": "gale-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008132", "map_id": "WBGene00008132", "name": "gale-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649967", "map_id": "none", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784236", "map_id": "CHEBI:32812", "name": "4-OH-L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598751", "map_id": "none", "name": "GOT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q17994", "map_id": "Q17994", "name": "got-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015778", "map_id": "WBGene00015778", "name": "got-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648292", "map_id": "none", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5689006", "map_id": "CHEBI:8050", "name": "PHEN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5688995", "map_id": "CHEBI:85505", "name": "4-ethoxyaniline", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5689001", "map_id": "CHEBI:40574", "name": "acetyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648289", "map_id": "Q7JMM5", "name": "AADAC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00017515", "map_id": "WBGene00017515", "name": "NCEH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620296", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620293", "map_id": "none", "name": "PPAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q10022", "map_id": "Q10022", "name": "plpp-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020895", "map_id": "WBGene00020895", "name": "plpp-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19403", "map_id": "Q19403", "name": "plpp-1.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008749", "map_id": "WBGene00008749", "name": "plpp-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZD1", "map_id": "H2KZD1", "name": "plpp-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018756", "map_id": "WBGene00018756", "name": "plpp-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617789", "map_id": "none", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389822", "map_id": "CHEBI:29805", "name": "glycolate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389678", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617786", "map_id": "none", "name": "HAO1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10633115", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10633112", "map_id": "none", "name": "PI4KA/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599096", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599093", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P46562", "map_id": "P46562", "name": "alh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000115", "map_id": "WBGene00000115", "name": "alh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633675", "map_id": "none", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629753", "map_id": "CHEBI:18384", "name": "I4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10610954", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610951", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9UAV5", "map_id": "Q9UAV5", "name": "mdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018491", "map_id": "WBGene00018491", "name": "mdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602188", "map_id": "none", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10663917", "map_id": "none", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9014643", "map_id": "CHEBI:58020", "name": "2AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10663914", "map_id": "Q10121", "name": "Q10121", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016011", "map_id": "WBGene00016011", "name": "Q10121", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637076", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:61314", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10637070", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GYG4", "map_id": "Q9GYG4", "name": "hap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001823", "map_id": "WBGene00001823", "name": "hap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632691", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_1606283", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1606280", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10632688", "map_id": "none", "name": "SMPD4:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q95ZR2", "map_id": "Q95ZR2", "name": "SMPD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011037", "map_id": "WBGene00011037", "name": "SMPD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650255", "map_id": "none", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598398", "map_id": "none", "name": "PGM2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657188", "map_id": "none", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2239407", "map_id": "CHEBI:60479", "name": "lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_6814794", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10657185", "map_id": "Q17540", "name": "ENPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10636091", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10665955", "map_id": "none", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10665952", "map_id": "none", "name": "Homologues of SPNS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01927", "map_id": "O01927", "name": "spin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007549", "map_id": "WBGene00007549", "name": "spin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1DV80", "map_id": "A0A3B1DV80", "name": "spin-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013739", "map_id": "WBGene00013739", "name": "spin-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19235", "map_id": "Q19235", "name": "spin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008598", "map_id": "WBGene00008598", "name": "spin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18545", "map_id": "Q18545", "name": "spin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008033", "map_id": "WBGene00008033", "name": "spin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649446", "map_id": "none", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428663", "map_id": "CHEBI:17600", "name": "HXAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649443", "map_id": "none", "name": "Homologues of ALDH3B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10649074", "map_id": "none", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10649053", "map_id": "none", "name": "GCSH:SAMDLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:14949", "map_id": "CHEBI:14949", "name": "CHEBI:14949", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20634", "map_id": "Q20634", "name": "gcsh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009918", "map_id": "WBGene00009918", "name": "gcsh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649066", "map_id": "none", "name": "GCSH:DHLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:50746", "map_id": "CHEBI:50746", "name": "CHEBI:50746", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649071", "map_id": "Q22968", "name": "gcst-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00017765", "map_id": "WBGene00017765", "name": "gcst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650376", "map_id": "none", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6788813", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6788807", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10650373", "map_id": "Q09527", "name": "AK6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00008458", "map_id": "WBGene00008458", "name": "AK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599073", "map_id": "none", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34979", "map_id": "CHEBI:27384", "name": "4I-5PROA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30158", "map_id": "CHEBI:18327", "name": "NF-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599070", "map_id": "Q22419", "name": "AMDHD1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020436", "map_id": "WBGene00020436", "name": "AMDHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604569", "map_id": "none", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604566", "map_id": "P34346", "name": "let-754", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "WBGene00002879", "map_id": "WBGene00002879", "name": "let-754", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665633", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10614855", "map_id": "none", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266066", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632904", "map_id": "none", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_744227", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1660674", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10632901", "map_id": "G5EC84", "name": "cgt-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00017625", "map_id": "WBGene00017625", "name": "cgt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658932", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8866574", "map_id": "CHEBI:61560", "name": "dNTP(4-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866608", "map_id": "CHEBI:18274", "name": "2'-deoxynucleoside", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866567", "map_id": "CHEBI:18036", "name": "PPPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_9668967", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10658929", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09374", "map_id": "Q09374", "name": "SAMHD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022673", "map_id": "WBGene00022673", "name": "SAMHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648973", "map_id": "none", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_5693747", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693733", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693736", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10648970", "map_id": "Q9NAB7", "name": "FAAH2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "WBGene00013164", "map_id": "WBGene00013164", "name": "FAAH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598743", "map_id": "none", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598728", "map_id": "none", "name": "PXLP-K259-GOT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22067", "map_id": "Q22067", "name": "got-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020146", "map_id": "WBGene00020146", "name": "got-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625839", "map_id": "none", "name": "FLVCR1-1 transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10625836", "map_id": "O01735", "name": "FLVCR1-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00015632", "map_id": "WBGene00015632", "name": "FLVCR1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633276", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10633273", "map_id": "Q93641", "name": "sac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10620499", "map_id": "none", "name": "PRKD1,2,3 phosphorylates CERT1-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620471", "map_id": "Q93569", "name": "CERT1-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009120", "map_id": "WBGene00009120", "name": "phospho-p-S,S132,T-CERT1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620474", "map_id": "Q93569", "name": "phospho-p-S132-CERT1-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620496", "map_id": "none", "name": "PRKD1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45818", "map_id": "O45818", "name": "dkf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012019", "map_id": "WBGene00012019", "name": "dkf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUJ7", "map_id": "Q9XUJ7", "name": "dkf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012352", "map_id": "WBGene00012352", "name": "dkf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625298", "map_id": "none", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10625295", "map_id": "none", "name": "AGXT2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02158", "map_id": "O02158", "name": "PXLP-AGXT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020382", "map_id": "WBGene00020382", "name": "PXLP-AGXT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646515", "map_id": "none", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668573", "map_id": "CHEBI:29191", "name": "hydroxyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668567", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668577", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662695", "map_id": "CHEBI:16852", "name": "L-Dopaquinone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10646512", "map_id": "none", "name": "TYR:2xCu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "P34269", "map_id": "P34269", "name": "tyr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015332", "map_id": "WBGene00015332", "name": "tyr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602200", "map_id": "none", "name": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500245", "map_id": "none", "name": "G, dG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602175", "map_id": "none", "name": "PNP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598754", "map_id": "none", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10656850", "map_id": "none", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30393", "map_id": "CHEBI:17378", "name": "GA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799497", "map_id": "CHEBI:32398", "name": "DGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599768", "map_id": "none", "name": "ALDH1A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10613758", "map_id": "none", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10649405", "map_id": "none", "name": "ACAD10 dehydrogenates S-2MPDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5695946", "map_id": "CHEBI:85944", "name": "S-2MPDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5695949", "map_id": "CHEBI:85945", "name": "S-2MDPDA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649402", "map_id": "O01590", "name": "acds-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00019599", "map_id": "WBGene00019599", "name": "acds-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648981", "map_id": "none", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693768", "map_id": "CHEBI:85781", "name": "2HCERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10648978", "map_id": "Q9XVS0", "name": "fath-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007707", "map_id": "WBGene00007707", "name": "fath-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603973", "map_id": "none", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77328", "map_id": "CHEBI:28264", "name": "3-Oxooctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77326", "map_id": "CHEBI:27540", "name": "HX-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10620208", "map_id": "none", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_9025544", "map_id": "CHEBI:31998", "name": "N-acylphytosphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10620202", "map_id": "none", "name": "Homologues of DEGS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10637073", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:61402", "name": "ITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615384", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_372364", "map_id": "CHEBI:58702", "name": "PEP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10615381", "map_id": "O02286", "name": "pck-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00011232", "map_id": "WBGene00011232", "name": "pck-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598437", "map_id": "none", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598434", "map_id": "none", "name": "TKFC:2Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N5C4", "map_id": "Q9N5C4", "name": "TKFC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020962", "map_id": "WBGene00020962", "name": "TKFC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602986", "map_id": "none", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390404", "map_id": "CHEBI:57642", "name": "DHAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390426", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390419", "map_id": "CHEBI:17868", "name": "1-Palmitoyl dihydroxyacetone phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10602983", "map_id": "none", "name": "GNPAT:AGPS complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O45218", "map_id": "O45218", "name": "ads-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000081", "map_id": "WBGene00000081", "name": "ads-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601687", "map_id": "none", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73541", "map_id": "CHEBI:27468", "name": "5,6-Dihydrothymine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10613721", "map_id": "none", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_351595", "map_id": "CHEBI:38290", "name": "AscH-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351593", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351603", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351597", "map_id": "CHEBI:18357", "name": "NAd", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351599", "map_id": "CHEBI:58539", "name": "DeHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10613718", "map_id": "none", "name": "DBH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "Q9XTQ6", "map_id": "Q9XTQ6", "name": "tbh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006541", "map_id": "WBGene00006541", "name": "tbh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18315", "map_id": "CHEBI:18315", "name": "CHEBI:18315", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598445", "map_id": "none", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30170", "map_id": "CHEBI:17973", "name": "Gal1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598442", "map_id": "Q27536", "name": "GALT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00014203", "map_id": "WBGene00014203", "name": "GALT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599677", "map_id": "none", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599664", "map_id": "none", "name": "limit dextrin-glycogenin-2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599669", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599674", "map_id": "O62334", "name": "agl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632966", "map_id": "none", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10632960", "map_id": "Q9XX00", "name": "sbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10656397", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10656388", "map_id": "none", "name": "MTM1:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "V6CJW9", "map_id": "V6CJW9", "name": "MTMR12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021683", "map_id": "WBGene00021683", "name": "MTMR12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646163", "map_id": "none", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10646160", "map_id": "none", "name": "SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10613668", "map_id": "none", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352030", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351630", "map_id": "CHEBI:17606", "name": "I2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_622410", "map_id": "CHEBI:43451", "name": "HI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351639", "map_id": "CHEBI:27847", "name": "MIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10613665", "map_id": "none", "name": "Homologues of TPO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10598667", "map_id": "none", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10598664", "map_id": "none", "name": "pyruvate carboxylase holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10603955", "map_id": "none", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77284", "map_id": "CHEBI:28935", "name": "trans-Hexadec-2-enoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77300", "map_id": "CHEBI:27402", "name": "(S)-3-Hydroxyhexadecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10648947", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10636081", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10636078", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "H2KYS3", "map_id": "H2KYS3", "name": "daf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620190", "map_id": "none", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428198", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_428193", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10620187", "map_id": "O45145", "name": "ACER1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598847", "map_id": "none", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598844", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18040", "map_id": "Q18040", "name": "oatr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015814", "map_id": "WBGene00015814", "name": "oatr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10631244", "map_id": "none", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601643", "map_id": "none", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10633758", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994141", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629755", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10633552", "map_id": "none", "name": "IP6K1/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662836", "map_id": "none", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959518", "map_id": "CHEBI:16144", "name": "SELP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10662833", "map_id": "O62461", "name": "seld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012867", "map_id": "WBGene00012867", "name": "seld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633620", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633617", "map_id": "Q9XXI1", "name": "ippk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10603977", "map_id": "none", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77332", "map_id": "CHEBI:27537", "name": "trans-Oct-2-enoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77330", "map_id": "CHEBI:28632", "name": "(S)-Hydroxyoctanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10657668", "map_id": "none", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8936165", "map_id": "none", "name": "ADP,GDP,CDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8851369", "map_id": "none", "name": "AMP,GMP,CMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10657665", "map_id": "none", "name": "NPTDase5:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9XU84", "map_id": "Q9XU84", "name": "uda-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010697", "map_id": "WBGene00010697", "name": "uda-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599797", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599794", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623690", "map_id": "none", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_482807", "map_id": "none", "name": "(d)NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_482803", "map_id": "none", "name": "(d)NDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10623685", "map_id": "none", "name": "NME4 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10617879", "map_id": "none", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390440", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390409", "map_id": "CHEBI:17197", "name": "GO3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10660679", "map_id": "none", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8932801", "map_id": "CHEBI:132873", "name": "5-HETEL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8932804", "map_id": "CHEBI:60943", "name": "5-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10660676", "map_id": "none", "name": "PON1,2,3:2xCa2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O01811", "map_id": "O01811", "name": "mec-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003170", "map_id": "WBGene00003170", "name": "mec-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966L1", "map_id": "Q966L1", "name": "poml-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017089", "map_id": "WBGene00017089", "name": "poml-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2V071", "map_id": "Q2V071", "name": "poml-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044697", "map_id": "WBGene00044697", "name": "poml-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1V898", "map_id": "B1V898", "name": "poml-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077701", "map_id": "WBGene00077701", "name": "poml-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21427", "map_id": "Q21427", "name": "poml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010775", "map_id": "WBGene00010775", "name": "poml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646108", "map_id": "none", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5652213", "map_id": "CHEBI:17924", "name": "D-sorbitol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10622852", "map_id": "none", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622850", "map_id": "none", "name": "PGYM b dimer:AMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659921", "map_id": "none", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8874749", "map_id": "CHEBI:15489", "name": "3OA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10659918", "map_id": "none", "name": "ACAA2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45552", "map_id": "O45552", "name": "acaa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009952", "map_id": "WBGene00009952", "name": "acaa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606630", "map_id": "none", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602999", "map_id": "Q22267", "name": "acl-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10606617", "map_id": "none", "name": "ChREBP:MLX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TZ70", "map_id": "Q9TZ70", "name": "mxl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003510", "map_id": "WBGene00003510", "name": "mxl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41846", "map_id": "P41846", "name": "mml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632627", "map_id": "none", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605713", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605750", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10632624", "map_id": "Q23498", "name": "asm-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00000212", "map_id": "WBGene00000212", "name": "asm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650017", "map_id": "none", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6784964", "map_id": "CHEBI:35854", "name": "VACV", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10650014", "map_id": "Q9TZ58", "name": "BPHL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00019280", "map_id": "WBGene00019280", "name": "BPHL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632606", "map_id": "none", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605608", "map_id": "CHEBI:61360", "name": "Globoside", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605716", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10632603", "map_id": "none", "name": "HEXA,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10604965", "map_id": "none", "name": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630856", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10630851", "map_id": "none", "name": "CA5A,B:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10620269", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_428662", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10620266", "map_id": "H2KZD1", "name": "plpp-1.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10599499", "map_id": "none", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29732", "map_id": "CHEBI:17363", "name": "RU5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599496", "map_id": "P41994", "name": "rpia-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015101", "map_id": "WBGene00015101", "name": "rpia-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660470", "map_id": "none", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668566", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662670", "map_id": "CHEBI:2003", "name": "DHICA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_8878586", "map_id": "CHEBI:81394", "name": "IQCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668574", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10660467", "map_id": "none", "name": "Homologues of TYRP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "O01497", "map_id": "O01497", "name": "tyr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016419", "map_id": "WBGene00016419", "name": "tyr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS8", "map_id": "Q9XUS8", "name": "tyr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010661", "map_id": "WBGene00010661", "name": "tyr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XC6", "map_id": "Q95XC6", "name": "tyr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022231", "map_id": "WBGene00022231", "name": "tyr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19673", "map_id": "Q19673", "name": "tyr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009001", "map_id": "WBGene00009001", "name": "tyr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76708", "map_id": "O76708", "name": "tyr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021553", "map_id": "WBGene00021553", "name": "tyr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623783", "map_id": "none", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10623780", "map_id": "none", "name": "P5CS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P54889", "map_id": "P54889", "name": "alh-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011938", "map_id": "WBGene00011938", "name": "alh-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633623", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629769", "map_id": "CHEBI:18225", "name": "I(1,3)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10603991", "map_id": "none", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77341", "map_id": "CHEBI:28325", "name": "(S)-Hydroxydecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77339", "map_id": "CHEBI:28528", "name": "3-Oxodecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10633658", "map_id": "none", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10633578", "map_id": "none", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023943", "map_id": "none", "name": "PP-IP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1629736", "map_id": "CHEBI:62926", "name": "1-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:62927", "map_id": "CHEBI:62927", "name": "CHEBI:62927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10633566", "map_id": "none", "name": "NUDT4:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598621", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598618", "map_id": "none", "name": "FBP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBJ7", "map_id": "G5EBJ7", "name": "fbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001404", "map_id": "WBGene00001404", "name": "fbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10635652", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10632943", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10635648", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10632941", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10635650", "map_id": "none", "name": "Importin-beta:Ran GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10620130", "map_id": "none", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428182", "map_id": "CHEBI:17862", "name": "3-ketosphinganine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10620127", "map_id": "U4PBL3", "name": "KDSR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021367", "map_id": "WBGene00021367", "name": "KDSR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602133", "map_id": "none", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10602130", "map_id": "none", "name": "HMGCL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10604815", "map_id": "none", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10598741", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10598738", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23621", "map_id": "Q23621", "name": "gdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633764", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10635606", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10651363", "map_id": "none", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29642", "map_id": "CHEBI:58048", "name": "L-Asn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10651360", "map_id": "Q9U3P0", "name": "ASPG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007756", "map_id": "WBGene00007756", "name": "ASPG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664533", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605607", "map_id": "CHEBI:140878", "name": "LeA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10601948", "map_id": "none", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10601673", "map_id": "none", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_109382", "map_id": "CHEBI:246422", "name": "dUMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10601670", "map_id": "none", "name": "TS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N588", "map_id": "Q9N588", "name": "tyms-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022455", "map_id": "WBGene00022455", "name": "tyms-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599471", "map_id": "none", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599468", "map_id": "none", "name": "PGD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17761", "map_id": "Q17761", "name": "PGD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012015", "map_id": "WBGene00012015", "name": "PGD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649413", "map_id": "none", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10649410", "map_id": "Q9UAV8", "name": "acs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00018488", "map_id": "WBGene00018488", "name": "acs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633309", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10602123", "map_id": "none", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10602120", "map_id": "none", "name": "OXCT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q09450", "map_id": "Q09450", "name": "OXCT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007330", "map_id": "WBGene00007330", "name": "OXCT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615281", "map_id": "none", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113577", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_70951", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10615278", "map_id": "O62347", "name": "slc-25a21", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011226", "map_id": "WBGene00011226", "name": "slc-25a21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604557", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604554", "map_id": "none", "name": "AK5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09629", "map_id": "Q09629", "name": "AK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10637079", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:61382", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9731659", "map_id": "CHEBI:61194", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10666203", "map_id": "none", "name": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9731609", "map_id": "CHEBI:169976", "name": "N(6)-methyl-dAMP(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9731652", "map_id": "CHEBI:59338", "name": "methylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10632609", "map_id": "none", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10632564", "map_id": "O02106", "name": "mlt-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605610", "map_id": "CHEBI:51013", "name": "GM2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10632566", "map_id": "none", "name": "GM2A:GM2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10633583", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10649455", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649452", "map_id": "none", "name": "ALDH1B1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10648824", "map_id": "none", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10648821", "map_id": "none", "name": "ALDH3A2-1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10656394", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633087", "map_id": "Q9N589", "name": "mtm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656386", "map_id": "V6CJW9", "name": "MTMR12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656392", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10603953", "map_id": "none", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10603950", "map_id": "none", "name": "ACADVL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q19057", "map_id": "Q19057", "name": "acdh-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017125", "map_id": "WBGene00017125", "name": "acdh-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660930", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "false" }, { "id": "species_10660927", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598766", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10630854", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10649384", "map_id": "none", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10649381", "map_id": "Q21166", "name": "sur-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006351", "map_id": "WBGene00006351", "name": "sur-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10664694", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605595", "map_id": "CHEBI:140917", "name": "Type 1 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605615", "map_id": "CHEBI:140914", "name": "sLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10598427", "map_id": "none", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31221", "map_id": "CHEBI:18105", "name": "Fru 1-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598424", "map_id": "none", "name": "ALDOB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635656", "map_id": "none", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10632933", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657379", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598731", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10610944", "map_id": "none", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610941", "map_id": "none", "name": "SLC25A11 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P90992", "map_id": "P90992", "name": "misc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015186", "map_id": "WBGene00015186", "name": "misc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646517", "map_id": "none", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5668568", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "reaction_10614529", "map_id": "none", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_159154", "map_id": "CHEBI:41774", "name": "TAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217269", "map_id": "CHEBI:63825", "name": "TAMO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10614526", "map_id": "none", "name": "FMO1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10665612", "map_id": "none", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10655768", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806881", "map_id": "CHEBI:61557", "name": "NTP(4-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10655765", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601685", "map_id": "none", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601620", "map_id": "none", "name": "DPYD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18164", "map_id": "Q18164", "name": "dpyd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016103", "map_id": "WBGene00016103", "name": "dpyd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613756", "map_id": "none", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351627", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351628", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10613753", "map_id": "none", "name": "DEHAL1:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34273", "map_id": "P34273", "name": "sup-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015334", "map_id": "WBGene00015334", "name": "sup-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599279", "map_id": "none", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70955", "map_id": "CHEBI:15524", "name": "GL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71045", "map_id": "CHEBI:15473", "name": "crotonyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599276", "map_id": "none", "name": "GCDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20772", "map_id": "Q20772", "name": "GCDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010052", "map_id": "WBGene00010052", "name": "GCDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632693", "map_id": "none", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605601", "map_id": "CHEBI:17950", "name": "LacCer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605592", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10649944", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649941", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20848", "map_id": "Q20848", "name": "PYCR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018904", "map_id": "WBGene00018904", "name": "PYCR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21544", "map_id": "Q21544", "name": "pycr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010924", "map_id": "WBGene00010924", "name": "pycr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623815", "map_id": "none", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623812", "map_id": "none", "name": "GMPR tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16294", "map_id": "O16294", "name": "GMPR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017984", "map_id": "WBGene00017984", "name": "GMPR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646519", "map_id": "none", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662708", "map_id": "none", "name": "DHI, DHICA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "CHEBI:27404", "map_id": "CHEBI:27404", "name": "CHEBI:27404", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5662678", "map_id": "none", "name": "Eumelanin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "reaction_10630837", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10620211", "map_id": "none", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10656412", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10656404", "map_id": "none", "name": "MTMR2:SBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9TXP3", "map_id": "Q9TXP3", "name": "mtm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003477", "map_id": "WBGene00003477", "name": "mtm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633755", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10633752", "map_id": "none", "name": "INPP5A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q17848", "map_id": "Q17848", "name": "ipp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002146", "map_id": "WBGene00002146", "name": "ipp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647415", "map_id": "none", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5679042", "map_id": "none", "name": "BMG,BDG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16427", "map_id": "CHEBI:16427", "name": "CHEBI:16427", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18392", "map_id": "CHEBI:18392", "name": "CHEBI:18392", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5679034", "map_id": "none", "name": "BMG,BDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10605609", "map_id": "none", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_30373", "map_id": "CHEBI:18139", "name": "TMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140963", "map_id": "CHEBI:15724", "name": "TMAO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10605606", "map_id": "none", "name": "FMO3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10636567", "map_id": "none", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10636563", "map_id": "none", "name": "FDXR:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U1X0", "map_id": "Q9U1X0", "name": "FDXR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013376", "map_id": "WBGene00013376", "name": "FDXR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10630212", "map_id": "none", "name": "FDX2 (oxidized)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA32", "map_id": "Q9NA32", "name": "FDX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013532", "map_id": "WBGene00013532", "name": "FDX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10636565", "map_id": "none", "name": "FDXR:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10630208", "map_id": "none", "name": "FDX2 (reduced)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666187", "map_id": "none", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10614764", "map_id": "none", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614761", "map_id": "none", "name": "Voltage-gated Calcium Channels (pancreatic beta cell)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MQA1", "map_id": "Q8MQA1", "name": "egl-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001187", "map_id": "WBGene00001187", "name": "egl-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601653", "map_id": "none", "name": "dCMP + H2O => dUMP + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601650", "map_id": "none", "name": "DCTD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P30648", "map_id": "P30648", "name": "DCTD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014034", "map_id": "WBGene00014034", "name": "DCTD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615392", "map_id": "none", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10647362", "map_id": "none", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162232", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10647359", "map_id": "none", "name": "MIOX:2xFe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q65CM5", "map_id": "Q65CM5", "name": "MIOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016920", "map_id": "WBGene00016920", "name": "MIOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633327", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10633169", "map_id": "none", "name": "PIK3C2A:Ca2+/Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620557", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429773", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429789", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10620554", "map_id": "Q965Q4", "name": "sms-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00004894", "map_id": "WBGene00004894", "name": "sms-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606787", "map_id": "none", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10606784", "map_id": "none", "name": "ATPase:ATP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10662486", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10662483", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45903", "map_id": "O45903", "name": "MECR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012375", "map_id": "WBGene00012375", "name": "MECR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606790", "map_id": "none", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10599491", "map_id": "none", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599488", "map_id": "none", "name": "RPE:Fe2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95ZW2", "map_id": "Q95ZW2", "name": "RPE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017272", "map_id": "WBGene00017272", "name": "RPE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620185", "map_id": "none", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10651159", "map_id": "none", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10651143", "map_id": "none", "name": "DHs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23629", "map_id": "Q23629", "name": "ogdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014098", "map_id": "WBGene00014098", "name": "ogdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10649049", "map_id": "Q20634", "name": "gcsh-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649051", "map_id": "Q20634", "name": "gcsh-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10651151", "map_id": "none", "name": "lipoylated DHs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10651156", "map_id": "O45303", "name": "lipt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00001590", "map_id": "WBGene00001590", "name": "lipt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620261", "map_id": "none", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10656406", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656402", "map_id": "Q9TXP3", "name": "mtm-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10662852", "map_id": "none", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959707", "map_id": "CHEBI:16802", "name": "Sedo", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10662849", "map_id": "O45814", "name": "shpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012017", "map_id": "WBGene00012017", "name": "shpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657682", "map_id": "none", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen" }, { "id": "species_8851509", "map_id": "none", "name": "CTP,GTP,UTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "species_8851517", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_8851518", "map_id": "none", "name": "CDP,GDP,UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "species_8851513", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_5228597", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_10657679", "map_id": "none", "name": "NTPDase7:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "Q21815", "map_id": "Q21815", "name": "mig-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003254", "map_id": "WBGene00003254", "name": "mig-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630215", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10630201", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45948", "map_id": "O45948", "name": "iscu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012885", "map_id": "WBGene00012885", "name": "iscu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TY03", "map_id": "Q9TY03", "name": "frh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001486", "map_id": "WBGene00001486", "name": "frh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2R8F5A8", "map_id": "A0A2R8F5A8", "name": "LYRM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00302998", "map_id": "WBGene00302998", "name": "LYRM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10630210", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10662828", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959486", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959490", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10662825", "map_id": "Q20696", "name": "SAMD8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00018735", "map_id": "WBGene00018735", "name": "SAMD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657539", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8849959", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_8849958", "map_id": "none", "name": "PI5P, PI3P, PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10657536", "map_id": "Q9U330", "name": "sac-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00012353", "map_id": "WBGene00012353", "name": "sac-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651392", "map_id": "none", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9757044", "map_id": "CHEBI:13193", "name": "hydrogen acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9757039", "map_id": "CHEBI:17499", "name": "hydrogen donor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10651389", "map_id": "Q18429", "name": "CHDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00007917", "map_id": "WBGene00007917", "name": "CHDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633516", "map_id": "none", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_870330", "map_id": "CHEBI:18297", "name": "I1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10657655", "map_id": "none", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851224", "map_id": "none", "name": "UDP,GDP,CDP,dTDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_8851227", "map_id": "none", "name": "UMP,GMP,CMP,dTMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_425969", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10657652", "map_id": "none", "name": "NTPDase4:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18411", "map_id": "Q18411", "name": "ntp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016380", "map_id": "WBGene00016380", "name": "ntp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599431", "map_id": "none", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31503", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615273", "map_id": "none", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601717", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601714", "map_id": "none", "name": "CTPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EC98", "map_id": "G5EC98", "name": "ctps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012316", "map_id": "WBGene00012316", "name": "ctps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599461", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599458", "map_id": "O18229", "name": "PGLS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013301", "map_id": "WBGene00013301", "name": "PGLS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633638", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633635", "map_id": "none", "name": "PPIP5K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91309", "map_id": "P91309", "name": "PPIP5K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018508", "map_id": "WBGene00018508", "name": "PPIP5K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598867", "map_id": "none", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10598864", "map_id": "O45228", "name": "prdh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00007197", "map_id": "WBGene00007197", "name": "prdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604743", "map_id": "none", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10633655", "map_id": "none", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599055", "map_id": "none", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30721", "map_id": "CHEBI:30817", "name": "UCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599052", "map_id": "Q20502", "name": "haly-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009813", "map_id": "WBGene00009813", "name": "haly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612334", "map_id": "none", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612323", "map_id": "none", "name": "eNOS:Caveolin-1:NOSTRIN:Dynamin-2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612332", "map_id": "none", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657382", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10598828", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10620205", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10635608", "map_id": "none", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046063", "map_id": "CHEBI:15530", "name": "LA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10611410", "map_id": "none", "name": "Creatine transport across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200381", "map_id": "CHEBI:16919", "name": "CRET", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29916", "map_id": "CHEBI:16919", "name": "CRET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611407", "map_id": "none", "name": "SLC6A8-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10632713", "map_id": "none", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1861779", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1606588", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10632710", "map_id": "none", "name": "ASAH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10632580", "map_id": "none", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605641", "map_id": "CHEBI:15681", "name": "GM3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10660506", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10660497", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A5HWB2", "map_id": "A5HWB2", "name": "ISCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012666", "map_id": "WBGene00012666", "name": "ISCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVZ9", "map_id": "Q9XVZ9", "name": "ISCA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013218", "map_id": "WBGene00013218", "name": "ISCA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660485", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XTU9", "map_id": "Q9XTU9", "name": "glrx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013029", "map_id": "WBGene00013029", "name": "glrx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660499", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660483", "map_id": "Q9XTU9", "name": "glrx-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10660504", "map_id": "Q21324", "name": "dnj-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00001033", "map_id": "WBGene00001033", "name": "dnj-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10650398", "map_id": "none", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650395", "map_id": "none", "name": "LHPP:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01926", "map_id": "O01926", "name": "LHPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007548", "map_id": "WBGene00007548", "name": "LHPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633649", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10656419", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10656416", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10657299", "map_id": "none", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10657295", "map_id": "none", "name": "DBI, (ACBD7)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q45EL0", "map_id": "Q45EL0", "name": "acbp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044603", "map_id": "WBGene00044603", "name": "acbp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09603", "map_id": "Q09603", "name": "ech-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001153", "map_id": "WBGene00001153", "name": "ech-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXJ2", "map_id": "Q9XXJ2", "name": "acbp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012457", "map_id": "WBGene00012457", "name": "acbp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8848288", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10657297", "map_id": "none", "name": "DBI,ACBD7:MCFA-CoA,LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10603989", "map_id": "none", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77337", "map_id": "CHEBI:15533", "name": "Octanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10602994", "map_id": "none", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390422", "map_id": "CHEBI:63818", "name": "HXDG3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602991", "map_id": "Q65ZI3", "name": "dhs-30", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00000993", "map_id": "WBGene00000993", "name": "dhs-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657658", "map_id": "none", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851233", "map_id": "none", "name": "UTP,GTP,CTP,dTTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10616356", "map_id": "none", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599690", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599687", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10650252", "map_id": "none", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787328", "map_id": "CHEBI:16132", "name": "dR5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10650249", "map_id": "Q19264", "name": "DERA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10646508", "map_id": "none", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662665", "map_id": "CHEBI:49108", "name": "Dopachrome", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10646505", "map_id": "none", "name": "DCT:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10598380", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598377", "map_id": "none", "name": "Homologues of PCK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44906", "map_id": "O44906", "name": "pck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021043", "map_id": "WBGene00021043", "name": "pck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYQ8", "map_id": "Q9TYQ8", "name": "pck-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019151", "map_id": "WBGene00019151", "name": "pck-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02286", "map_id": "O02286", "name": "pck-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665624", "map_id": "none", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665621", "map_id": "Q20538", "name": "SLCO2B1-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10632701", "map_id": "none", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1606573", "map_id": "CHEBI:18390", "name": "GalCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10632698", "map_id": "Q95QT2", "name": "GALC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00016207", "map_id": "WBGene00016207", "name": "GALC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649955", "map_id": "none", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35305", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649952", "map_id": "none", "name": "PYCRL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10662666", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649957", "map_id": "O45228", "name": "prdh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10648449", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10648446", "map_id": "none", "name": "ACOT2,9, THEM4,5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94245", "map_id": "Q94245", "name": "ACOT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019015", "map_id": "WBGene00019015", "name": "ACOT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632945", "map_id": "none", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10648429", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10648426", "map_id": "none", "name": "Cytosolic ACOTs, THEM4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34419", "map_id": "P34419", "name": "ACOT13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018370", "map_id": "WBGene00018370", "name": "ACOT13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10666184", "map_id": "none", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10613760", "map_id": "none", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352329", "map_id": "CHEBI:15768", "name": "DIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352036", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352331", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10657333", "map_id": "none", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657329", "map_id": "Q9XVJ0", "name": "acbp-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011731", "map_id": "WBGene00011731", "name": "acbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657331", "map_id": "none", "name": "ACBD6:LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ0", "map_id": "Q9XVJ0", "name": "acbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649964", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10649961", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O45228", "map_id": "O45228", "name": "prdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636076", "map_id": "none", "name": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142718", "map_id": "CHEBI:15628", "name": "15S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142707", "map_id": "CHEBI:15558", "name": "15S-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10636073", "map_id": "none", "name": "GPX1/2/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620511", "map_id": "none", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620503", "map_id": "Q93569", "name": "phospho-p-S,S132,T-CERT1-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620508", "map_id": "Q8WQ99", "name": "csnk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013709", "map_id": "WBGene00013709", "name": "csnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648998", "map_id": "none", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5693762", "map_id": "CHEBI:76931", "name": "NAAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5693772", "map_id": "CHEBI:16953", "name": "NAASP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648995", "map_id": "none", "name": "NAALADases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10664531", "map_id": "none", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10664528", "map_id": "none", "name": "FUT4,5,9(10,11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10602219", "map_id": "none", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10664696", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605649", "map_id": "CHEBI:140919", "name": "Type 1 DSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605651", "map_id": "CHEBI:140915", "name": "dsLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10655995", "map_id": "none", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_6808468", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_2453691", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10655992", "map_id": "none", "name": "Homologues of ALDH3B2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10649930", "map_id": "none", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693325", "map_id": "CHEBI:30913", "name": "PPCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6783877", "map_id": "CHEBI:58769", "name": "P6C", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10649927", "map_id": "Q18006", "name": "PIPOX", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10606628", "map_id": "none", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606626", "map_id": "none", "name": "ACC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633652", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10623695", "map_id": "none", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10623692", "map_id": "none", "name": "GLUT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NEI8", "map_id": "Q9NEI8", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21385", "map_id": "Q21385", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYQ1", "map_id": "Q9GYQ1", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21382", "map_id": "Q21382", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21381", "map_id": "Q21381", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRR9", "map_id": "Q5WRR9", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646096", "map_id": "none", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10636042", "map_id": "none", "name": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9731626", "map_id": "CHEBI:144842", "name": "N(6)-methyl-AMP(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10650368", "map_id": "none", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788802", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_6788801", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10650365", "map_id": "Q09629", "name": "AK4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10654704", "map_id": "none", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799493", "map_id": "CHEBI:58272", "name": "3PDGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10654701", "map_id": "Q09235", "name": "GLYCTK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015733", "map_id": "WBGene00015733", "name": "GLYCTK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604818", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10665619", "map_id": "none", "name": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10665616", "map_id": "O01735", "name": "FLVCR1-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10630839", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10648813", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648810", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10633718", "map_id": "none", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10651186", "map_id": "none", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6793610", "map_id": "CHEBI:26833", "name": "S", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10651176", "map_id": "Q20634", "name": "gcsh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6793613", "map_id": "CHEBI:17319", "name": "5dAde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_379705", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10651183", "map_id": "none", "name": "LIAS:2(4Fe-4S)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21452", "map_id": "Q21452", "name": "LIAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010809", "map_id": "WBGene00010809", "name": "LIAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633187", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10664715", "map_id": "none", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605685", "map_id": "CHEBI:140918", "name": "Type 2 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605661", "map_id": "CHEBI:140916", "name": "sLeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10664712", "map_id": "none", "name": "FUT3,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10603993", "map_id": "none", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10649064", "map_id": "none", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10649061", "map_id": "none", "name": "PXLP-K754-GLDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21962", "map_id": "Q21962", "name": "gldc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020022", "map_id": "WBGene00020022", "name": "gldc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599420", "map_id": "none", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_35139", "map_id": "CHEBI:17311", "name": "TMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113546", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599417", "map_id": "none", "name": "TMLHE:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21526", "map_id": "Q21526", "name": "gbh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001523", "map_id": "WBGene00001523", "name": "gbh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599822", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599819", "map_id": "Q18496", "name": "acs-19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007969", "map_id": "WBGene00007969", "name": "acs-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599453", "map_id": "none", "name": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599450", "map_id": "none", "name": "BBOX1:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19000", "map_id": "Q19000", "name": "gbh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001522", "map_id": "WBGene00001522", "name": "gbh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599771", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10617719", "map_id": "none", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389664", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193446", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389680", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617716", "map_id": "none", "name": "AGXT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10604547", "map_id": "none", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500077", "map_id": "none", "name": "(d)GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500071", "map_id": "none", "name": "(d)GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:57673", "map_id": "CHEBI:57673", "name": "CHEBI:57673", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632681", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429776", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1610735", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10632678", "map_id": "none", "name": "SMPD2,3:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45870", "map_id": "O45870", "name": "SMPD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012105", "map_id": "WBGene00012105", "name": "SMPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632559", "map_id": "none", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10632556", "map_id": "none", "name": "GBA:SAPC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "G5ECR8", "map_id": "G5ECR8", "name": "gba-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008706", "map_id": "WBGene00008706", "name": "gba-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606619", "map_id": "none", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10612354", "map_id": "none", "name": "NOSTRIN mediated translocation of eNOS from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane" }, { "id": "species_10612352", "map_id": "none", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10606598", "map_id": "none", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606592", "map_id": "none", "name": "AMPK heterotrimer (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606596", "map_id": "none", "name": "AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10599269", "map_id": "none", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10610962", "map_id": "none", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113782", "map_id": "CHEBI:58225", "name": "G6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10610959", "map_id": "C0RSI9", "name": "SLC37A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00302978", "map_id": "WBGene00302978", "name": "SLC37A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10634928", "map_id": "none", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023974", "map_id": "none", "name": "1/3-PP-IP5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:62922", "map_id": "CHEBI:62922", "name": "CHEBI:62922", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617792", "map_id": "none", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389819", "map_id": "CHEBI:16995", "name": "OX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10633285", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10633251", "map_id": "none", "name": "MTM1,MTMR2,MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599247", "map_id": "none", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599244", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10663251", "map_id": "none", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787326", "map_id": "CHEBI:11563", "name": "dR1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598857", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10598854", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10665960", "map_id": "none", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620182", "map_id": "Q18425", "name": "sphk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10665958", "map_id": "none", "name": "SPHK2:SPHK2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6625", "map_id": "LigandDisplayForward?ligandId=6625", "name": "LigandDisplayForward?ligandId=6625", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10641", "map_id": "LigandDisplayForward?ligandId=10641", "name": "LigandDisplayForward?ligandId=10641", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10219", "map_id": "LigandDisplayForward?ligandId=10219", "name": "LigandDisplayForward?ligandId=10219", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6624", "map_id": "LigandDisplayForward?ligandId=6624", "name": "LigandDisplayForward?ligandId=6624", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10633210", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10620172", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620169", "map_id": "none", "name": "LASS proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7Z139", "map_id": "Q7Z139", "name": "hyl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002044", "map_id": "WBGene00002044", "name": "hyl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED45", "map_id": "G5ED45", "name": "hyl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002043", "map_id": "WBGene00002043", "name": "hyl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWE9", "map_id": "Q9XWE9", "name": "lagr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006505", "map_id": "WBGene00006505", "name": "lagr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603843", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603840", "map_id": "none", "name": "AMPD tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604119", "map_id": "none", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500347", "map_id": "none", "name": "(d)CMP, TMP, (d)UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500346", "map_id": "none", "name": "(d)C, T, (d)U", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604116", "map_id": "none", "name": "NT5C3 holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09315", "map_id": "Q09315", "name": "NT5C3-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZJ9", "map_id": "Q95ZJ9", "name": "NT5C3-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658877", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604824", "map_id": "none", "name": "RNR (M1M2B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10613692", "map_id": "none", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10602198", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10664494", "map_id": "none", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605394", "map_id": "CHEBI:140910", "name": "LeB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10633555", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601623", "map_id": "none", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599804", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599801", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10603975", "map_id": "none", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10602168", "map_id": "none", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602165", "map_id": "H2KYI5", "name": "adah-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015551", "map_id": "WBGene00015551", "name": "adah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614865", "map_id": "none", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265281", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10633254", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10633615", "map_id": "none", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629756", "map_id": "CHEBI:4170", "name": "Glc6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10633612", "map_id": "none", "name": "ISYNA1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED01", "map_id": "G5ED01", "name": "inos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012148", "map_id": "WBGene00012148", "name": "inos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10651384", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10599091", "map_id": "P46562", "name": "alh-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10599083", "map_id": "none", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30176", "map_id": "CHEBI:16927", "name": "SACN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10599080", "map_id": "none", "name": "AASS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "U4PFH6", "map_id": "U4PFH6", "name": "aass-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019819", "map_id": "WBGene00019819", "name": "aass-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613678", "map_id": "none", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613675", "map_id": "none", "name": "TH:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90986", "map_id": "P90986", "name": "cat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000296", "map_id": "WBGene00000296", "name": "cat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10649079", "map_id": "none", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10649076", "map_id": "none", "name": "DLD dimer:2xFAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10656390", "map_id": "none", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10633085", "map_id": "Q9N589", "name": "mtm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10649087", "map_id": "none", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5694080", "map_id": "CHEBI:34560", "name": "BaP4,5O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5694091", "map_id": "CHEBI:81621", "name": "BaP4,5-DHD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10649084", "map_id": "Q23068", "name": "EPHX1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020909", "map_id": "WBGene00020909", "name": "EPHX1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617777", "map_id": "none", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10617774", "map_id": "none", "name": "DAO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10643266", "map_id": "none", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432031", "map_id": "CHEBI:17632", "name": "NO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611257", "map_id": "none", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10603987", "map_id": "none", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10604559", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10613762", "map_id": "none", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10643233", "map_id": "none", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1638840", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5339515", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10643230", "map_id": "none", "name": "Homologues of GLTPD1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A3P6NP42", "map_id": "A0A3P6NP42", "name": "tag-296", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018632", "map_id": "WBGene00018632", "name": "tag-296", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21333", "map_id": "Q21333", "name": "GLTPD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010666", "map_id": "WBGene00010666", "name": "GLTPD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657675", "map_id": "none", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8851462", "map_id": "none", "name": "CDP,GDP,IDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:58280", "map_id": "CHEBI:58280", "name": "CHEBI:58280", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8851461", "map_id": "none", "name": "CMP,GMP,IMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10657672", "map_id": "none", "name": "NTPDase6:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10665627", "map_id": "none", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10632920", "map_id": "none", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10632917", "map_id": "Q17540", "name": "ENPP7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10656848", "map_id": "none", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6813734", "map_id": "CHEBI:58444", "name": "GroPIns", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656845", "map_id": "Q9UAW8", "name": "GDE1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020446", "map_id": "WBGene00020446", "name": "GDE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660188", "map_id": "none", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8876775", "map_id": "CHEBI:18323", "name": "Anserine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660185", "map_id": "O62483", "name": "CARNMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013015", "map_id": "WBGene00013015", "name": "CARNMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599086", "map_id": "none", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10625272", "map_id": "none", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893598", "map_id": "CHEBI:30882", "name": "2OGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10648833", "map_id": "none", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692409", "map_id": "CHEBI:196991", "name": "4HPCP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692433", "map_id": "CHEBI:3410", "name": "CXPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648830", "map_id": "none", "name": "Homologues of ALDH3A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602145", "map_id": "none", "name": "APRT catalyzes the conversion of adenine to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602142", "map_id": "none", "name": "APRT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10615271", "map_id": "none", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615268", "map_id": "none", "name": "SLC25A12,13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q21153", "map_id": "Q21153", "name": "SLC25A12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019326", "map_id": "WBGene00019326", "name": "SLC25A12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636569", "map_id": "none", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10634926", "map_id": "none", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10613746", "map_id": "none", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10613743", "map_id": "Q23616", "name": "SLC5A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10601727", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_500742", "map_id": "CHEBI:246422", "name": "dUMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601724", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EET2", "map_id": "G5EET2", "name": "dut-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010609", "map_id": "WBGene00010609", "name": "dut-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10636096", "map_id": "none", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142716", "map_id": "CHEBI:34144", "name": "12R-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10650343", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10650340", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10632912", "map_id": "none", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10632909", "map_id": "Q9TZI1", "name": "cerk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020398", "map_id": "WBGene00020398", "name": "cerk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10630220", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10630218", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10632619", "map_id": "none", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10632616", "map_id": "none", "name": "GLA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10623707", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623704", "map_id": "none", "name": "CTPS2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10638225", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10638222", "map_id": "K8ES01", "name": "cox-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00012895", "map_id": "WBGene00012895", "name": "cox-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620552", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620549", "map_id": "none", "name": "Homologues of 2xPalmC-SGMS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U3D4", "map_id": "Q9U3D4", "name": "sms-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004892", "map_id": "WBGene00004892", "name": "sms-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20735", "map_id": "Q20735", "name": "sms-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004893", "map_id": "WBGene00004893", "name": "sms-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYV2", "map_id": "Q9TYV2", "name": "sms-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021075", "map_id": "WBGene00021075", "name": "sms-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965Q4", "map_id": "Q965Q4", "name": "sms-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599065", "map_id": "none", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599062", "map_id": "none", "name": "UROC1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NAE2", "map_id": "Q9NAE2", "name": "UROC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013103", "map_id": "WBGene00013103", "name": "UROC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613764", "map_id": "none", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10656409", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10614996", "map_id": "none", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10633833", "map_id": "none", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861782", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10633830", "map_id": "O01893", "name": "GBA2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00019965", "map_id": "WBGene00019965", "name": "GBA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603957", "map_id": "none", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10630813", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10656977", "map_id": "none", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6814253", "map_id": "CHEBI:58168", "name": "LysoPtdCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10656974", "map_id": "none", "name": "Homologues of PNPLA6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q21534", "map_id": "Q21534", "name": "PNPLA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022718", "map_id": "WBGene00022718", "name": "PNPLA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02331", "map_id": "Q02331", "name": "PNPLA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648910", "map_id": "none", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10648907", "map_id": "O61213", "name": "bli-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000253", "map_id": "WBGene00000253", "name": "bli-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598764", "map_id": "none", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598761", "map_id": "none", "name": "ASNS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16924", "map_id": "O16924", "name": "asns-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003816", "map_id": "WBGene00003816", "name": "asns-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10632599", "map_id": "none", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605677", "map_id": "CHEBI:61048", "name": "GM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10650163", "map_id": "none", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6785915", "map_id": "CHEBI:18390", "name": "GalCer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10650160", "map_id": "none", "name": "Homologues of UGT8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604827", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10643238", "map_id": "none", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643235", "map_id": "P34669", "name": "MAGT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10643204", "map_id": "none", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643195", "map_id": "G4S7C7", "name": "nipa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00021820", "map_id": "WBGene00021820", "name": "nipa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642609", "map_id": "none", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642605", "map_id": "Q95QM5", "name": "unc-115", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006839", "map_id": "WBGene00006839", "name": "unc-115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642600", "map_id": "none", "name": "ADD1:ADD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10642607", "map_id": "none", "name": "ADD1:ADD2:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95QM5", "map_id": "Q95QM5", "name": "unc-115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10642621", "map_id": "none", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642617", "map_id": "none", "name": "ADD1:ADD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10642619", "map_id": "none", "name": "ADD1:ADD3:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10643246", "map_id": "none", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5673778", "map_id": "CHEBI:16283", "name": "CySS-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_379444", "map_id": "CHEBI:16283", "name": "CySS-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10643243", "map_id": "Q09500", "name": "ctns-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00008052", "map_id": "WBGene00008052", "name": "ctns-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660687", "map_id": "none", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932838", "map_id": "none", "name": "L-Arg,L-His,L-Lys", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_8932842", "map_id": "none", "name": "L-Arg,L-His,L-Lys", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660684", "map_id": "Q95XZ6", "name": "laat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00021546", "map_id": "WBGene00021546", "name": "laat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643218", "map_id": "none", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10643215", "map_id": "P34669", "name": "TUSC3(1-348)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10606449", "map_id": "none", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606444", "map_id": "O18209", "name": "wee-1.3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006940", "map_id": "WBGene00006940", "name": "wee-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606447", "map_id": "O18209", "name": "phospho-wee-1.3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10617413", "map_id": "none", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10617410", "map_id": "none", "name": "Heme transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "G4SRS5", "map_id": "G4SRS5", "name": "abtm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022281", "map_id": "WBGene00022281", "name": "abtm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17895", "map_id": "O17895", "name": "haf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001813", "map_id": "WBGene00001813", "name": "haf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10647412", "map_id": "none", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617481", "map_id": "none", "name": "Homologues of CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10630680", "map_id": "none", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1454930", "map_id": "CHEBI:25696", "name": "organic anion", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1454919", "map_id": "CHEBI:25696", "name": "organic anion", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10630677", "map_id": "none", "name": "ABCCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658922", "map_id": "none", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658885", "map_id": "none", "name": "Ub-misfolded nascent CFTR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10630270", "map_id": "none", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1369066", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1369027", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10630267", "map_id": "none", "name": "MTABC3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "G5EFD4", "map_id": "G5EFD4", "name": "hmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001815", "map_id": "WBGene00001815", "name": "hmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658934", "map_id": "none", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658883", "map_id": "none", "name": "Homologues of misfolded CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10642580", "map_id": "none", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5223341", "map_id": "none", "name": "23mer peptide", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5223344", "map_id": "none", "name": "23mer peptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10642577", "map_id": "none", "name": "ABCB9 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10642630", "map_id": "none", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10642626", "map_id": "Q19554", "name": "abcf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006512", "map_id": "WBGene00006512", "name": "abcf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10642628", "map_id": "none", "name": "ABCF1:EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19554", "map_id": "Q19554", "name": "abcf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617438", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617435", "map_id": "none", "name": "ABCD1-3 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10617484", "map_id": "none", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10658920", "map_id": "none", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10658909", "map_id": "none", "name": "ERAD complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A3QMC6", "map_id": "A3QMC6", "name": "erl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016592", "map_id": "WBGene00016592", "name": "erl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09463", "map_id": "Q09463", "name": "rnf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004381", "map_id": "WBGene00004381", "name": "rnf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658915", "map_id": "none", "name": "misfolded CFTR:ERAD complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617469", "map_id": "none", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10617467", "map_id": "none", "name": "PEX19:ABCD1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10658918", "map_id": "none", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10658911", "map_id": "none", "name": "Ub-misfolded nascent CFTR:ERAD complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10658913", "map_id": "none", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10647530", "map_id": "none", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5682283", "map_id": "CHEBI:18059", "name": "lipids", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5229279", "map_id": "CHEBI:18059", "name": "lipids", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10647527", "map_id": "none", "name": "Homologues of ABCA12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615447", "map_id": "none", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615444", "map_id": "G5EF96", "name": "unc-40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615442", "map_id": "G5EF96", "name": "unc-40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625999", "map_id": "none", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_167012", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10625996", "map_id": "none", "name": "ATP2C1/2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5EDU1", "map_id": "G5EDU1", "name": "pmr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004063", "map_id": "WBGene00004063", "name": "pmr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638045", "map_id": "none", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_2889081", "map_id": "none", "name": "Na+/Li+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_425815", "map_id": "CHEBI:49713", "name": "Li+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2889062", "map_id": "none", "name": "Na+/Li+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10638042", "map_id": "Q20273", "name": "slc-9b.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00009617", "map_id": "WBGene00009617", "name": "slc-9b.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619535", "map_id": "none", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_425978", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_425971", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_10619530", "map_id": "G5ED88", "name": "nhx-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00003733", "map_id": "WBGene00003733", "name": "nhx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622391", "map_id": "none", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609816", "map_id": "none", "name": "GLUT2 / SLC2A2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637543", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637540", "map_id": "H2L2L3", "name": "anoh-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10626047", "map_id": "none", "name": "ATP12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626044", "map_id": "none", "name": "ATP12A:ATP4B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16436", "map_id": "O16436", "name": "catp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015338", "map_id": "WBGene00015338", "name": "catp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFV6", "map_id": "G5EFV6", "name": "catp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007248", "map_id": "WBGene00007248", "name": "catp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBE7", "map_id": "G5EBE7", "name": "catp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013672", "map_id": "WBGene00013672", "name": "catp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90735", "map_id": "P90735", "name": "eat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001137", "map_id": "WBGene00001137", "name": "eat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16331", "map_id": "O16331", "name": "catp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015660", "map_id": "WBGene00015660", "name": "catp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10656840", "map_id": "none", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10656837", "map_id": "none", "name": "Homologues of NCEH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7JMM5", "map_id": "Q7JMM5", "name": "NCEH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19839", "map_id": "Q19839", "name": "trcs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009186", "map_id": "WBGene00009186", "name": "trcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWL5", "map_id": "Q9XWL5", "name": "nceh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012810", "map_id": "WBGene00012810", "name": "nceh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94187", "map_id": "Q94187", "name": "NCEH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10638040", "map_id": "none", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10638037", "map_id": "none", "name": "Homologues of SLC9B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XU88", "map_id": "Q9XU88", "name": "slc-9b.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010214", "map_id": "WBGene00010214", "name": "slc-9b.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20273", "map_id": "Q20273", "name": "slc-9b.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFS0", "map_id": "G5EFS0", "name": "SLC9B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009618", "map_id": "WBGene00009618", "name": "SLC9B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620374", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620371", "map_id": "none", "name": "GLUT7/11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10629117", "map_id": "none", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10615975", "map_id": "none", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375409", "map_id": "none", "name": "Gly, L-Pro", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375414", "map_id": "none", "name": "Gly, L-Pro", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10615972", "map_id": "O45936", "name": "slc-36.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10637530", "map_id": "none", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637478", "map_id": "none", "name": "Ub-SCNN channels", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_947590", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10637516", "map_id": "none", "name": "RAF1:SGK:TSC22D3:WPP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYK3", "map_id": "H2KYK3", "name": "TSC22D3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016269", "map_id": "WBGene00016269", "name": "TSC22D3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U290", "map_id": "Q9U290", "name": "TSC22D3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637522", "map_id": "X5M5N0", "name": "wnk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006941", "map_id": "WBGene00006941", "name": "wnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626107", "map_id": "none", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_10626104", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91203", "map_id": "P91203", "name": "tat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017174", "map_id": "WBGene00017174", "name": "tat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18182", "map_id": "O18182", "name": "tat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012360", "map_id": "WBGene00012360", "name": "tat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JPE3", "map_id": "Q7JPE3", "name": "tat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020784", "map_id": "WBGene00020784", "name": "tat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBH1", "map_id": "G5EBH1", "name": "tat-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009498", "map_id": "WBGene00009498", "name": "tat-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615157", "map_id": "none", "name": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352355", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_351990", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352359", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10615150", "map_id": "Q22682", "name": "glt-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10637617", "map_id": "none", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2730999", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10637614", "map_id": "none", "name": "CLCN7:OSTM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "G5EC75", "map_id": "G5EC75", "name": "clh-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000533", "map_id": "WBGene00000533", "name": "clh-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09322", "map_id": "Q09322", "name": "cup-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009627", "map_id": "WBGene00009627", "name": "cup-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659515", "map_id": "none", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10625831", "map_id": "none", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "reaction_10642981", "map_id": "none", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5252122", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5252016", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10642978", "map_id": "none", "name": "ATP13A4, 5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N323", "map_id": "Q9N323", "name": "catp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022010", "map_id": "WBGene00022010", "name": "catp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27533", "map_id": "Q27533", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012341", "map_id": "WBGene00012341", "name": "ATP13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21286", "map_id": "Q21286", "name": "catp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019493", "map_id": "WBGene00019493", "name": "catp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10643209", "map_id": "none", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622382", "map_id": "none", "name": "GLUT1 / SLC2A1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10643207", "map_id": "Q11184", "name": "let-756", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10662986", "map_id": "none", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662983", "map_id": "none", "name": "GLUT3 / SLC2A3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619506", "map_id": "none", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619503", "map_id": "none", "name": "SLC24A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EC02", "map_id": "G5EC02", "name": "ncx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003570", "map_id": "WBGene00003570", "name": "ncx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90858", "map_id": "P90858", "name": "ncx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003569", "map_id": "WBGene00003569", "name": "ncx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663007", "map_id": "none", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10663004", "map_id": "none", "name": "GLUT4 / SLC2A4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620458", "map_id": "none", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10616007", "map_id": "none", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375400", "map_id": "none", "name": "ligands of SLC36A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375411", "map_id": "none", "name": "ligands of SLC36A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10616004", "map_id": "none", "name": "Homologues of SLC36A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620122", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10620119", "map_id": "none", "name": "SLC17A6,7,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "true" }, { "id": "reaction_10620250", "map_id": "none", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428592", "map_id": "none", "name": "Inhibitory amino acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428632", "map_id": "none", "name": "Inhibitory amino acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "true" }, { "id": "species_10620247", "map_id": "P34579", "name": "unc-47", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "reaction_10637656", "map_id": "none", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637653", "map_id": "none", "name": "CLCN1/2/KA/KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2L0J1", "map_id": "H2L0J1", "name": "clh-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000531", "map_id": "WBGene00000531", "name": "clh-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22833", "map_id": "Q22833", "name": "clh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000528", "map_id": "WBGene00000528", "name": "clh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG93", "map_id": "G5EG93", "name": "clh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000529", "map_id": "WBGene00000529", "name": "clh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BMK9", "map_id": "Q9BMK9", "name": "clh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000530", "map_id": "WBGene00000530", "name": "clh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639280", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639277", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDR9", "map_id": "G5EDR9", "name": "ocr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003838", "map_id": "WBGene00003838", "name": "ocr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22374", "map_id": "Q22374", "name": "ocr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003840", "map_id": "WBGene00003840", "name": "ocr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T666", "map_id": "Q8T666", "name": "cup-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61220", "map_id": "O61220", "name": "ocr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003839", "map_id": "WBGene00003839", "name": "ocr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20766", "map_id": "Q20766", "name": "gtl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001796", "map_id": "WBGene00001796", "name": "gtl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34641", "map_id": "P34641", "name": "ced-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000425", "map_id": "WBGene00000425", "name": "ced-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23141", "map_id": "Q23141", "name": "trpl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020972", "map_id": "WBGene00020972", "name": "trpl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3Y9", "map_id": "Q9N3Y9", "name": "ocr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003841", "map_id": "WBGene00003841", "name": "ocr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECM4", "map_id": "G5ECM4", "name": "gtl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001795", "map_id": "WBGene00001795", "name": "gtl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93971", "map_id": "Q93971", "name": "gon-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001651", "map_id": "WBGene00001651", "name": "gon-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19377", "map_id": "Q19377", "name": "TRPM7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008731", "map_id": "WBGene00008731", "name": "TRPM7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620097", "map_id": "none", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428037", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:90799", "map_id": "CHEBI:90799", "name": "CHEBI:90799", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47923", "map_id": "CHEBI:47923", "name": "CHEBI:47923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428026", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620094", "map_id": "Q17758", "name": "pept-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003876", "map_id": "WBGene00003876", "name": "pept-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10663009", "map_id": "none", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10637671", "map_id": "none", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637668", "map_id": "Q20332", "name": "ttyh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00009632", "map_id": "WBGene00009632", "name": "ttyh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648663", "map_id": "none", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_389545", "map_id": "CHEBI:151", "name": "ISCIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648656", "map_id": "none", "name": "ACO1:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23500", "map_id": "Q23500", "name": "aco-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000040", "map_id": "WBGene00000040", "name": "aco-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665480", "map_id": "none", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10665478", "map_id": "none", "name": "ASIC trimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFH3", "map_id": "G5EFH3", "name": "del-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010334", "map_id": "WBGene00010334", "name": "del-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91103", "map_id": "P91103", "name": "delm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016063", "map_id": "WBGene00016063", "name": "delm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10025", "map_id": "Q10025", "name": "del-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020897", "map_id": "WBGene00020897", "name": "del-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G3MU02", "map_id": "G3MU02", "name": "acd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007775", "map_id": "WBGene00007775", "name": "acd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01664", "map_id": "O01664", "name": "acd-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020903", "map_id": "WBGene00020903", "name": "acd-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22970", "map_id": "Q22970", "name": "acd-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017879", "map_id": "WBGene00017879", "name": "acd-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91102", "map_id": "P91102", "name": "acd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016064", "map_id": "WBGene00016064", "name": "acd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18077", "map_id": "Q18077", "name": "del-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015957", "map_id": "WBGene00015957", "name": "del-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45402", "map_id": "O45402", "name": "delm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009073", "map_id": "WBGene00009073", "name": "delm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MPW0", "map_id": "Q8MPW0", "name": "del-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011891", "map_id": "WBGene00011891", "name": "del-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGI5", "map_id": "G5EGI5", "name": "flr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001465", "map_id": "WBGene00001465", "name": "flr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91100", "map_id": "P91100", "name": "acd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016066", "map_id": "WBGene00016066", "name": "acd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637417", "map_id": "none", "name": "ASIC trimers:H+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658135", "map_id": "none", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658125", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658133", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10619627", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619624", "map_id": "none", "name": "SLC9A1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637666", "map_id": "none", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637661", "map_id": "Q20332", "name": "ttyh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10637927", "map_id": "none", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637915", "map_id": "none", "name": "BESTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19978", "map_id": "Q19978", "name": "best-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009340", "map_id": "WBGene00009340", "name": "best-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18303", "map_id": "Q18303", "name": "best-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007808", "map_id": "WBGene00007808", "name": "best-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16779", "map_id": "O16779", "name": "best-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00206487", "map_id": "WBGene00206487", "name": "best-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17205", "map_id": "O17205", "name": "best-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015288", "map_id": "WBGene00015288", "name": "best-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"map_id": "WBGene00007204", "name": "best-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YXH3", "map_id": "Q7YXH3", "name": "best-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020046", "map_id": "WBGene00020046", "name": "best-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "J7RNL4", "map_id": "J7RNL4", "name": "BEST4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00220250", "map_id": "WBGene00220250", "name": "BEST4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22566", "map_id": "Q22566", "name": "best-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020559", "map_id": "WBGene00020559", "name": "best-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17851", "map_id": "Q17851", "name": "best-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015628", "map_id": "WBGene00015628", "name": "best-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21973", "map_id": "Q21973", "name": "best-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011258", "map_id": "WBGene00011258", "name": "best-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45435", "map_id": "O45435", "name": "best-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009323", "map_id": "WBGene00009323", "name": "best-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23369", "map_id": "Q23369", "name": "best-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013921", "map_id": "WBGene00013921", "name": "best-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45363", "map_id": "O45363", "name": "best-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008821", "map_id": "WBGene00008821", "name": "best-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYR2", "map_id": "A5JYR2", "name": "best-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014989", "map_id": "WBGene00014989", "name": "best-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18303", "map_id": "O18303", "name": "best-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014102", "map_id": "WBGene00014102", "name": "best-25", "type": 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"protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013520", "map_id": "WBGene00013520", "name": "best-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17671", "map_id": "O17671", "name": "best-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008186", "map_id": "WBGene00008186", "name": "best-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17528", "map_id": "Q17528", "name": "best-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007203", "map_id": "WBGene00007203", "name": "best-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17206", "map_id": "O17206", "name": "best-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015286", "map_id": "WBGene00015286", "name": "best-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34672", "map_id": "P34672", "name": "best-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022797", "map_id": "WBGene00022797", "name": "best-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94175", "map_id": "Q94175", "name": "best-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016613", "map_id": "WBGene00016613", "name": "best-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62095", "map_id": "O62095", "name": "best-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007988", "map_id": "WBGene00007988", "name": "best-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658393", "map_id": "none", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658389", "map_id": "none", "name": "STOML3, (STOM)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7YZV6", "map_id": "Q7YZV6", "name": "sto-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006067", "map_id": "WBGene00006067", "name": "sto-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20657", "map_id": "Q20657", "name": "sto-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006065", "map_id": "WBGene00006065", "name": "sto-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658391", "map_id": "none", "name": "ASIC trimers:H+:STOML3,(STOM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607855", "map_id": "none", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10607851", "map_id": "Q7JP80", "name": "LDLR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10607853", "map_id": "Q7JP80", "name": "LDLR", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10637985", "map_id": "none", "name": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2855229", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_261378", "compartment_display": "sarcoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10637970", "map_id": "none", "name": "RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261659", "compartment_display": "sarcoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20203", "map_id": "Q20203", "name": "csq-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000822", "map_id": "WBGene00000822", "name": "csq-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8WHT8", "map_id": "A8WHT8", "name": "ASPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010703", "map_id": "WBGene00010703", "name": "ASPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C3E8", "map_id": "A0A2C9C3E8", "name": "unc-68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006801", "map_id": "WBGene00006801", "name": "unc-68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637983", "map_id": "none", "name": "Homologues of CLIC2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45405", "map_id": "O45405", "name": "exl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001371", "map_id": "WBGene00001371", "name": "exl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQA4", "map_id": "Q8WQA4", "name": "exc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001365", "map_id": "WBGene00001365", "name": "exc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619715", "map_id": "none", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619712", "map_id": "none", "name": "SLC12A4,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09573", "map_id": "Q09573", "name": "kcc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019289", "map_id": "WBGene00019289", "name": "kcc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "S6FWN4", "map_id": "S6FWN4", "name": "kcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006504", "map_id": "WBGene00006504", "name": "kcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZC3", "map_id": "H2KZC3", "name": "kcc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019205", "map_id": "WBGene00019205", "name": "kcc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660137", "map_id": "none", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10660133", "map_id": "none", "name": "NPC1:CHOL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10660131", "map_id": "P34389", "name": "ncr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10637444", "map_id": "none", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10637442", "map_id": "none", "name": "Homologues of ASIC4", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_2672383", "map_id": "CHEBI:35475", "name": "NSAID", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10660129", "map_id": "none", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10660125", "map_id": "O17271", "name": "heh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10660127", "map_id": "none", "name": "NPC2:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10620016", "map_id": "none", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620013", "map_id": "Q23530", "name": "SLC34A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10662860", "map_id": "none", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959777", "map_id": "none", "name": "SLC25A29 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28229", "map_id": "CHEBI:28229", "name": "CHEBI:28229", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27747", "map_id": "CHEBI:27747", "name": "CHEBI:27747", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8959775", "map_id": "none", "name": "SLC25A29 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10662857", "map_id": "Q8I4M0", "name": "slc-25a29", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008320", "map_id": "WBGene00008320", "name": "slc-25a29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620008", "map_id": "none", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620005", "map_id": "none", "name": "Type III Na+/Pi cotransporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17404", "map_id": "O17404", "name": "pitr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017312", "map_id": "WBGene00017312", "name": "pitr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45220", "map_id": "O45220", "name": "pitr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007141", "map_id": "WBGene00007141", "name": "pitr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17454", "map_id": "Q17454", "name": "pitr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015054", "map_id": "WBGene00015054", "name": "pitr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91840", "map_id": "P91840", "name": "pitr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012285", "map_id": "WBGene00012285", "name": "pitr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17455", "map_id": "Q17455", "name": "pitr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015055", "map_id": "WBGene00015055", "name": "pitr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18697", "map_id": "Q18697", "name": "pitr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016739", "map_id": "WBGene00016739", "name": "pitr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660180", "map_id": "none", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8876704", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10660175", "map_id": "Q17498", "name": "mboa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007174", "map_id": "WBGene00007174", "name": "mboa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625823", "map_id": "none", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_917828", "map_id": "CHEBI:10545", "name": "e-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10625820", "map_id": "none", "name": "CYBRD1:Heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34465", "map_id": "P34465", "name": "CYBRD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018210", "map_id": "WBGene00018210", "name": "CYBRD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16271", "map_id": "O16271", "name": "CYBRD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16272", "map_id": "O16272", "name": "CYBRD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615166", "map_id": "none", "name": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_212615", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10615161", "map_id": "Q22682", "name": "glt-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10626007", "map_id": "none", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10626004", "map_id": "G5EE14", "name": "cua-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00000834", "map_id": "WBGene00000834", "name": "cua-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648767", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648660", "map_id": "Q23500", "name": "aco-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648758", "map_id": "Q23500", "name": "aco-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648764", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10648852", "map_id": "none", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692450", "map_id": "CHEBI:36916", "name": "cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692484", "map_id": "CHEBI:36916", "name": "cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10648849", "map_id": "none", "name": "Homologues of ATP13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10620426", "map_id": "none", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429078", "map_id": "none", "name": "Fru,Glc,urate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429148", "map_id": "none", "name": "Fru,Glc,urate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620423", "map_id": "none", "name": "Homologues of SLC2A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10666181", "map_id": "none", "name": "ATP4A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10666178", "map_id": "none", "name": "ATP4A:ATP4B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10631304", "map_id": "none", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691103", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621144", "map_id": "none", "name": "Ferritin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619675", "map_id": "none", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619672", "map_id": "none", "name": "Homologues of SLC12A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H8ESD5", "map_id": "H8ESD5", "name": "nkcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012543", "map_id": "WBGene00012543", "name": "nkcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34261", "map_id": "P34261", "name": "SLC12A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015131", "map_id": "WBGene00015131", "name": "SLC12A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665971", "map_id": "none", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639225", "map_id": "none", "name": "Homologues of TRPV1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625842", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "reaction_10619528", "map_id": "none", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_425999", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_425977", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_10619525", "map_id": "G5ED88", "name": "nhx-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10619514", "map_id": "none", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425810", "map_id": "CHEBI:49713", "name": "Li+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619511", "map_id": "P34322", "name": "ncx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10662981", "map_id": "none", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10662978", "map_id": "none", "name": "GLUT14 / SLC2A14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619639", "map_id": "none", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_425958", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10619636", "map_id": "none", "name": "SLC9A7/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5ED88", "map_id": "G5ED88", "name": "nhx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBN7", "map_id": "G5EBN7", "name": "nhx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003735", "map_id": "WBGene00003735", "name": "nhx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619666", "map_id": "none", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619663", "map_id": "none", "name": "SLC12A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637918", "map_id": "none", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10650003", "map_id": "none", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10649973", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10650001", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane", "complex": "true" }, { "id": "reaction_10650005", "map_id": "none", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10649999", "map_id": "none", "name": "Clathrin:AP2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10620099", "map_id": "none", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428027", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_427997", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10630870", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10622388", "map_id": "none", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622384", "map_id": "none", "name": "GLUT1:ATP tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10660135", "map_id": "none", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10648755", "map_id": "none", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5691135", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10648752", "map_id": "none", "name": "FTMT 24mer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10620088", "map_id": "none", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10620064", "map_id": "G5EEK8", "name": "sca-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10620086", "map_id": "none", "name": "CAMK2 heteromer:CALM:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620519", "map_id": "none", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10648841", "map_id": "none", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1981162", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10648838", "map_id": "P90747", "name": "catp-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007514", "map_id": "WBGene00007514", "name": "catp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658121", "map_id": "none", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10658118", "map_id": "Q18934", "name": "slc-25a26", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008364", "map_id": "WBGene00008364", "name": "slc-25a26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660027", "map_id": "none", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660024", "map_id": "none", "name": "SLC25A18,A22", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q20847", "map_id": "Q20847", "name": "slc-25a18.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018901", "map_id": "WBGene00018901", "name": "slc-25a18.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93540", "map_id": "Q93540", "name": "slc-25a18.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008979", "map_id": "WBGene00008979", "name": "slc-25a18.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648776", "map_id": "none", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613629", "map_id": "Q17389", "name": "cul-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10648774", "map_id": "none", "name": "CANDI:CUL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622386", "map_id": "none", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10637553", "map_id": "none", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2731008", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10637548", "map_id": "G5EGT4", "name": "clh-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00000532", "map_id": "WBGene00000532", "name": "clh-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10648658", "map_id": "none", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10648654", "map_id": "Q23500", "name": "aco-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690881", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607567", "map_id": "none", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607560", "map_id": "none", "name": "CCNB:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607562", "map_id": "none", "name": "CCNB:p-T14-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607564", "map_id": "O18209", "name": "wee-1.3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607608", "map_id": "none", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607606", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607600", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638343", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10638290", "map_id": "none", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10638283", "map_id": "none", "name": "p-S252-BORA:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2FLK2", "map_id": "H2FLK2", "name": "spat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010198", "map_id": "WBGene00010198", "name": "spat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10638287", "map_id": "H2FLK2", "name": "phospho-spat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607552", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607520", "map_id": "none", "name": "cytoplasmic Cyclin B1:Cdc2 complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607550", "map_id": "none", "name": "nuclear Cyclin B1:Cdc2 complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10638363", "map_id": "none", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10638345", "map_id": "Q9N2L7", "name": "plk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10638360", "map_id": "none", "name": "Phosphorylated Myosin Phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607604", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607602", "map_id": "none", "name": "CCNA:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10607584", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10607532", "map_id": "none", "name": "CCNB1:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10607573", "map_id": "none", "name": "CCNB1:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10658258", "map_id": "none", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10658250", "map_id": "none", "name": "MeL-PP2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10658255", "map_id": "P46554", "name": "lcmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007137", "map_id": "WBGene00007137", "name": "lcmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658266", "map_id": "none", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8857797", "map_id": "CHEBI:17790", "name": "methanol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10658263", "map_id": "Q9BIB3", "name": "PPME1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007188", "map_id": "WBGene00007188", "name": "PPME1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607569", "map_id": "none", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607558", "map_id": "P34556", "name": "cdk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607556", "map_id": "none", "name": "CCNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657946", "map_id": "none", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657941", "map_id": "none", "name": "SCF-FBXL7:PolyUb-AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01427", "map_id": "O01427", "name": "air-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000099", "map_id": "WBGene00000099", "name": "air-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDL3", "map_id": "G5EDL3", "name": "air-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000098", "map_id": "WBGene00000098", "name": "air-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657884", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607598", "map_id": "none", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607596", "map_id": "none", "name": "CCNA:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607580", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607536", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10607496", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10657944", "map_id": "none", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657898", "map_id": "none", "name": "SCF-FBXL7:AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10640968", "map_id": "none", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10640966", "map_id": "H2FLK2", "name": "spat-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10638281", "map_id": "H2FLK2", "name": "phospho-spat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607619", "map_id": "none", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10607518", "map_id": "none", "name": "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607548", "map_id": "none", "name": "p-4S-CCNB1:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10657900", "map_id": "none", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10657896", "map_id": "none", "name": "Homologues of AURKA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607617", "map_id": "none", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607610", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607614", "map_id": "none", "name": "CRS kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10658008", "map_id": "none", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10658004", "map_id": "none", "name": "GGA1,2,3:RAB5:GTP:RABGEF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "A0A486WY48", "map_id": "A0A486WY48", "name": "rabx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012644", "map_id": "WBGene00012644", "name": "rabx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10657982", "map_id": "Q9U2D8", "name": "tbc-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00012894", "map_id": "WBGene00012894", "name": "tbc-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658006", "map_id": "none", "name": "TBC1D3:GGA:RAB5:GTP:RABGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q9U2D8", "map_id": "Q9U2D8", "name": "tbc-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658113", "map_id": "none", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10658104", "map_id": "none", "name": "Homologues of ULK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "true" }, { "id": "species_10658109", "map_id": "Q21928", "name": "tbc-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "WBGene00044061", "map_id": "WBGene00044061", "name": "tbc-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658098", "map_id": "O01803", "name": "rab-11.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "false" }, { "id": "species_10658111", "map_id": "none", "name": "TBC1D14:RAB11:ULK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q21928", "map_id": "Q21928", "name": "tbc-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658051", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10658012", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10658049", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10658022", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10658014", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10658020", "map_id": "Q23419", "name": "tbc-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022880", "map_id": "WBGene00022880", "name": "tbc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658045", "map_id": "none", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10658041", "map_id": "H2KZZ6", "name": "tbc-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018075", "map_id": "WBGene00018075", "name": "tbc-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10658043", "map_id": "none", "name": "RABGAP1:RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "H2KZZ6", "map_id": "H2KZZ6", "name": "tbc-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10657976", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10657953", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10657955", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10657974", "map_id": "none", "name": "RAB35 specific TBC RabGAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20436", "map_id": "Q20436", "name": "tbc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009726", "map_id": "WBGene00009726", "name": "tbc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ54", "map_id": "H2KZ54", "name": "tbc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016292", "map_id": "WBGene00016292", "name": "tbc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10658036", "map_id": "none", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10658025", "map_id": "O44873", "name": "tbc-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_19363", "compartment_display": "microvillus", "complex": "false" }, { "id": "species_10658034", "map_id": "none", "name": "TBC1D10A:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "reaction_10646156", "map_id": "none", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646152", "map_id": "none", "name": "PCNA:RPA:RFC:TLS-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604720", "map_id": "none", "name": "POLD,POLE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646154", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10620944", "map_id": "none", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619299", "map_id": "P39055", "name": "dyn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620938", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8WQB3", "map_id": "Q8WQB3", "name": "apg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000158", "map_id": "WBGene00000158", "name": "apg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01755", "map_id": "O01755", "name": "apm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000150", "map_id": "WBGene00000150", "name": "apm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22616", "map_id": "Q22616", "name": "blos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011872", "map_id": "WBGene00011872", "name": "blos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16369", "map_id": "O16369", "name": "aps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000159", "map_id": "WBGene00000159", "name": "aps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34387", "map_id": "P34387", "name": "crn-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007056", "map_id": "WBGene00007056", "name": "crn-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608669", "map_id": "B1V8A0", "name": "unc-57", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619297", "map_id": "none", "name": "Clathrin Triskelion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620942", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10614982", "map_id": "none", "name": "Arf1-GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10646797", "map_id": "none", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10646793", "map_id": "Q8WQB3", "name": "apg-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10625671", "map_id": "Q9U2F6", "name": "vps-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608649", "map_id": "Q17796", "name": "hgrs-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646795", "map_id": "none", "name": "AP1G2:HGS:CHMP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10643083", "map_id": "none", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10643079", "map_id": "none", "name": "CLAT:AP1:CLVS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10643081", "map_id": "none", "name": "CLAT:AP1:CLVS:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10621011", "map_id": "none", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621008", "map_id": "none", "name": "Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10612275", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612269", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10612271", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10612273", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615087", "map_id": "none", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615078", "map_id": "H2L099", "name": "gck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001526", "map_id": "WBGene00001526", "name": "gck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615082", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615080", "map_id": "H2L099", "name": "gck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615084", "map_id": "none", "name": "Caspase-3, Caspase-7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBM1", "map_id": "G5EBM1", "name": "csp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000819", "map_id": "WBGene00000819", "name": "csp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZP5", "map_id": "Q9TZP5", "name": "csp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000820", "map_id": "WBGene00000820", "name": "csp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615118", "map_id": "none", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608315", "map_id": "O17838", "name": "clsp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009127", "map_id": "WBGene00009127", "name": "clsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615095", "map_id": "O17838", "name": "clsp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10615093", "map_id": "O17838", "name": "clsp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10615115", "map_id": "none", "name": "active caspase-7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611885", "map_id": "none", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611879", "map_id": "P91156", "name": "acin-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016601", "map_id": "WBGene00016601", "name": "acin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611883", "map_id": "P91156", "name": "acin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611881", "map_id": "P91156", "name": "acin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611934", "map_id": "none", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611928", "map_id": "O44501", "name": "fnta-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611932", "map_id": "O44501", "name": "fnta-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611930", "map_id": "O44501", "name": "fnta-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612313", "map_id": "none", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612307", "map_id": "none", "name": "beta-catenin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612311", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612309", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612283", "map_id": "none", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612277", "map_id": "Q21227", "name": "apr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612279", "map_id": "Q21227", "name": "apr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612281", "map_id": "Q21227", "name": "apr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10614649", "map_id": "none", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614622", "map_id": "Q21443", "name": "lmn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10614624", "map_id": "Q21443", "name": "lmn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10614626", "map_id": "Q21443", "name": "lmn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10614646", "map_id": "none", "name": "active caspase-6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10664192", "map_id": "none", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10664190", "map_id": "none", "name": "active caspase-6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611908", "map_id": "none", "name": "Caspase-mediated cleavage of FADK 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611903", "map_id": "Q95YD4", "name": "kin-32", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611905", "map_id": "Q95YD4", "name": "kin-32", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605385", "map_id": "none", "name": "Caspase-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611852", "map_id": "none", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611848", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611850", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10664170", "map_id": "none", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10611844", "map_id": "none", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611839", "map_id": "Q9U308", "name": "jac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10611841", "map_id": "Q9U308", "name": "jac-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615122", "map_id": "none", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10615120", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10614975", "map_id": "none", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614969", "map_id": "H2L099", "name": "gck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614973", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614971", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611896", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611890", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10611894", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611892", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10611917", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611913", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10611915", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615065", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615061", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615063", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615059", "map_id": "none", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615053", "map_id": "Q9N554", "name": "ell-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615057", "map_id": "Q9N554", "name": "ell-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615055", "map_id": "Q9N554", "name": "ell-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10615091", "map_id": "none", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615089", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615049", "map_id": "Q8I103", "name": "zoo-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10614657", "map_id": "none", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10614651", "map_id": "Q21443", "name": "lmn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10614653", "map_id": "Q21443", "name": "lmn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10614655", "map_id": "Q21443", "name": "lmn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10615131", "map_id": "none", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615127", "map_id": "Q8WQC9", "name": "drp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615129", "map_id": "Q8WQC9", "name": "drp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10615072", "map_id": "G5EBI0", "name": "4D656", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021883", "map_id": "WBGene00021883", "name": "4D656", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10614404", "map_id": "none", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604948", "map_id": "P34722", "name": "tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614400", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10614402", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10615051", "map_id": "none", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615047", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10609819", "map_id": "none", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189246", "map_id": "none", "name": "Fru, Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_188995", "map_id": "CHEBI:17118", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_189219", "map_id": "none", "name": "Fru, Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10609777", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10609774", "map_id": "none", "name": "Homologues of SLC2A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604700", "map_id": "none", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604690", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFY1", "map_id": "G5EFY1", "name": "polh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018721", "map_id": "WBGene00018721", "name": "polh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604697", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604684", "map_id": "none", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604676", "map_id": "G5EFY1", "name": "polh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604680", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604682", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604693", "map_id": "none", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10646366", "map_id": "none", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646350", "map_id": "none", "name": "USP1:WDR48", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646361", "map_id": "P34547", "name": "usp-46", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10646363", "map_id": "P34547", "name": "usp-46", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10646348", "map_id": "Q20059", "name": "wdr-48", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10646089", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646066", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646085", "map_id": "none", "name": "RBX1:CUL4:DDB1:DTL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646087", "map_id": "none", "name": "RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646359", "map_id": "none", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646091", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646352", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646338", "map_id": "none", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646329", "map_id": "none", "name": "NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22557", "map_id": "Q22557", "name": "dvc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011834", "map_id": "WBGene00011834", "name": "dvc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QZ9", "map_id": "Q95QZ9", "name": "npl-4.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019121", "map_id": "WBGene00019121", "name": "npl-4.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19584", "map_id": "Q19584", "name": "ufd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006733", "map_id": "WBGene00006733", "name": "ufd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10646335", "map_id": "none", "name": "NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646331", "map_id": "none", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646327", "map_id": "none", "name": "NPLOC4:UFD1L:VCP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10646311", "map_id": "none", "name": "SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646333", "map_id": "none", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646309", "map_id": "Q22557", "name": "dvc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10646357", "map_id": "none", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10646354", "map_id": "none", "name": "PCNA:RPA:RFC:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10646094", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10648209", "map_id": "none", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648199", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_68454", "map_id": "none", "name": "Flap", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648206", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648197", "map_id": "none", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648186", "map_id": "none", "name": "Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0FLQ6", "map_id": "A0FLQ6", "name": "polq-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020964", "map_id": "WBGene00020964", "name": "polq-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10648194", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648188", "map_id": "none", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648170", "map_id": "none", "name": "Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648180", "map_id": "none", "name": "POLQ homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648202", "map_id": "none", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10648173", "map_id": "none", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648166", "map_id": "none", "name": "DNA DSB:MRN:RBBP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10621613", "map_id": "none", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10621610", "map_id": "Q9N3C7", "name": "mod-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003387", "map_id": "WBGene00003387", "name": "mod-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617035", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10619309", "map_id": "none", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10619291", "map_id": "none", "name": "Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9GYJ9", "map_id": "Q9GYJ9", "name": "snx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004927", "map_id": "WBGene00004927", "name": "snx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55326", "map_id": "P55326", "name": "TPD52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008745", "map_id": "WBGene00008745", "name": "TPD52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45718", "map_id": "O45718", "name": "apb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000163", "map_id": "WBGene00000163", "name": "apb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBE2", "map_id": "G5EBE2", "name": "tbc-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012868", "map_id": "WBGene00012868", "name": "tbc-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02328", "map_id": "Q02328", "name": "hipr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022717", "map_id": "WBGene00022717", "name": "hipr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44445", "map_id": "O44445", "name": "snpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015327", "map_id": "WBGene00015327", "name": "snpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4E2", "map_id": "Q8I4E2", "name": "lst-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003086", "map_id": "WBGene00003086", "name": "lst-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C6KRN3", "map_id": "C6KRN3", "name": "YIPF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012208", "map_id": "WBGene00012208", "name": "YIPF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T874", "map_id": "Q8T874", "name": "aps-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000165", "map_id": "WBGene00000165", "name": "aps-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D9PTP5", "map_id": "D9PTP5", "name": "snx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013354", "map_id": "WBGene00013354", "name": "snx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WXP9", "map_id": "A0A486WXP9", "name": "dnj-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001043", "map_id": "WBGene00001043", "name": "dnj-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619307", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10619432", "map_id": "none", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619429", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10614994", "map_id": "none", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614986", "map_id": "none", "name": "Arf1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10614991", "map_id": "G5EGS5", "name": "gbf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10659242", "map_id": "none", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659237", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6AHQ8", "map_id": "Q6AHQ8", "name": "sdpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018467", "map_id": "WBGene00018467", "name": "sdpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19253", "map_id": "Q19253", "name": "toca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017298", "map_id": "WBGene00017298", "name": "toca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS7", "map_id": "Q9XUS7", "name": "toca-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010663", "map_id": "WBGene00010663", "name": "toca-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659239", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659406", "map_id": "none", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10659402", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10659248", "map_id": "A0A486WXP9", "name": "dnj-25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10659404", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10659195", "map_id": "none", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659118", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659177", "map_id": "none", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659167", "map_id": "none", "name": "FNBP1L dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659171", "map_id": "none", "name": "TRIP10 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10608681", "map_id": "none", "name": "SH3GLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659141", "map_id": "none", "name": "PACSIN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659143", "map_id": "Q8I4E2", "name": "lst-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10659124", "map_id": "none", "name": "AMPH:BIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659159", "map_id": "none", "name": "FNBP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658206", "map_id": "none", "name": "FCHO1,2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10633167", "map_id": "G5EDY0", "name": "piki-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10659175", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659192", "map_id": "none", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659116", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659179", "map_id": "none", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659114", "map_id": "none", "name": "CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10658232", "map_id": "none", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658218", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658220", "map_id": "Q9N489", "name": "ncap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10658191", "map_id": "none", "name": "Homologues of AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10658224", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10658230", "map_id": "none", "name": "ARFGAP1:ARF6:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10659190", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618288", "map_id": "O01759", "name": "ppk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10658243", "map_id": "none", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10659244", "map_id": "none", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659225", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659409", "map_id": "none", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10659815", "map_id": "none", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10658214", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659813", "map_id": "none", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10659811", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q9GYH7", "map_id": "Q9GYH7", "name": "rme-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004377", "map_id": "WBGene00004377", "name": "rme-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10659460", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10659221", "map_id": "none", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659211", "map_id": "none", "name": "HIP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659207", "map_id": "none", "name": "f-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10659215", "map_id": "none", "name": "HIP1R dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659217", "map_id": "none", "name": "ARP2/3 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659219", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10659227", "map_id": "none", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10659223", "map_id": "none", "name": "DNM:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10644197", "map_id": "none", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644194", "map_id": "none", "name": "LTCC multimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10644705", "map_id": "none", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10644685", "map_id": "none", "name": "Homologues of TNNI3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44572", "map_id": "O44572", "name": "phospho-tni-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006586", "map_id": "WBGene00006586", "name": "phospho-tni-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20334", "map_id": "Q20334", "name": "phospho-tni-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006584", "map_id": "WBGene00006584", "name": "phospho-tni-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYF1", "map_id": "Q9GYF1", "name": "phospho-unc-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006764", "map_id": "WBGene00006764", "name": "phospho-unc-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUN9", "map_id": "Q9XUN9", "name": "phospho-tni-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006585", "map_id": "WBGene00006585", "name": "phospho-tni-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10644703", "map_id": "none", "name": "Homologues of p-S23,S24-TNNI3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619072", "map_id": "none", "name": "Nectin-1:Nectin-4 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10618983", "map_id": "none", "name": "Nectin cis-homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EG33", "map_id": "G5EG33", "name": "him-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001863", "map_id": "WBGene00001863", "name": "him-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619068", "map_id": "none", "name": "Nectin-4 cis homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619070", "map_id": "none", "name": "Nectin-1:Nectin-4 trans heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10619066", "map_id": "none", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10618975", "map_id": "G5EG33", "name": "him-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10611124", "map_id": "G5EG33", "name": "him-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10619064", "map_id": "none", "name": "PRV:PVRL3 trans heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10619062", "map_id": "none", "name": "Nectin-1:PVRL3 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10619058", "map_id": "none", "name": "PVRL3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619060", "map_id": "none", "name": "Nectin-1:PVRL3 trans heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10640549", "map_id": "none", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10612994", "map_id": "none", "name": "Integrin alpha6beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10640545", "map_id": "none", "name": "Laminin-211, 221, 332, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10640547", "map_id": "none", "name": "Integrin alpha6beta1:Laminin-211, 221, 332, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614501", "map_id": "none", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614495", "map_id": "none", "name": "Integrin alpha7beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614497", "map_id": "none", "name": "Laminin-211, 221, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10614499", "map_id": "none", "name": "Integrin alpha7beta1:Laminin-211, 221, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10640887", "map_id": "none", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10640883", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10640885", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5:HSPG2(22-4391)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10614473", "map_id": "none", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10614469", "map_id": "none", "name": "Laminins-332, 511, 521, (211, 221)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10614421", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10614471", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636750", "map_id": "none", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636746", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens 1,2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10636748", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10665322", "map_id": "none", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665189", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10665191", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665314", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665178", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665172", "map_id": "none", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665165", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10665169", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665311", "map_id": "none", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665309", "map_id": "none", "name": "FLCN:FNIP1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L0I8", "map_id": "H2L0I8", "name": "fnip-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020208", "map_id": "WBGene00020208", "name": "fnip-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "S6FMZ4", "map_id": "S6FMZ4", "name": "flcn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017699", "map_id": "WBGene00017699", "name": "flcn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10665185", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665180", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10665174", "map_id": "none", "name": "SLC38A9:L-Arg", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665187", "map_id": "none", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665176", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665183", "map_id": "none", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10665196", "map_id": "none", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10665193", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10665769", "map_id": "none", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649795", "map_id": "none", "name": "TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649806", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649828", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649814", "map_id": "none", "name": "TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649826", "map_id": "none", "name": "TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649798", "map_id": "none", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649784", "map_id": "none", "name": "TC-NER pre-incision complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649812", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649808", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604543", "map_id": "none", "name": "ERCC1:ERCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649810", "map_id": "none", "name": "TC-NER incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649817", "map_id": "none", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10618987", "map_id": "none", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10618985", "map_id": "none", "name": "Nectin trans homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10621121", "map_id": "none", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10618973", "map_id": "G5EG33", "name": "him-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10618981", "map_id": "none", "name": "Interaction of Nectins with Afadin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618971", "map_id": "Q86NJ4", "name": "afd-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021009", "map_id": "WBGene00021009", "name": "afd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618979", "map_id": "none", "name": "Nectin:afadin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86NJ4", "map_id": "Q86NJ4", "name": "afd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619084", "map_id": "none", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617173", "map_id": "Q20435", "name": "atf-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00000222", "map_id": "WBGene00000222", "name": "atf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619076", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617114", "map_id": "Q20435", "name": "atf-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10617118", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617116", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10617166", "map_id": "none", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617163", "map_id": "none", "name": "p-S52-EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617139", "map_id": "none", "name": "PERK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NAK3", "map_id": "Q9NAK3", "name": "EIF2AK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012586", "map_id": "WBGene00012586", "name": "EIF2AK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617156", "map_id": "none", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617148", "map_id": "none", "name": "IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q09499", "map_id": "Q09499", "name": "phospho-ire-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002147", "map_id": "WBGene00002147", "name": "phospho-ire-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617153", "map_id": "none", "name": "p-S724-IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617158", "map_id": "none", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617146", "map_id": "Q09499", "name": "ire-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10628857", "map_id": "none", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10628845", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10628851", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10628923", "map_id": "none", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628892", "map_id": "O02219", "name": "aha-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000095", "map_id": "WBGene00000095", "name": "aha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10628894", "map_id": "none", "name": "HIF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02219", "map_id": "O02219", "name": "aha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10639875", "map_id": "none", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639873", "map_id": "none", "name": "HSP70:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10639871", "map_id": "none", "name": "HSP40:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16303", "map_id": "O16303", "name": "dnj-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001037", "map_id": "WBGene00001037", "name": "dnj-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45502", "map_id": "O45502", "name": "dnj-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001030", "map_id": "WBGene00001030", "name": "dnj-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10639772", "map_id": "none", "name": "HSP40:HSP70:ATP:nascent protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617141", "map_id": "none", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617130", "map_id": "none", "name": "Homologues of EIF2AK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10628905", "map_id": "none", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10628903", "map_id": "none", "name": "HIF:CBP:p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10639777", "map_id": "none", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10639774", "map_id": "none", "name": "HSP40:HSP70:ADP:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10639770", "map_id": "none", "name": "HSP40s", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617181", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617177", "map_id": "Q20435", "name": "atf-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10617171", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10665100", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615353", "map_id": "none", "name": "Homologues of ACHE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10615850", "map_id": "none", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10660314", "map_id": "none", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane" }, { "id": "species_10660280", "map_id": "none", "name": "GGC-RAB1:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659955", "map_id": "none", "name": "GDIs,CHMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660290", "map_id": "none", "name": "GGC-RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "species_10660311", "map_id": "none", "name": "TRAPPCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5WRR4", "map_id": "Q5WRR4", "name": "trpp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016614", "map_id": "WBGene00016614", "name": "trpp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QQ2", "map_id": "Q95QQ2", "name": "TRAPPC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016964", "map_id": "WBGene00016964", "name": "TRAPPC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BI63", "map_id": "Q9BI63", "name": "trpp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018512", "map_id": "WBGene00018512", "name": "trpp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10659968", "map_id": "none", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane" }, { "id": "species_10659957", "map_id": "none", "name": "GGC-RAB3A:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10659961", "map_id": "none", "name": "GGC-RAB3A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10659965", "map_id": "none", "name": "RAB3 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02626", "map_id": "O02626", "name": "aex-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000086", "map_id": "WBGene00000086", "name": "aex-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660750", "map_id": "none", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660324", "map_id": "Q7K7A5", "name": "rme-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004375", "map_id": "WBGene00004375", "name": "rme-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10660745", "map_id": "Q7K7A5", "name": "phospho-rme-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10660061", "map_id": "none", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10660045", "map_id": "none", "name": "GGC-RAB10:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660049", "map_id": "none", "name": "GGC-RAB10:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10660054", "map_id": "U4PBM1", "name": "denn-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018681", "map_id": "WBGene00018681", "name": "denn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660203", "map_id": "none", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10660192", "map_id": "none", "name": "GGC-RAB21:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660196", "map_id": "none", "name": "GGC-RAB21:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10660198", "map_id": "Q9TXP3", "name": "mtm-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10660096", "map_id": "none", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10660085", "map_id": "none", "name": "GGC-RAB6:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660093", "map_id": "none", "name": "GGC-RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10657253", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660170", "map_id": "none", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660154", "map_id": "none", "name": "GGC-RAB14:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660158", "map_id": "none", "name": "GGC-RAB14:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10660167", "map_id": "none", "name": "DENND6A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45074", "map_id": "O45074", "name": "DENND6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018777", "map_id": "WBGene00018777", "name": "DENND6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660377", "map_id": "none", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10660361", "map_id": "none", "name": "GGC-RAB39:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660367", "map_id": "none", "name": "GGC-RAB39:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10660372", "map_id": "Q18780", "name": "lst-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016889", "map_id": "WBGene00016889", "name": "lst-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660123", "map_id": "none", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10660114", "map_id": "none", "name": "GCC-RAB12:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660118", "map_id": "none", "name": "GGC-RAB12:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10660120", "map_id": "none", "name": "DENND3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "U4PBM1", "map_id": "U4PBM1", "name": "denn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660329", "map_id": "none", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10660318", "map_id": "none", "name": "GGC-RAB35:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660322", "map_id": "none", "name": "GGC-RAB35:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "reaction_10660406", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10660393", "map_id": "none", "name": "GGC-RAB18:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660397", "map_id": "none", "name": "GGC-RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10660403", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660150", "map_id": "none", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10660141", "map_id": "none", "name": "GGC-RAB13:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660145", "map_id": "none", "name": "GGC-RAB13:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "species_10660147", "map_id": "none", "name": "RAB13 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K7A5", "map_id": "Q7K7A5", "name": "rme-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660245", "map_id": "none", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10660232", "map_id": "none", "name": "GGC-RAB27:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660242", "map_id": "none", "name": "RAB27:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10645717", "map_id": "O02626", "name": "aex-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10660272", "map_id": "none", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10660249", "map_id": "none", "name": "GGC-RAB7:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660255", "map_id": "none", "name": "GGC-RAB7:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10660269", "map_id": "none", "name": "MON1:CCZ1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BI89", "map_id": "Q9BI89", "name": "sand-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018321", "map_id": "WBGene00018321", "name": "sand-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVL8", "map_id": "Q9XVL8", "name": "ccz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010283", "map_id": "WBGene00010283", "name": "ccz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10660081", "map_id": "none", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10660065", "map_id": "none", "name": "GGC-RAB8:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10660071", "map_id": "none", "name": "GGC-RAB8:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10660078", "map_id": "none", "name": "RAB8 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10660110", "map_id": "none", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10660103", "map_id": "U4PBM1", "name": "denn-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10660107", "map_id": "U4PBM1", "name": "phospho-denn-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10646852", "map_id": "none", "name": "Homologues of p-T180,S317,S467,S556,S638,T575-ULK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620770", "map_id": "none", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620720", "map_id": "U4PBJ9", "name": "fln-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620753", "map_id": "Q9U3F4", "name": "zyx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006999", "map_id": "WBGene00006999", "name": "zyx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620768", "map_id": "none", "name": "Migfilin:Filamin A:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U3F4", "map_id": "Q9U3F4", "name": "zyx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622043", "map_id": "none", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10622041", "map_id": "none", "name": "Integrin alpha6:beta4:Plectin:BP180 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621032", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622187", "map_id": "none", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622183", "map_id": "G5EG53", "name": "unc-34", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006770", "map_id": "WBGene00006770", "name": "unc-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622185", "map_id": "none", "name": "MIGFILIN:VASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EG53", "map_id": "G5EG53", "name": "unc-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621040", "map_id": "none", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10621036", "map_id": "none", "name": "BP230", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10621038", "map_id": "none", "name": "BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620762", "map_id": "none", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620758", "map_id": "Q18685", "name": "unc-112", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620760", "map_id": "none", "name": "MIG-2:MIGFILIN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621020", "map_id": "none", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612261", "map_id": "Q27874", "name": "pat-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10621016", "map_id": "Q9TZC4", "name": "pat-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003931", "map_id": "WBGene00003931", "name": "pat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621018", "map_id": "none", "name": "ILK:Integrin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TZC4", "map_id": "Q9TZC4", "name": "pat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622206", "map_id": "none", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622200", "map_id": "none", "name": "alpha/beta parvin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622198", "map_id": "none", "name": "PINCH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19157", "map_id": "Q19157", "name": "pin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004030", "map_id": "WBGene00004030", "name": "pin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622204", "map_id": "none", "name": "PINCH-ILK-parvin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622039", "map_id": "none", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622035", "map_id": "P34285", "name": "tsp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006627", "map_id": "WBGene00006627", "name": "tsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622037", "map_id": "none", "name": "CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34285", "map_id": "P34285", "name": "tsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621024", "map_id": "none", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10614419", "map_id": "none", "name": "Integrin alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10611919", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621022", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609990", "map_id": "none", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10609944", "map_id": "U4PBY2", "name": "hum-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10609988", "map_id": "none", "name": "Invaginating gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10609992", "map_id": "none", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10603861", "map_id": "none", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10605290", "map_id": "none", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10609645", "map_id": "none", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189075", "map_id": "none", "name": "starch (amylose)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10609642", "map_id": "P91982", "name": "AMY2A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00008220", "map_id": "WBGene00008220", "name": "AMY2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10609687", "map_id": "none", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188973", "map_id": "CHEBI:17716", "name": "Lac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10609684", "map_id": "none", "name": "LCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10609670", "map_id": "none", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10609667", "map_id": "none", "name": "sucrase-isomaltase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19004", "map_id": "Q19004", "name": "aagr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017071", "map_id": "WBGene00017071", "name": "aagr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10646409", "map_id": "none", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5659875", "map_id": "CHEBI:28189", "name": "iMal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10609994", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10609690", "map_id": "none", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188980", "map_id": "CHEBI:17992", "name": "Suc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10650244", "map_id": "none", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6786438", "map_id": "none", "name": "chitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_6786428", "map_id": "CHEBI:86361", "name": "GlcNAc-beta1,4-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6786426", "map_id": "CHEBI:86362", "name": "GlcNAc-beta1,4-GlcNAc-beta1,4-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10650241", "map_id": "Q965P2", "name": "cht-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00021252", "map_id": "WBGene00021252", "name": "cht-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10609998", "map_id": "none", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189071", "map_id": "none", "name": "starch (amylopectin)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10609697", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10609694", "map_id": "none", "name": "MGAM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10610000", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10609996", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10648681", "map_id": "none", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648674", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648678", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648331", "map_id": "none", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648306", "map_id": "Q21302", "name": "xpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10648325", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648329", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648692", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10648689", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10648685", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10648687", "map_id": "none", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10604545", "map_id": "none", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604541", "map_id": "G5EBZ1", "name": "xpf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604536", "map_id": "Q93456", "name": "ercc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10637467", "map_id": "none", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10637463", "map_id": "none", "name": "Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10637465", "map_id": "none", "name": "TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10637471", "map_id": "none", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636719", "map_id": "none", "name": "Tenascins C, R, (X, N)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q5ZR75", "map_id": "Q5ZR75", "name": "TNR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020516", "map_id": "WBGene00020516", "name": "TNR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10637469", "map_id": "none", "name": "Tenascins C, R, (X, N):Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10636627", "map_id": "none", "name": "HSPG2 (perlecan) binds alpha-dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10636625", "map_id": "none", "name": "HSPG2:Dystroglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636875", "map_id": "none", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10636871", "map_id": "none", "name": "Beta amyloid fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10636867", "map_id": "O44565", "name": "lam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10636873", "map_id": "none", "name": "AGRN:Beta amyloid fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10649760", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649737", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649757", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649741", "map_id": "none", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649724", "map_id": "Q86D18", "name": "ERCC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10649716", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10649726", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649787", "map_id": "none", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649778", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649714", "map_id": "none", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649712", "map_id": "none", "name": "Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10649719", "map_id": "none", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6781829", "map_id": "CHEBI:17972", "name": "ribonucleoside triphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10649739", "map_id": "none", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10649735", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10637202", "map_id": "none", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10636530", "map_id": "none", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10636528", "map_id": "none", "name": "Integrin alpha5beta1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10657257", "map_id": "none", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10657247", "map_id": "none", "name": "RAB33B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10657255", "map_id": "none", "name": "RAB33B:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10656786", "map_id": "none", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10656221", "map_id": "none", "name": "COG complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10656782", "map_id": "none", "name": "other COG interacting snares", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "H2KYN0", "map_id": "H2KYN0", "name": "vps-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016643", "map_id": "WBGene00016643", "name": "vps-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10656784", "map_id": "none", "name": "COG complex:Golgi snares", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10657525", "map_id": "none", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10657521", "map_id": "none", "name": "other COG-interacting RABs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10657523", "map_id": "none", "name": "COG complex:RABs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10657238", "map_id": "none", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10657234", "map_id": "none", "name": "STX:PalmC-YKT6:BET1L:GOSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10657236", "map_id": "none", "name": "STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10623845", "map_id": "none", "name": "Nephrin mediated activation of N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623841", "map_id": "none", "name": "NEPH1:p-Nephrin:Fyn:NCK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TXI8", "map_id": "Q9TXI8", "name": "phospho-igcm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018215", "map_id": "WBGene00018215", "name": "phospho-igcm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623843", "map_id": "none", "name": "NEPH1:p-Nephrin:Fyn:NCK:N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615502", "map_id": "none", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10615464", "map_id": "Q9TXI8", "name": "igcm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10615466", "map_id": "none", "name": "NPHS1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10636526", "map_id": "none", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605942", "species_10601226" ], "products": [ "species_10602837", "species_10602815", "species_10605946" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00002061", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10646047": { "compartment": "compartment_7660", "id": "reaction_10646047", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604739" ], "products": [ "species_10646044" ], "modifiers": [ [ "species_10604739", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604733": { "compartment": "compartment_7660", "id": "reaction_10604733", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10604730" ], "products": [ "species_10604726", "species_113541" ], "modifiers": [ [ "species_10604730", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604741": { "compartment": "compartment_7660", "id": "reaction_10604741", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604737", "species_10598275" ], "products": [ "species_10604739" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10639098": { "compartment": "compartment_70101", "id": "reaction_10639098", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639084" ], "products": [ "species_10639086" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639106": { "compartment": "compartment_70101", "id": "reaction_10639106", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639104", "species_113592" ], "products": [ "species_29370", "species_10639084" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639096": { "compartment": "compartment_70101", "id": "reaction_10639096", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639086" ], "products": [ "species_10639094" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10659999": { "compartment": "compartment_876", "id": "reaction_10659999", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10659994", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659992": { "compartment": "compartment_70101", "id": "reaction_10659992", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657701", "species_10617312" ], "products": [ "species_10659990" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659996": { "compartment": "compartment_70101", "id": "reaction_10659996", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10607816" ], "products": [ "species_10659994" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00021320", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660005": { "compartment": "compartment_70101", "id": "reaction_10660005", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10660001" ], "products": [ "species_10660003" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q20487", "WBGene00018520", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660008": { "compartment": "compartment_70101", "id": "reaction_10660008", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10660003", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10614891": { "compartment": "compartment_7660", "id": "reaction_10614891", "reactome": "R-CEL-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10614881" ], "products": [ "species_113582", "species_10614552" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00003917", "WBGene00000227" ] }, "reaction_10614556": { "compartment": "compartment_13231", "id": "reaction_10614556", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614552" ], "products": [ "species_10614554" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10614561": { "compartment": "compartment_70101", "id": "reaction_10614561", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614554", "species_10597908" ], "products": [ "species_10614558" ], "modifiers": [ [ "species_10614554", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00006727", "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00003917" ] }, "reaction_10598360": { "compartment": "compartment_7660", "id": "reaction_10598360", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598355", "species_10598298" ], "products": [ "species_10598357" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10609600": { "compartment": "compartment_7660", "id": "reaction_10609600", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_10598355" ], "products": [ "species_10609593" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517" ] }, "reaction_10614563": { "compartment": "compartment_70101", "id": "reaction_10614563", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614558" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10644160": { "compartment": "compartment_70101", "id": "reaction_10644160", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10644150": { "compartment": "compartment_984", "id": "reaction_10644150", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "CHEBI:78587", "CHEBI:78581", "CHEBI:78579", "CHEBI:78584", "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10644111": { "compartment": "compartment_70101", "id": "reaction_10644111", "reactome": "R-CEL-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605853": { "compartment": "compartment_70101", "id": "reaction_10605853", "reactome": "R-CEL-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10622150": { "compartment": "compartment_12045", "id": "reaction_10622150", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10622147", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10656532": { "compartment": "compartment_70101", "id": "reaction_10656532", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29356" ], "products": [ "species_109402", "species_29548" ], "modifiers": [ [ "species_10656529", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10625950": { "compartment": "compartment_70101", "id": "reaction_10625950", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10625945" ], "products": [ "species_10625947", "species_29370" ], "modifiers": [ [ "species_10625945", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625929": { "compartment": "compartment_70101", "id": "reaction_10625929", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625926" ], "products": [ "species_10625911" ], "modifiers": [ [ "species_10625926", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q93594", "WBGene00009141", "Q09543", "WBGene00003901", "Q9BL68", "WBGene00004884", "O01763", "WBGene00018156", "G5EGK8", "WBGene00002363", "A0A486WX07", "WBGene00002066", "G5EDR3", "WBGene00006352", "D0G912", "WBGene00194816", "O76512", "WBGene00004880", "Q9U302", "WBGene00003902", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10665669": { "compartment": "compartment_17947", "id": "reaction_10665669", "reactome": "R-CEL-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665661" ], "products": [ "species_10665667" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665338": { "compartment": "compartment_18667", "id": "reaction_10665338", "reactome": "R-CEL-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665330" ], "products": [ "species_10665336", "species_10616991", "species_10656088" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "Q22799", "WBGene00001005", "P30644", "WBGene00015264", "species_29420", "Q18817", "WBGene00000248", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q11083", "WBGene00015264", "G5ED34", "WBGene00001007", "H2L2E8", "WBGene00006528", "species_29438", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005" ] }, "reaction_10665685": { "compartment": "compartment_70101", "id": "reaction_10665685", "reactome": "R-CEL-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665651", "species_10642212" ], "products": [ "species_10665653" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "WBGene00015552", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10642254": { "compartment": "compartment_70101", "id": "reaction_10642254", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642201", "species_10642207", "species_10642195", "species_10642193", "species_10642212" ], "products": [ "species_10642214" ], "modifiers": [], "additional_components": [ "WBGene00008236", "WBGene00019900", "WBGene00001509", "WBGene00001509", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665641": { "compartment": "compartment_70101", "id": "reaction_10665641", "reactome": "R-CEL-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665637", "species_10664317" ], "products": [ "species_10665639" ], "modifiers": [], "additional_components": [ "WBGene00000227", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665679": { "compartment": "compartment_17947", "id": "reaction_10665679", "reactome": "R-CEL-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665675" ], "products": [ "species_10665677" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10665657": { "compartment": "compartment_17947", "id": "reaction_10665657", "reactome": "R-CEL-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665653" ], "products": [ "species_10665655" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10662842": { "compartment": "compartment_21994", "id": "reaction_10662842", "reactome": "R-CEL-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662838", "species_10642246" ], "products": [ "species_10662840" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q22252", "WBGene00011528", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q23536", "WBGene00002981", "Q10931", "WBGene00002982", "Q22252", "WBGene00011528" ] }, "reaction_10642225": { "compartment": "compartment_70101", "id": "reaction_10642225", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10642214" ], "products": [ "species_10642223" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q23536", "WBGene00002981", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665671": { "compartment": "compartment_17947", "id": "reaction_10665671", "reactome": "R-CEL-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665643", "species_10665659" ], "products": [ "species_10665661" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "WBGene00000227", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10662844": { "compartment": "compartment_70101", "id": "reaction_10662844", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10661490" ], "products": [ "species_10662838" ], "modifiers": [], "additional_components": [ "WBGene00002981", "WBGene00011528", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10661493": { "compartment": "compartment_17906", "id": "reaction_10661493", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661490" ], "modifiers": [ [ "species_10661471", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10665228": { "compartment": "compartment_70101", "id": "reaction_10665228", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665220", "species_10665224" ], "products": [ "species_10665226" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642252": { "compartment": "compartment_17906", "id": "reaction_10642252", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642230" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665284": { "compartment": "compartment_70101", "id": "reaction_10665284", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665226" ], "products": [ "species_10665282" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10661481": { "compartment": "compartment_70101", "id": "reaction_10661481", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661463" ], "products": [ "species_10661460" ], "modifiers": [ [ "species_10661478", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10661465": { "compartment": "compartment_70101", "id": "reaction_10661465", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661463" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665286": { "compartment": "compartment_70101", "id": "reaction_10665286", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665282" ], "products": [ "species_10665256" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "O45495", "WBGene00006730", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642258": { "compartment": "compartment_17927", "id": "reaction_10642258", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642256" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665683": { "compartment": "compartment_17947", "id": "reaction_10665683", "reactome": "R-CEL-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665667" ], "products": [ "species_10665651" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661487": { "compartment": "compartment_70101", "id": "reaction_10661487", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661463" ], "products": [ "species_29370", "species_10661484" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00005077" ] }, "reaction_10665320": { "compartment": "compartment_70101", "id": "reaction_10665320", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665316", "species_10656088" ], "products": [ "species_10665318" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "O45087", "WBGene00015927", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "G5ED34", "WBGene00001007", "Q22799", "WBGene00001005", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885" ] }, "reaction_10665681": { "compartment": "compartment_70101", "id": "reaction_10665681", "reactome": "R-CEL-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665639" ], "products": [ "species_10665659" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661473": { "compartment": "compartment_17906", "id": "reaction_10661473", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646604" ], "products": [ "species_10661471" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10624305": { "compartment": "compartment_876", "id": "reaction_10624305", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10624302", "catalyst" ] ], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10624483": { "compartment": "compartment_984", "id": "reaction_10624483", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624300", "species_372533" ], "products": [ "species_10624302" ], "modifiers": [], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "Q93323", "WBGene00007903", "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10656521": { "compartment": "compartment_172574", "id": "reaction_10656521", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656517" ], "products": [ "species_10656519" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10656524": { "compartment": "compartment_7660", "id": "reaction_10656524", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_113550", "species_6810408" ], "modifiers": [ [ "species_10656519", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10656818": { "compartment": "compartment_7660", "id": "reaction_10656818", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10656815", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10611022": { "compartment": "compartment_7660", "id": "reaction_10611022", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10607257", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664813": { "compartment": "compartment_70101", "id": "reaction_10664813", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607886" ], "products": [ "species_10611039" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664806": { "compartment": "compartment_70101", "id": "reaction_10664806", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664792", "species_113592" ], "products": [ "species_29370", "species_10664801" ], "modifiers": [ [ "species_10664792", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10664790": { "compartment": "compartment_74700", "id": "reaction_10664790", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10664786", "species_10647064" ], "products": [ "species_10664788" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10612228": { "compartment": "compartment_876", "id": "reaction_10612228", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10605404" ], "products": [ "species_10612226" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10664854": { "compartment": "compartment_7660", "id": "reaction_10664854", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664849", "species_29358" ], "products": [ "species_113582", "species_10664852" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10611305": { "compartment": "compartment_7660", "id": "reaction_10611305", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611302", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10664811": { "compartment": "compartment_74700", "id": "reaction_10664811", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664808" ], "products": [ "species_29370", "species_10664786" ], "modifiers": [ [ "species_10664808", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10611033": { "compartment": "compartment_7660", "id": "reaction_10611033", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611029" ], "products": [ "species_10611031" ], "modifiers": [], "additional_components": [ "WBGene00004859", "WBGene00004859" ] }, "reaction_10611296": { "compartment": "compartment_7660", "id": "reaction_10611296", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611290" ], "products": [ "species_113582", "species_10611293" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10611307": { "compartment": "compartment_7660", "id": "reaction_10611307", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10664803": { "compartment": "compartment_70101", "id": "reaction_10664803", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664801" ], "products": [ "species_10618752", "species_10647089", "species_10664786" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10664844": { "compartment": "compartment_7660", "id": "reaction_10664844", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10607457": { "compartment": "compartment_876", "id": "reaction_10607457", "reactome": "R-CEL-169904", "name": "C3G stimulates nucleotide exchange on Rap1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607452" ], "products": [ "species_10607454", "species_29420" ], "modifiers": [ [ "species_10607443", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10612373": { "compartment": "compartment_7660", "id": "reaction_10612373", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10612370", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10607466": { "compartment": "compartment_876", "id": "reaction_10607466", "reactome": "R-CEL-169905", "name": "ARMS is phosphorylated by active TrkA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607463" ], "products": [ "species_29370", "species_10607443" ], "modifiers": [ [ "species_10607463", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10607846": { "compartment": "compartment_876", "id": "reaction_10607846", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10607842" ], "products": [ "species_10607844" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017891", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10647187": { "compartment": "compartment_70101", "id": "reaction_10647187", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618752" ], "products": [ "species_10607886" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10607820": { "compartment": "compartment_74700", "id": "reaction_10607820", "reactome": "R-CEL-170978", "name": "p-FRS2:CRKL binds C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607816", "species_10607811" ], "products": [ "species_10607818" ], "modifiers": [], "additional_components": [ "WBGene00021320", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "E6N0V1", "WBGene00018819", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "H2KZX7", "WBGene00021320", "E6N0V1", "WBGene00018819" ] }, "reaction_10664799": { "compartment": "compartment_74700", "id": "reaction_10664799", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664788", "species_113592" ], "products": [ "species_10664792", "species_29370" ], "modifiers": [ [ "species_10664788", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10609591": { "compartment": "compartment_70101", "id": "reaction_10609591", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609556" ], "products": [ "species_29370", "species_10609574" ], "modifiers": [ [ "species_10609588", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496" ] }, "reaction_10611336": { "compartment": "compartment_7660", "id": "reaction_10611336", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10611333", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "A9UJN4", "WBGene00007554", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10607445": { "compartment": "compartment_984", "id": "reaction_10607445", "reactome": "R-CEL-169895", "name": "Crk's SH3 domain engages C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607443" ], "products": [ "species_10607443" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10611042": { "compartment": "compartment_7660", "id": "reaction_10611042", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10611039", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664875": { "compartment": "compartment_7660", "id": "reaction_10664875", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640193", "species_10664859", "species_10664871" ], "products": [ "species_10664873" ], "modifiers": [], "additional_components": [ "WBGene00002637", "WBGene00003107", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "U4PBA8", "WBGene00043705", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22002", "WBGene00003107", "U4PBA8", "WBGene00043705" ] }, "reaction_10637627": { "compartment": "compartment_876", "id": "reaction_10637627", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10614487" ], "products": [ "species_10637625" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10637623": { "compartment": "compartment_876", "id": "reaction_10637623", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10637619" ], "products": [ "species_10637621" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "P50605", "WBGene00004749" ] }, "reaction_10637924": { "compartment": "compartment_876", "id": "reaction_10637924", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637920", "species_10618504" ], "products": [ "species_10637922" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10637535": { "compartment": "compartment_876", "id": "reaction_10637535", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10609836" ], "products": [ "species_10637533" ], "modifiers": [], "additional_components": [ "WBGene00004749", "WBGene00002881", "Q11184", "WBGene00002881", "P50605", "WBGene00004749" ] }, "reaction_10638478": { "compartment": "compartment_70101", "id": "reaction_10638478", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638466", "species_3134861" ], "products": [ "species_10638468" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10638476": { "compartment": "compartment_70101", "id": "reaction_10638476", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638470", "species_3134861" ], "products": [ "species_10638472" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10622778": { "compartment": "compartment_876", "id": "reaction_10622778", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622774", "species_210382" ], "products": [ "species_10622776" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006", "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10622781": { "compartment": "compartment_70101", "id": "reaction_10622781", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10622776", "catalyst" ] ], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10598836": { "compartment": "compartment_70101", "id": "reaction_10598836", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10598833", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10598710": { "compartment": "compartment_5460", "id": "reaction_10598710", "reactome": "R-CEL-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10598707", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "WBGene00004259" ] }, "reaction_10622848": { "compartment": "compartment_5460", "id": "reaction_10622848", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10622845", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10598720": { "compartment": "compartment_70101", "id": "reaction_10598720", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10598717", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10607315": { "compartment": "compartment_7660", "id": "reaction_10607315", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607308" ], "products": [ "species_113582", "species_10607312" ], "modifiers": [ [ "species_10607290", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10607375": { "compartment": "compartment_7660", "id": "reaction_10607375", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_10607312" ], "products": [ "species_10607373" ], "modifiers": [], "additional_components": [ "WBGene00000223", "WBGene00012005", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10622474": { "compartment": "compartment_70101", "id": "reaction_10622474", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622458" ], "products": [ "species_10622472" ], "modifiers": [], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607371": { "compartment": "compartment_70101", "id": "reaction_10607371", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607329" ], "products": [ "species_29370", "species_10607343" ], "modifiers": [ [ "species_10607368", "catalyst" ] ], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "O01706", "WBGene00012162", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10622491": { "compartment": "compartment_7660", "id": "reaction_10622491", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622488" ], "products": [ "species_113582", "species_10622403" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607303": { "compartment": "compartment_7660", "id": "reaction_10607303", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607226" ], "products": [ "species_113582", "species_10607230" ], "modifiers": [ [ "species_10607300", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "P39745", "WBGene00003401", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "Q17446", "WBGene00004055", "U4PDY6", "WBGene00019665" ] }, "reaction_10622517": { "compartment": "compartment_70101", "id": "reaction_10622517", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343" ], "products": [ "species_10607290" ], "modifiers": [], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10622418": { "compartment": "compartment_7660", "id": "reaction_10622418", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622403" ], "products": [ "species_113582", "species_10622415" ], "modifiers": [ [ "species_10622403", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10622422": { "compartment": "compartment_70101", "id": "reaction_10622422", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622415" ], "products": [ "species_10622420" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10628646": { "compartment": "compartment_70101", "id": "reaction_10628646", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628641" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628643" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00022048", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "U4PBJ9", "WBGene00022048", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10625395": { "compartment": "compartment_13231", "id": "reaction_10625395", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625381" ], "products": [ "species_10625389", "species_10625393", "species_10625391" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00002075", "WBGene00009956" ] }, "reaction_10628669": { "compartment": "compartment_70101", "id": "reaction_10628669", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628665" ], "products": [ "species_10627823", "species_10628632", "species_10628667", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10663507": { "compartment": "compartment_70101", "id": "reaction_10663507", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8983696", "species_29356" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10663504", "catalyst" ] ], "additional_components": [ "species_113592", "WBGene00011268" ] }, "reaction_10633391": { "compartment": "compartment_70101", "id": "reaction_10633391", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628679" ], "products": [ "species_141681", "species_10628677" ], "modifiers": [ [ "species_10633388", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "Q22240", "WBGene00011507" ] }, "reaction_10633412": { "compartment": "compartment_70101", "id": "reaction_10633412", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633398", "species_10633408" ], "products": [ "species_10633410", "species_10633406" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10666093": { "compartment": "compartment_70101", "id": "reaction_10666093", "reactome": "R-CEL-9710963", "name": "p-STAT1dimer:KPNA1 binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666087", "species_10614210" ], "products": [ "species_10666091" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "WBGene00002075", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628681": { "compartment": "compartment_70101", "id": "reaction_10628681", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628677", "species_10628634", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628679" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006713", "WBGene00016158", "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10666089": { "compartment": "compartment_70101", "id": "reaction_10666089", "reactome": "R-CEL-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614205", "species_10625312" ], "products": [ "species_10666087" ], "modifiers": [], "additional_components": [ "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628650": { "compartment": "compartment_70101", "id": "reaction_10628650", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_10627458" ], "products": [ "species_10628648" ], "modifiers": [], "additional_components": [ "WBGene00018660", "WBGene00022358", "O44820", "WBGene00018660", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10633414": { "compartment": "compartment_70101", "id": "reaction_10633414", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10633396" ], "products": [ "species_10633398" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00002062", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158" ] }, "reaction_10625031": { "compartment": "compartment_13231", "id": "reaction_10625031", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625021" ], "products": [ "species_10625029" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628639": { "compartment": "compartment_70101", "id": "reaction_10628639", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_113592", "species_10627828" ], "products": [ "species_111294", "species_10628636", "species_76577" ], "modifiers": [ [ "species_10627828", "catalyst" ] ], "additional_components": [ "WBGene00018660", "WBGene00006699", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "WBGene00006699" ] }, "reaction_10628659": { "compartment": "compartment_70101", "id": "reaction_10628659", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627823", "species_10628636" ], "products": [ "species_10628627", "species_10627828" ], "modifiers": [ [ "species_10627823", "catalyst" ] ], "additional_components": [ "WBGene00006713", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "WBGene00006699", "WBGene00006713" ] }, "reaction_10628654": { "compartment": "compartment_70101", "id": "reaction_10628654", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10612207", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_10628652", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006708", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "Q95XX0", "WBGene00006708", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10628656": { "compartment": "compartment_70101", "id": "reaction_10628656", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628632", "species_10628627" ], "products": [ "species_10628634" ], "modifiers": [], "additional_components": [ "WBGene00016158", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10657691": { "compartment": "compartment_17963", "id": "reaction_10657691", "reactome": "R-CEL-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657686" ], "products": [ "species_10609860" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00002881" ] }, "reaction_10646301": { "compartment": "compartment_70101", "id": "reaction_10646301", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636505", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646280": { "compartment": "compartment_70101", "id": "reaction_10646280", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646277", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646291": { "compartment": "compartment_70101", "id": "reaction_10646291", "reactome": "R-CEL-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608561", "species_10636509" ], "products": [ "species_10636511" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646246": { "compartment": "compartment_984", "id": "reaction_10646246", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646242", "species_190915" ], "products": [ "species_10646244" ], "modifiers": [], "additional_components": [ "WBGene00002181", "G5EDX1", "WBGene00002181", "species_190915" ] }, "reaction_10646181": { "compartment": "compartment_70101", "id": "reaction_10646181", "reactome": "R-CEL-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646176", "species_113592" ], "products": [ "species_10646178", "species_29370" ], "modifiers": [ [ "species_10646176", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646260": { "compartment": "compartment_876", "id": "reaction_10646260", "reactome": "R-CEL-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10636501" ], "modifiers": [ [ "species_10646248", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646204": { "compartment": "compartment_70101", "id": "reaction_10646204", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646201", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646197": { "compartment": "compartment_70101", "id": "reaction_10646197", "reactome": "R-CEL-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646194", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646267": { "compartment": "compartment_70101", "id": "reaction_10646267", "reactome": "R-CEL-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646192" ], "products": [ "species_10646194" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646298": { "compartment": "compartment_70101", "id": "reaction_10646298", "reactome": "R-CEL-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646289" ], "products": [ "species_10646293" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646265": { "compartment": "compartment_876", "id": "reaction_10646265", "reactome": "R-CEL-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646262" ], "products": [ "species_29370", "species_10646190" ], "modifiers": [ [ "species_10646262", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10657689": { "compartment": "compartment_17963", "id": "reaction_10657689", "reactome": "R-CEL-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10657684" ], "products": [ "species_205687", "species_10657686" ], "modifiers": [ [ "species_10625450", "catalyst" ] ], "additional_components": [ "WBGene00002881", "WBGene00002881", "P34678", "WBGene00001628", "O61394", "WBGene00001631" ] }, "reaction_10608563": { "compartment": "compartment_70101", "id": "reaction_10608563", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10608459" ], "products": [ "species_10608561" ], "modifiers": [], "additional_components": [ "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646269": { "compartment": "compartment_70101", "id": "reaction_10646269", "reactome": "R-CEL-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636501", "species_10608561" ], "products": [ "species_10636503" ], "modifiers": [], "additional_components": [ "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646253": { "compartment": "compartment_70101", "id": "reaction_10646253", "reactome": "R-CEL-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10646250" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10646174": { "compartment": "compartment_70101", "id": "reaction_10646174", "reactome": "R-CEL-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646169" ], "products": [ "species_29370", "species_10646171" ], "modifiers": [ [ "species_10646169", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646255": { "compartment": "compartment_70101", "id": "reaction_10646255", "reactome": "R-CEL-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10646221" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10655619": { "compartment": "compartment_7660", "id": "reaction_10655619", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599987", "species_10655615", "species_10600001" ], "products": [ "species_10655617" ], "modifiers": [], "additional_components": [ "WBGene00004207", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q4W5P0", "WBGene00022235", "P34541", "WBGene00019881", "Q9U3I0", "WBGene00009078", "Q18999", "WBGene00004207", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q4W5P0", "WBGene00022235", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "P34541", "WBGene00019881", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10646223": { "compartment": "compartment_876", "id": "reaction_10646223", "reactome": "R-CEL-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10636509" ], "modifiers": [ [ "species_10646208", "catalyst" ], [ "species_10646221", "inhibitor" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646287": { "compartment": "compartment_876", "id": "reaction_10646287", "reactome": "R-CEL-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646282" ], "products": [ "species_29370", "species_10646284" ], "modifiers": [ [ "species_10646282", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646296": { "compartment": "compartment_70101", "id": "reaction_10646296", "reactome": "R-CEL-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646293", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646237": { "compartment": "compartment_876", "id": "reaction_10646237", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646233", "species_10646231", "species_190915" ], "products": [ "species_10646235" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881", "Q95XJ7", "WBGene00022418", "Q95XJ7", "WBGene00022418", "species_190915", "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881" ] }, "reaction_10646304": { "compartment": "compartment_70101", "id": "reaction_10646304", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636513", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10638456": { "compartment": "compartment_70101", "id": "reaction_10638456", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638454" ], "products": [ "species_10638452" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10632792": { "compartment": "compartment_70101", "id": "reaction_10632792", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10632789", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10632759": { "compartment": "compartment_70101", "id": "reaction_10632759", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10664432": { "compartment": "compartment_5460", "id": "reaction_10664432", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664428" ], "products": [ "species_10639552", "species_1655881", "species_10663602" ], "modifiers": [], "additional_components": [ "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307", "WBGene00007099", "WBGene00011307" ] }, "reaction_10663852": { "compartment": "compartment_5460", "id": "reaction_10663852", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10632779": { "compartment": "compartment_70101", "id": "reaction_10632779", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632742": { "compartment": "compartment_70616", "id": "reaction_10632742", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10664426": { "compartment": "compartment_5460", "id": "reaction_10664426", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663602", "species_9012592" ], "products": [ "species_10664424", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307", "WBGene00011307", "WBGene00011307" ] }, "reaction_10632740": { "compartment": "compartment_5460", "id": "reaction_10632740", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10632737", "catalyst" ] ], "additional_components": [ "species_947539", "Q9XTQ8", "WBGene00010397" ] }, "reaction_10663887": { "compartment": "compartment_5460", "id": "reaction_10663887", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10664430": { "compartment": "compartment_5460", "id": "reaction_10664430", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664424", "species_10639549" ], "products": [ "species_10664428" ], "modifiers": [], "additional_components": [ "WBGene00011307", "WBGene00007099", "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307" ] }, "reaction_10632782": { "compartment": "compartment_70101", "id": "reaction_10632782", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632777": { "compartment": "compartment_70616", "id": "reaction_10632777", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10632765", "species_113521" ], "products": [ "species_10632767", "species_1614538", "species_113529" ], "modifiers": [ [ "species_10632774", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "species_216667", "O17636", "WBGene00007886" ] }, "reaction_10632753": { "compartment": "compartment_70101", "id": "reaction_10632753", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10663605": { "compartment": "compartment_5460", "id": "reaction_10663605", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10656962": { "compartment": "compartment_70101", "id": "reaction_10656962", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10656959", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10663885": { "compartment": "compartment_5460", "id": "reaction_10663885", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10657228": { "compartment": "compartment_12045", "id": "reaction_10657228", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10657225", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398", "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399" ] }, "reaction_10623933": { "compartment": "compartment_70101", "id": "reaction_10623933", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10623928", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10648592": { "compartment": "compartment_161320", "id": "reaction_10648592", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10648589", "catalyst" ] ], "additional_components": [ "species_6785219", "species_390435", "WBGene00004092" ] }, "reaction_10623940": { "compartment": "compartment_70101", "id": "reaction_10623940", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_29768", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_548819" ], "modifiers": [ [ "species_10623937", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10602893": { "compartment": "compartment_70101", "id": "reaction_10602893", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10602885", "catalyst" ], [ "species_10602891", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10611701": { "compartment": "compartment_70101", "id": "reaction_10611701", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10611698", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "O44560", "WBGene00020343", "A0A4V0ING4", "WBGene00016716", "V6CLI5", "WBGene00022037", "O16775", "WBGene00019920", "Q21872", "WBGene00011173" ] }, "reaction_10602965": { "compartment": "compartment_70101", "id": "reaction_10602965", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10602962", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10647332": { "compartment": "compartment_12045", "id": "reaction_10647332", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10647329", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517", "Q21905", "WBGene00011205" ] }, "reaction_10623876": { "compartment": "compartment_70101", "id": "reaction_10623876", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10623920": { "compartment": "compartment_70101", "id": "reaction_10623920", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10623917", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20904", "WBGene00001245", "Q20300", "WBGene00001243", "Q03574", "WBGene00001242", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241" ] }, "reaction_10611571": { "compartment": "compartment_70101", "id": "reaction_10611571", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602921", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10623923": { "compartment": "compartment_70101", "id": "reaction_10623923", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10610418", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10606634": { "compartment": "compartment_70101", "id": "reaction_10606634", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602960" ], "products": [ "species_10602962" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10648602": { "compartment": "compartment_12045", "id": "reaction_10648602", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10648599", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10602902": { "compartment": "compartment_70101", "id": "reaction_10602902", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10664094": { "compartment": "compartment_70101", "id": "reaction_10664094", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9023653" ], "products": [ "species_9023651", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664092": { "compartment": "compartment_70101", "id": "reaction_10664092", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10662619": { "compartment": "compartment_17947", "id": "reaction_10662619", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662607" ], "products": [ "species_10662616", "species_10628859" ], "modifiers": [ [ "species_10662607", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10660992": { "compartment": "compartment_70101", "id": "reaction_10660992", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660981", "species_10660979" ], "products": [ "species_10612207", "species_10660989", "species_10660972" ], "modifiers": [ [ "species_10660981", "catalyst" ] ], "additional_components": [ "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10660994": { "compartment": "compartment_70101", "id": "reaction_10660994", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660979", "species_10660972", "species_10660974" ], "products": [ "species_10660981" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10662609": { "compartment": "compartment_17947", "id": "reaction_10662609", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662605", "species_10662601" ], "products": [ "species_10662607" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10643471": { "compartment": "compartment_12045", "id": "reaction_10643471", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10643464" ], "products": [ "species_10643468" ], "modifiers": [ [ "species_10643464", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667" ] }, "reaction_10645821": { "compartment": "compartment_261122", "id": "reaction_10645821", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645817" ], "products": [ "species_10645819" ], "modifiers": [], "additional_components": [ "WBGene00004210", "WBGene00004210" ] }, "reaction_10644533": { "compartment": "compartment_876", "id": "reaction_10644533", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10644526", "catalyst" ], [ "species_10644531", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645932": { "compartment": "compartment_7660", "id": "reaction_10645932", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645929", "species_10597874" ], "products": [ "species_10645923" ], "modifiers": [ [ "species_10645929", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320" ] }, "reaction_10644620": { "compartment": "compartment_70101", "id": "reaction_10644620", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627451", "species_10621559" ], "products": [ "species_10644618" ], "modifiers": [], "additional_components": [ "WBGene00007009", "WBGene00003830", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10644632": { "compartment": "compartment_5263232", "id": "reaction_10644632", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10644628" ], "products": [ "species_10644622", "species_10644630" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10644522": { "compartment": "compartment_18730", "id": "reaction_10644522", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644487", "species_10644518" ], "products": [ "species_10644520" ], "modifiers": [], "additional_components": [ "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645925": { "compartment": "compartment_7660", "id": "reaction_10645925", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645923" ], "products": [ "species_10645921", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10608347": { "compartment": "compartment_70101", "id": "reaction_10608347", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176667" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10629186": { "compartment": "compartment_70101", "id": "reaction_10629186", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10629183", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10608127": { "compartment": "compartment_70101", "id": "reaction_10608127", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10608120" ], "products": [ "species_10608124", "species_174390" ], "modifiers": [ [ "species_10608120", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10608162": { "compartment": "compartment_70101", "id": "reaction_10608162", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10608159", "catalyst" ] ], "additional_components": [ "P27604", "WBGene00019322", "species_29360" ] }, "reaction_10662568": { "compartment": "compartment_17963", "id": "reaction_10662568", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10662565", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "Q5ZEQ3", "WBGene00012390", "species_109496" ] }, "reaction_10606293": { "compartment": "compartment_70101", "id": "reaction_10606293", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158858" ], "products": [ "species_158850", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608369": { "compartment": "compartment_70101", "id": "reaction_10608369", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176575" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608104": { "compartment": "compartment_12045", "id": "reaction_10608104", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10608101", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10608191": { "compartment": "compartment_70101", "id": "reaction_10608191", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_175973" ], "products": [ "species_71285", "species_175979" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10661289": { "compartment": "compartment_876", "id": "reaction_10661289", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247892", "species_109276" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10598417": { "compartment": "compartment_70101", "id": "reaction_10598417", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10598414", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10606403": { "compartment": "compartment_5460", "id": "reaction_10606403", "reactome": "R-CEL-159574", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159557", "species_159549" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10608094": { "compartment": "compartment_70101", "id": "reaction_10608094", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_29404" ], "products": [ "species_29370", "species_174393", "species_29372" ], "modifiers": [ [ "species_10608091", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10608137": { "compartment": "compartment_70101", "id": "reaction_10608137", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174370", "species_113592" ], "products": [ "species_158471", "species_29370" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10608340": { "compartment": "compartment_70101", "id": "reaction_10608340", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608374": { "compartment": "compartment_70101", "id": "reaction_10608374", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10608371", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606330": { "compartment": "compartment_70101", "id": "reaction_10606330", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10624752": { "compartment": "compartment_20699", "id": "reaction_10624752", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10624749", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10619928": { "compartment": "compartment_876", "id": "reaction_10619928", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10619925", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10654763": { "compartment": "compartment_70101", "id": "reaction_10654763", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10608355": { "compartment": "compartment_70101", "id": "reaction_10608355", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10608352", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10629176": { "compartment": "compartment_70101", "id": "reaction_10629176", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10608366": { "compartment": "compartment_70101", "id": "reaction_10608366", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_5695950" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10608363", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606401": { "compartment": "compartment_5460", "id": "reaction_10606401", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10639385": { "compartment": "compartment_5460", "id": "reaction_10639385", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3301954", "species_1655887" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10639382", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10608140": { "compartment": "compartment_70101", "id": "reaction_10608140", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174375", "species_113592" ], "products": [ "species_174370", "species_111294" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10629196": { "compartment": "compartment_70101", "id": "reaction_10629196", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10629193", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10649482": { "compartment": "compartment_70101", "id": "reaction_10649482", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_5696224", "species_29356", "species_111745" ], "modifiers": [ [ "species_10608209", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10608345": { "compartment": "compartment_70101", "id": "reaction_10608345", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176619" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10607919": { "compartment": "compartment_70101", "id": "reaction_10607919", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_158601" ], "modifiers": [ [ "species_10607916", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10608150": { "compartment": "compartment_70101", "id": "reaction_10608150", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10608147", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q21549", "WBGene00010941", "species_109496" ] }, "reaction_10605958": { "compartment": "compartment_70101", "id": "reaction_10605958", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158469" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606295": { "compartment": "compartment_70101", "id": "reaction_10606295", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158847" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608357": { "compartment": "compartment_70101", "id": "reaction_10608357", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608343": { "compartment": "compartment_70101", "id": "reaction_10608343", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_193103" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608256": { "compartment": "compartment_70101", "id": "reaction_10608256", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10608253", "catalyst" ] ], "additional_components": [ "species_76396", "species_3301954", "CHEBI:30614", "CHEBI:34479", "species_9753685", "species_3301969", "O45352", "WBGene00001792", "O45010", "WBGene00021127", "P34345", "WBGene00016204", "Q09596", "WBGene00001753", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337", "Q18938", "WBGene00001790", "P10299", "WBGene00001749" ] }, "reaction_10648957": { "compartment": "compartment_17957", "id": "reaction_10648957", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10648954", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10606424": { "compartment": "compartment_20699", "id": "reaction_10606424", "reactome": "R-CEL-159728", "name": "Furin cleaves pro-prothrombin to prothrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606405" ], "products": [ "species_10606409", "species_10606407" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "WBGene00008879", "WBGene00008879", "WBGene00008879", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10650363": { "compartment": "compartment_12045", "id": "reaction_10650363", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10650360", "catalyst" ] ], "additional_components": [ "species_216667", "P91402", "WBGene00019710" ] }, "reaction_10643368": { "compartment": "compartment_70101", "id": "reaction_10643368", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643348", "species_71284" ], "products": [ "species_353106", "species_10643335" ], "modifiers": [ [ "species_10643365", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "Q09454", "WBGene00007488", "P49958", "WBGene00007576", "Q21102", "WBGene00010484" ] }, "reaction_10606692": { "compartment": "compartment_20699", "id": "reaction_10606692", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606676" ], "products": [ "species_10606684", "species_10606690" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10643346": { "compartment": "compartment_70101", "id": "reaction_10643346", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643335", "species_71284" ], "products": [ "species_10643338", "species_71285" ], "modifiers": [ [ "species_10643343", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10650384": { "compartment": "compartment_70101", "id": "reaction_10650384", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_29370", "species_6788858" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10606430": { "compartment": "compartment_13959", "id": "reaction_10606430", "reactome": "R-CEL-159843", "name": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606428" ], "products": [ "species_10606405" ], "modifiers": [], "additional_components": [ "WBGene00008879", "WBGene00008879" ] }, "reaction_10613073": { "compartment": "compartment_70101", "id": "reaction_10613073", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_204628" ], "products": [ "species_29360", "species_204635", "species_10613063" ], "modifiers": [ [ "species_10613070", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10606678": { "compartment": "compartment_13959", "id": "reaction_10606678", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670" ], "products": [ "species_10606676" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10650386": { "compartment": "compartment_70101", "id": "reaction_10650386", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788868", "species_113592" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:24103", "CHEBI:87176", "CHEBI:87177", "CHEBI:87178", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10643332": { "compartment": "compartment_70101", "id": "reaction_10643332", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643324", "species_113592", "species_31633" ], "products": [ "species_10605934", "species_111294", "species_76577" ], "modifiers": [ [ "species_10643329", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10613101": { "compartment": "compartment_70101", "id": "reaction_10613101", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10613091" ], "modifiers": [ [ "species_10613098", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "species_113531", "Q17949", "WBGene00007555" ] }, "reaction_10648553": { "compartment": "compartment_7660", "id": "reaction_10648553", "reactome": "R-CEL-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10648537" ], "products": [ "species_10648551" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "Q95PZ4", "WBGene00013441", "P53016", "WBGene00004340", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "P34429", "WBGene00018409", "Q93456", "WBGene00008665", "Q19366", "WBGene00008722", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648672": { "compartment": "compartment_7660", "id": "reaction_10648672", "reactome": "R-CEL-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648669" ], "products": [ "species_10648537" ], "modifiers": [ [ "species_10648669", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320" ] }, "reaction_10663517": { "compartment": "compartment_876", "id": "reaction_10663517", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_10636623" ], "products": [ "species_10663515" ], "modifiers": [], "additional_components": [ "WBGene00004854", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "G5EFX6", "WBGene00004854" ] }, "reaction_10657351": { "compartment": "compartment_20699", "id": "reaction_10657351", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10657483": { "compartment": "compartment_12045", "id": "reaction_10657483", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657445", "species_113592" ], "products": [ "species_29370", "species_10657463", "species_10656090", "species_10657432" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10657481", "catalyst" ] ], "additional_components": [ "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "V6CJ04", "WBGene00016611", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10657547": { "compartment": "compartment_12045", "id": "reaction_10657547", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657543", "species_10657475" ], "products": [ "species_10657545" ], "modifiers": [], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656574": { "compartment": "compartment_20699", "id": "reaction_10656574", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656558", "species_10655931", "species_10656284", "species_10656560", "species_10656570" ], "products": [ "species_10656572" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "WBGene00018853", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "P90904", "WBGene00010500", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195" ] }, "reaction_10656616": { "compartment": "compartment_12045", "id": "reaction_10656616", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656614" ], "products": [ "species_10656607" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657436": { "compartment": "compartment_20699", "id": "reaction_10657436", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657419", "species_10657417", "species_10657432" ], "products": [ "species_10657434" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10656702": { "compartment": "compartment_12045", "id": "reaction_10656702", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656700" ], "products": [ "species_10649098", "species_10656652", "species_10656614", "species_10655913", "species_10656698" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q9N598", "WBGene00022460", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "Q19642", "WBGene00017643", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P90841", "WBGene00008990", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "species_29420", "Q9UAQ6", "WBGene00004266", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195" ] }, "reaction_10657447": { "compartment": "compartment_20699", "id": "reaction_10657447", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657434", "species_10657443" ], "products": [ "species_10657445", "species_10657441" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9NDC9", "WBGene00003047", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "WBGene00003047" ] }, "reaction_10656554": { "compartment": "compartment_20699", "id": "reaction_10656554", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656258", "species_10655846" ], "products": [ "species_10656552" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438" ] }, "reaction_10656610": { "compartment": "compartment_12045", "id": "reaction_10656610", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656607" ], "products": [ "species_10649229", "species_10656598", "species_10656603", "species_10649213", "species_10612598", "species_10656593", "species_29372" ], "modifiers": [ [ "species_10656607", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00020425", "WBGene00022460", "Q94392", "WBGene00003818", "WBGene00018853", "WBGene00018239", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657550": { "compartment": "compartment_12045", "id": "reaction_10657550", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10657545" ], "products": [ "species_10657481", "species_29420" ], "modifiers": [ [ "species_10657545", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656618": { "compartment": "compartment_432051", "id": "reaction_10656618", "reactome": "R-CEL-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628218", "species_10656588" ], "products": [ "species_10656612" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "Q9UAQ6", "WBGene00004266", "O17528", "WBGene00004766", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "Q20546", "WBGene00009829", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "O44738", "WBGene00019003", "H2L2E8", "WBGene00006528", "O17528", "WBGene00004766", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P48583", "WBGene00001331", "P12456", "WBGene00003171", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "P34690", "WBGene00006529", "Q18864", "WBGene00004788", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q94241", "WBGene00018853" ] }, "reaction_10647110": { "compartment": "compartment_876", "id": "reaction_10647110", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647066" ], "products": [ "species_29370", "species_10647091" ], "modifiers": [ [ "species_10647066", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647108", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647102": { "compartment": "compartment_876", "id": "reaction_10647102", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647091" ], "products": [ "species_29370", "species_10647093" ], "modifiers": [ [ "species_10647091", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647096", "inhibitor" ], [ "species_10647100", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", 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"pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10665556": { "compartment": "compartment_876", "id": "reaction_10665556", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10647066" ], "products": [ "species_10647098" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647155": { "compartment": "compartment_74700", "id": "reaction_10647155", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647145", "species_10647147", "species_10618746", "species_10647064" ], "products": [ "species_10647149" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10665558": { "compartment": "compartment_876", "id": "reaction_10665558", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647091", "species_9657570" ], "products": [ "species_10647100" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647113": { "compartment": "compartment_876", "id": "reaction_10647113", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647093" ], "products": [ "species_10647054", "species_10647068", "species_10618752", "species_10647089" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186" ] }, "reaction_10665560": { "compartment": "compartment_876", "id": "reaction_10665560", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657574", "species_10647091" ], "products": [ "species_10647096" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647185": { "compartment": "compartment_20699", "id": "reaction_10647185", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647178" ], "products": [ "species_10647182", "species_29370" ], "modifiers": [ [ "species_10647178", "catalyst" ] ], "additional_components": [ "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10647077": { "compartment": "compartment_876", "id": "reaction_10647077", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647054", "species_10647030", "species_10618746", "species_10647064" ], "products": [ "species_10647066" ], "modifiers": [ [ "species_10647075", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647180": { "compartment": "compartment_20699", "id": "reaction_10647180", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10647089", "species_10647176" ], "products": [ "species_10647178" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10665564": { "compartment": "compartment_876", "id": "reaction_10665564", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10647093" ], "products": [ "species_10665562" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9229", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647153": { "compartment": "compartment_74700", "id": "reaction_10647153", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647149" ], "products": [ "species_29370", "species_10647151" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10630903": { "compartment": "compartment_70616", "id": "reaction_10630903", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10630925": { "compartment": "compartment_12045", "id": "reaction_10630925", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10630895": { "compartment": "compartment_12045", "id": "reaction_10630895", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498740", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10631927": { "compartment": "compartment_984", "id": "reaction_10631927", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602402", "species_109276" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10630962": { "compartment": "compartment_70616", "id": "reaction_10630962", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10657697": { "compartment": "compartment_70101", "id": "reaction_10657697", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647007", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947", "Q9XWK4", "WBGene00013202" ] }, "reaction_10657694": { "compartment": "compartment_70101", "id": "reaction_10657694", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647009", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10642565": { "compartment": "compartment_13231", "id": "reaction_10642565", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10641096", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10642747": { "compartment": "compartment_7660", "id": "reaction_10642747", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642729", "species_29358" ], "products": [ "species_113582", "species_10642745" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q21443", "WBGene00003052", "Q21443", "WBGene00003052", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10642573": { "compartment": "compartment_13231", "id": "reaction_10642573", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29496", "species_10642567", "species_5221124" ], "products": [ "species_10642571" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10642190": { "compartment": "compartment_7660", "id": "reaction_10642190", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641096" ], "products": [ "species_113582", "species_10641090" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10641115": { "compartment": "compartment_13231", "id": "reaction_10641115", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10641090" ], "products": [ "species_113550", "species_10641096" ], "modifiers": [ [ "species_10641112", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q9XXN3", "WBGene00011828", "Q20432", "WBGene00018474" ] }, "reaction_10638146": { "compartment": "compartment_70101", "id": "reaction_10638146", "reactome": "R-CEL-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602774" ], "products": [ "species_10638130", "species_29370" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10651289": { "compartment": "compartment_70101", "id": "reaction_10651289", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651285", "species_10617017" ], "products": [ "species_10651287" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488" ] }, "reaction_10651323": { "compartment": "compartment_876", "id": "reaction_10651323", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651319", "species_10612288" ], "products": [ "species_10651321" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006", "WBGene00010664", "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q9XUT0", "WBGene00010664", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006" ] }, "reaction_10617553": { "compartment": "compartment_70101", "id": "reaction_10617553", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617549", "species_10617493" ], "products": [ "species_10617551" ], "modifiers": [], "additional_components": [ "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q21049", "WBGene00006364", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "Q94071", "WBGene00011904", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748" ] }, "reaction_10651237": { "compartment": "compartment_876", "id": "reaction_10651237", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651191", "species_10651233" ], "products": [ "species_10651235" ], "modifiers": [], "additional_components": [ "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10651327": { "compartment": "compartment_876", "id": "reaction_10651327", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651287", "species_10651235" ], "products": [ "species_10651325" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "I2HAJ6", "WBGene00007799", "G5EEG8", "WBGene00001488", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10657531": { "compartment": "compartment_876", "id": "reaction_10657531", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10657527" ], "products": [ "species_10657529" ], "modifiers": [], "additional_components": [ "WBGene00001006", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5ECY0", "WBGene00001006" ] }, "reaction_10644074": { "compartment": "compartment_5460", "id": "reaction_10644074", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_10644070", "species_10644061" ], "products": [ "species_10644072" ], "modifiers": [], "additional_components": [ "Q95QC2", "WBGene00019838", "O44568", "WBGene00020993", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "O44568", "WBGene00020993", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644103": { "compartment": "compartment_5460", "id": "reaction_10644103", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644078", "species_10644092" ], "products": [ "species_10644101" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "WBGene00020625", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644080": { "compartment": "compartment_5460", "id": "reaction_10644080", "reactome": "R-CEL-5419271", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644072" ], "products": [ "species_10644078", "species_10644070", "species_113548", "species_113525", "species_5419287" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", 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that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q95Y73", "WBGene00022491", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644059": { "compartment": "compartment_5460", "id": "reaction_10644059", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644055", "species_10644048" ], "products": [ "species_10644057" ], "modifiers": [], "additional_components": [ "Q9XV52", "WBGene00009246", "species_29438", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "Q9XV52", "WBGene00009246", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10630939": { "compartment": "compartment_12045", "id": "reaction_10630939", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10659187": { "compartment": "compartment_12045", "id": "reaction_10659187", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10659184", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10630965": { "compartment": "compartment_12045", "id": "reaction_10630965", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631930": { "compartment": "compartment_984", "id": "reaction_10631930", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10663355": { "compartment": "compartment_5460", "id": "reaction_10663355", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663347" ], "products": [], "modifiers": [ [ "species_10663352", "catalyst" ] ], "additional_components": [ "Q9BKS0", "WBGene00022336", "Q8I7J4", "WBGene00000762", "Q9XWJ5", "WBGene00013094", "P46561", "WBGene00000229", "Q8I4K2", "WBGene00009334", "WBGene00011679" ] }, "reaction_10625828": { "compartment": "compartment_876", "id": "reaction_10625828", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "species_71185", "CHEBI:36144", "species_71185", "CHEBI:36144", "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10629240": { "compartment": "compartment_70101", "id": "reaction_10629240", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_1250243" ], "products": [ "species_10601705" ], "modifiers": [], "additional_components": [ "WBGene00020917", "WBGene00020917" ] }, "reaction_10629211": { "compartment": "compartment_70101", "id": "reaction_10629211", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629198" ], "products": [ "species_29370", "species_10629208" ], "modifiers": [ [ "species_10622456", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004758" ] }, "reaction_10634116": { "compartment": "compartment_70101", "id": "reaction_10634116", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634100" ], "products": [ "species_10634109" ], "modifiers": [ [ "species_10634114", "inhibitor" ] ], "additional_components": [ "P41990", "WBGene00000168", "P41990", "WBGene00000168", "WBGene00004766" ] }, "reaction_10664120": { "compartment": "compartment_7660", "id": "reaction_10664120", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10664115" ], "products": [ "species_113582", "species_10664115" ], "modifiers": [ [ "species_10664117", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10629322": { "compartment": "compartment_70101", "id": "reaction_10629322", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629255" ], "products": [ "species_10629265" ], "modifiers": [ [ "species_10629319", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "O02100", "WBGene00001985", "O45876", "WBGene00000147", "Q9U357", "WBGene00003975", "Q23316", "WBGene00000148", "Q01608", "WBGene00004958", "P52166", "WBGene00004769" ] }, "reaction_10629346": { "compartment": "compartment_70101", "id": "reaction_10629346", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629341", "species_10597908" ], "products": [ "species_10629343" ], "modifiers": [ [ "species_10629341", "catalyst" ] ], "additional_components": [ "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629372": { "compartment": "compartment_70101", "id": "reaction_10629372", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10629265" ], "products": [ "species_10629364" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629357": { "compartment": "compartment_70101", "id": "reaction_10629357", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10629265" ], "products": [ "species_10629355" ], "modifiers": [], "additional_components": [ "WBGene00017131", "P24348", "WBGene00002299", "Q95QN9", "WBGene00017131", "P24348", "WBGene00002299" ] }, "reaction_10629396": { "compartment": "compartment_70101", "id": "reaction_10629396", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629384" ], "products": [ "species_10629394" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10629370": { "compartment": "compartment_70101", "id": "reaction_10629370", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629364" ], "products": [ "species_10629368" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629398": { "compartment": "compartment_70101", "id": "reaction_10629398", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10629382" ], "products": [ "species_10629384" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10664835": { "compartment": "compartment_876", "id": "reaction_10664835", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10615184" ], "products": [ "species_10629334" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00005077", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10629348": { "compartment": "compartment_876", "id": "reaction_10629348", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627496", "species_10629339" ], "products": [ "species_10629341" ], "modifiers": [], "additional_components": [ "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629410": { "compartment": "compartment_70101", "id": "reaction_10629410", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629408" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10634331": { "compartment": "compartment_70101", "id": "reaction_10634331", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634324", "species_10597908" ], "products": [ "species_10634328" ], "modifiers": [ [ "species_10634324", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10629336": { "compartment": "compartment_70101", "id": "reaction_10629336", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629332" ], "modifiers": [ [ "species_10629334", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10634326": { "compartment": "compartment_70101", "id": "reaction_10634326", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627458", "species_10629259" ], "products": [ "species_10634324" ], "modifiers": [], "additional_components": [ "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10605846": { "compartment": "compartment_70101", "id": "reaction_10605846", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840" ], "products": [ "species_10605844" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10605848": { "compartment": "compartment_70101", "id": "reaction_10605848", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840", "species_10605825", "species_10605830" ], "products": [ "species_10605842" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q21776", "WBGene00000275", "O02053", "WBGene00004721", "WBGene00013209", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "O02053", "WBGene00004721", "Q09373", "WBGene00001511" ] }, "reaction_10607997": { "compartment": "compartment_7660", "id": "reaction_10607997", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607992" ], "products": [ "species_113582", "species_10607994" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10605577": { "compartment": "compartment_70101", "id": "reaction_10605577", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10605570" ], "products": [ "species_10605572" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619745": { "compartment": "compartment_876", "id": "reaction_10619745", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619741", "species_114519" ], "products": [ "species_10619743" ], "modifiers": [], "additional_components": [ "P34586", "WBGene00006614", "G5EF09", "WBGene00004976", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10619520": { "compartment": "compartment_70101", "id": "reaction_10619520", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610919", "species_114519" ], "products": [ "species_10619518" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10649353": { "compartment": "compartment_876", "id": "reaction_10649353", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694509", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10649350", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10605575": { "compartment": "compartment_114521", "id": "reaction_10605575", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10605572", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619788": { "compartment": "compartment_70101", "id": "reaction_10619788", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10619785", "catalyst" ] ], "additional_components": [ "H2KZC9", "WBGene00006483", "Q03603", "WBGene00000960", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958", "Q10024", "WBGene00019428" ] }, "reaction_10619647": { "compartment": "compartment_876", "id": "reaction_10619647", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10619644", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10650309": { "compartment": "compartment_70101", "id": "reaction_10650309", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788291", "species_29356" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10650306", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_109496" ] }, "reaction_10602217": { "compartment": "compartment_70101", "id": "reaction_10602217", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q23588", "WBGene00022817" ] }, "reaction_10601699": { "compartment": "compartment_70101", "id": "reaction_10601699", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10601696", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10662627": { "compartment": "compartment_70101", "id": "reaction_10662627", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10662624", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "WBGene00008948" ] }, "reaction_10601683": { "compartment": "compartment_70101", "id": "reaction_10601683", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10601680", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_216667", "Q20628", "WBGene00000392" ] }, "reaction_10601663": { "compartment": "compartment_70101", "id": "reaction_10601663", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10601660", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604531": { "compartment": "compartment_70101", "id": "reaction_10604531", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10604528", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604921": { "compartment": "compartment_70101", "id": "reaction_10604921", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604918", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10661713": { "compartment": "compartment_70101", "id": "reaction_10661713", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10604862" ], "products": [ "species_10604864" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389" ] }, "reaction_10621546": { "compartment": "compartment_70101", "id": "reaction_10621546", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10621538" ], "products": [ "species_113582", "species_10621543" ], "modifiers": [ [ "species_10621538", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604963": { "compartment": "compartment_876", "id": "reaction_10604963", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604936" ], "products": [ "species_29370", "species_10604960" ], "modifiers": [ [ "species_10604954", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604900": { "compartment": "compartment_876", "id": "reaction_10604900", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10604895", "catalyst" ], [ "species_10604898", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604956": { "compartment": "compartment_70101", "id": "reaction_10604956", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604898" ], "products": [ "species_10604938" ], "modifiers": [ [ "species_10604954", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "Q09639", "WBGene00001709", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604868": { "compartment": "compartment_70101", "id": "reaction_10604868", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604864" ], "products": [ "species_10604866", "species_10604860" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10604923": { "compartment": "compartment_70101", "id": "reaction_10604923", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604918" ], "products": [ "species_10604918" ], "modifiers": [ [ "species_10604898", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10651257": { "compartment": "compartment_70101", "id": "reaction_10651257", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10651245" ], "products": [ "species_29370", "species_10651255" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655489": { "compartment": "compartment_70101", "id": "reaction_10655489", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655483" ], "products": [ "species_10655487" ], "modifiers": [], "additional_components": [ "WBGene00009647", "WBGene00009647" ] }, "reaction_10645807": { "compartment": "compartment_70101", "id": "reaction_10645807", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645791", "species_10645799" ], "products": [ "species_10645805" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598469": { "compartment": "compartment_70101", "id": "reaction_10598469", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10598466", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10599754": { "compartment": "compartment_70101", "id": "reaction_10599754", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10599751", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10651416": { "compartment": "compartment_7660", "id": "reaction_10651416", "reactome": "R-CEL-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651410", "species_29358" ], "products": [ "species_113582", "species_10651414" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003150", "WBGene00003150", "WBGene00000227" ] }, "reaction_10639605": { "compartment": "compartment_70101", "id": "reaction_10639605", "reactome": "R-CEL-3341277", "name": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10636065", "catalyst" ] ], "additional_components": [ "Q93204", "WBGene00007516" ] }, "reaction_10655691": { "compartment": "compartment_70101", "id": "reaction_10655691", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655683" ], "products": [ "species_10655685" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10645811": { "compartment": "compartment_70101", "id": "reaction_10645811", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617093", "species_10645799" ], "products": [ "species_10645809" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "WBGene00022279", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q9N4D6", "WBGene00022279", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10655536": { "compartment": "compartment_876", "id": "reaction_10655536", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655527", "species_10655532" ], "products": [ "species_10655534" ], "modifiers": [], "additional_components": [ "WBGene00019778", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10662505": { "compartment": "compartment_7660", "id": "reaction_10662505", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662497" ], "products": [ "species_10662503" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10662495": { "compartment": "compartment_7660", "id": "reaction_10662495", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491" ], "products": [ "species_10662493" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10655485": { "compartment": "compartment_7660", "id": "reaction_10655485", "reactome": "R-CEL-6800490", "name": "ATM phosphorylates PIDD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10655480" ], "products": [ "species_113582", "species_10655483" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00009647", "WBGene00009647", "WBGene00000227" ] }, "reaction_10598826": { "compartment": "compartment_5460", "id": "reaction_10598826", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113522" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10598823", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q93650", "WBGene00009271", "Q19013", "WBGene00008435" ] }, "reaction_10660349": { "compartment": "compartment_7660", "id": "reaction_10660349", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625955", "species_10660342" ], "products": [ "species_10660347" ], "modifiers": [], "additional_components": [ "WBGene00022448", "Q9BL73", "WBGene00004088", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10651355": { "compartment": "compartment_7660", "id": "reaction_10651355", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651335", "species_10651264" ], "products": [ "species_10651337" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655689": { "compartment": "compartment_70101", "id": "reaction_10655689", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655677", "species_10655685" ], "products": [ "species_10655687" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "P41932", "WBGene00003920", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10645794": { "compartment": "compartment_70101", "id": "reaction_10645794", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10639622" ], "products": [ "species_10645791", "species_29356" ], "modifiers": [ [ "species_10639622", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598605": { "compartment": "compartment_70101", "id": "reaction_10598605", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10598600", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10651266": { "compartment": "compartment_7660", "id": "reaction_10651266", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651262" ], "products": [ "species_10651264" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10660345": { "compartment": "compartment_7660", "id": "reaction_10660345", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10660331" ], "products": [ "species_113582", "species_10660342" ], "modifiers": [ [ "species_10622470", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10651272": { "compartment": "compartment_7660", "id": "reaction_10651272", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651268" ], "products": [ "species_10651270" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10662501": { "compartment": "compartment_7660", "id": "reaction_10662501", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491", "species_10662497" ], "products": [ "species_10662499" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10639631": { "compartment": "compartment_70101", "id": "reaction_10639631", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10601707" ], "products": [ "species_29356", "species_10601705" ], "modifiers": [ [ "species_10639628", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10651247": { "compartment": "compartment_70101", "id": "reaction_10651247", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637490" ], "products": [ "species_29370", "species_10651245" ], "modifiers": [ [ "species_10611000", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583" ] }, "reaction_10655545": { "compartment": "compartment_70101", "id": "reaction_10655545", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655534", "species_10655541" ], "products": [ "species_10655543" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10617109": { "compartment": "compartment_70101", "id": "reaction_10617109", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106", "species_29372" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10651353": { "compartment": "compartment_7660", "id": "reaction_10651353", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10651337" ], "products": [ "species_113582", "species_10651350" ], "modifiers": [ [ "species_10651337", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655741": { "compartment": "compartment_7660", "id": "reaction_10655741", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605168", "species_10655737" ], "products": [ "species_10655739" ], "modifiers": [], "additional_components": [ "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P41848", "WBGene00001974", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849" ] }, "reaction_10614736": { "compartment": "compartment_984", "id": "reaction_10614736", "reactome": "R-CEL-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10614732" ], "products": [ "species_10614734" ], "modifiers": [], "additional_components": [ "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "species_265479", "Q19127", "WBGene00003561", "P34389", "WBGene00003562" ] }, "reaction_10661657": { "compartment": "compartment_70101", "id": "reaction_10661657", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661653" ], "products": [ "species_10661655" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661663": { "compartment": "compartment_70101", "id": "reaction_10661663", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559", "species_10661617" ], "products": [ "species_10661653" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10617891": { "compartment": "compartment_984", "id": "reaction_10617891", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10617885": { "compartment": "compartment_984", "id": "reaction_10617885", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616519" ], "products": [ "species_10616523" ], "modifiers": [ [ "species_10617883", "catalyst" ], [ "species_10617881", "inhibitor" ] ], "additional_components": [ "species_374935", "species_209794", "WBGene00008890", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=483", "LigandDisplayForward?ligandId=485", "LigandDisplayForward?ligandId=124", "LigandDisplayForward?ligandId=480", "LigandDisplayForward?ligandId=3469", "LigandDisplayForward?ligandId=481", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=7302", "LigandDisplayForward?ligandId=503", "LigandDisplayForward?ligandId=7170" ] }, "reaction_10656795": { "compartment": "compartment_70101", "id": "reaction_10656795", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610899", "species_29356" ], "products": [ "species_29372", "species_10617854" ], "modifiers": [ [ "species_10656790", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10636518": { "compartment": "compartment_70101", "id": "reaction_10636518", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636515", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "species_179838", "Q10656", "WBGene00001184", "Q45FX5", "WBGene00006887", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "O18008", "WBGene00021745" ] }, "reaction_10633249": { "compartment": "compartment_876", "id": "reaction_10633249", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633061": { "compartment": "compartment_876", "id": "reaction_10633061", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633058", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10658313": { "compartment": "compartment_70101", "id": "reaction_10658313", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610622", "species_113592" ], "products": [ "species_29370", "species_10658301" ], "modifiers": [ [ "species_10658310", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [ "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10642713": { "compartment": "compartment_70101", "id": "reaction_10642713", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612004", "species_113592" ], "products": [ "species_29370", "species_10610661" ], "modifiers": [ [ "species_10612004", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10661437": { "compartment": "compartment_7660", "id": "reaction_10661437", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661433", "species_10639314" ], "products": [ "species_10661435" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10635829": { "compartment": "compartment_70101", "id": "reaction_10635829", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613633", "species_10610677" ], "products": [ "species_10635827" ], "modifiers": [], "additional_components": [ "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610705": { "compartment": "compartment_70101", "id": "reaction_10610705", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610692", "species_113592" ], "products": [ "species_10610672", "species_29370" ], "modifiers": [ [ "species_10610692", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10635835": { "compartment": "compartment_70101", "id": "reaction_10635835", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635831" ], "products": [ "species_10613633", "species_10635833", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10635837": { "compartment": "compartment_70101", "id": "reaction_10635837", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635827", "species_10597908" ], "products": [ "species_10635831" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10641384": { "compartment": "compartment_7660", "id": "reaction_10641384", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639298" ], "products": [ "species_10639314" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10610714": { "compartment": "compartment_70101", "id": "reaction_10610714", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610709", "species_113592" ], "products": [ "species_29370", "species_10610699" ], "modifiers": [ [ "species_10610709", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610684": { "compartment": "compartment_70101", "id": "reaction_10610684", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610677" ], "products": [ "species_10610677" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610702": { "compartment": "compartment_70101", "id": "reaction_10610702", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610699" ], "products": [ "species_29370", "species_10610688" ], "modifiers": [ [ "species_10610699", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610711": { "compartment": "compartment_70101", "id": "reaction_10610711", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610661", "species_10610707" ], "products": [ "species_10610709" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00001979", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610695": { "compartment": "compartment_70101", "id": "reaction_10610695", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610688" ], "products": [ "species_29370", "species_10610692" ], "modifiers": [ [ "species_10610688", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10643089": { "compartment": "compartment_7660", "id": "reaction_10643089", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638387", "species_10639287" ], "products": [ "species_10643087" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10610682": { "compartment": "compartment_70101", "id": "reaction_10610682", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610672", "species_113592" ], "products": [ "species_29370", "species_10610677" ], "modifiers": [ [ "species_10610672", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10654727": { "compartment": "compartment_70101", "id": "reaction_10654727", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10654724", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10598546": { "compartment": "compartment_70101", "id": "reaction_10598546", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29360", "species_29372" ], "products": [ "species_70106", "species_73473", "species_29800" ], "modifiers": [ [ "species_10598543", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17331", "WBGene00001686", "P17329", "WBGene00001684", "P17330", "WBGene00001685" ] }, "reaction_10599692": { "compartment": "compartment_70101", "id": "reaction_10599692", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29492", "species_29356" ], "modifiers": [ [ "species_10598654", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_109496" ] }, "reaction_10599874": { "compartment": "compartment_70101", "id": "reaction_10599874", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10598638", "catalyst" ] ], "additional_components": [ "P91427", "WBGene00020185", "species_109496" ] }, "reaction_10649423": { "compartment": "compartment_12045", "id": "reaction_10649423", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10649420", "catalyst" ] ], "additional_components": [ "Q86S40", "WBGene00016810", "species_109496" ] }, "reaction_10598593": { "compartment": "compartment_70101", "id": "reaction_10598593", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10598590", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10598507": { "compartment": "compartment_70101", "id": "reaction_10598507", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10598504", "catalyst" ] ], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599870": { "compartment": "compartment_70101", "id": "reaction_10599870", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10599867", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10662663": { "compartment": "compartment_70101", "id": "reaction_10662663", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10598402", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10599719": { "compartment": "compartment_70101", "id": "reaction_10599719", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10599716", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001", "species_74126", "species_109496" ] }, "reaction_10598391": { "compartment": "compartment_70101", "id": "reaction_10598391", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598388", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295" ] }, "reaction_10598556": { "compartment": "compartment_70101", "id": "reaction_10598556", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10598553", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10607710": { "compartment": "compartment_13231", "id": "reaction_10607710", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607708" ], "products": [ "species_10598486" ], "modifiers": [], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10599566", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10625184": { "compartment": "compartment_5460", "id": "reaction_10625184", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_880046", "species_113526" ], "products": [ "species_113536", "species_29362", "species_113529" ], "modifiers": [ [ "species_10625181", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10625666": { "compartment": "compartment_5460", "id": "reaction_10625666", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10625663", "catalyst" ] ], "additional_components": [ "Q21217", "WBGene00001794", "CHEBI:33739" ] }, "reaction_10641688": { "compartment": "compartment_7660", "id": "reaction_10641688", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_77087" ], "products": [ "species_10641673", "species_77502" ], "modifiers": [ [ "species_10641685", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10642433": { "compartment": "compartment_7660", "id": "reaction_10642433", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642398", "species_77087" ], "products": [ "species_10642431", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00013766" ] }, "reaction_10646433": { "compartment": "compartment_7660", "id": "reaction_10646433", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642265", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10646024": { "compartment": "compartment_7660", "id": "reaction_10646024", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646006", "species_77087" ], "products": [ "species_77502", "species_10646022" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10638598": { "compartment": "compartment_7660", "id": "reaction_10638598", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586" ], "products": [ "species_29478", "species_10638588" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10642756": { "compartment": "compartment_7660", "id": "reaction_10642756", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_77087" ], "products": [ "species_10642749", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ], [ "species_10642358", "inhibitor" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10642562": { "compartment": "compartment_7660", "id": "reaction_10642562", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10642554", "species_77502" ], "modifiers": [ [ "species_10642559", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012298" ] }, "reaction_10641713": { "compartment": "compartment_7660", "id": "reaction_10641713", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10641526", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646014": { "compartment": "compartment_7660", "id": "reaction_10646014", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645998", "species_77087" ], "products": [ "species_10646006", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10641594": { "compartment": "compartment_7660", "id": "reaction_10641594", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10638586", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10640230": { "compartment": "compartment_7660", "id": "reaction_10640230", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640227", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "Q18919", "WBGene00005006", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "Q95Y41", "WBGene00022278" ] }, "reaction_10641550": { "compartment": "compartment_7660", "id": "reaction_10641550", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10639479": { "compartment": "compartment_7660", "id": "reaction_10639479", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639441", "species_113560" ], "products": [ "species_10639476", "species_2485002" ], "modifiers": [ [ "species_10607230", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10646440": { "compartment": "compartment_7660", "id": "reaction_10646440", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10642265" ], "products": [ "species_10646438", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10646427": { "compartment": "compartment_7660", "id": "reaction_10646427", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10646028", "species_113685" ], "products": [ "species_159942", "species_10641602", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10642588": { "compartment": "compartment_7660", "id": "reaction_10642588", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614312", "species_10638588" ], "products": [ "species_10642586" ], "modifiers": [ [ "species_10642554", "inhibitor" ] ], "additional_components": [ "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10641564": { "compartment": "compartment_7660", "id": "reaction_10641564", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641547", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646429": { "compartment": "compartment_7660", "id": "reaction_10646429", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642356", "species_113671", "species_113685" ], "products": [ "species_10638866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10639435": { "compartment": "compartment_7660", "id": "reaction_10639435", "reactome": "R-CEL-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639388", "species_113560" ], "products": [ "species_2485002", "species_10639394" ], "modifiers": [ [ "species_10639432", "catalyst" ] ], "additional_components": [ "WBGene00001914", "WBGene00001914", "A3QMD7", "WBGene00020287", "Q95ZX6", "WBGene00007914", "Q9N3F6", "WBGene00021810", "Q8WQC3", "WBGene00015001" ] }, "reaction_10641627": { "compartment": "compartment_7660", "id": "reaction_10641627", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641602", "species_113671", "species_113685" ], "products": [ "species_10641610", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646425": { "compartment": "compartment_7660", "id": "reaction_10646425", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641673", "species_113685" ], "products": [ "species_10641545", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10641572": { "compartment": "compartment_7660", "id": "reaction_10641572", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638866", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10645990": { "compartment": "compartment_7660", "id": "reaction_10645990", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641526", "species_77087" ], "products": [ "species_10645980", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646415": { "compartment": "compartment_7660", "id": "reaction_10646415", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642749", "species_113685" ], "products": [ "species_10641580", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10645875": { "compartment": "compartment_70101", "id": "reaction_10645875", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10645859" ], "products": [ "species_71285", "species_10645865" ], "modifiers": [ [ "species_10645870", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00001207" ] }, "reaction_10642584": { "compartment": "compartment_7660", "id": "reaction_10642584", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641985", "species_10642554" ], "products": [ "species_10642582" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10645934": { "compartment": "compartment_7660", "id": "reaction_10645934", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586", "species_77087" ], "products": [ "species_10641580", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10641543": { "compartment": "compartment_7660", "id": "reaction_10641543", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641526", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646413": { "compartment": "compartment_7660", "id": "reaction_10646413", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646026": { "compartment": "compartment_7660", "id": "reaction_10646026", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10645998", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10646431": { "compartment": "compartment_7660", "id": "reaction_10646431", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580" ], "products": [ "species_10638586", "species_29478" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10640361": { "compartment": "compartment_7660", "id": "reaction_10640361", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640358", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q20296", "WBGene00018319", "Q8I4I9", "WBGene00009663", "Q9U266", "WBGene00001838" ] }, "reaction_10646411": { "compartment": "compartment_7660", "id": "reaction_10646411", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645980", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10641526", "species_29478" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646435": { "compartment": "compartment_7660", "id": "reaction_10646435", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642363", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10642265" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10644106": { "compartment": "compartment_7660", "id": "reaction_10644106", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_77502", "species_10636181" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10644109": { "compartment": "compartment_7660", "id": "reaction_10644109", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10636181" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10636190", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10641995": { "compartment": "compartment_7660", "id": "reaction_10641995", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10638586", "species_77502" ], "modifiers": [ [ "species_10641992", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10640129": { "compartment": "compartment_7660", "id": "reaction_10640129", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639929", "species_113560" ], "products": [ "species_2485002", "species_10640126" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00000366" ] }, "reaction_10642268": { "compartment": "compartment_7660", "id": "reaction_10642268", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_10642265", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10639915": { "compartment": "compartment_7660", "id": "reaction_10639915", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_113560" ], "products": [ "species_2485002", "species_10639905" ], "modifiers": [ [ "species_10639912", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q21484", "WBGene00044069" ] }, "reaction_10617848": { "compartment": "compartment_17951", "id": "reaction_10617848", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_141343" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10617805": { "compartment": "compartment_17951", "id": "reaction_10617805", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10617802", "catalyst" ] ], "additional_components": [ "Q20992", "WBGene00019060", "species_113596" ] }, "reaction_10617812": { "compartment": "compartment_17951", "id": "reaction_10617812", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617810": { "compartment": "compartment_17951", "id": "reaction_10617810", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617814": { "compartment": "compartment_17951", "id": "reaction_10617814", "reactome": "R-CEL-390224", "name": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389996", "species_193514" ], "products": [ "species_390002", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10617795": { "compartment": "compartment_17951", "id": "reaction_10617795", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10617807": { "compartment": "compartment_17951", "id": "reaction_10617807", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10617835": { "compartment": "compartment_17951", "id": "reaction_10617835", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_390271" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10617832", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10617845": { "compartment": "compartment_17951", "id": "reaction_10617845", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_353123" ], "products": [ "species_193514", "species_390287" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10617843": { "compartment": "compartment_17951", "id": "reaction_10617843", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_192314" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10610040": { "compartment": "compartment_70101", "id": "reaction_10610040", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10610037", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10610751": { "compartment": "compartment_70101", "id": "reaction_10610751", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196420" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610020": { "compartment": "compartment_70101", "id": "reaction_10610020", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10610017", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10661829": { "compartment": "compartment_70101", "id": "reaction_10661829", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10661826", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10642772": { "compartment": "compartment_17957", "id": "reaction_10642772", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10642769", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10610030": { "compartment": "compartment_70101", "id": "reaction_10610030", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10610027", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10610012": { "compartment": "compartment_70101", "id": "reaction_10610012", "reactome": "R-CEL-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10610050": { "compartment": "compartment_70101", "id": "reaction_10610050", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10610047", "catalyst" ] ], "additional_components": [ "G5EFQ1", "WBGene00019460", "species_109496" ] }, "reaction_10666341": { "compartment": "compartment_12045", "id": "reaction_10666341", "reactome": "R-CEL-9755937", "name": "DHCR24 reduces LAN to 24,25-dhLAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634" ], "products": [ "species_29366", "species_1130708" ], "modifiers": [ [ "species_10610748", "catalyst" ], [ "species_10666337", "catalyst" ] ], "additional_components": [ "WBGene00018718", "WBGene00004735" ] }, "reaction_10610068": { "compartment": "compartment_70101", "id": "reaction_10610068", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10610065", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10610060": { "compartment": "compartment_70101", "id": "reaction_10610060", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10610057", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10655790": { "compartment": "compartment_12045", "id": "reaction_10655790", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_29366", "species_6807048" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610015": { "compartment": "compartment_70101", "id": "reaction_10610015", "reactome": "R-CEL-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10655788": { "compartment": "compartment_12045", "id": "reaction_10655788", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6807057" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10610743": { "compartment": "compartment_70101", "id": "reaction_10610743", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_195655" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10638184": { "compartment": "compartment_7660", "id": "reaction_10638184", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638084", "species_10638173" ], "products": [ "species_10638181", "species_10638069" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10655749": { "compartment": "compartment_984", "id": "reaction_10655749", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614867" ], "products": [ "species_10655694" ], "modifiers": [], "additional_components": [ "WBGene00001972", "WBGene00001972" ] }, "reaction_10655698": { "compartment": "compartment_984", "id": "reaction_10655698", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_181015" ], "products": [ "species_10655696" ], "modifiers": [], "additional_components": [ "WBGene00001972", "Q09390", "WBGene00001972", "species_181015" ] }, "reaction_10659495": { "compartment": "compartment_984", "id": "reaction_10659495", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10607100" ], "products": [ "species_10659493" ], "modifiers": [], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_2186967", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563" ] }, "reaction_10655702": { "compartment": "compartment_984", "id": "reaction_10655702", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_166005" ], "products": [ "species_10655700" ], "modifiers": [], "additional_components": [ "WBGene00001972", "species_166005", "Q09390", "WBGene00001972" ] }, "reaction_10607106": { "compartment": "compartment_984", "id": "reaction_10607106", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607100", "species_166005" ], "products": [ "species_10607102" ], "modifiers": [ [ "species_10607104", "inhibitor" ] ], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_166005", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "WBGene00022627" ] }, "reaction_10661651": { "compartment": "compartment_70101", "id": "reaction_10661651", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661647" ], "products": [ "species_10661649" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661665": { "compartment": "compartment_70101", "id": "reaction_10661665", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625310", "species_10628559" ], "products": [ "species_10628565" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661629": { "compartment": "compartment_70101", "id": "reaction_10661629", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661619" ], "products": [ "species_10661627" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661661": { "compartment": "compartment_70101", "id": "reaction_10661661", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661617" ], "products": [ "species_10661619" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661659": { "compartment": "compartment_70101", "id": "reaction_10661659", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628565" ], "products": [ "species_10628577" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10611863": { "compartment": "compartment_70101", "id": "reaction_10611863", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611857" ], "products": [ "species_10611861", "species_10611859" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000072", "WBGene00000072", "WBGene00000072", "P42573", "WBGene00000417" ] }, "reaction_10611874": { "compartment": "compartment_70101", "id": "reaction_10611874", "reactome": "R-CEL-201622", "name": "Caspase-mediated cleavage of gelsolin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611868" ], "products": [ "species_10611870", "species_10611872" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010593", "WBGene00010593", "WBGene00010593", "P42573", "WBGene00000417" ] }, "reaction_10612305": { "compartment": "compartment_70101", "id": "reaction_10612305", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612299" ], "products": [ "species_10612303", "species_10612301" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10612294": { "compartment": "compartment_70101", "id": "reaction_10612294", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612288" ], "products": [ "species_10612290", "species_10612292" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10636129": { "compartment": "compartment_161320", "id": "reaction_10636129", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_1678868", "species_2162223" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10665108": { "compartment": "compartment_161320", "id": "reaction_10665108", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636011": { "compartment": "compartment_161320", "id": "reaction_10636011", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160864", "species_1605715" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10636127": { "compartment": "compartment_161320", "id": "reaction_10636127", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162224", "species_1605715" ], "products": [ "species_1678868", "species_1678743" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10636032": { "compartment": "compartment_876", "id": "reaction_10636032", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636029" ], "products": [ "species_2160894", "species_10636029" ], "modifiers": [ [ "species_10636029", "catalyst" ] ], "additional_components": [ "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10636125": { "compartment": "compartment_161320", "id": "reaction_10636125", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10609537": { "compartment": "compartment_7660", "id": "reaction_10609537", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609448" ], "products": [ "species_10598143", "species_10609440", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609431": { "compartment": "compartment_7660", "id": "reaction_10609431", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609423" ], "products": [ "species_113582", "species_10609428" ], "modifiers": [ [ "species_10609423", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598270": { "compartment": "compartment_7660", "id": "reaction_10598270", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598260" ], "products": [ "species_10598262" ], "modifiers": [ [ "species_10598267", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00000794" ] }, "reaction_10609442": { "compartment": "compartment_7660", "id": "reaction_10609442", "reactome": "R-CEL-187545", "name": "Association of Cks1 with SCF(Skp2) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609433", "species_10609438" ], "products": [ "species_10609440" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "WBGene00001051", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10598156": { "compartment": "compartment_70101", "id": "reaction_10598156", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598154" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P91155", "WBGene00000382", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609606": { "compartment": "compartment_7660", "id": "reaction_10609606", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609602" ], "products": [ "species_113582", "species_10609604" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609421": { "compartment": "compartment_13231", "id": "reaction_10609421", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419" ], "products": [ "species_10598355" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10598146": { "compartment": "compartment_7660", "id": "reaction_10598146", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597697" ], "products": [ "species_113582", "species_10598123" ], "modifiers": [ [ "species_10598143", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597902": { "compartment": "compartment_7660", "id": "reaction_10597902", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597874", "species_10597841" ], "products": [ "species_10597877" ], "modifiers": [ [ "species_10597899", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00012650", "WBGene00012650", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10598204": { "compartment": "compartment_7660", "id": "reaction_10598204", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598198" ], "products": [ "species_10598185", "species_10598202" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10608079": { "compartment": "compartment_13231", "id": "reaction_10608079", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607961" ], "products": [ "species_10607975" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609540": { "compartment": "compartment_7660", "id": "reaction_10609540", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609444", "species_10597874" ], "products": [ "species_10609448" ], "modifiers": [ [ "species_10609444", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051", "WBGene00006727", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598158": { "compartment": "compartment_7660", "id": "reaction_10598158", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597820" ], "products": [ "species_10597811", "species_10597804", "species_10597787", "species_10597816" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "WBGene00003157" ] }, "reaction_10598150": { "compartment": "compartment_7660", "id": "reaction_10598150", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598123" ], "products": [ "species_10598148" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10636953": { "compartment": "compartment_7660", "id": "reaction_10636953", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636933", "species_113560" ], "products": [ "species_2485002", "species_10636941" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10597749": { "compartment": "compartment_7660", "id": "reaction_10597749", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10597744" ], "products": [ "species_10597740", "species_10597746" ], "modifiers": [ [ "species_10597744", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10598258": { "compartment": "compartment_7660", "id": "reaction_10598258", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598249", "species_10598254" ], "products": [ "species_10598256" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00001016", "Q9U3F2", "WBGene00001016", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10610968": { "compartment": "compartment_70101", "id": "reaction_10610968", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419", "species_113592" ], "products": [ "species_29370", "species_10610965" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10597906": { "compartment": "compartment_7660", "id": "reaction_10597906", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597877" ], "products": [ "species_10597904" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10636990": { "compartment": "compartment_7660", "id": "reaction_10636990", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636986", "species_113560" ], "products": [ "species_2485002", "species_10636988" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10598189": { "compartment": "compartment_7660", "id": "reaction_10598189", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113", "species_10598185" ], "products": [ "species_10598187" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10598200": { "compartment": "compartment_7660", "id": "reaction_10598200", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598196", "species_10598187" ], "products": [ "species_113582", "species_10598198" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10608402": { "compartment": "compartment_7660", "id": "reaction_10608402", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608388", "species_10608383", "species_10608393", "species_10608398" ], "products": [ "species_10608400" ], "modifiers": [], "additional_components": [ "WBGene00009287", "WBGene00011275", "WBGene00022043", "WBGene00013768", "Q9U2W9", "WBGene00013768", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043", "Q22019", "WBGene00011275" ] }, "reaction_10598232": { "compartment": "compartment_7660", "id": "reaction_10598232", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598225" ], "products": [ "species_10598229" ], "modifiers": [ [ "species_10598223", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645" ] }, "reaction_10607963": { "compartment": "compartment_70101", "id": "reaction_10607963", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10607594" ], "products": [ "species_10607961" ], "modifiers": [], "additional_components": [ "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609608": { "compartment": "compartment_7660", "id": "reaction_10609608", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_29358" ], "products": [ "species_113582", "species_10597866" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10598278": { "compartment": "compartment_7660", "id": "reaction_10598278", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10609598": { "compartment": "compartment_7660", "id": "reaction_10609598", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609593" ], "products": [ "species_113582", "species_10609595" ], "modifiers": [ [ "species_10609593", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598116": { "compartment": "compartment_7660", "id": "reaction_10598116", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10597746", "species_29604", "species_29892" ], "products": [ "species_10598113" ], "modifiers": [ [ "species_10597721", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10597869": { "compartment": "compartment_7660", "id": "reaction_10597869", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597822" ], "products": [ "species_10597845", "species_113582", "species_10597841" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00012650", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609446": { "compartment": "compartment_7660", "id": "reaction_10609446", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10609428" ], "products": [ "species_10609444" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598227": { "compartment": "compartment_7660", "id": "reaction_10598227", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598202", "species_10598223" ], "products": [ "species_10598225" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598236": { "compartment": "compartment_7660", "id": "reaction_10598236", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598229" ], "products": [ "species_10598234" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598111": { "compartment": "compartment_70101", "id": "reaction_10598111", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597904" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00012650", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607697": { "compartment": "compartment_876", "id": "reaction_10607697", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607678" ], "products": [ "species_10607692", "species_29372" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607687": { "compartment": "compartment_876", "id": "reaction_10607687", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607685" ], "products": [ "species_10607683", "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10608410": { "compartment": "compartment_70101", "id": "reaction_10608410", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608404" ], "products": [ "species_29370", "species_10608407" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10607674": { "compartment": "compartment_876", "id": "reaction_10607674", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607671", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "species_29420", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607694": { "compartment": "compartment_876", "id": "reaction_10607694", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607692" ], "products": [ "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10607216": { "compartment": "compartment_70101", "id": "reaction_10607216", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607202" ], "products": [ "species_10607214", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "species_29420", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681" ] }, "reaction_10607219": { "compartment": "compartment_70101", "id": "reaction_10607219", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607214" ], "products": [ "species_10605068" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "G5ECT6", "WBGene00001682", "Q09502", "WBGene00008065", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_29438", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "WBGene00001196" ] }, "reaction_10604848": { "compartment": "compartment_70101", "id": "reaction_10604848", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10607198": { "compartment": "compartment_947587", "id": "reaction_10607198", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843", "species_29420" ], "products": [ "species_29438", "species_10604969" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "WBGene00001196" ] }, "reaction_10665289": { "compartment": "compartment_70101", "id": "reaction_10665289", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10608407", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10604971": { "compartment": "compartment_70101", "id": "reaction_10604971", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604845", "species_29356" ], "products": [ "species_10604832", "species_10604969", "species_29372" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "WBGene00001177", "species_29420", "G5EGU1", "WBGene00001196" ] }, "reaction_10607700": { "compartment": "compartment_876", "id": "reaction_10607700", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607685", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10604931": { "compartment": "compartment_70101", "id": "reaction_10604931", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10607690": { "compartment": "compartment_876", "id": "reaction_10607690", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607221": { "compartment": "compartment_947587", "id": "reaction_10607221", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604969", "species_10605064" ], "products": [ "species_10607200" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10607676": { "compartment": "compartment_876", "id": "reaction_10607676", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607665", "species_10607647" ], "products": [ "species_10607667" ], "modifiers": [], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "species_109496", "Q9N2V6", "WBGene00001678", "Q966F9", "WBGene00000071", "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607681": { "compartment": "compartment_876", "id": "reaction_10607681", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607647", "species_10604895" ], "products": [ "species_10607678" ], "modifiers": [ [ "species_10604895", "catalyst" ] ], "additional_components": [ "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071" ] }, "reaction_10628746": { "compartment": "compartment_1222693", "id": "reaction_10628746", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10628743", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10650440": { "compartment": "compartment_21994", "id": "reaction_10650440", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10650430" ], "products": [ "species_10650432" ], "modifiers": [], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650435": { "compartment": "compartment_21994", "id": "reaction_10650435", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650432", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10658173": { "compartment": "compartment_984", "id": "reaction_10658173", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10658170", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650438": { "compartment": "compartment_1222282", "id": "reaction_10650438", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10660758": { "compartment": "compartment_1222282", "id": "reaction_10660758", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10621247": { "compartment": "compartment_172574", "id": "reaction_10621247", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10621244", "catalyst" ] ], "additional_components": [ "species_216667", "species_113531", "species_266099", "species_216667", "species_113531", "species_266099", "Q21434", "WBGene00004876", "Q21433", "WBGene00004877", "Q95XG8", "WBGene00004878" ] }, "reaction_10664718": { "compartment": "compartment_70101", "id": "reaction_10664718", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647011", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665968": { "compartment": "compartment_7660", "id": "reaction_10665968", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611187" ], "products": [ "species_10664881" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10665966": { "compartment": "compartment_7660", "id": "reaction_10665966", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662906": { "compartment": "compartment_876", "id": "reaction_10662906", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10662895" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10636260": { "compartment": "compartment_70101", "id": "reaction_10636260", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10636257", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10624986": { "compartment": "compartment_876", "id": "reaction_10624986", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605064", "species_10607683" ], "products": [ "species_10616840" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10655747": { "compartment": "compartment_984", "id": "reaction_10655747", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6805204", "species_10655743" ], "products": [ "species_10655745" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_6805204" ] }, "reaction_10624999": { "compartment": "compartment_876", "id": "reaction_10624999", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618849", "species_10605064" ], "products": [ "species_10605451" ], "modifiers": [], "additional_components": [ "species_111349", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616840", "species_10616838" ], "products": [ "species_10616842" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794" ] }, "reaction_10618991": { "compartment": "compartment_984", "id": "reaction_10618991", "reactome": "R-CEL-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616818", "species_419339" ], "products": [ "species_10616820" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "species_419339", "P91439", "WBGene00020319", "O76667", "WBGene00019183" ] }, "reaction_10666012": { "compartment": "compartment_70101", "id": "reaction_10666012", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10666009", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10617905": { "compartment": "compartment_984", "id": "reaction_10617905", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616408", "species_114523" ], "products": [ "species_10616410" ], "modifiers": [], "additional_components": [ "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "species_114523" ] }, "reaction_10617893": { "compartment": "compartment_984", "id": "reaction_10617893", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10616744" ], "products": [ "species_10616748" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10662902": { "compartment": "compartment_876", "id": "reaction_10662902", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662899" ], "products": [ "species_10662895" ], "modifiers": [ [ "species_10662899", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10666056": { "compartment": "compartment_70101", "id": "reaction_10666056", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10617968": { "compartment": "compartment_984", "id": "reaction_10617968", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616790", "species_416911" ], "products": [ "species_10616792" ], "modifiers": [], "additional_components": [ "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_879629", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086" ] }, "reaction_10636281": { "compartment": "compartment_876", "id": "reaction_10636281", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636278" ], "products": [ "species_10630578" ], "modifiers": [ [ "species_10618504", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624788": { "compartment": "compartment_876", "id": "reaction_10624788", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616656", "species_10605486" ], "products": [ "species_10616658" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "species_205687", "CHEBI:15650", "species_266074", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "species_74016", "CHEBI:28875", "species_113552", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794" ] }, "reaction_10651371": { "compartment": "compartment_876", "id": "reaction_10651371", "reactome": "R-CEL-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10651368", "catalyst" ] ], "additional_components": [ "WBGene00011524" ] }, "reaction_10621741": { "compartment": "compartment_984", "id": "reaction_10621741", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10621737" ], "products": [ "species_10621739" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "G5ECX0", "WBGene00002252", "species_444761", "Q19930", "WBGene00017947" ] }, "reaction_10624997": { "compartment": "compartment_70101", "id": "reaction_10624997", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624992" ], "products": [ "species_10624988", "species_29420" ], "modifiers": [ [ "species_10624992", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618959": { "compartment": "compartment_984", "id": "reaction_10618959", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_417888" ], "products": [ "species_10616605" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_205687" ] }, "reaction_10663247": { "compartment": "compartment_876", "id": "reaction_10663247", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663242" ], "products": [ "species_10663229", "species_10605484" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_111349" ] }, "reaction_10618506": { "compartment": "compartment_876", "id": "reaction_10618506", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604943", "species_114519" ], "products": [ "species_10618504" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624961": { "compartment": "compartment_984", "id": "reaction_10624961", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616660" ], "products": [ "species_10605064", "species_10624953", "species_10624959", "species_10604843" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q95YD7", "WBGene00016265", "O62403", "WBGene00013782", "O44536", "WBGene00019224", "O18014", "WBGene00011381", "G5EBX8", "WBGene00008890", "A0A3B1DQQ4", "WBGene00006864", "O17239", "WBGene00019616", "Q09502", "WBGene00008065", "O44731", "WBGene00018798", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "Q23265", "WBGene00013871", "Q20841", "WBGene00018886", "Q09638", "WBGene00012084", "Q23497", "WBGene00013974", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "Q20325", "WBGene00018344", "H9G358", "WBGene00018089", "G5EDI0", "WBGene00007395", "A0A0K3AYF5", "C16D6.2b", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "A0A2C9C3A4", "WBGene00018089", "Q18130", "WBGene00016044", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q9XVS5", "WBGene00007614", "Q18701", "WBGene00016747", "A0A0K3AXD3", "WBGene00011372", "Q19399", "WBGene00008736", "Q03566", "WBGene00006576", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "P91096", "WBGene00016037", "Q23033", "WBGene00020086", "CHEBI:6498", "species_374935", "CHEBI:28364", "species_29370", "CHEBI:30772", "species_265287", "CHEBI:53460", "species_8869214", "species_2046056", "species_427486", "CHEBI:53487", "CHEBI:17120", "species_205687", "CHEBI:15650", "species_390899", "Q93518", "WBGene00008879", "species_216667", "CHEBI:50122", "species_113552", "CHEBI:30212", "species_29460", "CHEBI:28716", "species_29468", "CHEBI:42504", "species_264643", "species_2066763", "species_8934421", "species_390435", "species_879535", "species_29444", "CHEBI:15627", "species_209849", "CHEBI:30768", "species_266074", "CHEBI:30805", "CHEBI:16196", "Q10651", "WBGene00000149", "species_74016", "CHEBI:28875", "species_70106", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "species_113585", "CHEBI:27997", "species_113592", "CHEBI:31011", "species_266056", "species_209794", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618957": { "compartment": "compartment_984", "id": "reaction_10618957", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10616766" ], "products": [ "species_10616768" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10618961": { "compartment": "compartment_984", "id": "reaction_10618961", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616447", "species_83908" ], "products": [ "species_10616449" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10665053": { "compartment": "compartment_70101", "id": "reaction_10665053", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10665050", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10605432": { "compartment": "compartment_70101", "id": "reaction_10605432", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10605429", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10615432": { "compartment": "compartment_984", "id": "reaction_10615432", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615428", "species_210382" ], "products": [ "species_10615430" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "species_113552", "Q09630", "WBGene00003232" ] }, "reaction_10617972": { "compartment": "compartment_984", "id": "reaction_10617972", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616631", "species_416436" ], "products": [ "species_10616633" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "species_266056", "Q9XVS5", "WBGene00007614" ] }, "reaction_10664924": { "compartment": "compartment_984", "id": "reaction_10664924", "reactome": "R-CEL-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615597", "species_9615246" ], "products": [ "species_10664922" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=587", "LigandDisplayForward?ligandId=592", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590", "LigandDisplayForward?ligandId=587", "Q09638", "WBGene00012084", "LigandDisplayForward?ligandId=592", "O18014", "WBGene00011381", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590" ] }, "reaction_10617895": { "compartment": "compartment_984", "id": "reaction_10617895", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10616718" ], "products": [ "species_10616720" ], "modifiers": [], "additional_components": [ "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506", "species_380873", "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506" ] }, "reaction_10618573": { "compartment": "compartment_876", "id": "reaction_10618573", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604843" ], "products": [ "species_10618571" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "Q09639", "WBGene00001709", "species_29438" ] }, "reaction_10605434": { "compartment": "compartment_70101", "id": "reaction_10605434", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605415", "species_10605427" ], "products": [ "species_10605429" ], "modifiers": [], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10616856": { "compartment": "compartment_947587", "id": "reaction_10616856", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616842" ], "products": [ "species_29420", "species_10616846" ], "modifiers": [ [ "species_10616842", "catalyst" ], [ "species_10616852", "inhibitor" ] ], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "WBGene00000092" ] }, "reaction_10617897": { "compartment": "compartment_984", "id": "reaction_10617897", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616704" ], "products": [ "species_10616706" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10616667": { "compartment": "compartment_70101", "id": "reaction_10616667", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616658" ], "products": [ "species_10616660", "species_29420" ], "modifiers": [ [ "species_10616664", "catalyst" ] ], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10662889": { "compartment": "compartment_70101", "id": "reaction_10662889", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662884" ], "products": [ "species_10607663", "species_10662882" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "WBGene00005077" ] }, "reaction_10617899": { "compartment": "compartment_984", "id": "reaction_10617899", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616392" ], "products": [ "species_10616394" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10624984": { "compartment": "compartment_876", "id": "reaction_10624984", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605484", "species_10605064" ], "products": [ "species_10605486" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_111349", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618928": { "compartment": "compartment_876", "id": "reaction_10618928", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843" ], "products": [ "species_10605484" ], "modifiers": [ [ "species_10604843", "catalyst" ], [ "species_10618926", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "species_111349", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10624980": { "compartment": "compartment_984", "id": "reaction_10624980", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616846" ], "products": [ "species_10607663", "species_10605064", "species_10616838" ], "modifiers": [], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086" ] }, "reaction_10621705": { "compartment": "compartment_984", "id": "reaction_10621705", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10616641" ], "products": [ "species_10616645" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10625140": { "compartment": "compartment_876", "id": "reaction_10625140", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621723", "species_10625136" ], "products": [ "species_10625138" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q18849", "WBGene00008314", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "Q19930", "WBGene00017947" ] }, "reaction_10617970": { "compartment": "compartment_984", "id": "reaction_10617970", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_416372" ], "products": [ "species_10616770" ], "modifiers": [], "additional_components": [ "WBGene00016570", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "H2KZ99", "WBGene00016570" ] }, "reaction_10624978": { "compartment": "compartment_70101", "id": "reaction_10624978", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624969" ], "products": [ "species_10624975", "species_29420" ], "modifiers": [ [ "species_10624969", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_29438", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618852": { "compartment": "compartment_876", "id": "reaction_10618852", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618112" ], "products": [ "species_10618849" ], "modifiers": [ [ "species_10618112", "catalyst" ] ], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "species_111349", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674" ] }, "reaction_10617962": { "compartment": "compartment_984", "id": "reaction_10617962", "reactome": "R-CEL-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616424", "species_10616415" ], "products": [ "species_10616426" ], "modifiers": [], "additional_components": [ "Q21013", "WBGene00001466", "A7DT38", "WBGene00020722", "WBGene00008239", "Q21013", "WBGene00001466", "L8EC40", "WBGene00008239", "A7DT38", "WBGene00020722" ] }, "reaction_10618729": { "compartment": "compartment_984", "id": "reaction_10618729", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616552", "species_417891" ], "products": [ "species_10616554" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10618847": { "compartment": "compartment_70101", "id": "reaction_10618847", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10618844", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "O18696", "WBGene00011433", "Q9N2V9", "WBGene00022389", "P91119", "WBGene00016328" ] }, "reaction_10617901": { "compartment": "compartment_984", "id": "reaction_10617901", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616700", "species_114523" ], "products": [ "species_10616702" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10665554": { "compartment": "compartment_984", "id": "reaction_10665554", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665550", "species_380873" ], "products": [ "species_10665552" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_380873", "Q6RYS9", "WBGene00020506" ] }, "reaction_10617889": { "compartment": "compartment_984", "id": "reaction_10617889", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616508", "species_372533" ], "products": [ "species_10616514" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10618733": { "compartment": "compartment_984", "id": "reaction_10618733", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616548", "species_417891" ], "products": [ "species_10616550" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662897": { "compartment": "compartment_876", "id": "reaction_10662897", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10608724", "species_10613387", "species_10605064", "species_10617723" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "WBGene00010776", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "WBGene00003911" ] }, "reaction_10617974": { "compartment": "compartment_984", "id": "reaction_10617974", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616599", "species_416372" ], "products": [ "species_10616601" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "Q23265", "WBGene00013871", "CHEBI:15650", "species_266074", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10617903": { "compartment": "compartment_984", "id": "reaction_10617903", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616544", "species_114523" ], "products": [ "species_10616546" ], "modifiers": [], "additional_components": [ "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "species_114523" ] }, "reaction_10665773": { "compartment": "compartment_984", "id": "reaction_10665773", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_9684615" ], "products": [ "species_10665771" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=3634", "LigandDisplayForward?ligandId=5861", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10665777": { "compartment": "compartment_984", "id": "reaction_10665777", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_416372" ], "products": [ "species_10616587" ], "modifiers": [ [ "species_10665771", "inhibitor" ] ], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10605534": { "compartment": "compartment_876", "id": "reaction_10605534", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605529" ], "products": [ "species_10605531" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "species_179856", "species_114520", "G5EGU1", "WBGene00001196", "species_114519", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10663233": { "compartment": "compartment_876", "id": "reaction_10663233", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663229", "species_10604843" ], "products": [ "species_10663231" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10662887": { "compartment": "compartment_876", "id": "reaction_10662887", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10662879" ], "products": [ "species_29370", "species_10662884" ], "modifiers": [ [ "species_10662879", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665804": { "compartment": "compartment_984", "id": "reaction_10665804", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10665800" ], "products": [ "species_10665802" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10617640": { "compartment": "compartment_984", "id": "reaction_10617640", "reactome": "R-CEL-389463", "name": "Proteinase-activated receptors can bind thrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616635", "species_10605556" ], "products": [ "species_10616639" ], "modifiers": [], "additional_components": [ "WBGene00016570", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "species_74016" ] }, "reaction_10618989": { "compartment": "compartment_70101", "id": "reaction_10618989", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10662908": { "compartment": "compartment_70101", "id": "reaction_10662908", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10617723" ], "products": [ "species_10662891" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003911", "Q21430", "WBGene00010776", "Q17850", "WBGene00003911" ] }, "reaction_10662910": { "compartment": "compartment_876", "id": "reaction_10662910", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608722", "species_10662893" ], "products": [ "species_10662899" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10663227": { "compartment": "compartment_876", "id": "reaction_10663227", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663225" ], "products": [ "species_10663223", "species_10607683" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678" ] }, "reaction_10664441": { "compartment": "compartment_70101", "id": "reaction_10664441", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838", "species_10612150" ], "products": [ "species_10664439" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "WBGene00021022", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10663245": { "compartment": "compartment_876", "id": "reaction_10663245", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663231" ], "products": [ "species_10663242", "species_29372" ], "modifiers": [ [ "species_10663231", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10621703": { "compartment": "compartment_984", "id": "reaction_10621703", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10616457" ], "products": [ "species_10616459" ], "modifiers": [], "additional_components": [ "CHEBI:16755", "species_176655", "species_5357505", "species_193451", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "CHEBI:16755", "species_176655", "species_5357505", "Q19779", "WBGene00017779", "species_193451", "Q19295", "WBGene00017338" ] }, "reaction_10619074": { "compartment": "compartment_876", "id": "reaction_10619074", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10616834" ], "products": [ "species_10616836" ], "modifiers": [], "additional_components": [ "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10624994": { "compartment": "compartment_876", "id": "reaction_10624994", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605451", "species_10616523" ], "products": [ "species_10624992" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618118": { "compartment": "compartment_70101", "id": "reaction_10618118", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613395", "species_10618112" ], "products": [ "species_10618116" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663240": { "compartment": "compartment_876", "id": "reaction_10663240", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663235" ], "products": [ "species_10663225", "species_29372" ], "modifiers": [ [ "species_10663235", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665930": { "compartment": "compartment_984", "id": "reaction_10665930", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665926", "species_114523" ], "products": [ "species_10665928" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10618047": { "compartment": "compartment_70101", "id": "reaction_10618047", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10618044", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618122": { "compartment": "compartment_876", "id": "reaction_10618122", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618116", "species_10615544" ], "products": [ "species_10618120" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663237": { "compartment": "compartment_876", "id": "reaction_10663237", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663223", "species_10607663" ], "products": [ "species_10663235" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10616503": { "compartment": "compartment_70101", "id": "reaction_10616503", "reactome": "R-CEL-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616494" ], "products": [ "species_10616500", "species_29420" ], "modifiers": [ [ "species_10616494", "catalyst" ] ], "additional_components": [ "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_29438", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183" ] }, "reaction_10624990": { "compartment": "compartment_984", "id": "reaction_10624990", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624988" ], "products": [ "species_10618112", "species_791498", "species_10616519", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_374935", "species_209794", "CHEBI:15627", "WBGene00008890", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618731": { "compartment": "compartment_984", "id": "reaction_10618731", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616556", "species_417891" ], "products": [ "species_10616558" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662904": { "compartment": "compartment_70101", "id": "reaction_10662904", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662891", "species_10605064" ], "products": [ "species_10662893" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10647117": { "compartment": "compartment_70101", "id": "reaction_10647117", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646873" ], "products": [ "species_29370", "species_10647115" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10647434": { "compartment": "compartment_70101", "id": "reaction_10647434", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647395", "species_10647430" ], "products": [ "species_10647432" ], "modifiers": [], "additional_components": [ "WBGene00002982", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647477": { "compartment": "compartment_70101", "id": "reaction_10647477", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647430", "species_10647369" ], "products": [ "species_10647441" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882" ] }, "reaction_10647419": { "compartment": "compartment_70101", "id": "reaction_10647419", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647417" ], "products": [ "species_10646885", "species_29370" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647288": { "compartment": "compartment_70101", "id": "reaction_10647288", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646856", "species_113592" ], "products": [ "species_29370", "species_10647285" ], "modifiers": [ [ "species_10646856", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646893": { "compartment": "compartment_17938", "id": "reaction_10646893", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10646897": { "compartment": "compartment_70101", "id": "reaction_10646897", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10606957" ], "products": [ "species_10646861" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647615": { "compartment": "compartment_70101", "id": "reaction_10647615", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647445" ], "products": [ "species_10647430", "species_10647377" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922" ] }, "reaction_10647545": { "compartment": "compartment_12045", "id": "reaction_10647545", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646885" ], "products": [ "species_10647536" ], "modifiers": [ [ "species_10647541", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "WBGene00020706" ] }, "reaction_10646859": { "compartment": "compartment_70101", "id": "reaction_10646859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646624", "species_113592" ], "products": [ "species_29370", "species_10646856" ], "modifiers": [ [ "species_10646624", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646627": { "compartment": "compartment_70101", "id": "reaction_10646627", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646614" ], "products": [ "species_29370", "species_10646624" ], "modifiers": [ [ "species_10646614", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647428": { "compartment": "compartment_70101", "id": "reaction_10647428", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632839" ], "products": [ "species_10647417" ], "modifiers": [], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10632894": { "compartment": "compartment_70101", "id": "reaction_10632894", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10632841" ], "products": [ "species_29370", "species_10632847" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q23669", "WBGene00014151", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647448": { "compartment": "compartment_70101", "id": "reaction_10647448", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647443" ], "products": [ "species_10647445" ], "modifiers": [ [ "species_10647443", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10647409": { "compartment": "compartment_70101", "id": "reaction_10647409", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647377", "species_5681998" ], "products": [ "species_10647379", "species_10647381" ], "modifiers": [ [ "species_10647406", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "WBGene00021922", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10647424": { "compartment": "compartment_70101", "id": "reaction_10647424", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647285" ], "products": [ "species_10632891" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646878": { "compartment": "compartment_70101", "id": "reaction_10646878", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10617093" ], "products": [ "species_10646614" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647475": { "compartment": "compartment_70101", "id": "reaction_10647475", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647456" ], "products": [ "species_10647369" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647422": { "compartment": "compartment_70101", "id": "reaction_10647422", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10633217", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10664110": { "compartment": "compartment_70101", "id": "reaction_10664110", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647432" ], "products": [ "species_10647611" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647532": { "compartment": "compartment_70101", "id": "reaction_10647532", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647369", "species_5681998" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647613": { "compartment": "compartment_70101", "id": "reaction_10647613", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647381", "species_10647441" ], "products": [ "species_10647443" ], "modifiers": [], "additional_components": [ "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10646888": { "compartment": "compartment_12045", "id": "reaction_10646888", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10646885", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10647276": { "compartment": "compartment_74700", "id": "reaction_10647276", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647115" ], "products": [ "species_10606979", "species_10646871" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10647565": { "compartment": "compartment_5683628", "id": "reaction_10647565", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647556" ], "modifiers": [ [ "species_10647563", "catalyst" ], [ "species_10625721", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "A7DT33", "WBGene00021319", "Q9TXI7", "WBGene00006932", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216" ] }, "reaction_10647681": { "compartment": "compartment_70101", "id": "reaction_10647681", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646871" ], "products": [ "species_10646612", "species_29372" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10646876": { "compartment": "compartment_17938", "id": "reaction_10646876", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646861", "species_113592" ], "products": [ "species_29370", "species_10646873" ], "modifiers": [ [ "species_10646861", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647313": { "compartment": "compartment_70101", "id": "reaction_10647313", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647309", "species_5693050" ], "products": [ "species_10647311" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641", "species_1806200", "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641" ] }, "reaction_10647426": { "compartment": "compartment_70101", "id": "reaction_10647426", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647404", "species_10647402" ], "products": [ "species_10647406" ], "modifiers": [], "additional_components": [ "species_5334668", "O16466", "WBGene00018294", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q09406", "WBGene00019427", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10655850": { "compartment": "compartment_6791047", "id": "reaction_10655850", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10649186", "species_10655846" ], "products": [ "species_10655848" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713" ] }, "reaction_10655917": { "compartment": "compartment_6791047", "id": "reaction_10655917", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655913", "species_10655868" ], "products": [ "species_10655915" ], "modifiers": [], "additional_components": [ "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EGG0", "WBGene00010713" ] }, "reaction_10655871": { "compartment": "compartment_6791047", "id": "reaction_10655871", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10655864" ], "products": [ "species_29370", "species_10655868" ], "modifiers": [ [ "species_10655864", "catalyst" ] ], "additional_components": [ "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183" ] }, "reaction_10656339": { "compartment": "compartment_20699", "id": "reaction_10656339", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656335" ], "products": [ "species_10656337" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10656333": { "compartment": "compartment_20699", "id": "reaction_10656333", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656329", "species_10656314" ], "products": [ "species_10656331" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q95ZW1", "WBGene00017273", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20797", "WBGene00006373", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855" ] }, "reaction_10656176": { "compartment": "compartment_432051", "id": "reaction_10656176", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656172", "species_10656090" ], "products": [ "species_10656174" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "Q21408", "WBGene00004951", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q22328", "WBGene00002976", "G5EGG0", "WBGene00010713", "G5EFW3", "WBGene00004855", "Q09473", "WBGene00016195", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "G5EDD4", "WBGene00006530", "Q09236", "WBGene00015734", "G5EEU1", "WBGene00043064", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "G5EGG0", "WBGene00010713", "Q19020", "WBGene00000962", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "Q22328", "WBGene00002976", "G5EF01", "WBGene00006539", "G5EFW3", "WBGene00004855", "Q9NA98", "WBGene00013168", "O18154", "WBGene00006533", "O45087", "WBGene00015927", "Q9UAQ6", "WBGene00004266", "Q21408", "WBGene00004951", "species_29420", "Q18194", "WBGene00016124", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "P52275", "WBGene00006537", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9GYR2", "WBGene00016793", "species_29438", "Q9TXZ9", "WBGene00015164", "P12456", "WBGene00003171", "O62246", "WBGene00009732", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "P34685", "WBGene00000292", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "O17921", "WBGene00006536", "A0AAC1", "WBGene00012424" ] }, "reaction_10621209": { "compartment": "compartment_17906", "id": "reaction_10621209", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_200993" ], "modifiers": [ [ "species_10621206", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10650696": { "compartment": "compartment_7660", "id": "reaction_10650696", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650680" ], "products": [ "species_10650618" ], "modifiers": [ [ "species_10650605", "catalyst" ], [ "species_10650694", "catalyst" ], [ "species_10650610", "catalyst" ], [ "species_10650678", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "WBGene00012393", "Q95Y89", "WBGene00003063", "Q21086", "WBGene00003821", "Q09958", "WBGene00015941", "WBGene00010709", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893" ] }, "reaction_10650964": { "compartment": "compartment_7660", "id": "reaction_10650964", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650929" ], "products": [ "species_10650937" ], "modifiers": [ [ "species_10650961", "catalyst" ], [ "species_10650949", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "Q93830", "WBGene00010325", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "Q23223", "WBGene00012342", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "O16207", "WBGene00017916", "Q9N4P9", "WBGene00000202", "Q9XXD2", "WBGene00012966", "WBGene00000798", "WBGene00012342", "WBGene00000796" ] }, "reaction_10650652": { "compartment": "compartment_7660", "id": "reaction_10650652", "reactome": "R-CEL-6791218", "name": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650618" ], "products": [ "species_10601533" ], "modifiers": [ [ "species_10650645", "catalyst" ], [ "species_10650650", "catalyst" ], [ "species_10650623", "catalyst" ], [ "species_10650635", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ], [ "species_10650630", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00001332", "WBGene00012465", "WBGene00021785", "WBGene00017916", "WBGene00012342", "WBGene00000796", "WBGene00001001" ] }, "reaction_10651116": { "compartment": "compartment_7660", "id": "reaction_10651116", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651102" ], "products": [ "species_10651106" ], "modifiers": [ [ "species_10651111", "catalyst" ], [ "species_10650818", "catalyst" ], [ "species_10650794", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10651114", "catalyst" ], [ "species_10650772", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "WBGene00006964", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q95XY4", "WBGene00021789", "WBGene00015104", "WBGene00012342", "WBGene00004705", "A7DT40", "WBGene00045433", "Q9XUU8", "WBGene00010582", "Q9N477", "WBGene00021276", "Q23495", "WBGene00022739" ] }, "reaction_10663299": { "compartment": "compartment_70101", "id": "reaction_10663299", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663271" ], "products": [ "species_10663297" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663273": { "compartment": "compartment_70101", "id": "reaction_10663273", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263", "species_10663269" ], "products": [ "species_10663271" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10630255": { "compartment": "compartment_7660", "id": "reaction_10630255", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10628778" ], "products": [ "species_10630253" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00003020", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10665597": { "compartment": "compartment_70101", "id": "reaction_10665597", "reactome": "R-CEL-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665595" ], "products": [ "species_10598308" ], "modifiers": [], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10630260": { "compartment": "compartment_7660", "id": "reaction_10630260", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630253", "species_10597874" ], "products": [ "species_10630257", "species_10609440" ], "modifiers": [ [ "species_10630253", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "G5EDT1", "WBGene00003020", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10630229": { "compartment": "compartment_7660", "id": "reaction_10630229", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628790" ], "products": [ "species_113550", "species_10628782" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10630231": { "compartment": "compartment_7660", "id": "reaction_10630231", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628778" ], "products": [ "species_113550", "species_10628748" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10628604": { "compartment": "compartment_12045", "id": "reaction_10628604", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628597" ], "products": [ "species_74016", "species_10628599" ], "modifiers": [ [ "species_10628601", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "species_74016", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10635753": { "compartment": "compartment_12045", "id": "reaction_10635753", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635749", "species_10628599" ], "products": [ "species_10635751" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10635700": { "compartment": "compartment_876", "id": "reaction_10635700", "reactome": "R-CEL-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10635697", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q45FX5", "WBGene00006887", "G5EDP9", "WBGene00000001" ] }, "reaction_10635756": { "compartment": "compartment_70101", "id": "reaction_10635756", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10635751", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10611606": { "compartment": "compartment_876", "id": "reaction_10611606", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611656": { "compartment": "compartment_876", "id": "reaction_10611656", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611652": { "compartment": "compartment_70101", "id": "reaction_10611652", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10656006": { "compartment": "compartment_5460", "id": "reaction_10656006", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10656003", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10656014": { "compartment": "compartment_70101", "id": "reaction_10656014", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10656011", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10611619": { "compartment": "compartment_876", "id": "reaction_10611619", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10611616", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10611640": { "compartment": "compartment_70616", "id": "reaction_10611640", "reactome": "R-CEL-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10611637", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10611658": { "compartment": "compartment_70101", "id": "reaction_10611658", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611608": { "compartment": "compartment_70101", "id": "reaction_10611608", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611650": { "compartment": "compartment_70101", "id": "reaction_10611650", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611660": { "compartment": "compartment_70101", "id": "reaction_10611660", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10655553": { "compartment": "compartment_70101", "id": "reaction_10655553", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_70106", "species_29370", "species_200640", "species_29372" ], "modifiers": [ [ "species_10655550", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10655555": { "compartment": "compartment_5460", "id": "reaction_10655555", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611581": { "compartment": "compartment_70101", "id": "reaction_10611581", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10649581": { "compartment": "compartment_5460", "id": "reaction_10649581", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611632": { "compartment": "compartment_70101", "id": "reaction_10611632", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10611629", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10666081": { "compartment": "compartment_70101", "id": "reaction_10666081", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10666078", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10610864": { "compartment": "compartment_70101", "id": "reaction_10610864", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10611642": { "compartment": "compartment_70101", "id": "reaction_10611642", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10610862": { "compartment": "compartment_70101", "id": "reaction_10610862", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10610854": { "compartment": "compartment_70101", "id": "reaction_10610854", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611647": { "compartment": "compartment_5460", "id": "reaction_10611647", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10611644", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611622": { "compartment": "compartment_70101", "id": "reaction_10611622", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10602950": { "compartment": "compartment_7660", "id": "reaction_10602950", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602938" ], "products": [ "species_10602946" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602940": { "compartment": "compartment_7660", "id": "reaction_10602940", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602934" ], "products": [ "species_10602938" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602948": { "compartment": "compartment_7660", "id": "reaction_10602948", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602946" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10661007": { "compartment": "compartment_7660", "id": "reaction_10661007", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661003", "species_10658637" ], "products": [ "species_10661005" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "H2KYY1", "WBGene00016029", "G5EFQ5", "WBGene00004393" ] }, "reaction_10650030": { "compartment": "compartment_70101", "id": "reaction_10650030", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646645", "species_10650024" ], "products": [ "species_10650028" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10650026": { "compartment": "compartment_70101", "id": "reaction_10650026", "reactome": "R-CEL-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10650022" ], "products": [ "species_10650024" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00016500", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10656931": { "compartment": "compartment_70101", "id": "reaction_10656931", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656927", "species_10617956" ], "products": [ "species_10656929" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q20636", "WBGene00001680", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656937": { "compartment": "compartment_70101", "id": "reaction_10656937", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656935" ], "products": [ "species_10656929", "species_29372" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657582": { "compartment": "compartment_70101", "id": "reaction_10657582", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657580" ], "products": [ "species_10657558", "species_10656946" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142" ] }, "reaction_10657586": { "compartment": "compartment_70101", "id": "reaction_10657586", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657576" ], "products": [ "species_10657584", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10617960": { "compartment": "compartment_70101", "id": "reaction_10617960", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617912", "species_10617956" ], "products": [ "species_10617958" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q18425", "WBGene00007918", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656989": { "compartment": "compartment_70101", "id": "reaction_10656989", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656983", "species_10605048" ], "products": [ "species_10656987" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681" ] }, "reaction_10657556": { "compartment": "compartment_70101", "id": "reaction_10657556", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657554" ], "products": [ "species_10656983", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656981": { "compartment": "compartment_70101", "id": "reaction_10656981", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656979" ], "products": [ "species_29370", "species_10656946" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10656952": { "compartment": "compartment_70101", "id": "reaction_10656952", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_113592" ], "products": [ "species_29370", "species_10656935" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656950": { "compartment": "compartment_70101", "id": "reaction_10656950", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_10656946" ], "products": [ "species_10656948" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142", "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657590": { "compartment": "compartment_70101", "id": "reaction_10657590", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656987", "species_10604837" ], "products": [ "species_10657588", "species_10656946" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10657578": { "compartment": "compartment_70101", "id": "reaction_10657578", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657558", "species_10657574" ], "products": [ "species_10657576" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391" ] }, "reaction_10621270": { "compartment": "compartment_1462052", "id": "reaction_10621270", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621267", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10621299": { "compartment": "compartment_876", "id": "reaction_10621299", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10621296", "catalyst" ] ], "additional_components": [ "WBGene00017954" ] }, "reaction_10621278": { "compartment": "compartment_20699", "id": "reaction_10621278", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621275", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10621262": { "compartment": "compartment_876", "id": "reaction_10621262", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10621259", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621430": { "compartment": "compartment_876", "id": "reaction_10621430", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621427", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10621438": { "compartment": "compartment_12045", "id": "reaction_10621438", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621435", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10621254": { "compartment": "compartment_876", "id": "reaction_10621254", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10621251", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10662865": { "compartment": "compartment_70101", "id": "reaction_10662865", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10662862", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621286": { "compartment": "compartment_20699", "id": "reaction_10621286", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10621283", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10625287": { "compartment": "compartment_876", "id": "reaction_10625287", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10621419": { "compartment": "compartment_876", "id": "reaction_10621419", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10621507": { "compartment": "compartment_876", "id": "reaction_10621507", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10621504", "catalyst" ] ], "additional_components": [ "O44196", "WBGene00022682", "O02340", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10621483": { "compartment": "compartment_876", "id": "reaction_10621483", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621480", "catalyst" ] ], "additional_components": [ "P91348", "WBGene00018897", "Q9XWH3", "WBGene00013207", "O62192", "WBGene00009286", "Q22395", "WBGene00006486", "Q09957", "WBGene00015940", "Q6BEU0", "WBGene00014669", "U4PS08", "WBGene00021936", "Q19913", "WBGene00017936" ] }, "reaction_10621397": { "compartment": "compartment_876", "id": "reaction_10621397", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621394", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10606319": { "compartment": "compartment_13231", "id": "reaction_10606319", "reactome": "R-CEL-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604046" ], "products": [ "species_10606317" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10605966": { "compartment": "compartment_70101", "id": "reaction_10605966", "reactome": "R-CEL-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10605960" ], "products": [ "species_10602837", "species_10605964", "species_10602815" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00000122", "O61955", "WBGene00002061", "WBGene00003835", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600941": { "compartment": "compartment_7660", "id": "reaction_10600941", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600934" ], "products": [ "species_10600717", "species_10600755", "species_10600936", "species_10600767" ], "modifiers": [ [ "species_10600938", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q19864", "WBGene00000773", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q93716", "WBGene00009668", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "C1P629", "WBGene00008362", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93716", "WBGene00009668" ] }, "reaction_10602612": { "compartment": "compartment_7660", "id": "reaction_10602612", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602608" ], "products": [ "species_10602610", "species_10602600" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q9N5K2", "WBGene00019246", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916" ] }, "reaction_10602861": { "compartment": "compartment_70101", "id": "reaction_10602861", "reactome": "R-CEL-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602857" ], "products": [ "species_10602859", "species_10602825", "species_10602774" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "Q09601", "WBGene00003805", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q9XVS7", "WBGene00003834", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q86G90", "WBGene00003795", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "O01576", "WBGene00003797", "Q17561", "WBGene00000120", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "O62183", "WBGene00000121", "Q7K6X4", "WBGene00003802", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9BKT9", "WBGene00003799", "Q21155", "WBGene00004388", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "G5EEH9", "WBGene00003796", "Q9BL61", "WBGene00022029", "Q17561", "WBGene00000120", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q21832", "WBGene00004387", "O62183", "WBGene00000121", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600807": { "compartment": "compartment_7660", "id": "reaction_10600807", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600800" ], "products": [ "species_10600804", "species_10600794" ], "modifiers": [ [ "species_10600800", "catalyst" ] ], "additional_components": [ "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", 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"WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10605962": { "compartment": "compartment_13231", "id": "reaction_10605962", "reactome": "R-CEL-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604763" ], "products": [ "species_10605960" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600946": { "compartment": "compartment_7660", "id": "reaction_10600946", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600936" ], "products": [ "species_10600734", "species_10600943", "species_10600698", "species_10600739" ], "modifiers": [ [ "species_10600734", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10600830": { "compartment": "compartment_7660", "id": "reaction_10600830", "reactome": "R-CEL-72143", "name": "Lariat Formation and 5'-Splice Site Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600814", "species_10600804", "species_10600824", "species_10600812", "species_10600819" ], "products": [ "species_10600828" ], "modifiers": [], "additional_components": [ "WBGene00004705", "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", "Q19335", "WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", 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"P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q09385", "WBGene00019402", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q9U1Q3", "WBGene00000891", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10606328": { "compartment": "compartment_7660", "id": "reaction_10606328", "reactome": "R-CEL-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602797", "species_10600943" ], "products": [ "species_10606325", "species_113550", "species_10602803" ], "modifiers": [ [ "species_10600943", "catalyst" ] ], "additional_components": [ "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "species_29370", "Q18212", "WBGene00001840", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q9XVS7", "WBGene00003834", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "Q10667", "WBGene00004384", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384" ] }, "reaction_10604765": { "compartment": "compartment_7660", "id": "reaction_10604765", "reactome": "R-CEL-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600236", "species_10604757", "species_10602784" ], "products": [ "species_10604763", "species_10599886" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00003835", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600802": { "compartment": "compartment_7660", "id": "reaction_10600802", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600774", "species_10600769", "species_10600662", "species_10600794", "species_10600779", "species_10600789", "species_10600784" ], "products": [ "species_10600127", "species_10600591", "species_10600461", "species_10600586", "species_10600494", "species_10600800", "species_10600643", "species_10600533", "species_10600581" ], "modifiers": [], "additional_components": [ "WBGene00022029", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10021", "WBGene00004702", "Q9GRZ2", 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"Q9U2S6", "WBGene00000889", "Q8ITY4", "WBGene00016808", "Q22307", "WBGene00004355", "Q21322", "WBGene00004385", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "Q9XVS2", "WBGene00045383", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "Q9XUY1", "WBGene00010159", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "P91306", "WBGene00000473", "Q21739", "WBGene00011035", "Q9NLD1", "WBGene00002000", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "P91398", "WBGene00000474", "Q966L5", "WBGene00017085", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "P90815", "WBGene00017238", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9GR61", "WBGene00021347", "Q9XTZ2", "WBGene00004705", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O44787", "WBGene00017280", "Q9U1W8", "WBGene00003077", "P52018", "WBGene00000887", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q21486", "WBGene00010844", "O18694", "WBGene00003079", "Q20875", "WBGene00018967", "Q17336", "WBGene00002957", "Q93339", "WBGene00007972", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19952", "WBGene00003078", "Q95YF1", "WBGene00015581", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", 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"WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "Q9XXI7", "WBGene00000892", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", "Q95PY8", "WBGene00013460", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "Q966L5", "WBGene00017085", "P91398", "WBGene00000474", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776", "WBGene00008380", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "Q95XD4", "WBGene00003082", "O18694", "WBGene00003079", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "WBGene00017605" ] }, "reaction_10606323": { "compartment": "compartment_70101", "id": "reaction_10606323", "reactome": "R-CEL-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10606317" ], "products": [ "species_10602837", "species_10602815", "species_10606321" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "Q09599", "WBGene00000411", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10602614": { "compartment": "compartment_7660", "id": "reaction_10602614", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602610" ], "products": [ "species_10602610" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474" ] }, "reaction_10600948": { "compartment": "compartment_7660", "id": "reaction_10600948", "reactome": "R-CEL-72231", "name": "Formation of the Cleavage and Polyadenylation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10600755", "species_10600734", "species_10600767", "species_10600698", "species_10600739" ], "products": [ "species_10600769" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797" ] }, "reaction_10600664": { "compartment": "compartment_7660", "id": "reaction_10600664", "reactome": "R-CEL-72127", "name": "Formation of the Spliceosomal B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604042", "species_10600236", "species_10602784" ], "products": [ "species_10599879", "species_10599884", "species_10604046" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "WBGene00000122", "WBGene00003835", "WBGene00009141", "WBGene00018156", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10645511": { "compartment": "compartment_18730", "id": "reaction_10645511", "reactome": "R-CEL-5625421", "name": "The anterograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645507" ], "products": [ "species_10645492", "species_10645446", "species_10645410", "species_10645462", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10644779": { "compartment": "compartment_20699", "id": "reaction_10644779", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644777" ], "products": [ "species_10644775", "species_10644770" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10645519": { "compartment": "compartment_18730", "id": "reaction_10645519", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645496" ], "products": [ "species_10645515" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645509": { "compartment": "compartment_18730", "id": "reaction_10645509", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645390" ], "products": [ "species_10645507" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645392": { "compartment": "compartment_18730", "id": "reaction_10645392", "reactome": "R-CEL-5624949", "name": "Assembly of the anterograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645336", "species_10645291", "species_10645388", "species_10645216" ], "products": [ "species_10645390" ], "modifiers": [], "additional_components": [ "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P46873", "WBGene00003884", "P12456", "WBGene00003171", "Q19633", "WBGene00002222", "species_29420", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645498": { "compartment": "compartment_18730", "id": "reaction_10645498", "reactome": "R-CEL-5624952", "name": "Assembly of the retrograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645494", "species_10645446", "species_10645410", "species_10645462" ], "products": [ "species_10645496" ], "modifiers": [], "additional_components": [ "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "CHEBI:15996", "Q22799", "WBGene00001005", "P12456", "WBGene00003171", "species_29420", "Q22752", "WBGene00012004", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645517": { "compartment": "compartment_18730", "id": "reaction_10645517", "reactome": "R-CEL-5625424", "name": "The retrograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645515" ], "products": [ "species_10645336", "species_10645291", "species_10645216", "species_10645386", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10657713": { "compartment": "compartment_7660", "id": "reaction_10657713", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10657706", "species_10597874" ], "products": [ "species_10657711", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657810": { "compartment": "compartment_7660", "id": "reaction_10657810", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657770", "species_10657787" ], "products": [ "species_10657711", "species_10657808" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344" ] }, "reaction_10657815": { "compartment": "compartment_70101", "id": "reaction_10657815", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657717", "species_113592", "species_10597908" ], "products": [ "species_10657721", "species_111294" ], "modifiers": [ [ "species_10657717", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657812": { "compartment": "compartment_7660", "id": "reaction_10657812", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597874", "species_10657768" ], "products": [ "species_10657770", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657909": { "compartment": "compartment_70101", "id": "reaction_10657909", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657902" ], "products": [ "species_10601455", "species_10597908" ], "modifiers": [ [ "species_10657906", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00006727", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657821": { "compartment": "compartment_70101", "id": "reaction_10657821", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627924", "species_113592", "species_10597908" ], "products": [ "species_10657723", "species_111294" ], "modifiers": [ [ "species_10627924", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006699" ] }, "reaction_10657818": { "compartment": "compartment_70101", "id": "reaction_10657818", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657723" ], "products": [ "species_10657717", "species_76577" ], "modifiers": [ [ "species_10657723", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657823": { "compartment": "compartment_7660", "id": "reaction_10657823", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657711" ], "products": [ "species_164121", "species_10657768" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657766": { "compartment": "compartment_70101", "id": "reaction_10657766", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657715", "species_10657721" ], "products": [ "species_10657723", "species_10657764" ], "modifiers": [], "additional_components": [ "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10629119": { "compartment": "compartment_984", "id": "reaction_10629119", "reactome": "R-CEL-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10629164": { "compartment": "compartment_70101", "id": "reaction_10629164", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10630872": { "compartment": "compartment_70101", "id": "reaction_10630872", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10629166": { "compartment": "compartment_70101", "id": "reaction_10629166", "reactome": "R-CEL-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022", "species_425425" ], "products": [ "species_111627", "species_188972" ], "modifiers": [ [ "species_10629103", "catalyst" ] ], "additional_components": [ "Q58QG8", "WBGene00019844" ] }, "reaction_10660894": { "compartment": "compartment_70101", "id": "reaction_10660894", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660850" ], "products": [ "species_10660892" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10660852": { "compartment": "compartment_70101", "id": "reaction_10660852", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10660848" ], "products": [ "species_10660850" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10661709": { "compartment": "compartment_7660", "id": "reaction_10661709", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658641", "species_10635479" ], "products": [ "species_10661707" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748" ] }, "reaction_10661669": { "compartment": "compartment_7660", "id": "reaction_10661669", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639320", "species_10658641" ], "products": [ "species_10661667" ], "modifiers": [], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00004393", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393", "Q10666", "WBGene00004077" ] }, "reaction_10624784": { "compartment": "compartment_20699", "id": "reaction_10624784", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_744233", "species_113578" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10624776": { "compartment": "compartment_20699", "id": "reaction_10624776", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624779": { "compartment": "compartment_20699", "id": "reaction_10624779", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624768": { "compartment": "compartment_20699", "id": "reaction_10624768", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10624765", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10624732": { "compartment": "compartment_20699", "id": "reaction_10624732", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_109395", "species_727815" ], "modifiers": [ [ "species_10624729", "catalyst" ] ], "additional_components": [ "Q95X47", "WBGene00015038", "Q93890", "WBGene00005153", "O17106", "WBGene00019451", "G5EBK5", "WBGene00018414", "O01879", "WBGene00022577", "O02345", "WBGene00014139" ] }, "reaction_10624786": { "compartment": "compartment_20699", "id": "reaction_10624786", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_744229" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "species_914003", "species_29410", "species_914003", "species_29410", "WBGene00005025" ] }, "reaction_10624737": { "compartment": "compartment_20699", "id": "reaction_10624737", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10624734", "catalyst" ] ], "additional_components": [ "species_1981137", "species_735700", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10624760": { "compartment": "compartment_20699", "id": "reaction_10624760", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_109402", "species_914003" ], "modifiers": [ [ "species_10624757", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10604090": { "compartment": "compartment_7660", "id": "reaction_10604090", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10604083" ], "products": [ "species_10604087", "species_76230" ], "modifiers": [ [ "species_10604081", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604085": { "compartment": "compartment_7660", "id": "reaction_10604085", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10604081" ], "products": [ "species_10604083" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604745": { "compartment": "compartment_7660", "id": "reaction_10604745", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604079" ], "products": [ "species_10604081" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604520": { "compartment": "compartment_70101", "id": "reaction_10604520", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604487" ], "products": [ "species_29370", "species_10604517" ], "modifiers": [ [ "species_10604487", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10604524": { "compartment": "compartment_70101", "id": "reaction_10604524", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604517" ], "products": [ "species_10604483", "species_10604515" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10604489": { "compartment": "compartment_70101", "id": "reaction_10604489", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604483", "species_10604485" ], "products": [ "species_10604487" ], "modifiers": [], "additional_components": [ "WBGene00003186", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10599814": { "compartment": "compartment_70101", "id": "reaction_10599814", "reactome": "R-CEL-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10599811", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10622380": { "compartment": "compartment_5460", "id": "reaction_10622380", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10622377", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10666164": { "compartment": "compartment_876", "id": "reaction_10666164", "reactome": "R-CEL-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666158" ], "products": [ "species_10666162" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10646545": { "compartment": "compartment_876", "id": "reaction_10646545", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10608724" ], "products": [ "species_10646543" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "O62422", "WBGene00012532" ] }, "reaction_10640507": { "compartment": "compartment_70101", "id": "reaction_10640507", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640503", "species_10640499" ], "products": [ "species_10640505" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_109496", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "D6VPA1", "WBGene00018976", "Q22038", "WBGene00004357", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438", "species_109496" ] }, "reaction_10663659": { "compartment": "compartment_876", "id": "reaction_10663659", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663655", "species_10605408" ], "products": [ "species_10663657" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10665864": { "compartment": "compartment_17906", "id": "reaction_10665864", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665860", "species_10665854" ], "products": [ "species_10665862" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q19848", "WBGene00017895", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "G5EFU0", "WBGene00006443", "species_29438", "Q19848", "WBGene00017895" ] }, "reaction_10665798": { "compartment": "compartment_876", "id": "reaction_10665798", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724" ], "products": [ "species_10665796" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10665839": { "compartment": "compartment_876", "id": "reaction_10665839", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665835", "species_10665808" ], "products": [ "species_10665837" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064" ] }, "reaction_10665924": { "compartment": "compartment_876", "id": "reaction_10665924", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10665808" ], "products": [ "species_29372", "species_10665806" ], "modifiers": [ [ "species_10665921", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "P34288", "WBGene00015418", "Q19370", "WBGene00006406", "Q21341", "WBGene00002368", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10663798": { "compartment": "compartment_876", "id": "reaction_10663798", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10635280" ], "products": [ "species_10663796" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356" ] }, "reaction_10646773": { "compartment": "compartment_70101", "id": "reaction_10646773", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646765" ], "products": [ "species_29370", "species_10646770" ], "modifiers": [ [ "species_10618297", "catalyst" ] ], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00003911" ] }, "reaction_10663794": { "compartment": "compartment_876", "id": "reaction_10663794", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663790", "species_10605399" ], "products": [ "species_10663792" ], "modifiers": [], "additional_components": [ "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532", "Q03206", "ced-10", "species_29438", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "species_29438", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532" ] }, "reaction_10665790": { "compartment": "compartment_876", "id": "reaction_10665790", "reactome": "R-CEL-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828" ], "products": [ "species_10646655" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646685": { "compartment": "compartment_70101", "id": "reaction_10646685", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070", "species_10646679" ], "products": [ "species_10646683" ], "modifiers": [], "additional_components": [ "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438", "G5EE56", "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645649": { "compartment": "compartment_876", "id": "reaction_10645649", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10612107" ], "products": [ "species_10645644" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10645640": { "compartment": "compartment_70101", "id": "reaction_10645640", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645636", "species_10617721" ], "products": [ "species_10645638" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10636358": { "compartment": "compartment_70101", "id": "reaction_10636358", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635378" ], "products": [ "species_10635374", "species_10635408" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "species_179838", "species_29438", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q05062", "WBGene00000390", "Q10929", "WBGene00015146", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "species_179856", "O62422", "WBGene00012532", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10663835": { "compartment": "compartment_876", "id": "reaction_10663835", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663829", "species_10663831" ], "products": [ "species_10663833" ], "modifiers": [], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "species_29420", "Q05062", "WBGene00000390", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "O62422", "WBGene00012532" ] }, "reaction_10663622": { "compartment": "compartment_876", "id": "reaction_10663622", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10645591": { "compartment": "compartment_7660", "id": "reaction_10645591", "reactome": "R-CEL-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645574", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10645588" ], "modifiers": [ [ "species_10645574", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10663868": { "compartment": "compartment_876", "id": "reaction_10663868", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10663860" ], "products": [ "species_29372", "species_10663856" ], "modifiers": [ [ "species_10663865", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "P34288", "WBGene00015418", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10635410": { "compartment": "compartment_70101", "id": "reaction_10635410", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10635408" ], "products": [ "species_10633825" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "species_113592", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10635825": { "compartment": "compartment_876", "id": "reaction_10635825", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635822" ], "products": [ "species_29370", "species_10635372" ], "modifiers": [ [ "species_10616051", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "WBGene00000018" ] }, "reaction_10665794": { "compartment": "compartment_876", "id": "reaction_10665794", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399" ], "products": [ "species_10665792" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438" ] }, "reaction_10663685": { "compartment": "compartment_70101", "id": "reaction_10663685", "reactome": "R-CEL-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663681", "species_10646828" ], "products": [ "species_10663683" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "P92199", "WBGene00002694", "Q93332", "WBGene00007954", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "O02495", "WBGene00004897", "A0A4V0IKG6", "WBGene00007287", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q09994", "WBGene00019608", "Q17777", "WBGene00007409", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646783": { "compartment": "compartment_70101", "id": "reaction_10646783", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618297", "species_10646779" ], "products": [ "species_10646781" ], "modifiers": [], "additional_components": [ "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10646707": { "compartment": "compartment_70101", "id": "reaction_10646707", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10646703" ], "products": [ "species_10646705" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00016678", "Q22038", "WBGene00004357", "Q09506", "WBGene00016678", "Q17777", "WBGene00007409", "species_29438" ] }, "reaction_10663135": { "compartment": "compartment_70101", "id": "reaction_10663135", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617736", "species_10617721" ], "products": [ "species_10617734", "species_10645758" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10646791": { "compartment": "compartment_70101", "id": "reaction_10646791", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646781" ], "products": [ "species_29370", "species_10618297", "species_10646788" ], "modifiers": [ [ "species_10646781", "catalyst" ] ], "additional_components": [ "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10663863": { "compartment": "compartment_876", "id": "reaction_10663863", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663856" ], "products": [ "species_29420", "species_10663860" ], "modifiers": [ [ "species_10663856", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10663687": { "compartment": "compartment_70101", "id": "reaction_10663687", "reactome": "R-CEL-9013108", "name": "GDIs block activation of RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10646812": { "compartment": "compartment_70101", "id": "reaction_10646812", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646765", "species_10646805" ], "products": [ "species_10646810" ], "modifiers": [], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00010109", "Q7YX00", "WBGene00010109", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10663965": { "compartment": "compartment_876", "id": "reaction_10663965", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663957" ], "products": [ "species_10663959" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10664030": { "compartment": "compartment_876", "id": "reaction_10664030", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664027" ], "products": [ "species_10664007", "species_29420" ], "modifiers": [ [ "species_10664027", "catalyst" ] ], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10665788": { "compartment": "compartment_74700", "id": "reaction_10665788", "reactome": "R-CEL-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10665784" ], "products": [ "species_10665786" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10664025": { "compartment": "compartment_876", "id": "reaction_10664025", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664007", "species_10664021" ], "products": [ "species_10664023" ], "modifiers": [], "additional_components": [ "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10646777": { "compartment": "compartment_70101", "id": "reaction_10646777", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10635289" ], "products": [ "species_10646775" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "WBGene00003593", "H2KYX3", "WBGene00003593", "Q17850", "WBGene00003911" ] }, "reaction_10645608": { "compartment": "compartment_7660", "id": "reaction_10645608", "reactome": "R-CEL-5625870", "name": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10645588" ], "products": [ "species_159942", "species_159939", "species_10645605", "species_29478", "species_10628328" ], "modifiers": [ [ "species_10645588", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10665811": { "compartment": "compartment_876", "id": "reaction_10665811", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665806" ], "products": [ "species_10665808", "species_29420" ], "modifiers": [ [ "species_10665806", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10663849": { "compartment": "compartment_876", "id": "reaction_10663849", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724", "species_29356" ], "products": [ "species_10663829", "species_29372" ], "modifiers": [ [ "species_10663846", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10645560": { "compartment": "compartment_7660", "id": "reaction_10645560", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10645540" ], "products": [ "species_113582", "species_10645557" ], "modifiers": [ [ "species_10645540", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10651401": { "compartment": "compartment_1222693", "id": "reaction_10651401", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10651398", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10663703": { "compartment": "compartment_876", "id": "reaction_10663703", "reactome": "R-CEL-9013111", "name": "RHOC GAPs stimulate RHOC GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663700", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q9XUS9", "WBGene00000875", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10664051": { "compartment": "compartment_876", "id": "reaction_10664051", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664049" ], "products": [ "species_10664034", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059" ] }, "reaction_10646846": { "compartment": "compartment_876", "id": "reaction_10646846", "reactome": "R-CEL-5671993", "name": "CIT-3 binds DLG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10646842" ], "products": [ "species_10646844" ], "modifiers": [], "additional_components": [ "WBGene00001006", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "G5ECY0", "WBGene00001006" ] }, "reaction_10663131": { "compartment": "compartment_70101", "id": "reaction_10663131", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663128", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "O01443", "WBGene00015303", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "A0A0K3AW57", "Y75B7AL.4c", "Q23130", "WBGene00012203" ] }, "reaction_10635383": { "compartment": "compartment_70101", "id": "reaction_10635383", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635372" ], "products": [ "species_29370", "species_10635358" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10663692": { "compartment": "compartment_70101", "id": "reaction_10663692", "reactome": "R-CEL-9013109", "name": "RHOC GEFs activate RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10663689", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10636374": { "compartment": "compartment_70101", "id": "reaction_10636374", "reactome": "R-CEL-2197698", "name": "Src phosphorylate WASP,N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636371", "species_113592" ], "products": [ "species_29370", "species_10635306" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "WBGene00002213" ] }, "reaction_10646698": { "compartment": "compartment_876", "id": "reaction_10646698", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10617024" ], "products": [ "species_10646696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00002996", "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "A5PEX5", "WBGene00002996" ] }, "reaction_10645075": { "compartment": "compartment_876", "id": "reaction_10645075", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645069", "species_10604443" ], "products": [ "species_10645073" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663754": { "compartment": "compartment_876", "id": "reaction_10663754", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399", "species_29356" ], "products": [ "species_10635280", "species_29372" ], "modifiers": [ [ "species_10663751", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "species_29420", "Q03206", "ced-10", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q86NH1", "WBGene00006363", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10665856": { "compartment": "compartment_876", "id": "reaction_10665856", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665854" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646651": { "compartment": "compartment_70101", "id": "reaction_10646651", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10646643" ], "products": [ "species_10646645" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10666148": { "compartment": "compartment_876", "id": "reaction_10666148", "reactome": "R-CEL-9714363", "name": "RHOC translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663963": { "compartment": "compartment_876", "id": "reaction_10663963", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10663959" ], "products": [ "species_10663961" ], "modifiers": [], "additional_components": [ "WBGene00004356", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q20496", "WBGene00004356", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10663669": { "compartment": "compartment_70101", "id": "reaction_10663669", "reactome": "R-CEL-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663663", "species_10663661" ], "products": [ "species_10663667" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664047": { "compartment": "compartment_876", "id": "reaction_10664047", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664043", "species_10664034" ], "products": [ "species_10664045" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "Q8I4M6", "WBGene00007840", "O17772", "WBGene00003980", "Q95PX0", "WBGene00006410", "Q21341", "WBGene00002368", "G5EFU0", "WBGene00006443", "Q17850", "WBGene00003911", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "G5EDP9", "WBGene00000001", "Q21408", "WBGene00004951", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "Q9NAN2", "WBGene00003921", "G5EES9", "WBGene00021826", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "G5EES9", "WBGene00021826", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10635380": { "compartment": "compartment_70101", "id": "reaction_10635380", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635376", "species_10620766" ], "products": [ "species_10635378" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "species_113592", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10646757": { "compartment": "compartment_70101", "id": "reaction_10646757", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646734" ], "products": [ "species_29370", "species_10646754" ], "modifiers": [ [ "species_10618307", "catalyst" ] ], "additional_components": [ "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10640501": { "compartment": "compartment_70101", "id": "reaction_10640501", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640497" ], "products": [ "species_10640499" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00018976", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10646808": { "compartment": "compartment_70101", "id": "reaction_10646808", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646802" ], "products": [ "species_29370", "species_10646805" ], "modifiers": [ [ "species_10645086", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10662944": { "compartment": "compartment_70101", "id": "reaction_10662944", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10662941", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "H2L0P5", "WBGene00022391", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476" ] }, "reaction_10635291": { "compartment": "compartment_70101", "id": "reaction_10635291", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10617721" ], "products": [ "species_10635282", "species_10617723" ], "modifiers": [ [ "species_10635289", "inhibitor" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "WBGene00003593" ] }, "reaction_10646561": { "compartment": "compartment_70101", "id": "reaction_10646561", "reactome": "R-CEL-5665761", "name": "FMNL3 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646557", "species_10605408" ], "products": [ "species_10646559" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10665870": { "compartment": "compartment_876", "id": "reaction_10665870", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665868" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663881": { "compartment": "compartment_876", "id": "reaction_10663881", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10663877" ], "products": [ "species_10663879" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "Q22038", "WBGene00004357", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "species_29438" ] }, "reaction_10663710": { "compartment": "compartment_876", "id": "reaction_10663710", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10663707", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "A0A0K3AR51", "F22G12.5c" ] }, "reaction_10646681": { "compartment": "compartment_70101", "id": "reaction_10646681", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10646673" ], "products": [ "species_10646679" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645071": { "compartment": "compartment_876", "id": "reaction_10645071", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645059", "species_10645067" ], "products": [ "species_10645069" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10645765": { "compartment": "compartment_70101", "id": "reaction_10645765", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645762", "species_113592" ], "products": [ "species_29370", "species_10618313", "species_10617721" ], "modifiers": [ [ "species_10645762", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10663883": { "compartment": "compartment_876", "id": "reaction_10663883", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10646677" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663698": { "compartment": "compartment_876", "id": "reaction_10663698", "reactome": "R-CEL-9013110", "name": "RHOC binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10663694" ], "products": [ "species_10663696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646549": { "compartment": "compartment_876", "id": "reaction_10646549", "reactome": "R-CEL-5665748", "name": "FMNL2 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10605408" ], "products": [ "species_10646547" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10646669": { "compartment": "compartment_70101", "id": "reaction_10646669", "reactome": "R-CEL-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10646665" ], "products": [ "species_10646667" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645646": { "compartment": "compartment_70101", "id": "reaction_10645646", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10620766" ], "products": [ "species_10645642" ], "modifiers": [ [ "species_10645644", "inhibitor" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "species_113592", "P10984", "WBGene00000064", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_113592", "species_29438", "P10984", "WBGene00000064", "O62422", "WBGene00012532", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10665850": { "compartment": "compartment_70101", "id": "reaction_10665850", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665846", "species_10663860" ], "products": [ "species_10665848" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "B3WFV9", "WBGene00009920", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203" ] }, "reaction_10645755": { "compartment": "compartment_13949", "id": "reaction_10645755", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645739" ], "products": [ "species_10645753" ], "modifiers": [ [ "species_10645739", "catalyst" ] ], "additional_components": [ "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10663674": { "compartment": "compartment_70101", "id": "reaction_10663674", "reactome": "R-CEL-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828", "species_29356" ], "products": [ "species_10663661", "species_29372" ], "modifiers": [ [ "species_10663671", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10663133": { "compartment": "compartment_70101", "id": "reaction_10663133", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617740", "species_10617721" ], "products": [ "species_10645760", "species_10617738" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10665919": { "compartment": "compartment_20699", "id": "reaction_10665919", "reactome": "R-CEL-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665915", "species_10665868" ], "products": [ "species_10665917" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017" ] }, "reaction_10645095": { "compartment": "compartment_70101", "id": "reaction_10645095", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645073" ], "products": [ "species_29370", "species_10645067", "species_10604443", "species_10645086" ], "modifiers": [ [ "species_10645073", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663842": { "compartment": "compartment_876", "id": "reaction_10663842", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663829" ], "products": [ "species_10608724", "species_29420" ], "modifiers": [ [ "species_10663839", "catalyst" ] ], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "G5ECK4", "WBGene00044989", "Q19572", "WBGene00001674", "O17905", "WBGene00001490", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "A0A0K3AR51", "F22G12.5c", "X5LV34", "WBGene00001366", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10663679": { "compartment": "compartment_876", "id": "reaction_10663679", "reactome": "R-CEL-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663661" ], "products": [ "species_10646828", "species_29420" ], "modifiers": [ [ "species_10663676", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10663618": { "compartment": "compartment_70101", "id": "reaction_10663618", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664000": { "compartment": "compartment_876", "id": "reaction_10664000", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663996", "species_10663959" ], "products": [ "species_10663998" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q94124", "WBGene00004287", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "Q03206", "ced-10", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "species_29438", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q9BL44", "WBGene00022177", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064" ] }, "reaction_10666146": { "compartment": "compartment_12045", "id": "reaction_10666146", "reactome": "R-CEL-9714361", "name": "RHOC activates endoplasmic reticulum effectors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666142", "species_10663620" ], "products": [ "species_10666144" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066" ] }, "reaction_10645593": { "compartment": "compartment_7660", "id": "reaction_10645593", "reactome": "R-CEL-5625849", "name": "Demethylase KDM1A binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645572", "species_10628328" ], "products": [ "species_10645574" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10646582": { "compartment": "compartment_876", "id": "reaction_10646582", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646573", "species_10646578" ], "products": [ "species_10646580" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698", "WBGene00006406", "Q03206", "ced-10", "Q19370", "WBGene00006406", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698" ] }, "reaction_10650007": { "compartment": "compartment_70101", "id": "reaction_10650007", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628563" ], "products": [ "species_10628579" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663391": { "compartment": "compartment_70101", "id": "reaction_10663391", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663357" ], "products": [ "species_10663389" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663332": { "compartment": "compartment_70101", "id": "reaction_10663332", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663320" ], "products": [ "species_10663330" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625371": { "compartment": "compartment_70101", "id": "reaction_10625371", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613343", "species_10625343" ], "products": [ "species_10625369" ], "modifiers": [], "additional_components": [ "WBGene00006887", "WBGene00004829", "Q19019", "WBGene00004829", "Q45FX5", "WBGene00006887" ] }, "reaction_10663909": { "compartment": "compartment_984", "id": "reaction_10663909", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622329", "species_10663905" ], "products": [ "species_10663907" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q22666", "WBGene00011917" ] }, "reaction_10625148": { "compartment": "compartment_70101", "id": "reaction_10625148", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623793", "species_10625144", "species_10608624", "species_10602400" ], "products": [ "species_10625146" ], "modifiers": [], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q18462", "WBGene00016416", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10650185": { "compartment": "compartment_70101", "id": "reaction_10650185", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650179" ], "products": [ "species_10650183" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625379": { "compartment": "compartment_70101", "id": "reaction_10625379", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617312", "species_10625343" ], "products": [ "species_10625373" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10625367": { "compartment": "compartment_70101", "id": "reaction_10625367", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625350", "species_10625345" ], "products": [ "species_10625365" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10622343": { "compartment": "compartment_984", "id": "reaction_10622343", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10622329" ], "products": [ "species_10622331" ], "modifiers": [ [ "species_10622341", "inhibitor" ] ], "additional_components": [ "WBGene00006798", "WBGene00011917", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O44412", "WBGene00020298", "A5PEW5", "WBGene00004364", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10663421": { "compartment": "compartment_984", "id": "reaction_10663421", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10663322": { "compartment": "compartment_70101", "id": "reaction_10663322", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310", "species_10663269" ], "products": [ "species_10663320" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650009": { "compartment": "compartment_70101", "id": "reaction_10650009", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559" ], "products": [ "species_10628563" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650236": { "compartment": "compartment_70101", "id": "reaction_10650236", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650183" ], "products": [ "species_10650234" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663381": { "compartment": "compartment_70101", "id": "reaction_10663381", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663365" ], "products": [ "species_10663367" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663314": { "compartment": "compartment_70101", "id": "reaction_10663314", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310" ], "products": [ "species_10663312" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663482": { "compartment": "compartment_70101", "id": "reaction_10663482", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617052" ], "products": [ "species_29370", "species_10663269" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650353": { "compartment": "compartment_70101", "id": "reaction_10650353", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650347" ], "products": [ "species_10650351" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663318": { "compartment": "compartment_70101", "id": "reaction_10663318", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263" ], "products": [ "species_10663316" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663377": { "compartment": "compartment_70101", "id": "reaction_10663377", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663367" ], "products": [ "species_10663375" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663359": { "compartment": "compartment_70101", "id": "reaction_10663359", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661639" ], "products": [ "species_10663357" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650349": { "compartment": "compartment_70101", "id": "reaction_10650349", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650345" ], "products": [ "species_10650347" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628569": { "compartment": "compartment_70101", "id": "reaction_10628569", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628561" ], "products": [ "species_10628567" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628583": { "compartment": "compartment_70101", "id": "reaction_10628583", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628567" ], "products": [ "species_10628581" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10622841": { "compartment": "compartment_70101", "id": "reaction_10622841", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622832" ], "products": [ "species_10622838" ], "modifiers": [ [ "species_10622832", "catalyst" ] ], "additional_components": [ "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727" ] }, "reaction_10625377": { "compartment": "compartment_70101", "id": "reaction_10625377", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625373", "species_10607816" ], "products": [ "species_10625375" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238", "WBGene00021320", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10650548": { "compartment": "compartment_17957", "id": "reaction_10650548", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10650546" ], "modifiers": [ [ "species_10628579", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10636285": { "compartment": "compartment_7660", "id": "reaction_10636285", "reactome": "R-CEL-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636283" ], "products": [], "modifiers": [], "additional_components": [ "G5EDM7", "WBGene00000901", "P0CG71", "WBGene00006727" ] }, "reaction_10607909": { "compartment": "compartment_7660", "id": "reaction_10607909", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10636243": { "compartment": "compartment_7660", "id": "reaction_10636243", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636237", "species_10597874" ], "products": [ "species_10636235", "species_10636241" ], "modifiers": [], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00006727", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636145": { "compartment": "compartment_876", "id": "reaction_10636145", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636143" ], "products": [], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "G5EDS9", "WBGene00006445", "P20792", "WBGene00000897", "P0CG71", "WBGene00006727" ] }, "reaction_10636343": { "compartment": "compartment_70101", "id": "reaction_10636343", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636336" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727" ] }, "reaction_10635812": { "compartment": "compartment_7660", "id": "reaction_10635812", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873", "species_10635808" ], "products": [ "species_10635810" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "Q21733", "WBGene00000904", "G5EDT1", "WBGene00003020", "F5GUE5", "WBGene00000910", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "P45897", "WBGene00004858", "G5EF11", "WBGene00001161" ] }, "reaction_10635466": { "compartment": "compartment_70101", "id": "reaction_10635466", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10607745" ], "products": [ "species_10635464" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10607715" ], "products": [ "species_10607745" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10642987": { "compartment": "compartment_13231", "id": "reaction_10642987", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642983", "species_10600633" ], "products": [ "species_10642985" ], "modifiers": [], "additional_components": [ "WBGene00010117", "WBGene00004806", "Q9XUY5", "WBGene00010117", "Q22836", "WBGene00004806" ] }, "reaction_10641008": { "compartment": "compartment_876", "id": "reaction_10641008", "reactome": "R-CEL-4332235", "name": "CBL binds TGFBR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607752", "species_10608624" ], "products": [ "species_10641006" ], "modifiers": [], "additional_components": [ "WBGene00000900", "WBGene00004829", "P50488", "WBGene00000900", "Q19019", "WBGene00004829" ] }, "reaction_10636347": { "compartment": "compartment_70101", "id": "reaction_10636347", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613620" ], "products": [ "species_10607792" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636330": { "compartment": "compartment_7660", "id": "reaction_10636330", "reactome": "R-CEL-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10636312" ], "products": [ "species_10636327", "species_427497", "species_10636310" ], "modifiers": [ [ "species_10636312", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10625009": { "compartment": "compartment_7660", "id": "reaction_10625009", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625005" ], "products": [ "species_10625007" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636339": { "compartment": "compartment_70101", "id": "reaction_10636339", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636334", "species_10597908" ], "products": [ "species_10627446", "species_10636336" ], "modifiers": [ [ "species_10636334", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500", "WBGene00006727", "WBGene00000500", "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10607797": { "compartment": "compartment_171062", "id": "reaction_10607797", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607794", "species_113592" ], "products": [ "species_29370", "species_10607778" ], "modifiers": [ [ "species_10607794", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636345": { "compartment": "compartment_7660", "id": "reaction_10636345", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613608", "species_10607873" ], "products": [ "species_10613610" ], "modifiers": [], "additional_components": [ "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636356": { "compartment": "compartment_70101", "id": "reaction_10636356", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10636349" ], "products": [ "species_10636351" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636305": { "compartment": "compartment_7660", "id": "reaction_10636305", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636301", "species_10607873" ], "products": [ "species_10636303" ], "modifiers": [], "additional_components": [ "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636332": { "compartment": "compartment_7660", "id": "reaction_10636332", "reactome": "R-CEL-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636310", "species_10607873" ], "products": [ "species_10636312" ], "modifiers": [], "additional_components": [ "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10607782": { "compartment": "compartment_17941", "id": "reaction_10607782", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607778" ], "products": [ "species_10607737", "species_10607780" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636289": { "compartment": "compartment_7660", "id": "reaction_10636289", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636287" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P0CG71", "WBGene00006727" ] }, "reaction_10607888": { "compartment": "compartment_70101", "id": "reaction_10607888", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607873" ], "modifiers": [ [ "species_10607886", "inhibitor" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10635770": { "compartment": "compartment_70101", "id": "reaction_10635770", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635464" ], "products": [ "species_10635768" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10636354": { "compartment": "compartment_70101", "id": "reaction_10636354", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636351", "species_29356" ], "products": [ "species_10636349", "species_10607792", "species_29372" ], "modifiers": [ [ "species_10636351", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636207": { "compartment": "compartment_70101", "id": "reaction_10636207", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636205" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P0CG71", "WBGene00006727" ] }, "reaction_10636239": { "compartment": "compartment_7660", "id": "reaction_10636239", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636226", "species_10636235" ], "products": [ "species_10636237" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636341": { "compartment": "compartment_70101", "id": "reaction_10636341", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627446", "species_10607790" ], "products": [ "species_10636334" ], "modifiers": [], "additional_components": [ "WBGene00000500", "WBGene00000904", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10636233": { "compartment": "compartment_7660", "id": "reaction_10636233", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607873" ], "products": [ "species_113582", "species_10636226" ], "modifiers": [ [ "species_10636230", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "O17869", "WBGene00009650", "Q9TYP2", "WBGene00000506", "P34425", "WBGene00000507", "P90866", "WBGene00000409", "Q9TVL3", "WBGene00000410" ] }, "reaction_10613623": { "compartment": "compartment_7660", "id": "reaction_10613623", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10613610" ], "products": [ "species_10613620", "species_113550", "species_10607859", "species_10613608" ], "modifiers": [ [ "species_10613610", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636245": { "compartment": "compartment_7660", "id": "reaction_10636245", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636241" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10640756": { "compartment": "compartment_876", "id": "reaction_10640756", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640622", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640625": { "compartment": "compartment_876", "id": "reaction_10640625", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640620" ], "products": [ "species_29370", "species_10640622" ], "modifiers": [ [ "species_10640620", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640831": { "compartment": "compartment_876", "id": "reaction_10640831", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640828", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "O01847", "WBGene00015704", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q19475", "WBGene00001164" ] }, "reaction_10633379": { "compartment": "compartment_161320", "id": "reaction_10633379", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10635744": { "compartment": "compartment_20699", "id": "reaction_10635744", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635741", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q9TZK5", "WBGene00002030", "Q4TTA0", "WBGene00044303" ] }, "reaction_10634068": { "compartment": "compartment_20699", "id": "reaction_10634068", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10633892" ], "products": [ "species_205687", "species_10634052" ], "modifiers": [ [ "species_10634065", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005021" ] }, "reaction_10634930": { "compartment": "compartment_876", "id": "reaction_10634930", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633349" ], "products": [ "species_10633006" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10635710": { "compartment": "compartment_17963", "id": "reaction_10635710", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635705", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10632896": { "compartment": "compartment_161320", "id": "reaction_10632896", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10634893": { "compartment": "compartment_20699", "id": "reaction_10634893", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634851", "species_741440" ], "products": [ "species_10634879", "species_742343" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10635730": { "compartment": "compartment_20699", "id": "reaction_10635730", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10634958" ], "products": [ "species_10634986", "species_742343" ], "modifiers": [ [ "species_10635727", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002029" ] }, "reaction_10635764": { "compartment": "compartment_161320", "id": "reaction_10635764", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10632794": { "compartment": "compartment_161320", "id": "reaction_10632794", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10634060": { "compartment": "compartment_20699", "id": "reaction_10634060", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10634052" ], "products": [ "species_10633930", "species_205687" ], "modifiers": [ [ "species_10634057", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005020" ] }, "reaction_10633424": { "compartment": "compartment_161320", "id": "reaction_10633424", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065212", "species_1605715" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10633421", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10665103": { "compartment": "compartment_20699", "id": "reaction_10665103", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634019", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q09363", "WBGene00005026", "species_266099" ] }, "reaction_10634024": { "compartment": "compartment_20699", "id": "reaction_10634024", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634021", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "O62113", "WBGene00008160", "Q9XU73", "WBGene00011781", "O02304", "WBGene00011650", "O17708", "WBGene00008293", "Q09363", "WBGene00005026", "A0A0K3AUF6", "W07G9.2b", "species_266099", "O17751", "WBGene00008479" ] }, "reaction_10633902": { "compartment": "compartment_20699", "id": "reaction_10633902", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10633864" ], "products": [ "species_10633892", "species_205687" ], "modifiers": [ [ "species_10633897", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005024" ] }, "reaction_10665106": { "compartment": "compartment_161320", "id": "reaction_10665106", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10635766": { "compartment": "compartment_161320", "id": "reaction_10635766", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636009": { "compartment": "compartment_876", "id": "reaction_10636009", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10635722": { "compartment": "compartment_20699", "id": "reaction_10635722", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635042", "species_741440" ], "products": [ "species_742343", "species_10635064" ], "modifiers": [ [ "species_10635715", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002031" ] }, "reaction_10635180": { "compartment": "compartment_17963", "id": "reaction_10635180", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635066" ], "products": [ "species_10635178" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10665110": { "compartment": "compartment_161320", "id": "reaction_10665110", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10633440": { "compartment": "compartment_161320", "id": "reaction_10633440", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "CHEBI:63513", "CHEBI:63511", "CHEBI:63512", "CHEBI:63515", "WBGene00011923" ] }, "reaction_10635762": { "compartment": "compartment_161320", "id": "reaction_10635762", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10634924": { "compartment": "compartment_20699", "id": "reaction_10634924", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634921", "species_2022884" ], "products": [ "species_10634851", "species_2022890" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10646062": { "compartment": "compartment_7660", "id": "reaction_10646062", "reactome": "R-CEL-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10646052" ], "products": [ "species_10646054", "species_5651834" ], "modifiers": [ [ "species_10646059", "catalyst" ] ], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "WBGene00004051" ] }, "reaction_10606556": { "compartment": "compartment_5460", "id": "reaction_10606556", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10606552" ], "products": [ "species_10606554" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10606439": { "compartment": "compartment_70101", "id": "reaction_10606439", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10606436", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10604420": { "compartment": "compartment_70101", "id": "reaction_10604420", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10604417", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "E6N0V1", "WBGene00018819", "Q10656", "WBGene00001184", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10604454": { "compartment": "compartment_70101", "id": "reaction_10604454", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604434" ], "products": [ "species_29370", "species_10604451" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "species_179838", "Q17941", "WBGene00000102", "species_179838", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604445": { "compartment": "compartment_876", "id": "reaction_10604445", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604441" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604436": { "compartment": "compartment_876", "id": "reaction_10604436", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604432" ], "products": [ "species_10604434", "species_10604425" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "G5EED4", "WBGene00010700", "species_179838", "Q17941", "WBGene00000102", "WBGene00010700" ] }, "reaction_10610560": { "compartment": "compartment_876", "id": "reaction_10610560", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605406" ], "products": [ "species_10605408" ], "modifiers": [ [ "species_10610557", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10619825": { "compartment": "compartment_7660", "id": "reaction_10619825", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619821", "species_10619819" ], "products": [ "species_10619823" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00023409", "Q27894", "WBGene00001878", "G5ECR1", "WBGene00023409", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619863": { "compartment": "compartment_7660", "id": "reaction_10619863", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_77087" ], "products": [ "species_10602565", "species_77502" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619860": { "compartment": "compartment_7660", "id": "reaction_10619860", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10619843" ], "products": [ "species_10614288", "species_427498", "species_427497" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10641870": { "compartment": "compartment_7660", "id": "reaction_10641870", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641868" ], "products": [ "species_10641841", "species_10641860", "species_10641866" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642922": { "compartment": "compartment_7660", "id": "reaction_10642922", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10642887" ], "products": [ "species_113550", "species_10642907", "species_10642885" ], "modifiers": [ [ "species_10642919", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "WBGene00018328", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641839": { "compartment": "compartment_7660", "id": "reaction_10641839", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641817" ], "modifiers": [ [ "species_10641836", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10641843": { "compartment": "compartment_7660", "id": "reaction_10641843", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641841" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639827": { "compartment": "compartment_70101", "id": "reaction_10639827", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639821" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10642845": { "compartment": "compartment_70101", "id": "reaction_10642845", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642788", "species_10642841" ], "products": [ "species_10642843" ], "modifiers": [], "additional_components": [ "WBGene00018328", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250" ] }, "reaction_10641858": { "compartment": "compartment_7660", "id": "reaction_10641858", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641822" ], "modifiers": [ [ "species_10641855", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583" ] }, "reaction_10639846": { "compartment": "compartment_7660", "id": "reaction_10639846", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10639841" ], "products": [ "species_113582", "species_10639835" ], "modifiers": [ [ "species_10639843", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000227" ] }, "reaction_10643043": { "compartment": "compartment_70101", "id": "reaction_10643043", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10643038" ], "products": [ "species_10639783", "species_10614711", "species_10643040", "species_10639865" ], "modifiers": [ [ "species_10643038", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q9U266", "WBGene00001838", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838" ] }, "reaction_10639788": { "compartment": "compartment_70101", "id": "reaction_10639788", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639786" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10639869": { "compartment": "compartment_70101", "id": "reaction_10639869", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639867" ], "products": [ "species_10639783", "species_10614711", "species_10639865" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642951": { "compartment": "compartment_70101", "id": "reaction_10642951", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642841", "species_29356" ], "products": [ "species_10642942", "species_29372" ], "modifiers": [ [ "species_10642948", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641824": { "compartment": "compartment_7660", "id": "reaction_10641824", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641729" ], "products": [ "species_10641812" ], "modifiers": [ [ "species_10641822", "catalyst" ], [ "species_10641817", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EC99", "WBGene00008714", "G5EE36", "WBGene00002013", "Q9U3B7", "WBGene00002002", "Q20363", "WBGene00004798", "G5EE65", "WBGene00011906", "P34696", "WBGene00002015", "Q17849", "WBGene00002023", "G5EF99", "WBGene00014233", "B0M0L8", "WBGene00002024", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "Q19227", "WBGene00014233", "P02513", "WBGene00002019", "P06581", "WBGene00002018", "P06582", "WBGene00002016", "Q20660", "WBGene00002021", "Q20164", "WBGene00002012", "P34328", "WBGene00002011", "Q19228", "WBGene00014233", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639832": { "compartment": "compartment_70101", "id": "reaction_10639832", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639830" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10641668": { "compartment": "compartment_70101", "id": "reaction_10641668", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10641665" ], "modifiers": [ [ "species_10609552", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10639859": { "compartment": "compartment_7660", "id": "reaction_10639859", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_10639855" ], "products": [ "species_10639857" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10639877": { "compartment": "compartment_70101", "id": "reaction_10639877", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783" ], "products": [ "species_10639821" ], "modifiers": [ [ "species_10605919", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10642990": { "compartment": "compartment_70101", "id": "reaction_10642990", "reactome": "R-CEL-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642843" ], "products": [ "species_10642887" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10643016": { "compartment": "compartment_70101", "id": "reaction_10643016", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642942", "species_113592" ], "products": [ "species_29370", "species_10642841" ], "modifiers": [ [ "species_10643006", "catalyst" ], [ "species_10643014", "inhibitor" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "O61980", "WBGene00006760", "O44739", "WBGene00000236", "Q05036", "WBGene00016250", "G5EE04", "WBGene00011735" ] }, "reaction_10639839": { "compartment": "compartment_7660", "id": "reaction_10639839", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639835", "species_10619855" ], "products": [ "species_10639837" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10631172": { "compartment": "compartment_70616", "id": "reaction_10631172", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10631169", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10640468": { "compartment": "compartment_984", "id": "reaction_10640468", "reactome": "R-CEL-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10640457", "species_10640455" ], "modifiers": [ [ "species_10640465", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q9BL26", "WBGene00044760", "Q20176", "WBGene00003555" ] }, "reaction_10632241": { "compartment": "compartment_876", "id": "reaction_10632241", "reactome": "R-CEL-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237", "species_10631688" ], "products": [ "species_10632239" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631553": { "compartment": "compartment_984", "id": "reaction_10631553", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631532" ], "products": [ "species_10630560", "species_10631550" ], "modifiers": [ [ "species_10631532", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632145": { "compartment": "compartment_984", "id": "reaction_10632145", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631644" ], "products": [ "species_10631571", "species_10632142" ], "modifiers": [ [ "species_10631644", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632289": { "compartment": "compartment_876", "id": "reaction_10632289", "reactome": "R-CEL-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632239" ], "products": [ "species_10632266", "species_10632259" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637134": { "compartment": "compartment_876", "id": "reaction_10637134", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10615940": { "compartment": "compartment_984", "id": "reaction_10615940", "reactome": "R-CEL-375135", "name": "Basigin binds Matrix metalloproteinase-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615936" ], "products": [ "species_10615938" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "Q8MQ86", "WBGene00017184", "G5ECC4", "WBGene00020646", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10661241": { "compartment": "compartment_984", "id": "reaction_10661241", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661234", "species_10661236" ], "modifiers": [ [ "species_10630560", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10661248": { "compartment": "compartment_984", "id": "reaction_10661248", "reactome": "R-CEL-8940561", "name": "MMP7 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661243", "species_10661238", "species_10661245", "species_10661236" ], "modifiers": [ [ "species_10630596", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632526": { "compartment": "compartment_984", "id": "reaction_10632526", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632524", "species_10632425" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632314": { "compartment": "compartment_984", "id": "reaction_10632314", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631880" ], "products": [ "species_10632312", "species_10630632" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632506": { "compartment": "compartment_984", "id": "reaction_10632506", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632407", "species_10632504" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632165": { "compartment": "compartment_17963", "id": "reaction_10632165", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632163" ], "products": [ "species_10631589" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10632547": { "compartment": "compartment_984", "id": "reaction_10632547", "reactome": "R-CEL-1604763", "name": "Autocatalytic activation of MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632332" ], "products": [ "species_10632544", "species_10630596" ], "modifiers": [ [ "species_10632332", "catalyst" ], [ "species_1604783", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "CHEBI:24505", "species_444761" ] }, "reaction_10661268": { "compartment": "compartment_984", "id": "reaction_10661268", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661265" ], "modifiers": [ [ "species_10630542", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640453": { "compartment": "compartment_984", "id": "reaction_10640453", "reactome": "R-CEL-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636728" ], "products": [ "species_10640444", "species_10640450" ], "modifiers": [ [ "species_10631487", "catalyst" ] ], "additional_components": [ "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632486": { "compartment": "compartment_984", "id": "reaction_10632486", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632427" ], "products": [ "species_10632483", "species_10630542" ], "modifiers": [ [ "species_10632427", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640402": { "compartment": "compartment_876", "id": "reaction_10640402", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10640377" ], "modifiers": [ [ "species_10640399", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDW5", "WBGene00000074", "Q19844", "WBGene00017865", "G5EFD5", "WBGene00006804", "Q9N5X7", "WBGene00016423" ] }, "reaction_10649493": { "compartment": "compartment_5460", "id": "reaction_10649493", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696409" ], "products": [ "species_113556", "species_113548", "species_5693978" ], "modifiers": [ [ "species_10649490", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10632389": { "compartment": "compartment_984", "id": "reaction_10632389", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631787" ], "products": [ "species_10632386", "species_10630578" ], "modifiers": [ [ "species_10631787", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631453": { "compartment": "compartment_984", "id": "reaction_10631453", "reactome": "R-CEL-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430" ], "products": [ "species_10630506" ], "modifiers": [ [ "species_10631450", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632264": { "compartment": "compartment_984", "id": "reaction_10632264", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237" ], "products": [ "species_10632259", "species_10631532" ], "modifiers": [ [ "species_10632261", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631751": { "compartment": "compartment_984", "id": "reaction_10631751", "reactome": "R-CEL-1592362", "name": "Activation of proMMP7 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631708" ], "products": [ "species_10630596", "species_10631726" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632124": { "compartment": "compartment_17963", "id": "reaction_10632124", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632044" ], "products": [ "species_10632122" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10631903": { "compartment": "compartment_984", "id": "reaction_10631903", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631862" ], "products": [ "species_10631898", "species_10631880" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631945": { "compartment": "compartment_984", "id": "reaction_10631945", "reactome": "R-CEL-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623212", "species_10631862" ], "products": [ "species_10631943" ], "modifiers": [], "additional_components": [ "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631594": { "compartment": "compartment_984", "id": "reaction_10631594", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631571" ], "products": [ "species_10615936" ], "modifiers": [ [ "species_10631591", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10630637": { "compartment": "compartment_984", "id": "reaction_10630637", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630506" ], "products": [], "modifiers": [ [ "species_10630634", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640438": { "compartment": "compartment_876", "id": "reaction_10640438", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445" ], "products": [ "species_10640436" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632671": { "compartment": "compartment_17963", "id": "reaction_10632671", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632122" ], "products": [ "species_10632669" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637180": { "compartment": "compartment_876", "id": "reaction_10637180", "reactome": "R-CEL-2534240", "name": "HSPG2 (perlecan) degradation by MMP14, MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10637177", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631608": { "compartment": "compartment_984", "id": "reaction_10631608", "reactome": "R-CEL-1592314", "name": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10631605", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631690": { "compartment": "compartment_876", "id": "reaction_10631690", "reactome": "R-CEL-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631680", "species_10631686" ], "products": [ "species_10631688" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631514": { "compartment": "compartment_984", "id": "reaction_10631514", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631511", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632294": { "compartment": "compartment_876", "id": "reaction_10632294", "reactome": "R-CEL-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632266" ], "products": [ "species_10632291", "species_10631550" ], "modifiers": [ [ "species_10632266", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10608300": { "compartment": "compartment_7660", "id": "reaction_10608300", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608291", "species_10608295" ], "products": [ "species_10608297" ], "modifiers": [ [ "species_10608295", "catalyst" ] ], "additional_components": [ "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "G5EC44", "WBGene00003417", "Q95Y97", "WBGene00019767", "Q95Q27", "WBGene00001997", "G5EGG2", "WBGene00001998", "G5EFI9", "WBGene00002042", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10636084": { "compartment": "compartment_12045", "id": "reaction_10636084", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10603812", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10636089": { "compartment": "compartment_12045", "id": "reaction_10636089", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10636086", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620836": { "compartment": "compartment_876", "id": "reaction_10620836", "reactome": "R-CEL-432110", "name": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605504" ], "products": [ "species_10620831" ], "modifiers": [ [ "species_10620833", "catalyst" ] ], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102" ] }, "reaction_10615241": { "compartment": "compartment_984", "id": "reaction_10615241", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_377604", "species_10615215" ], "products": [ "species_10615239" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "species_74016", "species_109496", "species_266099", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615217": { "compartment": "compartment_876", "id": "reaction_10615217", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615193", "species_10615213" ], "products": [ "species_10615215" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856", "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10616380": { "compartment": "compartment_70101", "id": "reaction_10616380", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616372" ], "products": [ "species_10615209", "species_10616378" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856", "WBGene00000812", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10620443": { "compartment": "compartment_70101", "id": "reaction_10620443", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613787", "species_10615195" ], "products": [ "species_10620441" ], "modifiers": [], "additional_components": [ "WBGene00016416", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615181": { "compartment": "compartment_70101", "id": "reaction_10615181", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615177", "species_179856", "species_10615172" ], "products": [ "species_10615179" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10616374": { "compartment": "compartment_876", "id": "reaction_10616374", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615213", "species_10615239" ], "products": [ "species_10616372" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615259": { "compartment": "compartment_70101", "id": "reaction_10615259", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10615256", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10615232": { "compartment": "compartment_70101", "id": "reaction_10615232", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615179", "species_10615191" ], "products": [ "species_10615193" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856", "WBGene00006771", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10620451": { "compartment": "compartment_70101", "id": "reaction_10620451", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620441" ], "products": [ "species_29370", "species_10620448" ], "modifiers": [ [ "species_10620441", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "Q18462", "WBGene00016416", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10621581": { "compartment": "compartment_876", "id": "reaction_10621581", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621575" ], "products": [ "species_10621579" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615245": { "compartment": "compartment_70101", "id": "reaction_10615245", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10615228" ], "products": [ "species_10615243" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "Q9N5D3", "WBGene00004947", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615237": { "compartment": "compartment_70101", "id": "reaction_10615237", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615204" ], "products": [ "species_29370", "species_10615226" ], "modifiers": [ [ "species_10615204", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615230": { "compartment": "compartment_70101", "id": "reaction_10615230", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615226", "species_10602400" ], "products": [ "species_10615228" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "WBGene00004774", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10626050": { "compartment": "compartment_70101", "id": "reaction_10626050", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617231", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10615207": { "compartment": "compartment_70101", "id": "reaction_10615207", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615197", "species_113592" ], "products": [ "species_29370", "species_10615204" ], "modifiers": [ [ "species_10615197", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10616370": { "compartment": "compartment_70101", "id": "reaction_10616370", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616367" ], "products": [ "species_29370", "species_10615195" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "species_266099", "P34446", "WBGene00003929", "species_179856", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "WBGene00005077" ] }, "reaction_10615199": { "compartment": "compartment_70101", "id": "reaction_10615199", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10615195" ], "products": [ "species_10615197" ], "modifiers": [], "additional_components": [ "WBGene00002213", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10599384", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10659512": { "compartment": "compartment_876", "id": "reaction_10659512", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10599379": { "compartment": "compartment_70101", "id": "reaction_10599379", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10599376", "catalyst" ] ], "additional_components": [ "Q09474", "WBGene00016201", "species_71185" ] }, "reaction_10599408": { "compartment": "compartment_70101", "id": "reaction_10599408", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10599405", "catalyst" ] ], "additional_components": [ "species_113531", "Q19341", "WBGene00010595" ] }, "reaction_10625269": { "compartment": "compartment_70101", "id": "reaction_10625269", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10599398": { "compartment": "compartment_70101", "id": "reaction_10599398", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10599395", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10635687": { "compartment": "compartment_17951", "id": "reaction_10635687", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10635685": { "compartment": "compartment_17951", "id": "reaction_10635685", "reactome": "R-CEL-2066781", "name": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_192314", "species_2066765" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10635683": { "compartment": "compartment_17951", "id": "reaction_10635683", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635681": { "compartment": "compartment_17951", "id": "reaction_10635681", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10635600": { "compartment": "compartment_17957", "id": "reaction_10635600", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10635679": { "compartment": "compartment_17951", "id": "reaction_10635679", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635597": { "compartment": "compartment_12045", "id": "reaction_10635597", "reactome": "R-CEL-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10635602": { "compartment": "compartment_17957", "id": "reaction_10635602", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10660616": { "compartment": "compartment_70101", "id": "reaction_10660616", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660614" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660604": { "compartment": "compartment_70101", "id": "reaction_10660604", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660596" ], "products": [ "species_10660602" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "P34707", "WBGene00004804" ] }, "reaction_10666119": { "compartment": "compartment_70101", "id": "reaction_10666119", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10660612" ], "products": [ "species_10666117" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "P34707", "WBGene00004804", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34707", "WBGene00004804", "LigandDisplayForward?ligandId=7045", "Q17391", "WBGene00000838", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "Q23457", "WBGene00004320" ] }, "reaction_10644873": { "compartment": "compartment_876", "id": "reaction_10644873", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644870" ], "products": [ "species_29370", "species_10644868" ], "modifiers": [ [ "species_10644870", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10626976": { "compartment": "compartment_20699", "id": "reaction_10626976", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_975819", "species_964752" ], "modifiers": [ [ "species_10626973", "catalyst" ] ], "additional_components": [ "species_216667", "Q2PJ74", "WBGene00010284" ] }, "reaction_10649008": { "compartment": "compartment_161320", "id": "reaction_10649008", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10649005", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10626984": { "compartment": "compartment_20699", "id": "reaction_10626984", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975819", "species_914003" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10626981", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10649043": { "compartment": "compartment_17963", "id": "reaction_10649043", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10628551": { "compartment": "compartment_20699", "id": "reaction_10628551", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10628548", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604705", "species_10604589" ], "products": [ "species_10604583", "species_10604707" ], "modifiers": [], "additional_components": [ "WBGene00001372", "Q9U221", "WBGene00013241", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10604711": { "compartment": "compartment_7660", "id": "reaction_10604711", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604605", "species_10604705" ], "products": [ "species_10604707", "species_10604576" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10626216": { "compartment": "compartment_20699", "id": "reaction_10626216", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626190": { "compartment": "compartment_20699", "id": "reaction_10626190", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626214": { "compartment": "compartment_20699", "id": "reaction_10626214", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10661498": { "compartment": "compartment_70101", "id": "reaction_10661498", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627710" ], "products": [ "species_29370", "species_10661496" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10620826": { "compartment": "compartment_876", "id": "reaction_10620826", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10620823", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10620807": { "compartment": "compartment_876", "id": "reaction_10620807", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10620804", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10664833": { "compartment": "compartment_12045", "id": "reaction_10664833", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664831" ], "products": [ "species_10620890" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10626899": { "compartment": "compartment_876", "id": "reaction_10626899", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626896", "catalyst" ] ], "additional_components": [ "G5ECH3", "WBGene00000233", "Q95QT7", "WBGene00001594", "O17274", "WBGene00020836", "Q9N517", "WBGene00021437", "Q17328", "WBGene00001592", "O17402", "WBGene00017314", "A0A1N7SYW0", "WBGene00021146", "Q7YTP9", "WBGene00008076", "Q22741", "WBGene00020767", "Q09453", "WBGene00001586", "G5EBR3", "WBGene00001591", "Q95Q97", "WBGene00000232", "species_159549", "A0A4V0IN81", "WBGene00001587", "G5EEZ3", "WBGene00001593", "A0A4V0IK40", "WBGene00008022", "P90876", "WBGene00009790" ] }, "reaction_10619119": { "compartment": "compartment_876", "id": "reaction_10619119", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618195", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664726": { "compartment": "compartment_12045", "id": "reaction_10664726", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664722", "species_10664720" ], "products": [ "species_10664724" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10628530": { "compartment": "compartment_876", "id": "reaction_10628530", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628525", "species_10628428" ], "products": [ "species_10628527" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10665455": { "compartment": "compartment_876", "id": "reaction_10665455", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10665452", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10665459": { "compartment": "compartment_876", "id": "reaction_10665459", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665457", "species_114523" ], "products": [ "species_10665452" ], "modifiers": [], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10620923": { "compartment": "compartment_984", "id": "reaction_10620923", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10620920", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "species_376186", "O62305", "WBGene00006779", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "G5ECY0", "WBGene00001006" ] }, "reaction_10628532": { "compartment": "compartment_876", "id": "reaction_10628532", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616836", "species_10605064" ], "products": [ "species_10628428" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626927", "catalyst" ] ], "additional_components": [ "Q17511", "WBGene00007191", "species_352003", "O18276", "WBGene00001512" ] }, "reaction_10626740": { "compartment": "compartment_876", "id": "reaction_10626740", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626737", "catalyst" ] ], "additional_components": [ "Q18812", "WBGene00008280", "P41849", "WBGene00020605", "Q9U2E2", "WBGene00012915", "Q9GQ00", "WBGene00003386", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "Q17511", "WBGene00007191", "O18276", "WBGene00001512", "Q6BET0", "WBGene00008551", "G5EEC1", "WBGene00013746", "G5ECN1", "WBGene00013914", "A0A3P6NNS2", "WBGene00017389", "O17041", "WBGene00020528", "Q95Y52", "WBGene00022106", "Q10052", "WBGene00001588", "species_352003", "Q9NA62", "WBGene00013517", "X5LVB0", "WBGene00017399", "Q9U358", "WBGene00012099", "Q21420", "WBGene00010741", "P91985", "WBGene00008223", "G5EEX8", "WBGene00009799", "G5EDN0", "WBGene00018880", "Q21005", "WBGene00010275", "H2KYN9", "WBGene00020657" ] }, "reaction_10628535": { "compartment": "compartment_70101", "id": "reaction_10628535", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10628527", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675" ] }, "reaction_10621327": { "compartment": "compartment_876", "id": "reaction_10621327", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ], [ "species_10621325", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_376186", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "P04630", "WBGene00000285", "G5EGQ9", "WBGene00003774", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_159549", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5ECY0", "WBGene00001006", "G5EDZ8", "WBGene00000288" ] }, "reaction_10624678": { "compartment": "compartment_70101", "id": "reaction_10624678", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624675", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10624481": { "compartment": "compartment_876", "id": "reaction_10624481", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624478", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10624680": { "compartment": "compartment_984", "id": "reaction_10624680", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624673", "species_372533" ], "products": [ "species_10624675" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997", "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10664976": { "compartment": "compartment_70101", "id": "reaction_10664976", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664969", "species_113592" ], "products": [ "species_29370", "species_10664973" ], "modifiers": [ [ "species_10664969", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518" ] }, "reaction_10619115": { "compartment": "compartment_984", "id": "reaction_10619115", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618182" ], "products": [ "species_10618184" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10618187": { "compartment": "compartment_876", "id": "reaction_10618187", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10624682": { "compartment": "compartment_984", "id": "reaction_10624682", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624476", "species_372533" ], "products": [ "species_10624478" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043", "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10619117": { "compartment": "compartment_984", "id": "reaction_10619117", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618193" ], "products": [ "species_10618195" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664985": { "compartment": "compartment_70101", "id": "reaction_10664985", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10664981" ], "products": [ "species_10664983" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00000553", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10626307": { "compartment": "compartment_876", "id": "reaction_10626307", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10626304", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10618079": { "compartment": "compartment_876", "id": "reaction_10618079", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608448", "species_10615689" ], "products": [ "species_10618077" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942" ] }, "reaction_10621804": { "compartment": "compartment_70101", "id": "reaction_10621804", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081", "species_113592", "species_10604515" ], "products": [ "species_29370", "species_10621801" ], "modifiers": [ [ "species_10604515", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401", "Q21465", "WBGene00019727", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P39745", "WBGene00003401", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10624055": { "compartment": "compartment_876", "id": "reaction_10624055", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608453", "species_10618077" ], "products": [ "species_10618081", "species_29372", "species_29420" ], "modifiers": [ [ "species_10609937", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10621565": { "compartment": "compartment_876", "id": "reaction_10621565", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621561", "species_10615689" ], "products": [ "species_10621563" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q5WRR1", "WBGene00006942", "Q18677", "WBGene00000964" ] }, "reaction_10615724": { "compartment": "compartment_876", "id": "reaction_10615724", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615720", "species_10615689" ], "products": [ "species_10615722" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856" ] }, "reaction_10621806": { "compartment": "compartment_70101", "id": "reaction_10621806", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615689" ], "products": [ "species_29370", "species_10615718" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00005077" ] }, "reaction_10621554": { "compartment": "compartment_70101", "id": "reaction_10621554", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10615722" ], "products": [ "species_10621552" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "species_113592", "Q5WRR1", "WBGene00006942", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10618083": { "compartment": "compartment_17940", "id": "reaction_10618083", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081" ], "products": [ "species_10618081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791" ] }, "reaction_10638811": { "compartment": "compartment_7660", "id": "reaction_10638811", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638788", "species_10638181" ], "products": [ "species_10638809", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10658568": { "compartment": "compartment_7660", "id": "reaction_10658568", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658564" ], "products": [ "species_10658566" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658586": { "compartment": "compartment_70101", "id": "reaction_10658586", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10658582" ], "products": [ "species_10658584" ], "modifiers": [], "additional_components": [ "WBGene00017131", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658588": { "compartment": "compartment_70101", "id": "reaction_10658588", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658582" ], "products": [ "species_10638786" ], "modifiers": [ [ "species_10658584", "inhibitor" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658600": { "compartment": "compartment_7660", "id": "reaction_10658600", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658596", "species_10658594" ], "products": [ "species_10658598" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "WBGene00001585", "Q19862", "WBGene00009203", "Q21501", "WBGene00001585", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10622688": { "compartment": "compartment_70101", "id": "reaction_10622688", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_450386" ], "products": [ "species_10622643" ], "modifiers": [], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10622708": { "compartment": "compartment_70101", "id": "reaction_10622708", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622694", "species_10622682" ], "products": [ "species_10622706" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "Q9BLA0", "WBGene00016489", "P41932", "WBGene00003920", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10604062": { "compartment": "compartment_7660", "id": "reaction_10604062", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600734", "species_10600755", "species_10600767", "species_10604056", "species_10600739" ], "products": [ "species_10604060" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10620715": { "compartment": "compartment_70101", "id": "reaction_10620715", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10620712", "catalyst" ] ], "additional_components": [ "A5Z2V7", "WBGene00008533", "G5EG59", "WBGene00000798", "Q9BKR2", "WBGene00021613", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "P90922", "WBGene00010622", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q19103", "WBGene00008502", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10649092": { "compartment": "compartment_70101", "id": "reaction_10649092", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_430042", "species_29356" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10649089", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10622619": { "compartment": "compartment_70101", "id": "reaction_10622619", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622615", "species_10606995" ], "products": [ "species_10622617" ], "modifiers": [], "additional_components": [ "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10620627": { "compartment": "compartment_70101", "id": "reaction_10620627", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620593", "species_29356" ], "products": [ "species_10620595", "species_430004" ], "modifiers": [ [ "species_10620624", "catalyst" ] ], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479", "Q8ITV6", "WBGene00021551", "O62255", "WBGene00003582", "Q21740", "WBGene00011036" ] }, "reaction_10604054": { "compartment": "compartment_7660", "id": "reaction_10604054", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604050", "species_10600698" ], "products": [ "species_10604052" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797" ] }, "reaction_10622686": { "compartment": "compartment_70101", "id": "reaction_10622686", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622645", "species_450523" ], "products": [ "species_10622647" ], "modifiers": [], "additional_components": [ "WBGene00009532", "Q20155", "WBGene00009532" ] }, "reaction_10604044": { "compartment": "compartment_7660", "id": "reaction_10604044", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604038" ], "products": [ "species_10604042", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10622668": { "compartment": "compartment_70101", "id": "reaction_10622668", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622615" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10623677": { "compartment": "compartment_70101", "id": "reaction_10623677", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606995", "species_10622653" ], "products": [ "species_10623675" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10604761": { "compartment": "compartment_7660", "id": "reaction_10604761", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604036", "species_10603997" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10610139": { "compartment": "compartment_70101", "id": "reaction_10610139", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610135", "species_10610130" ], "products": [ "species_10610137" ], "modifiers": [], "additional_components": [ "WBGene00017746", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920" ] }, "reaction_10603876": { "compartment": "compartment_7660", "id": "reaction_10603876", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850", "species_10603872", "species_10603866" ], "products": [ "species_10603874" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00005015", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10604070": { "compartment": "compartment_7660", "id": "reaction_10604070", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10600734", "species_10604068", "species_10600767", "species_10600739" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "WBGene00003904" ] }, "reaction_10622665": { "compartment": "compartment_70101", "id": "reaction_10622665", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620691", "species_10620605", "species_10622647", "species_10620612", "species_10622661" ], "products": [ "species_10622663" ], "modifiers": [], "additional_components": [ "Q93830", "WBGene00010325", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001", "WBGene00021929", "Q20155", "WBGene00009532", "WBGene00003582", "WBGene00012730", "G5EG59", "WBGene00000798", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9BHK7", "WBGene00012730", "O62255", "WBGene00003582", "Q9XXD2", "WBGene00012966", "Q20155", "WBGene00009532", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10622656": { "compartment": "compartment_70101", "id": "reaction_10622656", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622653" ], "modifiers": [ [ "species_10609568", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10604040": { "compartment": "compartment_7660", "id": "reaction_10604040", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604004", "species_10604036" ], "products": [ "species_10604038" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411" ] }, "reaction_10603908": { "compartment": "compartment_7660", "id": "reaction_10603908", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599879", "species_10599884" ], "products": [ "species_10599886" ], "modifiers": [], "additional_components": [ "WBGene00009141", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10604006": { "compartment": "compartment_7660", "id": "reaction_10604006", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604002", "species_10603997" ], "products": [ "species_10604004" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10603901": { "compartment": "compartment_7660", "id": "reaction_10603901", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603894" ], "products": [ "species_10603899" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10620637": { "compartment": "compartment_70101", "id": "reaction_10620637", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620591", "species_429974" ], "products": [ "species_10620593" ], "modifiers": [], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077" ] }, "reaction_10625887": { "compartment": "compartment_70101", "id": "reaction_10625887", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625883", "species_10625863" ], "products": [ "species_10625885" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00004880", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10622684": { "compartment": "compartment_70101", "id": "reaction_10622684", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_113592" ], "products": [ "species_29370", "species_10622682" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10603897": { "compartment": "compartment_7660", "id": "reaction_10603897", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603889" ], "products": [ "species_10603894" ], "modifiers": [ [ "species_10603889", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603892": { "compartment": "compartment_7660", "id": "reaction_10603892", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10603882" ], "products": [ "species_111349", "species_10603889" ], "modifiers": [ [ "species_10603882", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610188": { "compartment": "compartment_13231", "id": "reaction_10610188", "reactome": "R-CEL-191830", "name": "snRNP nuclear import and release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610137" ], "products": [ "species_10610180", "species_10610135", "species_10610186" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "A7LPI7", "WBGene00007702", "WBGene00017746", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "CHEBI:1604", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10603906": { "compartment": "compartment_7660", "id": "reaction_10603906", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603899", "species_77087" ], "products": [ "species_10599965", "species_10601853", "species_10603872", "species_10603903", "species_77502" ], "modifiers": [ [ "species_10603899", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603856": { "compartment": "compartment_7660", "id": "reaction_10603856", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603848", "species_10603854" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604759": { "compartment": "compartment_7660", "id": "reaction_10604759", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604755" ], "products": [ "species_10604757", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10620635": { "compartment": "compartment_70101", "id": "reaction_10620635", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429926", "species_29356" ], "products": [ "species_429925", "species_430042" ], "modifiers": [ [ "species_10620632", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10603852": { "compartment": "compartment_7660", "id": "reaction_10603852", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604066": { "compartment": "compartment_7660", "id": "reaction_10604066", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10604064", "species_112165", "species_10600767" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "Q93233", "WBGene00003904", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304" ] }, "reaction_10603910": { "compartment": "compartment_7660", "id": "reaction_10603910", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599965", "species_10599886" ], "products": [ "species_10599967" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10603885": { "compartment": "compartment_7660", "id": "reaction_10603885", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603878" ], "products": [ "species_113550", "species_10603882" ], "modifiers": [ [ "species_10603878", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603880": { "compartment": "compartment_7660", "id": "reaction_10603880", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10603874" ], "products": [ "species_10603878" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610151": { "compartment": "compartment_70101", "id": "reaction_10610151", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610143" ], "products": [ "species_10610130" ], "modifiers": [ [ "species_10610148", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:2274", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "WBGene00011631" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10604052" ], "products": [ "species_10604056" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10659874": { "compartment": "compartment_70101", "id": "reaction_10659874", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659871", "species_113592" ], "products": [ "species_29370", "species_10659858" ], "modifiers": [ [ "species_10659871", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10659867": { "compartment": "compartment_70101", "id": "reaction_10659867", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659858", "species_113592" ], "products": [ "species_29370", "species_10659864" ], "modifiers": [ [ "species_10659858", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10641084": { "compartment": "compartment_7660", "id": "reaction_10641084", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641071" ], "products": [ "species_113582", "species_10641081" ], "modifiers": [ [ "species_10641067", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10641029": { "compartment": "compartment_70101", "id": "reaction_10641029", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641021" ], "products": [ "species_29370", "species_10641016" ], "modifiers": [ [ "species_10641021", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10637600": { "compartment": "compartment_70101", "id": "reaction_10637600", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635196", "species_74016", "species_10604898" ], "products": [ "species_10637574" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "species_912516", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641019": { "compartment": "compartment_70101", "id": "reaction_10641019", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641016" ], "products": [ "species_29370", "species_10641014", "species_10604898" ], "modifiers": [ [ "species_10641016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641025": { "compartment": "compartment_70101", "id": "reaction_10641025", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620916", "species_10604898" ], "products": [ "species_10641021" ], "modifiers": [ [ "species_10641023", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641069": { "compartment": "compartment_7660", "id": "reaction_10641069", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641063" ], "products": [ "species_10641067" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10640879": { "compartment": "compartment_876", "id": "reaction_10640879", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640874" ], "products": [ "species_10640857", "species_10605064", "species_10640864" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "P51875", "WBGene00001648", "Q9N2V6", "WBGene00001678" ] }, "reaction_10640877": { "compartment": "compartment_876", "id": "reaction_10640877", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640870", "species_29438" ], "products": [ "species_10640874", "species_29420" ], "modifiers": [ [ "species_10640870", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681" ] }, "reaction_10641175": { "compartment": "compartment_70101", "id": "reaction_10641175", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641169" ], "products": [ "species_10641173" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10603920": { "compartment": "compartment_5460", "id": "reaction_10603920", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77252", "species_113526" ], "products": [ "species_77253", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603922": { "compartment": "compartment_5460", "id": "reaction_10603922", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603961": { "compartment": "compartment_5460", "id": "reaction_10603961", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10613700": { "compartment": "compartment_70101", "id": "reaction_10613700", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10613697", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10662871": { "compartment": "compartment_161320", "id": "reaction_10662871", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662869" ], "products": [ "species_10662867", "species_350136" ], "modifiers": [], "additional_components": [ "species_350136", "Q93212", "WBGene00004944", "WBGene00004944" ] }, "reaction_10662875": { "compartment": "compartment_7660", "id": "reaction_10662875", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8963912", "species_10616155" ], "products": [ "species_10662873" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "species_8963912" ] }, "reaction_10629238": { "compartment": "compartment_876", "id": "reaction_10629238", "reactome": "R-CEL-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629233" ], "products": [ "species_29370", "species_10629235" ], "modifiers": [ [ "species_10629233", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643411": { "compartment": "compartment_7660", "id": "reaction_10643411", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10636603": { "compartment": "compartment_984", "id": "reaction_10636603", "reactome": "R-CEL-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636599", "species_10631599" ], "products": [ "species_10636601" ], "modifiers": [], "additional_components": [ "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881", "WBGene00006787", "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "Q06561", "WBGene00006787", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881" ] }, "reaction_10614244": { "compartment": "compartment_12045", "id": "reaction_10614244", "reactome": "R-CEL-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614257": { "compartment": "compartment_17960", "id": "reaction_10614257", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10614254", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603732": { "compartment": "compartment_12045", "id": "reaction_10603732", "reactome": "R-CEL-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10603729", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614249": { "compartment": "compartment_17960", "id": "reaction_10614249", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10650224": { "compartment": "compartment_12045", "id": "reaction_10650224", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6786220", "species_29368" ], "products": [ "species_29366", "species_29356", "species_6786225" ], "modifiers": [ [ "species_10650221", "catalyst" ] ], "additional_components": [ "WBGene00011830" ] }, "reaction_10614237": { "compartment": "compartment_12045", "id": "reaction_10614237", "reactome": "R-CEL-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10614234", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614264": { "compartment": "compartment_12045", "id": "reaction_10614264", "reactome": "R-CEL-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614262": { "compartment": "compartment_17960", "id": "reaction_10614262", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10614259", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10610411": { "compartment": "compartment_70101", "id": "reaction_10610411", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193079" ], "products": [ "species_29366", "species_29460", "species_193066", "species_29356" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10603727": { "compartment": "compartment_17960", "id": "reaction_10603727", "reactome": "R-CEL-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603819": { "compartment": "compartment_17960", "id": "reaction_10603819", "reactome": "R-CEL-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614232": { "compartment": "compartment_17960", "id": "reaction_10614232", "reactome": "R-CEL-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10603636", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603721": { "compartment": "compartment_17960", "id": "reaction_10603721", "reactome": "R-CEL-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605850": { "compartment": "compartment_17957", "id": "reaction_10605850", "reactome": "R-CEL-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603725": { "compartment": "compartment_17960", "id": "reaction_10603725", "reactome": "R-CEL-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614269": { "compartment": "compartment_12045", "id": "reaction_10614269", "reactome": "R-CEL-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603723": { "compartment": "compartment_17957", "id": "reaction_10603723", "reactome": "R-CEL-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614252": { "compartment": "compartment_12045", "id": "reaction_10614252", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614242": { "compartment": "compartment_12045", "id": "reaction_10614242", "reactome": "R-CEL-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614276": { "compartment": "compartment_12045", "id": "reaction_10614276", "reactome": "R-CEL-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614274": { "compartment": "compartment_12045", "id": "reaction_10614274", "reactome": "R-CEL-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614271", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603817": { "compartment": "compartment_12045", "id": "reaction_10603817", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10637598": { "compartment": "compartment_70101", "id": "reaction_10637598", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637578" ], "products": [ "species_10637596" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10638009": { "compartment": "compartment_70101", "id": "reaction_10638009", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473610" ], "products": [ "species_10636648" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10626966": { "compartment": "compartment_70101", "id": "reaction_10626966", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10626963", "catalyst" ] ], "additional_components": [ "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10602452": { "compartment": "compartment_70101", "id": "reaction_10602452", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473604" ], "products": [ "species_10602450" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637084": { "compartment": "compartment_70101", "id": "reaction_10637084", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_74016", "species_83910" ], "modifiers": [ [ "species_10602105", "catalyst" ] ], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10636806": { "compartment": "compartment_70101", "id": "reaction_10636806", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10636803", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10637063": { "compartment": "compartment_2514888", "id": "reaction_10637063", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637061" ], "products": [ "species_10637052", "species_10637059" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10602107": { "compartment": "compartment_70101", "id": "reaction_10602107", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10602103" ], "products": [ "species_10602105" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10637131": { "compartment": "compartment_2514888", "id": "reaction_10637131", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637121", "species_2530486" ], "products": [ "species_10637057", "species_111294" ], "modifiers": [ [ "species_10637128", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10626938": { "compartment": "compartment_984", "id": "reaction_10626938", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975591", "species_109276" ], "products": [ "species_426576", "species_975590" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10637150": { "compartment": "compartment_70101", "id": "reaction_10637150", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637140", "species_2534019" ], "products": [ "species_10637048", "species_76194" ], "modifiers": [ [ "species_10637145", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "WBGene00020549" ] }, "reaction_10642008": { "compartment": "compartment_5460", "id": "reaction_10642008", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10642005", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10637081": { "compartment": "compartment_70101", "id": "reaction_10637081", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602105" ], "products": [ "species_30991", "species_10602103" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10638007": { "compartment": "compartment_70101", "id": "reaction_10638007", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10626954" ], "products": [ "species_29366", "species_10626952" ], "modifiers": [ [ "species_10638004", "catalyst" ] ], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10637175": { "compartment": "compartment_70101", "id": "reaction_10637175", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637156" ], "products": [ "species_10637140", "species_174390" ], "modifiers": [ [ "species_10637172", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q965Y1", "WBGene00003129", "species_880069", "H1UBK1", "WBGene00003130" ] }, "reaction_10636780": { "compartment": "compartment_70101", "id": "reaction_10636780", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_70106", "species_2864103", "species_30927" ], "modifiers": [ [ "species_10636772", "catalyst" ], [ "species_10636778", "catalyst" ] ], "additional_components": [ "species_2534407", "CHEBI:70761", "CHEBI:70760", "CHEBI:70762", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10636650": { "compartment": "compartment_70101", "id": "reaction_10636650", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636648" ], "products": [ "species_10602448", "species_2473616" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10638750": { "compartment": "compartment_70101", "id": "reaction_10638750", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10602103" ], "products": [ "species_10638748" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q94288", "WBGene00000287", "A8WI01", "WBGene00000562", "Q18136", "WBGene00006861", "species_74016", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q7Z205", "WBGene00000563", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "O02159", "WBGene00020378", "Q9N4C1", "WBGene00022295", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10636642": { "compartment": "compartment_984", "id": "reaction_10636642", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636634", "species_2395761" ], "products": [ "species_10636636" ], "modifiers": [], "additional_components": [ "WBGene00011726", "G5EEB8", "WBGene00011726", "species_5623649" ] }, "reaction_10636646": { "compartment": "compartment_70101", "id": "reaction_10636646", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473616" ], "products": [ "species_10636644" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637319": { "compartment": "compartment_70101", "id": "reaction_10637319", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10637309" ], "products": [ "species_10637317" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "O02217", "WBGene00007710", "P36609", "WBGene00003564", "species_74016", "O02217", "WBGene00007710" ] }, "reaction_10636629": { "compartment": "compartment_70101", "id": "reaction_10636629", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10626950" ], "products": [ "species_10626954" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648" ] }, "reaction_10626956": { "compartment": "compartment_70101", "id": "reaction_10626956", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626950", "species_975590" ], "products": [ "species_10626952" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10636640": { "compartment": "compartment_984", "id": "reaction_10636640", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636636", "species_10636597" ], "products": [ "species_10636638" ], "modifiers": [], "additional_components": [ "G5EEB8", "WBGene00011726", "species_5623649", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "G5EEB8", "WBGene00011726", "species_5623649", "O44578", "WBGene00022808" ] }, "reaction_10636485": { "compartment": "compartment_7660", "id": "reaction_10636485", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636483", "species_10605870" ], "products": [ "species_10636465" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00004043", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636457": { "compartment": "compartment_7660", "id": "reaction_10636457", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10636183" ], "products": [ "species_10636455" ], "modifiers": [ [ "species_10636174", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636453": { "compartment": "compartment_7660", "id": "reaction_10636453", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636196" ], "products": [ "species_113582", "species_10636183", "species_10636451" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "species_113531", "Q9GYI0", "WBGene00017920", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636176": { "compartment": "compartment_7660", "id": "reaction_10636176", "reactome": "R-CEL-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10598308" ], "products": [ "species_10636174" ], "modifiers": [], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "WBGene00003020", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636495": { "compartment": "compartment_7660", "id": "reaction_10636495", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636200", "species_77087" ], "products": [ "species_10636196", "species_77502" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "WBGene00004781" ] }, "reaction_10636435": { "compartment": "compartment_20699", "id": "reaction_10636435", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636427", "species_113592" ], "products": [ "species_29370", "species_10636432" ], "modifiers": [ [ "species_10636427", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017" ] }, "reaction_10636487": { "compartment": "compartment_7660", "id": "reaction_10636487", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636455" ], "products": [ "species_113582", "species_10636483" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636696": { "compartment": "compartment_20699", "id": "reaction_10636696", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636677" ], "products": [ "species_29370", "species_10636683" ], "modifiers": [ [ "species_10636693", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10636481": { "compartment": "compartment_7660", "id": "reaction_10636481", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636465" ], "products": [ "species_113582", "species_10636478" ], "modifiers": [ [ "species_10636465", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636203": { "compartment": "compartment_7660", "id": "reaction_10636203", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10636196", "species_113685" ], "products": [ "species_10636200", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10636196", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920" ] }, "reaction_10611278": { "compartment": "compartment_7660", "id": "reaction_10611278", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611266" ], "products": [ "species_113582", "species_10611276" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611288": { "compartment": "compartment_7660", "id": "reaction_10611288", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611283" ], "products": [ "species_113582", "species_10611286" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611197": { "compartment": "compartment_7660", "id": "reaction_10611197", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611166": { "compartment": "compartment_7660", "id": "reaction_10611166", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10664163": { "compartment": "compartment_70101", "id": "reaction_10664163", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664166": { "compartment": "compartment_70101", "id": "reaction_10664166", "reactome": "R-CEL-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664168": { "compartment": "compartment_70101", "id": "reaction_10664168", "reactome": "R-CEL-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620391": { "compartment": "compartment_70101", "id": "reaction_10620391", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10604843", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618931": { "compartment": "compartment_70101", "id": "reaction_10618931", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070" ], "products": [ "species_10615234" ], "modifiers": [], "additional_components": [ "WBGene00005077", "WBGene00005077" ] }, "reaction_10648796": { "compartment": "compartment_70101", "id": "reaction_10648796", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607380" ], "products": [ "species_10607378" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "WBGene00004467" ] }, "reaction_10648793": { "compartment": "compartment_7660", "id": "reaction_10648793", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648788" ], "products": [ "species_10648790", "species_10597874" ], "modifiers": [ [ "species_10648788", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10607397": { "compartment": "compartment_5460", "id": "reaction_10607397", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607392", "species_31649" ], "products": [ "species_113596", "species_10607394" ], "modifiers": [ [ "species_10607392", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187" ] }, "reaction_10607405": { "compartment": "compartment_5460", "id": "reaction_10607405", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607394", "species_73663" ], "products": [ "species_76633", "species_10607392" ], "modifiers": [ [ "species_10607402", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "WBGene00002855" ] }, "reaction_10654352": { "compartment": "compartment_70616", "id": "reaction_10654352", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654304", "species_10654348" ], "products": [ "species_10654350" ], "modifiers": [], "additional_components": [ "Q9BL33", "WBGene00022169", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "O18236", "WBGene00013308", "Q23098", "WBGene00012166", "species_113596", "P90789", "WBGene00008414", "O02267", "WBGene00009740", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596", "Q9N3H3", "WBGene00021800", "Q93931", "WBGene00011123", "O18236", "WBGene00013308", "P90789", "WBGene00008414", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q22619", "WBGene00020636", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q94360", "WBGene00012376", "Q9BL33", "WBGene00022169", "I2HAE1", "WBGene00021421", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "Q93873", "WBGene00001520", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "Q86NC2", "WBGene00020417", "Q17439", "WBGene00007113", "Q23098", "WBGene00012166", "species_113596", "O02267", "WBGene00009740", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q09644", "WBGene00014227" ] }, "reaction_10654384": { "compartment": "compartment_5460", "id": "reaction_10654384", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654336", "species_10654346", "species_10654331", "species_10654341" ], "products": [ "species_10654348" ], "modifiers": [], "additional_components": [ "WBGene00011123", "WBGene00021421", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596", "WBGene00007113", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10655491": { "compartment": "compartment_5460", "id": "reaction_10655491", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654329", "species_10654320", "species_10654324", "species_10654322", "species_10654313" ], "products": [ "species_10654331" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q9N3H3", "WBGene00021800", "species_113596", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10635778": { "compartment": "compartment_70101", "id": "reaction_10635778", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635776" ], "products": [ "species_10614163" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10614183": { "compartment": "compartment_70101", "id": "reaction_10614183", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614163" ], "products": [ "species_10614181" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10660554": { "compartment": "compartment_5460", "id": "reaction_10660554", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607390", "species_2162265" ], "products": [ "species_2162252", "species_10660546" ], "modifiers": [ [ "species_10660551", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10660627": { "compartment": "compartment_70101", "id": "reaction_10660627", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_71285", "species_10660619" ], "modifiers": [ [ "species_10660624", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10660565": { "compartment": "compartment_70101", "id": "reaction_10660565", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_10660557", "species_71285" ], "modifiers": [ [ "species_10660562", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10660587": { "compartment": "compartment_70101", "id": "reaction_10660587", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10643036" ], "products": [ "species_71285", "species_10660579" ], "modifiers": [ [ "species_10660584", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10620234": { "compartment": "compartment_876", "id": "reaction_10620234", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_10620228" ], "products": [ "species_10620232" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "G5EF96", "unc-40" ] }, "reaction_10661405": { "compartment": "compartment_17957", "id": "reaction_10661405", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634735" ], "products": [ "species_10634737" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10608764": { "compartment": "compartment_70101", "id": "reaction_10608764", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608761" ], "products": [ "species_29370", "species_10608706" ], "modifiers": [ [ "species_10608761", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608753": { "compartment": "compartment_70101", "id": "reaction_10608753", "reactome": "R-CEL-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608746", "species_10597908" ], "products": [ "species_10608750" ], "modifiers": [ [ "species_10608746", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10658941": { "compartment": "compartment_876", "id": "reaction_10658941", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658936", "species_113592" ], "products": [ "species_29370", "species_10658938" ], "modifiers": [ [ "species_10658936", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10658951": { "compartment": "compartment_876", "id": "reaction_10658951", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658938", "species_29356" ], "products": [ "species_10658936", "species_29372" ], "modifiers": [ [ "species_10658948", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "WBGene00004213" ] }, "reaction_10608704": { "compartment": "compartment_70101", "id": "reaction_10608704", "reactome": "R-CEL-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608631", "species_10597908" ], "products": [ "species_10608701" ], "modifiers": [ [ "species_10608631", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608735": { "compartment": "compartment_70101", "id": "reaction_10608735", "reactome": "R-CEL-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608731", "species_10608708" ], "products": [ "species_10608733" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532" ] }, "reaction_10608775": { "compartment": "compartment_70101", "id": "reaction_10608775", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608770", "species_10597908" ], "products": [ "species_10608772", "species_10608761" ], "modifiers": [ [ "species_10608770", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532", "WBGene00006727", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "P0CG71", "WBGene00006727", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10608757": { "compartment": "compartment_70101", "id": "reaction_10608757", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10602400" ], "products": [ "species_10608755" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10608779": { "compartment": "compartment_70101", "id": "reaction_10608779", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10608731" ], "products": [ "species_10608777" ], "modifiers": [], "additional_components": [ "WBGene00004829", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10608742": { "compartment": "compartment_70101", "id": "reaction_10608742", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608706", "species_10597908" ], "products": [ "species_10608739" ], "modifiers": [ [ "species_10608706", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608768": { "compartment": "compartment_70101", "id": "reaction_10608768", "reactome": "R-CEL-183072", "name": "EGFR non-clathrin mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608683", "species_10608631", "species_10608658", "species_10608639" ], "products": [ "species_10608685" ], "modifiers": [], "additional_components": [ "WBGene00001224", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10608710": { "compartment": "compartment_70101", "id": "reaction_10608710", "reactome": "R-CEL-182994", "name": "Assembly of EGFR complex in clathrin-coated vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10608706" ], "products": [ "species_10608708" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791" ] }, "reaction_10608634": { "compartment": "compartment_70101", "id": "reaction_10608634", "reactome": "R-CEL-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608626" ], "products": [ "species_29370", "species_10608631" ], "modifiers": [ [ "species_10608626", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608766": { "compartment": "compartment_70101", "id": "reaction_10608766", "reactome": "R-CEL-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608755", "species_10608528" ], "products": [ "species_10608761" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608759": { "compartment": "compartment_876", "id": "reaction_10608759", "reactome": "R-CEL-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608624" ], "products": [ "species_10608626" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608699": { "compartment": "compartment_70101", "id": "reaction_10608699", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608685", "species_10597908" ], "products": [ "species_10608696" ], "modifiers": [ [ "species_10608685", "catalyst" ] ], "additional_components": [ "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00006727", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10658943": { "compartment": "compartment_876", "id": "reaction_10658943", "reactome": "R-CEL-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608708", "species_10608658", "species_179856", "species_10608639" ], "products": [ "species_10658936" ], "modifiers": [], "additional_components": [ "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10661673": { "compartment": "compartment_70101", "id": "reaction_10661673", "reactome": "R-CEL-8951490", "name": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608733" ], "products": [ "species_10608683", "species_10608770" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10664920": { "compartment": "compartment_984", "id": "reaction_10664920", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10664916" ], "products": [ "species_10664918" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344", "WBGene00000039", "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q18581", "WBGene00000039", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344" ] }, "reaction_10664965": { "compartment": "compartment_984", "id": "reaction_10664965", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10648914", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "A0A1C3NSL8", "WBGene00017478" ] }, "reaction_10641650": { "compartment": "compartment_7660", "id": "reaction_10641650", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641629", "species_10638181" ], "products": [ "species_10641648", "species_10638173" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "P55853", "WBGene00004888", "WBGene00006706" ] }, "reaction_10604599": { "compartment": "compartment_7660", "id": "reaction_10604599", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604596" ], "products": [ "species_10604589", "species_110216" ], "modifiers": [ [ "species_10604596", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604615": { "compartment": "compartment_7660", "id": "reaction_10604615", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604612" ], "products": [ "species_10604605", "species_110225" ], "modifiers": [ [ "species_10604612", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604629": { "compartment": "compartment_7660", "id": "reaction_10604629", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604626" ], "products": [ "species_10604605", "species_5637659" ], "modifiers": [ [ "species_10604626", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604592": { "compartment": "compartment_7660", "id": "reaction_10604592", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604585" ], "products": [ "species_29554", "species_10604589" ], "modifiers": [ [ "species_10604585", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604718": { "compartment": "compartment_7660", "id": "reaction_10604718", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604707" ], "products": [ "species_10604715" ], "modifiers": [ [ "species_10604707", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10646034": { "compartment": "compartment_7660", "id": "reaction_10646034", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715" ], "products": [ "species_10646032" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10604608": { "compartment": "compartment_7660", "id": "reaction_10604608", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604603" ], "products": [ "species_10604605", "species_110223" ], "modifiers": [ [ "species_10604603", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604622": { "compartment": "compartment_7660", "id": "reaction_10604622", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604619" ], "products": [ "species_30140", "species_10604605" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10603043": { "compartment": "compartment_70101", "id": "reaction_10603043", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10649471": { "compartment": "compartment_12045", "id": "reaction_10649471", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10649468", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10623982": { "compartment": "compartment_70101", "id": "reaction_10623982", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10623979", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10654790": { "compartment": "compartment_12045", "id": "reaction_10654790", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10654787", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10603094": { "compartment": "compartment_70101", "id": "reaction_10603094", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10603087", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10603055": { "compartment": "compartment_70101", "id": "reaction_10603055", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10603052", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10603104": { "compartment": "compartment_70101", "id": "reaction_10603104", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10603101", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10620748": { "compartment": "compartment_70101", "id": "reaction_10620748", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620739", "species_10620744" ], "products": [ "species_10620746" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10622178": { "compartment": "compartment_70101", "id": "reaction_10622178", "reactome": "R-CEL-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622174", "species_10608499" ], "products": [ "species_10622176" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00016197", "O16785", "WBGene00003932", "Q09476", "WBGene00016197" ] }, "reaction_10620734": { "compartment": "compartment_70101", "id": "reaction_10620734", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620725", "species_10620730" ], "products": [ "species_10620732" ], "modifiers": [], "additional_components": [ "WBGene00000228", "WBGene00003932", "O16785", "WBGene00003932", "Q23158", "WBGene00000228" ] }, "reaction_10621028": { "compartment": "compartment_70101", "id": "reaction_10621028", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10620730" ], "products": [ "species_10621026" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10608576": { "compartment": "compartment_70101", "id": "reaction_10608576", "reactome": "R-CEL-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_29372", "species_10608574" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608461": { "compartment": "compartment_70101", "id": "reaction_10608461", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604177", "species_10602400" ], "products": [ "species_10608459" ], "modifiers": [], "additional_components": [ "WBGene00004928", "WBGene00004774", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608619": { "compartment": "compartment_70101", "id": "reaction_10608619", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10608459" ], "products": [ "species_10608549" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608535": { "compartment": "compartment_70101", "id": "reaction_10608535", "reactome": "R-CEL-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608497", "species_29356" ], "products": [ "species_10608503", "species_10608482", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "G5ECJ6", "WBGene00000812", "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "WBGene00000812", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608547": { "compartment": "compartment_70101", "id": "reaction_10608547", "reactome": "R-CEL-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_10608545", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608597": { "compartment": "compartment_70101", "id": "reaction_10608597", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10608594", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608599": { "compartment": "compartment_70101", "id": "reaction_10608599", "reactome": "R-CEL-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608551" ], "products": [ "species_10608553" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608559": { "compartment": "compartment_70101", "id": "reaction_10608559", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608553", "species_113592" ], "products": [ "species_29370", "species_10608530" ], "modifiers": [ [ "species_10608553", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10617088": { "compartment": "compartment_984", "id": "reaction_10617088", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617085" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_10615845", "species_114523" ], "modifiers": [ [ "species_10617085", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617033": { "compartment": "compartment_374932", "id": "reaction_10617033", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10617091": { "compartment": "compartment_876", "id": "reaction_10617091", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10617083", "species_10614053", "species_10614048" ], "products": [ "species_10617085" ], "modifiers": [ [ "species_10617083", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10619748": { "compartment": "compartment_876", "id": "reaction_10619748", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10619743", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_109496", "species_74113", "species_74016", "species_109496", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10617308": { "compartment": "compartment_70101", "id": "reaction_10617308", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617306" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617233", "catalyst" ], [ "species_10617202", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_111349", "Q18246", "WBGene00004307", "species_29438", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617235": { "compartment": "compartment_876", "id": "reaction_10617235", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617228": { "compartment": "compartment_12045", "id": "reaction_10617228", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617218" ], "products": [ "species_10617226" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10617204": { "compartment": "compartment_876", "id": "reaction_10617204", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617200", "species_30389" ], "products": [ "species_10617202" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617304": { "compartment": "compartment_876", "id": "reaction_10617304", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617302" ], "products": [ "species_10617302" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "WBGene00002189" ] }, "reaction_10601861": { "compartment": "compartment_7660", "id": "reaction_10601861", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601855" ], "products": [ "species_10601775", "species_10601859" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "P48322", "WBGene00007980", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "WBGene00007980", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749" ] }, "reaction_10601779": { "compartment": "compartment_7660", "id": "reaction_10601779", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601775", "species_10601770" ], "products": [ "species_10601777" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q9U3I0", "WBGene00009078", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q9U3I0", "WBGene00009078", "P48322", "WBGene00007980", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999" ] }, "reaction_10602569": { "compartment": "compartment_350", "id": "reaction_10602569", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10601859", "catalyst" ], [ "species_10602567", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "G5EET5", "WBGene00001995" ] }, "reaction_10637186": { "compartment": "compartment_876", "id": "reaction_10637186", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637182", "species_1297302" ], "products": [ "species_10637184" ], "modifiers": [], "additional_components": [ "WBGene00011923", "G5ECE8", "WBGene00011923", "species_1297302" ] }, "reaction_10637196": { "compartment": "compartment_876", "id": "reaction_10637196", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10637193", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10614415": { "compartment": "compartment_876", "id": "reaction_10614415", "reactome": "R-CEL-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614410" ], "products": [ "species_10608528", "species_10612190" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038" ] }, "reaction_10604456": { "compartment": "compartment_70101", "id": "reaction_10604456", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10602400" ], "products": [ "species_10602407" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10608588": { "compartment": "compartment_70101", "id": "reaction_10608588", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608585", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614408": { "compartment": "compartment_876", "id": "reaction_10614408", "reactome": "R-CEL-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10612156" ], "products": [ "species_10614406" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608477": { "compartment": "compartment_876", "id": "reaction_10608477", "reactome": "R-CEL-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608473" ], "products": [ "species_10608475" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608603": { "compartment": "compartment_70101", "id": "reaction_10608603", "reactome": "R-CEL-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10608528" ], "products": [ "species_10608585" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608581": { "compartment": "compartment_70101", "id": "reaction_10608581", "reactome": "R-CEL-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608578", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10665754": { "compartment": "compartment_459", "id": "reaction_10665754", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10665750" ], "products": [ "species_10665752" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10608566": { "compartment": "compartment_70101", "id": "reaction_10608566", "reactome": "R-CEL-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608475", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608612": { "compartment": "compartment_70101", "id": "reaction_10608612", "reactome": "R-CEL-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608609", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608601": { "compartment": "compartment_984", "id": "reaction_10608601", "reactome": "R-CEL-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10608471" ], "products": [ "species_10608473" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614413": { "compartment": "compartment_70101", "id": "reaction_10614413", "reactome": "R-CEL-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614406", "species_113592" ], "products": [ "species_29370", "species_10614410" ], "modifiers": [ [ "species_10614406", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10598294": { "compartment": "compartment_70101", "id": "reaction_10598294", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10598290" ], "products": [ "species_10598292" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10609629": { "compartment": "compartment_7660", "id": "reaction_10609629", "reactome": "R-CEL-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609624" ], "products": [ "species_113582", "species_10605292", "species_10598141" ], "modifiers": [ [ "species_10609624", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10609622": { "compartment": "compartment_7660", "id": "reaction_10609622", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598298" ], "products": [ "species_113582", "species_10598141" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10609626": { "compartment": "compartment_7660", "id": "reaction_10609626", "reactome": "R-CEL-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598311", "species_10598141" ], "products": [ "species_10609624" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10605940": { "compartment": "compartment_13231", "id": "reaction_10605940", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598292" ], "products": [ "species_10598298" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10638555": { "compartment": "compartment_70101", "id": "reaction_10638555", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10638551" ], "products": [ "species_10638553" ], "modifiers": [], "additional_components": [ "WBGene00003405", "Q23255", "WBGene00003405", "species_874088" ] }, "reaction_10645205": { "compartment": "compartment_876", "id": "reaction_10645205", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645197" ], "products": [ "species_29370", "species_10645203" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "WBGene00005077" ] }, "reaction_10644469": { "compartment": "compartment_876", "id": "reaction_10644469", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642488", "species_112275" ], "products": [ "species_10644467" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10653154": { "compartment": "compartment_6799713", "id": "reaction_10653154", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653046" ], "products": [ "species_10653152" ], "modifiers": [], "additional_components": [ "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064", "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064" ] }, "reaction_10644482": { "compartment": "compartment_876", "id": "reaction_10644482", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644480" ], "products": [ "species_10644471" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10625987": { "compartment": "compartment_70101", "id": "reaction_10625987", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625973" ], "products": [ "species_10625979", "species_10597908" ], "modifiers": [ [ "species_10625984", "catalyst" ] ], "additional_components": [ "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "WBGene00006727", "WBGene00009594" ] }, "reaction_10645210": { "compartment": "compartment_876", "id": "reaction_10645210", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645207" ], "products": [ "species_29370", "species_10645197" ], "modifiers": [ [ "species_10617744", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10657872": { "compartment": "compartment_876", "id": "reaction_10657872", "reactome": "R-CEL-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657866", "species_10657868" ], "products": [ "species_10657870" ], "modifiers": [], "additional_components": [ "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10661671": { "compartment": "compartment_876", "id": "reaction_10661671", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627143", "species_10627117" ], "products": [ "species_10627145" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10655607": { "compartment": "compartment_984", "id": "reaction_10655607", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10655569" ], "products": [ "species_10655571" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10612177": { "compartment": "compartment_70101", "id": "reaction_10612177", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846", "species_112275" ], "products": [ "species_10612175" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644478": { "compartment": "compartment_876", "id": "reaction_10644478", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644467" ], "products": [ "species_10644476" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644474": { "compartment": "compartment_876", "id": "reaction_10644474", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10644471", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10652445": { "compartment": "compartment_876", "id": "reaction_10652445", "reactome": "R-CEL-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652253" ], "products": [ "species_10652443" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421", "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421" ] }, "reaction_10612154": { "compartment": "compartment_70101", "id": "reaction_10612154", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_202277" ], "products": [ "species_10612152" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655611": { "compartment": "compartment_984", "id": "reaction_10655611", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655569", "species_6789198" ], "products": [ "species_10655609" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "species_6789198" ] }, "reaction_10635413": { "compartment": "compartment_876", "id": "reaction_10635413", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10653778": { "compartment": "compartment_6799371", "id": "reaction_10653778", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653746" ], "products": [ "species_10653776" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q18825", "WBGene00000238", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O01824", "WBGene00019008", "O44131", "WBGene00015620", "G5EGP8", "WBGene00000788", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "Q18825", "WBGene00000238", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "G5EGP8", "WBGene00000788" ] }, "reaction_10655577": { "compartment": "compartment_984", "id": "reaction_10655577", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655571" ], "products": [ "species_10655575" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10657844": { "compartment": "compartment_984", "id": "reaction_10657844", "reactome": "R-CEL-8852716", "name": "Thrombin, ELANE cleave C5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607933" ], "products": [ "species_10607947", "species_10657842" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10656550": { "compartment": "compartment_984", "id": "reaction_10656550", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10656546" ], "products": [ "species_10656548" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "species_166005", "O44131", "WBGene00015620" ] }, "reaction_10653606": { "compartment": "compartment_1462052", "id": "reaction_10653606", "reactome": "R-CEL-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653432" ], "products": [ "species_10653604" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760" ] }, "reaction_10628353": { "compartment": "compartment_876", "id": "reaction_10628353", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627119", "species_10627117" ], "products": [ "species_10627121" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10654208": { "compartment": "compartment_1470028", "id": "reaction_10654208", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654040" ], "products": [ "species_10654206" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837", "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837" ] }, "reaction_10627062": { "compartment": "compartment_984", "id": "reaction_10627062", "reactome": "R-CEL-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627056", "species_10627058" ], "products": [ "species_10627060" ], "modifiers": [], "additional_components": [ "WBGene00006619", "WBGene00006619", "Q23528", "WBGene00006619" ] }, "reaction_10637568": { "compartment": "compartment_876", "id": "reaction_10637568", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637562" ], "products": [ "species_29370", "species_10637565" ], "modifiers": [ [ "species_10637562", "catalyst" ] ], "additional_components": [ "WBGene00005077", "WBGene00005077", "WBGene00005077" ] }, "reaction_10663891": { "compartment": "compartment_70101", "id": "reaction_10663891", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638461", "species_8982080" ], "products": [ "species_10663889" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10635404": { "compartment": "compartment_876", "id": "reaction_10635404", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10635401", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256", "G5EDU3", "WBGene00004040" ] }, "reaction_10657864": { "compartment": "compartment_984", "id": "reaction_10657864", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657846" ], "products": [ "species_10657848" ], "modifiers": [ [ "species_10657861", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q9N5D7", "WBGene00020693", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593" ] }, "reaction_10637988": { "compartment": "compartment_984", "id": "reaction_10637988", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607167" ], "products": [ "species_10627129" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10645212": { "compartment": "compartment_876", "id": "reaction_10645212", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10607837" ], "products": [ "species_10645207" ], "modifiers": [], "additional_components": [ "WBGene00003030", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10655475": { "compartment": "compartment_984", "id": "reaction_10655475", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655427" ], "products": [ "species_10655473" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788" ] }, "reaction_10610934": { "compartment": "compartment_876", "id": "reaction_10610934", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610919" ], "products": [ "species_29370", "species_10610931" ], "modifiers": [ [ "species_10610919", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10637560": { "compartment": "compartment_70101", "id": "reaction_10637560", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10637558" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10607959": { "compartment": "compartment_984", "id": "reaction_10607959", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607181" ], "products": [ "species_10607957" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627220": { "compartment": "compartment_876", "id": "reaction_10627220", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607189" ], "products": [ "species_10627119" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627236": { "compartment": "compartment_876", "id": "reaction_10627236", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607167" ], "products": [ "species_10627143" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627155": { "compartment": "compartment_876", "id": "reaction_10627155", "reactome": "R-CEL-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627060", "species_10627151" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627210": { "compartment": "compartment_876", "id": "reaction_10627210", "reactome": "R-CEL-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_10627185", "species_10627060", "species_10627183", "species_10627207" ], "modifiers": [ [ "species_10627153", "catalyst" ] ], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q22328", "WBGene00002976", "Q23528", "WBGene00006619", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10652817": { "compartment": "compartment_6800173", "id": "reaction_10652817", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652705" ], "products": [ "species_10652815" ], "modifiers": [], "additional_components": [ "Q4W5T6", "WBGene00044310", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760", "Q4W5T6", "WBGene00044310", "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760" ] }, "reaction_10635284": { "compartment": "compartment_70101", "id": "reaction_10635284", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635282", "species_113592" ], "products": [ "species_29370", "species_10618297", "species_10617721" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10655079": { "compartment": "compartment_6800424", "id": "reaction_10655079", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655055" ], "products": [ "species_10655077" ], "modifiers": [], "additional_components": [ "Q20684", "WBGene00002265", "Q9U308", "WBGene00002175", "Q20665", "WBGene00255469", "G5EC10", "WBGene00002272", "Q9N4W4", "WBGene00021602", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q19930", "WBGene00017947", "Q22799", "WBGene00001005", "Q9GYK0", "WBGene00015471", "P30628", "WBGene00006768", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "G5EBV4", "WBGene00002273", "Q9XTY9", "WBGene00010993", "Q9XUF4", "WBGene00008203", "Q19833", "WBGene00017837", "G5EDC6", "WBGene00000192", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q17540", "WBGene00015283", "Q21146", "WBGene00019328", "Q53U87", "WBGene00004732", "G5ED34", "WBGene00001007", "O44873", "WBGene00019915", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "Q9N5X7", "WBGene00016423", "G5EFI4", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10607104" ], "products": [ "species_10655831" ], "modifiers": [], "additional_components": [ "WBGene00022627", "species_166005", "Q23365", "WBGene00022627" ] }, "reaction_10654694": { "compartment": "compartment_6799351", "id": "reaction_10654694", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00006633", "P34462", "WBGene00010130", "Q95QY6", "WBGene00022014", "Q95XH1", "WBGene00022077", "P34446", "WBGene00003929", "Q9NCE1", "WBGene00010408", "G5EBK2", "WBGene00014084", "Q22908", "WBGene00016344", "O44186", "WBGene00017996", "G5EC93", "WBGene00022014", "Q21228", "WBGene00018527", "Q19878", "WBGene00009218", "O44616", "WBGene00022014", "Q20707", "WBGene00006630", "Q19983", "WBGene00006634", "Q93323", "WBGene00007903", "O45920", "WBGene00022014", "Q5WRN9", "WBGene00023502", "P83386", "WBGene00018527", "Q9XVM9", "WBGene00006641", "G5EGM1", "WBGene00006987", "G5EC63", "WBGene00013197", "Q1ZXU1", "WBGene00044790", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "G5EFD9", "WBGene00006324", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q23535", "WBGene00006865", "A0A4V0IKG6", "WBGene00007287", "O62466", "WBGene00006631", "Q11114", "WBGene00022014", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491" ] }, "reaction_10639131": { "compartment": "compartment_876", "id": "reaction_10639131", "reactome": "R-CEL-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639108" ], "products": [ "species_10627115", "species_10639128", "species_10639122" ], "modifiers": [ [ "species_10627060", "catalyst" ] ], "additional_components": [ "Q18849", "WBGene00008314", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619" ] }, "reaction_10651831": { "compartment": "compartment_6798757", "id": "reaction_10651831", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651701" ], "products": [ "species_10651829" ], "modifiers": [], "additional_components": [ "P45971", "WBGene00011638", "E5QCE7", "WBGene00001032", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q18276", "WBGene00004995", "X5LV99", "WBGene00019346", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421", "E5QCE7", "WBGene00001032", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "X5LV99", "WBGene00019346", "Q18276", "WBGene00004995", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421" ] }, "reaction_10665782": { "compartment": "compartment_70101", "id": "reaction_10665782", "reactome": "R-CEL-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10607014" ], "products": [ "species_10665780" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "O45418", "WBGene00001431", "species_9678991", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10629435": { "compartment": "compartment_876", "id": "reaction_10629435", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629432", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10629464": { "compartment": "compartment_876", "id": "reaction_10629464", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629461", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10610716": { "compartment": "compartment_876", "id": "reaction_10610716", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609937", "species_10609928" ], "products": [ "species_10609939" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10610718": { "compartment": "compartment_876", "id": "reaction_10610718", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609921", "species_10609926" ], "products": [ "species_10609928" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "P10984", "WBGene00000064", "WBGene00000894", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10666007": { "compartment": "compartment_7660", "id": "reaction_10666007", "reactome": "R-CEL-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10666001" ], "products": [ "species_10665989", "species_427486" ], "modifiers": [ [ "species_10628319", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00001834" ] }, "reaction_10666004": { "compartment": "compartment_70101", "id": "reaction_10666004", "reactome": "R-CEL-9701531", "name": "p-Y705,S727 STAT3 is acetylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10665989" ], "products": [ "species_2485002", "species_10666001" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00000366" ] }, "reaction_10623765": { "compartment": "compartment_876", "id": "reaction_10623765", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623760": { "compartment": "compartment_876", "id": "reaction_10623760", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10621827": { "compartment": "compartment_876", "id": "reaction_10621827", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10621824", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623751": { "compartment": "compartment_876", "id": "reaction_10623751", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623756": { "compartment": "compartment_876", "id": "reaction_10623756", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623767": { "compartment": "compartment_876", "id": "reaction_10623767", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623758": { "compartment": "compartment_876", "id": "reaction_10623758", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10643263": { "compartment": "compartment_70101", "id": "reaction_10643263", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10643259" ], "products": [ "species_10643261" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10663022": { "compartment": "compartment_70101", "id": "reaction_10663022", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663018" ], "products": [ "species_29368", "species_10663016" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185" ] }, "reaction_10663249": { "compartment": "compartment_70101", "id": "reaction_10663249", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643261" ], "products": [ "species_29368", "species_10643259" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185" ] }, "reaction_10663020": { "compartment": "compartment_70101", "id": "reaction_10663020", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10663016" ], "products": [ "species_10663018" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185" ] }, "reaction_10619462": { "compartment": "compartment_876", "id": "reaction_10619462", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_111627" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10619459", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619469": { "compartment": "compartment_876", "id": "reaction_10619469", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_352022", "species_425425", "species_74113" ], "products": [ "species_83910", "species_351626", "species_111627", "species_188972" ], "modifiers": [ [ "species_10619464", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619454": { "compartment": "compartment_876", "id": "reaction_10619454", "reactome": "R-CEL-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10619447", "catalyst" ] ], "additional_components": [ "WBGene00019844" ] }, "reaction_10647253": { "compartment": "compartment_70101", "id": "reaction_10647253", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647189" ], "products": [ "species_10647227", "species_29372" ], "modifiers": [ [ "species_10647250", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10038", "WBGene00006923", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10605081": { "compartment": "compartment_70101", "id": "reaction_10605081", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605072" ], "products": [ "species_29370", "species_10604506" ], "modifiers": [ [ "species_10605078", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10647195": { "compartment": "compartment_7660", "id": "reaction_10647195", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647189" ], "products": [ "species_10647193" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10604479": { "compartment": "compartment_70101", "id": "reaction_10604479", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604463", "species_10604475" ], "products": [ "species_10604477" ], "modifiers": [], "additional_components": [ "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665" ] }, "reaction_10604510": { "compartment": "compartment_70101", "id": "reaction_10604510", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604477" ], "products": [ "species_29370", "species_10604501" ], "modifiers": [ [ "species_10604477", "catalyst" ], [ "species_10604506", "inhibitor" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186" ] }, "reaction_10604522": { "compartment": "compartment_70101", "id": "reaction_10604522", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604501" ], "products": [ "species_10604463", "species_10604499" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10638746": { "compartment": "compartment_70101", "id": "reaction_10638746", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622515" ], "products": [ "species_29370", "species_10622458" ], "modifiers": [ [ "species_10638729", "catalyst" ] ], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "WBGene00003822" ] }, "reaction_10638836": { "compartment": "compartment_7660", "id": "reaction_10638836", "reactome": "R-CEL-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638821", "species_29358" ], "products": [ "species_113582", "species_10638833" ], "modifiers": [ [ "species_10638821", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10662912": { "compartment": "compartment_7660", "id": "reaction_10662912", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10638719" ], "products": [ "species_10638721" ], "modifiers": [], "additional_components": [ "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638742": { "compartment": "compartment_70101", "id": "reaction_10638742", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638731", "species_1250243" ], "products": [ "species_10638729", "species_10601705" ], "modifiers": [ [ "species_10638736", "catalyst" ] ], "additional_components": [ "O45017", "WBGene00020917", "Q21029", "WBGene00003822", "WBGene00003822", "WBGene00020917", "WBGene00003247" ] }, "reaction_10638724": { "compartment": "compartment_7660", "id": "reaction_10638724", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10638705" ], "products": [ "species_159939", "species_10638707" ], "modifiers": [ [ "species_10638721", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638823": { "compartment": "compartment_7660", "id": "reaction_10638823", "reactome": "R-CEL-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638819" ], "products": [ "species_113582", "species_10638821" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10638839": { "compartment": "compartment_7660", "id": "reaction_10638839", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638707", "species_77087" ], "products": [ "species_77502", "species_10638705" ], "modifiers": [ [ "species_10614316", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036" ] }, "reaction_10621550": { "compartment": "compartment_70101", "id": "reaction_10621550", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615234" ], "products": [ "species_10621548" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00005077", "G5EE56", "WBGene00005077", "Q07292", "WBGene00003030" ] }, "reaction_10621571": { "compartment": "compartment_70101", "id": "reaction_10621571", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10621567" ], "products": [ "species_10621569" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10613690": { "compartment": "compartment_70101", "id": "reaction_10613690", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10613687", "catalyst" ] ], "additional_components": [ "species_113531", "G5EED8", "WBGene00006600" ] }, "reaction_10613711": { "compartment": "compartment_70101", "id": "reaction_10613711", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10597831": { "compartment": "compartment_7660", "id": "reaction_10597831", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597827", "species_10597822" ], "products": [ "species_10597829" ], "modifiers": [], "additional_components": [ "WBGene00012935", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158" ] }, "reaction_10630180": { "compartment": "compartment_7660", "id": "reaction_10630180", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10630172" ], "products": [ "species_113582", "species_10630164" ], "modifiers": [ [ "species_10630177", "catalyst" ] ], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10630243": { "compartment": "compartment_7660", "id": "reaction_10630243", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628748" ], "products": [ "species_10630241" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597751": { "compartment": "compartment_7660", "id": "reaction_10597751", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597742", "species_10597721" ], "products": [ "species_10597744" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10605320": { "compartment": "compartment_7660", "id": "reaction_10605320", "reactome": "R-CEL-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10605292" ], "products": [ "species_113550", "species_10605294" ], "modifiers": [ [ "species_10605317", "catalyst" ] ], "additional_components": [ "WBGene00003020", "G5EDT1", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10605322": { "compartment": "compartment_7660", "id": "reaction_10605322", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113" ], "products": [ "species_113656", "species_10597721" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10628796": { "compartment": "compartment_7660", "id": "reaction_10628796", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10628319" ], "products": [ "species_10628794" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "WBGene00001834", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10597837": { "compartment": "compartment_7660", "id": "reaction_10597837", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597829" ], "products": [ "species_10597780", "species_10597835" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00000413", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10630247": { "compartment": "compartment_7660", "id": "reaction_10630247", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628784" ], "products": [ "species_10630245" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10628800": { "compartment": "compartment_7660", "id": "reaction_10628800", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628319", "species_10628784" ], "products": [ "species_10628798" ], "modifiers": [], "additional_components": [ "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10598120": { "compartment": "compartment_7660", "id": "reaction_10598120", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597740", "species_68419" ], "products": [ "species_10597742" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823" ] }, "reaction_10630168": { "compartment": "compartment_7660", "id": "reaction_10630168", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630164", "species_10628773" ], "products": [ "species_10630166" ], "modifiers": [], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "G5EDT1", "WBGene00003020", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10630251": { "compartment": "compartment_7660", "id": "reaction_10630251", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628782" ], "products": [ "species_10630249" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10630239": { "compartment": "compartment_7660", "id": "reaction_10630239", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10630235" ], "products": [ "species_10630237" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10638114": { "compartment": "compartment_7660", "id": "reaction_10638114", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638089" ], "products": [ "species_10638074" ], "modifiers": [ [ "species_10638111", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10641285": { "compartment": "compartment_7660", "id": "reaction_10641285", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10602463" ], "products": [ "species_10641283", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "P62784", "WBGene00001875", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641349": { "compartment": "compartment_7660", "id": "reaction_10641349", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628319" ], "products": [ "species_10638173", "species_10641347" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "WBGene00006706", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641371": { "compartment": "compartment_7660", "id": "reaction_10641371", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628321" ], "products": [ "species_10641369", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641338": { "compartment": "compartment_7660", "id": "reaction_10641338", "reactome": "R-CEL-4615872", "name": "RANBP2 SUMOylates HDAC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641328", "species_10638181" ], "products": [ "species_10638173", "species_10641336" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00001837", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "P55853", "WBGene00004888", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10662809": { "compartment": "compartment_7660", "id": "reaction_10662809", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640202", "species_10638181" ], "products": [ "species_10662801", "species_10638173" ], "modifiers": [ [ "species_10662806", "catalyst" ] ], "additional_components": [ "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "WBGene00006706", "WBGene00010704" ] }, "reaction_10604149": { "compartment": "compartment_70101", "id": "reaction_10604149", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_83910", "species_179743" ], "modifiers": [ [ "species_10604146", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10665056": { "compartment": "compartment_876", "id": "reaction_10665056", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10624695": { "compartment": "compartment_20699", "id": "reaction_10624695", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10624692", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10604142": { "compartment": "compartment_70101", "id": "reaction_10604142", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10610539": { "compartment": "compartment_876", "id": "reaction_10610539", "reactome": "R-CEL-194130", "name": "Transport (influx) of bile salts and acids by OATP-A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192483" ], "products": [ "species_194156" ], "modifiers": [ [ "species_10610536", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10610509": { "compartment": "compartment_876", "id": "reaction_10610509", "reactome": "R-CEL-194079", "name": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10606540": { "compartment": "compartment_70616", "id": "reaction_10606540", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10606537", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10625070": { "compartment": "compartment_876", "id": "reaction_10625070", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10625067", "catalyst" ] ], "additional_components": [ "CHEBI:63836", "species_176496", "species_176501", "CHEBI:63836", "species_176496", "species_176501", "WBGene00018566" ] }, "reaction_10610520": { "compartment": "compartment_876", "id": "reaction_10610520", "reactome": "R-CEL-194083", "name": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10625124": { "compartment": "compartment_876", "id": "reaction_10625124", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10625121", "catalyst" ] ], "additional_components": [ "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346", "Q9XWC5", "WBGene00013499" ] }, "reaction_10625088": { "compartment": "compartment_876", "id": "reaction_10625088", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10625085", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q9XWC5", "WBGene00013499" ] }, "reaction_10604129": { "compartment": "compartment_70101", "id": "reaction_10604129", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10604154": { "compartment": "compartment_70101", "id": "reaction_10604154", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10604131": { "compartment": "compartment_70101", "id": "reaction_10604131", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10625107": { "compartment": "compartment_876", "id": "reaction_10625107", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10625104", "catalyst" ] ], "additional_components": [ "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10624687": { "compartment": "compartment_70101", "id": "reaction_10624687", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10624684", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10604139": { "compartment": "compartment_70101", "id": "reaction_10604139", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_179738" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10604136", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "WBGene00017867" ] }, "reaction_10625065": { "compartment": "compartment_876", "id": "reaction_10625065", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10625062", "catalyst" ] ], "additional_components": [ "CHEBI:15544", "species_879535", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "species_879629", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10604144": { "compartment": "compartment_70101", "id": "reaction_10604144", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10661501": { "compartment": "compartment_70101", "id": "reaction_10661501", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655821" ], "modifiers": [ [ "species_10661496", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00002278" ] }, "reaction_10661452": { "compartment": "compartment_70101", "id": "reaction_10661452", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661444" ], "products": [ "species_29370", "species_10661449" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10655808": { "compartment": "compartment_7660", "id": "reaction_10655808", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655802" ], "products": [ "species_10611220" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611223": { "compartment": "compartment_70101", "id": "reaction_10611223", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10655829": { "compartment": "compartment_70101", "id": "reaction_10655829", "reactome": "R-CEL-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655821", "species_29356" ], "products": [ "species_10611220", "species_10597908" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00001112" ] }, "reaction_10661506": { "compartment": "compartment_70101", "id": "reaction_10661506", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661503", "species_10597908" ], "products": [ "species_10657634" ], "modifiers": [ [ "species_10639898", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10661454": { "compartment": "compartment_13231", "id": "reaction_10661454", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661444" ], "products": [ "species_10661442" ], "modifiers": [ [ "species_10606957", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10636497": { "compartment": "compartment_70101", "id": "reaction_10636497", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10612150" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10611215": { "compartment": "compartment_876", "id": "reaction_10611215", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611003", "species_10610986" ], "products": [ "species_10611005" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10661299": { "compartment": "compartment_7660", "id": "reaction_10661299", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640221", "species_10661293" ], "products": [ "species_10661297" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773" ] }, "reaction_10657264": { "compartment": "compartment_70101", "id": "reaction_10657264", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10657260" ], "products": [ "species_10657262" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10636439": { "compartment": "compartment_70101", "id": "reaction_10636439", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_179856" ], "products": [ "species_10636437" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10636520": { "compartment": "compartment_876", "id": "reaction_10636520", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610889", "species_10604443" ], "products": [ "species_10610891" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10657270": { "compartment": "compartment_70101", "id": "reaction_10657270", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10657262" ], "products": [ "species_29370", "species_10657267", "species_10657260" ], "modifiers": [ [ "species_10657262", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10655800": { "compartment": "compartment_70101", "id": "reaction_10655800", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655794" ], "products": [ "species_10655798" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611007": { "compartment": "compartment_70101", "id": "reaction_10611007", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610986" ], "products": [ "species_29370", "species_10610889" ], "modifiers": [ [ "species_10611000", "catalyst" ], [ "species_10611005", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10657638": { "compartment": "compartment_70101", "id": "reaction_10657638", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657636" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10655818": { "compartment": "compartment_70101", "id": "reaction_10655818", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655811" ], "modifiers": [ [ "species_10655815", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "G5ECY6", "WBGene00000500" ] }, "reaction_10636522": { "compartment": "compartment_70101", "id": "reaction_10636522", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838" ], "products": [ "species_10610986" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10655805": { "compartment": "compartment_7660", "id": "reaction_10655805", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10655798" ], "products": [ "species_10655802", "species_10597874" ], "modifiers": [ [ "species_10648336", "catalyst" ], [ "species_10638301", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00010406", "WBGene00003599" ] }, "reaction_10610912": { "compartment": "compartment_70101", "id": "reaction_10610912", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610891" ], "products": [ "species_29370", "species_10610909", "species_10604443" ], "modifiers": [ [ "species_10610891", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10661311": { "compartment": "compartment_7660", "id": "reaction_10661311", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661303", "species_10661305" ], "products": [ "species_10661309" ], "modifiers": [], "additional_components": [ "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207" ] }, "reaction_10657626": { "compartment": "compartment_70101", "id": "reaction_10657626", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611220" ], "products": [ "species_29370", "species_10657624" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10599349": { "compartment": "compartment_70101", "id": "reaction_10599349", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10599346", "catalyst" ] ], "additional_components": [ "Q9Y041", "WBGene00001843", "species_113531" ] }, "reaction_10599320": { "compartment": "compartment_70101", "id": "reaction_10599320", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10599317", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10599339": { "compartment": "compartment_70101", "id": "reaction_10599339", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10599336", "catalyst" ] ], "additional_components": [ "Q22633", "WBGene00001993", "Q18347", "WBGene00016294", "species_113531", "species_198836" ] }, "reaction_10599369": { "compartment": "compartment_70101", "id": "reaction_10599369", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10599366", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10599359": { "compartment": "compartment_70101", "id": "reaction_10599359", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10599356", "catalyst" ] ], "additional_components": [ "species_29450", "Q18938", "WBGene00001790" ] }, "reaction_10630983": { "compartment": "compartment_70616", "id": "reaction_10630983", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524079", "species_1524072" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10631012": { "compartment": "compartment_12045", "id": "reaction_10631012", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10631010": { "compartment": "compartment_12045", "id": "reaction_10631010", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524069", "species_1500578" ], "products": [ "species_76194", "species_1524081" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10630999": { "compartment": "compartment_70616", "id": "reaction_10630999", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524083" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10630972": { "compartment": "compartment_70616", "id": "reaction_10630972", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_29374", "species_1524072" ], "modifiers": [ [ "species_10630969", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10666115": { "compartment": "compartment_876", "id": "reaction_10666115", "reactome": "R-CEL-9712210", "name": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666095", "species_10666101", "species_9712200" ], "products": [ "species_10666113" ], "modifiers": [], "additional_components": [ "WBGene00001052", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "CHEBI:28837", "CHEBI:16424", "CHEBI:17580", "CHEBI:30772", "pubchem.compound:17356", "CHEBI:86192", "CHEBI:15409", "CHEBI:16731", "CHEBI:45571", "CHEBI:4917", "CHEBI:4918", "species_427486", "pubchem.compound:17072", "CHEBI:36740", "CHEBI:15400", "CHEBI:168721", "CHEBI:5331", "CHEBI:17362", "CHEBI:29452", "CHEBI:30065", "CHEBI:168585", "CHEBI:171895", "CHEBI:28591", "pubchem.compound:228987", "CHEBI:48408", "CHEBI:17447", "pubchem.compound:101330", "species_76328", "CHEBI:61727", "pubchem.compound:8144", "pubchem.compound:181287", "CHEBI:30776", "CHEBI:87362", "pubchem.compound:20499", "pubchem.compound:91604", "CHEBI:37894", "species_6807616", "CHEBI:15399", "pubchem.compound:92979", "pubchem.compound:106997", "CHEBI:28235", "CHEBI:18346", "CHEBI:76306", "CHEBI:34522", "pubchem.compound:61052", "CHEBI:46202", "CHEBI:18224", "CHEBI:30768", "CHEBI:28600", "CHEBI:28484", "CHEBI:30805", "CHEBI:34037", "CHEBI:28857", "CHEBI:67890", "pubchem.compound:64805", "CHEBI:167345", "CHEBI:28878", "CHEBI:89886", "species_29420", "P17343", "WBGene00001679", "CHEBI:4917", "G5ECT6", "WBGene00001682", "Q86ME6", "WBGene00001052", "CHEBI:167345", "V6CLB7", "WBGene00020997", "pubchem.compound:91604", "CHEBI:5331", "CHEBI:16731", "Q7KPV0", "WBGene00001745", "CHEBI:28484" ] }, "reaction_10661541": { "compartment": "compartment_70616", "id": "reaction_10661541", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606780" ], "products": [ "species_10661539" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10623825": { "compartment": "compartment_70101", "id": "reaction_10623825", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10623822", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10622101": { "compartment": "compartment_70101", "id": "reaction_10622101", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10622098", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10650271": { "compartment": "compartment_70101", "id": "reaction_10650271", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10650268", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10655667": { "compartment": "compartment_70101", "id": "reaction_10655667", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6803785" ], "products": [ "species_70106", "species_29370", "species_6803738" ], "modifiers": [ [ "species_10655664", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_6803743", "species_449703", "Q23196", "WBGene00021056" ] }, "reaction_10650281": { "compartment": "compartment_70101", "id": "reaction_10650281", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10641130": { "compartment": "compartment_12045", "id": "reaction_10641130", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10641127", "catalyst" ] ], "additional_components": [ "Q20118", "WBGene00009505", "Q5FC21", "WBGene00044025" ] }, "reaction_10655675": { "compartment": "compartment_70101", "id": "reaction_10655675", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803743", "species_29356" ], "products": [ "species_449701", "species_193473" ], "modifiers": [ [ "species_10655672", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10650263": { "compartment": "compartment_70101", "id": "reaction_10650263", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10650260", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10650289": { "compartment": "compartment_70101", "id": "reaction_10650289", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10650286", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10622051": { "compartment": "compartment_70101", "id": "reaction_10622051", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10622048", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10622373": { "compartment": "compartment_70101", "id": "reaction_10622373", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10622370", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10641138": { "compartment": "compartment_12045", "id": "reaction_10641138", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10622363": { "compartment": "compartment_70101", "id": "reaction_10622363", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10622360", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10622119": { "compartment": "compartment_70101", "id": "reaction_10622119", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10622116", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10620242": { "compartment": "compartment_17938", "id": "reaction_10620242", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10620239", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10650292": { "compartment": "compartment_70101", "id": "reaction_10650292", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10648046": { "compartment": "compartment_7660", "id": "reaction_10648046", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648040" ], "products": [ "species_113582", "species_10648043" ], "modifiers": [ [ "species_10608272", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10625164": { "compartment": "compartment_5460", "id": "reaction_10625164", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625161", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10663595": { "compartment": "compartment_70101", "id": "reaction_10663595", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10642260", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10599553": { "compartment": "compartment_5460", "id": "reaction_10599553", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10599550", "catalyst" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596" ] }, "reaction_10598689": { "compartment": "compartment_70101", "id": "reaction_10598689", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29398" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10599144": { "compartment": "compartment_5460", "id": "reaction_10599144", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29362", "species_113587", "species_113529" ], "modifiers": [ [ "species_10599141", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10655838": { "compartment": "compartment_5460", "id": "reaction_10655838", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113557", "species_113529" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10655835", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10663592": { "compartment": "compartment_5460", "id": "reaction_10663592", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10663589", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10625174": { "compartment": "compartment_70616", "id": "reaction_10625174", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625171", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10622718": { "compartment": "compartment_5462", "id": "reaction_10622718", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10622715", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10599198": { "compartment": "compartment_5460", "id": "reaction_10599198", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10599195", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10612583": { "compartment": "compartment_5460", "id": "reaction_10612583", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599550", "species_113593" ], "products": [ "species_113581", "species_10612567" ], "modifiers": [ [ "species_10612572", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_10612581", "inhibitor" ], [ "species_113557", "inhibitor" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10599555": { "compartment": "compartment_5460", "id": "reaction_10599555", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10649888": { "compartment": "compartment_70101", "id": "reaction_10649888", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10649885", "catalyst" ] ], "additional_components": [ "species_216667", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10615570": { "compartment": "compartment_70101", "id": "reaction_10615570", "reactome": "R-CEL-373875", "name": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29708" ], "products": [ "species_373863", "species_351626" ], "modifiers": [ [ "species_10612981", "catalyst" ] ], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10599832": { "compartment": "compartment_5460", "id": "reaction_10599832", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10599829", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10622720": { "compartment": "compartment_5460", "id": "reaction_10622720", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10599121", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10622730": { "compartment": "compartment_5460", "id": "reaction_10622730", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113600", "species_29376", "species_113529" ], "modifiers": [ [ "species_10622727", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10599154": { "compartment": "compartment_5460", "id": "reaction_10599154", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113588" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10599151", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10625156": { "compartment": "compartment_5460", "id": "reaction_10625156", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10625153", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10663519": { "compartment": "compartment_5460", "id": "reaction_10663519", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612574", "species_9010792" ], "products": [ "species_10612581" ], "modifiers": [], "additional_components": [ "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10663554": { "compartment": "compartment_5460", "id": "reaction_10663554", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10663551", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_109496" ] }, "reaction_10599183": { "compartment": "compartment_5460", "id": "reaction_10599183", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10599180", "catalyst" ] ], "additional_components": [ "Q09508", "WBGene00015391", "O62215", "WBGene00009353", "P41956", "WBGene00003225", "Q09545", "WBGene00006433", "species_113596" ] }, "reaction_10599134": { "compartment": "compartment_5460", "id": "reaction_10599134", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10599131", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10599116": { "compartment": "compartment_5460", "id": "reaction_10599116", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599113", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q93353", "WBGene00007993", "Q20049", "WBGene00009440", "Q93714", "WBGene00009664", "species_266099" ] }, "reaction_10663526": { "compartment": "compartment_5460", "id": "reaction_10663526", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10663523", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10663568": { "compartment": "compartment_70101", "id": "reaction_10663568", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10663565", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10599872": { "compartment": "compartment_70101", "id": "reaction_10599872", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29398" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10629160": { "compartment": "compartment_70101", "id": "reaction_10629160", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353106", "species_29372" ], "products": [ "species_83951", "species_1237165" ], "modifiers": [ [ "species_10629157", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10629140": { "compartment": "compartment_70101", "id": "reaction_10629140", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10629137", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10630115": { "compartment": "compartment_70101", "id": "reaction_10630115", "reactome": "R-CEL-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10629127", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10629150": { "compartment": "compartment_70101", "id": "reaction_10629150", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10629147", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_109496" ] }, "reaction_10607469": { "compartment": "compartment_70616", "id": "reaction_10607469", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10607114", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29420", "species_29370", "species_113592", "species_29438" ] }, "reaction_10607123": { "compartment": "compartment_70616", "id": "reaction_10607123", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607114", "species_166213" ], "products": [ "species_10607116" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10607125": { "compartment": "compartment_70616", "id": "reaction_10607125", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607118" ], "products": [ "species_10607114", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10607121": { "compartment": "compartment_70616", "id": "reaction_10607121", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607116" ], "products": [ "species_10607118" ], "modifiers": [ [ "species_10607116", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10660441": { "compartment": "compartment_7660", "id": "reaction_10660441", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607861", "species_10658641" ], "products": [ "species_10660439" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "WBGene00004393", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393", "P45897", "WBGene00004858" ] }, "reaction_10660437": { "compartment": "compartment_7660", "id": "reaction_10660437", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660433", "species_10658641" ], "products": [ "species_10660435" ], "modifiers": [], "additional_components": [ "WBGene00022518", "WBGene00004393", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393" ] }, "reaction_10648407": { "compartment": "compartment_17951", "id": "reaction_10648407", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_5690520" ], "products": [ "species_193514", "species_5690539" ], "modifiers": [ [ "species_10648404", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10617868": { "compartment": "compartment_17947", "id": "reaction_10617868", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10617695": { "compartment": "compartment_17951", "id": "reaction_10617695", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_389596", "species_389573" ], "products": [ "species_389620", "species_389593", "species_389615" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617827": { "compartment": "compartment_17951", "id": "reaction_10617827", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10617818": { "compartment": "compartment_17951", "id": "reaction_10617818", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10656361": { "compartment": "compartment_17951", "id": "reaction_10656361", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617816": { "compartment": "compartment_17951", "id": "reaction_10617816", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10657324": { "compartment": "compartment_17947", "id": "reaction_10657324", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657320", "species_5690520" ], "products": [ "species_10657322" ], "modifiers": [], "additional_components": [ "Q20507", "WBGene00009818", "Q9XTZ5", "WBGene00007680", "Q20862", "WBGene00018949", "species_164991", "species_5690542", "Q20507", "WBGene00009818", "species_164991", "Q9XTZ5", "WBGene00007680", "species_5690542", "Q20862", "WBGene00018949" ] }, "reaction_10617708": { "compartment": "compartment_17951", "id": "reaction_10617708", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10617705", "catalyst" ] ], "additional_components": [ "species_113531", "O62515", "WBGene00014000" ] }, "reaction_10617674": { "compartment": "compartment_17951", "id": "reaction_10617674", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10617671", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10627078": { "compartment": "compartment_17951", "id": "reaction_10627078", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10627075", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10656358": { "compartment": "compartment_17951", "id": "reaction_10656358", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617698": { "compartment": "compartment_17951", "id": "reaction_10617698", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_6811612", "species_389573" ], "products": [ "species_389569", "species_389620", "species_389593" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617686": { "compartment": "compartment_17951", "id": "reaction_10617686", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10617683", "catalyst" ] ], "additional_components": [ "species_8878387", "Q17474", "WBGene00007143", "species_109496" ] }, "reaction_10650299": { "compartment": "compartment_17951", "id": "reaction_10650299", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10650296", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10656540": { "compartment": "compartment_17951", "id": "reaction_10656540", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10656537", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10613435": { "compartment": "compartment_70101", "id": "reaction_10613435", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331" ], "products": [ "species_10613333", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "Q03206", "ced-10", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10613439": { "compartment": "compartment_70101", "id": "reaction_10613439", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10613333", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10610461": { "compartment": "compartment_13231", "id": "reaction_10610461", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607331" ], "products": [ "species_10607264" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10620307": { "compartment": "compartment_70101", "id": "reaction_10620307", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620302" ], "products": [ "species_10620304", "species_29420" ], "modifiers": [ [ "species_10620302", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681" ] }, "reaction_10620381": { "compartment": "compartment_70101", "id": "reaction_10620381", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620376" ], "products": [ "species_10620378", "species_29420" ], "modifiers": [ [ "species_10620376", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10641401": { "compartment": "compartment_7660", "id": "reaction_10641401", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641391" ], "products": [ "species_10641399", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00019884", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641432": { "compartment": "compartment_7660", "id": "reaction_10641432", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641415" ], "products": [ "species_10641430", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641275": { "compartment": "compartment_7660", "id": "reaction_10641275", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641264" ], "products": [ "species_10638173", "species_10641273" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00020915", "WBGene00006706", "O45012", "WBGene00020915", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638087": { "compartment": "compartment_7660", "id": "reaction_10638087", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638069", "species_10638074" ], "products": [ "species_10638084", "species_164121", "species_113541" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10642632": { "compartment": "compartment_7660", "id": "reaction_10642632", "reactome": "R-CEL-5228508", "name": "RANBP2 SUMOylates PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10641447": { "compartment": "compartment_7660", "id": "reaction_10641447", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641437" ], "products": [ "species_10641445", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006595", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638321": { "compartment": "compartment_7660", "id": "reaction_10638321", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10638318", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10641361": { "compartment": "compartment_7660", "id": "reaction_10641361", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10598194" ], "products": [ "species_10638173", "species_10641359" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003955", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640956": { "compartment": "compartment_7660", "id": "reaction_10640956", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638173" ], "products": [ "species_10640954", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640528": { "compartment": "compartment_7660", "id": "reaction_10640528", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628901" ], "products": [ "species_10640526", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00000366", "P34545", "WBGene00000366", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641199": { "compartment": "compartment_13231", "id": "reaction_10641199", "reactome": "R-CEL-4551649", "name": "RANBP2 SUMOylates RANBP2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641186", "species_10638181" ], "products": [ "species_10641196", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00003795", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q86G90", "WBGene00003795", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10638341": { "compartment": "compartment_13231", "id": "reaction_10638341", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638328", "species_10638181" ], "products": [ "species_10638338", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641300": { "compartment": "compartment_7660", "id": "reaction_10641300", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641290", "species_10638181" ], "products": [ "species_10641298", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640543": { "compartment": "compartment_7660", "id": "reaction_10640543", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640533", "species_10638181" ], "products": [ "species_10640541", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640987": { "compartment": "compartment_7660", "id": "reaction_10640987", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10640977" ], "products": [ "species_10638173", "species_10640985" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001994", "WBGene00006706", "Q8MQ70", "WBGene00001994", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638449": { "compartment": "compartment_7660", "id": "reaction_10638449", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10636923" ], "products": [ "species_10638413", "species_10638173" ], "modifiers": [ [ "species_10638446", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "P55853", "WBGene00004888", "WBGene00006706", "Q9XTV3", "WBGene00010409", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q18237", "WBGene00016151", "G5EG17", "WBGene00010056" ] }, "reaction_10641326": { "compartment": "compartment_70101", "id": "reaction_10641326", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641324" ], "products": [], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10640476": { "compartment": "compartment_70101", "id": "reaction_10640476", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640470" ], "products": [ "species_10640474" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438" ] }, "reaction_10641973": { "compartment": "compartment_20592", "id": "reaction_10641973", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641961" ], "products": [ "species_10641971" ], "modifiers": [ [ "species_10641907", "catalyst" ] ], "additional_components": [ "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10641915": { "compartment": "compartment_876", "id": "reaction_10641915", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612022", "species_10641880" ], "products": [ "species_10641884" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238" ] }, "reaction_10641963": { "compartment": "compartment_876", "id": "reaction_10641963", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639064", "species_10641959" ], "products": [ "species_10641961" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b" ] }, "reaction_10641878": { "compartment": "compartment_876", "id": "reaction_10641878", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641874", "species_10639064" ], "products": [ "species_10641876" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238", "WBGene00000858", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238" ] }, "reaction_10641891": { "compartment": "compartment_876", "id": "reaction_10641891", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641884" ], "products": [ "species_29370", "species_10641886" ], "modifiers": [ [ "species_10641888", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10641913": { "compartment": "compartment_876", "id": "reaction_10641913", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10641907", "species_10641886" ], "products": [ "species_10641911" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238" ] }, "reaction_10640492": { "compartment": "compartment_876", "id": "reaction_10640492", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640488", "species_10640486" ], "products": [ "species_10640490" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10641957": { "compartment": "compartment_20592", "id": "reaction_10641957", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641911" ], "products": [ "species_10618761", "species_10641955" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P90961", "WBGene00020246", "Q9N532", "WBGene00003238" ] }, "reaction_10641882": { "compartment": "compartment_876", "id": "reaction_10641882", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640846", "species_10639064" ], "products": [ "species_10641880" ], "modifiers": [], "additional_components": [ "WBGene00003238", "WBGene00000858", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238" ] }, "reaction_10660033": { "compartment": "compartment_876", "id": "reaction_10660033", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10657991", "species_10658032" ], "products": [ "species_10660031" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q9U2S4", "WBGene00000184", "Q23165", "WBGene00000166", "G5EDJ4", "WBGene00004928", "species_29438" ] }, "reaction_10643599": { "compartment": "compartment_876", "id": "reaction_10643599", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643587" ], "products": [ "species_10643597" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10631246": { "compartment": "compartment_70101", "id": "reaction_10631246", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611990", "species_10611940" ], "products": [ "species_10611992" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10612002": { "compartment": "compartment_876", "id": "reaction_10612002", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611992" ], "products": [ "species_29370", "species_10611999" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10603107": { "compartment": "compartment_7660", "id": "reaction_10603107", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602942" ], "products": [ "species_113582", "species_113550", "species_10602934" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10604747": { "compartment": "compartment_7660", "id": "reaction_10604747", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10603821" ], "products": [ "species_113541", "species_10603858" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664877": { "compartment": "compartment_7660", "id": "reaction_10664877", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602904" ], "products": [ "species_164121", "species_113541", "species_10602904" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602967" ], "products": [ "species_10603821", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602969": { "compartment": "compartment_7660", "id": "reaction_10602969", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602952" ], "products": [ "species_10602967", "species_10602053", "species_10602065", "species_113541", "species_10601970" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602954": { "compartment": "compartment_7660", "id": "reaction_10602954", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602904" ], "products": [ "species_10601975", "species_10602952", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "WBGene00006648", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664879": { "compartment": "compartment_7660", "id": "reaction_10664879", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10602907": { "compartment": "compartment_7660", "id": "reaction_10602907", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_113541", "species_10602904" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10598407": { "compartment": "compartment_70101", "id": "reaction_10598407", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10598404", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10639536": { "compartment": "compartment_70101", "id": "reaction_10639536", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639531" ], "products": [ "species_110096", "species_10639533" ], "modifiers": [ [ "species_10639531", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640276": { "compartment": "compartment_70101", "id": "reaction_10640276", "reactome": "R-CEL-3780994", "name": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10640268" ], "products": [ "species_109402", "species_10640273" ], "modifiers": [ [ "species_10640268", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640292": { "compartment": "compartment_70101", "id": "reaction_10640292", "reactome": "R-CEL-3780997", "name": "PPP1R3C binds to glycogen:GYG2:GYS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639518", "species_10640266" ], "products": [ "species_10640268" ], "modifiers": [], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10665117": { "compartment": "compartment_70101", "id": "reaction_10665117", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10665114", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_109496" ] }, "reaction_10639526": { "compartment": "compartment_70101", "id": "reaction_10639526", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639508" ], "products": [ "species_10639518" ], "modifiers": [ [ "species_10639523", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10639511": { "compartment": "compartment_70101", "id": "reaction_10639511", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639506" ], "products": [ "species_110096", "species_10639508" ], "modifiers": [ [ "species_10639506", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640297": { "compartment": "compartment_70101", "id": "reaction_10640297", "reactome": "R-CEL-3781011", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10640294" ], "products": [ "species_10640282", "species_29372" ], "modifiers": [ [ "species_10640294", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10639516": { "compartment": "compartment_70101", "id": "reaction_10639516", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639513" ], "products": [ "species_110096", "species_10639506" ], "modifiers": [ [ "species_10639513", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10648882": { "compartment": "compartment_70101", "id": "reaction_10648882", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_193132" ], "products": [ "species_70106", "species_29364", "species_193066" ], "modifiers": [ [ "species_10648879", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10666026": { "compartment": "compartment_70101", "id": "reaction_10666026", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10666023", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q23431", "WBGene00014241", "Q19605", "WBGene00009635" ] }, "reaction_10610423": { "compartment": "compartment_70101", "id": "reaction_10610423", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193057" ], "products": [ "species_29366", "species_29460", "species_29356", "species_193132" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10661727": { "compartment": "compartment_70101", "id": "reaction_10661727", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10661724", "catalyst" ] ], "additional_components": [ "Q9N415", "WBGene00006513", "C7FZU5", "WBGene00077771" ] }, "reaction_10610421": { "compartment": "compartment_70101", "id": "reaction_10610421", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10610416", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10622873": { "compartment": "compartment_70101", "id": "reaction_10622873", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10622870", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q19605", "WBGene00009635" ] }, "reaction_10630301": { "compartment": "compartment_984", "id": "reaction_10630301", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630297", "species_1449707" ], "products": [ "species_10630299" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:27584", "CHEBI:17026", "CHEBI:16973", "CHEBI:17650", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "CHEBI:27584", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "CHEBI:17026", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "CHEBI:16973", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:17650" ] }, "reaction_10649574": { "compartment": "compartment_5460", "id": "reaction_10649574", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696835", "species_113563" ], "products": [ "species_113600", "species_5696848", "species_113529" ], "modifiers": [ [ "species_10649571", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610735": { "compartment": "compartment_70101", "id": "reaction_10610735", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196095" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10666029": { "compartment": "compartment_70101", "id": "reaction_10666029", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10659973": { "compartment": "compartment_70101", "id": "reaction_10659973", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10659970" ], "products": [ "species_29370", "species_10659935" ], "modifiers": [ [ "species_10659970", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10666213": { "compartment": "compartment_984", "id": "reaction_10666213", "reactome": "R-CEL-9734070", "name": "Anti-MET recombinant therapeutic antibodies bind MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618556", "species_9734118" ], "products": [ "species_10666211" ], "modifiers": [], "additional_components": [ "WBGene00008711", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "Q9XVQ7", "WBGene00008711", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619" ] }, "reaction_10659977": { "compartment": "compartment_70101", "id": "reaction_10659977", "reactome": "R-CEL-8875482", "name": "CBL recruits CIN85:endophilin to ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10659944" ], "products": [ "species_10659975" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791" ] }, "reaction_10659981": { "compartment": "compartment_70101", "id": "reaction_10659981", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608658", "species_10659975" ], "products": [ "species_10659979" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10659947": { "compartment": "compartment_70101", "id": "reaction_10659947", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10659935" ], "products": [ "species_10659944" ], "modifiers": [ [ "species_10659935", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10604651": { "compartment": "compartment_7660", "id": "reaction_10604651", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604647", "species_10604634" ], "products": [ "species_10604649" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00014066", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604660": { "compartment": "compartment_7660", "id": "reaction_10604660", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_10604649" ], "products": [ "species_10604657" ], "modifiers": [ [ "species_10604649", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10610473": { "compartment": "compartment_70101", "id": "reaction_10610473", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_29366", "species_193707" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610467": { "compartment": "compartment_17951", "id": "reaction_10610467", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610455": { "compartment": "compartment_17951", "id": "reaction_10610455", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10606370": { "compartment": "compartment_70101", "id": "reaction_10606370", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194069", "species_194073" ], "products": [ "species_76194", "species_193416" ], "modifiers": [ [ "species_10606367", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "species_192356", "species_193472", "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10659836": { "compartment": "compartment_70101", "id": "reaction_10659836", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_5357505", "species_10659832" ], "products": [ "species_10659834" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_176655", "species_5357505", "Q21130", "WBGene00010505" ] }, "reaction_10610485": { "compartment": "compartment_70101", "id": "reaction_10610485", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9617026", "species_29364" ], "products": [ "species_29366", "species_193829" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610446": { "compartment": "compartment_70101", "id": "reaction_10610446", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610547": { "compartment": "compartment_876", "id": "reaction_10610547", "reactome": "R-CEL-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10610544", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "WBGene00003407" ] }, "reaction_10610453": { "compartment": "compartment_17951", "id": "reaction_10610453", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193514", "species_193453" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:16525", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610260": { "compartment": "compartment_70101", "id": "reaction_10610260", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610277": { "compartment": "compartment_17951", "id": "reaction_10610277", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193514", "species_193404" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610465": { "compartment": "compartment_70101", "id": "reaction_10610465", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10666209": { "compartment": "compartment_70101", "id": "reaction_10666209", "reactome": "R-CEL-9733973", "name": "Bile salts bind FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643137", "species_194156" ], "products": [ "species_10666205" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274" ] }, "reaction_10610287": { "compartment": "compartment_17951", "id": "reaction_10610287", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10666207": { "compartment": "compartment_70101", "id": "reaction_10666207", "reactome": "R-CEL-9733969", "name": "Bile salts dissociate from FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666205" ], "products": [ "species_10643137", "species_194156" ], "modifiers": [], "additional_components": [ "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274" ] }, "reaction_10610477": { "compartment": "compartment_17951", "id": "reaction_10610477", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610489": { "compartment": "compartment_70101", "id": "reaction_10610489", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610433": { "compartment": "compartment_17951", "id": "reaction_10610433", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_141343" ], "products": [ "species_193514", "species_193451" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10610483": { "compartment": "compartment_70101", "id": "reaction_10610483", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193829" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610463": { "compartment": "compartment_70101", "id": "reaction_10610463", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610324": { "compartment": "compartment_17951", "id": "reaction_10610324", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10659235": { "compartment": "compartment_70101", "id": "reaction_10659235", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_1806234", "species_8868393" ], "modifiers": [ [ "species_10659232", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10606345": { "compartment": "compartment_70101", "id": "reaction_10606345", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_194096" ], "products": [ "species_111294", "species_76577", "species_29356", "species_194073" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "CHEBI:16755", "species_193451", "species_192356", "species_193472", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10659112": { "compartment": "compartment_70101", "id": "reaction_10659112", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10659109", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10610262": { "compartment": "compartment_70101", "id": "reaction_10610262", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610425": { "compartment": "compartment_17951", "id": "reaction_10610425", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10610475": { "compartment": "compartment_70101", "id": "reaction_10610475", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610457": { "compartment": "compartment_17951", "id": "reaction_10610457", "reactome": "R-CEL-193533", "name": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_193403" ], "products": [ "species_192314", "species_193472" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610528": { "compartment": "compartment_876", "id": "reaction_10610528", "reactome": "R-CEL-194121", "name": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610525", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610469": { "compartment": "compartment_70101", "id": "reaction_10610469", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610258": { "compartment": "compartment_17951", "id": "reaction_10610258", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610459": { "compartment": "compartment_17951", "id": "reaction_10610459", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610451": { "compartment": "compartment_17951", "id": "reaction_10610451", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610479": { "compartment": "compartment_70101", "id": "reaction_10610479", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610448": { "compartment": "compartment_17951", "id": "reaction_10610448", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610233": { "compartment": "compartment_70101", "id": "reaction_10610233", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192136" ], "products": [ "species_29366", "species_191980" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610471": { "compartment": "compartment_70101", "id": "reaction_10610471", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193724" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610332": { "compartment": "compartment_17951", "id": "reaction_10610332", "reactome": "R-CEL-192341", "name": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_192339" ], "products": [ "species_192356", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610487": { "compartment": "compartment_70101", "id": "reaction_10610487", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610481": { "compartment": "compartment_70101", "id": "reaction_10610481", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193707" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610552": { "compartment": "compartment_876", "id": "reaction_10610552", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610549", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610264": { "compartment": "compartment_70101", "id": "reaction_10610264", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191980" ], "products": [ "species_29366", "species_192030" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610442": { "compartment": "compartment_70101", "id": "reaction_10610442", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10643250": { "compartment": "compartment_7660", "id": "reaction_10643250", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10616320" ], "products": [ "species_10643248" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "species_176655", "CHEBI:16755", "species_5357505", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908" ] }, "reaction_10610198": { "compartment": "compartment_70101", "id": "reaction_10610198", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10610195", "catalyst" ] ], "additional_components": [ "species_113531", "Q20027", "WBGene00018036" ] }, "reaction_10610250": { "compartment": "compartment_70101", "id": "reaction_10610250", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610444": { "compartment": "compartment_70101", "id": "reaction_10610444", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10614222": { "compartment": "compartment_13231", "id": "reaction_10614222", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605337" ], "products": [ "species_10614220" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10614879": { "compartment": "compartment_7660", "id": "reaction_10614879", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614875", "species_29428" ], "products": [ "species_10614877" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10665078": { "compartment": "compartment_876", "id": "reaction_10665078", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_10665063" ], "products": [ "species_10665076" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838" ] }, "reaction_10649463": { "compartment": "compartment_70101", "id": "reaction_10649463", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10649460", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10665073": { "compartment": "compartment_7660", "id": "reaction_10665073", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665069" ], "products": [ "species_10665071" ], "modifiers": [ [ "species_10607578", "catalyst" ], [ "species_10611037", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "WBGene00002078", "P39745", "WBGene00003401" ] }, "reaction_10661072": { "compartment": "compartment_7660", "id": "reaction_10661072", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10661060" ], "products": [ "species_10661062" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10664151": { "compartment": "compartment_7660", "id": "reaction_10664151", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664147", "species_10664133" ], "products": [ "species_10664149" ], "modifiers": [], "additional_components": [ "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q21187", "WBGene00001441", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9TYU5", "WBGene00007029", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "P34545", "WBGene00000366", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q9N3S7", "WBGene00021636", "Q21187", "WBGene00001441", "Q9TYU5", "WBGene00007029", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066" ] }, "reaction_10611449": { "compartment": "compartment_70101", "id": "reaction_10611449", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_76194", "species_201034" ], "modifiers": [ [ "species_10611446", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9U2F2", "WBGene00012907", "Q23066", "WBGene00020911", "O16992", "WBGene00021002", "G5EG54", "WBGene00008629", "Q9N3N3", "WBGene00021703", "O44619", "WBGene00019644" ] }, "reaction_10643512": { "compartment": "compartment_70101", "id": "reaction_10643512", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643509", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "O01758", "WBGene00000966", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "O16881", "WBGene00000979", "Q19843", "WBGene00000992", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10663480": { "compartment": "compartment_7660", "id": "reaction_10663480", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649873", "species_10663476", "species_10663464" ], "products": [ "species_10663462", "species_10628319", "species_10663478" ], "modifiers": [], "additional_components": [ "G5EF71", "WBGene00003180", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "Q17381", "WBGene00004013", "Q21187", "WBGene00001441", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "P45972", "WBGene00011639", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00011639", "WBGene00001834", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "B7WN96", "WBGene00001251", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XUW7", "WBGene00001311", "P04255", "WBGene00001885", "P28515", "WBGene00001249", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21187", "WBGene00001441", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10644649": { "compartment": "compartment_70101", "id": "reaction_10644649", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10665002": { "compartment": "compartment_7660", "id": "reaction_10665002", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10644961": { "compartment": "compartment_70101", "id": "reaction_10644961", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643550" ], "products": [ "species_10643552" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665085": { "compartment": "compartment_876", "id": "reaction_10665085", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665076" ], "products": [ "species_10665080" ], "modifiers": [], "additional_components": [ "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10665066": { "compartment": "compartment_876", "id": "reaction_10665066", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665058", "species_113592" ], "products": [ "species_29370", "species_10665063" ], "modifiers": [ [ "species_10665058", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838" ] }, "reaction_10666083": { "compartment": "compartment_7660", "id": "reaction_10666083", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661066", "species_1254400" ], "products": [ "species_10661068" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10612137": { "compartment": "compartment_70101", "id": "reaction_10612137", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10612134", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10645853": { "compartment": "compartment_70101", "id": "reaction_10645853", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643186" ], "products": [ "species_10645851" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643570": { "compartment": "compartment_70101", "id": "reaction_10643570", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_30927" ], "products": [ "species_70106", "species_73473", "species_32737" ], "modifiers": [ [ "species_10643567", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10643188": { "compartment": "compartment_70101", "id": "reaction_10643188", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643184" ], "products": [ "species_10643186" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643631": { "compartment": "compartment_70101", "id": "reaction_10643631", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10643628", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "G5EET7", "WBGene00011940", "G5EGA6", "WBGene00010063", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q1XFZ3", "WBGene00000980" ] }, "reaction_10663581": { "compartment": "compartment_7660", "id": "reaction_10663581", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663576", "species_29358" ], "products": [ "species_113582", "species_10663578" ], "modifiers": [ [ "species_10663576", "catalyst" ] ], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10643557": { "compartment": "compartment_70101", "id": "reaction_10643557", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643554", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10644959": { "compartment": "compartment_70101", "id": "reaction_10644959", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_5334816" ], "products": [ "species_10644957" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665037": { "compartment": "compartment_876", "id": "reaction_10665037", "reactome": "R-CEL-9625482", "name": "PTK2 binds activated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10608528" ], "products": [ "species_10665035" ], "modifiers": [], "additional_components": [ "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10665042": { "compartment": "compartment_876", "id": "reaction_10665042", "reactome": "R-CEL-9625487", "name": "PTK2 autophosphorylates downstream of EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10665035" ], "products": [ "species_29370", "species_10665039" ], "modifiers": [ [ "species_10665035", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643533": { "compartment": "compartment_70101", "id": "reaction_10643533", "reactome": "R-CEL-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10643530", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10645837": { "compartment": "compartment_70101", "id": "reaction_10645837", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644957" ], "products": [ "species_10645835" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665044": { "compartment": "compartment_876", "id": "reaction_10665044", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10645083": { "compartment": "compartment_70616", "id": "reaction_10645083", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10645080", "catalyst" ] ], "additional_components": [ "WBGene00000987" ] }, "reaction_10665082": { "compartment": "compartment_7660", "id": "reaction_10665082", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607884" ], "products": [ "species_10611037" ], "modifiers": [ [ "species_10665080", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10633165": { "compartment": "compartment_20699", "id": "reaction_10633165", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633162", "catalyst" ] ], "additional_components": [ "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633271": { "compartment": "compartment_20699", "id": "reaction_10633271", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633120": { "compartment": "compartment_20699", "id": "reaction_10633120", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10633117", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10633297": { "compartment": "compartment_20699", "id": "reaction_10633297", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633160", "species_10633295" ], "products": [ "species_10633162" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183", "WBGene00018076", "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633321": { "compartment": "compartment_20699", "id": "reaction_10633321", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633318", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10633208": { "compartment": "compartment_20699", "id": "reaction_10633208", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633279": { "compartment": "compartment_20699", "id": "reaction_10633279", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633176": { "compartment": "compartment_20699", "id": "reaction_10633176", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10633173", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10666348": { "compartment": "compartment_7660", "id": "reaction_10666348", "reactome": "R-CEL-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597804", "species_10597787" ], "products": [ "species_10597806" ], "modifiers": [], "additional_components": [ "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10597692": { "compartment": "compartment_7660", "id": "reaction_10597692", "reactome": "R-CEL-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597686", "species_10597678" ], "products": [ "species_10597690" ], "modifiers": [], "additional_components": [ "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XX17", "WBGene00012650", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882" ] }, "reaction_10666265": { "compartment": "compartment_7660", "id": "reaction_10666265", "reactome": "R-CEL-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597818", "species_10597806" ], "products": [ "species_10597820" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10666223": { "compartment": "compartment_70101", "id": "reaction_10666223", "reactome": "R-CEL-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666221" ], "products": [ "species_10597674" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10666346": { "compartment": "compartment_7660", "id": "reaction_10666346", "reactome": "R-CEL-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597797", "species_10597792", "species_10597802" ], "products": [ "species_10597804" ], "modifiers": [], "additional_components": [ "WBGene00003158", "WBGene00003156", "WBGene00003159", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158" ] }, "reaction_10666344": { "compartment": "compartment_7660", "id": "reaction_10666344", "reactome": "R-CEL-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597811", "species_10597816" ], "products": [ "species_10597818" ], "modifiers": [], "additional_components": [ "WBGene00003155", "WBGene00003157", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155" ] }, "reaction_10666263": { "compartment": "compartment_7660", "id": "reaction_10666263", "reactome": "R-CEL-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666259", "species_10597674" ], "products": [ "species_10666261" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00012650", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q9XX17", "WBGene00012650", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10612074": { "compartment": "compartment_70101", "id": "reaction_10612074", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612026" ], "products": [ "species_29370", "species_10612049" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10640242": { "compartment": "compartment_70101", "id": "reaction_10640242", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612049" ], "products": [ "species_29370", "species_10611988" ], "modifiers": [ [ "species_10640239", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00002203" ] }, "reaction_10640245": { "compartment": "compartment_70101", "id": "reaction_10640245", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10640232", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10640234": { "compartment": "compartment_70101", "id": "reaction_10640234", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633032", "species_10611988" ], "products": [ "species_10640232" ], "modifiers": [], "additional_components": [ "WBGene00004087", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10605873": { "compartment": "compartment_7660", "id": "reaction_10605873", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605860" ], "products": [ "species_113582", "species_10605864" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10637119": { "compartment": "compartment_70101", "id": "reaction_10637119", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637115" ], "products": [ "species_29370", "species_10637105" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665030": { "compartment": "compartment_70101", "id": "reaction_10665030", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10665018" ], "products": [ "species_10665028" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10664962": { "compartment": "compartment_70101", "id": "reaction_10664962", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602699", "species_10664958" ], "products": [ "species_10664960" ], "modifiers": [], "additional_components": [ "P91457", "WBGene00003793", "Q17602", "WBGene00003800", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10636865": { "compartment": "compartment_1598585", "id": "reaction_10636865", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636850" ], "products": [ "species_29370", "species_10636862" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10665723": { "compartment": "compartment_13231", "id": "reaction_10665723", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665704", "species_10665708" ], "products": [ "species_10665710" ], "modifiers": [], "additional_components": [ "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636955": { "compartment": "compartment_7660", "id": "reaction_10636955", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636925", "species_10636923", "species_10636929" ], "products": [ "species_10636931" ], "modifiers": [], "additional_components": [ "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "WBGene00019953", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665026": { "compartment": "compartment_1598585", "id": "reaction_10665026", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10649915" ], "products": [ "species_10665018", "species_29420" ], "modifiers": [ [ "species_10665023", "catalyst" ] ], "additional_components": [ "species_29420", "O17915", "WBGene00004302", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10665033": { "compartment": "compartment_70101", "id": "reaction_10665033", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665028", "species_29356" ], "products": [ "species_10649915", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10638338", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "species_29420", "O17915", "WBGene00004302", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10638249": { "compartment": "compartment_70101", "id": "reaction_10638249", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638243", "species_10638238" ], "products": [ "species_10638247" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "Q19848", "WBGene00017895", "H2KZB2", "WBGene00021945" ] }, "reaction_10665721": { "compartment": "compartment_70101", "id": "reaction_10665721", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665712", "species_10665717" ], "products": [ "species_10665719" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00021334", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q9BL83", "WBGene00021334", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636984": { "compartment": "compartment_1598585", "id": "reaction_10636984", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10636976", "species_10636931" ], "products": [ "species_10636982" ], "modifiers": [], "additional_components": [ "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q95XZ5", "WBGene00004166", "Q19325", "WBGene00004737", "O17581", "WBGene00003136", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665725": { "compartment": "compartment_70101", "id": "reaction_10665725", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665710", "species_10665699" ], "products": [ "species_10665712" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00016045", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10665728": { "compartment": "compartment_70101", "id": "reaction_10665728", "reactome": "R-CEL-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_10616987" ], "modifiers": [ [ "species_10665712", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636891": { "compartment": "compartment_70101", "id": "reaction_10636891", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636880" ], "products": [ "species_10636888" ], "modifiers": [ [ "species_10636880", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10636964": { "compartment": "compartment_1598585", "id": "reaction_10636964", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636961" ], "products": [ "species_29370", "species_10636850" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10637117": { "compartment": "compartment_70101", "id": "reaction_10637117", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637105", "species_29356" ], "products": [ "species_10637115", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087" ] }, "reaction_10605887": { "compartment": "compartment_7660", "id": "reaction_10605887", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605878", "species_113592" ], "products": [ "species_29370", "species_10605882" ], "modifiers": [ [ "species_10605884", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10665692": { "compartment": "compartment_70101", "id": "reaction_10665692", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625894", "species_10638238" ], "products": [ "species_10665690" ], "modifiers": [], "additional_components": [ "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00021945", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "H2KZB2", "WBGene00021945" ] }, "reaction_10662392": { "compartment": "compartment_17957", "id": "reaction_10662392", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662092", "species_8931885" ], "products": [ "species_10662385", "species_8931884" ], "modifiers": [ [ "species_10662092", "catalyst" ], [ "species_10662390", "catalyst" ] ], "additional_components": [ "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q9XTW2", "WBGene00010356" ] }, "reaction_10616363": { "compartment": "compartment_17938", "id": "reaction_10616363", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616360", "species_113592" ], "products": [ "species_29370", "species_10606983" ], "modifiers": [ [ "species_10612120", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662470": { "compartment": "compartment_70101", "id": "reaction_10662470", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10606953", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607018": { "compartment": "compartment_17938", "id": "reaction_10607018", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606964", "species_113592" ], "products": [ "species_29370", "species_10606968" ], "modifiers": [ [ "species_10606957", "catalyst" ], [ "species_10606997", "catalyst" ], [ "species_10606979", "inhibitor" ], [ "species_10607016", "inhibitor" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10617104": { "compartment": "compartment_70101", "id": "reaction_10617104", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611523" ], "products": [ "species_10611508", "species_29372" ], "modifiers": [ [ "species_10617101", "catalyst" ] ], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460" ] }, "reaction_10607031": { "compartment": "compartment_70101", "id": "reaction_10607031", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601072" ], "products": [ "species_29370", "species_10607028" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "WBGene00012929" ] }, "reaction_10606878": { "compartment": "compartment_17938", "id": "reaction_10606878", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606874", "species_29438" ], "products": [ "species_10606876", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10665764": { "compartment": "compartment_70101", "id": "reaction_10665764", "reactome": "R-CEL-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10607014" ], "products": [ "species_10607016" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10646908": { "compartment": "compartment_17938", "id": "reaction_10646908", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606997" ], "products": [ "species_29370", "species_10646905" ], "modifiers": [ [ "species_10606997", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607048": { "compartment": "compartment_70101", "id": "reaction_10607048", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601231" ], "products": [ "species_29370", "species_10607046" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "WBGene00012929" ] }, "reaction_10646165": { "compartment": "compartment_70101", "id": "reaction_10646165", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606947", "species_10606934" ], "products": [ "species_10606949" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414", "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414" ] }, "reaction_10646899": { "compartment": "compartment_17938", "id": "reaction_10646899", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606983", "species_10606995" ], "products": [ "species_10606997" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10606959": { "compartment": "compartment_70101", "id": "reaction_10606959", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10606955" ], "products": [ "species_10606957" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607041": { "compartment": "compartment_70101", "id": "reaction_10607041", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607036" ], "products": [ "species_29370", "species_10607039" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "WBGene00012929" ] }, "reaction_10646167": { "compartment": "compartment_17938", "id": "reaction_10646167", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606953", "species_10606895" ], "products": [ "species_10606955" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10622209": { "compartment": "compartment_876", "id": "reaction_10622209", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606957" ], "products": [ "species_29370", "species_10606979" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10617095": { "compartment": "compartment_70101", "id": "reaction_10617095", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_10611523" ], "products": [ "species_10617093" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605906", "species_10605890" ], "products": [ "species_10605908" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00004428", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10605914": { "compartment": "compartment_70101", "id": "reaction_10605914", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601533" ], "products": [ "species_10605912", "species_10601331" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00004428" ] }, "reaction_10665593": { "compartment": "compartment_876", "id": "reaction_10665593", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10665590", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EGA7", "WBGene00004311", "Q22875", "WBGene00004929", "species_29438", "Q27497", "WBGene00001747", "P48727", "WBGene00001748" ] }, "reaction_10665461": { "compartment": "compartment_12045", "id": "reaction_10665461", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346" ], "products": [ "species_10607835" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10635276": { "compartment": "compartment_70101", "id": "reaction_10635276", "reactome": "R-CEL-2028735", "name": "AMOT proteins bind WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635239" ], "products": [ "species_10635274" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10647126": { "compartment": "compartment_876", "id": "reaction_10647126", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10647122" ], "products": [ "species_10647124" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017144", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10640339": { "compartment": "compartment_383505", "id": "reaction_10640339", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640317" ], "products": [ "species_10640337" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10658530": { "compartment": "compartment_876", "id": "reaction_10658530", "reactome": "R-CEL-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658515", "species_29356" ], "products": [ "species_10658527", "species_29372" ], "modifiers": [ [ "species_10658515", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10640341": { "compartment": "compartment_876", "id": "reaction_10640341", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10640317" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10609406": { "compartment": "compartment_70101", "id": "reaction_10609406", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10609384", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617376": { "compartment": "compartment_984", "id": "reaction_10617376", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617364" ], "products": [ "species_10617374" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10665529": { "compartment": "compartment_17906", "id": "reaction_10665529", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665523", "species_10625038" ], "products": [ "species_10665527" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P22981", "WBGene00002335", "P41958", "WBGene00000423" ] }, "reaction_10665450": { "compartment": "compartment_12045", "id": "reaction_10665450", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665357" ], "products": [ "species_10665341" ], "modifiers": [ [ "species_10665447", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10646527": { "compartment": "compartment_7660", "id": "reaction_10646527", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646523", "species_10639320" ], "products": [ "species_10646525" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10665525": { "compartment": "compartment_17906", "id": "reaction_10665525", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665507" ], "products": [ "species_10665523" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10647016": { "compartment": "compartment_876", "id": "reaction_10647016", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647013", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "W6RS10", "WBGene00019902", "Q21408", "WBGene00004951", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "C6KRM7", "WBGene00004372", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "E0AHA7", "WBGene00006803", "species_114519", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XWK4", "WBGene00013202", "G5EDB9", "WBGene00004254", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "Q19770", "WBGene00009100", "O18008", "WBGene00021745", "G5EFW3", "WBGene00004855" ] }, "reaction_10611938": { "compartment": "compartment_70101", "id": "reaction_10611938", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610707" ], "products": [ "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10617354": { "compartment": "compartment_20699", "id": "reaction_10617354", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617336" ], "products": [ "species_10617352" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10635617": { "compartment": "compartment_70101", "id": "reaction_10635617", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635613" ], "products": [ "species_10635615" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10642546": { "compartment": "compartment_70101", "id": "reaction_10642546", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642538", "species_113592" ], "products": [ "species_29370", "species_10642543", "species_10620766" ], "modifiers": [ [ "species_10609574", "catalyst" ] ], "additional_components": [ "species_113592", "A0A1I6CMC9", "WBGene00021943", "P10984", "WBGene00000064", "WBGene00021943", "species_113592", "P10984", "WBGene00000064", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10609380": { "compartment": "compartment_876", "id": "reaction_10609380", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609278", "species_10609364" ], "products": [ "species_10609374" ], "modifiers": [ [ "species_10609376", "inhibitor" ], [ "species_10609378", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=9172", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665504": { "compartment": "compartment_876", "id": "reaction_10665504", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647018", "species_9657579" ], "products": [ "species_10647108" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10611822": { "compartment": "compartment_876", "id": "reaction_10611822", "reactome": "R-CEL-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611819" ], "products": [ "species_29370", "species_10611801" ], "modifiers": [ [ "species_10611819", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856" ] }, "reaction_10665991": { "compartment": "compartment_70101", "id": "reaction_10665991", "reactome": "R-CEL-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665979" ], "products": [ "species_10665989" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10643019": { "compartment": "compartment_171062", "id": "reaction_10643019", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602372", "species_10602367" ], "products": [ "species_10602374" ], "modifiers": [], "additional_components": [ "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10639026": { "compartment": "compartment_171062", "id": "reaction_10639026", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638950", "species_10638940", "species_10638945" ], "products": [ "species_10638952" ], "modifiers": [], "additional_components": [ "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "WBGene00003246", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10665465": { "compartment": "compartment_876", "id": "reaction_10665465", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10665981": { "compartment": "compartment_70101", "id": "reaction_10665981", "reactome": "R-CEL-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665977" ], "products": [ "species_10665979" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661675": { "compartment": "compartment_876", "id": "reaction_10661675", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_10642505" ], "products": [ "species_10642524" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10609414": { "compartment": "compartment_70101", "id": "reaction_10609414", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602407" ], "products": [ "species_10609412" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634222": { "compartment": "compartment_876", "id": "reaction_10634222", "reactome": "R-CEL-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10629224" ], "modifiers": [ [ "species_10634211", "catalyst" ], [ "species_10634220", "inhibitor" ], [ "species_10634216", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5082" ] }, "reaction_10664063": { "compartment": "compartment_70101", "id": "reaction_10664063", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10657704": { "compartment": "compartment_70101", "id": "reaction_10657704", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657699", "species_113592" ], "products": [ "species_10657701", "species_29370" ], "modifiers": [ [ "species_10657699", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10639068": { "compartment": "compartment_984", "id": "reaction_10639068", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10639066", "species_10639032" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00003246" ] }, "reaction_10631286": { "compartment": "compartment_876", "id": "reaction_10631286", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631284" ], "products": [ "species_10609280", "species_10612190" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038" ] }, "reaction_10640145": { "compartment": "compartment_70101", "id": "reaction_10640145", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640137" ], "products": [ "species_10640143" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979" ] }, "reaction_10639544": { "compartment": "compartment_7660", "id": "reaction_10639544", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10639320" ], "products": [ "species_10639542" ], "modifiers": [], "additional_components": [ "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "P34545", "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10643280": { "compartment": "compartment_876", "id": "reaction_10643280", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643276" ], "products": [ "species_10643278" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10665545": { "compartment": "compartment_70101", "id": "reaction_10665545", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665533", "species_10645503" ], "products": [ "species_10665537" ], "modifiers": [ [ "species_10665543", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q18268", "WBGene00003966", "pubchem.compound:73292904" ] }, "reaction_10641377": { "compartment": "compartment_70101", "id": "reaction_10641377", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612014", "species_10641373" ], "products": [ "species_10641375" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10635641": { "compartment": "compartment_70101", "id": "reaction_10635641", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10629362" ], "products": [ "species_10635623" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665516": { "compartment": "compartment_70101", "id": "reaction_10665516", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607835" ], "products": [ "species_10665507", "species_29370" ], "modifiers": [ [ "species_10665513", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "species_30991", "H2KYN2", "WBGene00015650" ] }, "reaction_10664691": { "compartment": "compartment_70101", "id": "reaction_10664691", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664678" ], "products": [ "species_29370", "species_10664684" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10648862": { "compartment": "compartment_7660", "id": "reaction_10648862", "reactome": "R-CEL-5692779", "name": "p-S182 MAPKAPK5 phosphorylates FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10648859" ], "modifiers": [ [ "species_10638831", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10648164": { "compartment": "compartment_70101", "id": "reaction_10648164", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648138" ], "products": [ "species_10648129" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10630128": { "compartment": "compartment_876", "id": "reaction_10630128", "reactome": "R-CEL-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10608459" ], "products": [ "species_10630119" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10639653": { "compartment": "compartment_7660", "id": "reaction_10639653", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639649", "species_10639647" ], "products": [ "species_10639318", "species_10639651" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424", "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q20595", "WBGene00006424" ] }, "reaction_10617040": { "compartment": "compartment_70101", "id": "reaction_10617040", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609408", "species_113592" ], "products": [ "species_29370", "species_10617037" ], "modifiers": [ [ "species_10609408", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635629": { "compartment": "compartment_70101", "id": "reaction_10635629", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635623" ], "products": [ "species_10635627" ], "modifiers": [], "additional_components": [ "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10639540": { "compartment": "compartment_7660", "id": "reaction_10639540", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605206", "species_10639320", "species_10605196" ], "products": [ "species_10639538" ], "modifiers": [], "additional_components": [ "WBGene00007110", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00018064", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10665743": { "compartment": "compartment_876", "id": "reaction_10665743", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_9674075" ], "products": [ "species_10617614" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=10368", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10639070": { "compartment": "compartment_20699", "id": "reaction_10639070", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639028" ], "products": [ "species_10639050" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10665520": { "compartment": "compartment_876", "id": "reaction_10665520", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10607835" ], "products": [ "species_10641023" ], "modifiers": [ [ "species_10665507", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10617616": { "compartment": "compartment_70101", "id": "reaction_10617616", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_113592" ], "products": [ "species_29370", "species_10617611" ], "modifiers": [ [ "species_10617609", "catalyst" ], [ "species_10617614", "inhibitor" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10665745": { "compartment": "compartment_876", "id": "reaction_10665745", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609364", "species_9674079" ], "products": [ "species_10609376" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5659", "LigandDisplayForward?ligandId=9175", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5656", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=5890", "LigandDisplayForward?ligandId=7426", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745" ] }, "reaction_10635241": { "compartment": "compartment_70101", "id": "reaction_10635241", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_10635225", "species_29370" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10635635": { "compartment": "compartment_70101", "id": "reaction_10635635", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635631" ], "products": [ "species_10635633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10659092": { "compartment": "compartment_70101", "id": "reaction_10659092", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659088", "species_10622260" ], "products": [ "species_10659090" ], "modifiers": [], "additional_components": [ "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10630135": { "compartment": "compartment_876", "id": "reaction_10630135", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10630132", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10638958": { "compartment": "compartment_20699", "id": "reaction_10638958", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638952" ], "products": [ "species_10638956" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10657399": { "compartment": "compartment_70101", "id": "reaction_10657399", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10625343" ], "products": [ "species_10657396" ], "modifiers": [ [ "species_10625343", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00004829", "WBGene00004829", "WBGene00004829" ] }, "reaction_10631237": { "compartment": "compartment_70101", "id": "reaction_10631237", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10612130" ], "products": [ "species_10612134" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10643283": { "compartment": "compartment_876", "id": "reaction_10643283", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643278" ], "products": [ "species_29370", "species_10618313", "species_10642526" ], "modifiers": [ [ "species_10617742", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10665468": { "compartment": "compartment_876", "id": "reaction_10665468", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837" ], "products": [ "species_10608583" ], "modifiers": [ [ "species_10607837", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10658628": { "compartment": "compartment_984", "id": "reaction_10658628", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617342" ], "products": [ "species_10609394", "species_10609276", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10602377": { "compartment": "compartment_17940", "id": "reaction_10602377", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10617380": { "compartment": "compartment_70101", "id": "reaction_10617380", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10615471" ], "products": [ "species_10617378" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00006410", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q95PX0", "WBGene00006410", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10648160": { "compartment": "compartment_70101", "id": "reaction_10648160", "reactome": "R-CEL-5687121", "name": "p-S MAPKAPK5 phosphorylates HSPB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642534" ], "products": [ "species_29370", "species_10648149" ], "modifiers": [ [ "species_10648157", "catalyst" ] ], "additional_components": [ "WBGene00021943", "WBGene00021943", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10657390": { "compartment": "compartment_70101", "id": "reaction_10657390", "reactome": "R-CEL-8848611", "name": "Phosphorylated PXN recruits the CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636369", "species_10657386" ], "products": [ "species_10657388" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419", "WBGene00016197", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10617078": { "compartment": "compartment_70101", "id": "reaction_10617078", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617074" ], "products": [ "species_10617076" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9NAD6", "WBGene00013111", "Q10656", "WBGene00001184", "Q20977", "WBGene00010251", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10642518": { "compartment": "compartment_876", "id": "reaction_10642518", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617912" ], "products": [ "species_29370", "species_10642515" ], "modifiers": [ [ "species_10642501", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "species_112275", "P34722", "WBGene00006599", "species_74016" ] }, "reaction_10664080": { "compartment": "compartment_70101", "id": "reaction_10664080", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664076", "species_10664058" ], "products": [ "species_10664078" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10646973": { "compartment": "compartment_70101", "id": "reaction_10646973", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10647020": { "compartment": "compartment_876", "id": "reaction_10647020", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646912", "species_10646941" ], "products": [ "species_10647018" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10665548": { "compartment": "compartment_876", "id": "reaction_10665548", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665539" ], "products": [ "species_10642764", "species_10645503", "species_10604898", "species_10607835" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10609386": { "compartment": "compartment_70101", "id": "reaction_10609386", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602421" ], "products": [ "species_10609384" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635677": { "compartment": "compartment_70101", "id": "reaction_10635677", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635266", "species_10612022" ], "products": [ "species_10635675" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q19404", "WBGene00008748" ] }, "reaction_10634132": { "compartment": "compartment_70101", "id": "reaction_10634132", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634129" ], "modifiers": [ [ "species_10627446", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10639322": { "compartment": "compartment_7660", "id": "reaction_10639322", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639318", "species_10611936" ], "products": [ "species_10639320", "species_10628319", "species_10639314" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "WBGene00001979", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00001834", "O02482", "WBGene00006773" ] }, "reaction_10634230": { "compartment": "compartment_876", "id": "reaction_10634230", "reactome": "R-CEL-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10634206" ], "modifiers": [ [ "species_10615184", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10647265": { "compartment": "compartment_876", "id": "reaction_10647265", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647259" ], "products": [ "species_10647263", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ], [ "species_10647209", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "WBGene00003030" ] }, "reaction_10647219": { "compartment": "compartment_876", "id": "reaction_10647219", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647024" ], "products": [ "species_29370", "species_10647217" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10634202": { "compartment": "compartment_876", "id": "reaction_10634202", "reactome": "R-CEL-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10634198" ], "products": [ "species_10634200" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "P24348", "WBGene00002299", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "G5EFK8", "WBGene00008779", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10609417": { "compartment": "compartment_70101", "id": "reaction_10609417", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10609412", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10645710": { "compartment": "compartment_7660", "id": "reaction_10645710", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645706", "species_10611936" ], "products": [ "species_10645708" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "WBGene00001979", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10643579": { "compartment": "compartment_7660", "id": "reaction_10643579", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611936", "species_10643575" ], "products": [ "species_10643577" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00007053", "O61845", "WBGene00007053", "O44326", "WBGene00001979" ] }, "reaction_10646962": { "compartment": "compartment_70101", "id": "reaction_10646962", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635257", "species_10646952" ], "products": [ "species_10646960" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10617360": { "compartment": "compartment_984", "id": "reaction_10617360", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609272", "species_10617356" ], "products": [ "species_10617358" ], "modifiers": [], "additional_components": [ "WBGene00004249", "CHEBI:18137", "CHEBI:17421", "P17139", "WBGene00001263", "CHEBI:18137", "Q9N413", "WBGene00004249", "CHEBI:17421", "P17139", "WBGene00001263" ] }, "reaction_10657409": { "compartment": "compartment_70101", "id": "reaction_10657409", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657402", "species_10605408" ], "products": [ "species_10657404" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10635470": { "compartment": "compartment_70101", "id": "reaction_10635470", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263" ], "products": [ "species_10635468" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10639738": { "compartment": "compartment_7660", "id": "reaction_10639738", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10639703" ], "products": [ "species_77502", "species_10639715" ], "modifiers": [ [ "species_10639735", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "O44447", "WBGene00015330", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "Q10666", "WBGene00004077", "G5EFZ3", "WBGene00012458" ] }, "reaction_10639030": { "compartment": "compartment_20699", "id": "reaction_10639030", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638954", "species_10639016" ], "products": [ "species_10639028" ], "modifiers": [], "additional_components": [ "WBGene00003246", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10642512": { "compartment": "compartment_876", "id": "reaction_10642512", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642509" ], "products": [ "species_29370", "species_10642479" ], "modifiers": [ [ "species_10604441", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10635253": { "compartment": "compartment_70101", "id": "reaction_10635253", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635210" ], "products": [ "species_10635212" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10612216": { "compartment": "compartment_876", "id": "reaction_10612216", "reactome": "R-CEL-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611811", "species_10611783" ], "products": [ "species_10611813" ], "modifiers": [], "additional_components": [ "Q09488", "WBGene00004860", "P50488", "WBGene00000900", "P50488", "WBGene00000900", "Q09488", "WBGene00004860" ] }, "reaction_10635251": { "compartment": "compartment_70101", "id": "reaction_10635251", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_29370", "species_10635248" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10611755": { "compartment": "compartment_7660", "id": "reaction_10611755", "reactome": "R-CEL-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607878", "species_10611751" ], "products": [ "species_10611753" ], "modifiers": [], "additional_components": [ "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EDM7", "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10647134": { "compartment": "compartment_876", "id": "reaction_10647134", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10647124" ], "products": [ "species_10647131" ], "modifiers": [ [ "species_10647124", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10665384": { "compartment": "compartment_20699", "id": "reaction_10665384", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346", "species_200993" ], "products": [ "species_10665366", "species_76194" ], "modifiers": [ [ "species_10665381", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10647164": { "compartment": "compartment_20699", "id": "reaction_10647164", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647160", "species_10646952" ], "products": [ "species_10647162" ], "modifiers": [], "additional_components": [ "WBGene00013457", "WBGene00003030", "Q07292", "WBGene00003030", "Q9U1V1", "WBGene00013457" ] }, "reaction_10639023": { "compartment": "compartment_17963", "id": "reaction_10639023", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639000" ], "products": [ "species_10639016" ], "modifiers": [ [ "species_10639021", "catalyst" ] ], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00010670" ] }, "reaction_10635639": { "compartment": "compartment_70101", "id": "reaction_10635639", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10635263" ], "products": [ "species_10635637" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665440": { "compartment": "compartment_876", "id": "reaction_10665440", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607833", "species_29356" ], "products": [ "species_8848337", "species_10607835" ], "modifiers": [ [ "species_10665433", "catalyst" ], [ "species_10665435", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10639074": { "compartment": "compartment_20699", "id": "reaction_10639074", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638956" ], "products": [ "species_10638954", "species_10638950", "species_10638940" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "WBGene00003246", "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234" ] }, "reaction_10617748": { "compartment": "compartment_70101", "id": "reaction_10617748", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617721", "species_10617742" ], "products": [ "species_10617744", "species_10617746" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10609286": { "compartment": "compartment_876", "id": "reaction_10609286", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10609282" ], "products": [ "species_10609284" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10643316": { "compartment": "compartment_876", "id": "reaction_10643316", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643309" ], "products": [ "species_29370", "species_10643313" ], "modifiers": [ [ "species_10618313", "catalyst" ] ], "additional_components": [ "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10631289": { "compartment": "compartment_876", "id": "reaction_10631289", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609284" ], "products": [ "species_29370", "species_10631284" ], "modifiers": [ [ "species_10609284", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617362": { "compartment": "compartment_70101", "id": "reaction_10617362", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617312" ], "products": [ "species_10617314" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q95XA9", "WBGene00021238", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665502": { "compartment": "compartment_70101", "id": "reaction_10665502", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10634127" ], "products": [ "species_10634220" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686" ] }, "reaction_10648147": { "compartment": "compartment_70101", "id": "reaction_10648147", "reactome": "R-CEL-5687101", "name": "p-T182 MAPKAPK5 phosphorylates FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648136" ], "products": [ "species_29370", "species_10648138" ], "modifiers": [ [ "species_10648144", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647202": { "compartment": "compartment_70101", "id": "reaction_10647202", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647083" ], "products": [ "species_29370", "species_10647199" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10611733": { "compartment": "compartment_70101", "id": "reaction_10611733", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611729", "species_10607715" ], "products": [ "species_10611731" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666054": { "compartment": "compartment_263163", "id": "reaction_10666054", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_29356" ], "products": [ "species_10666051", "species_29372" ], "modifiers": [ [ "species_10666039", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29370", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10630126": { "compartment": "compartment_876", "id": "reaction_10630126", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10630123", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EDP9", "WBGene00000001", "G5EFK8", "WBGene00008779" ] }, "reaction_10646970": { "compartment": "compartment_70101", "id": "reaction_10646970", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646968" ], "products": [ "species_10646912", "species_10635257" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10648126": { "compartment": "compartment_7660", "id": "reaction_10648126", "reactome": "R-CEL-5687088", "name": "PKA phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638817" ], "products": [ "species_113582", "species_10648121" ], "modifiers": [ [ "species_10648123", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "WBGene00002189" ] }, "reaction_10665350": { "compartment": "compartment_12045", "id": "reaction_10665350", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665341", "species_71284" ], "products": [ "species_71285", "species_10665346" ], "modifiers": [ [ "species_10650360", "catalyst" ], [ "species_10665348", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216667", "P91402", "WBGene00019710", "species_216667", "pubchem.compound:6918831", "P91402", "WBGene00019710" ] }, "reaction_10665437": { "compartment": "compartment_876", "id": "reaction_10665437", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10665433" ], "products": [ "species_10665435" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10611834": { "compartment": "compartment_876", "id": "reaction_10611834", "reactome": "R-CEL-201510", "name": "PI3K synthesizes PIP3 downstream of ALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10611831", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10612132": { "compartment": "compartment_70101", "id": "reaction_10612132", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612122", "species_113592" ], "products": [ "species_29370", "species_10612130" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665372": { "compartment": "compartment_876", "id": "reaction_10665372", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665366" ], "products": [ "species_10607833" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10646948": { "compartment": "compartment_876", "id": "reaction_10646948", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10646939" ], "products": [ "species_10646941" ], "modifiers": [ [ "species_10646946", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00004014" ] }, "reaction_10635472": { "compartment": "compartment_70101", "id": "reaction_10635472", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362" ], "products": [ "species_10629366" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10665568": { "compartment": "compartment_876", "id": "reaction_10665568", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10602421" ], "products": [ "species_10665566" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P22981", "WBGene00002335", "species_29438", "G5EDP9", "WBGene00000001" ] }, "reaction_10643318": { "compartment": "compartment_876", "id": "reaction_10643318", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617742", "species_10642526" ], "products": [ "species_10643276" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10664074": { "compartment": "compartment_17906", "id": "reaction_10664074", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664068", "species_10664058" ], "products": [ "species_10664072" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10659203": { "compartment": "compartment_70101", "id": "reaction_10659203", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_113592" ], "products": [ "species_29370", "species_10659200" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10635272": { "compartment": "compartment_70101", "id": "reaction_10635272", "reactome": "R-CEL-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10635239" ], "products": [ "species_10635270" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10609396": { "compartment": "compartment_984", "id": "reaction_10609396", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609392" ], "products": [ "species_10609394", "species_10609268" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10611815": { "compartment": "compartment_13231", "id": "reaction_10611815", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611731" ], "products": [ "species_10611751" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666047": { "compartment": "compartment_263163", "id": "reaction_10666047", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_10666043" ], "products": [ "species_10666045" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "O01501", "WBGene00000871", "Q22895", "WBGene00004780", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "Q19213", "WBGene00006922", "O01501", "WBGene00000871", "Q03206", "ced-10", "Q22895", "WBGene00004780", "Q9BL44", "WBGene00022177", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "species_113592", "Q19213", "WBGene00006922", "Q94124", "WBGene00004287" ] }, "reaction_10611805": { "compartment": "compartment_17941", "id": "reaction_10611805", "reactome": "R-CEL-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611801" ], "products": [ "species_10611803", "species_10611729" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10641382": { "compartment": "compartment_70101", "id": "reaction_10641382", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641375", "species_10597908" ], "products": [ "species_10641379" ], "modifiers": [ [ "species_10641375", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00006727", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10634209": { "compartment": "compartment_876", "id": "reaction_10634209", "reactome": "R-CEL-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10634206" ], "products": [ "species_29370", "species_10629229" ], "modifiers": [ [ "species_10634206", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10648162": { "compartment": "compartment_7660", "id": "reaction_10648162", "reactome": "R-CEL-5687123", "name": "p-S115 MAPKAPK5 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648121" ], "products": [ "species_10648155" ], "modifiers": [], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647274": { "compartment": "compartment_876", "id": "reaction_10647274", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_29356" ], "products": [ "species_29372", "species_10647259" ], "modifiers": [ [ "species_10647271", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00012665" ] }, "reaction_10647211": { "compartment": "compartment_876", "id": "reaction_10647211", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647022", "species_113592" ], "products": [ "species_29370", "species_10647209" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10609410": { "compartment": "compartment_876", "id": "reaction_10609410", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10608501" ], "products": [ "species_10609408" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00005077", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10631282": { "compartment": "compartment_70101", "id": "reaction_10631282", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631254", "species_10597908" ], "products": [ "species_10631279" ], "modifiers": [ [ "species_10631254", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "WBGene00006727", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320" ] }, "reaction_10617626": { "compartment": "compartment_70101", "id": "reaction_10617626", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617621", "species_113592" ], "products": [ "species_29370", "species_10617623" ], "modifiers": [ [ "species_10617621", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665463": { "compartment": "compartment_876", "id": "reaction_10665463", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607827", "species_29420" ], "products": [ "species_10608583" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10639072": { "compartment": "compartment_171062", "id": "reaction_10639072", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639032" ], "products": [ "species_10638945" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10602395": { "compartment": "compartment_876", "id": "reaction_10602395", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602393" ], "products": [ "species_10602228" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10635619": { "compartment": "compartment_70101", "id": "reaction_10635619", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10609403": { "compartment": "compartment_70101", "id": "reaction_10609403", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609398" ], "products": [ "species_29370", "species_10609400" ], "modifiers": [ [ "species_10609398", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634137": { "compartment": "compartment_70101", "id": "reaction_10634137", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634134" ], "modifiers": [ [ "species_10627613", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10665363": { "compartment": "compartment_70101", "id": "reaction_10665363", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665353", "species_2530486" ], "products": [ "species_111294", "species_10665357" ], "modifiers": [ [ "species_10637128", "catalyst" ], [ "species_10665361", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10612224": { "compartment": "compartment_947587", "id": "reaction_10612224", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612218", "species_10611729" ], "products": [ "species_10612222" ], "modifiers": [], "additional_components": [ "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "G5EDS9", "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10630279": { "compartment": "compartment_70101", "id": "reaction_10630279", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10630276", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10647255": { "compartment": "compartment_876", "id": "reaction_10647255", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_10647073" ], "products": [ "species_10647075" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00018218", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10635261": { "compartment": "compartment_70101", "id": "reaction_10635261", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635225", "species_10635257" ], "products": [ "species_10635259" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q19404", "WBGene00008748" ] }, "reaction_10665609": { "compartment": "compartment_876", "id": "reaction_10665609", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607842", "species_10665605" ], "products": [ "species_10665607" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10665535": { "compartment": "compartment_876", "id": "reaction_10665535", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641023" ], "products": [ "species_10665533" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665386": { "compartment": "compartment_70101", "id": "reaction_10665386", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637128", "species_9653479" ], "products": [ "species_10665361" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10664082": { "compartment": "compartment_70101", "id": "reaction_10664082", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10659095": { "compartment": "compartment_70101", "id": "reaction_10659095", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_29356" ], "products": [ "species_10659088", "species_10622802", "species_29372" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664688": { "compartment": "compartment_13231", "id": "reaction_10664688", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664678" ], "products": [ "species_10614393" ], "modifiers": [ [ "species_10664686", "inhibitor" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P41990", "WBGene00000168" ] }, "reaction_10611757": { "compartment": "compartment_7660", "id": "reaction_10611757", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611751" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10665541": { "compartment": "compartment_70101", "id": "reaction_10665541", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642764", "species_10665537" ], "products": [ "species_10665539" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10657393": { "compartment": "compartment_876", "id": "reaction_10657393", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10657388", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10657407": { "compartment": "compartment_70101", "id": "reaction_10657407", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657404" ], "products": [ "species_10657402", "species_10605406", "species_29372" ], "modifiers": [ [ "species_10657404", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "WBGene00010374", "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10641386": { "compartment": "compartment_70101", "id": "reaction_10641386", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641379" ], "products": [ "species_10641373", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10642497": { "compartment": "compartment_70101", "id": "reaction_10642497", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642479" ], "products": [ "species_29370", "species_10642494" ], "modifiers": [ [ "species_10642479", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599" ] }, "reaction_10635268": { "compartment": "compartment_70101", "id": "reaction_10635268", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10658626": { "compartment": "compartment_984", "id": "reaction_10658626", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617340" ], "products": [ "species_10609274", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10666049": { "compartment": "compartment_263163", "id": "reaction_10666049", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10666037" ], "products": [ "species_10666039" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10624150": { "compartment": "compartment_876", "id": "reaction_10624150", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561049", "species_29406" ], "products": [ "species_561075", "species_561078" ], "modifiers": [ [ "species_10624147", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621694": { "compartment": "compartment_984", "id": "reaction_10621694", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10621687", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10621668": { "compartment": "compartment_876", "id": "reaction_10621668", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10621588": { "compartment": "compartment_876", "id": "reaction_10621588", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_374935" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10621585", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10621101": { "compartment": "compartment_876", "id": "reaction_10621101", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621098", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624015": { "compartment": "compartment_876", "id": "reaction_10624015", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10624012", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q23501", "WBGene00003843", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "A0A238UKL7", "WBGene00019408", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10620434": { "compartment": "compartment_876", "id": "reaction_10620434", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10620431", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10621605": { "compartment": "compartment_70101", "id": "reaction_10621605", "reactome": "R-CEL-444007", "name": "GAT1-3 mediate Na+/Cl- dependent GABA transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_188972", "species_74113" ], "products": [ "species_352011", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621602", "catalyst" ] ], "additional_components": [ "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623992": { "compartment": "compartment_876", "id": "reaction_10623992", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10623984", "catalyst" ], [ "species_10623990", "inhibitor" ] ], "additional_components": [ "WBGene00022348", "WBGene00004393" ] }, "reaction_10616675": { "compartment": "compartment_984", "id": "reaction_10616675", "reactome": "R-CEL-379393", "name": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_380873" ], "products": [ "species_159362", "species_83910" ], "modifiers": [ [ "species_10616672", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10616012": { "compartment": "compartment_876", "id": "reaction_10616012", "reactome": "R-CEL-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375468", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_375459" ], "modifiers": [ [ "species_10616009", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_29612", "CHEBI:58045", "CHEBI:16958", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "species_29432", "species_73590", "species_111707", "species_29612", "CHEBI:58045", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "WBGene00004908" ] }, "reaction_10624152": { "compartment": "compartment_876", "id": "reaction_10624152", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621636": { "compartment": "compartment_876", "id": "reaction_10621636", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10621633", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "WBGene00000295" ] }, "reaction_10621682": { "compartment": "compartment_876", "id": "reaction_10621682", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10624222": { "compartment": "compartment_876", "id": "reaction_10624222", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10624219", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621616": { "compartment": "compartment_876", "id": "reaction_10621616", "reactome": "R-CEL-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113", "species_188972" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10611405", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10621045": { "compartment": "compartment_876", "id": "reaction_10621045", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10621042", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10624050": { "compartment": "compartment_876", "id": "reaction_10624050", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621088": { "compartment": "compartment_876", "id": "reaction_10621088", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433138" ], "products": [ "species_83910", "species_76190" ], "modifiers": [ [ "species_10621085", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10615145": { "compartment": "compartment_876", "id": "reaction_10615145", "reactome": "R-CEL-351987", "name": "SLC6A6-mediated uptake of taurine and beta-alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352024", "species_74113", "species_188972" ], "products": [ "species_352019", "species_83910", "species_352022" ], "modifiers": [ [ "species_10615142", "catalyst" ] ], "additional_components": [ "CHEBI:16958", "CHEBI:15891", "species_73590", "CHEBI:15891", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10624048": { "compartment": "compartment_876", "id": "reaction_10624048", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621083": { "compartment": "compartment_876", "id": "reaction_10621083", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433123" ], "products": [ "species_83910", "species_29434" ], "modifiers": [ [ "species_10621080", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10623957": { "compartment": "compartment_876", "id": "reaction_10623957", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622172": { "compartment": "compartment_876", "id": "reaction_10622172", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10621070": { "compartment": "compartment_876", "id": "reaction_10621070", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621067", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624187": { "compartment": "compartment_876", "id": "reaction_10624187", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561071", "species_29406" ], "products": [ "species_561075", "species_561062" ], "modifiers": [ [ "species_10624184", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176496", "species_176501", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10615148": { "compartment": "compartment_876", "id": "reaction_10615148", "reactome": "R-CEL-352029", "name": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_352007" ], "products": [ "species_83910", "species_352022", "species_351982" ], "modifiers": [ [ "species_10611378", "catalyst" ] ], "additional_components": [ "CHEBI:48950", "CHEBI:16958", "species_352003", "species_6798202", "species_73590", "CHEBI:48950", "species_352003", "species_6798202", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623996": { "compartment": "compartment_876", "id": "reaction_10623996", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621631": { "compartment": "compartment_876", "id": "reaction_10621631", "reactome": "R-CEL-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029", "species_74113", "species_188972" ], "products": [ "species_29424", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621628", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10624189": { "compartment": "compartment_876", "id": "reaction_10624189", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621119": { "compartment": "compartment_876", "id": "reaction_10621119", "reactome": "R-CEL-433698", "name": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10621116", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10624243": { "compartment": "compartment_876", "id": "reaction_10624243", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_597604" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10624240", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "WBGene00008273" ] }, "reaction_10615811": { "compartment": "compartment_876", "id": "reaction_10615811", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622170": { "compartment": "compartment_876", "id": "reaction_10622170", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10620466": { "compartment": "compartment_876", "id": "reaction_10620466", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_264618" ], "modifiers": [ [ "species_10620463", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10621677": { "compartment": "compartment_876", "id": "reaction_10621677", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10665294": { "compartment": "compartment_876", "id": "reaction_10665294", "reactome": "R-CEL-9645220", "name": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10665291", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10621114": { "compartment": "compartment_876", "id": "reaction_10621114", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433111" ], "products": [ "species_433124", "species_83910" ], "modifiers": [ [ "species_10621111", "catalyst" ] ], "additional_components": [ "species_29654", "species_1650769", "species_29654", "species_1650769", "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10612194": { "compartment": "compartment_70101", "id": "reaction_10612194", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612187", "species_179856" ], "products": [ "species_10612192" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10612202": { "compartment": "compartment_70101", "id": "reaction_10612202", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10612199", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10625850": { "compartment": "compartment_74700", "id": "reaction_10625850", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10625847", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10625825": { "compartment": "compartment_74700", "id": "reaction_10625825", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10598971": { "compartment": "compartment_5460", "id": "reaction_10598971", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10598968", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10599029": { "compartment": "compartment_5460", "id": "reaction_10599029", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10599026", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10598935": { "compartment": "compartment_5460", "id": "reaction_10598935", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10598932", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57427", "species_29702", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10599039": { "compartment": "compartment_5460", "id": "reaction_10599039", "reactome": "R-CEL-70885", "name": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_573404", "species_113526" ], "products": [ "species_29362", "species_113529", "species_30004" ], "modifiers": [ [ "species_10599036", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10623795": { "compartment": "compartment_5460", "id": "reaction_10623795", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10598958", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10623787": { "compartment": "compartment_70101", "id": "reaction_10623787", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_508182", "species_29406" ], "modifiers": [ [ "species_10598916", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "CHEBI:58045", "CHEBI:57427", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10598991": { "compartment": "compartment_5460", "id": "reaction_10598991", "reactome": "R-CEL-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10598988", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10599011": { "compartment": "compartment_5460", "id": "reaction_10599011", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10599008", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10599001": { "compartment": "compartment_5460", "id": "reaction_10599001", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10599021": { "compartment": "compartment_5460", "id": "reaction_10599021", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10598945": { "compartment": "compartment_5460", "id": "reaction_10598945", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10598942", "catalyst" ] ], "additional_components": [ "species_113596", "G5EEH6", "WBGene00015326" ] }, "reaction_10598908": { "compartment": "compartment_5460", "id": "reaction_10598908", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10598905", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O17953", "WBGene00010794", "O45924", "WBGene00012713", "species_113596" ] }, "reaction_10598981": { "compartment": "compartment_5460", "id": "reaction_10598981", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10598978", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10599047": { "compartment": "compartment_5460", "id": "reaction_10599047", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599044", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10648280": { "compartment": "compartment_70101", "id": "reaction_10648280", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607380" ], "products": [ "species_10607378", "species_10607380" ], "modifiers": [ [ "species_10648277", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10648264": { "compartment": "compartment_7660", "id": "reaction_10648264", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648253", "species_10648260" ], "products": [ "species_10648262" ], "modifiers": [], "additional_components": [ "WBGene00013924", "WBGene00006446", "O17850", "WBGene00006446", "Q23451", "WBGene00013924" ] }, "reaction_10649878": { "compartment": "compartment_7660", "id": "reaction_10649878", "reactome": "R-CEL-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649863" ], "products": [ "species_10649875", "species_10648387" ], "modifiers": [ [ "species_10649863", "catalyst" ] ], "additional_components": [ "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "P0CG71", "WBGene00006727", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249" ] }, "reaction_10649549": { "compartment": "compartment_7660", "id": "reaction_10649549", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649544" ], "products": [ "species_10648387", "species_10649546" ], "modifiers": [ [ "species_10649544", "catalyst" ] ], "additional_components": [ "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10649902": { "compartment": "compartment_7660", "id": "reaction_10649902", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607906", "species_10649898" ], "products": [ "species_10649900" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "P46504", "WBGene00017754", "Q20617", "WBGene00006719", "Q9XVR6", "WBGene00007718", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10659851": { "compartment": "compartment_70101", "id": "reaction_10659851", "reactome": "R-CEL-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659849" ], "products": [ "species_10611220" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00001112" ] }, "reaction_10646598": { "compartment": "compartment_70101", "id": "reaction_10646598", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646587", "species_10646594" ], "products": [ "species_10646596" ], "modifiers": [], "additional_components": [ "WBGene00006724", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q09444", "WBGene00006724", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648301": { "compartment": "compartment_70101", "id": "reaction_10648301", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648297", "species_10646594" ], "products": [ "species_10648299" ], "modifiers": [], "additional_components": [ "WBGene00006856", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "Q17361", "WBGene00006856", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648390": { "compartment": "compartment_7660", "id": "reaction_10648390", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648346" ], "products": [ "species_10648387", "species_10648352" ], "modifiers": [ [ "species_10648346", "catalyst" ] ], "additional_components": [ "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "P0CG71", "WBGene00006727", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912" ] }, "reaction_10649596": { "compartment": "compartment_7660", "id": "reaction_10649596", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649591" ], "products": [ "species_10649593", "species_10648387" ], "modifiers": [ [ "species_10649591", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10658620": { "compartment": "compartment_70101", "id": "reaction_10658620", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648512" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10658617", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00021733" ] }, "reaction_10648492": { "compartment": "compartment_7660", "id": "reaction_10648492", "reactome": "R-CEL-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648487", "species_113518" ], "products": [ "species_10648489", "species_10597874" ], "modifiers": [ [ "species_10648487", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10648531": { "compartment": "compartment_70101", "id": "reaction_10648531", "reactome": "R-CEL-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10648504" ], "products": [ "species_10648506", "species_10648528" ], "modifiers": [ [ "species_10648504", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400" ] }, "reaction_10649660": { "compartment": "compartment_7660", "id": "reaction_10649660", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649653" ], "products": [ "species_10649657", "species_10648387" ], "modifiers": [ [ "species_10649653", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863" ] }, "reaction_10649710": { "compartment": "compartment_70101", "id": "reaction_10649710", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649706", "species_10628847" ], "products": [ "species_10649708" ], "modifiers": [], "additional_components": [ "WBGene00008547", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q19132", "WBGene00008547" ] }, "reaction_10648284": { "compartment": "compartment_7660", "id": "reaction_10648284", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646315", "species_10648260" ], "products": [ "species_10648282" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "P54812", "WBGene00008053", "O17850", "WBGene00006446" ] }, "reaction_10648649": { "compartment": "compartment_70101", "id": "reaction_10648649", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648645", "species_10648641" ], "products": [ "species_10648647" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "O76671", "WBGene00019185", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "Q22038", "WBGene00004357", "P46504", "WBGene00017754", "O76671", "WBGene00019185", "Q9XVR6", "WBGene00007718" ] }, "reaction_10646629": { "compartment": "compartment_70101", "id": "reaction_10646629", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646592", "species_10598108" ], "products": [ "species_10646594" ], "modifiers": [], "additional_components": [ "WBGene00016981", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648625": { "compartment": "compartment_70101", "id": "reaction_10648625", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648616", "species_29356" ], "products": [ "species_10648620", "species_10648622" ], "modifiers": [ [ "species_10648616", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10649635": { "compartment": "compartment_7660", "id": "reaction_10649635", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649630" ], "products": [ "species_10649632", "species_10597874" ], "modifiers": [ [ "species_10649630", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "WBGene00006727", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885" ] }, "reaction_10649701": { "compartment": "compartment_70101", "id": "reaction_10649701", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649694", "species_29356" ], "products": [ "species_10649698", "species_10597908" ], "modifiers": [ [ "species_10649694", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "WBGene00006727", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856" ] }, "reaction_10648584": { "compartment": "compartment_70101", "id": "reaction_10648584", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648579", "species_29356" ], "products": [ "species_1131871", "species_10648581" ], "modifiers": [ [ "species_10648579", "catalyst" ] ], "additional_components": [ "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727" ] }, "reaction_10656887": { "compartment": "compartment_263163", "id": "reaction_10656887", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656855", "species_10656885" ], "products": [ "species_10656865" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10657132": { "compartment": "compartment_263163", "id": "reaction_10657132", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657128" ], "products": [ "species_10657130" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O18230", "WBGene00013302", "Q94392", "WBGene00003818" ] }, "reaction_10656916": { "compartment": "compartment_70101", "id": "reaction_10656916", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656912", "species_10656873" ], "products": [ "species_10656914" ], "modifiers": [], "additional_components": [ "WBGene00010040", "Q20758", "WBGene00000187", "species_29438", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10656741": { "compartment": "compartment_263163", "id": "reaction_10656741", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10656732" ], "products": [ "species_10656738", "species_29420" ], "modifiers": [ [ "species_10656732", "catalyst" ] ], "additional_components": [ "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "species_29438", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656881": { "compartment": "compartment_263163", "id": "reaction_10656881", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656865", "species_10656873" ], "products": [ "species_10656879" ], "modifiers": [], "additional_components": [ "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10656734": { "compartment": "compartment_263163", "id": "reaction_10656734", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656722", "species_10656710" ], "products": [ "species_10656732" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656925": { "compartment": "compartment_70101", "id": "reaction_10656925", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656921", "species_10656873" ], "products": [ "species_10656923" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10656907": { "compartment": "compartment_263163", "id": "reaction_10656907", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656903", "species_10656879" ], "products": [ "species_10656905" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q9N3C8", "WBGene00021841", "Q18013", "WBGene00002220", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10651166": { "compartment": "compartment_7660", "id": "reaction_10651166", "reactome": "R-CEL-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651163", "species_113560" ], "products": [ "species_2485002", "species_10647489" ], "modifiers": [ [ "species_10651163", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647505": { "compartment": "compartment_7660", "id": "reaction_10647505", "reactome": "R-CEL-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647500", "species_113560" ], "products": [ "species_2485002", "species_10647502" ], "modifiers": [ [ "species_10647500", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647494": { "compartment": "compartment_7660", "id": "reaction_10647494", "reactome": "R-CEL-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647489", "species_29358" ], "products": [ "species_113582", "species_10647491", "species_10614888" ], "modifiers": [ [ "species_10647489", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648887": { "compartment": "compartment_7660", "id": "reaction_10648887", "reactome": "R-CEL-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647502", "species_29358" ], "products": [ "species_113582", "species_10648884", "species_10614888" ], "modifiers": [ [ "species_10647502", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10603971": { "compartment": "compartment_5460", "id": "reaction_10603971", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603969": { "compartment": "compartment_5460", "id": "reaction_10603969", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77322" ], "products": [ "species_29362", "species_77320", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603967": { "compartment": "compartment_5460", "id": "reaction_10603967", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10649824": { "compartment": "compartment_7660", "id": "reaction_10649824", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10649819" ], "products": [ "species_10649821", "species_113541" ], "modifiers": [ [ "species_10649819", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823" ] }, "reaction_10649832": { "compartment": "compartment_7660", "id": "reaction_10649832", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649821" ], "products": [ "species_10649830", "species_10648549" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "WBGene00002985" ] }, "reaction_10614353": { "compartment": "compartment_7660", "id": "reaction_10614353", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614344", "species_77087" ], "products": [ "species_77502", "species_10614350" ], "modifiers": [ [ "species_10614344", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9GYS1", "WBGene00003224", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614340": { "compartment": "compartment_7660", "id": "reaction_10614340", "reactome": "R-CEL-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10614318" ], "products": [ "species_10614337", "species_77502" ], "modifiers": [ [ "species_10614318", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614320": { "compartment": "compartment_7660", "id": "reaction_10614320", "reactome": "R-CEL-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10614316" ], "products": [ "species_10614318" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10660998": { "compartment": "compartment_7660", "id": "reaction_10660998", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10638301" ], "products": [ "species_10660996" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00003599", "H2L0K3", "WBGene00003599", "G5EFQ5", "WBGene00004393" ] }, "reaction_10658639": { "compartment": "compartment_7660", "id": "reaction_10658639", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10658633" ], "products": [ "species_10658637" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10666150": { "compartment": "compartment_12045", "id": "reaction_10666150", "reactome": "R-CEL-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10617216" ], "products": [ "species_10617224" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10637461": { "compartment": "compartment_984", "id": "reaction_10637461", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637458", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q19777", "WBGene00009109" ] }, "reaction_10666201": { "compartment": "compartment_876", "id": "reaction_10666201", "reactome": "R-CEL-9728748", "name": "Bitter compound binds bitter taste receptor (TAS2R)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666195", "species_9728981" ], "products": [ "species_10666199" ], "modifiers": [], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "CHEBI:73236", "CHEBI:10093", "CHEBI:9162", "CHEBI:351346", "CHEBI:7789", "LigandDisplayForward?ligandId=5535", "CHEBI:3768", "CHEBI:73226", "CHEBI:5547", "CHEBI:73235", "LigandDisplayForward?ligandId=7074", "CHEBI:2948", "CHEBI:2366", "CHEBI:73222", "CHEBI:44975", "CHEBI:23736", "CHEBI:3941", "pubchem.compound:14217", "CHEBI:8206", "CHEBI:138412", "LigandDisplayForward?ligandId=86", "CHEBI:27641", "pubchem.compound:3032338", "pubchem.compound:19518", "CHEBI:4325", "pubchem.compound:69794", "CHEBI:32111", "CHEBI:3419", "CHEBI:34750", "CHEBI:36773", "CHEBI:73237", "CHEBI:73224", "CHEBI:27613", "CHEBI:2825", "CHEBI:82431", "species_39703", "pubchem.compound:2723704", "CHEBI:42638", "species_76328", "CHEBI:17814", "CHEBI:69441", "species_8855492", "CHEBI:2853", "CHEBI:82346", "CHEBI:28179", "LigandDisplayForward?ligandId=1224", "LigandDisplayForward?ligandId=6976", "CHEBI:26948", "CHEBI:83501", "CHEBI:59039", "CHEBI:46261", "CHEBI:3445", "CHEBI:3944", "CHEBI:28973", "CHEBI:16150", "CHEBI:73232", "CHEBI:18305", "CHEBI:28579", "CHEBI:15854", "CHEBI:3614", "CHEBI:8502", "CHEBI:17698", "pubchem.compound:71648", "CHEBI:69236", "CHEBI:2622", "CHEBI:8692", "CHEBI:4638", "CHEBI:73239", "species_39427", "CHEBI:23359", "CHEBI:28241", "CHEBI:48923", "CHEBI:73228", "CHEBI:17682", "CHEBI:16226", "CHEBI:65408", "CHEBI:7939", "CHEBI:3193", "pubchem.compound:2723593", "species_217315", "CHEBI:27732", "CHEBI:73231", "CHEBI:16962", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678" ] }, "reaction_10666153": { "compartment": "compartment_12045", "id": "reaction_10666153", "reactome": "R-CEL-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10617224", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10660101": { "compartment": "compartment_70101", "id": "reaction_10660101", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_8876310" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10660098", "catalyst" ] ], "additional_components": [ "species_8869604", "species_113557", "species_6807616", "species_197230", "species_113557", "species_6807616", "WBGene00014092" ] }, "reaction_10620062": { "compartment": "compartment_876", "id": "reaction_10620062", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10620059", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10619969": { "compartment": "compartment_876", "id": "reaction_10619969", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10619966", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10645786": { "compartment": "compartment_70101", "id": "reaction_10645786", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10645783", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10618811": { "compartment": "compartment_876", "id": "reaction_10618811", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10618808", "catalyst" ] ], "additional_components": [ "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151", "Q95XP5", "WBGene00003153" ] }, "reaction_10618823": { "compartment": "compartment_114521", "id": "reaction_10618823", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_427899" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10618816", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10619486": { "compartment": "compartment_876", "id": "reaction_10619486", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10619483", "catalyst" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "H2KYP2", "WBGene00003567", "G5EF08", "WBGene00003566", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10618036": { "compartment": "compartment_70101", "id": "reaction_10618036", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618031" ], "products": [ "species_29420", "species_10618033" ], "modifiers": [ [ "species_10618031", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10614196": { "compartment": "compartment_7660", "id": "reaction_10614196", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10614200": { "compartment": "compartment_7660", "id": "reaction_10614200", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10636661": { "compartment": "compartment_70101", "id": "reaction_10636661", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357697", "species_5359016" ], "products": [ "species_5357660", "species_5359011", "species_29432" ], "modifiers": [ [ "species_10636658", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10631233": { "compartment": "compartment_70101", "id": "reaction_10631233", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10631230", "catalyst" ] ], "additional_components": [ "Q22820", "WBGene00000515", "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631053": { "compartment": "compartment_12045", "id": "reaction_10631053", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10631050", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "O44732", "WBGene00018797", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631200": { "compartment": "compartment_12045", "id": "reaction_10631200", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10631197", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10649500": { "compartment": "compartment_5460", "id": "reaction_10649500", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696414" ], "products": [ "species_113548", "species_5693978", "species_113532" ], "modifiers": [ [ "species_10649497", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10631211": { "compartment": "compartment_12045", "id": "reaction_10631211", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10631208", "catalyst" ] ], "additional_components": [ "Q9XXT5", "WBGene00010425", "species_109496" ] }, "reaction_10649269": { "compartment": "compartment_12045", "id": "reaction_10649269", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612768", "species_10612734" ], "products": [ "species_10612770" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "G5EDE8", "WBGene00002070", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q22170", "WBGene00002071" ] }, "reaction_10649279": { "compartment": "compartment_12045", "id": "reaction_10649279", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612677", "species_10612714" ], "products": [ "species_10612716" ], "modifiers": [], "additional_components": [ "WBGene00011648", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615" ] }, "reaction_10657200": { "compartment": "compartment_6791047", "id": "reaction_10657200", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657195" ], "products": [ "species_10649098", "species_10657193" ], "modifiers": [ [ "species_10657195", "catalyst" ] ], "additional_components": [ "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "species_29420", "Q9UAQ6", "WBGene00004266", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649271": { "compartment": "compartment_13959", "id": "reaction_10649271", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649098", "species_10612881", "species_10649147" ], "products": [ "species_10649149" ], "modifiers": [], "additional_components": [ "species_29420", "Q9UAQ6", "WBGene00004266", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "O02173", "WBGene00021046", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649264": { "compartment": "compartment_6791047", "id": "reaction_10649264", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10649260" ], "products": [ "species_10649262" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10612886": { "compartment": "compartment_13959", "id": "reaction_10612886", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612785" ], "products": [ "species_10612883", "species_10612622", "species_10612781", "species_29372", "species_10612881" ], "modifiers": [ [ "species_10612785", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "WBGene00022678", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10657197": { "compartment": "compartment_6791047", "id": "reaction_10657197", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10657193" ], "products": [ "species_10657195" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649386": { "compartment": "compartment_12045", "id": "reaction_10649386", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612772", "species_10612652", "species_10612904" ], "products": [ "species_10612774" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10612896": { "compartment": "compartment_70101", "id": "reaction_10612896", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10612888" ], "products": [ "species_10612652", "species_29420" ], "modifiers": [ [ "species_10612893", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "species_29438", "Q23445", "WBGene00022678", "WBGene00010496" ] }, "reaction_10649171": { "compartment": "compartment_12045", "id": "reaction_10649171", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612898", "species_10612598", "species_10612670" ], "products": [ "species_10649169" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853" ] }, "reaction_10649345": { "compartment": "compartment_6791047", "id": "reaction_10649345", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649252", "species_10649277" ], "products": [ "species_10649343", "species_10649179", "species_10649260", "species_10649186" ], "modifiers": [], "additional_components": [ "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "G5EGG0", "WBGene00010713" ] }, "reaction_10649267": { "compartment": "compartment_6791047", "id": "reaction_10649267", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10649262" ], "products": [ "species_10649229", "species_10649241", "species_10649213", "species_10649258", "species_10649250", "species_10649236", "species_29372", "species_10649234" ], "modifiers": [ [ "species_10649262", "catalyst" ] ], "additional_components": [ "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00009654", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "Q9TXZ9", "WBGene00015164", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "WBGene00007128", "WBGene00043064", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10649156": { "compartment": "compartment_13959", "id": "reaction_10649156", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649149", "species_29438" ], "products": [ "species_10649153", "species_29420" ], "modifiers": [ [ "species_10649149", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649194": { "compartment": "compartment_20699", "id": "reaction_10649194", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649179", "species_10649153", "species_10649186" ], "products": [ "species_10649192" ], "modifiers": [], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "G5EGG0", "WBGene00010713", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649173": { "compartment": "compartment_12045", "id": "reaction_10649173", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774", "species_10612622", "species_10612781" ], "products": [ "species_10612783" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649389": { "compartment": "compartment_70101", "id": "reaction_10649389", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774" ], "products": [ "species_10612772", "species_10612888", "species_29372", "species_10612904" ], "modifiers": [ [ "species_10612774", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29420", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649167": { "compartment": "compartment_12045", "id": "reaction_10649167", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612664", "species_10612670", "species_10612666" ], "products": [ "species_10612672" ], "modifiers": [], "additional_components": [ "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "WBGene00004754", "WBGene00004755", "Q19371", "WBGene00004755", "Q20797", "WBGene00006373", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128" ] }, "reaction_10618547": { "compartment": "compartment_876", "id": "reaction_10618547", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618543", "species_10618528" ], "products": [ "species_10618545" ], "modifiers": [], "additional_components": [ "Q966F9", "WBGene00000071", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q966F9", "WBGene00000071" ] }, "reaction_10618534": { "compartment": "compartment_876", "id": "reaction_10618534", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10618532": { "compartment": "compartment_876", "id": "reaction_10618532", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618530" ], "products": [ "species_10618522", "species_10618528" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618540": { "compartment": "compartment_876", "id": "reaction_10618540", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618538" ], "products": [ "species_10618530", "species_29420" ], "modifiers": [ [ "species_10616742", "catalyst" ] ], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10664419": { "compartment": "compartment_17963", "id": "reaction_10664419", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9033793", "species_205689" ], "modifiers": [ [ "species_10664416", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664437": { "compartment": "compartment_17963", "id": "reaction_10664437", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_9037036", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10656475": { "compartment": "compartment_7660", "id": "reaction_10656475", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10656463" ], "products": [ "species_113582", "species_10656472" ], "modifiers": [ [ "species_10656463", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657117": { "compartment": "compartment_7660", "id": "reaction_10657117", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_29470", "species_29358", "species_113562", "species_10657112" ], "products": [ "species_10657114" ], "modifiers": [ [ "species_10657112", "catalyst" ], [ "species_10657112", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994" ] }, "reaction_10656512": { "compartment": "compartment_7660", "id": "reaction_10656512", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599971", "species_10656465" ], "products": [ "species_10656463" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "Q7YTH5", "WBGene00006390", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "P91868", "WBGene00001568", "G5EG47", "WBGene00010054", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657106": { "compartment": "compartment_7660", "id": "reaction_10657106", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657090" ], "products": [ "species_10657098", "species_10657092" ], "modifiers": [ [ "species_10657090", "catalyst" ], [ "species_10657104", "catalyst" ], [ "species_10600765", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "species_430042", "Q966L5", 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"H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "WBGene00020480", "WBGene00020092" ] }, "reaction_10657202": { "compartment": "compartment_7660", "id": "reaction_10657202", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610160", "species_10600248", "species_10657114", "species_10599886" ], "products": [ "species_10657090" ], "modifiers": [], "additional_components": [ "WBGene00022192", "WBGene00017085", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085" ] }, "reaction_10656510": { "compartment": "compartment_7660", "id": "reaction_10656510", "reactome": "R-CEL-6810235", "name": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656480", "species_10656472", "species_10656504", "species_10656498" ], "products": [ "species_10656508" ], "modifiers": [], "additional_components": [ "WBGene00011143", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "A5Z2V1", "WBGene00009451", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10640732": { "compartment": "compartment_70101", "id": "reaction_10640732", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640717" ], "products": [ "species_29370", "species_10640729" ], "modifiers": [ [ "species_10640717", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640614": { "compartment": "compartment_876", "id": "reaction_10640614", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640606", "species_179856" ], "products": [ "species_10640608" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532" ] }, "reaction_10640600": { "compartment": "compartment_70101", "id": "reaction_10640600", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640597", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95YD4", "WBGene00002213", "Q19475", "WBGene00001164", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10640694": { "compartment": "compartment_70101", "id": "reaction_10640694", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640690", "species_10640684" ], "products": [ "species_10640692" ], "modifiers": [], "additional_components": [ "WBGene00008805", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640702": { "compartment": "compartment_876", "id": "reaction_10640702", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613333", "species_10617725" ], "products": [ "species_10640700" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q17850", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640833": { "compartment": "compartment_70101", "id": "reaction_10640833", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640743", "species_10613352" ], "products": [ "species_10640745" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "WBGene00015704", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640998": { "compartment": "compartment_876", "id": "reaction_10640998", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640991" ], "products": [ "species_10640996" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10640764": { "compartment": "compartment_70101", "id": "reaction_10640764", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621901", "species_113592" ], "products": [ "species_29370", "species_10622006" ], "modifiers": [ [ "species_10640729", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640612": { "compartment": "compartment_876", "id": "reaction_10640612", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10633823", "species_10640608" ], "products": [ "species_10640610" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "Q19475", "WBGene00001164", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "O61861", "WBGene00000205", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10640761": { "compartment": "compartment_876", "id": "reaction_10640761", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331", "species_10640711" ], "products": [ "species_10640713", "species_114549" ], "modifiers": [ [ "species_10640711", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640709": { "compartment": "compartment_70101", "id": "reaction_10640709", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640700" ], "products": [ "species_29370", "species_10640706" ], "modifiers": [ [ "species_10640700", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640753": { "compartment": "compartment_70101", "id": "reaction_10640753", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640745", "species_113592" ], "products": [ "species_29370", "species_10640750" ], "modifiers": [ [ "species_10640745", "catalyst" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640994": { "compartment": "compartment_876", "id": "reaction_10640994", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640750", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640758": { "compartment": "compartment_70101", "id": "reaction_10640758", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608729", "species_10640692" ], "products": [ "species_10640711" ], "modifiers": [], "additional_components": [ "WBGene00010776", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640766": { "compartment": "compartment_70101", "id": "reaction_10640766", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640715", "species_10640713" ], "products": [ "species_10640717" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640841": { "compartment": "compartment_876", "id": "reaction_10640841", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640838", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q965J0", "WBGene00019487", "Q19475", "WBGene00001164" ] }, "reaction_10665741": { "compartment": "compartment_7660", "id": "reaction_10665741", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606498", "species_10665737" ], "products": [ "species_10665739" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "O17919", "WBGene00010478", "Q9TYM6", "WBGene00021655" ] }, "reaction_10642188": { "compartment": "compartment_12045", "id": "reaction_10642188", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642180" ], "products": [ "species_10642077" ], "modifiers": [ [ "species_10642185", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00010757" ] }, "reaction_10625508": { "compartment": "compartment_17963", "id": "reaction_10625508", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625506", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625528": { "compartment": "compartment_17963", "id": "reaction_10625528", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625526", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625518": { "compartment": "compartment_17963", "id": "reaction_10625518", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_205687", "species_10625516" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10634243": { "compartment": "compartment_17963", "id": "reaction_10634243", "reactome": "R-CEL-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625526" ], "products": [ "species_10634238", "species_205687" ], "modifiers": [ [ "species_10634240", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10625644": { "compartment": "compartment_17963", "id": "reaction_10625644", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625415" ], "products": [ "species_205687", "species_10625642" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625551": { "compartment": "compartment_20699", "id": "reaction_10625551", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_205687", "species_10625536" ], "modifiers": [ [ "species_10625548", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q20575", "WBGene00009849", "Q19421", "WBGene00008766" ] }, "reaction_10625655": { "compartment": "compartment_20699", "id": "reaction_10625655", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625536", "species_914003" ], "products": [ "species_205687", "species_10625652" ], "modifiers": [ [ "species_10625601", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10642136": { "compartment": "compartment_12045", "id": "reaction_10642136", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10642077" ], "products": [ "species_158602", "species_10642128" ], "modifiers": [ [ "species_10642133", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00022576" ] }, "reaction_10625634": { "compartment": "compartment_17963", "id": "reaction_10625634", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625559", "species_914003" ], "products": [ "species_10625567", "species_205687" ], "modifiers": [ [ "species_10625631", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641", "G5EBK7", "WBGene00001644", "G5ECK8", "WBGene00001626", "G5EEZ8", "WBGene00001640", "O02315", "WBGene00001642" ] }, "reaction_10625482": { "compartment": "compartment_20699", "id": "reaction_10625482", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625407" ], "products": [ "species_205687", "species_10625415" ], "modifiers": [ [ "species_10625479", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34678", "WBGene00001628", "Q9U2C4", "WBGene00012934", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "O45293", "WBGene00001633", "Q7K755", "WBGene00001636", "O45947", "WBGene00001635", "O61397", "WBGene00001632" ] }, "reaction_10634322": { "compartment": "compartment_20699", "id": "reaction_10634322", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_10625559", "species_205687" ], "modifiers": [ [ "species_10634319", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "O17747", "WBGene00021403", "O17053", "WBGene00021403", "O45579", "WBGene00021403", "O44563", "WBGene00044620", "G5ECT3", "WBGene00021403", "Q22900", "WBGene00021403", "O18184", "WBGene00021403", "Q18515", "WBGene00021403", "O16535", "WBGene00021403", "P41881", "WBGene00021403" ] }, "reaction_10629081": { "compartment": "compartment_24339", "id": "reaction_10629081", "reactome": "R-CEL-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629043" ], "products": [ "species_10629079" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629007": { "compartment": "compartment_171043", "id": "reaction_10629007", "reactome": "R-CEL-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629005" ], "products": [ "species_1236715", "species_10629003" ], "modifiers": [], "additional_components": [ "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629097": { "compartment": "compartment_21994", "id": "reaction_10629097", "reactome": "R-CEL-1236956", "name": "Engulfment of particulate antigen into phagocytic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629089" ], "products": [ "species_10629095", "species_1236714" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10629101": { "compartment": "compartment_70101", "id": "reaction_10629101", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10629083": { "compartment": "compartment_24339", "id": "reaction_10629083", "reactome": "R-CEL-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629079" ], "products": [ "species_10629005" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629099": { "compartment": "compartment_876", "id": "reaction_10629099", "reactome": "R-CEL-1236958", "name": "Interaction of particulate antigens with dendritic cell receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236726", "species_10629087" ], "products": [ "species_10629089" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10649526": { "compartment": "compartment_12045", "id": "reaction_10649526", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10631021": { "compartment": "compartment_12045", "id": "reaction_10631021", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10631018", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910", "Q9NCE1", "WBGene00010408" ] }, "reaction_10630954": { "compartment": "compartment_12045", "id": "reaction_10630954", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657376": { "compartment": "compartment_12045", "id": "reaction_10657376", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10657373", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10630989": { "compartment": "compartment_12045", "id": "reaction_10630989", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630956": { "compartment": "compartment_12045", "id": "reaction_10630956", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630975": { "compartment": "compartment_12045", "id": "reaction_10630975", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500594", "species_29356" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10636052": { "compartment": "compartment_70101", "id": "reaction_10636052", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_265283" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636055": { "compartment": "compartment_70101", "id": "reaction_10636055", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636060": { "compartment": "compartment_70101", "id": "reaction_10636060", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10636057", "catalyst" ] ], "additional_components": [ "Q09596", "WBGene00001753", "species_29450" ] }, "reaction_10614716": { "compartment": "compartment_70101", "id": "reaction_10614716", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10614713", "catalyst" ] ], "additional_components": [ "Q23280", "WBGene00022599", "Q21925", "WBGene00011239" ] }, "reaction_10661537": { "compartment": "compartment_70616", "id": "reaction_10661537", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10661534", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661604": { "compartment": "compartment_70616", "id": "reaction_10661604", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661580", "species_10661578" ], "products": [ "species_10661582" ], "modifiers": [], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10662558": { "compartment": "compartment_70616", "id": "reaction_10662558", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523", "species_10661513", "species_10661532", "species_10661518", "species_10661511" ], "products": [ "species_10661534" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00019296", "Q18874", "WBGene00008345", "WBGene00013462", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661609": { "compartment": "compartment_70616", "id": "reaction_10661609", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949220", "species_2889072" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10661606", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10661599": { "compartment": "compartment_70616", "id": "reaction_10661599", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661582" ], "products": [ "species_10661523", "species_10661578", "species_10661584" ], "modifiers": [ [ "species_10661596", "catalyst" ] ], "additional_components": [ "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "Q23295", "WBGene00013880", "Q95XN2", "WBGene00022159" ] }, "reaction_10661602": { "compartment": "compartment_70616", "id": "reaction_10661602", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523" ], "products": [], "modifiers": [ [ "species_10661578", "catalyst" ] ], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10601291": { "compartment": "compartment_70101", "id": "reaction_10601291", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601287", "species_10601248" ], "products": [ "species_10601289" ], "modifiers": [], "additional_components": [ "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560" ] }, "reaction_10601565": { "compartment": "compartment_70101", "id": "reaction_10601565", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601289" ], "products": [ "species_10601199", "species_10601287", "species_29420" ], "modifiers": [ [ "species_10601287", "catalyst" ] ], "additional_components": [ "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950" ] }, "reaction_10603965": { "compartment": "compartment_5460", "id": "reaction_10603965", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603963": { "compartment": "compartment_5460", "id": "reaction_10603963", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77251", "species_113526" ], "products": [ "species_73871", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10644252": { "compartment": "compartment_876", "id": "reaction_10644252", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644249", "catalyst" ] ], "additional_components": [ "A0A4V0IK35", "WBGene00015867", "O45313", "WBGene00008307", "Q95XD1", "WBGene00022240", "O16638", "WBGene00021116" ] }, "reaction_10664085": { "compartment": "compartment_70101", "id": "reaction_10664085", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664090": { "compartment": "compartment_70101", "id": "reaction_10664090", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_9020474", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10618717": { "compartment": "compartment_876", "id": "reaction_10618717", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618713" ], "products": [ "species_10618715" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10618705": { "compartment": "compartment_984", "id": "reaction_10618705", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618695" ], "products": [ "species_10618703" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10621227": { "compartment": "compartment_876", "id": "reaction_10621227", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621223", "species_10621215" ], "products": [ "species_10621225" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615528": { "compartment": "compartment_876", "id": "reaction_10615528", "reactome": "R-CEL-373746", "name": "SEMA4D interacts with CD45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615507", "species_10615524" ], "products": [ "species_10615526" ], "modifiers": [], "additional_components": [ "WBGene00009401", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q20019", "WBGene00009401" ] }, "reaction_10604168": { "compartment": "compartment_7660", "id": "reaction_10604168", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601975", "species_10601970", "species_10602616" ], "products": [ "species_10602618" ], "modifiers": [], "additional_components": [ "WBGene00006648", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10602624": { "compartment": "compartment_7660", "id": "reaction_10602624", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602065", "species_10602620" ], "products": [ "species_10602622" ], "modifiers": [], "additional_components": [ "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604166": { "compartment": "compartment_7660", "id": "reaction_10604166", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10602053" ], "products": [ "species_10602616" ], "modifiers": [], "additional_components": [ "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10604170": { "compartment": "compartment_7660", "id": "reaction_10604170", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599973", "species_10602618" ], "products": [ "species_10602620" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604172": { "compartment": "compartment_7660", "id": "reaction_10604172", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602622", "species_10601853" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10630113": { "compartment": "compartment_876", "id": "reaction_10630113", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10630110", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10629838": { "compartment": "compartment_876", "id": "reaction_10629838", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629835", "catalyst" ] ], "additional_components": [ "Q21529", "WBGene00006658", "P90863", "WBGene00006682", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659" ] }, "reaction_10629479": { "compartment": "compartment_876", "id": "reaction_10629479", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629476", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629865": { "compartment": "compartment_876", "id": "reaction_10629865", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629862", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10629773": { "compartment": "compartment_876", "id": "reaction_10629773", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629770", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10629494": { "compartment": "compartment_876", "id": "reaction_10629494", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10629491", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629948": { "compartment": "compartment_876", "id": "reaction_10629948", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629945", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10660945": { "compartment": "compartment_70101", "id": "reaction_10660945", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941", "species_10615184" ], "products": [ "species_10660943" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660953": { "compartment": "compartment_70101", "id": "reaction_10660953", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941" ], "products": [ "species_10658641" ], "modifiers": [ [ "species_10615184", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "WBGene00005077" ] }, "reaction_10662401": { "compartment": "compartment_7660", "id": "reaction_10662401", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662397" ], "products": [ "species_10662399" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10658645": { "compartment": "compartment_7660", "id": "reaction_10658645", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658633", "species_10658641" ], "products": [ "species_10658643" ], "modifiers": [], "additional_components": [ "WBGene00000272", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662403": { "compartment": "compartment_70101", "id": "reaction_10662403", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662399" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660951": { "compartment": "compartment_70101", "id": "reaction_10660951", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10660943" ], "products": [ "species_29370", "species_10660948", "species_10615184" ], "modifiers": [ [ "species_10660943", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10615739": { "compartment": "compartment_876", "id": "reaction_10615739", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615735", "species_10615689" ], "products": [ "species_10615737" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10621789": { "compartment": "compartment_70101", "id": "reaction_10621789", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_113592", "species_10605399" ], "products": [ "species_29370", "species_10617723", "species_10621786" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "WBGene00003911" ] }, "reaction_10621774": { "compartment": "compartment_70101", "id": "reaction_10621774", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10618095": { "compartment": "compartment_70101", "id": "reaction_10618095", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612071", "species_113592", "species_10615689" ], "products": [ "species_10618093", "species_29370" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "Q5WRR1", "WBGene00006942", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10621778": { "compartment": "compartment_876", "id": "reaction_10621778", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10615689" ], "products": [ "species_10621776" ], "modifiers": [], "additional_components": [ "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P24348", "WBGene00002299" ] }, "reaction_10615733": { "compartment": "compartment_876", "id": "reaction_10615733", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615689" ], "products": [ "species_10615731" ], "modifiers": [], "additional_components": [ "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "C6KRM7", "WBGene00004372", "Q5WRR1", "WBGene00006942" ] }, "reaction_10614145": { "compartment": "compartment_70101", "id": "reaction_10614145", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614142", "species_29404" ], "products": [ "species_10614028" ], "modifiers": [ [ "species_10614142", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10614135": { "compartment": "compartment_984", "id": "reaction_10614135", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10614088" ], "products": [ "species_10614130", "species_10614132", "species_210382", "species_10614118", "species_10613945", "species_10614086", "species_10614100", "species_10614053" ], "modifiers": [ [ "species_10614088", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "species_74016", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10613856": { "compartment": "compartment_984", "id": "reaction_10613856", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_210382", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_29404", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ], [ "species_10613854", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624", "WBGene00017070" ] }, "reaction_10614091": { "compartment": "compartment_70101", "id": "reaction_10614091", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614028", "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048" ], "products": [ "species_10614088" ], "modifiers": [ [ "species_10614028", "catalyst" ], [ "species_10614068", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006752" ] }, "reaction_10636112": { "compartment": "compartment_5460", "id": "reaction_10636112", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10636120": { "compartment": "compartment_70616", "id": "reaction_10636120", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10636117", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10636123": { "compartment": "compartment_5460", "id": "reaction_10636123", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10614597": { "compartment": "compartment_70101", "id": "reaction_10614597", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_76194", "species_264643" ], "modifiers": [ [ "species_10614594", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10614589": { "compartment": "compartment_70101", "id": "reaction_10614589", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10614584" ], "products": [ "species_70106", "species_10614586" ], "modifiers": [ [ "species_10614568", "catalyst" ] ], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10615286": { "compartment": "compartment_70101", "id": "reaction_10615286", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614586", "species_10614053", "species_10614048" ], "products": [ "species_10615283" ], "modifiers": [ [ "species_10614586", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10615371": { "compartment": "compartment_876", "id": "reaction_10615371", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615283" ], "products": [ "species_10614130", "species_10614132", "species_10615368", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_372533" ], "modifiers": [ [ "species_10615283", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006756", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10645186": { "compartment": "compartment_261122", "id": "reaction_10645186", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645128" ], "products": [ "species_10645178" ], "modifiers": [ [ "species_10645184", "inhibitor" ] ], "additional_components": [ "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "Q21626", "WBGene00010974", "CHEBI:15996", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645954": { "compartment": "compartment_18730", "id": "reaction_10645954", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645950", "species_10645945" ], "products": [ "species_10645952" ], "modifiers": [], "additional_components": [ "WBGene00019536", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10645030": { "compartment": "compartment_13949", "id": "reaction_10645030", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645026", "species_10645008" ], "products": [ "species_10645028" ], "modifiers": [], "additional_components": [ "Q18286", "WBGene00016188", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "species_29438", "Q95ZS6", "WBGene00018869", "G5EFC1", "WBGene00004272", "O01803", "WBGene00004274", "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272" ] }, "reaction_10645054": { "compartment": "compartment_261122", "id": "reaction_10645054", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645028" ], "products": [ "species_10645052" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10645964": { "compartment": "compartment_18730", "id": "reaction_10645964", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645952" ], "modifiers": [ [ "species_10645950", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "WBGene00019536" ] }, "reaction_10645097": { "compartment": "compartment_70101", "id": "reaction_10645097", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644745", "species_10644720", "species_10644715", "species_10644735", "species_10644725", "species_10644710", "species_10644740", "species_10644730" ], "products": [ "species_10644747" ], "modifiers": [], "additional_components": [ "WBGene00019482", "WBGene00043992", "WBGene00000242", "WBGene00016744", "WBGene00010974", "WBGene00000241", "WBGene00000244", "WBGene00003892", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645130": { "compartment": "compartment_876", "id": "reaction_10645130", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10645126", "species_10645104" ], "products": [ "species_10645128" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q18510", "WBGene00000193", "species_29438", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086" ] }, "reaction_10645972": { "compartment": "compartment_18730", "id": "reaction_10645972", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645958" ], "products": [ "species_10645956", "species_10645950", "species_10645943" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "species_111349", "WBGene00019536", "WBGene00006843" ] }, "reaction_10645961": { "compartment": "compartment_18730", "id": "reaction_10645961", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645958" ], "modifiers": [ [ "species_10645952", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10644756": { "compartment": "compartment_2132649", "id": "reaction_10644756", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10644752" ], "products": [ "species_10644754" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "WBGene00010045", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q20759", "WBGene00010045", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10618833": { "compartment": "compartment_70101", "id": "reaction_10618833", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10618830", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "P91119", "WBGene00016328" ] }, "reaction_10631241": { "compartment": "compartment_70101", "id": "reaction_10631241", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612134", "species_1497857" ], "products": [ "species_29870", "species_10631239" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10630704": { "compartment": "compartment_70101", "id": "reaction_10630704", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630697", "species_10630689" ], "products": [ "species_10630699" ], "modifiers": [], "additional_components": [ "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10655778": { "compartment": "compartment_5460", "id": "reaction_10655778", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10655775", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10638217": { "compartment": "compartment_70101", "id": "reaction_10638217", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638215" ], "products": [ "species_111294", "species_76577", "species_10602923" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10610819": { "compartment": "compartment_70101", "id": "reaction_10610819", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10610816", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10638500": { "compartment": "compartment_70101", "id": "reaction_10638500", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638497", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10608120" ], "modifiers": [ [ "species_10638497", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10610781": { "compartment": "compartment_70101", "id": "reaction_10610781", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10611056": { "compartment": "compartment_876", "id": "reaction_10611056", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10611053", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207", "Q20734", "WBGene00043980" ] }, "reaction_10610836": { "compartment": "compartment_70101", "id": "reaction_10610836", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10630865": { "compartment": "compartment_70101", "id": "reaction_10630865", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630860", "species_113592" ], "products": [ "species_29370", "species_10630712" ], "modifiers": [ [ "species_10630862", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216667", "O02058", "WBGene00015010", "WBGene00015650" ] }, "reaction_10655786": { "compartment": "compartment_5460", "id": "reaction_10655786", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10655783", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10660041": { "compartment": "compartment_17927", "id": "reaction_10660041", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10660038", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10610809": { "compartment": "compartment_70101", "id": "reaction_10610809", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10610806", "catalyst" ] ], "additional_components": [ "P90755", "WBGene00007755" ] }, "reaction_10643425": { "compartment": "compartment_70101", "id": "reaction_10643425", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_71285", "species_549282" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10656369": { "compartment": "compartment_17951", "id": "reaction_10656369", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10656366", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10638520": { "compartment": "compartment_5460", "id": "reaction_10638520", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159297", "species_10599214" ], "products": [ "species_10599216" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10611068": { "compartment": "compartment_70101", "id": "reaction_10611068", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611065", "species_1497805" ], "products": [ "species_10611063", "species_198816" ], "modifiers": [ [ "species_10611065", "catalyst" ] ], "additional_components": [ "Q93315", "WBGene00007848", "species_71185", "Q93315", "WBGene00007848", "CHEBI:36144", "Q93315", "WBGene00007848", "species_71185" ] }, "reaction_10611568": { "compartment": "compartment_7660", "id": "reaction_10611568", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10611565", "catalyst" ] ], "additional_components": [ "species_216667", "P91851", "WBGene00009176" ] }, "reaction_10599221": { "compartment": "compartment_5460", "id": "reaction_10599221", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10599216", "catalyst" ] ], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10610789": { "compartment": "compartment_70101", "id": "reaction_10610789", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10638379": { "compartment": "compartment_70101", "id": "reaction_10638379", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3000241" ], "products": [ "species_29366", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10626242": { "compartment": "compartment_70101", "id": "reaction_10626242", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638503": { "compartment": "compartment_70101", "id": "reaction_10638503", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3149505" ], "products": [ "species_29366", "species_1130611", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10630701": { "compartment": "compartment_70101", "id": "reaction_10630701", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10630689", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_10630699", "inhibitor" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10638549": { "compartment": "compartment_70101", "id": "reaction_10638549", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10638546", "catalyst" ], [ "species_29386", "inhibitor" ], [ "species_73524", "inhibitor" ] ], "additional_components": [ "Q3LFN0", "WBGene00044637", "G4SDH4", "WBGene00021626" ] }, "reaction_10626228": { "compartment": "compartment_70101", "id": "reaction_10626228", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10611047": { "compartment": "compartment_70101", "id": "reaction_10611047", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "O45352", "WBGene00001792", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337" ] }, "reaction_10638491": { "compartment": "compartment_70101", "id": "reaction_10638491", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638483", "species_10638376" ], "products": [ "species_10638485" ], "modifiers": [], "additional_components": [ "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766" ] }, "reaction_10639602": { "compartment": "compartment_70101", "id": "reaction_10639602", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639600" ], "products": [ "species_10638369" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "species_266099", "O45430", "WBGene00009319" ] }, "reaction_10610846": { "compartment": "compartment_70101", "id": "reaction_10610846", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10610843", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10659491": { "compartment": "compartment_876", "id": "reaction_10659491", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10659488", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10611255": { "compartment": "compartment_876", "id": "reaction_10611255", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10611252", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10626163": { "compartment": "compartment_70101", "id": "reaction_10626163", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10626160", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10610799": { "compartment": "compartment_70101", "id": "reaction_10610799", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_29356" ], "products": [ "species_196931", "species_29372" ], "modifiers": [ [ "species_10610796", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10610771": { "compartment": "compartment_70101", "id": "reaction_10610771", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10610768", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_109496" ] }, "reaction_10662637": { "compartment": "compartment_5460", "id": "reaction_10662637", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113593" ], "products": [ "species_113563", "species_113581", "species_113529" ], "modifiers": [ [ "species_10662634", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10626240": { "compartment": "compartment_70101", "id": "reaction_10626240", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638489": { "compartment": "compartment_70101", "id": "reaction_10638489", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149479", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10626226": { "compartment": "compartment_70101", "id": "reaction_10626226", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10617657": { "compartment": "compartment_17951", "id": "reaction_10617657", "reactome": "R-CEL-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10617654", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10611561": { "compartment": "compartment_5460", "id": "reaction_10611561", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10611558", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10611139": { "compartment": "compartment_70101", "id": "reaction_10611139", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10611131" ], "products": [ "species_10602960", "species_158466" ], "modifiers": [ [ "species_10611136", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10630715": { "compartment": "compartment_70101", "id": "reaction_10630715", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10630712", "catalyst" ] ], "additional_components": [ "species_216667", "O02058", "WBGene00015010" ] }, "reaction_10638168": { "compartment": "compartment_70101", "id": "reaction_10638168", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638154" ], "products": [ "species_10638160", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10638207": { "compartment": "compartment_70101", "id": "reaction_10638207", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638200", "species_113592" ], "products": [ "species_10638205", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10626116": { "compartment": "compartment_70101", "id": "reaction_10626116", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10626113", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10638508": { "compartment": "compartment_70101", "id": "reaction_10638508", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149564", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10620516": { "compartment": "compartment_876", "id": "reaction_10620516", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_429739" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "species_8869604", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "species_197230", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "WBGene00014092" ] }, "reaction_10610761": { "compartment": "compartment_70101", "id": "reaction_10610761", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610758", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10638576": { "compartment": "compartment_70101", "id": "reaction_10638576", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10638573", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "O61198", "WBGene00017487", "O17892", "WBGene00010083", "Q960A1", "WBGene00015057", "CHEBI:44074", "species_113596" ] }, "reaction_10611119": { "compartment": "compartment_876", "id": "reaction_10611119", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_198836" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10611116", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "G8JZM6", "WBGene00021994", "O18057", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q9TYX7", "WBGene00021994", "Q18771", "WBGene00021994" ] }, "reaction_10641004": { "compartment": "compartment_70101", "id": "reaction_10641004", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10641002", "species_113592" ], "products": [ "species_111294", "species_10611528", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10626139": { "compartment": "compartment_70101", "id": "reaction_10626139", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10626123" ], "products": [ "species_10626128", "species_29432" ], "modifiers": [ [ "species_10626136", "catalyst" ] ], "additional_components": [ "species_216667", "O44510", "WBGene00018357", "species_216667", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10638578": { "compartment": "compartment_70101", "id": "reaction_10638578", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3149479", "species_10638495" ], "products": [ "species_10638497" ], "modifiers": [], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10626230": { "compartment": "compartment_70101", "id": "reaction_10626230", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10638518": { "compartment": "compartment_5460", "id": "reaction_10638518", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10638515", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10638506": { "compartment": "compartment_70101", "id": "reaction_10638506", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608124", "species_200665" ], "products": [ "species_10608120", "species_111355" ], "modifiers": [ [ "species_10608124", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260" ] }, "reaction_10626151": { "compartment": "compartment_70101", "id": "reaction_10626151", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10626148", "catalyst" ] ], "additional_components": [ "G5EGH2", "WBGene00003384", "species_109496" ] }, "reaction_10638382": { "compartment": "compartment_70101", "id": "reaction_10638382", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10638196": { "compartment": "compartment_70101", "id": "reaction_10638196", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638190", "species_113592" ], "products": [ "species_111294", "species_10638194", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10661102": { "compartment": "compartment_70101", "id": "reaction_10661102", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10644423": { "compartment": "compartment_70101", "id": "reaction_10644423", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644420", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "P90863", "WBGene00006682", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q21529", "WBGene00006658", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10660839": { "compartment": "compartment_7660", "id": "reaction_10660839", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660834", "species_77087" ], "products": [ "species_10660836", "species_77502" ], "modifiers": [ [ "species_10660834", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10661819": { "compartment": "compartment_7660", "id": "reaction_10661819", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10661812" ], "products": [ "species_10661816", "species_427486", "species_10661749" ], "modifiers": [ [ "species_10661812", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660958": { "compartment": "compartment_7660", "id": "reaction_10660958", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638691", "species_10658637" ], "products": [ "species_10660956" ], "modifiers": [], "additional_components": [ "Q09646", "WBGene00044072", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q09646", "WBGene00044072", "Q95ZL9", "WBGene00000272", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EFQ5", "WBGene00004393", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971" ] }, "reaction_10663484": { "compartment": "compartment_7660", "id": "reaction_10663484", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_29358" ], "products": [ "species_113582", "species_10663429" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10660771": { "compartment": "compartment_7660", "id": "reaction_10660771", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638603", "species_10658637" ], "products": [ "species_10660760" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661041": { "compartment": "compartment_7660", "id": "reaction_10661041", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661037", "species_10658637" ], "products": [ "species_10661039" ], "modifiers": [], "additional_components": [ "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660769": { "compartment": "compartment_7660", "id": "reaction_10660769", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660760", "species_77087" ], "products": [ "species_10660766", "species_77502" ], "modifiers": [ [ "species_10660760", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661097": { "compartment": "compartment_7660", "id": "reaction_10661097", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661087", "species_10597874" ], "products": [ "species_10661092", "species_10597899" ], "modifiers": [ [ "species_10661087", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "WBGene00004393", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10660861": { "compartment": "compartment_7660", "id": "reaction_10660861", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660856", "species_77087" ], "products": [ "species_10660858", "species_77502" ], "modifiers": [ [ "species_10660856", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10663499": { "compartment": "compartment_70101", "id": "reaction_10663499", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663486", "species_10627446" ], "products": [ "species_10663490" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660823": { "compartment": "compartment_7660", "id": "reaction_10660823", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660807", "species_77087" ], "products": [ "species_77502", "species_10660820" ], "modifiers": [ [ "species_10660807", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661089": { "compartment": "compartment_7660", "id": "reaction_10661089", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597899", "species_10660379" ], "products": [ "species_10661087" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00004393", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10661731": { "compartment": "compartment_7660", "id": "reaction_10661731", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658643", "species_10628901" ], "products": [ "species_10661729" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661099": { "compartment": "compartment_7660", "id": "reaction_10661099", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661092" ], "products": [ "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10664948": { "compartment": "compartment_7660", "id": "reaction_10664948", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611175", "species_10648260" ], "products": [ "species_10664946" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00006446", "O17850", "WBGene00006446", "O16850", "WBGene00000912" ] }, "reaction_10660832": { "compartment": "compartment_7660", "id": "reaction_10660832", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660827", "species_77087" ], "products": [ "species_10660829", "species_77502" ], "modifiers": [ [ "species_10660827", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10635481": { "compartment": "compartment_7660", "id": "reaction_10635481", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635477" ], "products": [ "species_10635479" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10663497": { "compartment": "compartment_70101", "id": "reaction_10663497", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10663490" ], "products": [ "species_10663492", "species_10627446" ], "modifiers": [ [ "species_10663490", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659819": { "compartment": "compartment_7660", "id": "reaction_10659819", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635483" ], "products": [ "species_10659817" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10635592": { "compartment": "compartment_7660", "id": "reaction_10635592", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635588", "species_10635496", "species_10635468" ], "products": [ "species_10635590" ], "modifiers": [], "additional_components": [ "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546", "WBGene00021636", "WBGene00008748", "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q9N3S7", "WBGene00021636", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q19404", "WBGene00008748", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546" ] }, "reaction_10660962": { "compartment": "compartment_7660", "id": "reaction_10660962", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10658637" ], "products": [ "species_10660960" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664997": { "compartment": "compartment_7660", "id": "reaction_10664997", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10611173" ], "products": [ "species_2485002", "species_10664992" ], "modifiers": [ [ "species_10664994", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366" ] }, "reaction_10664901": { "compartment": "compartment_70101", "id": "reaction_10664901", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664897", "species_10614198" ], "products": [ "species_10664899" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10660805": { "compartment": "compartment_7660", "id": "reaction_10660805", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660796", "species_77087" ], "products": [ "species_10660802", "species_77502" ], "modifiers": [ [ "species_10660796", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10660877": { "compartment": "compartment_7660", "id": "reaction_10660877", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660872", "species_77087" ], "products": [ "species_10660874", "species_77502" ], "modifiers": [ [ "species_10660872", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10635491": { "compartment": "compartment_7660", "id": "reaction_10635491", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635468", "species_10635477" ], "products": [ "species_10635489" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660884": { "compartment": "compartment_7660", "id": "reaction_10660884", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660879", "species_77087" ], "products": [ "species_10660881", "species_77502" ], "modifiers": [ [ "species_10660879", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10663445": { "compartment": "compartment_7660", "id": "reaction_10663445", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10663437" ], "products": [ "species_10660385", "species_113541" ], "modifiers": [ [ "species_10663442", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00021856" ] }, "reaction_10660389": { "compartment": "compartment_7660", "id": "reaction_10660389", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_10660383" ], "products": [ "species_10660387" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q95ZL9", "WBGene00000272", "P45896", "WBGene00004857", "G5EFQ5", "WBGene00004393", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10664907": { "compartment": "compartment_70101", "id": "reaction_10664907", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664903", "species_10664881" ], "products": [ "species_10664905" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10665000": { "compartment": "compartment_7660", "id": "reaction_10665000", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664992", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10611173" ], "modifiers": [ [ "species_10619855", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10664952": { "compartment": "compartment_7660", "id": "reaction_10664952", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10607873" ], "products": [ "species_10664950" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10660426": { "compartment": "compartment_7660", "id": "reaction_10660426", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10658637" ], "products": [ "species_113582", "species_10660419" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10661025": { "compartment": "compartment_7660", "id": "reaction_10661025", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661021", "species_10658637" ], "products": [ "species_10661023" ], "modifiers": [], "additional_components": [ "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664911": { "compartment": "compartment_70101", "id": "reaction_10664911", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664883", "species_10621567" ], "products": [ "species_10664909" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10659823": { "compartment": "compartment_7660", "id": "reaction_10659823", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635487", "species_10629366" ], "products": [ "species_10659821" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660224": { "compartment": "compartment_7660", "id": "reaction_10660224", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660220", "species_10658637" ], "products": [ "species_10660222" ], "modifiers": [], "additional_components": [ "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q86MF0", "WBGene00001439", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661755": { "compartment": "compartment_7660", "id": "reaction_10661755", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661739", "species_10661749" ], "products": [ "species_10661751" ], "modifiers": [ [ "species_10661753", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10662820": { "compartment": "compartment_7660", "id": "reaction_10662820", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10629366" ], "products": [ "species_113582", "species_10662817" ], "modifiers": [ [ "species_10648106", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10664885": { "compartment": "compartment_7660", "id": "reaction_10664885", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10660424": { "compartment": "compartment_7660", "id": "reaction_10660424", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660408", "species_29358" ], "products": [ "species_113582", "species_10660421" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10660428": { "compartment": "compartment_7660", "id": "reaction_10660428", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628901", "species_10658637" ], "products": [ "species_10660408" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659827": { "compartment": "compartment_7660", "id": "reaction_10659827", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635485", "species_10629366" ], "products": [ "species_10659825" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660868": { "compartment": "compartment_7660", "id": "reaction_10660868", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660863", "species_77087" ], "products": [ "species_10660865", "species_77502" ], "modifiers": [ [ "species_10660863", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661814": { "compartment": "compartment_7660", "id": "reaction_10661814", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661810", "species_10641328" ], "products": [ "species_10661812" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "WBGene00001837", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661742": { "compartment": "compartment_7660", "id": "reaction_10661742", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661729", "species_113560" ], "products": [ "species_2485002", "species_10661739" ], "modifiers": [ [ "species_10661729", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662813": { "compartment": "compartment_7660", "id": "reaction_10662813", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10658637" ], "products": [ "species_10662811" ], "modifiers": [ [ "species_10648106", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10657931": { "compartment": "compartment_7660", "id": "reaction_10657931", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657923", "species_10657927" ], "products": [ "species_10657929", "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00006380", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380", "Q10666", "WBGene00004077", "WBGene00001979" ] }, "reaction_10665048": { "compartment": "compartment_7660", "id": "reaction_10665048", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10628899" ], "products": [ "species_10665046" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000366", "P34545", "WBGene00000366", "O16850", "WBGene00000912" ] }, "reaction_10644162": { "compartment": "compartment_7660", "id": "reaction_10644162", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10643385", "species_10643390" ], "products": [ "species_10643405" ], "modifiers": [], "additional_components": [ "WBGene00003418", "WBGene00003422", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10644164": { "compartment": "compartment_7660", "id": "reaction_10644164", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643378", "species_10643373" ], "products": [ "species_10643380" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373" ] }, "reaction_10643409": { "compartment": "compartment_7660", "id": "reaction_10643409", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358514", "species_10643405" ], "products": [ "species_10643407" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643422": { "compartment": "compartment_7660", "id": "reaction_10643422", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10643407" ], "products": [ "species_113582", "species_10643394" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643398": { "compartment": "compartment_7660", "id": "reaction_10643398", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643380", "species_10598196", "species_10643394" ], "products": [ "species_10643396" ], "modifiers": [], "additional_components": [ "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "O02115", "WBGene00003955", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643420": { "compartment": "compartment_7660", "id": "reaction_10643420", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643416", "species_10643400" ], "products": [ "species_10643418" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O62245", "WBGene00009731", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643403": { "compartment": "compartment_7660", "id": "reaction_10643403", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643396" ], "products": [ "species_10643400" ], "modifiers": [ [ "species_10643396", "catalyst" ] ], "additional_components": [ "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10618428": { "compartment": "compartment_70101", "id": "reaction_10618428", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618374" ], "products": [ "species_29370", "species_10618425" ], "modifiers": [ [ "species_10618374", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111" ] }, "reaction_10618502": { "compartment": "compartment_70101", "id": "reaction_10618502", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618425", "species_113592" ], "products": [ "species_29370", "species_10618499" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10618464": { "compartment": "compartment_70101", "id": "reaction_10618464", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618238" ], "products": [ "species_29370", "species_10618461" ], "modifiers": [ [ "species_10613594", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q01630", "WBGene00006769", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q21773", "WBGene00000963", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "Q18677", "WBGene00000964", "Q22243", "WBGene00022780", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "O02064", "WBGene00022780" ] }, "reaction_10599289": { "compartment": "compartment_70101", "id": "reaction_10599289", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10599286", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10599309": { "compartment": "compartment_70101", "id": "reaction_10599309", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10599306", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10599299": { "compartment": "compartment_70101", "id": "reaction_10599299", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10599296", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10625266": { "compartment": "compartment_70101", "id": "reaction_10625266", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10639641": { "compartment": "compartment_70101", "id": "reaction_10639641", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10639638", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10639334": { "compartment": "compartment_5460", "id": "reaction_10639334", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10639331", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10639365": { "compartment": "compartment_984", "id": "reaction_10639365", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10639362", "catalyst" ] ], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10649479": { "compartment": "compartment_5460", "id": "reaction_10649479", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_113573", "species_5696194" ], "modifiers": [ [ "species_10649476", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10639564": { "compartment": "compartment_5460", "id": "reaction_10639564", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10639549" ], "products": [ "species_10639552", "species_113521" ], "modifiers": [ [ "species_10639561", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10639577": { "compartment": "compartment_5460", "id": "reaction_10639577", "reactome": "R-CEL-3323013", "name": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_1655887" ], "products": [ "species_1655882", "species_113521" ], "modifiers": [ [ "species_10639574", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10639589": { "compartment": "compartment_5460", "id": "reaction_10639589", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_10639552", "species_113529" ], "products": [ "species_113563", "species_10639549" ], "modifiers": [ [ "species_10639586", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10639598": { "compartment": "compartment_5460", "id": "reaction_10639598", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10639595", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10640254": { "compartment": "compartment_17927", "id": "reaction_10640254", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10640251", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639375": { "compartment": "compartment_70101", "id": "reaction_10639375", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10639372", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639607": { "compartment": "compartment_70616", "id": "reaction_10639607", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10606530" ], "products": [ "species_10606528", "species_189461" ], "modifiers": [], "additional_components": [ "Q23240", "WBGene00013854", "CHEBI:38574", "P19974", "WBGene00017121", "CHEBI:38573", "Q23240", "WBGene00013854", "P19974", "WBGene00017121" ] }, "reaction_10603119": { "compartment": "compartment_17951", "id": "reaction_10603119", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10603116", "catalyst" ] ], "additional_components": [ "species_71185", "Q8MYL7", "WBGene00013220", "species_113601" ] }, "reaction_10641727": { "compartment": "compartment_17963", "id": "reaction_10641727", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641725" ], "products": [ "species_10639362" ], "modifiers": [], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901", "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10599744": { "compartment": "compartment_70101", "id": "reaction_10599744", "reactome": "R-CEL-71676", "name": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10599741", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10649557": { "compartment": "compartment_7660", "id": "reaction_10649557", "reactome": "R-CEL-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10649551" ], "products": [ "species_10649553" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10649555": { "compartment": "compartment_7660", "id": "reaction_10649555", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10649553" ], "products": [ "species_427497", "species_10648323" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10648696": { "compartment": "compartment_7660", "id": "reaction_10648696", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641259", "species_10641290", "species_10648255" ], "products": [ "species_10648694" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "WBGene00022296", "WBGene00013924", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10649835": { "compartment": "compartment_7660", "id": "reaction_10649835", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648742", "species_10597874" ], "products": [ "species_10649551" ], "modifiers": [ [ "species_10648742", "catalyst" ] ], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648744": { "compartment": "compartment_7660", "id": "reaction_10648744", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10648740", "species_10648694" ], "products": [ "species_10648738", "species_10648742" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q23457", "WBGene00004320", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10633715": { "compartment": "compartment_12045", "id": "reaction_10633715", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10633712", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "Q21754", "WBGene00004039", "species_74016", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256" ] }, "reaction_10633605": { "compartment": "compartment_70101", "id": "reaction_10633605", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633602", "catalyst" ] ], "additional_components": [ "Q21754", "WBGene00004039", "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10633496": { "compartment": "compartment_70101", "id": "reaction_10633496", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10633493", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q95Q62", "WBGene00002979", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10633721": { "compartment": "compartment_70101", "id": "reaction_10633721", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633745": { "compartment": "compartment_876", "id": "reaction_10633745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633742", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q21754", "WBGene00004039", "species_74016", "G5EFI8", "WBGene00004036" ] }, "reaction_10633663": { "compartment": "compartment_70101", "id": "reaction_10633663", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10633660", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "species_109496" ] }, "reaction_10633682": { "compartment": "compartment_876", "id": "reaction_10633682", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633677", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10615561": { "compartment": "compartment_70101", "id": "reaction_10615561", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10615546" ], "products": [ "species_29370", "species_10615558" ], "modifiers": [ [ "species_10615546", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299" ] }, "reaction_10615698": { "compartment": "compartment_70101", "id": "reaction_10615698", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615694", "species_10615689" ], "products": [ "species_10615696" ], "modifiers": [], "additional_components": [ "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q9XWK4", "WBGene00013202" ] }, "reaction_10615677": { "compartment": "compartment_70101", "id": "reaction_10615677", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615453", "species_10615673" ], "products": [ "species_10615675" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00021369", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10658154": { "compartment": "compartment_70101", "id": "reaction_10658154", "reactome": "R-CEL-8855237", "name": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658145" ], "products": [ "species_29370", "species_10658152" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "WBGene00005077" ] }, "reaction_10618622": { "compartment": "compartment_70101", "id": "reaction_10618622", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618613", "species_10618615" ], "products": [ "species_10618617" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10615963": { "compartment": "compartment_984", "id": "reaction_10615963", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615959" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "WBGene00004372", "P17139", "WBGene00001263", "C6KRM7", "WBGene00004372", "P17139", "WBGene00001263" ] }, "reaction_10618620": { "compartment": "compartment_70101", "id": "reaction_10618620", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10618617", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10663513": { "compartment": "compartment_984", "id": "reaction_10663513", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_2299699" ], "products": [ "species_10663511" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10618951": { "compartment": "compartment_70101", "id": "reaction_10618951", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615741", "species_10615184" ], "products": [ "species_10615743" ], "modifiers": [], "additional_components": [ "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00005077", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615457": { "compartment": "compartment_876", "id": "reaction_10615457", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615453" ], "products": [ "species_10615455" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618943": { "compartment": "compartment_70101", "id": "reaction_10618943", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618938", "species_10617638" ], "products": [ "species_10618940", "species_29420" ], "modifiers": [ [ "species_10618938", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615459": { "compartment": "compartment_984", "id": "reaction_10615459", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615451", "species_10615440" ], "products": [ "species_10615453" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10624235": { "compartment": "compartment_876", "id": "reaction_10624235", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231", "species_10624224" ], "products": [ "species_10624233" ], "modifiers": [], "additional_components": [ "Q26261", "WBGene00006745", "G5EF96", "unc-40", "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "unc-40", "O44565", "WBGene00002247" ] }, "reaction_10618294": { "compartment": "compartment_70101", "id": "reaction_10618294", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618273", "species_10618290" ], "products": [ "species_10618292", "species_10615191" ], "modifiers": [], "additional_components": [ "WBGene00001490", "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10618595": { "compartment": "compartment_70101", "id": "reaction_10618595", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618584" ], "products": [ "species_29372", "species_10618586" ], "modifiers": [ [ "species_10618592", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "G5EBK8", "WBGene00004310", "species_111349", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10616046": { "compartment": "compartment_70101", "id": "reaction_10616046", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616020", "species_10616042" ], "products": [ "species_10616044" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618605": { "compartment": "compartment_70101", "id": "reaction_10618605", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10618602", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10618949": { "compartment": "compartment_70101", "id": "reaction_10618949", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618936", "species_10615485" ], "products": [ "species_10618938" ], "modifiers": [], "additional_components": [ "WBGene00000419", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618564": { "compartment": "compartment_70101", "id": "reaction_10618564", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618560", "species_10605399" ], "products": [ "species_10618562" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "Q03206", "ced-10", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q03206", "ced-10", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "species_29438", "Q95XP4", "WBGene00003111" ] }, "reaction_10618025": { "compartment": "compartment_70101", "id": "reaction_10618025", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10618020", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10615659": { "compartment": "compartment_876", "id": "reaction_10615659", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615655" ], "products": [ "species_10615657" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "unc-40", "species_179856" ] }, "reaction_10616034": { "compartment": "compartment_876", "id": "reaction_10616034", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616030" ], "products": [ "species_10616032" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10615967": { "compartment": "compartment_984", "id": "reaction_10615967", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_114570" ], "products": [ "species_10615965" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_113592" ] }, "reaction_10618022": { "compartment": "compartment_70101", "id": "reaction_10618022", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10618014" ], "products": [ "species_10618020" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618016": { "compartment": "compartment_70101", "id": "reaction_10618016", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602400", "species_10618010" ], "products": [ "species_10618014" ], "modifiers": [], "additional_components": [ "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618955": { "compartment": "compartment_70101", "id": "reaction_10618955", "reactome": "R-CEL-418874", "name": "Recruitment and activation of N-WASP by Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618940", "species_10612328", "species_179856" ], "products": [ "species_10618953" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "WBGene00007840", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_179856", "O62422", "WBGene00012532" ] }, "reaction_10663935": { "compartment": "compartment_984", "id": "reaction_10663935", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_2299699" ], "products": [ "species_10663933" ], "modifiers": [], "additional_components": [ "species_2299699", "G5EF96", "unc-40" ] }, "reaction_10615746": { "compartment": "compartment_70101", "id": "reaction_10615746", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615743", "species_113592" ], "products": [ "species_29370", "species_10615483" ], "modifiers": [ [ "species_10615743", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615650": { "compartment": "compartment_70101", "id": "reaction_10615650", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615646", "species_179856" ], "products": [ "species_10615648" ], "modifiers": [], "additional_components": [ "WBGene00001333", "G5EBK3", "WBGene00001333", "species_179856" ] }, "reaction_10618996": { "compartment": "compartment_70101", "id": "reaction_10618996", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10618993" ], "products": [ "species_29370", "species_10618560" ], "modifiers": [ [ "species_10618993", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10618318": { "compartment": "compartment_70101", "id": "reaction_10618318", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618242", "species_113592" ], "products": [ "species_29370", "species_10618315" ], "modifiers": [ [ "species_10618242", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780" ] }, "reaction_10660741": { "compartment": "compartment_70101", "id": "reaction_10660741", "reactome": "R-CEL-8933328", "name": "LYPLA2 hydrolyses PALM-C3,4-GAP43", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660731", "species_29356" ], "products": [ "species_3632881", "species_10660733" ], "modifiers": [ [ "species_10660738", "catalyst" ] ], "additional_components": [ "WBGene00018214", "WBGene00018214", "WBGene00010564" ] }, "reaction_10622809": { "compartment": "compartment_70101", "id": "reaction_10622809", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622806" ], "products": [ "species_29370", "species_10609588" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618607": { "compartment": "compartment_70101", "id": "reaction_10618607", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618600", "species_10618592" ], "products": [ "species_10618602" ], "modifiers": [], "additional_components": [ "WBGene00010374", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10615487": { "compartment": "compartment_70101", "id": "reaction_10615487", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615471", "species_10615483" ], "products": [ "species_10615485" ], "modifiers": [], "additional_components": [ "WBGene00006410", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615671": { "compartment": "compartment_70101", "id": "reaction_10615671", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615667", "species_10615453" ], "products": [ "species_10615669" ], "modifiers": [], "additional_components": [ "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618283": { "compartment": "compartment_876", "id": "reaction_10618283", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618208", "species_10618277" ], "products": [ "species_10618273", "species_10618281" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "O17905", "WBGene00001490", "WBGene00001490", "G5EE56", "WBGene00005077", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615500": { "compartment": "compartment_876", "id": "reaction_10615500", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615494", "species_10615496" ], "products": [ "species_10615498" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10615662": { "compartment": "compartment_70101", "id": "reaction_10615662", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615648" ], "products": [ "species_29370", "species_10615655" ], "modifiers": [ [ "species_10612166", "catalyst" ] ], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "WBGene00006599" ] }, "reaction_10622784": { "compartment": "compartment_70101", "id": "reaction_10622784", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618244": { "compartment": "compartment_70101", "id": "reaction_10618244", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618240", "species_10617742" ], "products": [ "species_10618242", "species_10617744" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10612171": { "compartment": "compartment_876", "id": "reaction_10612171", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10612168" ], "modifiers": [ [ "species_10612152", "catalyst" ] ], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10603943": { "compartment": "compartment_5460", "id": "reaction_10603943", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77276" ], "products": [ "species_77269", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603937": { "compartment": "compartment_5460", "id": "reaction_10603937", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603940": { "compartment": "compartment_5460", "id": "reaction_10603940", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10606622": { "compartment": "compartment_70101", "id": "reaction_10606622", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606632": { "compartment": "compartment_70101", "id": "reaction_10606632", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29878", "species_29790" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606636": { "compartment": "compartment_70101", "id": "reaction_10606636", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10610356": { "compartment": "compartment_984", "id": "reaction_10610356", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10610351": { "compartment": "compartment_984", "id": "reaction_10610351", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_174602", "species_171149" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10662935": { "compartment": "compartment_984", "id": "reaction_10662935", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10662932", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10610354": { "compartment": "compartment_984", "id": "reaction_10610354", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_192438", "species_174602" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10646460": { "compartment": "compartment_70101", "id": "reaction_10646460", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661262" ], "modifiers": [ [ "species_10646457", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10646450": { "compartment": "compartment_70101", "id": "reaction_10646450", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_29366", "species_5660033" ], "modifiers": [ [ "species_10646447", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10646471": { "compartment": "compartment_70101", "id": "reaction_10646471", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661281" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10646468": { "compartment": "compartment_70101", "id": "reaction_10646468", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661281", "species_113592" ], "products": [ "species_29370", "species_29790" ], "modifiers": [ [ "species_10646465", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10637289": { "compartment": "compartment_984", "id": "reaction_10637289", "reactome": "R-CEL-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_351629" ], "products": [ "species_10637270" ], "modifiers": [ [ "species_10637286", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:15858", "Q20616", "WBGene00009897" ] }, "reaction_10630811": { "compartment": "compartment_984", "id": "reaction_10630811", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630807" ], "products": [ "species_10630809" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636388": { "compartment": "compartment_984", "id": "reaction_10636388", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630809" ], "products": [ "species_10636386" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636390": { "compartment": "compartment_984", "id": "reaction_10636390", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631426" ], "products": [ "species_10631430" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263" ] }, "reaction_10648222": { "compartment": "compartment_5460", "id": "reaction_10648222", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598736", "species_113526" ], "products": [ "species_10648212", "species_5688274" ], "modifiers": [ [ "species_10648219", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "species_216667", "Q20480", "WBGene00004801" ] }, "reaction_10601562": { "compartment": "compartment_70101", "id": "reaction_10601562", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "products": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10601250": { "compartment": "compartment_70101", "id": "reaction_10601250", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601239" ], "products": [ "species_29370", "species_29372", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10666329": { "compartment": "compartment_12045", "id": "reaction_10666329", "reactome": "R-CEL-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666306": { "compartment": "compartment_70101", "id": "reaction_10666306", "reactome": "R-CEL-9751201", "name": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_9748947" ], "products": [ "species_10635280", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10666331": { "compartment": "compartment_70101", "id": "reaction_10666331", "reactome": "R-CEL-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10666335": { "compartment": "compartment_70101", "id": "reaction_10666335", "reactome": "R-CEL-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10666327": { "compartment": "compartment_70101", "id": "reaction_10666327", "reactome": "R-CEL-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10666324", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q9U2G5", "WBGene00003413", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411" ] }, "reaction_10636049": { "compartment": "compartment_70101", "id": "reaction_10636049", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10636046", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666268": { "compartment": "compartment_984", "id": "reaction_10666268", "reactome": "R-CEL-9749583", "name": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749786" ], "products": [ "species_9749576" ], "modifiers": [ [ "species_10624115", "catalyst" ] ], "additional_components": [ "species_9749790", "species_9749785", "species_9749790", "species_9749785", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666317": { "compartment": "compartment_70101", "id": "reaction_10666317", "reactome": "R-CEL-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10608242", "catalyst" ] ], "additional_components": [ "P10299", "WBGene00001749" ] }, "reaction_10666295": { "compartment": "compartment_70101", "id": "reaction_10666295", "reactome": "R-CEL-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003411" ] }, "reaction_10666333": { "compartment": "compartment_876", "id": "reaction_10666333", "reactome": "R-CEL-9753634", "name": "GGT dimers hydrolyse APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753685", "species_29356" ], "products": [ "species_9753680", "species_29404" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10666285": { "compartment": "compartment_17957", "id": "reaction_10666285", "reactome": "R-CEL-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666314": { "compartment": "compartment_70101", "id": "reaction_10666314", "reactome": "R-CEL-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10666252": { "compartment": "compartment_70101", "id": "reaction_10666252", "reactome": "R-CEL-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10636101": { "compartment": "compartment_70101", "id": "reaction_10636101", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10636104": { "compartment": "compartment_70101", "id": "reaction_10636104", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10599778", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10606291": { "compartment": "compartment_70101", "id": "reaction_10606291", "reactome": "R-CEL-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10606288", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10666322": { "compartment": "compartment_70101", "id": "reaction_10666322", "reactome": "R-CEL-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10666319", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412" ] }, "reaction_10666236": { "compartment": "compartment_70101", "id": "reaction_10666236", "reactome": "R-CEL-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10601884", "catalyst" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682" ] }, "reaction_10666250": { "compartment": "compartment_70101", "id": "reaction_10666250", "reactome": "R-CEL-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666257": { "compartment": "compartment_70101", "id": "reaction_10666257", "reactome": "R-CEL-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666289": { "compartment": "compartment_17957", "id": "reaction_10666289", "reactome": "R-CEL-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666302": { "compartment": "compartment_70101", "id": "reaction_10666302", "reactome": "R-CEL-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "WBGene00009499" ] }, "reaction_10666240": { "compartment": "compartment_70101", "id": "reaction_10666240", "reactome": "R-CEL-9748951", "name": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_9748998" ], "products": [ "species_9748992", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10666281": { "compartment": "compartment_17957", "id": "reaction_10666281", "reactome": "R-CEL-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10648942", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666304": { "compartment": "compartment_70101", "id": "reaction_10666304", "reactome": "R-CEL-9751037", "name": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015", "species_74113" ], "products": [ "species_83910", "species_9748998" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "WBGene00017867" ] }, "reaction_10666292": { "compartment": "compartment_70101", "id": "reaction_10666292", "reactome": "R-CEL-9750546", "name": "ABCC4 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750587", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750548", "species_29372" ], "modifiers": [ [ "species_10630658", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "pubchem.compound:3037883", "CHEBI:80613", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003412" ] }, "reaction_10666287": { "compartment": "compartment_5460", "id": "reaction_10666287", "reactome": "R-CEL-9750001", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749985", "species_159549" ], "products": [ "species_29374", "species_9750005" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10666245": { "compartment": "compartment_70101", "id": "reaction_10666245", "reactome": "R-CEL-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10666242", "catalyst" ] ], "additional_components": [ "Q09580", "WBGene00010912" ] }, "reaction_10666247": { "compartment": "compartment_70101", "id": "reaction_10666247", "reactome": "R-CEL-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10666255": { "compartment": "compartment_70101", "id": "reaction_10666255", "reactome": "R-CEL-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10608198", "catalyst" ] ], "additional_components": [ "O45010", "WBGene00021127" ] }, "reaction_10666278": { "compartment": "compartment_984", "id": "reaction_10666278", "reactome": "R-CEL-9749609", "name": "BCHE hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9749598" ], "products": [ "species_1524044", "species_351626", "species_9749546" ], "modifiers": [ [ "species_10666275", "catalyst" ] ], "additional_components": [ "WBGene00000037" ] }, "reaction_10666273": { "compartment": "compartment_984", "id": "reaction_10666273", "reactome": "R-CEL-9749607", "name": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749598" ], "products": [ "species_9749785" ], "modifiers": [ [ "species_10666270", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10666311": { "compartment": "compartment_70101", "id": "reaction_10666311", "reactome": "R-CEL-9753277", "name": "SULT dimers sulfate APAP to APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_9677362" ], "products": [ "species_9753448", "species_158466" ], "modifiers": [ [ "species_10666308", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10666283": { "compartment": "compartment_17957", "id": "reaction_10666283", "reactome": "R-CEL-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666300": { "compartment": "compartment_70101", "id": "reaction_10666300", "reactome": "R-CEL-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10666297", "catalyst" ] ], "additional_components": [ "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10636044": { "compartment": "compartment_70101", "id": "reaction_10636044", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161194", "species_29356" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10666238": { "compartment": "compartment_70101", "id": "reaction_10666238", "reactome": "R-CEL-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10661697": { "compartment": "compartment_70101", "id": "reaction_10661697", "reactome": "R-CEL-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648618", "species_10661684" ], "products": [ "species_10661694", "species_111294", "species_76577" ], "modifiers": [ [ "species_10661684", "catalyst" ] ], "additional_components": [ "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341" ] }, "reaction_10601554": { "compartment": "compartment_70101", "id": "reaction_10601554", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601535", "species_10601180" ], "products": [ "species_10601180", "species_10601108", "species_10601533" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00019162", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438" ] }, "reaction_10626992": { "compartment": "compartment_20699", "id": "reaction_10626992", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10626989", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10661677": { "compartment": "compartment_70101", "id": "reaction_10661677", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648620" ], "products": [ "species_10648618", "species_10648609" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657880": { "compartment": "compartment_70101", "id": "reaction_10657880", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10657877", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10606457": { "compartment": "compartment_17957", "id": "reaction_10606457", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10606454", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10662783": { "compartment": "compartment_70101", "id": "reaction_10662783", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10662772" ], "products": [ "species_10628859", "species_10662776" ], "modifiers": [ [ "species_10662772", "catalyst" ], [ "species_10662781", "inhibitor" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601258": { "compartment": "compartment_70101", "id": "reaction_10601258", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601197" ], "products": [ "species_10601199" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10627051": { "compartment": "compartment_20699", "id": "reaction_10627051", "reactome": "R-CEL-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10627048", "catalyst" ] ], "additional_components": [ "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10659540": { "compartment": "compartment_70101", "id": "reaction_10659540", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655541", "species_1131164", "species_10659531" ], "products": [ "species_10659538" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10622073": { "compartment": "compartment_17957", "id": "reaction_10622073", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10622070", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10606473": { "compartment": "compartment_12045", "id": "reaction_10606473", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10606470", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10622158": { "compartment": "compartment_17957", "id": "reaction_10622158", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10662739": { "compartment": "compartment_70101", "id": "reaction_10662739", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662726" ], "products": [ "species_10648618", "species_10662736" ], "modifiers": [ [ "species_10658432", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q93725", "WBGene00003587", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "A0A0K3AQR5", "T28F2.2b", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00003587", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A0A0K3AQR5", "T28F2.2b", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622134": { "compartment": "compartment_12045", "id": "reaction_10622134", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449222", "species_162756" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10622131", "catalyst" ] ], "additional_components": [ "U4PE03", "WBGene00019725", "P92012", "WBGene00011193" ] }, "reaction_10665016": { "compartment": "compartment_12045", "id": "reaction_10665016", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665014" ], "products": [ "species_10647827" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10622160": { "compartment": "compartment_17957", "id": "reaction_10622160", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10657617": { "compartment": "compartment_70101", "id": "reaction_10657617", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10657614", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P90859", "WBGene00009164", "Q9TW67", "WBGene00010160", "O16368", "WBGene00004502", "P54812", "WBGene00008053", "Q23451", "WBGene00013924", "Q9TXH9", "WBGene00017733", "Q93561", "WBGene00000843" ] }, "reaction_10659527": { "compartment": "compartment_70101", "id": "reaction_10659527", "reactome": "R-CEL-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659521" ], "products": [ "species_10659525" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00004184", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10622089": { "compartment": "compartment_17957", "id": "reaction_10622089", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10622086", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10647344": { "compartment": "compartment_70101", "id": "reaction_10647344", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10601707" ], "products": [ "species_174390", "species_10601705" ], "modifiers": [ [ "species_10647341", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "P34436", "WBGene00018419" ] }, "reaction_10622168": { "compartment": "compartment_12045", "id": "reaction_10622168", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10622165", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10647352": { "compartment": "compartment_70101", "id": "reaction_10647352", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10647349", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10654760": { "compartment": "compartment_70101", "id": "reaction_10654760", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654738", "species_71284" ], "products": [ "species_10654745", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10647679": { "compartment": "compartment_7660", "id": "reaction_10647679", "reactome": "R-CEL-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647675", "species_10647670" ], "products": [ "species_10647677" ], "modifiers": [], "additional_components": [ "WBGene00015217", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q17525", "WBGene00015217" ] }, "reaction_10626198": { "compartment": "compartment_20699", "id": "reaction_10626198", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10626195", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10648804": { "compartment": "compartment_70101", "id": "reaction_10648804", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10648801", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10606465": { "compartment": "compartment_12045", "id": "reaction_10606465", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10606462", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10601558": { "compartment": "compartment_70101", "id": "reaction_10601558", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601175", "species_10601180", "species_10601108" ], "products": [ "species_10601556" ], "modifiers": [], "additional_components": [ "O61820", "WBGene00001228", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "P30642", "WBGene00001227", "Q94261", "WBGene00019543", "Q9XUP3", "WBGene00001233", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "Q18967", "WBGene00001229", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10601550": { "compartment": "compartment_70101", "id": "reaction_10601550", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601544" ], "products": [ "species_10601548", "species_10601546", "species_29372" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "species_29420", "G5EGT7", "WBGene00021857" ] }, "reaction_10606481": { "compartment": "compartment_70101", "id": "reaction_10606481", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10606478", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10614701": { "compartment": "compartment_876", "id": "reaction_10614701", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614687", "species_10614677", "species_10614697", "species_10614672", "species_10614692", "species_10614682", "species_10614667", "species_10614662" ], "products": [ "species_10614699" ], "modifiers": [], "additional_components": [ "WBGene00018703", "WBGene00016188", "WBGene00016606", "WBGene00016376", "WBGene00017284", "WBGene00013687", "WBGene00004752", "WBGene00004753", "Q18286", "WBGene00016188", "Q19262", "WBGene00017284", "Q18406", "WBGene00016376", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753" ] }, "reaction_10658789": { "compartment": "compartment_70101", "id": "reaction_10658789", "reactome": "R-CEL-8865774", "name": "TTLLs polyglutamylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29404" ], "products": [ "species_29370", "species_10658759", "species_29372" ], "modifiers": [ [ "species_10658786", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q564U4", "WBGene00044187", "H2KZM9", "WBGene00019230", "Q09512", "WBGene00008405", "Q09647", "WBGene00014232", "E9P886", "WBGene00008331" ] }, "reaction_10620021": { "compartment": "compartment_876", "id": "reaction_10620021", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620018", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10622109": { "compartment": "compartment_17957", "id": "reaction_10622109", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10622106", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10659795": { "compartment": "compartment_70101", "id": "reaction_10659795", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659631", "species_1131164" ], "products": [ "species_10659790", "species_111294", "species_10659792" ], "modifiers": [ [ "species_10659631", "catalyst" ] ], "additional_components": [ "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662768": { "compartment": "compartment_7660", "id": "reaction_10662768", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662761" ], "products": [ "species_10662763", "species_10662765" ], "modifiers": [ [ "species_10648738", "catalyst" ] ], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q93725", "WBGene00003587", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00003587", "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622081": { "compartment": "compartment_12045", "id": "reaction_10622081", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10622078", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10647620": { "compartment": "compartment_2133233", "id": "reaction_10647620", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10647617", "catalyst" ] ], "additional_components": [ "species_1602402", "species_194276", "species_1602402", "species_194276", "WBGene00000020" ] }, "reaction_10650582": { "compartment": "compartment_3828046", "id": "reaction_10650582", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647837" ], "products": [ "species_10647960" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10628543": { "compartment": "compartment_70101", "id": "reaction_10628543", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628539" ], "products": [ "species_10628541" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727" ] }, "reaction_10662774": { "compartment": "compartment_70101", "id": "reaction_10662774", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662770", "species_10628807" ], "products": [ "species_10662772" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "WBGene00001851", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601260": { "compartment": "compartment_70101", "id": "reaction_10601260", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601199", "species_72393" ], "products": [ "species_10601201" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10633480": { "compartment": "compartment_70101", "id": "reaction_10633480", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633474", "species_10633476" ], "products": [ "species_10633478" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91240", "WBGene00017245", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "O16927", "WBGene00017799", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O61749", "WBGene00018159", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P34642", "WBGene00013984", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "G5EE80", "WBGene00009012", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P91240", "WBGene00017245", "P90983", "WBGene00004498", "Q20822", "WBGene00010097", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10601560": { "compartment": "compartment_70101", "id": "reaction_10601560", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601556", "species_10601201" ], "products": [ "species_10601203" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "species_29438", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "Q95XR0", "WBGene00021466", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10622142": { "compartment": "compartment_12045", "id": "reaction_10622142", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10622139", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10601252": { "compartment": "compartment_70101", "id": "reaction_10601252", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601231", "species_10601226", "species_10601221" ], "products": [ "species_10601233" ], "modifiers": [], "additional_components": [ "WBGene00002066", "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10659633": { "compartment": "compartment_70101", "id": "reaction_10659633", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659538", "species_10659629" ], "products": [ "species_10659631" ], "modifiers": [], "additional_components": [ "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662660": { "compartment": "compartment_7660", "id": "reaction_10662660", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662451", "species_10662656" ], "products": [ "species_10662658" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00013606", "Q18963", "WBGene00008403", "G5ED41", "WBGene00013606", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320" ] }, "reaction_10606489": { "compartment": "compartment_12045", "id": "reaction_10606489", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10606486", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10661701": { "compartment": "compartment_70101", "id": "reaction_10661701", "reactome": "R-CEL-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661694", "species_113592", "species_10648618" ], "products": [ "species_10661699", "species_111294", "species_76577" ], "modifiers": [], "additional_components": [ "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587" ] }, "reaction_10622064": { "compartment": "compartment_17957", "id": "reaction_10622064", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10622056", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10647958": { "compartment": "compartment_3828046", "id": "reaction_10647958", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647827", "species_5685882" ], "products": [ "species_10647847", "species_10647837", "species_10647857" ], "modifiers": [ [ "species_10647955", "catalyst" ] ], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "Q9BL26", "WBGene00044760", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O01532", "WBGene00000218", "Q8MYN7", "WBGene00012681", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q22972", "WBGene00017881", "O01530", "WBGene00000219", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "U4PME4", "WBGene00044760" ] }, "reaction_10605938": { "compartment": "compartment_70101", "id": "reaction_10605938", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605934" ], "products": [ "species_10605936" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10662654": { "compartment": "compartment_70101", "id": "reaction_10662654", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662650", "species_10648772" ], "products": [ "species_10662652" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00013606", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "G5ED41", "WBGene00013606", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10601552": { "compartment": "compartment_70101", "id": "reaction_10601552", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601246", "species_10601542", "species_10601533" ], "products": [ "species_10601544" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "G5EGT7", "WBGene00021857", "species_29438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625280": { "compartment": "compartment_17957", "id": "reaction_10625280", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623945", "species_10625276" ], "products": [ "species_10625278" ], "modifiers": [], "additional_components": [ "WBGene00003964", "P34652", "WBGene00000567", "CHEBI:59080", "P27798", "WBGene00000802", "P34652", "WBGene00000567", "CHEBI:59080", "G5ED07", "WBGene00003964", "P27798", "WBGene00000802" ] }, "reaction_10659533": { "compartment": "compartment_70101", "id": "reaction_10659533", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659529" ], "products": [ "species_10659531" ], "modifiers": [ [ "species_10659525", "inhibitor" ] ], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10630959": { "compartment": "compartment_12045", "id": "reaction_10630959", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10661834": { "compartment": "compartment_984", "id": "reaction_10661834", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10661831", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10660478": { "compartment": "compartment_5460", "id": "reaction_10660478", "reactome": "R-CEL-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10660475", "catalyst" ] ], "additional_components": [ "WBGene00008801" ] }, "reaction_10631941": { "compartment": "compartment_984", "id": "reaction_10631941", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_109276" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631070": { "compartment": "compartment_12045", "id": "reaction_10631070", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10631067", "catalyst" ] ], "additional_components": [ "Q9U2G1", "WBGene00012897", "species_266099", "species_109496" ] }, "reaction_10631934": { "compartment": "compartment_984", "id": "reaction_10631934", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602375" ], "products": [ "species_1602366", "species_1602372" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631217": { "compartment": "compartment_20699", "id": "reaction_10631217", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631155" ], "products": [ "species_10631215" ], "modifiers": [], "additional_components": [ "Q965T2", "WBGene00021854", "species_194276", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631939": { "compartment": "compartment_984", "id": "reaction_10631939", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631075": { "compartment": "compartment_70101", "id": "reaction_10631075", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970", "species_1500578" ], "products": [ "species_76194", "species_75973" ], "modifiers": [ [ "species_10631072", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10630911": { "compartment": "compartment_17906", "id": "reaction_10630911", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10630908", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10630922": { "compartment": "compartment_12045", "id": "reaction_10630922", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10623952": { "compartment": "compartment_12045", "id": "reaction_10623952", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10603021", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q9N5S8", "WBGene00018657", "Q21812", "WBGene00011106" ] }, "reaction_10631123": { "compartment": "compartment_70616", "id": "reaction_10631123", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524067", "species_1524072" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10603078": { "compartment": "compartment_70101", "id": "reaction_10603078", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_75970" ], "products": [ "species_29360", "species_76114" ], "modifiers": [ [ "species_10603075", "catalyst" ] ], "additional_components": [ "P34517", "WBGene00010778", "Q9XTS4", "WBGene00009824" ] }, "reaction_10660215": { "compartment": "compartment_12045", "id": "reaction_10660215", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10660211" ], "products": [ "species_10660213" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10631235": { "compartment": "compartment_12045", "id": "reaction_10631235", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631219" ], "products": [ "species_10631153" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "species_426639", "Q965T2", "WBGene00021854" ] }, "reaction_10630997": { "compartment": "compartment_12045", "id": "reaction_10630997", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630967": { "compartment": "compartment_17906", "id": "reaction_10630967", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10630944": { "compartment": "compartment_12045", "id": "reaction_10630944", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631007": { "compartment": "compartment_12045", "id": "reaction_10631007", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10630887": { "compartment": "compartment_12045", "id": "reaction_10630887", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10630919": { "compartment": "compartment_12045", "id": "reaction_10630919", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10649397": { "compartment": "compartment_70101", "id": "reaction_10649397", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10649394", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10631146": { "compartment": "compartment_12045", "id": "reaction_10631146", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10631143", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10649433": { "compartment": "compartment_17906", "id": "reaction_10649433", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10649430", "catalyst" ] ], "additional_components": [ "species_114519", "species_6814795", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_109496" ] }, "reaction_10631014": { "compartment": "compartment_12045", "id": "reaction_10631014", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10659846": { "compartment": "compartment_70101", "id": "reaction_10659846", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659841", "species_113592" ], "products": [ "species_29370", "species_10659844" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10631167": { "compartment": "compartment_12045", "id": "reaction_10631167", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10631164", "catalyst" ] ], "additional_components": [ "P53439", "WBGene00016384", "species_109496" ] }, "reaction_10609637": { "compartment": "compartment_5460", "id": "reaction_10609637", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10609634", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10649368": { "compartment": "compartment_876", "id": "reaction_10649368", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10649365", "catalyst" ] ], "additional_components": [ "Q9U1Z6", "WBGene00013358", "Q18610", "WBGene00016644" ] }, "reaction_10631157": { "compartment": "compartment_20699", "id": "reaction_10631157", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631153", "species_429785" ], "products": [ "species_1524146", "species_10631155" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631041": { "compartment": "compartment_12045", "id": "reaction_10631041", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10631038", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631060": { "compartment": "compartment_20699", "id": "reaction_10631060", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10631057", "catalyst" ] ], "additional_components": [ "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631190": { "compartment": "compartment_12045", "id": "reaction_10631190", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10631187", "catalyst" ] ], "additional_components": [ "WBGene00012095" ] }, "reaction_10631120": { "compartment": "compartment_70101", "id": "reaction_10631120", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10631117", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631016": { "compartment": "compartment_12045", "id": "reaction_10631016", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630906": { "compartment": "compartment_12045", "id": "reaction_10630906", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631182": { "compartment": "compartment_12045", "id": "reaction_10631182", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10631177", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10631937": { "compartment": "compartment_984", "id": "reaction_10631937", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10603033": { "compartment": "compartment_12045", "id": "reaction_10603033", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10603030", "catalyst" ] ], "additional_components": [ "Q95R12", "WBGene00017888", "G5EE59", "WBGene00010902", "Q22267", "WBGene00011543", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q21812", "WBGene00011106" ] }, "reaction_10631932": { "compartment": "compartment_984", "id": "reaction_10631932", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426658", "species_109276" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10615365": { "compartment": "compartment_984", "id": "reaction_10615365", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10615360", "catalyst" ], [ "species_10615363", "inhibitor" ] ], "additional_components": [ "O01302", "WBGene00011362", "Q9U295", "WBGene00000037", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10659441": { "compartment": "compartment_70101", "id": "reaction_10659441", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10659438", "catalyst" ] ], "additional_components": [ "G5EEM9", "WBGene00019747", "G5EED9", "WBGene00010813" ] }, "reaction_10659911": { "compartment": "compartment_12045", "id": "reaction_10659911", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10659908", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "WBGene00010943" ] }, "reaction_10602878": { "compartment": "compartment_7660", "id": "reaction_10602878", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602869", "species_10602874" ], "products": [ "species_10602876" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10664492": { "compartment": "compartment_70101", "id": "reaction_10664492", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664474", "species_10617465" ], "products": [ "species_10664476" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664490": { "compartment": "compartment_17947", "id": "reaction_10664490", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664476", "species_10617443" ], "products": [ "species_10664478" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "WBGene00004193", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664488": { "compartment": "compartment_17947", "id": "reaction_10664488", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664478" ], "products": [ "species_10664486", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004193", "WBGene00004201" ] }, "reaction_10657346": { "compartment": "compartment_70101", "id": "reaction_10657346", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657343", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657341": { "compartment": "compartment_70101", "id": "reaction_10657341", "reactome": "R-CEL-8848338", "name": "PNPLA4 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10643167": { "compartment": "compartment_70101", "id": "reaction_10643167", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643163", "species_8876730" ], "products": [ "species_10643165" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_8876730", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10657349": { "compartment": "compartment_70101", "id": "reaction_10657349", "reactome": "R-CEL-8848355", "name": "PNPLA4 hydrolyzes retinyl palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2534407", "species_29356" ], "products": [ "species_8848337", "species_30209" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10664778": { "compartment": "compartment_70101", "id": "reaction_10664778", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664735", "species_10664774" ], "products": [ "species_10664776" ], "modifiers": [], "additional_components": [ "Q21746", "WBGene00019893", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10664366": { "compartment": "compartment_17947", "id": "reaction_10664366", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664361" ], "products": [ "species_10628859", "species_10664363" ], "modifiers": [ [ "species_10664361", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10664355": { "compartment": "compartment_17947", "id": "reaction_10664355", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664321", "species_10664319" ], "products": [ "species_10664323" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034" ] }, "reaction_10664353": { "compartment": "compartment_17947", "id": "reaction_10664353", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664323" ], "products": [ "species_10664351", "species_10662601" ], "modifiers": [], "additional_components": [ "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198" ] }, "reaction_10664944": { "compartment": "compartment_70101", "id": "reaction_10664944", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664940", "species_10664735" ], "products": [ "species_10664942" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10625255": { "compartment": "compartment_70101", "id": "reaction_10625255", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10625216", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10625195": { "compartment": "compartment_70101", "id": "reaction_10625195", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625192", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10625801": { "compartment": "compartment_917758", "id": "reaction_10625801", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614063", "species_10613945", "species_10614053", "species_10625246", "species_10614048" ], "products": [ "species_10625248" ], "modifiers": [ [ "species_10625246", "catalyst" ] ], "additional_components": [ "WBGene00006798", "WBGene00006750", "WBGene00006757", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10625207": { "compartment": "compartment_917757", "id": "reaction_10625207", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625204", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10607988": { "compartment": "compartment_70101", "id": "reaction_10607988", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607978", "species_29356" ], "products": [ "species_111294", "species_10607968" ], "modifiers": [ [ "species_10607985", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "P81299", "WBGene00000383" ] }, "reaction_10650541": { "compartment": "compartment_984", "id": "reaction_10650541", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10650538", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10657183": { "compartment": "compartment_876", "id": "reaction_10657183", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657179", "species_10657165" ], "products": [ "species_10657181" ], "modifiers": [], "additional_components": [ "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "WBGene00006875", "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "G5ED30", "WBGene00006875", "Q10953", "WBGene00006943" ] }, "reaction_10664096": { "compartment": "compartment_70101", "id": "reaction_10664096", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664158": { "compartment": "compartment_70101", "id": "reaction_10664158", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664108": { "compartment": "compartment_70101", "id": "reaction_10664108", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_111745", "species_9024815" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664098": { "compartment": "compartment_70101", "id": "reaction_10664098", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664102": { "compartment": "compartment_70101", "id": "reaction_10664102", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664104": { "compartment": "compartment_70101", "id": "reaction_10664104", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664100": { "compartment": "compartment_70101", "id": "reaction_10664100", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664106": { "compartment": "compartment_70101", "id": "reaction_10664106", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_9024463", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10648108": { "compartment": "compartment_7660", "id": "reaction_10648108", "reactome": "R-CEL-5686578", "name": "Activated ATM phosphorylates ABL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648103" ], "products": [ "species_113582", "species_10648106" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00000018", "WBGene00000018", "WBGene00000227" ] }, "reaction_10648895": { "compartment": "compartment_7660", "id": "reaction_10648895", "reactome": "R-CEL-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648884" ], "products": [ "species_113582", "species_10647722" ], "modifiers": [ [ "species_10648884", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648892": { "compartment": "compartment_7660", "id": "reaction_10648892", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648889" ], "products": [ "species_113582", "species_10647734" ], "modifiers": [ [ "species_10648889", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647750": { "compartment": "compartment_7660", "id": "reaction_10647750", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10647734" ], "products": [ "species_113550", "species_10647747" ], "modifiers": [ [ "species_10647707", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00001377" ] }, "reaction_10647638": { "compartment": "compartment_7660", "id": "reaction_10647638", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647634" ], "products": [ "species_10647636" ], "modifiers": [], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10647737": { "compartment": "compartment_7660", "id": "reaction_10647737", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647698" ], "products": [ "species_113582", "species_10647707" ], "modifiers": [ [ "species_10647734", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10648897": { "compartment": "compartment_7660", "id": "reaction_10648897", "reactome": "R-CEL-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10647693" ], "products": [ "species_10648889" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647759": { "compartment": "compartment_7660", "id": "reaction_10647759", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647755", "species_10607264", "species_10647734" ], "products": [ "species_10647757" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9BKZ9", "WBGene00001410", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q8WQG9", "WBGene00002178", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "P62784", "WBGene00001875" ] }, "reaction_10647653": { "compartment": "compartment_7660", "id": "reaction_10647653", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647636" ], "products": [ "species_113582", "species_10647650" ], "modifiers": [ [ "species_10647636", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10658362": { "compartment": "compartment_876", "id": "reaction_10658362", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658356", "species_10658351" ], "products": [ "species_10658360" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "P90761", "WBGene00006777" ] }, "reaction_10658873": { "compartment": "compartment_876", "id": "reaction_10658873", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10658793" ], "products": [ "species_10658869" ], "modifiers": [ [ "species_10658871", "inhibitor" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "P34574", "WBGene00011867", "O18014", "WBGene00011381", "Q9N489", "WBGene00022453", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P51485", "WBGene00000195", "Q9U7D5", "WBGene00001519", "Q9BIF4", "WBGene00001224", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "A0A0K3AS36", "Y116A8C.36d", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "species_179856", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10659086": { "compartment": "compartment_876", "id": "reaction_10659086", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659080", "species_10659078" ], "products": [ "species_10659084" ], "modifiers": [], "additional_components": [ "WBGene00006751", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q9XZI6", "WBGene00006751", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10658373": { "compartment": "compartment_876", "id": "reaction_10658373", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658364", "species_10658369" ], "products": [ "species_10658371" ], "modifiers": [], "additional_components": [ "WBGene00000894", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10658436": { "compartment": "compartment_70101", "id": "reaction_10658436", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658432", "species_10658414", "species_10658396" ], "products": [ "species_10658434" ], "modifiers": [], "additional_components": [ "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10658849": { "compartment": "compartment_876", "id": "reaction_10658849", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_10658843" ], "products": [ "species_10658845" ], "modifiers": [ [ "species_10658847", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P34711", "WBGene00006756", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658795": { "compartment": "compartment_876", "id": "reaction_10658795", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10658791" ], "products": [ "species_10658793" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519" ] }, "reaction_10658867": { "compartment": "compartment_876", "id": "reaction_10658867", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658821", "species_10658863" ], "products": [ "species_10658865" ], "modifiers": [], "additional_components": [ "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109" ] }, "reaction_10658441": { "compartment": "compartment_70101", "id": "reaction_10658441", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648614", "species_10658356" ], "products": [ "species_10658396" ], "modifiers": [], "additional_components": [ "WBGene00003587", "WBGene00006777", "WBGene00006777" ] }, "reaction_10658825": { "compartment": "compartment_70101", "id": "reaction_10658825", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658815", "species_10658821" ], "products": [ "species_10658823" ], "modifiers": [], "additional_components": [ "G5EFF7", "WBGene00008852", "P90879", "WBGene00009878", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10665766": { "compartment": "compartment_70101", "id": "reaction_10665766", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_9648300" ], "products": [ "species_10658847" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658439": { "compartment": "compartment_70101", "id": "reaction_10658439", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658434" ], "products": [ "species_10658432", "species_10658414", "species_10648614", "species_10658356" ], "modifiers": [ [ "species_10658434", "catalyst" ] ], "additional_components": [ "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00003587", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10601944": { "compartment": "compartment_70101", "id": "reaction_10601944", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_73566", "species_29356" ], "products": [ "species_29404", "species_111294", "species_111292" ], "modifiers": [ [ "species_10601941", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10665762": { "compartment": "compartment_70101", "id": "reaction_10665762", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10601884" ], "products": [ "species_10601887" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10601903": { "compartment": "compartment_70101", "id": "reaction_10601903", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601889": { "compartment": "compartment_70101", "id": "reaction_10601889", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10601884", "catalyst" ], [ "species_10601887", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10604753": { "compartment": "compartment_70101", "id": "reaction_10604753", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604749" ], "products": [ "species_10601941" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601877": { "compartment": "compartment_70101", "id": "reaction_10601877", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10601874", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10601946": { "compartment": "compartment_70101", "id": "reaction_10601946", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10601926": { "compartment": "compartment_70101", "id": "reaction_10601926", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_111370" ], "products": [ "species_70106", "species_111395" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10601590": { "compartment": "compartment_70101", "id": "reaction_10601590", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601923": { "compartment": "compartment_70101", "id": "reaction_10601923", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111395", "species_29448", "species_113592" ], "products": [ "species_70106", "species_29370", "species_29372", "species_111399" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601941" ], "products": [ "species_10604749" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601934": { "compartment": "compartment_70101", "id": "reaction_10601934", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10601931", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10601593": { "compartment": "compartment_70101", "id": "reaction_10601593", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601900": { "compartment": "compartment_70101", "id": "reaction_10601900", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601913": { "compartment": "compartment_70101", "id": "reaction_10601913", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10604785": { "compartment": "compartment_70101", "id": "reaction_10604785", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10604782", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_109496" ] }, "reaction_10601603": { "compartment": "compartment_70101", "id": "reaction_10601603", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76633", "species_76632" ], "modifiers": [ [ "species_10601600", "catalyst" ] ], "additional_components": [ "species_73524", "O01815", "WBGene00020932" ] }, "reaction_10644465": { "compartment": "compartment_876", "id": "reaction_10644465", "reactome": "R-CEL-5602080", "name": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644461", "species_10605673" ], "products": [ "species_10644463" ], "modifiers": [], "additional_components": [ "species_977180", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "species_977180", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10658612": { "compartment": "compartment_70101", "id": "reaction_10658612", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29408", "species_29366" ], "modifiers": [ [ "species_10658609", "catalyst" ] ], "additional_components": [ "A0A061AD47", "WBGene00013289", "species_113596" ] }, "reaction_10628378": { "compartment": "compartment_5460", "id": "reaction_10628378", "reactome": "R-CEL-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10628375", "catalyst" ] ], "additional_components": [ "WBGene00014058" ] }, "reaction_10623673": { "compartment": "compartment_70101", "id": "reaction_10623673", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623615" ], "products": [ "species_10623671" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10613311": { "compartment": "compartment_984", "id": "reaction_10613311", "reactome": "R-CEL-204824", "name": "Interaction of Tie2 and Ang4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613307" ], "products": [ "species_10613309" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10618750": { "compartment": "compartment_70101", "id": "reaction_10618750", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10628230": { "compartment": "compartment_70101", "id": "reaction_10628230", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628228" ], "products": [ "species_10628138" ], "modifiers": [], "additional_components": [ "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230" ] }, "reaction_10618759": { "compartment": "compartment_70101", "id": "reaction_10618759", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618742", "species_10618746", "species_10610070" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10605677": { "compartment": "compartment_984", "id": "reaction_10605677", "reactome": "R-CEL-140791", "name": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605667", "species_10605556" ], "products": [ "species_10605675" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10614194": { "compartment": "compartment_70101", "id": "reaction_10614194", "reactome": "R-CEL-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10614189", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613017": { "compartment": "compartment_20699", "id": "reaction_10613017", "reactome": "R-CEL-204500", "name": "CyP60 chaperones Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613013", "species_10613008" ], "products": [ "species_10613015" ], "modifiers": [], "additional_components": [ "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "P52012", "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10613023": { "compartment": "compartment_20699", "id": "reaction_10613023", "reactome": "R-CEL-204549", "name": "Caveolin-1 binds Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613008", "species_10613019" ], "products": [ "species_10613021" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "WBGene00000301", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q94051", "WBGene00000301" ] }, "reaction_10605482": { "compartment": "compartment_70101", "id": "reaction_10605482", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10604943", "species_114519" ], "products": [ "species_10605480" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10620840": { "compartment": "compartment_70101", "id": "reaction_10620840", "reactome": "R-CEL-432143", "name": "PECAM-1 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10610622" ], "products": [ "species_10620838" ], "modifiers": [], "additional_components": [ "WBGene00006820", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "O01761", "WBGene00006820" ] }, "reaction_10618110": { "compartment": "compartment_876", "id": "reaction_10618110", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605490" ], "products": [ "species_10605439", "species_10605064", "species_10604843" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10623452": { "compartment": "compartment_876", "id": "reaction_10623452", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623438" ], "products": [ "species_10623450" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471" ] }, "reaction_10612267": { "compartment": "compartment_876", "id": "reaction_10612267", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612263", "species_10612257", "species_266099" ], "products": [ "species_10612265" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929" ] }, "reaction_10613785": { "compartment": "compartment_876", "id": "reaction_10613785", "reactome": "R-CEL-210285", "name": "Trans-homophilic interaction of PECAM-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613781" ], "products": [ "species_10613783" ], "modifiers": [], "additional_components": [ "WBGene00006820", "O01761", "WBGene00006820" ] }, "reaction_10618771": { "compartment": "compartment_70101", "id": "reaction_10618771", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618767" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613301": { "compartment": "compartment_876", "id": "reaction_10613301", "reactome": "R-CEL-204798", "name": "Interaction of Tie2 and p85 of PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602421" ], "products": [ "species_10613299" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613325": { "compartment": "compartment_876", "id": "reaction_10613325", "reactome": "R-CEL-204871", "name": "Interaction of Tie2 and Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602400" ], "products": [ "species_10613323" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004774", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10620439": { "compartment": "compartment_114584", "id": "reaction_10620439", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29372", "species_114565" ], "modifiers": [ [ "species_10620436", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10628226": { "compartment": "compartment_70101", "id": "reaction_10628226", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628152", "species_10628147" ], "products": [ "species_10628154" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10628373": { "compartment": "compartment_7660", "id": "reaction_10628373", "reactome": "R-CEL-1008200", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628369", "species_1008228" ], "products": [ "species_10628371" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521", "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521" ] }, "reaction_10628113": { "compartment": "compartment_70101", "id": "reaction_10628113", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628107", "species_10628102" ], "products": [ "species_10628111" ], "modifiers": [], "additional_components": [ "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215" ] }, "reaction_10625054": { "compartment": "compartment_70101", "id": "reaction_10625054", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625050", "species_10625045" ], "products": [ "species_10625052" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292" ] }, "reaction_10623288": { "compartment": "compartment_876", "id": "reaction_10623288", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623154" ], "products": [ "species_10623286" ], "modifiers": [], "additional_components": [ "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708", "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708" ] }, "reaction_10605543": { "compartment": "compartment_70101", "id": "reaction_10605543", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10605540", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10613779": { "compartment": "compartment_70101", "id": "reaction_10613779", "reactome": "R-CEL-210283", "name": "Interaction of PECAM-1 and PLC gamma1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10612156" ], "products": [ "species_10613777" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004038", "Q22070", "WBGene00004038", "O01761", "WBGene00006820" ] }, "reaction_10613000": { "compartment": "compartment_876", "id": "reaction_10613000", "reactome": "R-CEL-204434", "name": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10612996" ], "products": [ "species_10612998" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10621291": { "compartment": "compartment_70101", "id": "reaction_10621291", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10602421", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10666074": { "compartment": "compartment_984", "id": "reaction_10666074", "reactome": "R-CEL-9708859", "name": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666070" ], "products": [ "species_10666072", "species_10618735" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10618769": { "compartment": "compartment_70101", "id": "reaction_10618769", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10618763", "species_10610070" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613800": { "compartment": "compartment_70101", "id": "reaction_10613800", "reactome": "R-CEL-210291", "name": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613783" ], "products": [ "species_29370", "species_10613789" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "O01761", "WBGene00006820", "O01761", "WBGene00006820", "WBGene00005077" ] }, "reaction_10621374": { "compartment": "compartment_70101", "id": "reaction_10621374", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621366", "species_29438" ], "products": [ "species_10621368", "species_29420" ], "modifiers": [ [ "species_10621371", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q03206", "ced-10", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10623417": { "compartment": "compartment_876", "id": "reaction_10623417", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623365" ], "products": [ "species_10623415" ], "modifiers": [], "additional_components": [ "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "CHEBI:15996", "species_111349", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986", "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29420", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "species_29438", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986" ] }, "reaction_10628271": { "compartment": "compartment_70101", "id": "reaction_10628271", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628267", "species_10604862" ], "products": [ "species_10628269" ], "modifiers": [], "additional_components": [ "Q10955", "WBGene00004348", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "Q10955", "WBGene00004348", "P21137", "WBGene00002189", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052" ] }, "reaction_10605796": { "compartment": "compartment_984", "id": "reaction_10605796", "reactome": "R-CEL-141046", "name": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605792", "species_10605556" ], "products": [ "species_10605794" ], "modifiers": [], "additional_components": [ "WBGene00020921", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "G5EBU2", "WBGene00020921", "species_74016" ] }, "reaction_10605559": { "compartment": "compartment_984", "id": "reaction_10605559", "reactome": "R-CEL-114697", "name": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605545" ], "products": [ "species_10605439", "species_10605547" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10613027": { "compartment": "compartment_876", "id": "reaction_10613027", "reactome": "R-CEL-204600", "name": "Basigin homodimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925" ], "products": [ "species_10613025" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10659424": { "compartment": "compartment_12045", "id": "reaction_10659424", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869214", "species_29356" ], "products": [ "species_8869207", "species_29416" ], "modifiers": [ [ "species_10659421", "catalyst" ] ], "additional_components": [ "Q22943", "WBGene00003907", "G5EGT1", "WBGene00003906" ] }, "reaction_10665500": { "compartment": "compartment_17957", "id": "reaction_10665500", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665498" ], "products": [ "species_10623242" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618108": { "compartment": "compartment_876", "id": "reaction_10618108", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605439", "species_10605486" ], "products": [ "species_10605488" ], "modifiers": [], "additional_components": [ "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10605492": { "compartment": "compartment_70101", "id": "reaction_10605492", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605488" ], "products": [ "species_29420", "species_10605490" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10644326": { "compartment": "compartment_984", "id": "reaction_10644326", "reactome": "R-CEL-5578883", "name": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644322", "species_10605556" ], "products": [ "species_10644324" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10605697": { "compartment": "compartment_984", "id": "reaction_10605697", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605695", "species_9693058" ], "products": [ "species_10605667" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10628243": { "compartment": "compartment_17906", "id": "reaction_10628243", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628237" ], "products": [ "species_10628241" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10612983": { "compartment": "compartment_876", "id": "reaction_10612983", "reactome": "R-CEL-204392", "name": "Basigin binds MCT1, MCT3 and MCT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612973", "species_10612925" ], "products": [ "species_10612981" ], "modifiers": [], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10628232": { "compartment": "compartment_70101", "id": "reaction_10628232", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628170" ], "products": [ "species_10628178" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10638020": { "compartment": "compartment_876", "id": "reaction_10638020", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638016", "species_10638011" ], "products": [ "species_10638018" ], "modifiers": [], "additional_components": [ "WBGene00008800", "WBGene00009500", "Q19459", "WBGene00008800", "A0A1N7SYP5", "WBGene00009500" ] }, "reaction_10613297": { "compartment": "compartment_984", "id": "reaction_10613297", "reactome": "R-CEL-204779", "name": "Interaction of Tie2 with Ang1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613107" ], "products": [ "species_10613295" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10612243": { "compartment": "compartment_876", "id": "reaction_10612243", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612239", "species_10612233" ], "products": [ "species_10612241" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10620845": { "compartment": "compartment_70101", "id": "reaction_10620845", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10620842", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00005077" ] }, "reaction_10620455": { "compartment": "compartment_876", "id": "reaction_10620455", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620453" ], "products": [ "species_10605540" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10605787": { "compartment": "compartment_984", "id": "reaction_10605787", "reactome": "R-CEL-140872", "name": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605742" ], "products": [ "species_10605785", "species_9693058" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214" ] }, "reaction_10621362": { "compartment": "compartment_70101", "id": "reaction_10621362", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621354" ], "products": [ "species_10621356", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887" ] }, "reaction_10618757": { "compartment": "compartment_70101", "id": "reaction_10618757", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618754" ], "modifiers": [ [ "species_10618748", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10621249": { "compartment": "compartment_876", "id": "reaction_10621249", "reactome": "R-CEL-435244", "name": "PECAM1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613781" ], "products": [ "species_29370", "species_10613771" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00006820" ] }, "reaction_10605527": { "compartment": "compartment_70101", "id": "reaction_10605527", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605516" ], "products": [ "species_29370", "species_10605524" ], "modifiers": [ [ "species_10605480", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O44412", "WBGene00020298", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10664445": { "compartment": "compartment_984", "id": "reaction_10664445", "reactome": "R-CEL-9603302", "name": "Factor IIa inhibitors (peptide) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603327", "species_10605556" ], "products": [ "species_10664443" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6458", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6458", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470" ] }, "reaction_10605745": { "compartment": "compartment_876", "id": "reaction_10605745", "reactome": "R-CEL-140870", "name": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605675" ], "products": [ "species_10605742" ], "modifiers": [ [ "species_10605675", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618765": { "compartment": "compartment_70101", "id": "reaction_10618765", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10618735" ], "products": [ "species_10618763" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10613775": { "compartment": "compartment_70101", "id": "reaction_10613775", "reactome": "R-CEL-210277", "name": "Interaction of PECAM-1 and SHP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10613445" ], "products": [ "species_10613773" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004214", "G5EC24", "WBGene00004214", "O01761", "WBGene00006820" ] }, "reaction_10613321": { "compartment": "compartment_984", "id": "reaction_10613321", "reactome": "R-CEL-204863", "name": "Interaction of Tie2 with Ang2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613317" ], "products": [ "species_10613319" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628426": { "compartment": "compartment_70101", "id": "reaction_10628426", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628420", "species_10628422" ], "products": [ "species_10628424" ], "modifiers": [], "additional_components": [ "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "O62422", "WBGene00012532" ] }, "reaction_10618744": { "compartment": "compartment_70101", "id": "reaction_10618744", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10618735" ], "products": [ "species_10618742" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10628222": { "compartment": "compartment_70101", "id": "reaction_10628222", "reactome": "R-CEL-983266", "name": "Kinesins bind microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_10628216" ], "products": [ "species_10628218" ], "modifiers": [], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q9XU12", "WBGene00002219", "Q965T6", "WBGene00002230", "Q8MQ03", "WBGene00006974", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "P34540", "WBGene00006840", "P23678", "WBGene00006831", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "H9G2T2", "WBGene00002214", "G5EBX0", "WBGene00002228", "Q9XUS9", "WBGene00000875", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10663939": { "compartment": "compartment_984", "id": "reaction_10663939", "reactome": "R-CEL-9015379", "name": "Factor IIa inhibitors (compounds) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603311", "species_10605556" ], "products": [ "species_10663937" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "species_74016", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760" ] }, "reaction_10605466": { "compartment": "compartment_70101", "id": "reaction_10605466", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605453" ], "products": [ "species_10605463", "species_29420" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "WBGene00016570" ] }, "reaction_10615894": { "compartment": "compartment_876", "id": "reaction_10615894", "reactome": "R-CEL-375133", "name": "Basigin binds Mannose-carrying cell recognition molecules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615890" ], "products": [ "species_10615892" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q5WRR1", "WBGene00006942", "H2KZ60", "WBGene00016354" ] }, "reaction_10628291": { "compartment": "compartment_7660", "id": "reaction_10628291", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628287", "species_10628276" ], "products": [ "species_10628289" ], "modifiers": [], "additional_components": [ "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00000414", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34618", "WBGene00000414" ] }, "reaction_10618114": { "compartment": "compartment_876", "id": "reaction_10618114", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605463" ], "products": [ "species_10618112", "species_10605439", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10628300": { "compartment": "compartment_70101", "id": "reaction_10628300", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628296", "species_10625052" ], "products": [ "species_10628298" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "Q21301", "WBGene00010641" ] }, "reaction_10614187": { "compartment": "compartment_876", "id": "reaction_10614187", "reactome": "R-CEL-210881", "name": "Dimerization of Tie2/Ang1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613295" ], "products": [ "species_10614185" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10615042": { "compartment": "compartment_161320", "id": "reaction_10615042", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615034" ], "products": [ "species_10615040" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642" ] }, "reaction_10628341": { "compartment": "compartment_7660", "id": "reaction_10628341", "reactome": "R-CEL-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628337", "species_10628314" ], "products": [ "species_10628339" ], "modifiers": [], "additional_components": [ "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278" ] }, "reaction_10621346": { "compartment": "compartment_70101", "id": "reaction_10621346", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621334" ], "products": [ "species_10621336", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ], [ "species_10621344", "catalyst" ], [ "species_10621342", "inhibitor" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179856" ] }, "reaction_10628396": { "compartment": "compartment_74700", "id": "reaction_10628396", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628392", "species_10628383" ], "products": [ "species_10628394" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "W6SBE5", "WBGene00021538", "G5ECC3", "WBGene00004373" ] }, "reaction_10628220": { "compartment": "compartment_70101", "id": "reaction_10628220", "reactome": "R-CEL-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10628218" ], "products": [ "species_29370", "species_10628218" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10628224": { "compartment": "compartment_70101", "id": "reaction_10628224", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628143" ], "products": [ "species_10628145" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10623550": { "compartment": "compartment_876", "id": "reaction_10623550", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623520" ], "products": [ "species_10623548" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491", "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491" ] }, "reaction_10613808": { "compartment": "compartment_876", "id": "reaction_10613808", "reactome": "R-CEL-210304", "name": "Interaction of integrin alphaVbeta3 with PECAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10613781" ], "products": [ "species_10613806" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00006820", "Q27874", "WBGene00003930", "O01761", "WBGene00006820", "P34446", "WBGene00003929" ] }, "reaction_10614191": { "compartment": "compartment_70101", "id": "reaction_10614191", "reactome": "R-CEL-210974", "name": "Interaction of SOS-1 to Tie2 bound Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10613323" ], "products": [ "species_10614189" ], "modifiers": [], "additional_components": [ "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628941": { "compartment": "compartment_70101", "id": "reaction_10628941", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628847", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628811" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628943": { "compartment": "compartment_7660", "id": "reaction_10628943", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10628853" ], "products": [ "species_159942", "species_159939", "species_10628909" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628945": { "compartment": "compartment_70101", "id": "reaction_10628945", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628807", "species_10628835" ], "products": [ "species_10628863" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628939": { "compartment": "compartment_70101", "id": "reaction_10628939", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628931" ], "products": [ "species_10628818" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727" ] }, "reaction_10628921": { "compartment": "compartment_7660", "id": "reaction_10628921", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628907", "species_10628917" ], "products": [ "species_10628919" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628866": { "compartment": "compartment_70101", "id": "reaction_10628866", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10628863" ], "products": [ "species_10628859", "species_10628837" ], "modifiers": [ [ "species_10628863", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628887": { "compartment": "compartment_7660", "id": "reaction_10628887", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628855", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10628874" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628934": { "compartment": "compartment_7660", "id": "reaction_10628934", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628927", "species_10628919" ], "products": [ "species_10628931", "species_10628925" ], "modifiers": [ [ "species_10628919", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628843": { "compartment": "compartment_70101", "id": "reaction_10628843", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628839" ], "products": [ "species_10597908", "species_10628841" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "P0CG71", "WBGene00006727", "WBGene00006727", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628937": { "compartment": "compartment_70101", "id": "reaction_10628937", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628849", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628814" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10636006": { "compartment": "compartment_161320", "id": "reaction_10636006", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10636003", "catalyst" ] ], "additional_components": [ "O16454", "WBGene00007055", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "P52717", "WBGene00018271", "Q8MYN7", "WBGene00012681", "P43510", "WBGene00000786", "O17255", "WBGene00044760", "O01530", "WBGene00000219", "G5EEI4", "WBGene00000214", "Q9BL26", "WBGene00044760", "P52716", "WBGene00017969", "Q86NE0", "WBGene00000215", "P52715", "WBGene00008741", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O76725", "WBGene00021503", "O01532", "WBGene00000218", "P52714", "WBGene00007462", "Q2AAB9", "WBGene00044760", "Q22972", "WBGene00017881", "Q09991", "WBGene00019605", "G5EC01", "WBGene00077655", "U4PME4", "WBGene00044760" ] }, "reaction_10636398": { "compartment": "compartment_161320", "id": "reaction_10636398", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10636395", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10627920": { "compartment": "compartment_70101", "id": "reaction_10627920", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627918" ], "products": [ "species_983123", "species_10627781" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627946": { "compartment": "compartment_70101", "id": "reaction_10627946", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627851", "species_10627943" ], "products": [ "species_10627853", "species_10627941" ], "modifiers": [ [ "species_10627851", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344" ] }, "reaction_10618106": { "compartment": "compartment_70101", "id": "reaction_10618106", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615172" ], "products": [ "species_10618104" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10618097": { "compartment": "compartment_70101", "id": "reaction_10618097", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10628615": { "compartment": "compartment_876", "id": "reaction_10628615", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10628612", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10617865": { "compartment": "compartment_70101", "id": "reaction_10617865", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610909", "species_29356" ], "products": [ "species_10617862", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10627952": { "compartment": "compartment_70101", "id": "reaction_10627952", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627853", "species_10627859" ], "products": [ "species_10627851", "species_111294", "species_76577", "species_10627918" ], "modifiers": [ [ "species_10627859", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", 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"WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627954": { "compartment": "compartment_70101", "id": "reaction_10627954", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00001236", "Q20617", "WBGene00006719", "P34284", "WBGene00015350", "Q93349", "WBGene00007985", "Q9N3G1", "WBGene00021815", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "O62200", "WBGene00018654", "A0A2K5ATR7", "WBGene00022450", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q9U1Q1", "WBGene00006709", "P91404", "WBGene00019993", "O45495", "WBGene00006730", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q2WF61", "WBGene00044345", "Q9N5S5", "WBGene00018654", "Q17720", "WBGene00006717", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "A0A4V0IJV5", "WBGene00021406", "P91133", "WBGene00016326", "Q2AAC0", "WBGene00022168", "G5EG38", "WBGene00001281", "P34441", "WBGene00001284", "Q93903", "WBGene00001583", "Q17911", "WBGene00007529", "Q9U1U4", "WBGene00006714", "Q03607", "WBGene00018654", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q9N373", "WBGene00002278", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "Q17583", "WBGene00007252", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "Q18931", "WBGene00006703", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "A8DJA6", "WBGene00021721" ] }, "reaction_10628074": { "compartment": "compartment_70101", "id": "reaction_10628074", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10628071", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q09541", "WBGene00017686", "Q22531", "WBGene00022073" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_10618070" ], "products": [ "species_10618072" ], "modifiers": [ [ "species_10625485", "inhibitor" ] ], "additional_components": [ "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10627949": { "compartment": "compartment_70101", "id": "reaction_10627949", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627941", "species_29926", "species_10597908" ], "products": [ "species_10627943", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10627941", "catalyst" ] ], "additional_components": [ "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882" ] }, "reaction_10628590": { "compartment": "compartment_70101", "id": "reaction_10628590", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10605468", "species_114519" ], "products": [ "species_10605476" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10625498": { "compartment": "compartment_70101", "id": "reaction_10625498", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_113592" ], "products": [ "species_29370", "species_10625485" ], "modifiers": [ [ "species_10625495", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "P21137", "WBGene00002189", "H2KYN2", "WBGene00015650" ] }, "reaction_10612908": { "compartment": "compartment_12045", "id": "reaction_10612908", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612652", "species_10612904" ], "products": [ "species_10612906" ], "modifiers": [], "additional_components": [ "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "species_29438", "Q23445", "WBGene00022678" ] }, "reaction_10627862": { "compartment": "compartment_70101", "id": "reaction_10627862", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627855" ], "products": [ "species_10627851", "species_111294", "species_10627859", "species_76577" ], "modifiers": [ [ "species_10627781", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q9XUS3", "WBGene00003967", "Q95XX0", "WBGene00006708", "Q65XX2", "WBGene00021831", "Q21633", "WBGene00006713", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q09291", "WBGene00009738", "Q9TZ69", "WBGene00006715", "O45323", "WBGene00008439", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q9N2W9", "WBGene00006705", "Q17750", "WBGene00015555", 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"Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627910": { "compartment": "compartment_17957", "id": "reaction_10627910", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032", "species_113592", "species_29356" ], "products": [ "species_983034", "species_29370", "species_29372" ], "modifiers": [ [ "species_10627907", "catalyst" ] ], "additional_components": [ "O18227", "WBGene00001818", "Q9TZD9", "WBGene00001814", "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O44897", "WBGene00001819" ] }, "reaction_10627922": { "compartment": "compartment_70101", "id": "reaction_10627922", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_983036", "species_8942986", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628040": { "compartment": "compartment_17957", "id": "reaction_10628040", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10628037", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q22531", "WBGene00022073" ] }, "reaction_10618074": { "compartment": "compartment_70101", "id": "reaction_10618074", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615172" ], "products": [ "species_10615247", "species_111294" ], "modifiers": [ [ "species_10618061", "catalyst" ], [ "species_10618072", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_29420", "Q18246", "WBGene00004307", "H2L055", "WBGene00018734", "H2L2C2", "WBGene00012100", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920" ] }, "reaction_10633105": { "compartment": "compartment_876", "id": "reaction_10633105", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633263": { "compartment": "compartment_876", "id": "reaction_10633263", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633260", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "species_74016", "G5EDP9", "WBGene00000001", "species_266099", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10659805": { "compartment": "compartment_20699", "id": "reaction_10659805", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614984", "species_10659801", "species_1806217" ], "products": [ "species_10659803" ], "modifiers": [], "additional_components": [ "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806217", "Q9BKS2", "WBGene00022347", "G5EFK4", "WBGene00000183" ] }, "reaction_10656373": { "compartment": "compartment_70101", "id": "reaction_10656373", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656346", "species_10633219" ], "products": [ "species_10656371" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633324": { "compartment": "compartment_876", "id": "reaction_10633324", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633290": { "compartment": "compartment_876", "id": "reaction_10633290", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633287", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10656350": { "compartment": "compartment_70101", "id": "reaction_10656350", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656341", "species_10656346" ], "products": [ "species_10656348" ], "modifiers": [], "additional_components": [ "F53A2.8a", "WBGene00003479", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633206": { "compartment": "compartment_876", "id": "reaction_10633206", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10633203", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10656378": { "compartment": "compartment_876", "id": "reaction_10656378", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633035": { "compartment": "compartment_876", "id": "reaction_10633035", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633224": { "compartment": "compartment_876", "id": "reaction_10633224", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633132": { "compartment": "compartment_876", "id": "reaction_10633132", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10633316": { "compartment": "compartment_876", "id": "reaction_10633316", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10633313", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633243": { "compartment": "compartment_876", "id": "reaction_10633243", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633240", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10656381": { "compartment": "compartment_876", "id": "reaction_10656381", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633282": { "compartment": "compartment_876", "id": "reaction_10633282", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633311": { "compartment": "compartment_876", "id": "reaction_10633311", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633293": { "compartment": "compartment_876", "id": "reaction_10633293", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10633080": { "compartment": "compartment_876", "id": "reaction_10633080", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10633213": { "compartment": "compartment_876", "id": "reaction_10633213", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10605252": { "compartment": "compartment_7660", "id": "reaction_10605252", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605235" ], "products": [ "species_10601853", "species_10605250" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605237": { "compartment": "compartment_7660", "id": "reaction_10605237", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605233", "species_10605191", "species_10605151", "species_10605168", "species_10601853", "species_10605156", "species_10605228", "species_10605223" ], "products": [ "species_10605235" ], "modifiers": [], "additional_components": [ "WBGene00001259", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "Q9U3I0", "WBGene00009078", "Q9N554", "WBGene00021281", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00012000", "WBGene00008729", "P90783", "WBGene00008338", "G5EBY0", "WBGene00009103", "Q17431", "WBGene00007110", "A5Z2V7", "WBGene00008533", "Q9N5U5", "WBGene00018064", "Q03560", "WBGene00007184", "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10605248": { "compartment": "compartment_7660", "id": "reaction_10605248", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10605131", "species_10599967" ], "products": [ "species_10605241", "species_10601853" ], "modifiers": [ [ "species_10605131", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479" ] }, "reaction_10605284": { "compartment": "compartment_7660", "id": "reaction_10605284", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605250" ], "products": [ "species_9757634", "species_10605262" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605126", "species_10605241" ], "products": [ "species_10605243" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605266": { "compartment": "compartment_7660", "id": "reaction_10605266", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605262" ], "products": [ "species_10605264" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602928": { "compartment": "compartment_70101", "id": "reaction_10602928", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602925", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611542": { "compartment": "compartment_70101", "id": "reaction_10611542", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611530" ], "products": [ "species_29370", "species_10611537" ], "modifiers": [ [ "species_10611539", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10611550": { "compartment": "compartment_17927", "id": "reaction_10611550", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10611547", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10606867": { "compartment": "compartment_876", "id": "reaction_10606867", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10606864", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660206": { "compartment": "compartment_70101", "id": "reaction_10660206", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10611530", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611457": { "compartment": "compartment_70616", "id": "reaction_10611457", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10611454", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10645970": { "compartment": "compartment_13949", "id": "reaction_10645970", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645966", "species_10644752" ], "products": [ "species_10645968" ], "modifiers": [], "additional_components": [ "species_29438", "O01803", "WBGene00004274", "WBGene00010045", "Q20759", "WBGene00010045", "species_29438", "O01803", "WBGene00004274" ] }, "reaction_10640972": { "compartment": "compartment_876", "id": "reaction_10640972", "reactome": "R-CEL-4088218", "name": "Tetrastatin binds integrin alphaVbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10630428" ], "products": [ "species_10640970" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614491": { "compartment": "compartment_984", "id": "reaction_10614491", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614485", "species_10614487" ], "products": [ "species_10614489" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614512": { "compartment": "compartment_984", "id": "reaction_10614512", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614477", "species_10614508" ], "products": [ "species_10614510" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10640917": { "compartment": "compartment_876", "id": "reaction_10640917", "reactome": "R-CEL-4085083", "name": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640889", "species_10640891" ], "products": [ "species_10640915" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614720": { "compartment": "compartment_984", "id": "reaction_10614720", "reactome": "R-CEL-265426", "name": "Interaction of integrin alphaVbeta3 with Tenascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10614506" ], "products": [ "species_10614718" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614895": { "compartment": "compartment_984", "id": "reaction_10614895", "reactome": "R-CEL-349593", "name": "Interaction of integrin alphaIIbbeta3 with Fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10605504" ], "products": [ "species_10614893" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10623717": { "compartment": "compartment_5460", "id": "reaction_10623717", "reactome": "R-CEL-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113552", "species_113557" ], "modifiers": [ [ "species_10623712", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10598702": { "compartment": "compartment_70101", "id": "reaction_10598702", "reactome": "R-CEL-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10598697", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10619814": { "compartment": "compartment_70101", "id": "reaction_10619814", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10619801", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910" ] }, "reaction_10631293": { "compartment": "compartment_7660", "id": "reaction_10631293", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10611173", "species_10607873" ], "products": [ "species_10631291" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10622295": { "compartment": "compartment_876", "id": "reaction_10622295", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622293" ], "products": [ "species_10622291", "species_10622230" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "Q17446", "WBGene00004055", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10622324": { "compartment": "compartment_7660", "id": "reaction_10622324", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622320", "species_10622241" ], "products": [ "species_10622322" ], "modifiers": [], "additional_components": [ "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "Q9U325", "WBGene00003182", "Q9U325", "WBGene00003182", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948" ] }, "reaction_10615948": { "compartment": "compartment_876", "id": "reaction_10615948", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615942", "species_10615944" ], "products": [ "species_10615946" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10622246": { "compartment": "compartment_7660", "id": "reaction_10622246", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622214", "species_10622230" ], "products": [ "species_113582", "species_10622243" ], "modifiers": [ [ "species_10622230", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10666234": { "compartment": "compartment_17957", "id": "reaction_10666234", "reactome": "R-CEL-9737780", "name": "MTTP binds lomitapide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9737774", "species_10666230" ], "products": [ "species_10666232" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "CHEBI:16247", "species_171126", "G5ECG7", "WBGene00001099", "Q17770", "WBGene00003963", "CHEBI:16247", "species_9737774", "species_171126", "G5ECG7", "WBGene00001099" ] }, "reaction_10659889": { "compartment": "compartment_7660", "id": "reaction_10659889", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659881" ], "products": [ "species_10659887" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659903": { "compartment": "compartment_20699", "id": "reaction_10659903", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659901" ], "products": [ "species_10659897" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659885": { "compartment": "compartment_20699", "id": "reaction_10659885", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659879" ], "products": [ "species_10659881", "species_10659883" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10637200": { "compartment": "compartment_984", "id": "reaction_10637200", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10631810" ], "products": [ "species_10637198" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "WBGene00001403", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "O77469", "WBGene00001403" ] }, "reaction_10660724": { "compartment": "compartment_70101", "id": "reaction_10660724", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10660721", "catalyst" ] ], "additional_components": [ "O45719", "WBGene00021956", "Q95XV3", "WBGene00021956" ] }, "reaction_10663928": { "compartment": "compartment_70101", "id": "reaction_10663928", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10663931": { "compartment": "compartment_70101", "id": "reaction_10663931", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627109": { "compartment": "compartment_70101", "id": "reaction_10627109", "reactome": "R-CEL-977348", "name": "PHGDH tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728", "species_29360" ], "products": [ "species_70106", "species_73473", "species_977329" ], "modifiers": [ [ "species_10627106", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10664421": { "compartment": "compartment_70101", "id": "reaction_10664421", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627088": { "compartment": "compartment_70101", "id": "reaction_10627088", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10627085", "catalyst" ] ], "additional_components": [ "species_109496", "A0A061ACK7", "WBGene00013379" ] }, "reaction_10627099": { "compartment": "compartment_70101", "id": "reaction_10627099", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10627096", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10635804": { "compartment": "compartment_70101", "id": "reaction_10635804", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635794" ], "products": [ "species_10635802" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10644304": { "compartment": "compartment_7660", "id": "reaction_10644304", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10599971", "species_10644300" ], "products": [ "species_10644302" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9N585", "WBGene00004094", "O02092", "WBGene00018391", "O61931", "WBGene00019971", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q27484", "WBGene00001915", "O62275", "WBGene00010263", "Q9N5K2", "WBGene00019246", "P04255", "WBGene00001885", "Q09249", "WBGene00007624", "P09588", "WBGene00001877", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q27485", "WBGene00001909", "H2KZD5", "WBGene00017641", "Q27511", "WBGene00019947", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q10453", "WBGene00001945", "Q9XVI3", "WBGene00011945", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9U3I0", "WBGene00009078", "O16720", "WBGene00000106", "Q27894", "WBGene00001878", "Q17684", "WBGene00007355", "Q27490", "WBGene00001944", "G5ED77", "WBGene00011910", "K7ZUH9", "WBGene00001914", "A0A0U1RML5", "WBGene00018921", "Q19826", "WBGene00017830", "Q21770", "WBGene00011061", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q93338", "WBGene00007971", "Q27876", "WBGene00001922", "Q21691", "WBGene00019862", "G5EEH0", "WBGene00004323", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619797": { "compartment": "compartment_70101", "id": "reaction_10619797", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10612563" ], "products": [ "species_10619794" ], "modifiers": [ [ "species_10612563", "catalyst" ] ], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10635806": { "compartment": "compartment_70101", "id": "reaction_10635806", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619794" ], "products": [ "species_10635794" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10664156": { "compartment": "compartment_70101", "id": "reaction_10664156", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635780" ], "products": [ "species_10664153" ], "modifiers": [ [ "species_10635780", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910" ] }, "reaction_10632756": { "compartment": "compartment_70101", "id": "reaction_10632756", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632730": { "compartment": "compartment_70101", "id": "reaction_10632730", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10632727", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10644851": { "compartment": "compartment_70101", "id": "reaction_10644851", "reactome": "R-CEL-5618328", "name": "ATAT acetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_76183" ], "products": [ "species_76194", "species_10644843" ], "modifiers": [ [ "species_10644848", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00003178" ] }, "reaction_10644854": { "compartment": "compartment_70101", "id": "reaction_10644854", "reactome": "R-CEL-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10644843" ], "products": [ "species_10616991", "species_76183" ], "modifiers": [ [ "species_10643031", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00001838" ] }, "reaction_10633770": { "compartment": "compartment_7660", "id": "reaction_10633770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633646": { "compartment": "compartment_7660", "id": "reaction_10633646", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633666": { "compartment": "compartment_7660", "id": "reaction_10633666", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633767": { "compartment": "compartment_7660", "id": "reaction_10633767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633669": { "compartment": "compartment_7660", "id": "reaction_10633669", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633773": { "compartment": "compartment_7660", "id": "reaction_10633773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633591": { "compartment": "compartment_7660", "id": "reaction_10633591", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10633588", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10633761": { "compartment": "compartment_7660", "id": "reaction_10633761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633540": { "compartment": "compartment_7660", "id": "reaction_10633540", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633626": { "compartment": "compartment_7660", "id": "reaction_10633626", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10598876": { "compartment": "compartment_70101", "id": "reaction_10598876", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10598873", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10614940": { "compartment": "compartment_70101", "id": "reaction_10614940", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598873", "species_10614932" ], "products": [ "species_10614938" ], "modifiers": [], "additional_components": [ "WBGene00003844", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844" ] }, "reaction_10605806": { "compartment": "compartment_17951", "id": "reaction_10605806", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141349", "species_141343", "species_113535" ], "products": [ "species_141350", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10614952": { "compartment": "compartment_70101", "id": "reaction_10614952", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10614949", "catalyst" ] ], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615022": { "compartment": "compartment_70101", "id": "reaction_10615022", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10615019", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10615014": { "compartment": "compartment_70101", "id": "reaction_10615014", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10615011", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10615168": { "compartment": "compartment_70101", "id": "reaction_10615168", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614938" ], "products": [ "species_10614932" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "WBGene00022748", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10614964": { "compartment": "compartment_70101", "id": "reaction_10614964", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614958", "species_10614938" ], "products": [ "species_10614962" ], "modifiers": [], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615006": { "compartment": "compartment_70101", "id": "reaction_10615006", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10615004": { "compartment": "compartment_70101", "id": "reaction_10615004", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10605808": { "compartment": "compartment_17951", "id": "reaction_10605808", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_141323", "species_113535" ], "products": [ "species_141324", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10633102": { "compartment": "compartment_172574", "id": "reaction_10633102", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633226": { "compartment": "compartment_172574", "id": "reaction_10633226", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633246": { "compartment": "compartment_172574", "id": "reaction_10633246", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10665730": { "compartment": "compartment_7660", "id": "reaction_10665730", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608179", "species_10598178", "species_10598168", "species_10598173", "species_10598163" ], "products": [ "species_10608181" ], "modifiers": [], "additional_components": [ "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915", "WBGene00004338", "WBGene00004340", "WBGene00004339", "WBGene00018409", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q22664", "WBGene00011915" ] }, "reaction_10665732": { "compartment": "compartment_7660", "id": "reaction_10665732", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608167", "species_10608177", "species_10608172" ], "products": [ "species_10608179" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915" ] }, "reaction_10647775": { "compartment": "compartment_7660", "id": "reaction_10647775", "reactome": "R-CEL-5684081", "name": "MRN complex binds CDK2 and RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10597866", "species_10647771" ], "products": [ "species_10647773" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648902": { "compartment": "compartment_7660", "id": "reaction_10648902", "reactome": "R-CEL-5693608", "name": "Initial resection of double-strand break ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648899", "species_113518" ], "products": [ "species_30555", "species_10648080" ], "modifiers": [ [ "species_10648899", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647796": { "compartment": "compartment_7660", "id": "reaction_10647796", "reactome": "R-CEL-5684140", "name": "ATM phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647783" ], "products": [ "species_113582", "species_10647793" ], "modifiers": [ [ "species_10647783", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647786": { "compartment": "compartment_7660", "id": "reaction_10647786", "reactome": "R-CEL-5684096", "name": "CDK2 phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647773" ], "products": [ "species_113582", "species_10647783", "species_10597866" ], "modifiers": [ [ "species_10647773", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648089": { "compartment": "compartment_7660", "id": "reaction_10648089", "reactome": "R-CEL-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648082" ], "products": [ "species_30555", "species_10648086" ], "modifiers": [ [ "species_10648082", "catalyst" ] ], "additional_components": [ "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "O18017", "WBGene00001865", "Q23255", "WBGene00003405", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "Q9TYU5", "WBGene00007029", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648084": { "compartment": "compartment_7660", "id": "reaction_10648084", "reactome": "R-CEL-5685985", "name": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648026", "species_10648033", "species_10648080" ], "products": [ "species_10648082" ], "modifiers": [], "additional_components": [ "Q9U3F2", "WBGene00001016", "O18017", "WBGene00001865", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "WBGene00001049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648074": { "compartment": "compartment_7660", "id": "reaction_10648074", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10648066" ], "products": [ "species_427498", "species_427497", "species_10647771" ], "modifiers": [ [ "species_10648071", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10605272": { "compartment": "compartment_7660", "id": "reaction_10605272", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605124", "species_10603872" ], "products": [ "species_10605126" ], "modifiers": [], "additional_components": [ "WBGene00005014", "WBGene00005015", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014" ] }, "reaction_10605282": { "compartment": "compartment_7660", "id": "reaction_10605282", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605254" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605274": { "compartment": "compartment_7660", "id": "reaction_10605274", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605173", "species_10605178" ], "products": [ "species_10605180" ], "modifiers": [], "additional_components": [ "WBGene00001236", "WBGene00001235", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236" ] }, "reaction_10605280": { "compartment": "compartment_7660", "id": "reaction_10605280", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605245" ], "products": [ "species_10605245" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602932": { "compartment": "compartment_7660", "id": "reaction_10602932", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602930" ], "products": [ "species_10599973", "species_110068", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605286": { "compartment": "compartment_7660", "id": "reaction_10605286", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602944": { "compartment": "compartment_7660", "id": "reaction_10602944", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602934" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10605268": { "compartment": "compartment_7660", "id": "reaction_10605268", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605161", "species_10605166" ], "products": [ "species_10605168" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849" ] }, "reaction_10605288": { "compartment": "compartment_7660", "id": "reaction_10605288", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602069": { "compartment": "compartment_7660", "id": "reaction_10602069", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602067" ], "products": [ "species_10599973", "species_109877", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605276": { "compartment": "compartment_7660", "id": "reaction_10605276", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605180", "species_10605185" ], "products": [ "species_10605191" ], "modifiers": [], "additional_components": [ "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "WBGene00010990", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990" ] }, "reaction_10603082": { "compartment": "compartment_7660", "id": "reaction_10603082", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603080" ], "products": [ "species_10599973", "species_75897", "species_10601853", "species_10602065" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998" ] }, "reaction_10605270": { "compartment": "compartment_7660", "id": "reaction_10605270", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605107", "species_10605093" ], "products": [ "species_10605109" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "P34425", "WBGene00000507", "WBGene00000410", "O17869", "WBGene00009650", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410" ] }, "reaction_10605256": { "compartment": "compartment_7660", "id": "reaction_10605256", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605254" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605260": { "compartment": "compartment_7660", "id": "reaction_10605260", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605258" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10614605": { "compartment": "compartment_984", "id": "reaction_10614605", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10614602", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10613943": { "compartment": "compartment_984", "id": "reaction_10613943", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10613940", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "O01661", "WBGene00000368", "P34374", "WBGene00006772", "A0A3B1E663", "WBGene00006742", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10658294": { "compartment": "compartment_12045", "id": "reaction_10658294", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10658288" ], "products": [ "species_10658292" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10658322": { "compartment": "compartment_70101", "id": "reaction_10658322", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10648879" ], "products": [ "species_10658320" ], "modifiers": [], "additional_components": [ "species_163579", "CHEBI:16247", "species_171126", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_163579", "CHEBI:16247", "species_171126", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10634349": { "compartment": "compartment_12045", "id": "reaction_10634349", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10634342" ], "products": [ "species_159751", "species_10634346", "species_1650769" ], "modifiers": [ [ "species_10634340", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10634558": { "compartment": "compartment_984", "id": "reaction_10634558", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634519" ], "products": [ "species_10630807" ], "modifiers": [ [ "species_10634551", "catalyst" ], [ "species_10634556", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "O61901", "WBGene00020954", "Q20176", "WBGene00003555", "O61901", "WBGene00020954" ] }, "reaction_10634538": { "compartment": "compartment_984", "id": "reaction_10634538", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634443" ], "products": [ "species_10634519" ], "modifiers": [ [ "species_10634535", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q20176", "WBGene00003555", "Q19791", "WBGene00001650" ] }, "reaction_10634367": { "compartment": "compartment_17957", "id": "reaction_10634367", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10634360" ], "products": [ "species_10634364", "species_158602" ], "modifiers": [ [ "species_10634360", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10606608": { "compartment": "compartment_7660", "id": "reaction_10606608", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606604" ], "products": [ "species_10606606" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10606694": { "compartment": "compartment_70101", "id": "reaction_10606694", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606606" ], "products": [ "species_10606604" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10665614": { "compartment": "compartment_70101", "id": "reaction_10665614", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10614140": { "compartment": "compartment_984", "id": "reaction_10614140", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10614137", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10598798": { "compartment": "compartment_70101", "id": "reaction_10598798", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_31633" ], "products": [ "species_29370", "species_29472", "species_29372" ], "modifiers": [ [ "species_10598795", "catalyst" ] ], "additional_components": [ "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603", "Q9U307", "WBGene00001604", "Q95YD1", "WBGene00001602", "O02225", "WBGene00001607" ] }, "reaction_10636583": { "compartment": "compartment_70101", "id": "reaction_10636583", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731226", "species_29356" ], "products": [ "species_70106", "species_9731235", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636540": { "compartment": "compartment_70101", "id": "reaction_10636540", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10636537", "catalyst" ] ], "additional_components": [ "species_109496", "O61902", "WBGene00003579" ] }, "reaction_10636577": { "compartment": "compartment_70101", "id": "reaction_10636577", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9731304" ], "products": [ "species_70106", "species_9731298", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636580": { "compartment": "compartment_70101", "id": "reaction_10636580", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731300", "species_29356" ], "products": [ "species_70106", "species_9731296", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636550": { "compartment": "compartment_5460", "id": "reaction_10636550", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_159448", "species_2393950" ], "modifiers": [ [ "species_10636547", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_109496" ] }, "reaction_10625790": { "compartment": "compartment_70101", "id": "reaction_10625790", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625786", "species_10625769" ], "products": [ "species_10625788", "species_10625767" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542" ] }, "reaction_10625798": { "compartment": "compartment_876", "id": "reaction_10625798", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625796", "species_10625767" ], "products": [ "species_10625794", "species_10625769" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "species_179838", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542" ] }, "reaction_10625792": { "compartment": "compartment_70101", "id": "reaction_10625792", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625788", "species_10625721" ], "products": [ "species_10625727", "species_10625786" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "species_179838", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "P0CG71", "WBGene00006727", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193" ] }, "reaction_10617081": { "compartment": "compartment_984", "id": "reaction_10617081", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617006" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_380873", "species_10614053", "species_10615845" ], "modifiers": [ [ "species_10617006", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10643190": { "compartment": "compartment_70101", "id": "reaction_10643190", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617022", "species_10617017", "species_10617012" ], "products": [ "species_10617028" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615848": { "compartment": "compartment_984", "id": "reaction_10615848", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615843" ], "products": [ "species_10614130", "species_10614132", "species_10613945", "species_10614086", "species_10614116", "species_10614053", "species_374935", "species_10615845" ], "modifiers": [ [ "species_10615843", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10655657": { "compartment": "compartment_161320", "id": "reaction_10655657", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10655654", "catalyst" ] ], "additional_components": [ "CHEBI:71464", "CHEBI:85262", "CHEBI:71466", "CHEBI:85263", "CHEBI:85299", "species_5693752", "CHEBI:16196", "CHEBI:30805", "species_8934421", "species_422506", "species_390435", "CHEBI:28875", "Q9GUI1", "WBGene00021917" ] }, "reaction_10615853": { "compartment": "compartment_876", "id": "reaction_10615853", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048", "species_10615841" ], "products": [ "species_10615843" ], "modifiers": [ [ "species_10615841", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617030": { "compartment": "compartment_70101", "id": "reaction_10617030", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10616993", "species_10614053", "species_10614048" ], "products": [ "species_10617006" ], "modifiers": [ [ "species_10616993", "catalyst" ], [ "species_10617028", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615379": { "compartment": "compartment_374932", "id": "reaction_10615379", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10654711": { "compartment": "compartment_161320", "id": "reaction_10654711", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10654708", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10657921": { "compartment": "compartment_161320", "id": "reaction_10657921", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10657918", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10657916": { "compartment": "compartment_161320", "id": "reaction_10657916", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10657913", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10646383": { "compartment": "compartment_7660", "id": "reaction_10646383", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10646374" ], "products": [ "species_10646380", "species_113541" ], "modifiers": [ [ "species_10646374", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "species_266099", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10599229": { "compartment": "compartment_5460", "id": "reaction_10599229", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10599226", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10620180": { "compartment": "compartment_20699", "id": "reaction_10620180", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_29356" ], "products": [ "species_8934421", "species_428248" ], "modifiers": [ [ "species_10620177", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10636098": { "compartment": "compartment_70101", "id": "reaction_10636098", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142811" ], "products": [ "species_2142678", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10604164": { "compartment": "compartment_70101", "id": "reaction_10604164", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10604161", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_109496", "Q93934", "WBGene00011128" ] }, "reaction_10604092": { "compartment": "compartment_5460", "id": "reaction_10604092", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604812": { "compartment": "compartment_70101", "id": "reaction_10604812", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10617876": { "compartment": "compartment_17951", "id": "reaction_10617876", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10617873", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10651381": { "compartment": "compartment_5460", "id": "reaction_10651381", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797920", "species_6797917" ], "modifiers": [ [ "species_10651378", "catalyst" ] ], "additional_components": [ "species_113596", "A0A486WWC6", "WBGene00021355" ] }, "reaction_10665635": { "compartment": "compartment_70101", "id": "reaction_10665635", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10665629" ], "products": [ "species_10665631" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10601956": { "compartment": "compartment_5460", "id": "reaction_10601956", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10601953", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10601613": { "compartment": "compartment_70101", "id": "reaction_10601613", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10601610", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633842": { "compartment": "compartment_70101", "id": "reaction_10633842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861764", "species_29356" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10633839", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10599441": { "compartment": "compartment_70101", "id": "reaction_10599441", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_31311", "species_29356" ], "products": [ "species_70106", "species_73473", "species_31369" ], "modifiers": [ [ "species_10599438", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10602155": { "compartment": "compartment_70101", "id": "reaction_10602155", "reactome": "R-CEL-74215", "name": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_500260", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "species_113599", "species_83956", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10614847": { "compartment": "compartment_876", "id": "reaction_10614847", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266013", "species_109276" ], "products": [ "species_210382", "species_266074" ], "modifiers": [ [ "species_10614844", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10609829": { "compartment": "compartment_5460", "id": "reaction_10609829", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10609826", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10648965": { "compartment": "compartment_12045", "id": "reaction_10648965", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_29768", "species_1498751" ], "modifiers": [ [ "species_10648962", "catalyst" ] ], "additional_components": [ "WBGene00012750" ] }, "reaction_10613738": { "compartment": "compartment_70101", "id": "reaction_10613738", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_209794", "species_71285" ], "modifiers": [ [ "species_10613735", "catalyst" ] ], "additional_components": [ "P34254", "WBGene00015124", "Q20308", "WBGene00018340", "Q22279", "WBGene00011573" ] }, "reaction_10603959": { "compartment": "compartment_5460", "id": "reaction_10603959", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10623581": { "compartment": "compartment_70101", "id": "reaction_10623581", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482627", "species_113592" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10623578", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10602160": { "compartment": "compartment_70101", "id": "reaction_10602160", "reactome": "R-CEL-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10602157", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:57667", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10614546": { "compartment": "compartment_17960", "id": "reaction_10614546", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10614543", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_109496", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10638233": { "compartment": "compartment_5460", "id": "reaction_10638233", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10638230", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10603995": { "compartment": "compartment_5460", "id": "reaction_10603995", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77308" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10643274": { "compartment": "compartment_876", "id": "reaction_10643274", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10643271", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10630841": { "compartment": "compartment_70101", "id": "reaction_10630841", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10664496": { "compartment": "compartment_17963", "id": "reaction_10664496", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664676": { "compartment": "compartment_17963", "id": "reaction_10664676", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9604808" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10664673", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "O62115", "WBGene00011780", "H2L0F4", "WBGene00044618", "G5ECA6", "WBGene00011780", "O17750", "WBGene00011780", "Q9XU74", "WBGene00011780", "O02310", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62165", "WBGene00011780", "Q20575", "WBGene00009849", "O62375", "WBGene00011780", "G5EDB3", "WBGene00044630", "O62163", "WBGene00011780", "O02231", "WBGene00011780", "O62114", "WBGene00011780", "Q8MQG4", "WBGene00011780" ] }, "reaction_10660515": { "compartment": "compartment_17963", "id": "reaction_10660515", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10660512", "catalyst" ] ], "additional_components": [ "WBGene00000267" ] }, "reaction_10635654": { "compartment": "compartment_70101", "id": "reaction_10635654", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632925" ], "products": [ "species_10632931" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10606792": { "compartment": "compartment_5460", "id": "reaction_10606792", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10606780" ], "products": [ "species_10606782" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10658283": { "compartment": "compartment_12045", "id": "reaction_10658283", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10658280", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10633575": { "compartment": "compartment_70101", "id": "reaction_10633575", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10620259": { "compartment": "compartment_70101", "id": "reaction_10620259", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10635604": { "compartment": "compartment_12045", "id": "reaction_10635604", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10649513": { "compartment": "compartment_12045", "id": "reaction_10649513", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10649510", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10601689": { "compartment": "compartment_70101", "id": "reaction_10601689", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633672": { "compartment": "compartment_70101", "id": "reaction_10633672", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10602203": { "compartment": "compartment_70101", "id": "reaction_10602203", "reactome": "R-CEL-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10604102": { "compartment": "compartment_5460", "id": "reaction_10604102", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_109990", "species_113529" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10604099", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10602864": { "compartment": "compartment_70101", "id": "reaction_10602864", "reactome": "R-CEL-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10601577", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:58069", "CHEBI:58593", "species_727810", "species_109378", "species_109402", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10662674": { "compartment": "compartment_70101", "id": "reaction_10662674", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10662671", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10601633": { "compartment": "compartment_70101", "id": "reaction_10601633", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10599656": { "compartment": "compartment_70101", "id": "reaction_10599656", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599579", "species_113592" ], "products": [ "species_29370", "species_10599584" ], "modifiers": [ [ "species_10599653", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "P04630", "WBGene00000285", "P34335", "WBGene00015754", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "H2L0I6", "WBGene00022059", "O02159", "WBGene00020378", "Q9N3L4", "WBGene00021753", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10598455": { "compartment": "compartment_70101", "id": "reaction_10598455", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10598452", "catalyst" ] ], "additional_components": [ "Q564Q1", "WBGene00008132", "species_29360" ] }, "reaction_10649967": { "compartment": "compartment_5460", "id": "reaction_10649967", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10648292": { "compartment": "compartment_12045", "id": "reaction_10648292", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10648289", "catalyst" ] ], "additional_components": [ "WBGene00017515" ] }, "reaction_10620296": { "compartment": "compartment_70101", "id": "reaction_10620296", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10620293", "catalyst" ] ], "additional_components": [ "Q10022", "WBGene00020895", "Q19403", "WBGene00008749", "H2KZD1", "WBGene00018756" ] }, "reaction_10617789": { "compartment": "compartment_17951", "id": "reaction_10617789", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633115": { "compartment": "compartment_12045", "id": "reaction_10633115", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10633112", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10599096": { "compartment": "compartment_5460", "id": "reaction_10599096", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599093", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10633675": { "compartment": "compartment_70101", "id": "reaction_10633675", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10610954": { "compartment": "compartment_70101", "id": "reaction_10610954", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10610951", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10602188": { "compartment": "compartment_70101", "id": "reaction_10602188", "reactome": "R-CEL-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10663917": { "compartment": "compartment_70101", "id": "reaction_10663917", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10663914", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10637076": { "compartment": "compartment_70101", "id": "reaction_10637076", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10632691": { "compartment": "compartment_17957", "id": "reaction_10632691", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_1606280", "species_428256" ], "modifiers": [ [ "species_10632688", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_109496" ] }, "reaction_10650255": { "compartment": "compartment_70101", "id": "reaction_10650255", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10657188": { "compartment": "compartment_876", "id": "reaction_10657188", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10657185", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10636091": { "compartment": "compartment_12045", "id": "reaction_10636091", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10665955": { "compartment": "compartment_70101", "id": "reaction_10665955", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10665952", "catalyst" ] ], "additional_components": [ "O01927", "WBGene00007549", "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "Q18545", "WBGene00008033" ] }, "reaction_10649446": { "compartment": "compartment_876", "id": "reaction_10649446", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10649443", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649074": { "compartment": "compartment_5460", "id": "reaction_10649074", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10649053" ], "products": [ "species_5693984", "species_10649066", "species_5693978" ], "modifiers": [ [ "species_10649071", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10650376": { "compartment": "compartment_7660", "id": "reaction_10650376", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10650373", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00008458" ] }, "reaction_10599073": { "compartment": "compartment_70101", "id": "reaction_10599073", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10599070", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10604569": { "compartment": "compartment_70101", "id": "reaction_10604569", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10604566", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10665633": { "compartment": "compartment_70101", "id": "reaction_10665633", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665631" ], "products": [ "species_189386", "species_10665629" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10614855": { "compartment": "compartment_876", "id": "reaction_10614855", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10632904": { "compartment": "compartment_20699", "id": "reaction_10632904", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_744227" ], "products": [ "species_205687", "species_1660674" ], "modifiers": [ [ "species_10632901", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10658932": { "compartment": "compartment_7660", "id": "reaction_10658932", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10658929", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_216667", "Q09374", "WBGene00022673" ] }, "reaction_10648973": { "compartment": "compartment_13977", "id": "reaction_10648973", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693747", "species_5693752" ], "products": [ "species_5693733", "species_5693736" ], "modifiers": [ [ "species_10648970", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10598743": { "compartment": "compartment_70101", "id": "reaction_10598743", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_29406" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10625839": { "compartment": "compartment_876", "id": "reaction_10625839", "reactome": "R-CEL-917892", "name": "FLVCR1-1 transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71185" ], "products": [ "species_917877" ], "modifiers": [ [ "species_10625836", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10633276": { "compartment": "compartment_12045", "id": "reaction_10633276", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10633273", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10620499": { "compartment": "compartment_70101", "id": "reaction_10620499", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates CERT1-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620471", "species_113592" ], "products": [ "species_29370", "species_10620474" ], "modifiers": [ [ "species_10620496", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "O45818", "WBGene00012019", "Q9XUJ7", "WBGene00012352" ] }, "reaction_10625298": { "compartment": "compartment_5460", "id": "reaction_10625298", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_113557", "species_159549" ], "modifiers": [ [ "species_10625295", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10646515": { "compartment": "compartment_5668575", "id": "reaction_10646515", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10602200": { "compartment": "compartment_70101", "id": "reaction_10602200", "reactome": "R-CEL-74249", "name": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500245", "species_29372" ], "products": [ "species_500244", "species_83956" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "species_112016", "CHEBI:58576", "U4PSA1", "WBGene00019298" ] }, "reaction_10598754": { "compartment": "compartment_5460", "id": "reaction_10598754", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10656850": { "compartment": "compartment_70101", "id": "reaction_10656850", "reactome": "R-CEL-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10613758": { "compartment": "compartment_70101", "id": "reaction_10613758", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_159362", "species_113528" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10649405": { "compartment": "compartment_5460", "id": "reaction_10649405", "reactome": "R-CEL-5695980", "name": "ACAD10 dehydrogenates S-2MPDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695946", "species_113596" ], "products": [ "species_5695949", "species_31649" ], "modifiers": [ [ "species_10649402", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10648981": { "compartment": "compartment_12045", "id": "reaction_10648981", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10648978", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10603973": { "compartment": "compartment_5460", "id": "reaction_10603973", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10620208": { "compartment": "compartment_70101", "id": "reaction_10620208", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10637073": { "compartment": "compartment_70101", "id": "reaction_10637073", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10615384": { "compartment": "compartment_5460", "id": "reaction_10615384", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10615381", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10598437": { "compartment": "compartment_70101", "id": "reaction_10598437", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_109496" ] }, "reaction_10602986": { "compartment": "compartment_17951", "id": "reaction_10602986", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390404", "species_390426" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10601687": { "compartment": "compartment_70101", "id": "reaction_10601687", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10613721": { "compartment": "compartment_1462052", "id": "reaction_10613721", "reactome": "R-CEL-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351603", "species_351597", "species_351599" ], "modifiers": [ [ "species_10613718", "catalyst" ] ], "additional_components": [ "Q9XTQ6", "WBGene00006541", "CHEBI:18315", "CHEBI:28694" ] }, "reaction_10598445": { "compartment": "compartment_70101", "id": "reaction_10598445", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_30170" ], "products": [ "species_29548", "species_29452" ], "modifiers": [ [ "species_10598442", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10599677": { "compartment": "compartment_70101", "id": "reaction_10599677", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599664" ], "products": [ "species_10599669" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10632966": { "compartment": "compartment_20699", "id": "reaction_10632966", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632960" ], "products": [ "species_10632925" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10656397": { "compartment": "compartment_171062", "id": "reaction_10656397", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10656388", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10646163": { "compartment": "compartment_17963", "id": "reaction_10646163", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10646160", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00043980" ] }, "reaction_10613668": { "compartment": "compartment_984", "id": "reaction_10613668", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10598667": { "compartment": "compartment_5460", "id": "reaction_10598667", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113557", "species_113593" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10598664", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_199207", "species_266099" ] }, "reaction_10603955": { "compartment": "compartment_5460", "id": "reaction_10603955", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10648947": { "compartment": "compartment_17957", "id": "reaction_10648947", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10636081": { "compartment": "compartment_12045", "id": "reaction_10636081", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10636078", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "H2KYS3", "WBGene00000905", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620190": { "compartment": "compartment_70101", "id": "reaction_10620190", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428198", "species_428193" ], "modifiers": [ [ "species_10620187", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10598847": { "compartment": "compartment_5460", "id": "reaction_10598847", "reactome": "R-CEL-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10598844", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10631244": { "compartment": "compartment_70101", "id": "reaction_10631244", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10631239", "catalyst" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10601643": { "compartment": "compartment_70101", "id": "reaction_10601643", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633758": { "compartment": "compartment_70101", "id": "reaction_10633758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10662836": { "compartment": "compartment_70101", "id": "reaction_10662836", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10662833", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10633620": { "compartment": "compartment_70101", "id": "reaction_10633620", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10633617", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10603977": { "compartment": "compartment_5460", "id": "reaction_10603977", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10657668": { "compartment": "compartment_984", "id": "reaction_10657668", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936165", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851369" ], "modifiers": [ [ "species_10657665", "catalyst" ] ], "additional_components": [ "species_29420", "species_29370", "CHEBI:58069", "species_205687", "species_727810", "species_76577", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10599797": { "compartment": "compartment_70101", "id": "reaction_10599797", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10599794", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10623690": { "compartment": "compartment_5460", "id": "reaction_10623690", "reactome": "R-CEL-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10623685", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10617879": { "compartment": "compartment_17951", "id": "reaction_10617879", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390419", "species_390440" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10660679": { "compartment": "compartment_984", "id": "reaction_10660679", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10660676", "catalyst" ] ], "additional_components": [ "O01811", "WBGene00003170", "species_74016", "Q966L1", "WBGene00017089", "Q2V071", "WBGene00044697", "B1V898", "WBGene00077701", "Q21427", "WBGene00010775" ] }, "reaction_10646108": { "compartment": "compartment_70101", "id": "reaction_10646108", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_5652213" ], "products": [ "species_70106", "species_73473", "species_29532" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10622852": { "compartment": "compartment_70101", "id": "reaction_10622852", "reactome": "R-CEL-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622850" ], "products": [ "species_10599579", "species_76577" ], "modifiers": [], "additional_components": [ "species_76577", "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696" ] }, "reaction_10659921": { "compartment": "compartment_5460", "id": "reaction_10659921", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524038", "species_113559" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10659918", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10606630": { "compartment": "compartment_7660", "id": "reaction_10606630", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602999" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00011543", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10632627": { "compartment": "compartment_161320", "id": "reaction_10632627", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10632624", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10650017": { "compartment": "compartment_70101", "id": "reaction_10650017", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784964", "species_29356" ], "products": [ "species_561052", "species_29702" ], "modifiers": [ [ "species_10650014", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10632606": { "compartment": "compartment_161320", "id": "reaction_10632606", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10632603", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10604965": { "compartment": "compartment_70101", "id": "reaction_10604965", "reactome": "R-CEL-112033", "name": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_500172", "species_29372" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:28997", "species_83927", "U4PSA1", "WBGene00019298" ] }, "reaction_10630856": { "compartment": "compartment_5460", "id": "reaction_10630856", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113521" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620269": { "compartment": "compartment_984", "id": "reaction_10620269", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10620266", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10599499": { "compartment": "compartment_70101", "id": "reaction_10599499", "reactome": "R-CEL-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10599496", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10660470": { "compartment": "compartment_5668575", "id": "reaction_10660470", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10660467", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10623783": { "compartment": "compartment_5460", "id": "reaction_10623783", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_113552", "species_113529", "species_113593" ], "products": [ "species_31339", "species_113548", "species_113563", "species_113581" ], "modifiers": [ [ "species_10623780", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10633623": { "compartment": "compartment_70101", "id": "reaction_10633623", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10603991": { "compartment": "compartment_5460", "id": "reaction_10603991", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10633658": { "compartment": "compartment_70101", "id": "reaction_10633658", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629746", "species_29356" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633578": { "compartment": "compartment_70101", "id": "reaction_10633578", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023943", "species_29356" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10633566", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10598621": { "compartment": "compartment_70101", "id": "reaction_10598621", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598618", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "G5EBJ7", "WBGene00001404", "species_109496" ] }, "reaction_10635652": { "compartment": "compartment_7660", "id": "reaction_10635652", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632943", "species_10635648" ], "products": [ "species_10632941", "species_10635650" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10620130": { "compartment": "compartment_70101", "id": "reaction_10620130", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10620127", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10602133": { "compartment": "compartment_5460", "id": "reaction_10602133", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10602130", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10604815": { "compartment": "compartment_70101", "id": "reaction_10604815", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10604793" ], "products": [ "species_10604790", "species_111745" ], "modifiers": [ [ "species_10604793", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10598741": { "compartment": "compartment_5460", "id": "reaction_10598741", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "Q23621", "WBGene00014095" ] }, "reaction_10633764": { "compartment": "compartment_70101", "id": "reaction_10633764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10635606": { "compartment": "compartment_17957", "id": "reaction_10635606", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10651363": { "compartment": "compartment_70101", "id": "reaction_10651363", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29642", "species_29356" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10651360", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10664533": { "compartment": "compartment_17963", "id": "reaction_10664533", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10601948": { "compartment": "compartment_5460", "id": "reaction_10601948", "reactome": "R-CEL-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10601673": { "compartment": "compartment_70101", "id": "reaction_10601673", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109382", "species_111355" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10601670", "catalyst" ] ], "additional_components": [ "Q9N588", "WBGene00022455", "species_109496" ] }, "reaction_10599471": { "compartment": "compartment_70101", "id": "reaction_10599471", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10599468", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10649413": { "compartment": "compartment_5460", "id": "reaction_10649413", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5690531", "species_113593" ], "products": [ "species_159448", "species_5690542", "species_159450" ], "modifiers": [ [ "species_10649410", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10633309": { "compartment": "compartment_171062", "id": "reaction_10633309", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806238", "species_29356" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10602123": { "compartment": "compartment_5460", "id": "reaction_10602123", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10602120", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10615281": { "compartment": "compartment_5460", "id": "reaction_10615281", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10615278", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10604557": { "compartment": "compartment_70101", "id": "reaction_10604557", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "species_727810", "species_76577", "species_109378", "species_109386", "Q09629", "WBGene00014058" ] }, "reaction_10637079": { "compartment": "compartment_70101", "id": "reaction_10637079", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10666203": { "compartment": "compartment_70101", "id": "reaction_10666203", "reactome": "R-CEL-9731661", "name": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_9731609" ], "products": [ "species_9731659", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10632609": { "compartment": "compartment_161320", "id": "reaction_10632609", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632564", "species_1605610" ], "products": [ "species_10632566" ], "modifiers": [ [ "species_10632564", "catalyst" ] ], "additional_components": [ "WBGene00021095", "O02106", "WBGene00021095", "species_1605610", "WBGene00021095" ] }, "reaction_10633583": { "compartment": "compartment_70101", "id": "reaction_10633583", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10649455": { "compartment": "compartment_5460", "id": "reaction_10649455", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10649452", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10648824": { "compartment": "compartment_12045", "id": "reaction_10648824", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10648821", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10656394": { "compartment": "compartment_70101", "id": "reaction_10656394", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656386" ], "products": [ "species_10656392" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00021683", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10603953": { "compartment": "compartment_5460", "id": "reaction_10603953", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10603950", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10660930": { "compartment": "compartment_70101", "id": "reaction_10660930", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10660927", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10598766": { "compartment": "compartment_5460", "id": "reaction_10598766", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10630854": { "compartment": "compartment_5460", "id": "reaction_10630854", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_29376", "species_113521" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10649384": { "compartment": "compartment_70101", "id": "reaction_10649384", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29666" ], "products": [ "species_191293", "species_111294", "species_76577" ], "modifiers": [ [ "species_10649381", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10664694": { "compartment": "compartment_17963", "id": "reaction_10664694", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10598427": { "compartment": "compartment_70101", "id": "reaction_10598427", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10598424", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10635656": { "compartment": "compartment_70101", "id": "reaction_10635656", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632931", "species_10614210" ], "products": [ "species_10632933" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10657379": { "compartment": "compartment_12045", "id": "reaction_10657379", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598731": { "compartment": "compartment_70101", "id": "reaction_10598731", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76213", "species_29404" ], "products": [ "species_29448", "species_29406" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10610944": { "compartment": "compartment_70101", "id": "reaction_10610944", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10646517": { "compartment": "compartment_5668572", "id": "reaction_10646517", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10614529": { "compartment": "compartment_17960", "id": "reaction_10614529", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10614526", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10665612": { "compartment": "compartment_70101", "id": "reaction_10665612", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10655768": { "compartment": "compartment_70101", "id": "reaction_10655768", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10655765", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10601685": { "compartment": "compartment_70101", "id": "reaction_10601685", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10613756": { "compartment": "compartment_984", "id": "reaction_10613756", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10599279": { "compartment": "compartment_5460", "id": "reaction_10599279", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10599276", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10632693": { "compartment": "compartment_161320", "id": "reaction_10632693", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10649944": { "compartment": "compartment_5460", "id": "reaction_10649944", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10649941", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10623815": { "compartment": "compartment_70101", "id": "reaction_10623815", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_113578" ], "products": [ "species_29602", "species_29366", "species_31633" ], "modifiers": [ [ "species_10623812", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10646519": { "compartment": "compartment_5668572", "id": "reaction_10646519", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10630837": { "compartment": "compartment_70101", "id": "reaction_10630837", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620211": { "compartment": "compartment_70101", "id": "reaction_10620211", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10656412": { "compartment": "compartment_70101", "id": "reaction_10656412", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10633755": { "compartment": "compartment_876", "id": "reaction_10633755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633752", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "Q17848", "WBGene00002146" ] }, "reaction_10647415": { "compartment": "compartment_70101", "id": "reaction_10647415", "reactome": "R-CEL-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "CHEBI:16427", "CHEBI:18392", "CHEBI:16427", "CHEBI:18392", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10605609": { "compartment": "compartment_17957", "id": "reaction_10605609", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10605606", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10636567": { "compartment": "compartment_5460", "id": "reaction_10636567", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636563", "species_10630212" ], "products": [ "species_10636565", "species_10630208", "species_113529" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_31649", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9U1X0", "WBGene00013376", "species_113596", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10666187": { "compartment": "compartment_70101", "id": "reaction_10666187", "reactome": "R-CEL-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10614764": { "compartment": "compartment_876", "id": "reaction_10614764", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10614761", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10601653": { "compartment": "compartment_70101", "id": "reaction_10601653", "reactome": "R-CEL-73596", "name": "dCMP + H2O => dUMP + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_109378", "species_29356" ], "products": [ "species_109382", "species_31633" ], "modifiers": [ [ "species_10601650", "catalyst" ] ], "additional_components": [ "P30648", "WBGene00014034" ] }, "reaction_10615392": { "compartment": "compartment_70101", "id": "reaction_10615392", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10647362": { "compartment": "compartment_70101", "id": "reaction_10647362", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10647359", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10633327": { "compartment": "compartment_171062", "id": "reaction_10633327", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10633169", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10620557": { "compartment": "compartment_20699", "id": "reaction_10620557", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10620554", "catalyst" ] ], "additional_components": [ "WBGene00004894" ] }, "reaction_10606787": { "compartment": "compartment_5460", "id": "reaction_10606787", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606782" ], "products": [ "species_113521", "species_10606784" ], "modifiers": [ [ "species_10606782", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10662486": { "compartment": "compartment_5460", "id": "reaction_10662486", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10662483", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10606790": { "compartment": "compartment_5460", "id": "reaction_10606790", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606784", "species_163953" ], "products": [ "species_10606780", "species_113529", "species_113593" ], "modifiers": [ [ "species_10606784", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10599491": { "compartment": "compartment_70101", "id": "reaction_10599491", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10620185": { "compartment": "compartment_70101", "id": "reaction_10620185", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10651159": { "compartment": "compartment_5460", "id": "reaction_10651159", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651143", "species_10649049" ], "products": [ "species_10649051", "species_10651151" ], "modifiers": [ [ "species_10651156", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00009918", "WBGene00009918", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00001590" ] }, "reaction_10620261": { "compartment": "compartment_70101", "id": "reaction_10620261", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10656406": { "compartment": "compartment_70101", "id": "reaction_10656406", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656402" ], "products": [ "species_10656404" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00003477", "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10662852": { "compartment": "compartment_70101", "id": "reaction_10662852", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10662849", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10657682": { "compartment": "compartment_528865", "id": "reaction_10657682", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851509", "species_8851517" ], "products": [ "species_8851518", "species_8851513", "species_5228597" ], "modifiers": [ [ "species_10657679", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_29470", "species_29420", "species_205687", "CHEBI:58069", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10630215": { "compartment": "compartment_5460", "id": "reaction_10630215", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630201", "species_379721", "species_10630208" ], "products": [ "species_379697", "species_10630210", "species_10630212" ], "modifiers": [ [ "species_10630201", "catalyst" ], [ "species_10630208", "catalyst" ] ], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "CHEBI:33739", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33737", "Q9NA32", "WBGene00013532", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10662828": { "compartment": "compartment_12045", "id": "reaction_10662828", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10662825", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10657539": { "compartment": "compartment_70101", "id": "reaction_10657539", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10657536", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_5334668", "species_6810408", "species_1806200", "WBGene00012353" ] }, "reaction_10651392": { "compartment": "compartment_5460", "id": "reaction_10651392", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10651389", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10633516": { "compartment": "compartment_70101", "id": "reaction_10633516", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10657655": { "compartment": "compartment_17963", "id": "reaction_10657655", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851227", "species_425969", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "species_109366", "species_727810", "species_109402", "species_113578", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10599431": { "compartment": "compartment_70101", "id": "reaction_10599431", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_29424", "species_31311" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10615273": { "compartment": "compartment_70101", "id": "reaction_10615273", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372364", "species_76190" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10601717": { "compartment": "compartment_70101", "id": "reaction_10601717", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10601714", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10599461": { "compartment": "compartment_70101", "id": "reaction_10599461", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10599458", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10633638": { "compartment": "compartment_70101", "id": "reaction_10633638", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10598867": { "compartment": "compartment_5460", "id": "reaction_10598867", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10598864", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10604743": { "compartment": "compartment_70101", "id": "reaction_10604743", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10601610", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633655": { "compartment": "compartment_70101", "id": "reaction_10633655", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10599055": { "compartment": "compartment_70101", "id": "reaction_10599055", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10599052", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10612334": { "compartment": "compartment_70101", "id": "reaction_10612334", "reactome": "R-CEL-203565", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612323", "species_10612328" ], "products": [ "species_10612332" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "WBGene00007840", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10657382": { "compartment": "compartment_12045", "id": "reaction_10657382", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598828": { "compartment": "compartment_5460", "id": "reaction_10598828", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10620205": { "compartment": "compartment_70101", "id": "reaction_10620205", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10635608": { "compartment": "compartment_12045", "id": "reaction_10635608", "reactome": "R-CEL-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10611410": { "compartment": "compartment_876", "id": "reaction_10611410", "reactome": "R-CEL-200396", "name": "Creatine transport across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_200381" ], "products": [ "species_83910", "species_29916" ], "modifiers": [ [ "species_10611407", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EF43", "WBGene00004910", "G5EE39", "WBGene00004906" ] }, "reaction_10632713": { "compartment": "compartment_161320", "id": "reaction_10632713", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10632710", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10632580": { "compartment": "compartment_161320", "id": "reaction_10632580", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632566", "species_1605715" ], "products": [ "species_10632564", "species_1605641", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "O02106", "WBGene00021095", "species_1605610", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10660506": { "compartment": "compartment_5460", "id": "reaction_10660506", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660497", "species_10660485" ], "products": [ "species_10660499", "species_10660483" ], "modifiers": [ [ "species_10660504", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "Q9XTU9", "WBGene00013029", "CHEBI:33739", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:49883", "WBGene00013029", "WBGene00001033" ] }, "reaction_10650398": { "compartment": "compartment_70101", "id": "reaction_10650398", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10650395", "catalyst" ] ], "additional_components": [ "species_109496", "O01926", "WBGene00007548" ] }, "reaction_10633649": { "compartment": "compartment_70101", "id": "reaction_10633649", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10656419": { "compartment": "compartment_17951", "id": "reaction_10656419", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10656416", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10657299": { "compartment": "compartment_17957", "id": "reaction_10657299", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657295", "species_8848288" ], "products": [ "species_10657297" ], "modifiers": [], "additional_components": [ "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457", "species_164991", "species_5690542", "species_164991", "species_5690542", "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457" ] }, "reaction_10603989": { "compartment": "compartment_5460", "id": "reaction_10603989", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10602994": { "compartment": "compartment_70101", "id": "reaction_10602994", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_75973" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10602991", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10657658": { "compartment": "compartment_17963", "id": "reaction_10657658", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851233", "species_2022884" ], "products": [ "species_425969", "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29494", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10616356": { "compartment": "compartment_70101", "id": "reaction_10616356", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10599690": { "compartment": "compartment_70101", "id": "reaction_10599690", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599669" ], "products": [ "species_70113", "species_10599687" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10650252": { "compartment": "compartment_70101", "id": "reaction_10650252", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10650249", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10646508": { "compartment": "compartment_5668572", "id": "reaction_10646508", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10646505", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "species_216667", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10598380": { "compartment": "compartment_70101", "id": "reaction_10598380", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10598377", "catalyst" ] ], "additional_components": [ "O44906", "WBGene00021043", "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232" ] }, "reaction_10665624": { "compartment": "compartment_876", "id": "reaction_10665624", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10665621", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10632701": { "compartment": "compartment_161320", "id": "reaction_10632701", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606573", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632698", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10649955": { "compartment": "compartment_70101", "id": "reaction_10649955", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10649952", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10662666": { "compartment": "compartment_5460", "id": "reaction_10662666", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10649957", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10648449": { "compartment": "compartment_5460", "id": "reaction_10648449", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10648446", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q94245", "WBGene00019015", "Q9GYN3", "WBGene00020989" ] }, "reaction_10632945": { "compartment": "compartment_70101", "id": "reaction_10632945", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632933" ], "products": [ "species_10632943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10648429": { "compartment": "compartment_70101", "id": "reaction_10648429", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10648426", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "P34419", "WBGene00018370", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10666184": { "compartment": "compartment_70101", "id": "reaction_10666184", "reactome": "R-CEL-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10613760": { "compartment": "compartment_984", "id": "reaction_10613760", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10657333": { "compartment": "compartment_70101", "id": "reaction_10657333", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10657329" ], "products": [ "species_10657331" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10649964": { "compartment": "compartment_5460", "id": "reaction_10649964", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10649961", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10636076": { "compartment": "compartment_70101", "id": "reaction_10636076", "reactome": "R-CEL-2161791", "name": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142718" ], "products": [ "species_29356", "species_111745", "species_2142707" ], "modifiers": [ [ "species_10636073", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10620511": { "compartment": "compartment_70101", "id": "reaction_10620511", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620474" ], "products": [ "species_29370", "species_10620503" ], "modifiers": [ [ "species_10620508", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10648998": { "compartment": "compartment_876", "id": "reaction_10648998", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10648995", "catalyst" ] ], "additional_components": [ "Q93332", "WBGene00007954", "P91406", "WBGene00020082" ] }, "reaction_10664531": { "compartment": "compartment_17963", "id": "reaction_10664531", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10664528", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10602219": { "compartment": "compartment_70101", "id": "reaction_10602219", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q23588", "WBGene00022817" ] }, "reaction_10664696": { "compartment": "compartment_17963", "id": "reaction_10664696", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10655995": { "compartment": "compartment_13977", "id": "reaction_10655995", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10655992", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649930": { "compartment": "compartment_17951", "id": "reaction_10649930", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10649927", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10606628": { "compartment": "compartment_7660", "id": "reaction_10606628", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10606626" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10633652": { "compartment": "compartment_70101", "id": "reaction_10633652", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10623695": { "compartment": "compartment_876", "id": "reaction_10623695", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10623692", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10646096": { "compartment": "compartment_70101", "id": "reaction_10646096", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636042": { "compartment": "compartment_70101", "id": "reaction_10636042", "reactome": "R-CEL-2161187", "name": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9731626", "species_29356" ], "products": [ "species_29602", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10650368": { "compartment": "compartment_5460", "id": "reaction_10650368", "reactome": "R-CEL-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10650365", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00014058" ] }, "reaction_10654704": { "compartment": "compartment_70101", "id": "reaction_10654704", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6799497" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10654701", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10604818": { "compartment": "compartment_70101", "id": "reaction_10604818", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10665619": { "compartment": "compartment_70101", "id": "reaction_10665619", "reactome": "R-CEL-9661408", "name": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444" ], "products": [ "species_71185" ], "modifiers": [ [ "species_10665616", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10630839": { "compartment": "compartment_876", "id": "reaction_10630839", "reactome": "R-CEL-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10648813": { "compartment": "compartment_70101", "id": "reaction_10648813", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10648810", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10633718": { "compartment": "compartment_70101", "id": "reaction_10633718", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10651186": { "compartment": "compartment_5460", "id": "reaction_10651186", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_10651176", "species_2162265" ], "products": [ "species_6793613", "species_379705", "species_10649049" ], "modifiers": [ [ "species_10651183", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10633187": { "compartment": "compartment_171062", "id": "reaction_10633187", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10664715": { "compartment": "compartment_17963", "id": "reaction_10664715", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10664712", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10603993": { "compartment": "compartment_5460", "id": "reaction_10603993", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10649064": { "compartment": "compartment_5460", "id": "reaction_10649064", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10649049" ], "products": [ "species_29376", "species_10649053" ], "modifiers": [ [ "species_10649061", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10599420": { "compartment": "compartment_5460", "id": "reaction_10599420", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_35139", "species_113533" ], "products": [ "species_29376", "species_113536", "species_113546" ], "modifiers": [ [ "species_10599417", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_113531", "species_198836" ] }, "reaction_10599822": { "compartment": "compartment_70101", "id": "reaction_10599822", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10599819", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10599453": { "compartment": "compartment_70101", "id": "reaction_10599453", "reactome": "R-CEL-71261", "name": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31369", "species_29368", "species_29406" ], "products": [ "species_113528", "species_30235", "species_29434" ], "modifiers": [ [ "species_10599450", "catalyst" ] ], "additional_components": [ "Q19000", "WBGene00001522", "species_113531", "species_198836" ] }, "reaction_10599771": { "compartment": "compartment_70101", "id": "reaction_10599771", "reactome": "R-CEL-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10617719": { "compartment": "compartment_17951", "id": "reaction_10617719", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10617716", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10604547": { "compartment": "compartment_70101", "id": "reaction_10604547", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500077", "species_29370" ], "products": [ "species_500071", "species_113592" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58595", "CHEBI:57673", "species_113578", "WBGene00020190" ] }, "reaction_10632681": { "compartment": "compartment_876", "id": "reaction_10632681", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632678", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_109496" ] }, "reaction_10632559": { "compartment": "compartment_17938", "id": "reaction_10632559", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605592", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632556", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "G5ECR8", "WBGene00008706" ] }, "reaction_10606619": { "compartment": "compartment_7660", "id": "reaction_10606619", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602960" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00009342", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10612354": { "compartment": "compartment_24337", "id": "reaction_10612354", "reactome": "R-CEL-203625", "name": "NOSTRIN mediated translocation of eNOS from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612332" ], "products": [ "species_10612352" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "species_29870", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10606598": { "compartment": "compartment_7660", "id": "reaction_10606598", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10606592" ], "products": [ "species_10606596" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10599269": { "compartment": "compartment_5460", "id": "reaction_10599269", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10610962": { "compartment": "compartment_70101", "id": "reaction_10610962", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10610959", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10634928": { "compartment": "compartment_70101", "id": "reaction_10634928", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_2023974", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10617792": { "compartment": "compartment_17951", "id": "reaction_10617792", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633285": { "compartment": "compartment_171062", "id": "reaction_10633285", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10599247": { "compartment": "compartment_5460", "id": "reaction_10599247", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10599244", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864" ] }, "reaction_10663251": { "compartment": "compartment_70101", "id": "reaction_10663251", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10598857": { "compartment": "compartment_5460", "id": "reaction_10598857", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10665960": { "compartment": "compartment_70101", "id": "reaction_10665960", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10620182", "catalyst" ], [ "species_10665958", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "LigandDisplayForward?ligandId=6625", "LigandDisplayForward?ligandId=10641", "LigandDisplayForward?ligandId=10219", "Q18425", "WBGene00007918", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10633210": { "compartment": "compartment_171062", "id": "reaction_10633210", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806180" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10620172": { "compartment": "compartment_70101", "id": "reaction_10620172", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10620169", "catalyst" ] ], "additional_components": [ "Q7Z139", "WBGene00002044", "G5ED45", "WBGene00002043", "Q9XWE9", "WBGene00006505" ] }, "reaction_10603843": { "compartment": "compartment_70101", "id": "reaction_10603843", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10603840", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10604119": { "compartment": "compartment_70101", "id": "reaction_10604119", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10604116", "catalyst" ] ], "additional_components": [ "species_109382", "species_109366", "species_727810", "species_109378", "species_109402", "species_83928", "CHEBI:17562", "CHEBI:16704", "CHEBI:16450", "CHEBI:15698", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775", "species_109496" ] }, "reaction_10658877": { "compartment": "compartment_70101", "id": "reaction_10658877", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10613692": { "compartment": "compartment_984", "id": "reaction_10613692", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10602198": { "compartment": "compartment_70101", "id": "reaction_10602198", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83927", "CHEBI:17172", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10664494": { "compartment": "compartment_17963", "id": "reaction_10664494", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605607" ], "products": [ "species_9605394", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10633555": { "compartment": "compartment_70101", "id": "reaction_10633555", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10601623": { "compartment": "compartment_70101", "id": "reaction_10601623", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10599804": { "compartment": "compartment_5460", "id": "reaction_10599804", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10603975": { "compartment": "compartment_5460", "id": "reaction_10603975", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77330", "species_113526" ], "products": [ "species_77328", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10602168": { "compartment": "compartment_70101", "id": "reaction_10602168", "reactome": "R-CEL-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10602165", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10614865": { "compartment": "compartment_70101", "id": "reaction_10614865", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10633254": { "compartment": "compartment_171062", "id": "reaction_10633254", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10633615": { "compartment": "compartment_70101", "id": "reaction_10633615", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10633612", "catalyst" ] ], "additional_components": [ "G5ED01", "WBGene00012148", "species_29360" ] }, "reaction_10651384": { "compartment": "compartment_5460", "id": "reaction_10651384", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10599091", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10599083": { "compartment": "compartment_5460", "id": "reaction_10599083", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10613678": { "compartment": "compartment_70101", "id": "reaction_10613678", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10613675", "catalyst" ] ], "additional_components": [ "P90986", "WBGene00000296", "species_113531" ] }, "reaction_10649079": { "compartment": "compartment_5460", "id": "reaction_10649079", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649066", "species_113526" ], "products": [ "species_29362", "species_113529", "species_10649049" ], "modifiers": [ [ "species_10649076", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10656390": { "compartment": "compartment_70101", "id": "reaction_10656390", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656386", "species_10633085" ], "products": [ "species_10656388" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10649087": { "compartment": "compartment_12045", "id": "reaction_10649087", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694080", "species_29356" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10649084", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10617777": { "compartment": "compartment_17951", "id": "reaction_10617777", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10617774", "catalyst" ] ], "additional_components": [ "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10643266": { "compartment": "compartment_70101", "id": "reaction_10643266", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_202124", "species_10643261" ], "products": [ "species_29366", "species_432031", "species_10643259" ], "modifiers": [ [ "species_10643261", "catalyst" ] ], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10611257": { "compartment": "compartment_70101", "id": "reaction_10611257", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10603987": { "compartment": "compartment_5460", "id": "reaction_10603987", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77337", "species_113596" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604559": { "compartment": "compartment_70101", "id": "reaction_10604559", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "Q09629", "WBGene00014058" ] }, "reaction_10613762": { "compartment": "compartment_984", "id": "reaction_10613762", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10643233": { "compartment": "compartment_70101", "id": "reaction_10643233", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10643230", "catalyst" ] ], "additional_components": [ "A0A3P6NP42", "WBGene00018632", "Q21333", "WBGene00010666" ] }, "reaction_10657675": { "compartment": "compartment_984", "id": "reaction_10657675", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851462", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851461" ], "modifiers": [ [ "species_10657672", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58280", "CHEBI:58069", "species_205687", "species_727810", "species_29602", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10665627": { "compartment": "compartment_70101", "id": "reaction_10665627", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10632920": { "compartment": "compartment_876", "id": "reaction_10632920", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632917", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10656848": { "compartment": "compartment_876", "id": "reaction_10656848", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10656845", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10660188": { "compartment": "compartment_70101", "id": "reaction_10660188", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10660185", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10599086": { "compartment": "compartment_5460", "id": "reaction_10599086", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10625272": { "compartment": "compartment_70101", "id": "reaction_10625272", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10648833": { "compartment": "compartment_70101", "id": "reaction_10648833", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10648830", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10602145": { "compartment": "compartment_70101", "id": "reaction_10602145", "reactome": "R-CEL-74213", "name": "APRT catalyzes the conversion of adenine to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10602142", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10615271": { "compartment": "compartment_70101", "id": "reaction_10615271", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10615268", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10636569": { "compartment": "compartment_5460", "id": "reaction_10636569", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636565", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10636563" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_113596", "Q9U1X0", "WBGene00013376", "species_31649" ] }, "reaction_10634926": { "compartment": "compartment_70101", "id": "reaction_10634926", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023974", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10613746": { "compartment": "compartment_876", "id": "reaction_10613746", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10601727": { "compartment": "compartment_7660", "id": "reaction_10601727", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10601724", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10636096": { "compartment": "compartment_70101", "id": "reaction_10636096", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_2142716", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10650343": { "compartment": "compartment_70101", "id": "reaction_10650343", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10650340", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150", "species_109496" ] }, "reaction_10632912": { "compartment": "compartment_876", "id": "reaction_10632912", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429807" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10632909", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10630220": { "compartment": "compartment_5460", "id": "reaction_10630220", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630218", "species_113531" ], "products": [ "species_10630201" ], "modifiers": [], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10632619": { "compartment": "compartment_161320", "id": "reaction_10632619", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10632616", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10623707": { "compartment": "compartment_70101", "id": "reaction_10623707", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10623704", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10638225": { "compartment": "compartment_5460", "id": "reaction_10638225", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10638222", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10620552": { "compartment": "compartment_876", "id": "reaction_10620552", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10620549", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q20735", "WBGene00004893", "Q9TYV2", "WBGene00021075", "Q965Q4", "WBGene00004894" ] }, "reaction_10599065": { "compartment": "compartment_70101", "id": "reaction_10599065", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10599062", "catalyst" ] ], "additional_components": [ "Q9NAE2", "WBGene00013103", "species_29360" ] }, "reaction_10613764": { "compartment": "compartment_984", "id": "reaction_10613764", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10656409": { "compartment": "compartment_70101", "id": "reaction_10656409", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10614996": { "compartment": "compartment_984", "id": "reaction_10614996", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10633833": { "compartment": "compartment_876", "id": "reaction_10633833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10633830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10603957": { "compartment": "compartment_5460", "id": "reaction_10603957", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77300", "species_113526" ], "products": [ "species_77302", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10630813": { "compartment": "compartment_876", "id": "reaction_10630813", "reactome": "R-CEL-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10656977": { "compartment": "compartment_12045", "id": "reaction_10656977", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6814253", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10656974", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10648910": { "compartment": "compartment_876", "id": "reaction_10648910", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351626", "species_352327" ], "products": [ "species_351629", "species_351628" ], "modifiers": [ [ "species_10648907", "catalyst" ] ], "additional_components": [ "WBGene00000253" ] }, "reaction_10598764": { "compartment": "compartment_70101", "id": "reaction_10598764", "reactome": "R-CEL-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10598761", "catalyst" ] ], "additional_components": [ "O16924", "WBGene00003816" ] }, "reaction_10632599": { "compartment": "compartment_161320", "id": "reaction_10632599", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10650163": { "compartment": "compartment_70101", "id": "reaction_10650163", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29452" ], "products": [ "species_110096", "species_6785915" ], "modifiers": [ [ "species_10650160", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10604827": { "compartment": "compartment_70101", "id": "reaction_10604827", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10643238": { "compartment": "compartment_70101", "id": "reaction_10643238", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643235", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10643204": { "compartment": "compartment_70101", "id": "reaction_10643204", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643195", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10642609": { "compartment": "compartment_70101", "id": "reaction_10642609", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642600" ], "products": [ "species_10642607" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10642621": { "compartment": "compartment_70101", "id": "reaction_10642621", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642617" ], "products": [ "species_10642619" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10643246": { "compartment": "compartment_70101", "id": "reaction_10643246", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10643243", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10660687": { "compartment": "compartment_70101", "id": "reaction_10660687", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10660684", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29612", "species_29444", "species_29468", "WBGene00021546" ] }, "reaction_10643218": { "compartment": "compartment_70101", "id": "reaction_10643218", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643215", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10606449": { "compartment": "compartment_7660", "id": "reaction_10606449", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10606444" ], "products": [ "species_113582", "species_10606447" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10617413": { "compartment": "compartment_70616", "id": "reaction_10617413", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10617410", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281", "O17895", "WBGene00001813" ] }, "reaction_10647412": { "compartment": "compartment_70101", "id": "reaction_10647412", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_352022", "species_29356" ], "products": [ "species_29370", "species_188972", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10630680": { "compartment": "compartment_70101", "id": "reaction_10630680", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10630677", "catalyst" ] ], "additional_components": [ "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411", "Q9XW61", "WBGene00003414", "Q95QV2", "WBGene00000477", "Q19048", "WBGene00003409" ] }, "reaction_10658922": { "compartment": "compartment_70101", "id": "reaction_10658922", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658885" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10630270": { "compartment": "compartment_17906", "id": "reaction_10630270", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_113592", "species_29356" ], "products": [ "species_1369027", "species_29370", "species_29372" ], "modifiers": [ [ "species_10630267", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10658934": { "compartment": "compartment_876", "id": "reaction_10658934", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883" ], "products": [ "species_10617481" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10642580": { "compartment": "compartment_70101", "id": "reaction_10642580", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5223341", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_5223344" ], "modifiers": [ [ "species_10642577", "catalyst" ] ], "additional_components": [ "O44897", "WBGene00001819" ] }, "reaction_10642630": { "compartment": "compartment_70101", "id": "reaction_10642630", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642626", "species_10601197" ], "products": [ "species_10642628" ], "modifiers": [], "additional_components": [ "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19554", "WBGene00006512", "Q21230", "WBGene00010560" ] }, "reaction_10617438": { "compartment": "compartment_17947", "id": "reaction_10617438", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10617435", "catalyst" ] ], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061" ] }, "reaction_10617484": { "compartment": "compartment_876", "id": "reaction_10617484", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_29356" ], "products": [ "species_29370", "species_425425", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10658920": { "compartment": "compartment_12045", "id": "reaction_10658920", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883", "species_10658909" ], "products": [ "species_10658915" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10617469": { "compartment": "compartment_17947", "id": "reaction_10617469", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617467", "species_10617443" ], "products": [ "species_10617435", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "P34453", "WBGene00004201", "WBGene00004193", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "WBGene00004193", "WBGene00004201" ] }, "reaction_10658918": { "compartment": "compartment_12045", "id": "reaction_10658918", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658915", "species_10597908" ], "products": [ "species_10658911" ], "modifiers": [ [ "species_10658915", "catalyst" ] ], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10658913": { "compartment": "compartment_12045", "id": "reaction_10658913", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658911", "species_29356" ], "products": [ "species_29370", "species_10658885", "species_29372", "species_10658909" ], "modifiers": [], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10647530": { "compartment": "compartment_70101", "id": "reaction_10647530", "reactome": "R-CEL-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10647527", "catalyst" ] ], "additional_components": [ "Q9TXV8", "WBGene00000022", "Q9XW49", "WBGene00000023", "Q1RS86", "WBGene00000020", "P34358", "WBGene00000421" ] }, "reaction_10615447": { "compartment": "compartment_70101", "id": "reaction_10615447", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440" ], "products": [ "species_10615444", "species_10615442" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10625999": { "compartment": "compartment_20699", "id": "reaction_10625999", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_113592", "species_29356" ], "products": [ "species_29370", "species_167012", "species_29372" ], "modifiers": [ [ "species_10625996", "catalyst" ] ], "additional_components": [ "G5EDU1", "WBGene00004063", "species_109496" ] }, "reaction_10638045": { "compartment": "compartment_17927", "id": "reaction_10638045", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889081", "species_113529" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10638042", "catalyst" ] ], "additional_components": [ "species_74113", "species_425815", "species_74113", "species_425815", "WBGene00009617" ] }, "reaction_10619535": { "compartment": "compartment_171062", "id": "reaction_10619535", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10619530", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10622391": { "compartment": "compartment_70101", "id": "reaction_10622391", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637543": { "compartment": "compartment_70101", "id": "reaction_10637543", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637540", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10626047": { "compartment": "compartment_876", "id": "reaction_10626047", "reactome": "R-CEL-937311", "name": "ATP12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10626044", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10656840": { "compartment": "compartment_70101", "id": "reaction_10656840", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10656837", "catalyst" ] ], "additional_components": [ "Q7JMM5", "WBGene00017515", "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q94187", "WBGene00017515" ] }, "reaction_10638040": { "compartment": "compartment_984", "id": "reaction_10638040", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10638037", "catalyst" ] ], "additional_components": [ "Q9XU88", "WBGene00010214", "Q20273", "WBGene00009617", "G5EFS0", "WBGene00009618" ] }, "reaction_10620374": { "compartment": "compartment_876", "id": "reaction_10620374", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10620371", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10629117": { "compartment": "compartment_984", "id": "reaction_10629117", "reactome": "R-CEL-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10615975": { "compartment": "compartment_876", "id": "reaction_10615975", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_113538", "species_159549", "WBGene00012804" ] }, "reaction_10637530": { "compartment": "compartment_70101", "id": "reaction_10637530", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637458", "species_113592", "species_10597908" ], "products": [ "species_29370", "species_10637478", "species_947590" ], "modifiers": [ [ "species_10637516", "catalyst" ], [ "species_10637522", "catalyst" ] ], "additional_components": [ "Q19777", "WBGene00009109", "WBGene00006727", "Q19777", "WBGene00009109", "G4S4W1", "WBGene00016980", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "Q07292", "WBGene00003030", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "WBGene00006941" ] }, "reaction_10626107": { "compartment": "compartment_876", "id": "reaction_10626107", "reactome": "R-CEL-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947594", "species_113592", "species_29356" ], "products": [ "species_29370", "species_947588", "species_29372" ], "modifiers": [ [ "species_10626104", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1524083", "species_1500646", "species_1524083", "P91203", "WBGene00017174", "Q9U280", "WBGene00013034", "O18182", "WBGene00012360", "U4PBV8", "WBGene00019166", "Q7JPE3", "WBGene00020784", "G5EBH1", "WBGene00009498" ] }, "reaction_10615157": { "compartment": "compartment_876", "id": "reaction_10615157", "reactome": "R-CEL-352364", "name": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352036", "species_74113" ], "products": [ "species_83910", "species_352359", "species_74113", "species_29432" ], "modifiers": [ [ "species_10615150", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_352002", "species_351990", "species_29432", "species_111707", "species_352002", "species_351990", "WBGene00001622" ] }, "reaction_10637617": { "compartment": "compartment_70101", "id": "reaction_10637617", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2730999" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10637614", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10659515": { "compartment": "compartment_876", "id": "reaction_10659515", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10625831": { "compartment": "compartment_947586", "id": "reaction_10625831", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10642981": { "compartment": "compartment_70101", "id": "reaction_10642981", "reactome": "R-CEL-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10642978", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10643209": { "compartment": "compartment_70101", "id": "reaction_10643209", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622382", "catalyst" ], [ "species_10643207", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q20734", "WBGene00043980", "WBGene00002881" ] }, "reaction_10662986": { "compartment": "compartment_70101", "id": "reaction_10662986", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662983", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10619506": { "compartment": "compartment_876", "id": "reaction_10619506", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112", "species_74126" ], "modifiers": [ [ "species_10619503", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10663007": { "compartment": "compartment_70101", "id": "reaction_10663007", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10663004", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10620458": { "compartment": "compartment_876", "id": "reaction_10620458", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10616007": { "compartment": "compartment_876", "id": "reaction_10616007", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10616004", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_29432", "species_113538", "species_159549", "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10620122": { "compartment": "compartment_201753", "id": "reaction_10620122", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10620119", "catalyst" ] ], "additional_components": [ "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556" ] }, "reaction_10620250": { "compartment": "compartment_201753", "id": "reaction_10620250", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_428592" ], "products": [ "species_70106", "species_428632" ], "modifiers": [ [ "species_10620247", "catalyst" ] ], "additional_components": [ "species_352003", "species_159549", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10637656": { "compartment": "compartment_70101", "id": "reaction_10637656", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637653", "catalyst" ] ], "additional_components": [ "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528", "G5EG93", "WBGene00000529", "Q9BMK9", "WBGene00000530" ] }, "reaction_10639280": { "compartment": "compartment_70101", "id": "reaction_10639280", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639277", "catalyst" ] ], "additional_components": [ "P34586", "WBGene00006614", "G5EDR9", "WBGene00003838", "Q22374", "WBGene00003840", "Q8T666", "WBGene00000846", "O61220", "WBGene00003839", "Q20766", "WBGene00001796", "P34641", "WBGene00000425", "Q8I6Y9", "WBGene00006615", "G5EF09", "WBGene00004976", "Q23141", "WBGene00020972", "Q9N3Y9", "WBGene00003841", "G5ECM4", "WBGene00001795", "Q93971", "WBGene00001651", "Q19377", "WBGene00008731" ] }, "reaction_10620097": { "compartment": "compartment_876", "id": "reaction_10620097", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10620094", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "WBGene00003876" ] }, "reaction_10663009": { "compartment": "compartment_70101", "id": "reaction_10663009", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637671": { "compartment": "compartment_70101", "id": "reaction_10637671", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637668", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10648663": { "compartment": "compartment_70101", "id": "reaction_10648663", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10648656", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10665480": { "compartment": "compartment_876", "id": "reaction_10665480", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665478", "species_351626" ], "products": [ "species_10637417" ], "modifiers": [], "additional_components": [ "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "Q10025", "WBGene00020897", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465" ] }, "reaction_10658135": { "compartment": "compartment_876", "id": "reaction_10658135", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658125" ], "products": [ "species_10658133" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10619627": { "compartment": "compartment_876", "id": "reaction_10619627", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10619624", "catalyst" ] ], "additional_components": [ "G5EBK1", "WBGene00003943", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10637666": { "compartment": "compartment_70101", "id": "reaction_10637666", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637661", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10637927": { "compartment": "compartment_70101", "id": "reaction_10637927", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10637915", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10658393": { "compartment": "compartment_876", "id": "reaction_10658393", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658389", "species_10637417" ], "products": [ "species_10658391" ], "modifiers": [], "additional_components": [ "Q7YZV6", "WBGene00006067", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "Q7YZV6", "WBGene00006067", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064" ] }, "reaction_10607855": { "compartment": "compartment_74700", "id": "reaction_10607855", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607851" ], "products": [ "species_10607853" ], "modifiers": [], "additional_components": [ "WBGene00020481", "WBGene00020481" ] }, "reaction_10637985": { "compartment": "compartment_70101", "id": "reaction_10637985", "reactome": "R-CEL-2855020", "name": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2855229" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10637970", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_74016", "catalyst" ], [ "species_10637983", "inhibitor" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "Q20203", "WBGene00000822", "A8WHT8", "WBGene00010703", "A0A2C9C3E8", "WBGene00006801", "Q9U2Q8", "WBGene00001427", "O45405", "WBGene00001371", "Q8WQA4", "WBGene00001365", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10619715": { "compartment": "compartment_876", "id": "reaction_10619715", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_188972", "species_74126" ], "modifiers": [ [ "species_10619712", "catalyst" ] ], "additional_components": [ "Q09573", "WBGene00019289", "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205" ] }, "reaction_10660137": { "compartment": "compartment_12045", "id": "reaction_10660137", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660133" ], "products": [ "species_193384", "species_10660131" ], "modifiers": [], "additional_components": [ "species_8848047", "P34389", "WBGene00003562", "WBGene00003562" ] }, "reaction_10637444": { "compartment": "compartment_70101", "id": "reaction_10637444", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637417", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_10637442", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066" ] }, "reaction_10660129": { "compartment": "compartment_161320", "id": "reaction_10660129", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10660125" ], "products": [ "species_10660127" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_8848047", "O17271", "WBGene00006452" ] }, "reaction_10620016": { "compartment": "compartment_876", "id": "reaction_10620016", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620013", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10662860": { "compartment": "compartment_70101", "id": "reaction_10662860", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10662857", "catalyst" ] ], "additional_components": [ "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10620008": { "compartment": "compartment_876", "id": "reaction_10620008", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620005", "catalyst" ] ], "additional_components": [ "O17404", "WBGene00017312", "O45220", "WBGene00007141", "Q17454", "WBGene00015054", "P91840", "WBGene00012285", "Q17455", "WBGene00015055", "Q18697", "WBGene00016739" ] }, "reaction_10660180": { "compartment": "compartment_12045", "id": "reaction_10660180", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_76194", "species_8876704" ], "modifiers": [ [ "species_10660175", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10625823": { "compartment": "compartment_984", "id": "reaction_10625823", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_912516", "species_917828" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625820", "catalyst" ] ], "additional_components": [ "P34465", "WBGene00018210", "O16271", "WBGene00018210", "species_71185", "O16272", "WBGene00018210" ] }, "reaction_10615166": { "compartment": "compartment_876", "id": "reaction_10615166", "reactome": "R-CEL-352385", "name": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_83910", "species_74113", "species_29432" ], "products": [ "species_29472", "species_83910", "species_352036", "species_74113" ], "modifiers": [ [ "species_10615161", "catalyst" ] ], "additional_components": [ "WBGene00001622" ] }, "reaction_10626007": { "compartment": "compartment_20699", "id": "reaction_10626007", "reactome": "R-CEL-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10626004", "catalyst" ] ], "additional_components": [ "WBGene00000834" ] }, "reaction_10648767": { "compartment": "compartment_70101", "id": "reaction_10648767", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10648660" ], "products": [ "species_10648758" ], "modifiers": [ [ "species_10648764", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807" ] }, "reaction_10648852": { "compartment": "compartment_70101", "id": "reaction_10648852", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10648849", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10620426": { "compartment": "compartment_876", "id": "reaction_10620426", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10620423", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10666181": { "compartment": "compartment_876", "id": "reaction_10666181", "reactome": "R-CEL-9727198", "name": "ATP4A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10666178", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10631304": { "compartment": "compartment_70101", "id": "reaction_10631304", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_71067" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10621144", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10619675": { "compartment": "compartment_876", "id": "reaction_10619675", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10619672", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10665971": { "compartment": "compartment_70101", "id": "reaction_10665971", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639225", "catalyst" ] ], "additional_components": [ "G5EDR9", "WBGene00003838", "Q9N3Y9", "WBGene00003841", "Q22374", "WBGene00003840", "O61220", "WBGene00003839" ] }, "reaction_10625842": { "compartment": "compartment_947586", "id": "reaction_10625842", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10619528": { "compartment": "compartment_172574", "id": "reaction_10619528", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_425999" ], "products": [ "species_70106", "species_425977" ], "modifiers": [ [ "species_10619525", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10619514": { "compartment": "compartment_876", "id": "reaction_10619514", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_425815" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10619511", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10662981": { "compartment": "compartment_70101", "id": "reaction_10662981", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662978", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10619639": { "compartment": "compartment_20699", "id": "reaction_10619639", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10619636", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10619666": { "compartment": "compartment_876", "id": "reaction_10619666", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_74126" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10619663", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10637918": { "compartment": "compartment_70101", "id": "reaction_10637918", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637915", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10650003": { "compartment": "compartment_1660541", "id": "reaction_10650003", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649973" ], "products": [ "species_10650001" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10650005": { "compartment": "compartment_1660541", "id": "reaction_10650005", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650001" ], "products": [ "species_10649999" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10620099": { "compartment": "compartment_876", "id": "reaction_10620099", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_428027", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_427997", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ] ], "additional_components": [ "species_6810061", "species_427963", "species_113552", "species_6810061", "species_427963", "species_113552", "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10630870": { "compartment": "compartment_70101", "id": "reaction_10630870", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10622388": { "compartment": "compartment_70101", "id": "reaction_10622388", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622384" ], "products": [ "species_10622382", "species_113592" ], "modifiers": [], "additional_components": [ "species_113592", "Q20734", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10660135": { "compartment": "compartment_161320", "id": "reaction_10660135", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660127", "species_10660131" ], "products": [ "species_10660133", "species_10660125" ], "modifiers": [], "additional_components": [ "species_8848047", "O17271", "WBGene00006452", "WBGene00003562", "species_8848047", "P34389", "WBGene00003562", "WBGene00006452" ] }, "reaction_10648755": { "compartment": "compartment_5460", "id": "reaction_10648755", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10648752", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10620088": { "compartment": "compartment_12045", "id": "reaction_10620088", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_156540" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10620064", "catalyst" ], [ "species_10620086", "catalyst" ] ], "additional_components": [ "WBGene00004736", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10620519": { "compartment": "compartment_876", "id": "reaction_10620519", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10648841": { "compartment": "compartment_70101", "id": "reaction_10648841", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10648838", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10658121": { "compartment": "compartment_70101", "id": "reaction_10658121", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_71285", "species_2162265" ], "modifiers": [ [ "species_10658118", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10660027": { "compartment": "compartment_70101", "id": "reaction_10660027", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10660024", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10648776": { "compartment": "compartment_70101", "id": "reaction_10648776", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613629", "species_10648772" ], "products": [ "species_10648774" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10622386": { "compartment": "compartment_70101", "id": "reaction_10622386", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622382", "species_113592" ], "products": [ "species_10622384" ], "modifiers": [], "additional_components": [ "Q20734", "WBGene00043980", "species_113592", "Q20734", "WBGene00043980" ] }, "reaction_10637553": { "compartment": "compartment_70101", "id": "reaction_10637553", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10637548", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10648658": { "compartment": "compartment_70101", "id": "reaction_10648658", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648654", "species_5690881" ], "products": [ "species_10648656" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10607567": { "compartment": "compartment_70101", "id": "reaction_10607567", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607560" ], "products": [ "species_29370", "species_10607562" ], "modifiers": [ [ "species_10607564", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00006940" ] }, "reaction_10607608": { "compartment": "compartment_13231", "id": "reaction_10607608", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607606" ], "products": [ "species_10607600" ], "modifiers": [], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10638343": { "compartment": "compartment_70101", "id": "reaction_10638343", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605884" ], "products": [ "species_10605870" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10638290": { "compartment": "compartment_70101", "id": "reaction_10638290", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10638283" ], "products": [ "species_10638287", "species_29370", "species_10605884" ], "modifiers": [ [ "species_10638283", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198", "WBGene00010198", "WBGene00004043", "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198" ] }, "reaction_10607552": { "compartment": "compartment_13231", "id": "reaction_10607552", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607520" ], "products": [ "species_10607550" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10638363": { "compartment": "compartment_7660", "id": "reaction_10638363", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10605870" ], "products": [ "species_10638345", "species_113550" ], "modifiers": [ [ "species_10638360", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10607604": { "compartment": "compartment_7660", "id": "reaction_10607604", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607600", "species_29358" ], "products": [ "species_113582", "species_10607602" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10607584": { "compartment": "compartment_7660", "id": "reaction_10607584", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607532" ], "products": [ "species_113582", "species_10607573" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10658258": { "compartment": "compartment_7660", "id": "reaction_10658258", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630226", "species_77087" ], "products": [ "species_10658250", "species_77502" ], "modifiers": [ [ "species_10658255", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007137" ] }, "reaction_10658266": { "compartment": "compartment_7660", "id": "reaction_10658266", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658250", "species_113518" ], "products": [ "species_8857797", "species_10630226" ], "modifiers": [ [ "species_10658263", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007188" ] }, "reaction_10607569": { "compartment": "compartment_70101", "id": "reaction_10607569", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607556" ], "products": [ "species_10607560" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657946": { "compartment": "compartment_70101", "id": "reaction_10657946", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657941" ], "products": [ "species_10657884", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607598": { "compartment": "compartment_70101", "id": "reaction_10607598", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607594" ], "products": [ "species_10607596" ], "modifiers": [], "additional_components": [ "WBGene00000405", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10607580": { "compartment": "compartment_13231", "id": "reaction_10607580", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607536" ], "products": [ "species_10607496" ], "modifiers": [ [ "species_10607578", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10657944": { "compartment": "compartment_70101", "id": "reaction_10657944", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657898", "species_10597908" ], "products": [ "species_10657941" ], "modifiers": [ [ "species_10657898", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320", "WBGene00006727", "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10640968": { "compartment": "compartment_70101", "id": "reaction_10640968", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640966" ], "products": [ "species_29370", "species_10638281" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10607619": { "compartment": "compartment_13231", "id": "reaction_10607619", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607518" ], "products": [ "species_10607548" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657900": { "compartment": "compartment_70101", "id": "reaction_10657900", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657896", "species_10657884" ], "products": [ "species_10657898" ], "modifiers": [], "additional_components": [ "O01427", "WBGene00000099", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10607617": { "compartment": "compartment_70101", "id": "reaction_10607617", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607610" ], "products": [ "species_29370", "species_10607518" ], "modifiers": [ [ "species_10607614", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N2L7", "WBGene00004043", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10658008": { "compartment": "compartment_171062", "id": "reaction_10658008", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658004", "species_10657982" ], "products": [ "species_10658006" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644", "WBGene00012894", "P91857", "WBGene00004268", "Q9U2D8", "WBGene00012894", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644" ] }, "reaction_10658113": { "compartment": "compartment_262783", "id": "reaction_10658113", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658104", "species_10658109", "species_10658098" ], "products": [ "species_10658111" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "WBGene00044061", "WBGene00004274", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061", "O01803", "WBGene00004274" ] }, "reaction_10658051": { "compartment": "compartment_17938", "id": "reaction_10658051", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658049", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_111349", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271" ] }, "reaction_10658022": { "compartment": "compartment_17938", "id": "reaction_10658022", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658014", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ], [ "species_10658020", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271", "WBGene00022880" ] }, "reaction_10658045": { "compartment": "compartment_20699", "id": "reaction_10658045", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658041", "species_10657417" ], "products": [ "species_10658043" ], "modifiers": [], "additional_components": [ "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "H2KZZ6", "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10657976": { "compartment": "compartment_24339", "id": "reaction_10657976", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657953", "species_29356" ], "products": [ "species_29372", "species_10657955" ], "modifiers": [ [ "species_10657953", "catalyst" ], [ "species_10657974", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "species_29420", "Q9U2C3", "WBGene00004284", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "O44873", "WBGene00019915", "H2KZ54", "WBGene00016292" ] }, "reaction_10658036": { "compartment": "compartment_262783", "id": "reaction_10658036", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658025", "species_10658032" ], "products": [ "species_10658034" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "O44873", "WBGene00019915", "species_29438" ] }, "reaction_10646156": { "compartment": "compartment_7660", "id": "reaction_10646156", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646152", "species_10604720" ], "products": [ "species_10646154" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q19196", "WBGene00017237", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10620944": { "compartment": "compartment_70101", "id": "reaction_10620944", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10620938", "species_10608669", "species_10619297" ], "products": [ "species_10620942", "species_10614982", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "species_29438", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "species_29420", "G5EFK4", "WBGene00000183" ] }, "reaction_10646797": { "compartment": "compartment_20699", "id": "reaction_10646797", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646793", "species_10625671", "species_10608649" ], "products": [ "species_10646795" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q8WQB3", "WBGene00000158", "Q17796", "WBGene00004101" ] }, "reaction_10643083": { "compartment": "compartment_263163", "id": "reaction_10643083", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10643079" ], "products": [ "species_10643081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "P34574", "WBGene00011867", "species_5334668", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829" ] }, "reaction_10621011": { "compartment": "compartment_70101", "id": "reaction_10621011", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620942", "species_29438" ], "products": [ "species_10619299", "species_10608669", "species_29372", "species_29420", "species_10621008" ], "modifiers": [ [ "species_10620942", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q8WQB3", "WBGene00000158", "Q94057", "WBGene00044062", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "P51485", "WBGene00000195", "Q22616", "WBGene00011872", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898" ] }, "reaction_10612275": { "compartment": "compartment_70101", "id": "reaction_10612275", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612269" ], "products": [ "species_10612271", "species_10612273" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615087": { "compartment": "compartment_70101", "id": "reaction_10615087", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615078" ], "products": [ "species_10615082", "species_10615080" ], "modifiers": [ [ "species_10615084", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615118": { "compartment": "compartment_7660", "id": "reaction_10615118", "reactome": "R-CEL-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608315" ], "products": [ "species_10615095", "species_10615093" ], "modifiers": [ [ "species_10615115", "catalyst" ] ], "additional_components": [ "WBGene00009127", "WBGene00009127", "WBGene00009127", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611885": { "compartment": "compartment_70101", "id": "reaction_10611885", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611879" ], "products": [ "species_10611883", "species_10611881" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10611934": { "compartment": "compartment_70101", "id": "reaction_10611934", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611928" ], "products": [ "species_10611932", "species_10611930" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10612313": { "compartment": "compartment_70101", "id": "reaction_10612313", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612307" ], "products": [ "species_10612311", "species_10612309" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10612283": { "compartment": "compartment_70101", "id": "reaction_10612283", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612277" ], "products": [ "species_10612279", "species_10612281" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10614649": { "compartment": "compartment_7660", "id": "reaction_10614649", "reactome": "R-CEL-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614622" ], "products": [ "species_10614624", "species_10614626" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10664192": { "compartment": "compartment_13231", "id": "reaction_10664192", "reactome": "R-CEL-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664190" ], "products": [ "species_10614646" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611908": { "compartment": "compartment_70101", "id": "reaction_10611908", "reactome": "R-CEL-201634", "name": "Caspase-mediated cleavage of FADK 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901" ], "products": [ "species_10611903", "species_10611905" ], "modifiers": [ [ "species_10605385", "catalyst" ] ], "additional_components": [ "WBGene00002213", "WBGene00002213", "WBGene00002213", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611852": { "compartment": "compartment_70101", "id": "reaction_10611852", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846" ], "products": [ "species_10611848", "species_10611850" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10664170": { "compartment": "compartment_7660", "id": "reaction_10664170", "reactome": "R-CEL-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605385" ], "products": [ "species_10615115" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611844": { "compartment": "compartment_876", "id": "reaction_10611844", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611839" ], "products": [ "species_10611841" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10615122": { "compartment": "compartment_13231", "id": "reaction_10615122", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615080" ], "products": [ "species_10615120" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10614975": { "compartment": "compartment_70101", "id": "reaction_10614975", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614969" ], "products": [ "species_10614973", "species_10614971" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10611896": { "compartment": "compartment_70101", "id": "reaction_10611896", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611890" ], "products": [ "species_10611894", "species_10611892" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10611917": { "compartment": "compartment_70101", "id": "reaction_10611917", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611913" ], "products": [ "species_10611915" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10615065": { "compartment": "compartment_876", "id": "reaction_10615065", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615061" ], "products": [ "species_10615063" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615059": { "compartment": "compartment_70101", "id": "reaction_10615059", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615053" ], "products": [ "species_10615057", "species_10615055" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10615091": { "compartment": "compartment_876", "id": "reaction_10615091", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615089" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10614657": { "compartment": "compartment_7660", "id": "reaction_10614657", "reactome": "R-CEL-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614651" ], "products": [ "species_10614653", "species_10614655" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615131": { "compartment": "compartment_70101", "id": "reaction_10615131", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615127" ], "products": [ "species_10615129" ], "modifiers": [ [ "species_10615072", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10614404": { "compartment": "compartment_70101", "id": "reaction_10614404", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604948" ], "products": [ "species_10614400", "species_10614402" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10615051": { "compartment": "compartment_876", "id": "reaction_10615051", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615047" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10609819": { "compartment": "compartment_876", "id": "reaction_10609819", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_188995", "species_70113", "species_29532", "species_188995", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10609777": { "compartment": "compartment_876", "id": "reaction_10609777", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10609774", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10604700": { "compartment": "compartment_7660", "id": "reaction_10604700", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604690", "species_30555" ], "products": [ "species_10604697", "species_113541" ], "modifiers": [ [ "species_10604690", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604684": { "compartment": "compartment_7660", "id": "reaction_10604684", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604676", "species_10604680" ], "products": [ "species_10604682" ], "modifiers": [], "additional_components": [ "WBGene00018721", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604693": { "compartment": "compartment_7660", "id": "reaction_10604693", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604682", "species_29604" ], "products": [ "species_10604690", "species_113541" ], "modifiers": [ [ "species_10604682", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646366": { "compartment": "compartment_7660", "id": "reaction_10646366", "reactome": "R-CEL-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350" ], "products": [ "species_10646361", "species_10646363", "species_10646348" ], "modifiers": [ [ "species_10646350", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "WBGene00011216", "WBGene00011216", "WBGene00009441", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10646089": { "compartment": "compartment_7660", "id": "reaction_10646089", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646066", "species_10646085" ], "products": [ "species_10646087" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10646359": { "compartment": "compartment_7660", "id": "reaction_10646359", "reactome": "R-CEL-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350", "species_10646091" ], "products": [ "species_10646352" ], "modifiers": [], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646338": { "compartment": "compartment_7660", "id": "reaction_10646338", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646329", "species_29358" ], "products": [ "species_113582", "species_10646335", "species_10604676" ], "modifiers": [ [ "species_10646329", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00018721", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646331": { "compartment": "compartment_7660", "id": "reaction_10646331", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646327", "species_10646311" ], "products": [ "species_10646329" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646333": { "compartment": "compartment_7660", "id": "reaction_10646333", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604697", "species_10646309" ], "products": [ "species_10646311" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00011834", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646357": { "compartment": "compartment_7660", "id": "reaction_10646357", "reactome": "R-CEL-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646352" ], "products": [ "species_10646350", "species_10646354", "species_10597874" ], "modifiers": [ [ "species_10646352", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646094": { "compartment": "compartment_7660", "id": "reaction_10646094", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646087", "species_10597874" ], "products": [ "species_10646091", "species_10646085", "species_10604720" ], "modifiers": [ [ "species_10646087", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648209": { "compartment": "compartment_7660", "id": "reaction_10648209", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648199" ], "products": [ "species_68454", "species_10648206", "species_10598267" ], "modifiers": [ [ "species_10648199", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296" ] }, "reaction_10648197": { "compartment": "compartment_7660", "id": "reaction_10648197", "reactome": "R-CEL-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10648186" ], "products": [ "species_10648194", "species_113541" ], "modifiers": [ [ "species_10648186", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648188": { "compartment": "compartment_7660", "id": "reaction_10648188", "reactome": "R-CEL-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10648170", "species_10648180", "species_10598267" ], "products": [ "species_10648186" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "A0FLQ6", "WBGene00020964", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648202": { "compartment": "compartment_7660", "id": "reaction_10648202", "reactome": "R-CEL-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648194", "species_427523" ], "products": [ "species_10646052", "species_427497", "species_10648180", "species_10648199" ], "modifiers": [ [ "species_10648194", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "A0FLQ6", "WBGene00020964", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648173": { "compartment": "compartment_7660", "id": "reaction_10648173", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648166" ], "products": [ "species_30555", "species_10648170" ], "modifiers": [ [ "species_10648166", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10621613": { "compartment": "compartment_876", "id": "reaction_10621613", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_114523" ], "products": [ "species_83910", "species_352022", "species_209914" ], "modifiers": [ [ "species_10621610", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10617035": { "compartment": "compartment_5460", "id": "reaction_10617035", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10619309": { "compartment": "compartment_20699", "id": "reaction_10619309", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10619291", "species_10608669", "species_10619297" ], "products": [ "species_10614982", "species_10619307", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "species_29438", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10619432": { "compartment": "compartment_70101", "id": "reaction_10619432", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10619307" ], "products": [ "species_10619299", "species_10619429", "species_10608669", "species_29372", "species_29420" ], "modifiers": [ [ "species_10619307", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00001130", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9N489", "WBGene00022453", "Q9XZI6", "WBGene00006751", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "Q02328", "WBGene00022717", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10614994": { "compartment": "compartment_70101", "id": "reaction_10614994", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10614982" ], "products": [ "species_10614986", "species_29420" ], "modifiers": [ [ "species_10614991", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "species_29438", "G5EFK4", "WBGene00000183", "WBGene00007703" ] }, "reaction_10659242": { "compartment": "compartment_876", "id": "reaction_10659242", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659237", "species_29356" ], "products": [ "species_29372", "species_10659239" ], "modifiers": [ [ "species_10659237", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", 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has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10659118", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659177": { "compartment": "compartment_876", "id": "reaction_10659177", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659167", "species_10659171", "species_10608681", "species_10659141", "species_10659143", "species_10659124", "species_10659159", "species_10659118" ], "products": [ "species_10658206", "species_10633167", "species_10659175" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "Q6AHQ8", "WBGene00018467", "WBGene00003086", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "Q9TXS0", "WBGene00018974", "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898" ] }, "reaction_10659192": { "compartment": "compartment_876", "id": "reaction_10659192", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633167", "species_10659116" ], "products": [ "species_10659118" ], "modifiers": [], "additional_components": [ "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659179": { "compartment": "compartment_876", "id": "reaction_10659179", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10659114" ], "products": [ "species_10659116" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10658232": { "compartment": "compartment_876", "id": "reaction_10658232", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658218", "species_10658220", "species_10619297", "species_10658191", "species_10641905" ], "products": [ "species_10658224" ], "modifiers": [ [ "species_10658230", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "Q9BIF4", "WBGene00001224", "A0A0K3AS36", "Y116A8C.36d", "WBGene00022453", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10659190": { "compartment": "compartment_876", "id": "reaction_10659190", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10618288", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10658243": { "compartment": "compartment_876", "id": "reaction_10658243", "reactome": "R-CEL-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658224", "species_113592" ], "products": [ "species_29370", "species_10658240" ], "modifiers": [ [ "species_10658224", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10659244": { "compartment": "compartment_876", "id": "reaction_10659244", "reactome": "R-CEL-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633129", "species_10659225" ], "products": [ "species_10659237" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659409": { "compartment": "compartment_876", "id": "reaction_10659409", "reactome": "R-CEL-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10659239" ], "products": [ "species_10659402", "species_29372" ], "modifiers": [ [ "species_10659239", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", 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"WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "O76667", "WBGene00019183", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", 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"O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659815": { "compartment": "compartment_876", "id": "reaction_10659815", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619297", "species_10641905", "species_179856" ], "products": [ "species_10658214" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "species_179856" ] }, "reaction_10659813": { "compartment": "compartment_24339", "id": "reaction_10659813", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659811" ], "products": [ "species_10659460", "species_10658191" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "species_29420", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762" ] }, "reaction_10659221": { "compartment": "compartment_876", "id": "reaction_10659221", "reactome": "R-CEL-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659211", "species_10659207", "species_10659215", "species_10659175", "species_10659217", "species_10612328" ], "products": [ "species_10659219" ], "modifiers": [], "additional_components": [ "Q02328", "WBGene00022717", "species_113592", "P10984", "WBGene00000064", "Q02328", "WBGene00022717", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_113592", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "WBGene00007840", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659227": { "compartment": "compartment_876", "id": "reaction_10659227", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659223", "species_10659219" ], "products": [ "species_10659225" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10644197": { "compartment": "compartment_70101", "id": "reaction_10644197", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10644194", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10644705": { "compartment": "compartment_70101", "id": "reaction_10644705", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644685" ], "products": [ "species_29370", "species_10644703" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "WBGene00002189" ] }, "reaction_10619072": { "compartment": "compartment_204883", "id": "reaction_10619072", "reactome": "R-CEL-420598", "name": "Nectin-1:Nectin-4 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619068" ], "products": [ "species_10619070" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619066": { "compartment": "compartment_204883", "id": "reaction_10619066", "reactome": "R-CEL-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618975", "species_10611124" ], "products": [ "species_10619064" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619062": { "compartment": "compartment_204883", "id": "reaction_10619062", "reactome": "R-CEL-420580", "name": "Nectin-1:PVRL3 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619058" ], "products": [ "species_10619060" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10640549": { "compartment": "compartment_876", "id": "reaction_10640549", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612994", "species_10640545" ], "products": [ "species_10640547" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247" ] }, "reaction_10614501": { "compartment": "compartment_984", "id": "reaction_10614501", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614495", "species_10614497" ], "products": [ "species_10614499" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10640887": { "compartment": "compartment_984", "id": "reaction_10640887", "reactome": "R-CEL-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640883", "species_10631599" ], "products": [ "species_10640885" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "WBGene00006787", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q06561", "WBGene00006787", "Q21313", "WBGene00001328", "O44565", "WBGene00002247" ] }, "reaction_10614473": { "compartment": "compartment_984", "id": "reaction_10614473", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614469", "species_10614421" ], "products": [ "species_10614471" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10636750": { "compartment": "compartment_984", "id": "reaction_10636750", "reactome": "R-CEL-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_10636746" ], "products": [ "species_10636748" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "P17139", "WBGene00001263", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779" ] }, "reaction_10665322": { "compartment": "compartment_17938", "id": "reaction_10665322", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10665189" ], "products": [ "species_10665191" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665314": { "compartment": "compartment_17938", "id": "reaction_10665314", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606895", "species_10665178" ], "products": [ "species_10665189" ], "modifiers": [], "additional_components": [ "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665172": { "compartment": "compartment_17938", "id": "reaction_10665172", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165", "species_29420" ], "products": [ "species_29438", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665311": { "compartment": "compartment_17938", "id": "reaction_10665311", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165" ], "products": [ "species_29372", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ], [ "species_10665309", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "H2L0I8", "WBGene00020208", "S6FMZ4", "WBGene00017699" ] }, "reaction_10665185": { "compartment": "compartment_17938", "id": "reaction_10665185", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665180" ], "products": [ "species_10665178", "species_10665174" ], "modifiers": [], "additional_components": [ "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29468", "Q19425", "WBGene00008774" ] }, "reaction_10665187": { "compartment": "compartment_17938", "id": "reaction_10665187", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665174", "species_10665169" ], "products": [ "species_10665176" ], "modifiers": [], "additional_components": [ "species_29468", "Q19425", "WBGene00008774", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665183": { "compartment": "compartment_17938", "id": "reaction_10665183", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665176" ], "products": [ "species_10665180", "species_29420" ], "modifiers": [ [ "species_10665176", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665196": { "compartment": "compartment_17938", "id": "reaction_10665196", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665191" ], "products": [ "species_10665193", "species_29372" ], "modifiers": [ [ "species_10665191", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P91040", "WBGene00015697", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665769": { "compartment": "compartment_7660", "id": "reaction_10665769", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649795" ], "products": [ "species_113582", "species_10649806", "species_113550" ], "modifiers": [ [ "species_10649795", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649828": { "compartment": "compartment_7660", "id": "reaction_10649828", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10649814" ], "products": [ "species_10649826" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "Q18547", "WBGene00004339", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q23088", "WBGene00022812", "Q19366", "WBGene00008722", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "O62218", "WBGene00009368", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10649798": { "compartment": "compartment_7660", "id": "reaction_10649798", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649784" ], "products": [ "species_113582", "species_113550", "species_10649795" ], "modifiers": [ [ "species_10649784", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649812": { "compartment": "compartment_7660", "id": "reaction_10649812", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649808", "species_10604543" ], "products": [ "species_10649810" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649817": { "compartment": "compartment_7660", "id": "reaction_10649817", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649810" ], "products": [ "species_10649814" ], "modifiers": [ [ "species_10649810", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10618987": { "compartment": "compartment_204883", "id": "reaction_10618987", "reactome": "R-CEL-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983" ], "products": [ "species_10618985" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10621121": { "compartment": "compartment_876", "id": "reaction_10621121", "reactome": "R-CEL-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973" ], "products": [ "species_10618983" ], "modifiers": [], "additional_components": [ "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10618981": { "compartment": "compartment_70101", "id": "reaction_10618981", "reactome": "R-CEL-419003", "name": "Interaction of Nectins with Afadin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973", "species_10618971" ], "products": [ "species_10618979" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00021009", "Q86NJ4", "WBGene00021009", "G5EG33", "WBGene00001863" ] }, "reaction_10619084": { "compartment": "compartment_20699", "id": "reaction_10619084", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617173" ], "products": [ "species_10619076", "species_10617114" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10617118": { "compartment": "compartment_70101", "id": "reaction_10617118", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617114" ], "products": [ "species_10617116" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10617166": { "compartment": "compartment_70101", "id": "reaction_10617166", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601197" ], "products": [ "species_29370", "species_10617163" ], "modifiers": [ [ "species_10617139", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10617156": { "compartment": "compartment_12045", "id": "reaction_10617156", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617148" ], "products": [ "species_29370", "species_10617153" ], "modifiers": [ [ "species_10617148", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10617158": { "compartment": "compartment_12045", "id": "reaction_10617158", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617146" ], "products": [ "species_10617148" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10628857": { "compartment": "compartment_70101", "id": "reaction_10628857", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628845" ], "products": [ "species_10628851" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10628923": { "compartment": "compartment_7660", "id": "reaction_10628923", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628851", "species_10628892" ], "products": [ "species_10628894" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00000095", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639875": { "compartment": "compartment_70101", "id": "reaction_10639875", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639873", "species_10639871" ], "products": [ "species_10639772" ], "modifiers": [], "additional_components": [ "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O16303", "WBGene00001037", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030" ] }, "reaction_10617141": { "compartment": "compartment_12045", "id": "reaction_10617141", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130" ], "products": [ "species_10617139" ], "modifiers": [], "additional_components": [ "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10628905": { "compartment": "compartment_7660", "id": "reaction_10628905", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10628894", "species_10628901", "species_29428" ], "products": [ "species_10628903" ], "modifiers": [], "additional_components": [ "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639777": { "compartment": "compartment_70101", "id": "reaction_10639777", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639772" ], "products": [ "species_10639774", "species_29372" ], "modifiers": [ [ "species_10639772", "catalyst" ], [ "species_10639770", "catalyst" ] ], "additional_components": [ "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_29370", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "O45502", "WBGene00001030" ] }, "reaction_10617181": { "compartment": "compartment_12045", "id": "reaction_10617181", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617177" ], "products": [ "species_10617171" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10665100": { "compartment": "compartment_876", "id": "reaction_10665100", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615353", "species_9634838" ], "products": [ "species_10615363" ], "modifiers": [], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10615850": { "compartment": "compartment_984", "id": "reaction_10615850", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660314": { "compartment": "compartment_13946", "id": "reaction_10660314", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660280" ], "products": [ "species_10659955", "species_10660290", "species_29420" ], "modifiers": [ [ "species_10660311", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9UAQ6", "WBGene00004266", "Q9BKQ5", "WBGene00022051", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29438", "Q5WRR4", "WBGene00016614", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "Q95QQ2", "WBGene00016964", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "O02173", "WBGene00021046" ] }, "reaction_10659968": { "compartment": "compartment_216813", "id": "reaction_10659968", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10659957" ], "products": [ "species_10659955", "species_10659961", "species_29420" ], "modifiers": [ [ "species_10659965", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q94986", "WBGene00004267", "Q20759", "WBGene00010045", "O02626", "WBGene00000086" ] }, "reaction_10660750": { "compartment": "compartment_70101", "id": "reaction_10660750", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660324", "species_113592" ], "products": [ "species_29370", "species_10660745" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10660061": { "compartment": "compartment_437051", "id": "reaction_10660061", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660045" ], "products": [ "species_10660049", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660054", "catalyst" ] ], "additional_components": [ "species_29420", "Q94148", "WBGene00004273", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10660203": { "compartment": "compartment_171062", "id": "reaction_10660203", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660192" ], "products": [ "species_10660196", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660198", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q22045", "WBGene00004279", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10660096": { "compartment": "compartment_263163", "id": "reaction_10660096", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660085" ], "products": [ "species_10659955", "species_10660093", "species_29420" ], "modifiers": [ [ "species_10657253", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10660170": { "compartment": "compartment_70101", "id": "reaction_10660170", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660154" ], "products": [ "species_10660158", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660167", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29438", "Q93874", "WBGene00004276", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10660377": { "compartment": "compartment_20699", "id": "reaction_10660377", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660361" ], "products": [ "species_10660367", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660372", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29438", "Q18969", "WBGene00004286", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10660123": { "compartment": "compartment_262783", "id": "reaction_10660123", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660114" ], "products": [ "species_10659955", "species_10660118", "species_29420" ], "modifiers": [ [ "species_10660120", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "U4PBM1", "WBGene00018681" ] }, "reaction_10660329": { "compartment": "compartment_262783", "id": "reaction_10660329", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660318", "species_29438" ], "products": [ "species_10660322", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660324", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10660406": { "compartment": "compartment_12045", "id": "reaction_10660406", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660393" ], "products": [ "species_10660397", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660403", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q8MXS1", "WBGene00004277", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10660150": { "compartment": "compartment_204883", "id": "reaction_10660150", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660141" ], "products": [ "species_10659955", "species_29420", "species_10660145" ], "modifiers": [ [ "species_10660147", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375" ] }, "reaction_10660245": { "compartment": "compartment_5668575", "id": "reaction_10660245", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660232" ], "products": [ "species_10660242", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10645717", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29438", "G5EBS5", "WBGene00000089", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10660272": { "compartment": "compartment_17938", "id": "reaction_10660272", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660249" ], "products": [ "species_10659955", "species_10660255", "species_29420" ], "modifiers": [ [ "species_10660269", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q23146", "WBGene00004271", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q23146", "WBGene00004271", "Q9BI89", "WBGene00018321", "Q9XVL8", "WBGene00010283" ] }, "reaction_10660081": { "compartment": "compartment_263163", "id": "reaction_10660081", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660065" ], "products": [ "species_10659955", "species_10660071", "species_29420" ], "modifiers": [ [ "species_10660078", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375", "Q20759", "WBGene00010045" ] }, "reaction_10660110": { "compartment": "compartment_70101", "id": "reaction_10660110", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660103", "species_113592" ], "products": [ "species_29370", "species_10660107" ], "modifiers": [ [ "species_10646852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10620770": { "compartment": "compartment_70101", "id": "reaction_10620770", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10620720", "species_10620753" ], "products": [ "species_10620768" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "WBGene00022048", "WBGene00006999", "U4PBJ9", "WBGene00022048", "species_113592", "P10984", "WBGene00000064", "Q9U3F4", "WBGene00006999" ] }, "reaction_10622043": { "compartment": "compartment_984", "id": "reaction_10622043", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445", "species_10622041" ], "products": [ "species_10621032" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10622187": { "compartment": "compartment_70101", "id": "reaction_10622187", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620753", "species_10622183" ], "products": [ "species_10622185" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621040": { "compartment": "compartment_984", "id": "reaction_10621040", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621036", "species_10621032" ], "products": [ "species_10621038" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10620762": { "compartment": "compartment_70101", "id": "reaction_10620762", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620758", "species_10620753" ], "products": [ "species_10620760" ], "modifiers": [], "additional_components": [ "WBGene00006836", "WBGene00006999", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621020": { "compartment": "compartment_70101", "id": "reaction_10621020", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612261", "species_10621016" ], "products": [ "species_10621018" ], "modifiers": [], "additional_components": [ "WBGene00003930", "WBGene00003931", "Q9TZC4", "WBGene00003931", "Q27874", "WBGene00003930" ] }, "reaction_10622206": { "compartment": "compartment_70101", "id": "reaction_10622206", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622200", "species_10621016", "species_10622198" ], "products": [ "species_10622204" ], "modifiers": [], "additional_components": [ "O16785", "WBGene00003932", "WBGene00003931", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "O16785", "WBGene00003932", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "Q9TZC4", "WBGene00003931" ] }, "reaction_10622039": { "compartment": "compartment_70101", "id": "reaction_10622039", "reactome": "R-CEL-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622035", "species_10621038" ], "products": [ "species_10622037" ], "modifiers": [], "additional_components": [ "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "P34285", "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10621024": { "compartment": "compartment_70101", "id": "reaction_10621024", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614419", "species_10611919" ], "products": [ "species_10621022" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10609990": { "compartment": "compartment_876", "id": "reaction_10609990", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609944", "species_10609939" ], "products": [ "species_10609988" ], "modifiers": [], "additional_components": [ "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10609992": { "compartment": "compartment_70101", "id": "reaction_10609992", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609988" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10603861": { "compartment": "compartment_7660", "id": "reaction_10603861", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10603858" ], "products": [ "species_113582", "species_10603854" ], "modifiers": [ [ "species_10603858", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605290": { "compartment": "compartment_7660", "id": "reaction_10605290", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603858" ], "products": [ "species_10603858" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10609645": { "compartment": "compartment_984", "id": "reaction_10609645", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609687": { "compartment": "compartment_984", "id": "reaction_10609687", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10609684", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10609670": { "compartment": "compartment_984", "id": "reaction_10609670", "reactome": "R-CEL-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10646409": { "compartment": "compartment_984", "id": "reaction_10646409", "reactome": "R-CEL-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609994": { "compartment": "compartment_984", "id": "reaction_10609994", "reactome": "R-CEL-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609690": { "compartment": "compartment_984", "id": "reaction_10609690", "reactome": "R-CEL-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10650244": { "compartment": "compartment_984", "id": "reaction_10650244", "reactome": "R-CEL-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786438", "species_109276" ], "products": [ "species_6786428", "species_6786426" ], "modifiers": [ [ "species_10650241", "catalyst" ] ], "additional_components": [ "species_1678743", "WBGene00021252" ] }, "reaction_10609998": { "compartment": "compartment_984", "id": "reaction_10609998", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189071", "species_109276" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609697": { "compartment": "compartment_984", "id": "reaction_10609697", "reactome": "R-CEL-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10610000": { "compartment": "compartment_984", "id": "reaction_10610000", "reactome": "R-CEL-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10609996": { "compartment": "compartment_984", "id": "reaction_10609996", "reactome": "R-CEL-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10648681": { "compartment": "compartment_7660", "id": "reaction_10648681", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648674" ], "products": [ "species_113582", "species_113550", "species_10648678" ], "modifiers": [ [ "species_10648674", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q95PZ4", "WBGene00013441", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648331": { "compartment": "compartment_7660", "id": "reaction_10648331", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648306", "species_10648325" ], "products": [ "species_10601816", "species_10648329" ], "modifiers": [], "additional_components": [ "WBGene00006963", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648692": { "compartment": "compartment_7660", "id": "reaction_10648692", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648689", "species_30555" ], "products": [ "species_10648685", "species_113541" ], "modifiers": [ [ "species_10648689", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10648687": { "compartment": "compartment_7660", "id": "reaction_10648687", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10648323" ], "products": [ "species_10648325" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10604545": { "compartment": "compartment_7660", "id": "reaction_10604545", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604541", "species_10604536" ], "products": [ "species_10604543" ], "modifiers": [], "additional_components": [ "WBGene00008140", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10637467": { "compartment": "compartment_876", "id": "reaction_10637467", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614508", "species_10637463" ], "products": [ "species_10637465" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10637471": { "compartment": "compartment_984", "id": "reaction_10637471", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10636719" ], "products": [ "species_10637469" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636627": { "compartment": "compartment_876", "id": "reaction_10636627", "reactome": "R-CEL-2396395", "name": "HSPG2 (perlecan) binds alpha-dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636623", "species_10631599" ], "products": [ "species_10636625" ], "modifiers": [], "additional_components": [ "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "WBGene00006787", "Q22629", "WBGene00000961", "Q06561", "WBGene00006787", "O61756", "WBGene00018943" ] }, "reaction_10636875": { "compartment": "compartment_984", "id": "reaction_10636875", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636871", "species_10636867" ], "products": [ "species_10636873" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "WBGene00002247", "Q10651", "WBGene00000149", "O44565", "WBGene00002247" ] }, "reaction_10649760": { "compartment": "compartment_7660", "id": "reaction_10649760", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649737", "species_10597874" ], "products": [ "species_10649757" ], "modifiers": [ [ "species_10649737", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10649741": { "compartment": "compartment_7660", "id": "reaction_10649741", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649724", "species_10649716" ], "products": [ "species_10649726" ], "modifiers": [], "additional_components": [ "WBGene00010011", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011" ] }, "reaction_10649787": { "compartment": "compartment_7660", "id": "reaction_10649787", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649778" ], "products": [ "species_10649784", "species_10597874" ], "modifiers": [ [ "species_10649778", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649714": { "compartment": "compartment_7660", "id": "reaction_10649714", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10601853", "species_10599971" ], "products": [ "species_10649712" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649719": { "compartment": "compartment_7660", "id": "reaction_10649719", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10649712" ], "products": [ "species_113541", "species_10649716" ], "modifiers": [ [ "species_10649712", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649739": { "compartment": "compartment_7660", "id": "reaction_10649739", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649735", "species_10649726" ], "products": [ "species_10648738", "species_10649737" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q18963", "WBGene00008403", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q23457", "WBGene00004320", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10637202": { "compartment": "compartment_984", "id": "reaction_10637202", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255" ], "products": [ "species_10612257" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636530": { "compartment": "compartment_876", "id": "reaction_10636530", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10612265" ], "products": [ "species_10636528" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10657257": { "compartment": "compartment_20699", "id": "reaction_10657257", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657247", "species_10657253" ], "products": [ "species_10657255" ], "modifiers": [], "additional_components": [ "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q7YWW8", "WBGene00010815", "Q20365", "WBGene00004283", "species_29438", "Q09417", "WBGene00011071" ] }, "reaction_10656786": { "compartment": "compartment_20699", "id": "reaction_10656786", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10656782" ], "products": [ "species_10656784" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q95XZ0", "WBGene00021784", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q6AW08", "WBGene00022121", "Q20797", "WBGene00006373", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305" ] }, "reaction_10657525": { "compartment": "compartment_20699", "id": "reaction_10657525", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10657521" ], "products": [ "species_10657523" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "P34213", "WBGene00004269", "species_29438", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "Q22782", "WBGene00004270", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "P34213", "WBGene00004269", "species_29438", "G5EE66", "WBGene00003258", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "O44502", "WBGene00019820", "Q22782", "WBGene00004270" ] }, "reaction_10657238": { "compartment": "compartment_20699", "id": "reaction_10657238", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657234" ], "products": [ "species_10657236" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10623845": { "compartment": "compartment_876", "id": "reaction_10623845", "reactome": "R-CEL-532603", "name": "Nephrin mediated activation of N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623841", "species_10612328" ], "products": [ "species_10623843" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9TXI8", "WBGene00018215", "Q95PX0", "WBGene00006410", "WBGene00007840", "G5EE56", "WBGene00005077", "Q9TXI8", "WBGene00018215", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410" ] }, "reaction_10615502": { "compartment": "compartment_876", "id": "reaction_10615502", "reactome": "R-CEL-373732", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615464" ], "products": [ "species_10615466" ], "modifiers": [], "additional_components": [ "WBGene00018215", "Q9TXI8", "WBGene00018215" ] }, "reaction_10636526": { "compartment": "compartment_984", "id": "reaction_10636526", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10631430" ], "products": [ "species_10636524" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] } }, "collapsed_reaction_dictionary": { "reaction_10605393": { "compartment": "compartment_17906", "id": "reaction_10605393", "reactome": "R-CEL-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605391" ], "products": [ "species_10605349" ], "modifiers": [], "additional_components": [ "Q23240", "WBGene00013854", "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "P19974", "WBGene00017121" ] }, "reaction_10605944": { "compartment": "compartment_13231", "id": "reaction_10605944", "reactome": "R-CEL-158441", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604072" ], "products": [ "species_10605942" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10604074": { "compartment": "compartment_7660", "id": "reaction_10604074", "reactome": "R-CEL-77594", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600236", "species_10604068", "species_10602784" ], "products": [ "species_10604072", "species_10600698", "species_10599886" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00000122", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003835", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10605948": { "compartment": "compartment_70101", "id": "reaction_10605948", "reactome": "R-CEL-158447", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605942", "species_10601226" ], "products": [ "species_10602837", "species_10602815", "species_10605946" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00002061", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10646047": { "compartment": "compartment_7660", "id": "reaction_10646047", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604739" ], "products": [ "species_10646044" ], "modifiers": [ [ "species_10604739", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604733": { "compartment": "compartment_7660", "id": "reaction_10604733", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10604730" ], "products": [ "species_10604726", "species_113541" ], "modifiers": [ [ "species_10604730", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604741": { "compartment": "compartment_7660", "id": "reaction_10604741", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604737", "species_10598275" ], "products": [ "species_10604739" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10639098": { "compartment": "compartment_70101", "id": "reaction_10639098", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639084" ], "products": [ "species_10639086" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639106": { "compartment": "compartment_70101", "id": "reaction_10639106", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639104", "species_113592" ], "products": [ "species_29370", "species_10639084" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639096": { "compartment": "compartment_70101", "id": "reaction_10639096", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639086" ], "products": [ "species_10639094" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10659999": { "compartment": "compartment_876", "id": "reaction_10659999", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10659994", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659992": { "compartment": "compartment_70101", "id": "reaction_10659992", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657701", "species_10617312" ], "products": [ "species_10659990" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659996": { "compartment": "compartment_70101", "id": "reaction_10659996", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10607816" ], "products": [ "species_10659994" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00021320", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660005": { "compartment": "compartment_70101", "id": "reaction_10660005", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10660001" ], "products": [ "species_10660003" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q20487", "WBGene00018520", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660008": { "compartment": "compartment_70101", "id": "reaction_10660008", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10660003", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10614891": { "compartment": "compartment_7660", "id": "reaction_10614891", "reactome": "R-CEL-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10614881" ], "products": [ "species_113582", "species_10614552" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00003917", "WBGene00000227" ] }, "reaction_10614556": { "compartment": "compartment_13231", "id": "reaction_10614556", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614552" ], "products": [ "species_10614554" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10614561": { "compartment": "compartment_70101", "id": "reaction_10614561", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614554", "species_10597908" ], "products": [ "species_10614558" ], "modifiers": [ [ "species_10614554", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00006727", "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00003917" ] }, "reaction_10598360": { "compartment": "compartment_7660", "id": "reaction_10598360", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598355", "species_10598298" ], "products": [ "species_10598357" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10609600": { "compartment": "compartment_7660", "id": "reaction_10609600", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_10598355" ], "products": [ "species_10609593" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517" ] }, "reaction_10614563": { "compartment": "compartment_70101", "id": "reaction_10614563", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614558" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10644160": { "compartment": "compartment_70101", "id": "reaction_10644160", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10644150": { "compartment": "compartment_984", "id": "reaction_10644150", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "CHEBI:78587", "CHEBI:78581", "CHEBI:78579", "CHEBI:78584", "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10644111": { "compartment": "compartment_70101", "id": "reaction_10644111", "reactome": "R-CEL-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605853": { "compartment": "compartment_70101", "id": "reaction_10605853", "reactome": "R-CEL-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10622150": { "compartment": "compartment_12045", "id": "reaction_10622150", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10622147", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10656532": { "compartment": "compartment_70101", "id": "reaction_10656532", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29356" ], "products": [ "species_109402", "species_29548" ], "modifiers": [ [ "species_10656529", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10625950": { "compartment": "compartment_70101", "id": "reaction_10625950", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10625945" ], "products": [ "species_10625947", "species_29370" ], "modifiers": [ [ "species_10625945", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", 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"WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625929": { "compartment": "compartment_70101", "id": "reaction_10625929", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625926" ], "products": [ "species_10625911" ], "modifiers": [ [ "species_10625926", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q93594", "WBGene00009141", "Q09543", "WBGene00003901", "Q9BL68", "WBGene00004884", "O01763", "WBGene00018156", "G5EGK8", "WBGene00002363", "A0A486WX07", "WBGene00002066", "G5EDR3", "WBGene00006352", "D0G912", "WBGene00194816", "O76512", "WBGene00004880", "Q9U302", "WBGene00003902", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10665669": { "compartment": "compartment_17947", "id": "reaction_10665669", "reactome": "R-CEL-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665661" ], "products": [ "species_10665667" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665338": { "compartment": "compartment_18667", "id": "reaction_10665338", "reactome": "R-CEL-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665330" ], "products": [ "species_10665336", "species_10616991", "species_10656088" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "Q22799", "WBGene00001005", "P30644", "WBGene00015264", "species_29420", "Q18817", "WBGene00000248", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q11083", "WBGene00015264", "G5ED34", "WBGene00001007", "H2L2E8", "WBGene00006528", "species_29438", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005" ] }, "reaction_10665685": { "compartment": "compartment_70101", "id": "reaction_10665685", "reactome": "R-CEL-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665651", "species_10642212" ], "products": [ "species_10665653" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "WBGene00015552", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10642254": { "compartment": "compartment_70101", "id": "reaction_10642254", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642201", "species_10642207", "species_10642195", "species_10642193", "species_10642212" ], "products": [ "species_10642214" ], "modifiers": [], "additional_components": [ "WBGene00008236", "WBGene00019900", "WBGene00001509", "WBGene00001509", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665641": { "compartment": "compartment_70101", "id": "reaction_10665641", "reactome": "R-CEL-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665637", "species_10664317" ], "products": [ "species_10665639" ], "modifiers": [], "additional_components": [ "WBGene00000227", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665679": { "compartment": "compartment_17947", "id": "reaction_10665679", "reactome": "R-CEL-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665675" ], "products": [ "species_10665677" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10665657": { "compartment": "compartment_17947", "id": "reaction_10665657", "reactome": "R-CEL-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665653" ], "products": [ "species_10665655" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10662842": { "compartment": "compartment_21994", "id": "reaction_10662842", "reactome": "R-CEL-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662838", "species_10642246" ], "products": [ "species_10662840" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q22252", "WBGene00011528", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q23536", "WBGene00002981", "Q10931", "WBGene00002982", "Q22252", "WBGene00011528" ] }, "reaction_10642225": { "compartment": "compartment_70101", "id": "reaction_10642225", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10642214" ], "products": [ "species_10642223" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q23536", "WBGene00002981", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665671": { "compartment": "compartment_17947", "id": "reaction_10665671", "reactome": "R-CEL-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665643", "species_10665659" ], "products": [ "species_10665661" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "WBGene00000227", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10662844": { "compartment": "compartment_70101", "id": "reaction_10662844", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10661490" ], "products": [ "species_10662838" ], "modifiers": [], "additional_components": [ "WBGene00002981", "WBGene00011528", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10661493": { "compartment": "compartment_17906", "id": "reaction_10661493", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661490" ], "modifiers": [ [ "species_10661471", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10665228": { "compartment": "compartment_70101", "id": "reaction_10665228", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665220", "species_10665224" ], "products": [ "species_10665226" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642252": { "compartment": "compartment_17906", "id": "reaction_10642252", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642230" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665284": { "compartment": "compartment_70101", "id": "reaction_10665284", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665226" ], "products": [ "species_10665282" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10661481": { "compartment": "compartment_70101", "id": "reaction_10661481", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661463" ], "products": [ "species_10661460" ], "modifiers": [ [ "species_10661478", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10661465": { "compartment": "compartment_70101", "id": "reaction_10661465", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661463" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665286": { "compartment": "compartment_70101", "id": "reaction_10665286", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665282" ], "products": [ "species_10665256" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "O45495", "WBGene00006730", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642258": { "compartment": "compartment_17927", "id": "reaction_10642258", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642256" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665683": { "compartment": "compartment_17947", "id": "reaction_10665683", "reactome": "R-CEL-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665667" ], "products": [ "species_10665651" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661487": { "compartment": "compartment_70101", "id": "reaction_10661487", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661463" ], "products": [ "species_29370", "species_10661484" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00005077" ] }, "reaction_10665320": { "compartment": "compartment_70101", "id": "reaction_10665320", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665316", "species_10656088" ], "products": [ "species_10665318" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "O45087", "WBGene00015927", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "G5ED34", "WBGene00001007", "Q22799", "WBGene00001005", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885" ] }, "reaction_10665681": { "compartment": "compartment_70101", "id": "reaction_10665681", "reactome": "R-CEL-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665639" ], "products": [ "species_10665659" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661473": { "compartment": "compartment_17906", "id": "reaction_10661473", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646604" ], "products": [ "species_10661471" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10624305": { "compartment": "compartment_876", "id": "reaction_10624305", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10624302", "catalyst" ] ], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10624483": { "compartment": "compartment_984", "id": "reaction_10624483", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624300", "species_372533" ], "products": [ "species_10624302" ], "modifiers": [], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "Q93323", "WBGene00007903", "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10656521": { "compartment": "compartment_172574", "id": "reaction_10656521", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656517" ], "products": [ "species_10656519" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10656524": { "compartment": "compartment_7660", "id": "reaction_10656524", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_113550", "species_6810408" ], "modifiers": [ [ "species_10656519", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10656818": { "compartment": "compartment_7660", "id": "reaction_10656818", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10656815", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10611022": { "compartment": "compartment_7660", "id": "reaction_10611022", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10607257", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664813": { "compartment": "compartment_70101", "id": "reaction_10664813", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607886" ], "products": [ "species_10611039" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664806": { "compartment": "compartment_70101", "id": "reaction_10664806", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664792", "species_113592" ], "products": [ "species_29370", "species_10664801" ], "modifiers": [ [ "species_10664792", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10664790": { "compartment": "compartment_74700", "id": "reaction_10664790", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10664786", "species_10647064" ], "products": [ "species_10664788" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10612228": { "compartment": "compartment_876", "id": "reaction_10612228", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10605404" ], "products": [ "species_10612226" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10664854": { "compartment": "compartment_7660", "id": "reaction_10664854", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664849", "species_29358" ], "products": [ "species_113582", "species_10664852" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10611305": { "compartment": "compartment_7660", "id": "reaction_10611305", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611302", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10664811": { "compartment": "compartment_74700", "id": "reaction_10664811", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664808" ], "products": [ "species_29370", "species_10664786" ], "modifiers": [ [ "species_10664808", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10611033": { "compartment": "compartment_7660", "id": "reaction_10611033", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611029" ], "products": [ "species_10611031" ], "modifiers": [], "additional_components": [ "WBGene00004859", "WBGene00004859" ] }, "reaction_10611296": { "compartment": "compartment_7660", "id": "reaction_10611296", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611290" ], "products": [ "species_113582", "species_10611293" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10611307": { "compartment": "compartment_7660", "id": "reaction_10611307", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10664803": { "compartment": "compartment_70101", "id": "reaction_10664803", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664801" ], "products": [ "species_10618752", "species_10647089", "species_10664786" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10664844": { "compartment": "compartment_7660", "id": "reaction_10664844", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10607457": { "compartment": "compartment_876", "id": "reaction_10607457", "reactome": "R-CEL-169904", "name": "C3G stimulates nucleotide exchange on Rap1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607452" ], "products": [ "species_10607454", "species_29420" ], "modifiers": [ [ "species_10607443", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10612373": { "compartment": "compartment_7660", "id": "reaction_10612373", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10612370", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10607466": { "compartment": "compartment_876", "id": "reaction_10607466", "reactome": "R-CEL-169905", "name": "ARMS is phosphorylated by active TrkA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607463" ], "products": [ "species_29370", "species_10607443" ], "modifiers": [ [ "species_10607463", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10607846": { "compartment": "compartment_876", "id": "reaction_10607846", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10607842" ], "products": [ "species_10607844" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017891", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10647187": { "compartment": "compartment_70101", "id": "reaction_10647187", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618752" ], "products": [ "species_10607886" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10607820": { "compartment": "compartment_74700", "id": "reaction_10607820", "reactome": "R-CEL-170978", "name": "p-FRS2:CRKL binds C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607816", "species_10607811" ], "products": [ "species_10607818" ], "modifiers": [], "additional_components": [ "WBGene00021320", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "E6N0V1", "WBGene00018819", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "H2KZX7", "WBGene00021320", "E6N0V1", "WBGene00018819" ] }, "reaction_10664799": { "compartment": "compartment_74700", "id": "reaction_10664799", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664788", "species_113592" ], "products": [ "species_10664792", "species_29370" ], "modifiers": [ [ "species_10664788", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10609591": { "compartment": "compartment_70101", "id": "reaction_10609591", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609556" ], "products": [ "species_29370", "species_10609574" ], "modifiers": [ [ "species_10609588", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496" ] }, "reaction_10611336": { "compartment": "compartment_7660", "id": "reaction_10611336", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10611333", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "A9UJN4", "WBGene00007554", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10607445": { "compartment": "compartment_984", "id": "reaction_10607445", "reactome": "R-CEL-169895", "name": "Crk's SH3 domain engages C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607443" ], "products": [ "species_10607443" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10611042": { "compartment": "compartment_7660", "id": "reaction_10611042", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10611039", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664875": { "compartment": "compartment_7660", "id": "reaction_10664875", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640193", "species_10664859", "species_10664871" ], "products": [ "species_10664873" ], "modifiers": [], "additional_components": [ "WBGene00002637", "WBGene00003107", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "U4PBA8", "WBGene00043705", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22002", "WBGene00003107", "U4PBA8", "WBGene00043705" ] }, "reaction_10637627": { "compartment": "compartment_876", "id": "reaction_10637627", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10614487" ], "products": [ "species_10637625" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10637623": { "compartment": "compartment_876", "id": "reaction_10637623", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10637619" ], "products": [ "species_10637621" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "P50605", "WBGene00004749" ] }, "reaction_10637924": { "compartment": "compartment_876", "id": "reaction_10637924", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637920", "species_10618504" ], "products": [ "species_10637922" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10637535": { "compartment": "compartment_876", "id": "reaction_10637535", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10609836" ], "products": [ "species_10637533" ], "modifiers": [], "additional_components": [ "WBGene00004749", "WBGene00002881", "Q11184", "WBGene00002881", "P50605", "WBGene00004749" ] }, "reaction_10638478": { "compartment": "compartment_70101", "id": "reaction_10638478", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638466", "species_3134861" ], "products": [ "species_10638468" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10638476": { "compartment": "compartment_70101", "id": "reaction_10638476", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638470", "species_3134861" ], "products": [ "species_10638472" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10622778": { "compartment": "compartment_876", "id": "reaction_10622778", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622774", "species_210382" ], "products": [ "species_10622776" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006", "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10622781": { "compartment": "compartment_70101", "id": "reaction_10622781", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10622776", "catalyst" ] ], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10598836": { "compartment": "compartment_70101", "id": "reaction_10598836", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10598833", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10598710": { "compartment": "compartment_5460", "id": "reaction_10598710", "reactome": "R-CEL-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10598707", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "WBGene00004259" ] }, "reaction_10622848": { "compartment": "compartment_5460", "id": "reaction_10622848", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10622845", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10598720": { "compartment": "compartment_70101", "id": "reaction_10598720", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10598717", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10607315": { "compartment": "compartment_7660", "id": "reaction_10607315", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607308" ], "products": [ "species_113582", "species_10607312" ], "modifiers": [ [ "species_10607290", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10607375": { "compartment": "compartment_7660", "id": "reaction_10607375", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_10607312" ], "products": [ "species_10607373" ], "modifiers": [], "additional_components": [ "WBGene00000223", "WBGene00012005", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10622474": { "compartment": "compartment_70101", "id": "reaction_10622474", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622458" ], "products": [ "species_10622472" ], "modifiers": [], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607371": { "compartment": "compartment_70101", "id": "reaction_10607371", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607329" ], "products": [ "species_29370", "species_10607343" ], "modifiers": [ [ "species_10607368", "catalyst" ] ], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "O01706", "WBGene00012162", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10622491": { "compartment": "compartment_7660", "id": "reaction_10622491", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622488" ], "products": [ "species_113582", "species_10622403" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607303": { "compartment": "compartment_7660", "id": "reaction_10607303", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607226" ], "products": [ "species_113582", "species_10607230" ], "modifiers": [ [ "species_10607300", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "P39745", "WBGene00003401", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "Q17446", "WBGene00004055", "U4PDY6", "WBGene00019665" ] }, "reaction_10622517": { "compartment": "compartment_70101", "id": "reaction_10622517", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343" ], "products": [ "species_10607290" ], "modifiers": [], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10622418": { "compartment": "compartment_7660", "id": "reaction_10622418", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622403" ], "products": [ "species_113582", "species_10622415" ], "modifiers": [ [ "species_10622403", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10622422": { "compartment": "compartment_70101", "id": "reaction_10622422", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622415" ], "products": [ "species_10622420" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10628646": { "compartment": "compartment_70101", "id": "reaction_10628646", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628641" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628643" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00022048", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "U4PBJ9", "WBGene00022048", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10625395": { "compartment": "compartment_13231", "id": "reaction_10625395", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625381" ], "products": [ "species_10625389", "species_10625393", "species_10625391" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00002075", "WBGene00009956" ] }, "reaction_10628669": { "compartment": "compartment_70101", "id": "reaction_10628669", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628665" ], "products": [ "species_10627823", "species_10628632", "species_10628667", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10663507": { "compartment": "compartment_70101", "id": "reaction_10663507", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8983696", "species_29356" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10663504", "catalyst" ] ], "additional_components": [ "species_113592", "WBGene00011268" ] }, "reaction_10633391": { "compartment": "compartment_70101", "id": "reaction_10633391", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628679" ], "products": [ "species_141681", "species_10628677" ], "modifiers": [ [ "species_10633388", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "Q22240", "WBGene00011507" ] }, "reaction_10633412": { "compartment": "compartment_70101", "id": "reaction_10633412", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633398", "species_10633408" ], "products": [ "species_10633410", "species_10633406" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10666093": { "compartment": "compartment_70101", "id": "reaction_10666093", "reactome": "R-CEL-9710963", "name": "p-STAT1dimer:KPNA1 binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666087", "species_10614210" ], "products": [ "species_10666091" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "WBGene00002075", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628681": { "compartment": "compartment_70101", "id": "reaction_10628681", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628677", "species_10628634", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628679" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006713", "WBGene00016158", "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10666089": { "compartment": "compartment_70101", "id": "reaction_10666089", "reactome": "R-CEL-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614205", "species_10625312" ], "products": [ "species_10666087" ], "modifiers": [], "additional_components": [ "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628650": { "compartment": "compartment_70101", "id": "reaction_10628650", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_10627458" ], "products": [ "species_10628648" ], "modifiers": [], "additional_components": [ "WBGene00018660", "WBGene00022358", "O44820", "WBGene00018660", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10633414": { "compartment": "compartment_70101", "id": "reaction_10633414", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10633396" ], "products": [ "species_10633398" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00002062", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158" ] }, "reaction_10625031": { "compartment": "compartment_13231", "id": "reaction_10625031", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625021" ], "products": [ "species_10625029" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628639": { "compartment": "compartment_70101", "id": "reaction_10628639", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_113592", "species_10627828" ], "products": [ "species_111294", "species_10628636", "species_76577" ], "modifiers": [ [ "species_10627828", "catalyst" ] ], "additional_components": [ "WBGene00018660", "WBGene00006699", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "WBGene00006699" ] }, "reaction_10628659": { "compartment": "compartment_70101", "id": "reaction_10628659", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627823", "species_10628636" ], "products": [ "species_10628627", "species_10627828" ], "modifiers": [ [ "species_10627823", "catalyst" ] ], "additional_components": [ "WBGene00006713", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "WBGene00006699", "WBGene00006713" ] }, "reaction_10628654": { "compartment": "compartment_70101", "id": "reaction_10628654", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10612207", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_10628652", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006708", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "Q95XX0", "WBGene00006708", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10628656": { "compartment": "compartment_70101", "id": "reaction_10628656", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628632", "species_10628627" ], "products": [ "species_10628634" ], "modifiers": [], "additional_components": [ "WBGene00016158", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10657691": { "compartment": "compartment_17963", "id": "reaction_10657691", "reactome": "R-CEL-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657686" ], "products": [ "species_10609860" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00002881" ] }, "reaction_10646301": { "compartment": "compartment_70101", "id": "reaction_10646301", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636505", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646280": { "compartment": "compartment_70101", "id": "reaction_10646280", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646277", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646291": { "compartment": "compartment_70101", "id": "reaction_10646291", "reactome": "R-CEL-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608561", "species_10636509" ], "products": [ "species_10636511" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646246": { "compartment": "compartment_984", "id": "reaction_10646246", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646242", "species_190915" ], "products": [ "species_10646244" ], "modifiers": [], "additional_components": [ "WBGene00002181", "G5EDX1", "WBGene00002181", "species_190915" ] }, "reaction_10646181": { "compartment": "compartment_70101", "id": "reaction_10646181", "reactome": "R-CEL-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646176", "species_113592" ], "products": [ "species_10646178", "species_29370" ], "modifiers": [ [ "species_10646176", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646260": { "compartment": "compartment_876", "id": "reaction_10646260", "reactome": "R-CEL-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10636501" ], "modifiers": [ [ "species_10646248", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646204": { "compartment": "compartment_70101", "id": "reaction_10646204", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646201", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646197": { "compartment": "compartment_70101", "id": "reaction_10646197", "reactome": "R-CEL-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646194", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646267": { "compartment": "compartment_70101", "id": "reaction_10646267", "reactome": "R-CEL-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646192" ], "products": [ "species_10646194" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646298": { "compartment": "compartment_70101", "id": "reaction_10646298", "reactome": "R-CEL-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646289" ], "products": [ "species_10646293" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646265": { "compartment": "compartment_876", "id": "reaction_10646265", "reactome": "R-CEL-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646262" ], "products": [ "species_29370", "species_10646190" ], "modifiers": [ [ "species_10646262", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10657689": { "compartment": "compartment_17963", "id": "reaction_10657689", "reactome": "R-CEL-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10657684" ], "products": [ "species_205687", "species_10657686" ], "modifiers": [ [ "species_10625450", "catalyst" ] ], "additional_components": [ "WBGene00002881", "WBGene00002881", "P34678", "WBGene00001628", "O61394", "WBGene00001631" ] }, "reaction_10608563": { "compartment": "compartment_70101", "id": "reaction_10608563", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10608459" ], "products": [ "species_10608561" ], "modifiers": [], "additional_components": [ "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646269": { "compartment": "compartment_70101", "id": "reaction_10646269", "reactome": "R-CEL-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636501", "species_10608561" ], "products": [ "species_10636503" ], "modifiers": [], "additional_components": [ "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646253": { "compartment": "compartment_70101", "id": "reaction_10646253", "reactome": "R-CEL-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10646250" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10646174": { "compartment": "compartment_70101", "id": "reaction_10646174", "reactome": "R-CEL-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646169" ], "products": [ "species_29370", "species_10646171" ], "modifiers": [ [ "species_10646169", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646255": { "compartment": "compartment_70101", "id": "reaction_10646255", "reactome": "R-CEL-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10646221" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10655619": { "compartment": "compartment_7660", "id": "reaction_10655619", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599987", "species_10655615", "species_10600001" ], "products": [ "species_10655617" ], "modifiers": [], "additional_components": [ "WBGene00004207", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q4W5P0", "WBGene00022235", "P34541", "WBGene00019881", "Q9U3I0", "WBGene00009078", "Q18999", "WBGene00004207", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q4W5P0", "WBGene00022235", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "P34541", "WBGene00019881", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10646223": { "compartment": "compartment_876", "id": "reaction_10646223", "reactome": "R-CEL-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10636509" ], "modifiers": [ [ "species_10646208", "catalyst" ], [ "species_10646221", "inhibitor" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646287": { "compartment": "compartment_876", "id": "reaction_10646287", "reactome": "R-CEL-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646282" ], "products": [ "species_29370", "species_10646284" ], "modifiers": [ [ "species_10646282", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646296": { "compartment": "compartment_70101", "id": "reaction_10646296", "reactome": "R-CEL-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646293", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646237": { "compartment": "compartment_876", "id": "reaction_10646237", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646233", "species_10646231", "species_190915" ], "products": [ "species_10646235" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881", "Q95XJ7", "WBGene00022418", "Q95XJ7", "WBGene00022418", "species_190915", "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881" ] }, "reaction_10646304": { "compartment": "compartment_70101", "id": "reaction_10646304", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636513", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10638456": { "compartment": "compartment_70101", "id": "reaction_10638456", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638454" ], "products": [ "species_10638452" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10632792": { "compartment": "compartment_70101", "id": "reaction_10632792", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10632789", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10632759": { "compartment": "compartment_70101", "id": "reaction_10632759", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10664432": { "compartment": "compartment_5460", "id": "reaction_10664432", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664428" ], "products": [ "species_10639552", "species_1655881", "species_10663602" ], "modifiers": [], "additional_components": [ "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307", "WBGene00007099", "WBGene00011307" ] }, "reaction_10663852": { "compartment": "compartment_5460", "id": "reaction_10663852", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10632779": { "compartment": "compartment_70101", "id": "reaction_10632779", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632742": { "compartment": "compartment_70616", "id": "reaction_10632742", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10664426": { "compartment": "compartment_5460", "id": "reaction_10664426", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663602", "species_9012592" ], "products": [ "species_10664424", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307", "WBGene00011307", "WBGene00011307" ] }, "reaction_10632740": { "compartment": "compartment_5460", "id": "reaction_10632740", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10632737", "catalyst" ] ], "additional_components": [ "species_947539", "Q9XTQ8", "WBGene00010397" ] }, "reaction_10663887": { "compartment": "compartment_5460", "id": "reaction_10663887", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10664430": { "compartment": "compartment_5460", "id": "reaction_10664430", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664424", "species_10639549" ], "products": [ "species_10664428" ], "modifiers": [], "additional_components": [ "WBGene00011307", "WBGene00007099", "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307" ] }, "reaction_10632782": { "compartment": "compartment_70101", "id": "reaction_10632782", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632777": { "compartment": "compartment_70616", "id": "reaction_10632777", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10632765", "species_113521" ], "products": [ "species_10632767", "species_1614538", "species_113529" ], "modifiers": [ [ "species_10632774", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "species_216667", "O17636", "WBGene00007886" ] }, "reaction_10632753": { "compartment": "compartment_70101", "id": "reaction_10632753", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10663605": { "compartment": "compartment_5460", "id": "reaction_10663605", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10656962": { "compartment": "compartment_70101", "id": "reaction_10656962", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10656959", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10663885": { "compartment": "compartment_5460", "id": "reaction_10663885", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10657228": { "compartment": "compartment_12045", "id": "reaction_10657228", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10657225", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398", "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399" ] }, "reaction_10623933": { "compartment": "compartment_70101", "id": "reaction_10623933", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10623928", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10648592": { "compartment": "compartment_161320", "id": "reaction_10648592", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10648589", "catalyst" ] ], "additional_components": [ "species_6785219", "species_390435", "WBGene00004092" ] }, "reaction_10623940": { "compartment": "compartment_70101", "id": "reaction_10623940", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_29768", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_548819" ], "modifiers": [ [ "species_10623937", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10602893": { "compartment": "compartment_70101", "id": "reaction_10602893", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10602885", "catalyst" ], [ "species_10602891", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10611701": { "compartment": "compartment_70101", "id": "reaction_10611701", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10611698", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "O44560", "WBGene00020343", "A0A4V0ING4", "WBGene00016716", "V6CLI5", "WBGene00022037", "O16775", "WBGene00019920", "Q21872", "WBGene00011173" ] }, "reaction_10602965": { "compartment": "compartment_70101", "id": "reaction_10602965", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10602962", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10647332": { "compartment": "compartment_12045", "id": "reaction_10647332", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10647329", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517", "Q21905", "WBGene00011205" ] }, "reaction_10623876": { "compartment": "compartment_70101", "id": "reaction_10623876", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10623920": { "compartment": "compartment_70101", "id": "reaction_10623920", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10623917", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20904", "WBGene00001245", "Q20300", "WBGene00001243", "Q03574", "WBGene00001242", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241" ] }, "reaction_10611571": { "compartment": "compartment_70101", "id": "reaction_10611571", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602921", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10623923": { "compartment": "compartment_70101", "id": "reaction_10623923", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10610418", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10606634": { "compartment": "compartment_70101", "id": "reaction_10606634", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602960" ], "products": [ "species_10602962" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10648602": { "compartment": "compartment_12045", "id": "reaction_10648602", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10648599", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10602902": { "compartment": "compartment_70101", "id": "reaction_10602902", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10664094": { "compartment": "compartment_70101", "id": "reaction_10664094", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9023653" ], "products": [ "species_9023651", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664092": { "compartment": "compartment_70101", "id": "reaction_10664092", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10662619": { "compartment": "compartment_17947", "id": "reaction_10662619", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662607" ], "products": [ "species_10662616", "species_10628859" ], "modifiers": [ [ "species_10662607", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10660992": { "compartment": "compartment_70101", "id": "reaction_10660992", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660981", "species_10660979" ], "products": [ "species_10612207", "species_10660989", "species_10660972" ], "modifiers": [ [ "species_10660981", "catalyst" ] ], "additional_components": [ "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10660994": { "compartment": "compartment_70101", "id": "reaction_10660994", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660979", "species_10660972", "species_10660974" ], "products": [ "species_10660981" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10662609": { "compartment": "compartment_17947", "id": "reaction_10662609", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662605", "species_10662601" ], "products": [ "species_10662607" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10643471": { "compartment": "compartment_12045", "id": "reaction_10643471", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10643464" ], "products": [ "species_10643468" ], "modifiers": [ [ "species_10643464", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667" ] }, "reaction_10645821": { "compartment": "compartment_261122", "id": "reaction_10645821", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645817" ], "products": [ "species_10645819" ], "modifiers": [], "additional_components": [ "WBGene00004210", "WBGene00004210" ] }, "reaction_10644533": { "compartment": "compartment_876", "id": "reaction_10644533", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10644526", "catalyst" ], [ "species_10644531", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645932": { "compartment": "compartment_7660", "id": "reaction_10645932", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645929", "species_10597874" ], "products": [ "species_10645923" ], "modifiers": [ [ "species_10645929", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320" ] }, "reaction_10644620": { "compartment": "compartment_70101", "id": "reaction_10644620", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627451", "species_10621559" ], "products": [ "species_10644618" ], "modifiers": [], "additional_components": [ "WBGene00007009", "WBGene00003830", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10644632": { "compartment": "compartment_5263232", "id": "reaction_10644632", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10644628" ], "products": [ "species_10644622", "species_10644630" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10644522": { "compartment": "compartment_18730", "id": "reaction_10644522", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644487", "species_10644518" ], "products": [ "species_10644520" ], "modifiers": [], "additional_components": [ "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645925": { "compartment": "compartment_7660", "id": "reaction_10645925", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645923" ], "products": [ "species_10645921", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10608347": { "compartment": "compartment_70101", "id": "reaction_10608347", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176667" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10629186": { "compartment": "compartment_70101", "id": "reaction_10629186", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10629183", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10608127": { "compartment": "compartment_70101", "id": "reaction_10608127", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10608120" ], "products": [ "species_10608124", "species_174390" ], "modifiers": [ [ "species_10608120", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10608162": { "compartment": "compartment_70101", "id": "reaction_10608162", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10608159", "catalyst" ] ], "additional_components": [ "P27604", "WBGene00019322", "species_29360" ] }, "reaction_10662568": { "compartment": "compartment_17963", "id": "reaction_10662568", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10662565", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "Q5ZEQ3", "WBGene00012390", "species_109496" ] }, "reaction_10606293": { "compartment": "compartment_70101", "id": "reaction_10606293", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158858" ], "products": [ "species_158850", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608369": { "compartment": "compartment_70101", "id": "reaction_10608369", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176575" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608104": { "compartment": "compartment_12045", "id": "reaction_10608104", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10608101", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10608191": { "compartment": "compartment_70101", "id": "reaction_10608191", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_175973" ], "products": [ "species_71285", "species_175979" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10661289": { "compartment": "compartment_876", "id": "reaction_10661289", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247892", "species_109276" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10598417": { "compartment": "compartment_70101", "id": "reaction_10598417", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10598414", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10606403": { "compartment": "compartment_5460", "id": "reaction_10606403", "reactome": "R-CEL-159574", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159557", "species_159549" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10608094": { "compartment": "compartment_70101", "id": "reaction_10608094", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_29404" ], "products": [ "species_29370", "species_174393", "species_29372" ], "modifiers": [ [ "species_10608091", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10608137": { "compartment": "compartment_70101", "id": "reaction_10608137", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174370", "species_113592" ], "products": [ "species_158471", "species_29370" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10608340": { "compartment": "compartment_70101", "id": "reaction_10608340", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608374": { "compartment": "compartment_70101", "id": "reaction_10608374", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10608371", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606330": { "compartment": "compartment_70101", "id": "reaction_10606330", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10624752": { "compartment": "compartment_20699", "id": "reaction_10624752", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10624749", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10619928": { "compartment": "compartment_876", "id": "reaction_10619928", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10619925", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10654763": { "compartment": "compartment_70101", "id": "reaction_10654763", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10608355": { "compartment": "compartment_70101", "id": "reaction_10608355", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10608352", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10629176": { "compartment": "compartment_70101", "id": "reaction_10629176", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10608366": { "compartment": "compartment_70101", "id": "reaction_10608366", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_5695950" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10608363", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606401": { "compartment": "compartment_5460", "id": "reaction_10606401", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10639385": { "compartment": "compartment_5460", "id": "reaction_10639385", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3301954", "species_1655887" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10639382", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10608140": { "compartment": "compartment_70101", "id": "reaction_10608140", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174375", "species_113592" ], "products": [ "species_174370", "species_111294" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10629196": { "compartment": "compartment_70101", "id": "reaction_10629196", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10629193", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10649482": { "compartment": "compartment_70101", "id": "reaction_10649482", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_5696224", "species_29356", "species_111745" ], "modifiers": [ [ "species_10608209", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10608345": { "compartment": "compartment_70101", "id": "reaction_10608345", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176619" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10607919": { "compartment": "compartment_70101", "id": "reaction_10607919", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_158601" ], "modifiers": [ [ "species_10607916", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10608150": { "compartment": "compartment_70101", "id": "reaction_10608150", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10608147", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q21549", "WBGene00010941", "species_109496" ] }, "reaction_10605958": { "compartment": "compartment_70101", "id": "reaction_10605958", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158469" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606295": { "compartment": "compartment_70101", "id": "reaction_10606295", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158847" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608357": { "compartment": "compartment_70101", "id": "reaction_10608357", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608343": { "compartment": "compartment_70101", "id": "reaction_10608343", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_193103" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608256": { "compartment": "compartment_70101", "id": "reaction_10608256", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10608253", "catalyst" ] ], "additional_components": [ "species_76396", "species_3301954", "CHEBI:30614", "CHEBI:34479", "species_9753685", "species_3301969", "O45352", "WBGene00001792", "O45010", "WBGene00021127", "P34345", "WBGene00016204", "Q09596", "WBGene00001753", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337", "Q18938", "WBGene00001790", "P10299", "WBGene00001749" ] }, "reaction_10648957": { "compartment": "compartment_17957", "id": "reaction_10648957", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10648954", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10606424": { "compartment": "compartment_20699", "id": "reaction_10606424", "reactome": "R-CEL-159728", "name": "Furin cleaves pro-prothrombin to prothrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606405" ], "products": [ "species_10606409", "species_10606407" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "WBGene00008879", "WBGene00008879", "WBGene00008879", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10650363": { "compartment": "compartment_12045", "id": "reaction_10650363", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10650360", "catalyst" ] ], "additional_components": [ "species_216667", "P91402", "WBGene00019710" ] }, "reaction_10643368": { "compartment": "compartment_70101", "id": "reaction_10643368", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643348", "species_71284" ], "products": [ "species_353106", "species_10643335" ], "modifiers": [ [ "species_10643365", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "Q09454", "WBGene00007488", "P49958", "WBGene00007576", "Q21102", "WBGene00010484" ] }, "reaction_10606692": { "compartment": "compartment_20699", "id": "reaction_10606692", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606676" ], "products": [ "species_10606684", "species_10606690" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10643346": { "compartment": "compartment_70101", "id": "reaction_10643346", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643335", "species_71284" ], "products": [ "species_10643338", "species_71285" ], "modifiers": [ [ "species_10643343", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10650384": { "compartment": "compartment_70101", "id": "reaction_10650384", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_29370", "species_6788858" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10606430": { "compartment": "compartment_13959", "id": "reaction_10606430", "reactome": "R-CEL-159843", "name": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606428" ], "products": [ "species_10606405" ], "modifiers": [], "additional_components": [ "WBGene00008879", "WBGene00008879" ] }, "reaction_10613073": { "compartment": "compartment_70101", "id": "reaction_10613073", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_204628" ], "products": [ "species_29360", "species_204635", "species_10613063" ], "modifiers": [ [ "species_10613070", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10606678": { "compartment": "compartment_13959", "id": "reaction_10606678", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670" ], "products": [ "species_10606676" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10650386": { "compartment": "compartment_70101", "id": "reaction_10650386", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788868", "species_113592" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:24103", "CHEBI:87176", "CHEBI:87177", "CHEBI:87178", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10643332": { "compartment": "compartment_70101", "id": "reaction_10643332", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643324", "species_113592", "species_31633" ], "products": [ "species_10605934", "species_111294", "species_76577" ], "modifiers": [ [ "species_10643329", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10613101": { "compartment": "compartment_70101", "id": "reaction_10613101", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10613091" ], "modifiers": [ [ "species_10613098", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "species_113531", "Q17949", "WBGene00007555" ] }, "reaction_10648553": { "compartment": "compartment_7660", "id": "reaction_10648553", "reactome": "R-CEL-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10648537" ], "products": [ "species_10648551" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "Q95PZ4", "WBGene00013441", "P53016", "WBGene00004340", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "P34429", "WBGene00018409", "Q93456", "WBGene00008665", "Q19366", "WBGene00008722", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648672": { "compartment": "compartment_7660", "id": "reaction_10648672", "reactome": "R-CEL-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648669" ], "products": [ "species_10648537" ], "modifiers": [ [ "species_10648669", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320" ] }, "reaction_10663517": { "compartment": "compartment_876", "id": "reaction_10663517", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_10636623" ], "products": [ "species_10663515" ], "modifiers": [], "additional_components": [ "WBGene00004854", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "G5EFX6", "WBGene00004854" ] }, "reaction_10657351": { "compartment": "compartment_20699", "id": "reaction_10657351", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10657483": { "compartment": "compartment_12045", "id": "reaction_10657483", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657445", "species_113592" ], "products": [ "species_29370", "species_10657463", "species_10656090", "species_10657432" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10657481", "catalyst" ] ], "additional_components": [ "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "V6CJ04", "WBGene00016611", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10657547": { "compartment": "compartment_12045", "id": "reaction_10657547", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657543", "species_10657475" ], "products": [ "species_10657545" ], "modifiers": [], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656574": { "compartment": "compartment_20699", "id": "reaction_10656574", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656558", "species_10655931", "species_10656284", "species_10656560", "species_10656570" ], "products": [ "species_10656572" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "WBGene00018853", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "P90904", "WBGene00010500", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195" ] }, "reaction_10656616": { "compartment": "compartment_12045", "id": "reaction_10656616", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656614" ], "products": [ "species_10656607" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657436": { "compartment": "compartment_20699", "id": "reaction_10657436", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657419", "species_10657417", "species_10657432" ], "products": [ "species_10657434" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10656702": { "compartment": "compartment_12045", "id": "reaction_10656702", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656700" ], "products": [ "species_10649098", "species_10656652", "species_10656614", "species_10655913", "species_10656698" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q9N598", "WBGene00022460", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "Q19642", "WBGene00017643", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P90841", "WBGene00008990", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "species_29420", "Q9UAQ6", "WBGene00004266", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195" ] }, "reaction_10657447": { "compartment": "compartment_20699", "id": "reaction_10657447", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657434", "species_10657443" ], "products": [ "species_10657445", "species_10657441" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9NDC9", "WBGene00003047", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "WBGene00003047" ] }, "reaction_10656554": { "compartment": "compartment_20699", "id": "reaction_10656554", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656258", "species_10655846" ], "products": [ "species_10656552" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438" ] }, "reaction_10656610": { "compartment": "compartment_12045", "id": "reaction_10656610", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656607" ], "products": [ "species_10649229", "species_10656598", "species_10656603", "species_10649213", "species_10612598", "species_10656593", "species_29372" ], "modifiers": [ [ "species_10656607", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00020425", "WBGene00022460", "Q94392", "WBGene00003818", "WBGene00018853", "WBGene00018239", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657550": { "compartment": "compartment_12045", "id": "reaction_10657550", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10657545" ], "products": [ "species_10657481", "species_29420" ], "modifiers": [ [ "species_10657545", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656618": { "compartment": "compartment_432051", "id": "reaction_10656618", "reactome": "R-CEL-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628218", "species_10656588" ], "products": [ "species_10656612" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "Q9UAQ6", "WBGene00004266", "O17528", "WBGene00004766", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "Q20546", "WBGene00009829", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "O44738", "WBGene00019003", "H2L2E8", "WBGene00006528", "O17528", "WBGene00004766", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P48583", "WBGene00001331", "P12456", "WBGene00003171", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "P34690", "WBGene00006529", "Q18864", "WBGene00004788", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q94241", "WBGene00018853" ] }, "reaction_10647110": { "compartment": "compartment_876", "id": "reaction_10647110", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647066" ], "products": [ "species_29370", "species_10647091" ], "modifiers": [ [ "species_10647066", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647108", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647102": { "compartment": "compartment_876", "id": "reaction_10647102", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647091" ], "products": [ "species_29370", "species_10647093" ], "modifiers": [ [ "species_10647091", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647096", "inhibitor" ], [ "species_10647100", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10665556": { "compartment": "compartment_876", "id": "reaction_10665556", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10647066" ], "products": [ "species_10647098" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647155": { "compartment": "compartment_74700", "id": "reaction_10647155", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647145", "species_10647147", "species_10618746", "species_10647064" ], "products": [ "species_10647149" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10665558": { "compartment": "compartment_876", "id": "reaction_10665558", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647091", "species_9657570" ], "products": [ "species_10647100" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647113": { "compartment": "compartment_876", "id": "reaction_10647113", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647093" ], "products": [ "species_10647054", "species_10647068", "species_10618752", "species_10647089" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186" ] }, "reaction_10665560": { "compartment": "compartment_876", "id": "reaction_10665560", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657574", "species_10647091" ], "products": [ "species_10647096" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647185": { "compartment": "compartment_20699", "id": "reaction_10647185", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647178" ], "products": [ "species_10647182", "species_29370" ], "modifiers": [ [ "species_10647178", "catalyst" ] ], "additional_components": [ "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10647077": { "compartment": "compartment_876", "id": "reaction_10647077", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647054", "species_10647030", "species_10618746", "species_10647064" ], "products": [ "species_10647066" ], "modifiers": [ [ "species_10647075", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647180": { "compartment": "compartment_20699", "id": "reaction_10647180", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10647089", "species_10647176" ], "products": [ "species_10647178" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10665564": { "compartment": "compartment_876", "id": "reaction_10665564", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10647093" ], "products": [ "species_10665562" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9229", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647153": { "compartment": "compartment_74700", "id": "reaction_10647153", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647149" ], "products": [ "species_29370", "species_10647151" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10630903": { "compartment": "compartment_70616", "id": "reaction_10630903", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10630925": { "compartment": "compartment_12045", "id": "reaction_10630925", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10630895": { "compartment": "compartment_12045", "id": "reaction_10630895", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498740", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10631927": { "compartment": "compartment_984", "id": "reaction_10631927", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602402", "species_109276" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10630962": { "compartment": "compartment_70616", "id": "reaction_10630962", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10657697": { "compartment": "compartment_70101", "id": "reaction_10657697", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647007", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947", "Q9XWK4", "WBGene00013202" ] }, "reaction_10657694": { "compartment": "compartment_70101", "id": "reaction_10657694", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647009", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10642565": { "compartment": "compartment_13231", "id": "reaction_10642565", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10641096", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10642747": { "compartment": "compartment_7660", "id": "reaction_10642747", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642729", "species_29358" ], "products": [ "species_113582", "species_10642745" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q21443", "WBGene00003052", "Q21443", "WBGene00003052", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10642573": { "compartment": "compartment_13231", "id": "reaction_10642573", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29496", "species_10642567", "species_5221124" ], "products": [ "species_10642571" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10642190": { "compartment": "compartment_7660", "id": "reaction_10642190", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641096" ], "products": [ "species_113582", "species_10641090" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10641115": { "compartment": "compartment_13231", "id": "reaction_10641115", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10641090" ], "products": [ "species_113550", "species_10641096" ], "modifiers": [ [ "species_10641112", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q9XXN3", "WBGene00011828", "Q20432", "WBGene00018474" ] }, "reaction_10638146": { "compartment": "compartment_70101", "id": "reaction_10638146", "reactome": "R-CEL-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602774" ], "products": [ "species_10638130", "species_29370" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10651289": { "compartment": "compartment_70101", "id": "reaction_10651289", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651285", "species_10617017" ], "products": [ "species_10651287" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488" ] }, "reaction_10651323": { "compartment": "compartment_876", "id": "reaction_10651323", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651319", "species_10612288" ], "products": [ "species_10651321" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006", "WBGene00010664", "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q9XUT0", "WBGene00010664", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006" ] }, "reaction_10617553": { "compartment": "compartment_70101", "id": "reaction_10617553", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617549", "species_10617493" ], "products": [ "species_10617551" ], "modifiers": [], "additional_components": [ "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q21049", "WBGene00006364", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "Q94071", "WBGene00011904", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748" ] }, "reaction_10651237": { "compartment": "compartment_876", "id": "reaction_10651237", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651191", "species_10651233" ], "products": [ "species_10651235" ], "modifiers": [], "additional_components": [ "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10651327": { "compartment": "compartment_876", "id": "reaction_10651327", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651287", "species_10651235" ], "products": [ "species_10651325" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "I2HAJ6", "WBGene00007799", "G5EEG8", "WBGene00001488", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10657531": { "compartment": "compartment_876", "id": "reaction_10657531", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10657527" ], "products": [ "species_10657529" ], "modifiers": [], "additional_components": [ "WBGene00001006", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5ECY0", "WBGene00001006" ] }, "reaction_10644074": { "compartment": "compartment_5460", "id": "reaction_10644074", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_10644070", "species_10644061" ], "products": [ "species_10644072" ], "modifiers": [], "additional_components": [ "Q95QC2", "WBGene00019838", "O44568", "WBGene00020993", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "O44568", "WBGene00020993", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644103": { "compartment": "compartment_5460", "id": "reaction_10644103", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644078", "species_10644092" ], "products": [ "species_10644101" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "WBGene00020625", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644080": { "compartment": "compartment_5460", "id": "reaction_10644080", "reactome": "R-CEL-5419271", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644072" ], "products": [ "species_10644078", "species_10644070", "species_113548", "species_113525", "species_5419287" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "O44568", "WBGene00020993", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q95QC2", "WBGene00019838", "O44568", "WBGene00020993" ] }, "reaction_10644099": { "compartment": "compartment_5460", "id": "reaction_10644099", "reactome": "R-CEL-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644094" ], "products": [ "species_10643799", "species_113548", "species_10644096", "species_10644092", "species_10644042" ], "modifiers": [ [ "species_10644094", "catalyst" ] ], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q95Y73", "WBGene00022491", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "Q11189", "WBGene00015487", "G5EC67", "WBGene00013210", "Q22470", "WBGene00011759", "P49391", "WBGene00011334", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9N361", "WBGene00021920", "Q9U3Q0", "WBGene00007564", "Q9GYI2", "WBGene00017924", "G5ECC9", "WBGene00010766", "Q93425", "WBGene00008452", "Q9NEI6", "WBGene00012697", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "O61818", "WBGene00044321", "P34748", "WBGene00014224", "Q9XTY5", "WBGene00011391", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "Q9NAP9", "WBGene00010624", "G5EFC8", "WBGene00000933", "Q23155", "WBGene00012244", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q19685", "WBGene00009013", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "species_29420", "Q95Y73", "WBGene00022491", "WBGene00020625", "P90915", "WBGene00010616", "Q9TZ90", "WBGene00018793", "Q95QC2", "WBGene00019838", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q21939", "WBGene00011247", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "Q9GYS9", "WBGene00020348", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "O17839", "WBGene00009128", "Q9NAG2", "WBGene00012992", "Q9N3F3", "WBGene00021829", "Q95X39", "WBGene00015025", "P90993", "WBGene00015185", "Q9XX18", "WBGene00012645", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q04907", "WBGene00016249", "Q9UA63", "WBGene00021021", "Q7YWY8", "WBGene00010783", "O18180", "WBGene00012361", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P34264", "WBGene00015133", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q21083", "WBGene00010458", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "Q4W5T0", "WBGene00044344", "Q7YX52", "WBGene00008459", "Q9BL86", "WBGene00021327", "Q9TYJ8", "WBGene00022045", "O45110", "WBGene00018932", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", 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"WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q95Y73", "WBGene00022491", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644059": { "compartment": "compartment_5460", "id": "reaction_10644059", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644055", "species_10644048" ], "products": [ "species_10644057" ], "modifiers": [], "additional_components": [ "Q9XV52", "WBGene00009246", "species_29438", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "Q9XV52", "WBGene00009246", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10630939": { "compartment": "compartment_12045", "id": "reaction_10630939", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10659187": { "compartment": "compartment_12045", "id": "reaction_10659187", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10659184", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10630965": { "compartment": "compartment_12045", "id": "reaction_10630965", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631930": { "compartment": "compartment_984", "id": "reaction_10631930", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10663355": { "compartment": "compartment_5460", "id": "reaction_10663355", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663347" ], "products": [], "modifiers": [ [ "species_10663352", "catalyst" ] ], "additional_components": [ "Q9BKS0", "WBGene00022336", "Q8I7J4", "WBGene00000762", "Q9XWJ5", "WBGene00013094", "P46561", "WBGene00000229", "Q8I4K2", "WBGene00009334", "WBGene00011679" ] }, "reaction_10625828": { "compartment": "compartment_876", "id": "reaction_10625828", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "species_71185", "CHEBI:36144", "species_71185", "CHEBI:36144", "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10629240": { "compartment": "compartment_70101", "id": "reaction_10629240", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_1250243" ], "products": [ "species_10601705" ], "modifiers": [], "additional_components": [ "WBGene00020917", "WBGene00020917" ] }, "reaction_10629211": { "compartment": "compartment_70101", "id": "reaction_10629211", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629198" ], "products": [ "species_29370", "species_10629208" ], "modifiers": [ [ "species_10622456", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004758" ] }, "reaction_10634116": { "compartment": "compartment_70101", "id": "reaction_10634116", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634100" ], "products": [ "species_10634109" ], "modifiers": [ [ "species_10634114", "inhibitor" ] ], "additional_components": [ "P41990", "WBGene00000168", "P41990", "WBGene00000168", "WBGene00004766" ] }, "reaction_10664120": { "compartment": "compartment_7660", "id": "reaction_10664120", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10664115" ], "products": [ "species_113582", "species_10664115" ], "modifiers": [ [ "species_10664117", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10629322": { "compartment": "compartment_70101", "id": "reaction_10629322", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629255" ], "products": [ "species_10629265" ], "modifiers": [ [ "species_10629319", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "O02100", "WBGene00001985", "O45876", "WBGene00000147", "Q9U357", "WBGene00003975", "Q23316", "WBGene00000148", "Q01608", "WBGene00004958", "P52166", "WBGene00004769" ] }, "reaction_10629346": { "compartment": "compartment_70101", "id": "reaction_10629346", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629341", "species_10597908" ], "products": [ "species_10629343" ], "modifiers": [ [ "species_10629341", "catalyst" ] ], "additional_components": [ "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629372": { "compartment": "compartment_70101", "id": "reaction_10629372", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10629265" ], "products": [ "species_10629364" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629357": { "compartment": "compartment_70101", "id": "reaction_10629357", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10629265" ], "products": [ "species_10629355" ], "modifiers": [], "additional_components": [ "WBGene00017131", "P24348", "WBGene00002299", "Q95QN9", "WBGene00017131", "P24348", "WBGene00002299" ] }, "reaction_10629396": { "compartment": "compartment_70101", "id": "reaction_10629396", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629384" ], "products": [ "species_10629394" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10629370": { "compartment": "compartment_70101", "id": "reaction_10629370", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629364" ], "products": [ "species_10629368" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629398": { "compartment": "compartment_70101", "id": "reaction_10629398", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10629382" ], "products": [ "species_10629384" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10664835": { "compartment": "compartment_876", "id": "reaction_10664835", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10615184" ], "products": [ "species_10629334" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00005077", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10629348": { "compartment": "compartment_876", "id": "reaction_10629348", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627496", "species_10629339" ], "products": [ "species_10629341" ], "modifiers": [], "additional_components": [ "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629410": { "compartment": "compartment_70101", "id": "reaction_10629410", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629408" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10634331": { "compartment": "compartment_70101", "id": "reaction_10634331", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634324", "species_10597908" ], "products": [ "species_10634328" ], "modifiers": [ [ "species_10634324", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10629336": { "compartment": "compartment_70101", "id": "reaction_10629336", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629332" ], "modifiers": [ [ "species_10629334", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10634326": { "compartment": "compartment_70101", "id": "reaction_10634326", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627458", "species_10629259" ], "products": [ "species_10634324" ], "modifiers": [], "additional_components": [ "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10605846": { "compartment": "compartment_70101", "id": "reaction_10605846", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840" ], "products": [ "species_10605844" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10605848": { "compartment": "compartment_70101", "id": "reaction_10605848", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840", "species_10605825", "species_10605830" ], "products": [ "species_10605842" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q21776", "WBGene00000275", "O02053", "WBGene00004721", "WBGene00013209", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "O02053", "WBGene00004721", "Q09373", "WBGene00001511" ] }, "reaction_10607997": { "compartment": "compartment_7660", "id": "reaction_10607997", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607992" ], "products": [ "species_113582", "species_10607994" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10605577": { "compartment": "compartment_70101", "id": "reaction_10605577", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10605570" ], "products": [ "species_10605572" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619745": { "compartment": "compartment_876", "id": "reaction_10619745", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619741", "species_114519" ], "products": [ "species_10619743" ], "modifiers": [], "additional_components": [ "P34586", "WBGene00006614", "G5EF09", "WBGene00004976", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10619520": { "compartment": "compartment_70101", "id": "reaction_10619520", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610919", "species_114519" ], "products": [ "species_10619518" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10649353": { "compartment": "compartment_876", "id": "reaction_10649353", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694509", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10649350", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10605575": { "compartment": "compartment_114521", "id": "reaction_10605575", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10605572", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619788": { "compartment": "compartment_70101", "id": "reaction_10619788", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10619785", "catalyst" ] ], "additional_components": [ "H2KZC9", "WBGene00006483", "Q03603", "WBGene00000960", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958", "Q10024", "WBGene00019428" ] }, "reaction_10619647": { "compartment": "compartment_876", "id": "reaction_10619647", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10619644", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10650309": { "compartment": "compartment_70101", "id": "reaction_10650309", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788291", "species_29356" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10650306", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_109496" ] }, "reaction_10602217": { "compartment": "compartment_70101", "id": "reaction_10602217", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q23588", "WBGene00022817" ] }, "reaction_10601699": { "compartment": "compartment_70101", "id": "reaction_10601699", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10601696", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10662627": { "compartment": "compartment_70101", "id": "reaction_10662627", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10662624", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "WBGene00008948" ] }, "reaction_10601683": { "compartment": "compartment_70101", "id": "reaction_10601683", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10601680", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_216667", "Q20628", "WBGene00000392" ] }, "reaction_10601663": { "compartment": "compartment_70101", "id": "reaction_10601663", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10601660", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604531": { "compartment": "compartment_70101", "id": "reaction_10604531", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10604528", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604921": { "compartment": "compartment_70101", "id": "reaction_10604921", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604918", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10661713": { "compartment": "compartment_70101", "id": "reaction_10661713", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10604862" ], "products": [ "species_10604864" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389" ] }, "reaction_10621546": { "compartment": "compartment_70101", "id": "reaction_10621546", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10621538" ], "products": [ "species_113582", "species_10621543" ], "modifiers": [ [ "species_10621538", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604963": { "compartment": "compartment_876", "id": "reaction_10604963", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604936" ], "products": [ "species_29370", "species_10604960" ], "modifiers": [ [ "species_10604954", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604900": { "compartment": "compartment_876", "id": "reaction_10604900", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10604895", "catalyst" ], [ "species_10604898", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604956": { "compartment": "compartment_70101", "id": "reaction_10604956", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604898" ], "products": [ "species_10604938" ], "modifiers": [ [ "species_10604954", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "Q09639", "WBGene00001709", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604868": { "compartment": "compartment_70101", "id": "reaction_10604868", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604864" ], "products": [ "species_10604866", "species_10604860" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10604923": { "compartment": "compartment_70101", "id": "reaction_10604923", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604918" ], "products": [ "species_10604918" ], "modifiers": [ [ "species_10604898", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10651257": { "compartment": "compartment_70101", "id": "reaction_10651257", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10651245" ], "products": [ "species_29370", "species_10651255" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655489": { "compartment": "compartment_70101", "id": "reaction_10655489", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655483" ], "products": [ "species_10655487" ], "modifiers": [], "additional_components": [ "WBGene00009647", "WBGene00009647" ] }, "reaction_10645807": { "compartment": "compartment_70101", "id": "reaction_10645807", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645791", "species_10645799" ], "products": [ "species_10645805" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598469": { "compartment": "compartment_70101", "id": "reaction_10598469", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10598466", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10599754": { "compartment": "compartment_70101", "id": "reaction_10599754", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10599751", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10651416": { "compartment": "compartment_7660", "id": "reaction_10651416", "reactome": "R-CEL-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651410", "species_29358" ], "products": [ "species_113582", "species_10651414" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003150", "WBGene00003150", "WBGene00000227" ] }, "reaction_10639605": { "compartment": "compartment_70101", "id": "reaction_10639605", "reactome": "R-CEL-3341277", "name": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10636065", "catalyst" ] ], "additional_components": [ "Q93204", "WBGene00007516" ] }, "reaction_10655691": { "compartment": "compartment_70101", "id": "reaction_10655691", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655683" ], "products": [ "species_10655685" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10645811": { "compartment": "compartment_70101", "id": "reaction_10645811", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617093", "species_10645799" ], "products": [ "species_10645809" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "WBGene00022279", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q9N4D6", "WBGene00022279", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10655536": { "compartment": "compartment_876", "id": "reaction_10655536", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655527", "species_10655532" ], "products": [ "species_10655534" ], "modifiers": [], "additional_components": [ "WBGene00019778", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10662505": { "compartment": "compartment_7660", "id": "reaction_10662505", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662497" ], "products": [ "species_10662503" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10662495": { "compartment": "compartment_7660", "id": "reaction_10662495", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491" ], "products": [ "species_10662493" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10655485": { "compartment": "compartment_7660", "id": "reaction_10655485", "reactome": "R-CEL-6800490", "name": "ATM phosphorylates PIDD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10655480" ], "products": [ "species_113582", "species_10655483" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00009647", "WBGene00009647", "WBGene00000227" ] }, "reaction_10598826": { "compartment": "compartment_5460", "id": "reaction_10598826", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113522" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10598823", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q93650", "WBGene00009271", "Q19013", "WBGene00008435" ] }, "reaction_10660349": { "compartment": "compartment_7660", "id": "reaction_10660349", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625955", "species_10660342" ], "products": [ "species_10660347" ], "modifiers": [], "additional_components": [ "WBGene00022448", "Q9BL73", "WBGene00004088", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10651355": { "compartment": "compartment_7660", "id": "reaction_10651355", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651335", "species_10651264" ], "products": [ "species_10651337" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655689": { "compartment": "compartment_70101", "id": "reaction_10655689", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655677", "species_10655685" ], "products": [ "species_10655687" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "P41932", "WBGene00003920", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10645794": { "compartment": "compartment_70101", "id": "reaction_10645794", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10639622" ], "products": [ "species_10645791", "species_29356" ], "modifiers": [ [ "species_10639622", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598605": { "compartment": "compartment_70101", "id": "reaction_10598605", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10598600", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10651266": { "compartment": "compartment_7660", "id": "reaction_10651266", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651262" ], "products": [ "species_10651264" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10660345": { "compartment": "compartment_7660", "id": "reaction_10660345", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10660331" ], "products": [ "species_113582", "species_10660342" ], "modifiers": [ [ "species_10622470", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10651272": { "compartment": "compartment_7660", "id": "reaction_10651272", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651268" ], "products": [ "species_10651270" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10662501": { "compartment": "compartment_7660", "id": "reaction_10662501", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491", "species_10662497" ], "products": [ "species_10662499" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10639631": { "compartment": "compartment_70101", "id": "reaction_10639631", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10601707" ], "products": [ "species_29356", "species_10601705" ], "modifiers": [ [ "species_10639628", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10651247": { "compartment": "compartment_70101", "id": "reaction_10651247", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637490" ], "products": [ "species_29370", "species_10651245" ], "modifiers": [ [ "species_10611000", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583" ] }, "reaction_10655545": { "compartment": "compartment_70101", "id": "reaction_10655545", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655534", "species_10655541" ], "products": [ "species_10655543" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10617109": { "compartment": "compartment_70101", "id": "reaction_10617109", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106", "species_29372" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10651353": { "compartment": "compartment_7660", "id": "reaction_10651353", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10651337" ], "products": [ "species_113582", "species_10651350" ], "modifiers": [ [ "species_10651337", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655741": { "compartment": "compartment_7660", "id": "reaction_10655741", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605168", "species_10655737" ], "products": [ "species_10655739" ], "modifiers": [], "additional_components": [ "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P41848", "WBGene00001974", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849" ] }, "reaction_10614736": { "compartment": "compartment_984", "id": "reaction_10614736", "reactome": "R-CEL-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10614732" ], "products": [ "species_10614734" ], "modifiers": [], "additional_components": [ "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "species_265479", "Q19127", "WBGene00003561", "P34389", "WBGene00003562" ] }, "reaction_10661657": { "compartment": "compartment_70101", "id": "reaction_10661657", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661653" ], "products": [ "species_10661655" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661663": { "compartment": "compartment_70101", "id": "reaction_10661663", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559", "species_10661617" ], "products": [ "species_10661653" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10617891": { "compartment": "compartment_984", "id": "reaction_10617891", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10617885": { "compartment": "compartment_984", "id": "reaction_10617885", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616519" ], "products": [ "species_10616523" ], "modifiers": [ [ "species_10617883", "catalyst" ], [ "species_10617881", "inhibitor" ] ], "additional_components": [ "species_374935", "species_209794", "WBGene00008890", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=483", "LigandDisplayForward?ligandId=485", "LigandDisplayForward?ligandId=124", "LigandDisplayForward?ligandId=480", "LigandDisplayForward?ligandId=3469", "LigandDisplayForward?ligandId=481", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=7302", "LigandDisplayForward?ligandId=503", "LigandDisplayForward?ligandId=7170" ] }, "reaction_10656795": { "compartment": "compartment_70101", "id": "reaction_10656795", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610899", "species_29356" ], "products": [ "species_29372", "species_10617854" ], "modifiers": [ [ "species_10656790", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10636518": { "compartment": "compartment_70101", "id": "reaction_10636518", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636515", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "species_179838", "Q10656", "WBGene00001184", "Q45FX5", "WBGene00006887", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "O18008", "WBGene00021745" ] }, "reaction_10633249": { "compartment": "compartment_876", "id": "reaction_10633249", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633061": { "compartment": "compartment_876", "id": "reaction_10633061", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633058", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10658313": { "compartment": "compartment_70101", "id": "reaction_10658313", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610622", "species_113592" ], "products": [ "species_29370", "species_10658301" ], "modifiers": [ [ "species_10658310", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [ "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10642713": { "compartment": "compartment_70101", "id": "reaction_10642713", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612004", "species_113592" ], "products": [ "species_29370", "species_10610661" ], "modifiers": [ [ "species_10612004", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10661437": { "compartment": "compartment_7660", "id": "reaction_10661437", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661433", "species_10639314" ], "products": [ "species_10661435" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10635829": { "compartment": "compartment_70101", "id": "reaction_10635829", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613633", "species_10610677" ], "products": [ "species_10635827" ], "modifiers": [], "additional_components": [ "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610705": { "compartment": "compartment_70101", "id": "reaction_10610705", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610692", "species_113592" ], "products": [ "species_10610672", "species_29370" ], "modifiers": [ [ "species_10610692", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10635835": { "compartment": "compartment_70101", "id": "reaction_10635835", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635831" ], "products": [ "species_10613633", "species_10635833", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10635837": { "compartment": "compartment_70101", "id": "reaction_10635837", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635827", "species_10597908" ], "products": [ "species_10635831" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10641384": { "compartment": "compartment_7660", "id": "reaction_10641384", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639298" ], "products": [ "species_10639314" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10610714": { "compartment": "compartment_70101", "id": "reaction_10610714", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610709", "species_113592" ], "products": [ "species_29370", "species_10610699" ], "modifiers": [ [ "species_10610709", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610684": { "compartment": "compartment_70101", "id": "reaction_10610684", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610677" ], "products": [ "species_10610677" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610702": { "compartment": "compartment_70101", "id": "reaction_10610702", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610699" ], "products": [ "species_29370", "species_10610688" ], "modifiers": [ [ "species_10610699", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610711": { "compartment": "compartment_70101", "id": "reaction_10610711", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610661", "species_10610707" ], "products": [ "species_10610709" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00001979", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610695": { "compartment": "compartment_70101", "id": "reaction_10610695", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610688" ], "products": [ "species_29370", "species_10610692" ], "modifiers": [ [ "species_10610688", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10643089": { "compartment": "compartment_7660", "id": "reaction_10643089", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638387", "species_10639287" ], "products": [ "species_10643087" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10610682": { "compartment": "compartment_70101", "id": "reaction_10610682", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610672", "species_113592" ], "products": [ "species_29370", "species_10610677" ], "modifiers": [ [ "species_10610672", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10654727": { "compartment": "compartment_70101", "id": "reaction_10654727", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10654724", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10598546": { "compartment": "compartment_70101", "id": "reaction_10598546", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29360", "species_29372" ], "products": [ "species_70106", "species_73473", "species_29800" ], "modifiers": [ [ "species_10598543", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17331", "WBGene00001686", "P17329", "WBGene00001684", "P17330", "WBGene00001685" ] }, "reaction_10599692": { "compartment": "compartment_70101", "id": "reaction_10599692", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29492", "species_29356" ], "modifiers": [ [ "species_10598654", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_109496" ] }, "reaction_10599874": { "compartment": "compartment_70101", "id": "reaction_10599874", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10598638", "catalyst" ] ], "additional_components": [ "P91427", "WBGene00020185", "species_109496" ] }, "reaction_10649423": { "compartment": "compartment_12045", "id": "reaction_10649423", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10649420", "catalyst" ] ], "additional_components": [ "Q86S40", "WBGene00016810", "species_109496" ] }, "reaction_10598593": { "compartment": "compartment_70101", "id": "reaction_10598593", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10598590", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10598507": { "compartment": "compartment_70101", "id": "reaction_10598507", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10598504", "catalyst" ] ], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599870": { "compartment": "compartment_70101", "id": "reaction_10599870", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10599867", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10662663": { "compartment": "compartment_70101", "id": "reaction_10662663", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10598402", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10599719": { "compartment": "compartment_70101", "id": "reaction_10599719", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10599716", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001", "species_74126", "species_109496" ] }, "reaction_10598391": { "compartment": "compartment_70101", "id": "reaction_10598391", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598388", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295" ] }, "reaction_10598556": { "compartment": "compartment_70101", "id": "reaction_10598556", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10598553", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10607710": { "compartment": "compartment_13231", "id": "reaction_10607710", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607708" ], "products": [ "species_10598486" ], "modifiers": [], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10599566", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10625184": { "compartment": "compartment_5460", "id": "reaction_10625184", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_880046", "species_113526" ], "products": [ "species_113536", "species_29362", "species_113529" ], "modifiers": [ [ "species_10625181", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10625666": { "compartment": "compartment_5460", "id": "reaction_10625666", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10625663", "catalyst" ] ], "additional_components": [ "Q21217", "WBGene00001794", "CHEBI:33739" ] }, "reaction_10641688": { "compartment": "compartment_7660", "id": "reaction_10641688", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_77087" ], "products": [ "species_10641673", "species_77502" ], "modifiers": [ [ "species_10641685", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10642433": { "compartment": "compartment_7660", "id": "reaction_10642433", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642398", "species_77087" ], "products": [ "species_10642431", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00013766" ] }, "reaction_10646433": { "compartment": "compartment_7660", "id": "reaction_10646433", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642265", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10646024": { "compartment": "compartment_7660", "id": "reaction_10646024", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646006", "species_77087" ], "products": [ "species_77502", "species_10646022" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10638598": { "compartment": "compartment_7660", "id": "reaction_10638598", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586" ], "products": [ "species_29478", "species_10638588" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10642756": { "compartment": "compartment_7660", "id": "reaction_10642756", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_77087" ], "products": [ "species_10642749", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ], [ "species_10642358", "inhibitor" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10642562": { "compartment": "compartment_7660", "id": "reaction_10642562", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10642554", "species_77502" ], "modifiers": [ [ "species_10642559", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012298" ] }, "reaction_10641713": { "compartment": "compartment_7660", "id": "reaction_10641713", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10641526", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646014": { "compartment": "compartment_7660", "id": "reaction_10646014", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645998", "species_77087" ], "products": [ "species_10646006", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10641594": { "compartment": "compartment_7660", "id": "reaction_10641594", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10638586", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10640230": { "compartment": "compartment_7660", "id": "reaction_10640230", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640227", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "Q18919", "WBGene00005006", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "Q95Y41", "WBGene00022278" ] }, "reaction_10641550": { "compartment": "compartment_7660", "id": "reaction_10641550", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10639479": { "compartment": "compartment_7660", "id": "reaction_10639479", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639441", "species_113560" ], "products": [ "species_10639476", "species_2485002" ], "modifiers": [ [ "species_10607230", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10646440": { "compartment": "compartment_7660", "id": "reaction_10646440", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10642265" ], "products": [ "species_10646438", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10646427": { "compartment": "compartment_7660", "id": "reaction_10646427", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10646028", "species_113685" ], "products": [ "species_159942", "species_10641602", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10642588": { "compartment": "compartment_7660", "id": "reaction_10642588", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614312", "species_10638588" ], "products": [ "species_10642586" ], "modifiers": [ [ "species_10642554", "inhibitor" ] ], "additional_components": [ "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10641564": { "compartment": "compartment_7660", "id": "reaction_10641564", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641547", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646429": { "compartment": "compartment_7660", "id": "reaction_10646429", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642356", "species_113671", "species_113685" ], "products": [ "species_10638866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10639435": { "compartment": "compartment_7660", "id": "reaction_10639435", "reactome": "R-CEL-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639388", "species_113560" ], "products": [ "species_2485002", "species_10639394" ], "modifiers": [ [ "species_10639432", "catalyst" ] ], "additional_components": [ "WBGene00001914", "WBGene00001914", "A3QMD7", "WBGene00020287", "Q95ZX6", "WBGene00007914", "Q9N3F6", "WBGene00021810", "Q8WQC3", "WBGene00015001" ] }, "reaction_10641627": { "compartment": "compartment_7660", "id": "reaction_10641627", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641602", "species_113671", "species_113685" ], "products": [ "species_10641610", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646425": { "compartment": "compartment_7660", "id": "reaction_10646425", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641673", "species_113685" ], "products": [ "species_10641545", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10641572": { "compartment": "compartment_7660", "id": "reaction_10641572", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638866", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10645990": { "compartment": "compartment_7660", "id": "reaction_10645990", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641526", "species_77087" ], "products": [ "species_10645980", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646415": { "compartment": "compartment_7660", "id": "reaction_10646415", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642749", "species_113685" ], "products": [ "species_10641580", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10645875": { "compartment": "compartment_70101", "id": "reaction_10645875", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10645859" ], "products": [ "species_71285", "species_10645865" ], "modifiers": [ [ "species_10645870", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00001207" ] }, "reaction_10642584": { "compartment": "compartment_7660", "id": "reaction_10642584", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641985", "species_10642554" ], "products": [ "species_10642582" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10645934": { "compartment": "compartment_7660", "id": "reaction_10645934", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586", "species_77087" ], "products": [ "species_10641580", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10641543": { "compartment": "compartment_7660", "id": "reaction_10641543", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641526", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646413": { "compartment": "compartment_7660", "id": "reaction_10646413", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646026": { "compartment": "compartment_7660", "id": "reaction_10646026", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10645998", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10646431": { "compartment": "compartment_7660", "id": "reaction_10646431", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580" ], "products": [ "species_10638586", "species_29478" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10640361": { "compartment": "compartment_7660", "id": "reaction_10640361", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640358", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q20296", "WBGene00018319", "Q8I4I9", "WBGene00009663", "Q9U266", "WBGene00001838" ] }, "reaction_10646411": { "compartment": "compartment_7660", "id": "reaction_10646411", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645980", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10641526", "species_29478" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646435": { "compartment": "compartment_7660", "id": "reaction_10646435", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642363", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10642265" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10644106": { "compartment": "compartment_7660", "id": "reaction_10644106", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_77502", "species_10636181" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10644109": { "compartment": "compartment_7660", "id": "reaction_10644109", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10636181" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10636190", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10641995": { "compartment": "compartment_7660", "id": "reaction_10641995", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10638586", "species_77502" ], "modifiers": [ [ "species_10641992", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10640129": { "compartment": "compartment_7660", "id": "reaction_10640129", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639929", "species_113560" ], "products": [ "species_2485002", "species_10640126" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00000366" ] }, "reaction_10642268": { "compartment": "compartment_7660", "id": "reaction_10642268", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_10642265", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10639915": { "compartment": "compartment_7660", "id": "reaction_10639915", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_113560" ], "products": [ "species_2485002", "species_10639905" ], "modifiers": [ [ "species_10639912", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q21484", "WBGene00044069" ] }, "reaction_10617848": { "compartment": "compartment_17951", "id": "reaction_10617848", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_141343" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10617805": { "compartment": "compartment_17951", "id": "reaction_10617805", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10617802", "catalyst" ] ], "additional_components": [ "Q20992", "WBGene00019060", "species_113596" ] }, "reaction_10617812": { "compartment": "compartment_17951", "id": "reaction_10617812", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617810": { "compartment": "compartment_17951", "id": "reaction_10617810", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617814": { "compartment": "compartment_17951", "id": "reaction_10617814", "reactome": "R-CEL-390224", "name": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389996", "species_193514" ], "products": [ "species_390002", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10617795": { "compartment": "compartment_17951", "id": "reaction_10617795", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10617807": { "compartment": "compartment_17951", "id": "reaction_10617807", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10617835": { "compartment": "compartment_17951", "id": "reaction_10617835", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_390271" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10617832", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10617845": { "compartment": "compartment_17951", "id": "reaction_10617845", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_353123" ], "products": [ "species_193514", "species_390287" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10617843": { "compartment": "compartment_17951", "id": "reaction_10617843", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_192314" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10610040": { "compartment": "compartment_70101", "id": "reaction_10610040", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10610037", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10610751": { "compartment": "compartment_70101", "id": "reaction_10610751", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196420" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610020": { "compartment": "compartment_70101", "id": "reaction_10610020", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10610017", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10661829": { "compartment": "compartment_70101", "id": "reaction_10661829", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10661826", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10642772": { "compartment": "compartment_17957", "id": "reaction_10642772", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10642769", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10610030": { "compartment": "compartment_70101", "id": "reaction_10610030", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10610027", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10610012": { "compartment": "compartment_70101", "id": "reaction_10610012", "reactome": "R-CEL-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10610050": { "compartment": "compartment_70101", "id": "reaction_10610050", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10610047", "catalyst" ] ], "additional_components": [ "G5EFQ1", "WBGene00019460", "species_109496" ] }, "reaction_10666341": { "compartment": "compartment_12045", "id": "reaction_10666341", "reactome": "R-CEL-9755937", "name": "DHCR24 reduces LAN to 24,25-dhLAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634" ], "products": [ "species_29366", "species_1130708" ], "modifiers": [ [ "species_10610748", "catalyst" ], [ "species_10666337", "catalyst" ] ], "additional_components": [ "WBGene00018718", "WBGene00004735" ] }, "reaction_10610068": { "compartment": "compartment_70101", "id": "reaction_10610068", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10610065", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10610060": { "compartment": "compartment_70101", "id": "reaction_10610060", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10610057", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10655790": { "compartment": "compartment_12045", "id": "reaction_10655790", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_29366", "species_6807048" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610015": { "compartment": "compartment_70101", "id": "reaction_10610015", "reactome": "R-CEL-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10655788": { "compartment": "compartment_12045", "id": "reaction_10655788", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6807057" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10610743": { "compartment": "compartment_70101", "id": "reaction_10610743", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_195655" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10638184": { "compartment": "compartment_7660", "id": "reaction_10638184", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638084", "species_10638173" ], "products": [ "species_10638181", "species_10638069" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10655749": { "compartment": "compartment_984", "id": "reaction_10655749", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614867" ], "products": [ "species_10655694" ], "modifiers": [], "additional_components": [ "WBGene00001972", "WBGene00001972" ] }, "reaction_10655698": { "compartment": "compartment_984", "id": "reaction_10655698", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_181015" ], "products": [ "species_10655696" ], "modifiers": [], "additional_components": [ "WBGene00001972", "Q09390", "WBGene00001972", "species_181015" ] }, "reaction_10659495": { "compartment": "compartment_984", "id": "reaction_10659495", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10607100" ], "products": [ "species_10659493" ], "modifiers": [], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_2186967", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563" ] }, "reaction_10655702": { "compartment": "compartment_984", "id": "reaction_10655702", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_166005" ], "products": [ "species_10655700" ], "modifiers": [], "additional_components": [ "WBGene00001972", "species_166005", "Q09390", "WBGene00001972" ] }, "reaction_10607106": { "compartment": "compartment_984", "id": "reaction_10607106", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607100", "species_166005" ], "products": [ "species_10607102" ], "modifiers": [ [ "species_10607104", "inhibitor" ] ], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_166005", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "WBGene00022627" ] }, "reaction_10661651": { "compartment": "compartment_70101", "id": "reaction_10661651", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661647" ], "products": [ "species_10661649" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661665": { "compartment": "compartment_70101", "id": "reaction_10661665", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625310", "species_10628559" ], "products": [ "species_10628565" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661629": { "compartment": "compartment_70101", "id": "reaction_10661629", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661619" ], "products": [ "species_10661627" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661661": { "compartment": "compartment_70101", "id": "reaction_10661661", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661617" ], "products": [ "species_10661619" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661659": { "compartment": "compartment_70101", "id": "reaction_10661659", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628565" ], "products": [ "species_10628577" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10611863": { "compartment": "compartment_70101", "id": "reaction_10611863", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611857" ], "products": [ "species_10611861", "species_10611859" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000072", "WBGene00000072", "WBGene00000072", "P42573", "WBGene00000417" ] }, "reaction_10611874": { "compartment": "compartment_70101", "id": "reaction_10611874", "reactome": "R-CEL-201622", "name": "Caspase-mediated cleavage of gelsolin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611868" ], "products": [ "species_10611870", "species_10611872" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010593", "WBGene00010593", "WBGene00010593", "P42573", "WBGene00000417" ] }, "reaction_10612305": { "compartment": "compartment_70101", "id": "reaction_10612305", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612299" ], "products": [ "species_10612303", "species_10612301" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10612294": { "compartment": "compartment_70101", "id": "reaction_10612294", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612288" ], "products": [ "species_10612290", "species_10612292" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10636129": { "compartment": "compartment_161320", "id": "reaction_10636129", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_1678868", "species_2162223" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10665108": { "compartment": "compartment_161320", "id": "reaction_10665108", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636011": { "compartment": "compartment_161320", "id": "reaction_10636011", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160864", "species_1605715" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10636127": { "compartment": "compartment_161320", "id": "reaction_10636127", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162224", "species_1605715" ], "products": [ "species_1678868", "species_1678743" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10636032": { "compartment": "compartment_876", "id": "reaction_10636032", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636029" ], "products": [ "species_2160894", "species_10636029" ], "modifiers": [ [ "species_10636029", "catalyst" ] ], "additional_components": [ "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10636125": { "compartment": "compartment_161320", "id": "reaction_10636125", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10609537": { "compartment": "compartment_7660", "id": "reaction_10609537", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609448" ], "products": [ "species_10598143", "species_10609440", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609431": { "compartment": "compartment_7660", "id": "reaction_10609431", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609423" ], "products": [ "species_113582", "species_10609428" ], "modifiers": [ [ "species_10609423", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598270": { "compartment": "compartment_7660", "id": "reaction_10598270", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598260" ], "products": [ "species_10598262" ], "modifiers": [ [ "species_10598267", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00000794" ] }, "reaction_10609442": { "compartment": "compartment_7660", "id": "reaction_10609442", "reactome": "R-CEL-187545", "name": "Association of Cks1 with SCF(Skp2) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609433", "species_10609438" ], "products": [ "species_10609440" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "WBGene00001051", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10598156": { "compartment": "compartment_70101", "id": "reaction_10598156", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598154" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P91155", "WBGene00000382", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609606": { "compartment": "compartment_7660", "id": "reaction_10609606", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609602" ], "products": [ "species_113582", "species_10609604" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609421": { "compartment": "compartment_13231", "id": "reaction_10609421", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419" ], "products": [ "species_10598355" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10598146": { "compartment": "compartment_7660", "id": "reaction_10598146", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597697" ], "products": [ "species_113582", "species_10598123" ], "modifiers": [ [ "species_10598143", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597902": { "compartment": "compartment_7660", "id": "reaction_10597902", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597874", "species_10597841" ], "products": [ "species_10597877" ], "modifiers": [ [ "species_10597899", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00012650", "WBGene00012650", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10598204": { "compartment": "compartment_7660", "id": "reaction_10598204", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598198" ], "products": [ "species_10598185", "species_10598202" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10608079": { "compartment": "compartment_13231", "id": "reaction_10608079", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607961" ], "products": [ "species_10607975" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609540": { "compartment": "compartment_7660", "id": "reaction_10609540", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609444", "species_10597874" ], "products": [ "species_10609448" ], "modifiers": [ [ "species_10609444", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051", "WBGene00006727", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598158": { "compartment": "compartment_7660", "id": "reaction_10598158", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597820" ], "products": [ "species_10597811", "species_10597804", "species_10597787", "species_10597816" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "WBGene00003157" ] }, "reaction_10598150": { "compartment": "compartment_7660", "id": "reaction_10598150", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598123" ], "products": [ "species_10598148" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10636953": { "compartment": "compartment_7660", "id": "reaction_10636953", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636933", "species_113560" ], "products": [ "species_2485002", "species_10636941" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10597749": { "compartment": "compartment_7660", "id": "reaction_10597749", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10597744" ], "products": [ "species_10597740", "species_10597746" ], "modifiers": [ [ "species_10597744", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10598258": { "compartment": "compartment_7660", "id": "reaction_10598258", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598249", "species_10598254" ], "products": [ "species_10598256" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00001016", "Q9U3F2", "WBGene00001016", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10610968": { "compartment": "compartment_70101", "id": "reaction_10610968", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419", "species_113592" ], "products": [ "species_29370", "species_10610965" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10597906": { "compartment": "compartment_7660", "id": "reaction_10597906", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597877" ], "products": [ "species_10597904" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10636990": { "compartment": "compartment_7660", "id": "reaction_10636990", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636986", "species_113560" ], "products": [ "species_2485002", "species_10636988" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10598189": { "compartment": "compartment_7660", "id": "reaction_10598189", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113", "species_10598185" ], "products": [ "species_10598187" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10598200": { "compartment": "compartment_7660", "id": "reaction_10598200", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598196", "species_10598187" ], "products": [ "species_113582", "species_10598198" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10608402": { "compartment": "compartment_7660", "id": "reaction_10608402", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608388", "species_10608383", "species_10608393", "species_10608398" ], "products": [ "species_10608400" ], "modifiers": [], "additional_components": [ "WBGene00009287", "WBGene00011275", "WBGene00022043", "WBGene00013768", "Q9U2W9", "WBGene00013768", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043", "Q22019", "WBGene00011275" ] }, "reaction_10598232": { "compartment": "compartment_7660", "id": "reaction_10598232", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598225" ], "products": [ "species_10598229" ], "modifiers": [ [ "species_10598223", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645" ] }, "reaction_10607963": { "compartment": "compartment_70101", "id": "reaction_10607963", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10607594" ], "products": [ "species_10607961" ], "modifiers": [], "additional_components": [ "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609608": { "compartment": "compartment_7660", "id": "reaction_10609608", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_29358" ], "products": [ "species_113582", "species_10597866" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10598278": { "compartment": "compartment_7660", "id": "reaction_10598278", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10609598": { "compartment": "compartment_7660", "id": "reaction_10609598", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609593" ], "products": [ "species_113582", "species_10609595" ], "modifiers": [ [ "species_10609593", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598116": { "compartment": "compartment_7660", "id": "reaction_10598116", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10597746", "species_29604", "species_29892" ], "products": [ "species_10598113" ], "modifiers": [ [ "species_10597721", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10597869": { "compartment": "compartment_7660", "id": "reaction_10597869", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597822" ], "products": [ "species_10597845", "species_113582", "species_10597841" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00012650", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609446": { "compartment": "compartment_7660", "id": "reaction_10609446", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10609428" ], "products": [ "species_10609444" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598227": { "compartment": "compartment_7660", "id": "reaction_10598227", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598202", "species_10598223" ], "products": [ "species_10598225" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598236": { "compartment": "compartment_7660", "id": "reaction_10598236", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598229" ], "products": [ "species_10598234" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598111": { "compartment": "compartment_70101", "id": "reaction_10598111", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597904" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00012650", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607697": { "compartment": "compartment_876", "id": "reaction_10607697", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607678" ], "products": [ "species_10607692", "species_29372" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607687": { "compartment": "compartment_876", "id": "reaction_10607687", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607685" ], "products": [ "species_10607683", "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10608410": { "compartment": "compartment_70101", "id": "reaction_10608410", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608404" ], "products": [ "species_29370", "species_10608407" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10607674": { "compartment": "compartment_876", "id": "reaction_10607674", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607671", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "species_29420", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607694": { "compartment": "compartment_876", "id": "reaction_10607694", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607692" ], "products": [ "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10607216": { "compartment": "compartment_70101", "id": "reaction_10607216", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607202" ], "products": [ "species_10607214", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "species_29420", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681" ] }, "reaction_10607219": { "compartment": "compartment_70101", "id": "reaction_10607219", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607214" ], "products": [ "species_10605068" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "G5ECT6", "WBGene00001682", "Q09502", "WBGene00008065", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_29438", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "WBGene00001196" ] }, "reaction_10604848": { "compartment": "compartment_70101", "id": "reaction_10604848", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10607198": { "compartment": "compartment_947587", "id": "reaction_10607198", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843", "species_29420" ], "products": [ "species_29438", "species_10604969" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "WBGene00001196" ] }, "reaction_10665289": { "compartment": "compartment_70101", "id": "reaction_10665289", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10608407", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10604971": { "compartment": "compartment_70101", "id": "reaction_10604971", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604845", "species_29356" ], "products": [ "species_10604832", "species_10604969", "species_29372" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "WBGene00001177", "species_29420", "G5EGU1", "WBGene00001196" ] }, "reaction_10607700": { "compartment": "compartment_876", "id": "reaction_10607700", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607685", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10604931": { "compartment": "compartment_70101", "id": "reaction_10604931", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10607690": { "compartment": "compartment_876", "id": "reaction_10607690", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607221": { "compartment": "compartment_947587", "id": "reaction_10607221", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604969", "species_10605064" ], "products": [ "species_10607200" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10607676": { "compartment": "compartment_876", "id": "reaction_10607676", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607665", "species_10607647" ], "products": [ "species_10607667" ], "modifiers": [], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "species_109496", "Q9N2V6", "WBGene00001678", "Q966F9", "WBGene00000071", "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607681": { "compartment": "compartment_876", "id": "reaction_10607681", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607647", "species_10604895" ], "products": [ "species_10607678" ], "modifiers": [ [ "species_10604895", "catalyst" ] ], "additional_components": [ "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071" ] }, "reaction_10628746": { "compartment": "compartment_1222693", "id": "reaction_10628746", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10628743", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10650440": { "compartment": "compartment_21994", "id": "reaction_10650440", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10650430" ], "products": [ "species_10650432" ], "modifiers": [], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650435": { "compartment": "compartment_21994", "id": "reaction_10650435", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650432", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10658173": { "compartment": "compartment_984", "id": "reaction_10658173", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10658170", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650438": { "compartment": "compartment_1222282", "id": "reaction_10650438", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10660758": { "compartment": "compartment_1222282", "id": "reaction_10660758", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10621247": { "compartment": "compartment_172574", "id": "reaction_10621247", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10621244", "catalyst" ] ], "additional_components": [ "species_216667", "species_113531", "species_266099", "species_216667", "species_113531", "species_266099", "Q21434", "WBGene00004876", "Q21433", "WBGene00004877", "Q95XG8", "WBGene00004878" ] }, "reaction_10664718": { "compartment": "compartment_70101", "id": "reaction_10664718", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647011", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665968": { "compartment": "compartment_7660", "id": "reaction_10665968", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611187" ], "products": [ "species_10664881" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10665966": { "compartment": "compartment_7660", "id": "reaction_10665966", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662906": { "compartment": "compartment_876", "id": "reaction_10662906", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10662895" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10636260": { "compartment": "compartment_70101", "id": "reaction_10636260", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10636257", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10624986": { "compartment": "compartment_876", "id": "reaction_10624986", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605064", "species_10607683" ], "products": [ "species_10616840" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10655747": { "compartment": "compartment_984", "id": "reaction_10655747", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6805204", "species_10655743" ], "products": [ "species_10655745" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_6805204" ] }, "reaction_10624999": { "compartment": "compartment_876", "id": "reaction_10624999", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618849", "species_10605064" ], "products": [ "species_10605451" ], "modifiers": [], "additional_components": [ "species_111349", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616840", "species_10616838" ], "products": [ "species_10616842" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794" ] }, "reaction_10618991": { "compartment": "compartment_984", "id": "reaction_10618991", "reactome": "R-CEL-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616818", "species_419339" ], "products": [ "species_10616820" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "species_419339", "P91439", "WBGene00020319", "O76667", "WBGene00019183" ] }, "reaction_10666012": { "compartment": "compartment_70101", "id": "reaction_10666012", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10666009", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10617905": { "compartment": "compartment_984", "id": "reaction_10617905", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616408", "species_114523" ], "products": [ "species_10616410" ], "modifiers": [], "additional_components": [ "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "species_114523" ] }, "reaction_10617893": { "compartment": "compartment_984", "id": "reaction_10617893", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10616744" ], "products": [ "species_10616748" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10662902": { "compartment": "compartment_876", "id": "reaction_10662902", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662899" ], "products": [ "species_10662895" ], "modifiers": [ [ "species_10662899", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10666056": { "compartment": "compartment_70101", "id": "reaction_10666056", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10617968": { "compartment": "compartment_984", "id": "reaction_10617968", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616790", "species_416911" ], "products": [ "species_10616792" ], "modifiers": [], "additional_components": [ "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_879629", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086" ] }, "reaction_10636281": { "compartment": "compartment_876", "id": "reaction_10636281", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636278" ], "products": [ "species_10630578" ], "modifiers": [ [ "species_10618504", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624788": { "compartment": "compartment_876", "id": "reaction_10624788", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616656", "species_10605486" ], "products": [ "species_10616658" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "species_205687", "CHEBI:15650", "species_266074", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "species_74016", "CHEBI:28875", "species_113552", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794" ] }, "reaction_10651371": { "compartment": "compartment_876", "id": "reaction_10651371", "reactome": "R-CEL-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10651368", "catalyst" ] ], "additional_components": [ "WBGene00011524" ] }, "reaction_10621741": { "compartment": "compartment_984", "id": "reaction_10621741", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10621737" ], "products": [ "species_10621739" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "G5ECX0", "WBGene00002252", "species_444761", "Q19930", "WBGene00017947" ] }, "reaction_10624997": { "compartment": "compartment_70101", "id": "reaction_10624997", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624992" ], "products": [ "species_10624988", "species_29420" ], "modifiers": [ [ "species_10624992", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618959": { "compartment": "compartment_984", "id": "reaction_10618959", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_417888" ], "products": [ "species_10616605" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_205687" ] }, "reaction_10663247": { "compartment": "compartment_876", "id": "reaction_10663247", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663242" ], "products": [ "species_10663229", "species_10605484" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_111349" ] }, "reaction_10618506": { "compartment": "compartment_876", "id": "reaction_10618506", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604943", "species_114519" ], "products": [ "species_10618504" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624961": { "compartment": "compartment_984", "id": "reaction_10624961", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616660" ], "products": [ "species_10605064", "species_10624953", "species_10624959", "species_10604843" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q95YD7", "WBGene00016265", "O62403", "WBGene00013782", "O44536", "WBGene00019224", "O18014", "WBGene00011381", "G5EBX8", "WBGene00008890", "A0A3B1DQQ4", "WBGene00006864", "O17239", "WBGene00019616", "Q09502", "WBGene00008065", "O44731", "WBGene00018798", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "Q23265", "WBGene00013871", "Q20841", "WBGene00018886", "Q09638", "WBGene00012084", "Q23497", "WBGene00013974", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "Q20325", "WBGene00018344", "H9G358", "WBGene00018089", "G5EDI0", "WBGene00007395", "A0A0K3AYF5", "C16D6.2b", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "A0A2C9C3A4", "WBGene00018089", "Q18130", "WBGene00016044", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q9XVS5", "WBGene00007614", "Q18701", "WBGene00016747", "A0A0K3AXD3", "WBGene00011372", "Q19399", "WBGene00008736", "Q03566", "WBGene00006576", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "P91096", "WBGene00016037", "Q23033", "WBGene00020086", "CHEBI:6498", "species_374935", "CHEBI:28364", "species_29370", "CHEBI:30772", "species_265287", "CHEBI:53460", "species_8869214", "species_2046056", "species_427486", "CHEBI:53487", "CHEBI:17120", "species_205687", "CHEBI:15650", "species_390899", "Q93518", "WBGene00008879", "species_216667", "CHEBI:50122", "species_113552", "CHEBI:30212", "species_29460", "CHEBI:28716", "species_29468", "CHEBI:42504", "species_264643", "species_2066763", "species_8934421", "species_390435", "species_879535", "species_29444", "CHEBI:15627", "species_209849", "CHEBI:30768", "species_266074", "CHEBI:30805", "CHEBI:16196", "Q10651", "WBGene00000149", "species_74016", "CHEBI:28875", "species_70106", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "species_113585", "CHEBI:27997", "species_113592", "CHEBI:31011", "species_266056", "species_209794", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618957": { "compartment": "compartment_984", "id": "reaction_10618957", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10616766" ], "products": [ "species_10616768" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10618961": { "compartment": "compartment_984", "id": "reaction_10618961", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616447", "species_83908" ], "products": [ "species_10616449" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10665053": { "compartment": "compartment_70101", "id": "reaction_10665053", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10665050", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10605432": { "compartment": "compartment_70101", "id": "reaction_10605432", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10605429", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10615432": { "compartment": "compartment_984", "id": "reaction_10615432", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615428", "species_210382" ], "products": [ "species_10615430" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "species_113552", "Q09630", "WBGene00003232" ] }, "reaction_10617972": { "compartment": "compartment_984", "id": "reaction_10617972", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616631", "species_416436" ], "products": [ "species_10616633" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "species_266056", "Q9XVS5", "WBGene00007614" ] }, "reaction_10664924": { "compartment": "compartment_984", "id": "reaction_10664924", "reactome": "R-CEL-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615597", "species_9615246" ], "products": [ "species_10664922" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=587", "LigandDisplayForward?ligandId=592", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590", "LigandDisplayForward?ligandId=587", "Q09638", "WBGene00012084", "LigandDisplayForward?ligandId=592", "O18014", "WBGene00011381", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590" ] }, "reaction_10617895": { "compartment": "compartment_984", "id": "reaction_10617895", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10616718" ], "products": [ "species_10616720" ], "modifiers": [], "additional_components": [ "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506", "species_380873", "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506" ] }, "reaction_10618573": { "compartment": "compartment_876", "id": "reaction_10618573", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604843" ], "products": [ "species_10618571" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "Q09639", "WBGene00001709", "species_29438" ] }, "reaction_10605434": { "compartment": "compartment_70101", "id": "reaction_10605434", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605415", "species_10605427" ], "products": [ "species_10605429" ], "modifiers": [], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10616856": { "compartment": "compartment_947587", "id": "reaction_10616856", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616842" ], "products": [ "species_29420", "species_10616846" ], "modifiers": [ [ "species_10616842", "catalyst" ], [ "species_10616852", "inhibitor" ] ], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "WBGene00000092" ] }, "reaction_10617897": { "compartment": "compartment_984", "id": "reaction_10617897", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616704" ], "products": [ "species_10616706" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10616667": { "compartment": "compartment_70101", "id": "reaction_10616667", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616658" ], "products": [ "species_10616660", "species_29420" ], "modifiers": [ [ "species_10616664", "catalyst" ] ], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10662889": { "compartment": "compartment_70101", "id": "reaction_10662889", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662884" ], "products": [ "species_10607663", "species_10662882" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "WBGene00005077" ] }, "reaction_10617899": { "compartment": "compartment_984", "id": "reaction_10617899", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616392" ], "products": [ "species_10616394" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10624984": { "compartment": "compartment_876", "id": "reaction_10624984", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605484", "species_10605064" ], "products": [ "species_10605486" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_111349", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618928": { "compartment": "compartment_876", "id": "reaction_10618928", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843" ], "products": [ "species_10605484" ], "modifiers": [ [ "species_10604843", "catalyst" ], [ "species_10618926", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "species_111349", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10624980": { "compartment": "compartment_984", "id": "reaction_10624980", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616846" ], "products": [ "species_10607663", "species_10605064", "species_10616838" ], "modifiers": [], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086" ] }, "reaction_10621705": { "compartment": "compartment_984", "id": "reaction_10621705", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10616641" ], "products": [ "species_10616645" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10625140": { "compartment": "compartment_876", "id": "reaction_10625140", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621723", "species_10625136" ], "products": [ "species_10625138" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q18849", "WBGene00008314", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "Q19930", "WBGene00017947" ] }, "reaction_10617970": { "compartment": "compartment_984", "id": "reaction_10617970", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_416372" ], "products": [ "species_10616770" ], "modifiers": [], "additional_components": [ "WBGene00016570", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "H2KZ99", "WBGene00016570" ] }, "reaction_10624978": { "compartment": "compartment_70101", "id": "reaction_10624978", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624969" ], "products": [ "species_10624975", "species_29420" ], "modifiers": [ [ "species_10624969", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_29438", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618852": { "compartment": "compartment_876", "id": "reaction_10618852", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618112" ], "products": [ "species_10618849" ], "modifiers": [ [ "species_10618112", "catalyst" ] ], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "species_111349", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674" ] }, "reaction_10617962": { "compartment": "compartment_984", "id": "reaction_10617962", "reactome": "R-CEL-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616424", "species_10616415" ], "products": [ "species_10616426" ], "modifiers": [], "additional_components": [ "Q21013", "WBGene00001466", "A7DT38", "WBGene00020722", "WBGene00008239", "Q21013", "WBGene00001466", "L8EC40", "WBGene00008239", "A7DT38", "WBGene00020722" ] }, "reaction_10618729": { "compartment": "compartment_984", "id": "reaction_10618729", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616552", "species_417891" ], "products": [ "species_10616554" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10618847": { "compartment": "compartment_70101", "id": "reaction_10618847", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10618844", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "O18696", "WBGene00011433", "Q9N2V9", "WBGene00022389", "P91119", "WBGene00016328" ] }, "reaction_10617901": { "compartment": "compartment_984", "id": "reaction_10617901", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616700", "species_114523" ], "products": [ "species_10616702" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10665554": { "compartment": "compartment_984", "id": "reaction_10665554", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665550", "species_380873" ], "products": [ "species_10665552" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_380873", "Q6RYS9", "WBGene00020506" ] }, "reaction_10617889": { "compartment": "compartment_984", "id": "reaction_10617889", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616508", "species_372533" ], "products": [ "species_10616514" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10618733": { "compartment": "compartment_984", "id": "reaction_10618733", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616548", "species_417891" ], "products": [ "species_10616550" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662897": { "compartment": "compartment_876", "id": "reaction_10662897", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10608724", "species_10613387", "species_10605064", "species_10617723" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "WBGene00010776", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "WBGene00003911" ] }, "reaction_10617974": { "compartment": "compartment_984", "id": "reaction_10617974", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616599", "species_416372" ], "products": [ "species_10616601" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "Q23265", "WBGene00013871", "CHEBI:15650", "species_266074", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10617903": { "compartment": "compartment_984", "id": "reaction_10617903", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616544", "species_114523" ], "products": [ "species_10616546" ], "modifiers": [], "additional_components": [ "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "species_114523" ] }, "reaction_10665773": { "compartment": "compartment_984", "id": "reaction_10665773", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_9684615" ], "products": [ "species_10665771" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=3634", "LigandDisplayForward?ligandId=5861", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10665777": { "compartment": "compartment_984", "id": "reaction_10665777", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_416372" ], "products": [ "species_10616587" ], "modifiers": [ [ "species_10665771", "inhibitor" ] ], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10605534": { "compartment": "compartment_876", "id": "reaction_10605534", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605529" ], "products": [ "species_10605531" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "species_179856", "species_114520", "G5EGU1", "WBGene00001196", "species_114519", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10663233": { "compartment": "compartment_876", "id": "reaction_10663233", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663229", "species_10604843" ], "products": [ "species_10663231" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10662887": { "compartment": "compartment_876", "id": "reaction_10662887", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10662879" ], "products": [ "species_29370", "species_10662884" ], "modifiers": [ [ "species_10662879", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665804": { "compartment": "compartment_984", "id": "reaction_10665804", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10665800" ], "products": [ "species_10665802" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10617640": { "compartment": "compartment_984", "id": "reaction_10617640", "reactome": "R-CEL-389463", "name": "Proteinase-activated receptors can bind thrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616635", "species_10605556" ], "products": [ "species_10616639" ], "modifiers": [], "additional_components": [ "WBGene00016570", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "species_74016" ] }, "reaction_10618989": { "compartment": "compartment_70101", "id": "reaction_10618989", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10662908": { "compartment": "compartment_70101", "id": "reaction_10662908", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10617723" ], "products": [ "species_10662891" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003911", "Q21430", "WBGene00010776", "Q17850", "WBGene00003911" ] }, "reaction_10662910": { "compartment": "compartment_876", "id": "reaction_10662910", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608722", "species_10662893" ], "products": [ "species_10662899" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10663227": { "compartment": "compartment_876", "id": "reaction_10663227", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663225" ], "products": [ "species_10663223", "species_10607683" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678" ] }, "reaction_10664441": { "compartment": "compartment_70101", "id": "reaction_10664441", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838", "species_10612150" ], "products": [ "species_10664439" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "WBGene00021022", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10663245": { "compartment": "compartment_876", "id": "reaction_10663245", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663231" ], "products": [ "species_10663242", "species_29372" ], "modifiers": [ [ "species_10663231", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10621703": { "compartment": "compartment_984", "id": "reaction_10621703", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10616457" ], "products": [ "species_10616459" ], "modifiers": [], "additional_components": [ "CHEBI:16755", "species_176655", "species_5357505", "species_193451", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "CHEBI:16755", "species_176655", "species_5357505", "Q19779", "WBGene00017779", "species_193451", "Q19295", "WBGene00017338" ] }, "reaction_10619074": { "compartment": "compartment_876", "id": "reaction_10619074", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10616834" ], "products": [ "species_10616836" ], "modifiers": [], "additional_components": [ "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10624994": { "compartment": "compartment_876", "id": "reaction_10624994", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605451", "species_10616523" ], "products": [ "species_10624992" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618118": { "compartment": "compartment_70101", "id": "reaction_10618118", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613395", "species_10618112" ], "products": [ "species_10618116" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663240": { "compartment": "compartment_876", "id": "reaction_10663240", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663235" ], "products": [ "species_10663225", "species_29372" ], "modifiers": [ [ "species_10663235", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665930": { "compartment": "compartment_984", "id": "reaction_10665930", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665926", "species_114523" ], "products": [ "species_10665928" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10618047": { "compartment": "compartment_70101", "id": "reaction_10618047", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10618044", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618122": { "compartment": "compartment_876", "id": "reaction_10618122", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618116", "species_10615544" ], "products": [ "species_10618120" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663237": { "compartment": "compartment_876", "id": "reaction_10663237", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663223", "species_10607663" ], "products": [ "species_10663235" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10616503": { "compartment": "compartment_70101", "id": "reaction_10616503", "reactome": "R-CEL-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616494" ], "products": [ "species_10616500", "species_29420" ], "modifiers": [ [ "species_10616494", "catalyst" ] ], "additional_components": [ "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_29438", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183" ] }, "reaction_10624990": { "compartment": "compartment_984", "id": "reaction_10624990", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624988" ], "products": [ "species_10618112", "species_791498", "species_10616519", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_374935", "species_209794", "CHEBI:15627", "WBGene00008890", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618731": { "compartment": "compartment_984", "id": "reaction_10618731", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616556", "species_417891" ], "products": [ "species_10616558" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662904": { "compartment": "compartment_70101", "id": "reaction_10662904", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662891", "species_10605064" ], "products": [ "species_10662893" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10647117": { "compartment": "compartment_70101", "id": "reaction_10647117", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646873" ], "products": [ "species_29370", "species_10647115" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10647434": { "compartment": "compartment_70101", "id": "reaction_10647434", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647395", "species_10647430" ], "products": [ "species_10647432" ], "modifiers": [], "additional_components": [ "WBGene00002982", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647477": { "compartment": "compartment_70101", "id": "reaction_10647477", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647430", "species_10647369" ], "products": [ "species_10647441" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882" ] }, "reaction_10647419": { "compartment": "compartment_70101", "id": "reaction_10647419", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647417" ], "products": [ "species_10646885", "species_29370" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647288": { "compartment": "compartment_70101", "id": "reaction_10647288", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646856", "species_113592" ], "products": [ "species_29370", "species_10647285" ], "modifiers": [ [ "species_10646856", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646893": { "compartment": "compartment_17938", "id": "reaction_10646893", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10646897": { "compartment": "compartment_70101", "id": "reaction_10646897", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10606957" ], "products": [ "species_10646861" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647615": { "compartment": "compartment_70101", "id": "reaction_10647615", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647445" ], "products": [ "species_10647430", "species_10647377" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922" ] }, "reaction_10647545": { "compartment": "compartment_12045", "id": "reaction_10647545", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646885" ], "products": [ "species_10647536" ], "modifiers": [ [ "species_10647541", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "WBGene00020706" ] }, "reaction_10646859": { "compartment": "compartment_70101", "id": "reaction_10646859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646624", "species_113592" ], "products": [ "species_29370", "species_10646856" ], "modifiers": [ [ "species_10646624", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646627": { "compartment": "compartment_70101", "id": "reaction_10646627", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646614" ], "products": [ "species_29370", "species_10646624" ], "modifiers": [ [ "species_10646614", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647428": { "compartment": "compartment_70101", "id": "reaction_10647428", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632839" ], "products": [ "species_10647417" ], "modifiers": [], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10632894": { "compartment": "compartment_70101", "id": "reaction_10632894", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10632841" ], "products": [ "species_29370", "species_10632847" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q23669", "WBGene00014151", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647448": { "compartment": "compartment_70101", "id": "reaction_10647448", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647443" ], "products": [ "species_10647445" ], "modifiers": [ [ "species_10647443", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10647409": { "compartment": "compartment_70101", "id": "reaction_10647409", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647377", "species_5681998" ], "products": [ "species_10647379", "species_10647381" ], "modifiers": [ [ "species_10647406", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "WBGene00021922", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10647424": { "compartment": "compartment_70101", "id": "reaction_10647424", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647285" ], "products": [ "species_10632891" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646878": { "compartment": "compartment_70101", "id": "reaction_10646878", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10617093" ], "products": [ "species_10646614" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647475": { "compartment": "compartment_70101", "id": "reaction_10647475", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647456" ], "products": [ "species_10647369" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647422": { "compartment": "compartment_70101", "id": "reaction_10647422", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10633217", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10664110": { "compartment": "compartment_70101", "id": "reaction_10664110", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647432" ], "products": [ "species_10647611" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647532": { "compartment": "compartment_70101", "id": "reaction_10647532", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647369", "species_5681998" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647613": { "compartment": "compartment_70101", "id": "reaction_10647613", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647381", "species_10647441" ], "products": [ "species_10647443" ], "modifiers": [], "additional_components": [ "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10646888": { "compartment": "compartment_12045", "id": "reaction_10646888", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10646885", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10647276": { "compartment": "compartment_74700", "id": "reaction_10647276", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647115" ], "products": [ "species_10606979", "species_10646871" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10647565": { "compartment": "compartment_5683628", "id": "reaction_10647565", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647556" ], "modifiers": [ [ "species_10647563", "catalyst" ], [ "species_10625721", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "A7DT33", "WBGene00021319", "Q9TXI7", "WBGene00006932", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216" ] }, "reaction_10647681": { "compartment": "compartment_70101", "id": "reaction_10647681", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646871" ], "products": [ "species_10646612", "species_29372" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10646876": { "compartment": "compartment_17938", "id": "reaction_10646876", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646861", "species_113592" ], "products": [ "species_29370", "species_10646873" ], "modifiers": [ [ "species_10646861", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647313": { "compartment": "compartment_70101", "id": "reaction_10647313", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647309", "species_5693050" ], "products": [ "species_10647311" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641", "species_1806200", "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641" ] }, "reaction_10647426": { "compartment": "compartment_70101", "id": "reaction_10647426", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647404", "species_10647402" ], "products": [ "species_10647406" ], "modifiers": [], "additional_components": [ "species_5334668", "O16466", "WBGene00018294", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q09406", "WBGene00019427", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10655850": { "compartment": "compartment_6791047", "id": "reaction_10655850", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10649186", "species_10655846" ], "products": [ "species_10655848" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713" ] }, "reaction_10655917": { "compartment": "compartment_6791047", "id": "reaction_10655917", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655913", "species_10655868" ], "products": [ "species_10655915" ], "modifiers": [], "additional_components": [ "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EGG0", "WBGene00010713" ] }, "reaction_10655871": { "compartment": "compartment_6791047", "id": "reaction_10655871", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10655864" ], "products": [ "species_29370", "species_10655868" ], "modifiers": [ [ "species_10655864", "catalyst" ] ], "additional_components": [ "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183" ] }, "reaction_10656339": { "compartment": "compartment_20699", "id": "reaction_10656339", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656335" ], "products": [ "species_10656337" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10656333": { "compartment": "compartment_20699", "id": "reaction_10656333", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656329", "species_10656314" ], "products": [ "species_10656331" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q95ZW1", "WBGene00017273", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20797", "WBGene00006373", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855" ] }, "reaction_10656176": { "compartment": "compartment_432051", "id": "reaction_10656176", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656172", "species_10656090" ], "products": [ "species_10656174" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "Q21408", "WBGene00004951", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q22328", "WBGene00002976", "G5EGG0", "WBGene00010713", "G5EFW3", "WBGene00004855", "Q09473", "WBGene00016195", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "G5EDD4", "WBGene00006530", "Q09236", "WBGene00015734", "G5EEU1", "WBGene00043064", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "G5EGG0", "WBGene00010713", "Q19020", "WBGene00000962", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "Q22328", "WBGene00002976", "G5EF01", "WBGene00006539", "G5EFW3", "WBGene00004855", "Q9NA98", "WBGene00013168", "O18154", "WBGene00006533", "O45087", "WBGene00015927", "Q9UAQ6", "WBGene00004266", "Q21408", "WBGene00004951", "species_29420", "Q18194", "WBGene00016124", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "P52275", "WBGene00006537", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9GYR2", "WBGene00016793", "species_29438", "Q9TXZ9", "WBGene00015164", "P12456", "WBGene00003171", "O62246", "WBGene00009732", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "P34685", "WBGene00000292", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "O17921", "WBGene00006536", "A0AAC1", "WBGene00012424" ] }, "reaction_10621209": { "compartment": "compartment_17906", "id": "reaction_10621209", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_200993" ], "modifiers": [ [ "species_10621206", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10650696": { "compartment": "compartment_7660", "id": "reaction_10650696", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650680" ], "products": [ "species_10650618" ], "modifiers": [ [ "species_10650605", "catalyst" ], [ "species_10650694", "catalyst" ], [ "species_10650610", "catalyst" ], [ "species_10650678", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "WBGene00012393", "Q95Y89", "WBGene00003063", "Q21086", "WBGene00003821", "Q09958", "WBGene00015941", "WBGene00010709", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893" ] }, "reaction_10650964": { "compartment": "compartment_7660", "id": "reaction_10650964", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650929" ], "products": [ "species_10650937" ], "modifiers": [ [ "species_10650961", "catalyst" ], [ "species_10650949", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "Q93830", "WBGene00010325", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "Q23223", "WBGene00012342", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "O16207", "WBGene00017916", "Q9N4P9", "WBGene00000202", "Q9XXD2", "WBGene00012966", "WBGene00000798", "WBGene00012342", "WBGene00000796" ] }, "reaction_10650652": { "compartment": "compartment_7660", "id": "reaction_10650652", "reactome": "R-CEL-6791218", "name": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650618" ], "products": [ "species_10601533" ], "modifiers": [ [ "species_10650645", "catalyst" ], [ "species_10650650", "catalyst" ], [ "species_10650623", "catalyst" ], [ "species_10650635", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ], [ "species_10650630", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00001332", "WBGene00012465", "WBGene00021785", "WBGene00017916", "WBGene00012342", "WBGene00000796", "WBGene00001001" ] }, "reaction_10651116": { "compartment": "compartment_7660", "id": "reaction_10651116", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651102" ], "products": [ "species_10651106" ], "modifiers": [ [ "species_10651111", "catalyst" ], [ "species_10650818", "catalyst" ], [ "species_10650794", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10651114", "catalyst" ], [ "species_10650772", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "WBGene00006964", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q95XY4", "WBGene00021789", "WBGene00015104", "WBGene00012342", "WBGene00004705", "A7DT40", "WBGene00045433", "Q9XUU8", "WBGene00010582", "Q9N477", "WBGene00021276", "Q23495", "WBGene00022739" ] }, "reaction_10663299": { "compartment": "compartment_70101", "id": "reaction_10663299", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663271" ], "products": [ "species_10663297" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663273": { "compartment": "compartment_70101", "id": "reaction_10663273", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263", "species_10663269" ], "products": [ "species_10663271" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10630255": { "compartment": "compartment_7660", "id": "reaction_10630255", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10628778" ], "products": [ "species_10630253" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00003020", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10665597": { "compartment": "compartment_70101", "id": "reaction_10665597", "reactome": "R-CEL-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665595" ], "products": [ "species_10598308" ], "modifiers": [], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10630260": { "compartment": "compartment_7660", "id": "reaction_10630260", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630253", "species_10597874" ], "products": [ "species_10630257", "species_10609440" ], "modifiers": [ [ "species_10630253", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "G5EDT1", "WBGene00003020", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10630229": { "compartment": "compartment_7660", "id": "reaction_10630229", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628790" ], "products": [ "species_113550", "species_10628782" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10630231": { "compartment": "compartment_7660", "id": "reaction_10630231", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628778" ], "products": [ "species_113550", "species_10628748" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10628604": { "compartment": "compartment_12045", "id": "reaction_10628604", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628597" ], "products": [ "species_74016", "species_10628599" ], "modifiers": [ [ "species_10628601", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "species_74016", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10635753": { "compartment": "compartment_12045", "id": "reaction_10635753", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635749", "species_10628599" ], "products": [ "species_10635751" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10635700": { "compartment": "compartment_876", "id": "reaction_10635700", "reactome": "R-CEL-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10635697", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q45FX5", "WBGene00006887", "G5EDP9", "WBGene00000001" ] }, "reaction_10635756": { "compartment": "compartment_70101", "id": "reaction_10635756", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10635751", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10611606": { "compartment": "compartment_876", "id": "reaction_10611606", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611656": { "compartment": "compartment_876", "id": "reaction_10611656", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611652": { "compartment": "compartment_70101", "id": "reaction_10611652", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10656006": { "compartment": "compartment_5460", "id": "reaction_10656006", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10656003", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10656014": { "compartment": "compartment_70101", "id": "reaction_10656014", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10656011", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10611619": { "compartment": "compartment_876", "id": "reaction_10611619", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10611616", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10611640": { "compartment": "compartment_70616", "id": "reaction_10611640", "reactome": "R-CEL-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10611637", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10611658": { "compartment": "compartment_70101", "id": "reaction_10611658", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611608": { "compartment": "compartment_70101", "id": "reaction_10611608", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611650": { "compartment": "compartment_70101", "id": "reaction_10611650", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611660": { "compartment": "compartment_70101", "id": "reaction_10611660", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10655553": { "compartment": "compartment_70101", "id": "reaction_10655553", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_70106", "species_29370", "species_200640", "species_29372" ], "modifiers": [ [ "species_10655550", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10655555": { "compartment": "compartment_5460", "id": "reaction_10655555", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611581": { "compartment": "compartment_70101", "id": "reaction_10611581", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10649581": { "compartment": "compartment_5460", "id": "reaction_10649581", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611632": { "compartment": "compartment_70101", "id": "reaction_10611632", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10611629", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10666081": { "compartment": "compartment_70101", "id": "reaction_10666081", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10666078", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10610864": { "compartment": "compartment_70101", "id": "reaction_10610864", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10611642": { "compartment": "compartment_70101", "id": "reaction_10611642", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10610862": { "compartment": "compartment_70101", "id": "reaction_10610862", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10610854": { "compartment": "compartment_70101", "id": "reaction_10610854", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611647": { "compartment": "compartment_5460", "id": "reaction_10611647", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10611644", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611622": { "compartment": "compartment_70101", "id": "reaction_10611622", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10602950": { "compartment": "compartment_7660", "id": "reaction_10602950", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602938" ], "products": [ "species_10602946" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602940": { "compartment": "compartment_7660", "id": "reaction_10602940", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602934" ], "products": [ "species_10602938" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602948": { "compartment": "compartment_7660", "id": "reaction_10602948", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602946" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10661007": { "compartment": "compartment_7660", "id": "reaction_10661007", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661003", "species_10658637" ], "products": [ "species_10661005" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "H2KYY1", "WBGene00016029", "G5EFQ5", "WBGene00004393" ] }, "reaction_10650030": { "compartment": "compartment_70101", "id": "reaction_10650030", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646645", "species_10650024" ], "products": [ "species_10650028" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10650026": { "compartment": "compartment_70101", "id": "reaction_10650026", "reactome": "R-CEL-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10650022" ], "products": [ "species_10650024" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00016500", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10656931": { "compartment": "compartment_70101", "id": "reaction_10656931", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656927", "species_10617956" ], "products": [ "species_10656929" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q20636", "WBGene00001680", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656937": { "compartment": "compartment_70101", "id": "reaction_10656937", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656935" ], "products": [ "species_10656929", "species_29372" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657582": { "compartment": "compartment_70101", "id": "reaction_10657582", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657580" ], "products": [ "species_10657558", "species_10656946" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142" ] }, "reaction_10657586": { "compartment": "compartment_70101", "id": "reaction_10657586", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657576" ], "products": [ "species_10657584", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10617960": { "compartment": "compartment_70101", "id": "reaction_10617960", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617912", "species_10617956" ], "products": [ "species_10617958" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q18425", "WBGene00007918", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656989": { "compartment": "compartment_70101", "id": "reaction_10656989", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656983", "species_10605048" ], "products": [ "species_10656987" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681" ] }, "reaction_10657556": { "compartment": "compartment_70101", "id": "reaction_10657556", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657554" ], "products": [ "species_10656983", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656981": { "compartment": "compartment_70101", "id": "reaction_10656981", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656979" ], "products": [ "species_29370", "species_10656946" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10656952": { "compartment": "compartment_70101", "id": "reaction_10656952", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_113592" ], "products": [ "species_29370", "species_10656935" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656950": { "compartment": "compartment_70101", "id": "reaction_10656950", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_10656946" ], "products": [ "species_10656948" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142", "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657590": { "compartment": "compartment_70101", "id": "reaction_10657590", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656987", "species_10604837" ], "products": [ "species_10657588", "species_10656946" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10657578": { "compartment": "compartment_70101", "id": "reaction_10657578", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657558", "species_10657574" ], "products": [ "species_10657576" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391" ] }, "reaction_10621270": { "compartment": "compartment_1462052", "id": "reaction_10621270", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621267", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10621299": { "compartment": "compartment_876", "id": "reaction_10621299", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10621296", "catalyst" ] ], "additional_components": [ "WBGene00017954" ] }, "reaction_10621278": { "compartment": "compartment_20699", "id": "reaction_10621278", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621275", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10621262": { "compartment": "compartment_876", "id": "reaction_10621262", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10621259", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621430": { "compartment": "compartment_876", "id": "reaction_10621430", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621427", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10621438": { "compartment": "compartment_12045", "id": "reaction_10621438", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621435", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10621254": { "compartment": "compartment_876", "id": "reaction_10621254", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10621251", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10662865": { "compartment": "compartment_70101", "id": "reaction_10662865", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10662862", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621286": { "compartment": "compartment_20699", "id": "reaction_10621286", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10621283", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10625287": { "compartment": "compartment_876", "id": "reaction_10625287", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10621419": { "compartment": "compartment_876", "id": "reaction_10621419", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10621507": { "compartment": "compartment_876", "id": "reaction_10621507", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10621504", "catalyst" ] ], "additional_components": [ "O44196", "WBGene00022682", "O02340", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10621483": { "compartment": "compartment_876", "id": "reaction_10621483", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621480", "catalyst" ] ], "additional_components": [ "P91348", "WBGene00018897", "Q9XWH3", "WBGene00013207", "O62192", "WBGene00009286", "Q22395", "WBGene00006486", "Q09957", "WBGene00015940", "Q6BEU0", "WBGene00014669", "U4PS08", "WBGene00021936", "Q19913", "WBGene00017936" ] }, "reaction_10621397": { "compartment": "compartment_876", "id": "reaction_10621397", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621394", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10606319": { "compartment": "compartment_13231", "id": "reaction_10606319", "reactome": "R-CEL-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604046" ], "products": [ "species_10606317" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10605966": { "compartment": "compartment_70101", "id": "reaction_10605966", "reactome": "R-CEL-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10605960" ], "products": [ "species_10602837", "species_10605964", "species_10602815" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00000122", "O61955", "WBGene00002061", "WBGene00003835", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600941": { "compartment": "compartment_7660", "id": "reaction_10600941", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600934" ], "products": [ "species_10600717", "species_10600755", "species_10600936", "species_10600767" ], "modifiers": [ [ "species_10600938", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q19864", "WBGene00000773", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q93716", "WBGene00009668", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "C1P629", "WBGene00008362", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93716", "WBGene00009668" ] }, "reaction_10602612": { "compartment": "compartment_7660", "id": "reaction_10602612", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602608" ], "products": [ "species_10602610", "species_10602600" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q9N5K2", "WBGene00019246", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916" ] }, "reaction_10602861": { "compartment": "compartment_70101", "id": "reaction_10602861", "reactome": "R-CEL-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602857" ], "products": [ "species_10602859", "species_10602825", "species_10602774" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "Q09601", "WBGene00003805", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q9XVS7", "WBGene00003834", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q86G90", "WBGene00003795", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "O01576", "WBGene00003797", "Q17561", "WBGene00000120", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "O62183", "WBGene00000121", "Q7K6X4", "WBGene00003802", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9BKT9", "WBGene00003799", "Q21155", "WBGene00004388", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "G5EEH9", "WBGene00003796", "Q9BL61", "WBGene00022029", "Q17561", "WBGene00000120", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q21832", "WBGene00004387", "O62183", "WBGene00000121", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600807": { "compartment": "compartment_7660", "id": "reaction_10600807", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600800" ], "products": [ "species_10600804", "species_10600794" ], "modifiers": [ [ "species_10600800", "catalyst" ] ], "additional_components": [ "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", 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"WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10605962": { "compartment": "compartment_13231", "id": "reaction_10605962", "reactome": "R-CEL-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604763" ], "products": [ "species_10605960" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600946": { "compartment": "compartment_7660", "id": "reaction_10600946", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600936" ], "products": [ "species_10600734", "species_10600943", "species_10600698", "species_10600739" ], "modifiers": [ [ "species_10600734", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10600830": { "compartment": "compartment_7660", "id": "reaction_10600830", "reactome": "R-CEL-72143", "name": "Lariat Formation and 5'-Splice Site Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600814", "species_10600804", "species_10600824", "species_10600812", "species_10600819" ], "products": [ "species_10600828" ], "modifiers": [], "additional_components": [ "WBGene00004705", "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", "Q19335", "WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", 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"P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q09385", "WBGene00019402", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q9U1Q3", "WBGene00000891", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10606328": { "compartment": "compartment_7660", "id": "reaction_10606328", "reactome": "R-CEL-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602797", "species_10600943" ], "products": [ "species_10606325", "species_113550", "species_10602803" ], "modifiers": [ [ "species_10600943", "catalyst" ] ], "additional_components": [ "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "species_29370", "Q18212", "WBGene00001840", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q9XVS7", "WBGene00003834", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "Q10667", "WBGene00004384", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384" ] }, "reaction_10604765": { "compartment": "compartment_7660", "id": "reaction_10604765", "reactome": "R-CEL-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600236", "species_10604757", "species_10602784" ], "products": [ "species_10604763", "species_10599886" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00003835", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600802": { "compartment": "compartment_7660", "id": "reaction_10600802", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600774", "species_10600769", "species_10600662", "species_10600794", "species_10600779", "species_10600789", "species_10600784" ], "products": [ "species_10600127", "species_10600591", "species_10600461", "species_10600586", "species_10600494", "species_10600800", "species_10600643", "species_10600533", "species_10600581" ], "modifiers": [], "additional_components": [ "WBGene00022029", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10021", "WBGene00004702", "Q9GRZ2", 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"Q9U2S6", "WBGene00000889", "Q8ITY4", "WBGene00016808", "Q22307", "WBGene00004355", "Q21322", "WBGene00004385", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "Q9XVS2", "WBGene00045383", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "Q9XUY1", "WBGene00010159", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "P91306", "WBGene00000473", "Q21739", "WBGene00011035", "Q9NLD1", "WBGene00002000", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "P91398", "WBGene00000474", "Q966L5", "WBGene00017085", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "P90815", "WBGene00017238", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9GR61", "WBGene00021347", "Q9XTZ2", "WBGene00004705", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O44787", "WBGene00017280", "Q9U1W8", "WBGene00003077", "P52018", "WBGene00000887", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q21486", "WBGene00010844", "O18694", "WBGene00003079", "Q20875", "WBGene00018967", "Q17336", "WBGene00002957", "Q93339", "WBGene00007972", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19952", "WBGene00003078", "Q95YF1", "WBGene00015581", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", 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"WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "Q9XXI7", "WBGene00000892", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", "Q95PY8", "WBGene00013460", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "Q966L5", "WBGene00017085", "P91398", "WBGene00000474", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776", "WBGene00008380", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "Q95XD4", "WBGene00003082", "O18694", "WBGene00003079", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "WBGene00017605" ] }, "reaction_10606323": { "compartment": "compartment_70101", "id": "reaction_10606323", "reactome": "R-CEL-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10606317" ], "products": [ "species_10602837", "species_10602815", "species_10606321" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "Q09599", "WBGene00000411", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10602614": { "compartment": "compartment_7660", "id": "reaction_10602614", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602610" ], "products": [ "species_10602610" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474" ] }, "reaction_10600948": { "compartment": "compartment_7660", "id": "reaction_10600948", "reactome": "R-CEL-72231", "name": "Formation of the Cleavage and Polyadenylation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10600755", "species_10600734", "species_10600767", "species_10600698", "species_10600739" ], "products": [ "species_10600769" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797" ] }, "reaction_10600664": { "compartment": "compartment_7660", "id": "reaction_10600664", "reactome": "R-CEL-72127", "name": "Formation of the Spliceosomal B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604042", "species_10600236", "species_10602784" ], "products": [ "species_10599879", "species_10599884", "species_10604046" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "WBGene00000122", "WBGene00003835", "WBGene00009141", "WBGene00018156", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10645511": { "compartment": "compartment_18730", "id": "reaction_10645511", "reactome": "R-CEL-5625421", "name": "The anterograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645507" ], "products": [ "species_10645492", "species_10645446", "species_10645410", "species_10645462", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10644779": { "compartment": "compartment_20699", "id": "reaction_10644779", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644777" ], "products": [ "species_10644775", "species_10644770" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10645519": { "compartment": "compartment_18730", "id": "reaction_10645519", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645496" ], "products": [ "species_10645515" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645509": { "compartment": "compartment_18730", "id": "reaction_10645509", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645390" ], "products": [ "species_10645507" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645392": { "compartment": "compartment_18730", "id": "reaction_10645392", "reactome": "R-CEL-5624949", "name": "Assembly of the anterograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645336", "species_10645291", "species_10645388", "species_10645216" ], "products": [ "species_10645390" ], "modifiers": [], "additional_components": [ "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P46873", "WBGene00003884", "P12456", "WBGene00003171", "Q19633", "WBGene00002222", "species_29420", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645498": { "compartment": "compartment_18730", "id": "reaction_10645498", "reactome": "R-CEL-5624952", "name": "Assembly of the retrograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645494", "species_10645446", "species_10645410", "species_10645462" ], "products": [ "species_10645496" ], "modifiers": [], "additional_components": [ "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "CHEBI:15996", "Q22799", "WBGene00001005", "P12456", "WBGene00003171", "species_29420", "Q22752", "WBGene00012004", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645517": { "compartment": "compartment_18730", "id": "reaction_10645517", "reactome": "R-CEL-5625424", "name": "The retrograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645515" ], "products": [ "species_10645336", "species_10645291", "species_10645216", "species_10645386", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10657713": { "compartment": "compartment_7660", "id": "reaction_10657713", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10657706", "species_10597874" ], "products": [ "species_10657711", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657810": { "compartment": "compartment_7660", "id": "reaction_10657810", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657770", "species_10657787" ], "products": [ "species_10657711", "species_10657808" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344" ] }, "reaction_10657815": { "compartment": "compartment_70101", "id": "reaction_10657815", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657717", "species_113592", "species_10597908" ], "products": [ "species_10657721", "species_111294" ], "modifiers": [ [ "species_10657717", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657812": { "compartment": "compartment_7660", "id": "reaction_10657812", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597874", "species_10657768" ], "products": [ "species_10657770", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657909": { "compartment": "compartment_70101", "id": "reaction_10657909", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657902" ], "products": [ "species_10601455", "species_10597908" ], "modifiers": [ [ "species_10657906", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00006727", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657821": { "compartment": "compartment_70101", "id": "reaction_10657821", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627924", "species_113592", "species_10597908" ], "products": [ "species_10657723", "species_111294" ], "modifiers": [ [ "species_10627924", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006699" ] }, "reaction_10657818": { "compartment": "compartment_70101", "id": "reaction_10657818", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657723" ], "products": [ "species_10657717", "species_76577" ], "modifiers": [ [ "species_10657723", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657823": { "compartment": "compartment_7660", "id": "reaction_10657823", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657711" ], "products": [ "species_164121", "species_10657768" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657766": { "compartment": "compartment_70101", "id": "reaction_10657766", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657715", "species_10657721" ], "products": [ "species_10657723", "species_10657764" ], "modifiers": [], "additional_components": [ "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10629119": { "compartment": "compartment_984", "id": "reaction_10629119", "reactome": "R-CEL-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10629164": { "compartment": "compartment_70101", "id": "reaction_10629164", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10630872": { "compartment": "compartment_70101", "id": "reaction_10630872", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10629166": { "compartment": "compartment_70101", "id": "reaction_10629166", "reactome": "R-CEL-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022", "species_425425" ], "products": [ "species_111627", "species_188972" ], "modifiers": [ [ "species_10629103", "catalyst" ] ], "additional_components": [ "Q58QG8", "WBGene00019844" ] }, "reaction_10660894": { "compartment": "compartment_70101", "id": "reaction_10660894", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660850" ], "products": [ "species_10660892" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10660852": { "compartment": "compartment_70101", "id": "reaction_10660852", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10660848" ], "products": [ "species_10660850" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10661709": { "compartment": "compartment_7660", "id": "reaction_10661709", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658641", "species_10635479" ], "products": [ "species_10661707" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748" ] }, "reaction_10661669": { "compartment": "compartment_7660", "id": "reaction_10661669", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639320", "species_10658641" ], "products": [ "species_10661667" ], "modifiers": [], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00004393", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393", "Q10666", "WBGene00004077" ] }, "reaction_10624784": { "compartment": "compartment_20699", "id": "reaction_10624784", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_744233", "species_113578" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10624776": { "compartment": "compartment_20699", "id": "reaction_10624776", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624779": { "compartment": "compartment_20699", "id": "reaction_10624779", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624768": { "compartment": "compartment_20699", "id": "reaction_10624768", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10624765", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10624732": { "compartment": "compartment_20699", "id": "reaction_10624732", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_109395", "species_727815" ], "modifiers": [ [ "species_10624729", "catalyst" ] ], "additional_components": [ "Q95X47", "WBGene00015038", "Q93890", "WBGene00005153", "O17106", "WBGene00019451", "G5EBK5", "WBGene00018414", "O01879", "WBGene00022577", "O02345", "WBGene00014139" ] }, "reaction_10624786": { "compartment": "compartment_20699", "id": "reaction_10624786", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_744229" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "species_914003", "species_29410", "species_914003", "species_29410", "WBGene00005025" ] }, "reaction_10624737": { "compartment": "compartment_20699", "id": "reaction_10624737", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10624734", "catalyst" ] ], "additional_components": [ "species_1981137", "species_735700", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10624760": { "compartment": "compartment_20699", "id": "reaction_10624760", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_109402", "species_914003" ], "modifiers": [ [ "species_10624757", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10604090": { "compartment": "compartment_7660", "id": "reaction_10604090", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10604083" ], "products": [ "species_10604087", "species_76230" ], "modifiers": [ [ "species_10604081", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604085": { "compartment": "compartment_7660", "id": "reaction_10604085", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10604081" ], "products": [ "species_10604083" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604745": { "compartment": "compartment_7660", "id": "reaction_10604745", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604079" ], "products": [ "species_10604081" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604520": { "compartment": "compartment_70101", "id": "reaction_10604520", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604487" ], "products": [ "species_29370", "species_10604517" ], "modifiers": [ [ "species_10604487", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10604524": { "compartment": "compartment_70101", "id": "reaction_10604524", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604517" ], "products": [ "species_10604483", "species_10604515" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10604489": { "compartment": "compartment_70101", "id": "reaction_10604489", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604483", "species_10604485" ], "products": [ "species_10604487" ], "modifiers": [], "additional_components": [ "WBGene00003186", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10599814": { "compartment": "compartment_70101", "id": "reaction_10599814", "reactome": "R-CEL-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10599811", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10622380": { "compartment": "compartment_5460", "id": "reaction_10622380", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10622377", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10666164": { "compartment": "compartment_876", "id": "reaction_10666164", "reactome": "R-CEL-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666158" ], "products": [ "species_10666162" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10646545": { "compartment": "compartment_876", "id": "reaction_10646545", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10608724" ], "products": [ "species_10646543" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "O62422", "WBGene00012532" ] }, "reaction_10640507": { "compartment": "compartment_70101", "id": "reaction_10640507", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640503", "species_10640499" ], "products": [ "species_10640505" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_109496", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "D6VPA1", "WBGene00018976", "Q22038", "WBGene00004357", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438", "species_109496" ] }, "reaction_10663659": { "compartment": "compartment_876", "id": "reaction_10663659", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663655", "species_10605408" ], "products": [ "species_10663657" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10665864": { "compartment": "compartment_17906", "id": "reaction_10665864", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665860", "species_10665854" ], "products": [ "species_10665862" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q19848", "WBGene00017895", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "G5EFU0", "WBGene00006443", "species_29438", "Q19848", "WBGene00017895" ] }, "reaction_10665798": { "compartment": "compartment_876", "id": "reaction_10665798", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724" ], "products": [ "species_10665796" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10665839": { "compartment": "compartment_876", "id": "reaction_10665839", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665835", "species_10665808" ], "products": [ "species_10665837" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064" ] }, "reaction_10665924": { "compartment": "compartment_876", "id": "reaction_10665924", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10665808" ], "products": [ "species_29372", "species_10665806" ], "modifiers": [ [ "species_10665921", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "P34288", "WBGene00015418", "Q19370", "WBGene00006406", "Q21341", "WBGene00002368", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10663798": { "compartment": "compartment_876", "id": "reaction_10663798", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10635280" ], "products": [ "species_10663796" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356" ] }, "reaction_10646773": { "compartment": "compartment_70101", "id": "reaction_10646773", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646765" ], "products": [ "species_29370", "species_10646770" ], "modifiers": [ [ "species_10618297", "catalyst" ] ], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00003911" ] }, "reaction_10663794": { "compartment": "compartment_876", "id": "reaction_10663794", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663790", "species_10605399" ], "products": [ "species_10663792" ], "modifiers": [], "additional_components": [ "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532", "Q03206", "ced-10", "species_29438", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "species_29438", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532" ] }, "reaction_10665790": { "compartment": "compartment_876", "id": "reaction_10665790", "reactome": "R-CEL-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828" ], "products": [ "species_10646655" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646685": { "compartment": "compartment_70101", "id": "reaction_10646685", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070", "species_10646679" ], "products": [ "species_10646683" ], "modifiers": [], "additional_components": [ "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438", "G5EE56", "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645649": { "compartment": "compartment_876", "id": "reaction_10645649", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10612107" ], "products": [ "species_10645644" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10645640": { "compartment": "compartment_70101", "id": "reaction_10645640", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645636", "species_10617721" ], "products": [ "species_10645638" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10636358": { "compartment": "compartment_70101", "id": "reaction_10636358", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635378" ], "products": [ "species_10635374", "species_10635408" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "species_179838", "species_29438", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q05062", "WBGene00000390", "Q10929", "WBGene00015146", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "species_179856", "O62422", "WBGene00012532", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10663835": { "compartment": "compartment_876", "id": "reaction_10663835", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663829", "species_10663831" ], "products": [ "species_10663833" ], "modifiers": [], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "species_29420", "Q05062", "WBGene00000390", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "O62422", "WBGene00012532" ] }, "reaction_10663622": { "compartment": "compartment_876", "id": "reaction_10663622", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10645591": { "compartment": "compartment_7660", "id": "reaction_10645591", "reactome": "R-CEL-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645574", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10645588" ], "modifiers": [ [ "species_10645574", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10663868": { "compartment": "compartment_876", "id": "reaction_10663868", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10663860" ], "products": [ "species_29372", "species_10663856" ], "modifiers": [ [ "species_10663865", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "P34288", "WBGene00015418", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10635410": { "compartment": "compartment_70101", "id": "reaction_10635410", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10635408" ], "products": [ "species_10633825" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "species_113592", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10635825": { "compartment": "compartment_876", "id": "reaction_10635825", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635822" ], "products": [ "species_29370", "species_10635372" ], "modifiers": [ [ "species_10616051", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "WBGene00000018" ] }, "reaction_10665794": { "compartment": "compartment_876", "id": "reaction_10665794", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399" ], "products": [ "species_10665792" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438" ] }, "reaction_10663685": { "compartment": "compartment_70101", "id": "reaction_10663685", "reactome": "R-CEL-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663681", "species_10646828" ], "products": [ "species_10663683" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "P92199", "WBGene00002694", "Q93332", "WBGene00007954", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "O02495", "WBGene00004897", "A0A4V0IKG6", "WBGene00007287", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q09994", "WBGene00019608", "Q17777", "WBGene00007409", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646783": { "compartment": "compartment_70101", "id": "reaction_10646783", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618297", "species_10646779" ], "products": [ "species_10646781" ], "modifiers": [], "additional_components": [ "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10646707": { "compartment": "compartment_70101", "id": "reaction_10646707", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10646703" ], "products": [ "species_10646705" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00016678", "Q22038", "WBGene00004357", "Q09506", "WBGene00016678", "Q17777", "WBGene00007409", "species_29438" ] }, "reaction_10663135": { "compartment": "compartment_70101", "id": "reaction_10663135", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617736", "species_10617721" ], "products": [ "species_10617734", "species_10645758" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10646791": { "compartment": "compartment_70101", "id": "reaction_10646791", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646781" ], "products": [ "species_29370", "species_10618297", "species_10646788" ], "modifiers": [ [ "species_10646781", "catalyst" ] ], "additional_components": [ "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10663863": { "compartment": "compartment_876", "id": "reaction_10663863", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663856" ], "products": [ "species_29420", "species_10663860" ], "modifiers": [ [ "species_10663856", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10663687": { "compartment": "compartment_70101", "id": "reaction_10663687", "reactome": "R-CEL-9013108", "name": "GDIs block activation of RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10646812": { "compartment": "compartment_70101", "id": "reaction_10646812", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646765", "species_10646805" ], "products": [ "species_10646810" ], "modifiers": [], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00010109", "Q7YX00", "WBGene00010109", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10663965": { "compartment": "compartment_876", "id": "reaction_10663965", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663957" ], "products": [ "species_10663959" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10664030": { "compartment": "compartment_876", "id": "reaction_10664030", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664027" ], "products": [ "species_10664007", "species_29420" ], "modifiers": [ [ "species_10664027", "catalyst" ] ], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10665788": { "compartment": "compartment_74700", "id": "reaction_10665788", "reactome": "R-CEL-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10665784" ], "products": [ "species_10665786" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10664025": { "compartment": "compartment_876", "id": "reaction_10664025", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664007", "species_10664021" ], "products": [ "species_10664023" ], "modifiers": [], "additional_components": [ "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10646777": { "compartment": "compartment_70101", "id": "reaction_10646777", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10635289" ], "products": [ "species_10646775" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "WBGene00003593", "H2KYX3", "WBGene00003593", "Q17850", "WBGene00003911" ] }, "reaction_10645608": { "compartment": "compartment_7660", "id": "reaction_10645608", "reactome": "R-CEL-5625870", "name": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10645588" ], "products": [ "species_159942", "species_159939", "species_10645605", "species_29478", "species_10628328" ], "modifiers": [ [ "species_10645588", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10665811": { "compartment": "compartment_876", "id": "reaction_10665811", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665806" ], "products": [ "species_10665808", "species_29420" ], "modifiers": [ [ "species_10665806", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10663849": { "compartment": "compartment_876", "id": "reaction_10663849", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724", "species_29356" ], "products": [ "species_10663829", "species_29372" ], "modifiers": [ [ "species_10663846", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10645560": { "compartment": "compartment_7660", "id": "reaction_10645560", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10645540" ], "products": [ "species_113582", "species_10645557" ], "modifiers": [ [ "species_10645540", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10651401": { "compartment": "compartment_1222693", "id": "reaction_10651401", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10651398", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10663703": { "compartment": "compartment_876", "id": "reaction_10663703", "reactome": "R-CEL-9013111", "name": "RHOC GAPs stimulate RHOC GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663700", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q9XUS9", "WBGene00000875", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10664051": { "compartment": "compartment_876", "id": "reaction_10664051", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664049" ], "products": [ "species_10664034", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059" ] }, "reaction_10646846": { "compartment": "compartment_876", "id": "reaction_10646846", "reactome": "R-CEL-5671993", "name": "CIT-3 binds DLG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10646842" ], "products": [ "species_10646844" ], "modifiers": [], "additional_components": [ "WBGene00001006", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "G5ECY0", "WBGene00001006" ] }, "reaction_10663131": { "compartment": "compartment_70101", "id": "reaction_10663131", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663128", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "O01443", "WBGene00015303", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "A0A0K3AW57", "Y75B7AL.4c", "Q23130", "WBGene00012203" ] }, "reaction_10635383": { "compartment": "compartment_70101", "id": "reaction_10635383", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635372" ], "products": [ "species_29370", "species_10635358" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10663692": { "compartment": "compartment_70101", "id": "reaction_10663692", "reactome": "R-CEL-9013109", "name": "RHOC GEFs activate RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10663689", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10636374": { "compartment": "compartment_70101", "id": "reaction_10636374", "reactome": "R-CEL-2197698", "name": "Src phosphorylate WASP,N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636371", "species_113592" ], "products": [ "species_29370", "species_10635306" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "WBGene00002213" ] }, "reaction_10646698": { "compartment": "compartment_876", "id": "reaction_10646698", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10617024" ], "products": [ "species_10646696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00002996", "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "A5PEX5", "WBGene00002996" ] }, "reaction_10645075": { "compartment": "compartment_876", "id": "reaction_10645075", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645069", "species_10604443" ], "products": [ "species_10645073" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663754": { "compartment": "compartment_876", "id": "reaction_10663754", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399", "species_29356" ], "products": [ "species_10635280", "species_29372" ], "modifiers": [ [ "species_10663751", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "species_29420", "Q03206", "ced-10", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q86NH1", "WBGene00006363", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10665856": { "compartment": "compartment_876", "id": "reaction_10665856", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665854" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646651": { "compartment": "compartment_70101", "id": "reaction_10646651", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10646643" ], "products": [ "species_10646645" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10666148": { "compartment": "compartment_876", "id": "reaction_10666148", "reactome": "R-CEL-9714363", "name": "RHOC translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663963": { "compartment": "compartment_876", "id": "reaction_10663963", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10663959" ], "products": [ "species_10663961" ], "modifiers": [], "additional_components": [ "WBGene00004356", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q20496", "WBGene00004356", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10663669": { "compartment": "compartment_70101", "id": "reaction_10663669", "reactome": "R-CEL-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663663", "species_10663661" ], "products": [ "species_10663667" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664047": { "compartment": "compartment_876", "id": "reaction_10664047", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664043", "species_10664034" ], "products": [ "species_10664045" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "Q8I4M6", "WBGene00007840", "O17772", "WBGene00003980", "Q95PX0", "WBGene00006410", "Q21341", "WBGene00002368", "G5EFU0", "WBGene00006443", "Q17850", "WBGene00003911", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "G5EDP9", "WBGene00000001", "Q21408", "WBGene00004951", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "Q9NAN2", "WBGene00003921", "G5EES9", "WBGene00021826", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "G5EES9", "WBGene00021826", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10635380": { "compartment": "compartment_70101", "id": "reaction_10635380", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635376", "species_10620766" ], "products": [ "species_10635378" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "species_113592", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10646757": { "compartment": "compartment_70101", "id": "reaction_10646757", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646734" ], "products": [ "species_29370", "species_10646754" ], "modifiers": [ [ "species_10618307", "catalyst" ] ], "additional_components": [ "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10640501": { "compartment": "compartment_70101", "id": "reaction_10640501", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640497" ], "products": [ "species_10640499" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00018976", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10646808": { "compartment": "compartment_70101", "id": "reaction_10646808", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646802" ], "products": [ "species_29370", "species_10646805" ], "modifiers": [ [ "species_10645086", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10662944": { "compartment": "compartment_70101", "id": "reaction_10662944", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10662941", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "H2L0P5", "WBGene00022391", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476" ] }, "reaction_10635291": { "compartment": "compartment_70101", "id": "reaction_10635291", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10617721" ], "products": [ "species_10635282", "species_10617723" ], "modifiers": [ [ "species_10635289", "inhibitor" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "WBGene00003593" ] }, "reaction_10646561": { "compartment": "compartment_70101", "id": "reaction_10646561", "reactome": "R-CEL-5665761", "name": "FMNL3 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646557", "species_10605408" ], "products": [ "species_10646559" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10665870": { "compartment": "compartment_876", "id": "reaction_10665870", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665868" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663881": { "compartment": "compartment_876", "id": "reaction_10663881", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10663877" ], "products": [ "species_10663879" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "Q22038", "WBGene00004357", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "species_29438" ] }, "reaction_10663710": { "compartment": "compartment_876", "id": "reaction_10663710", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10663707", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "A0A0K3AR51", "F22G12.5c" ] }, "reaction_10646681": { "compartment": "compartment_70101", "id": "reaction_10646681", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10646673" ], "products": [ "species_10646679" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645071": { "compartment": "compartment_876", "id": "reaction_10645071", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645059", "species_10645067" ], "products": [ "species_10645069" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10645765": { "compartment": "compartment_70101", "id": "reaction_10645765", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645762", "species_113592" ], "products": [ "species_29370", "species_10618313", "species_10617721" ], "modifiers": [ [ "species_10645762", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10663883": { "compartment": "compartment_876", "id": "reaction_10663883", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10646677" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663698": { "compartment": "compartment_876", "id": "reaction_10663698", "reactome": "R-CEL-9013110", "name": "RHOC binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10663694" ], "products": [ "species_10663696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646549": { "compartment": "compartment_876", "id": "reaction_10646549", "reactome": "R-CEL-5665748", "name": "FMNL2 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10605408" ], "products": [ "species_10646547" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10646669": { "compartment": "compartment_70101", "id": "reaction_10646669", "reactome": "R-CEL-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10646665" ], "products": [ "species_10646667" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645646": { "compartment": "compartment_70101", "id": "reaction_10645646", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10620766" ], "products": [ "species_10645642" ], "modifiers": [ [ "species_10645644", "inhibitor" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "species_113592", "P10984", "WBGene00000064", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_113592", "species_29438", "P10984", "WBGene00000064", "O62422", "WBGene00012532", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10665850": { "compartment": "compartment_70101", "id": "reaction_10665850", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665846", "species_10663860" ], "products": [ "species_10665848" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "B3WFV9", "WBGene00009920", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203" ] }, "reaction_10645755": { "compartment": "compartment_13949", "id": "reaction_10645755", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645739" ], "products": [ "species_10645753" ], "modifiers": [ [ "species_10645739", "catalyst" ] ], "additional_components": [ "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10663674": { "compartment": "compartment_70101", "id": "reaction_10663674", "reactome": "R-CEL-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828", "species_29356" ], "products": [ "species_10663661", "species_29372" ], "modifiers": [ [ "species_10663671", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10663133": { "compartment": "compartment_70101", "id": "reaction_10663133", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617740", "species_10617721" ], "products": [ "species_10645760", "species_10617738" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10665919": { "compartment": "compartment_20699", "id": "reaction_10665919", "reactome": "R-CEL-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665915", "species_10665868" ], "products": [ "species_10665917" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017" ] }, "reaction_10645095": { "compartment": "compartment_70101", "id": "reaction_10645095", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645073" ], "products": [ "species_29370", "species_10645067", "species_10604443", "species_10645086" ], "modifiers": [ [ "species_10645073", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663842": { "compartment": "compartment_876", "id": "reaction_10663842", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663829" ], "products": [ "species_10608724", "species_29420" ], "modifiers": [ [ "species_10663839", "catalyst" ] ], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "G5ECK4", "WBGene00044989", "Q19572", "WBGene00001674", "O17905", "WBGene00001490", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "A0A0K3AR51", "F22G12.5c", "X5LV34", "WBGene00001366", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10663679": { "compartment": "compartment_876", "id": "reaction_10663679", "reactome": "R-CEL-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663661" ], "products": [ "species_10646828", "species_29420" ], "modifiers": [ [ "species_10663676", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10663618": { "compartment": "compartment_70101", "id": "reaction_10663618", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664000": { "compartment": "compartment_876", "id": "reaction_10664000", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663996", "species_10663959" ], "products": [ "species_10663998" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q94124", "WBGene00004287", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "Q03206", "ced-10", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "species_29438", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q9BL44", "WBGene00022177", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064" ] }, "reaction_10666146": { "compartment": "compartment_12045", "id": "reaction_10666146", "reactome": "R-CEL-9714361", "name": "RHOC activates endoplasmic reticulum effectors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666142", "species_10663620" ], "products": [ "species_10666144" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066" ] }, "reaction_10645593": { "compartment": "compartment_7660", "id": "reaction_10645593", "reactome": "R-CEL-5625849", "name": "Demethylase KDM1A binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645572", "species_10628328" ], "products": [ "species_10645574" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10646582": { "compartment": "compartment_876", "id": "reaction_10646582", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646573", "species_10646578" ], "products": [ "species_10646580" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698", "WBGene00006406", "Q03206", "ced-10", "Q19370", "WBGene00006406", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698" ] }, "reaction_10650007": { "compartment": "compartment_70101", "id": "reaction_10650007", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628563" ], "products": [ "species_10628579" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663391": { "compartment": "compartment_70101", "id": "reaction_10663391", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663357" ], "products": [ "species_10663389" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663332": { "compartment": "compartment_70101", "id": "reaction_10663332", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663320" ], "products": [ "species_10663330" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625371": { "compartment": "compartment_70101", "id": "reaction_10625371", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613343", "species_10625343" ], "products": [ "species_10625369" ], "modifiers": [], "additional_components": [ "WBGene00006887", "WBGene00004829", "Q19019", "WBGene00004829", "Q45FX5", "WBGene00006887" ] }, "reaction_10663909": { "compartment": "compartment_984", "id": "reaction_10663909", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622329", "species_10663905" ], "products": [ "species_10663907" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q22666", "WBGene00011917" ] }, "reaction_10625148": { "compartment": "compartment_70101", "id": "reaction_10625148", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623793", "species_10625144", "species_10608624", "species_10602400" ], "products": [ "species_10625146" ], "modifiers": [], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q18462", "WBGene00016416", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10650185": { "compartment": "compartment_70101", "id": "reaction_10650185", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650179" ], "products": [ "species_10650183" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625379": { "compartment": "compartment_70101", "id": "reaction_10625379", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617312", "species_10625343" ], "products": [ "species_10625373" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10625367": { "compartment": "compartment_70101", "id": "reaction_10625367", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625350", "species_10625345" ], "products": [ "species_10625365" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10622343": { "compartment": "compartment_984", "id": "reaction_10622343", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10622329" ], "products": [ "species_10622331" ], "modifiers": [ [ "species_10622341", "inhibitor" ] ], "additional_components": [ "WBGene00006798", "WBGene00011917", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O44412", "WBGene00020298", "A5PEW5", "WBGene00004364", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10663421": { "compartment": "compartment_984", "id": "reaction_10663421", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10663322": { "compartment": "compartment_70101", "id": "reaction_10663322", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310", "species_10663269" ], "products": [ "species_10663320" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650009": { "compartment": "compartment_70101", "id": "reaction_10650009", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559" ], "products": [ "species_10628563" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650236": { "compartment": "compartment_70101", "id": "reaction_10650236", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650183" ], "products": [ "species_10650234" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663381": { "compartment": "compartment_70101", "id": "reaction_10663381", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663365" ], "products": [ "species_10663367" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663314": { "compartment": "compartment_70101", "id": "reaction_10663314", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310" ], "products": [ "species_10663312" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663482": { "compartment": "compartment_70101", "id": "reaction_10663482", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617052" ], "products": [ "species_29370", "species_10663269" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650353": { "compartment": "compartment_70101", "id": "reaction_10650353", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650347" ], "products": [ "species_10650351" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663318": { "compartment": "compartment_70101", "id": "reaction_10663318", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263" ], "products": [ "species_10663316" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663377": { "compartment": "compartment_70101", "id": "reaction_10663377", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663367" ], "products": [ "species_10663375" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663359": { "compartment": "compartment_70101", "id": "reaction_10663359", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661639" ], "products": [ "species_10663357" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650349": { "compartment": "compartment_70101", "id": "reaction_10650349", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650345" ], "products": [ "species_10650347" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628569": { "compartment": "compartment_70101", "id": "reaction_10628569", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628561" ], "products": [ "species_10628567" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628583": { "compartment": "compartment_70101", "id": "reaction_10628583", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628567" ], "products": [ "species_10628581" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10622841": { "compartment": "compartment_70101", "id": "reaction_10622841", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622832" ], "products": [ "species_10622838" ], "modifiers": [ [ "species_10622832", "catalyst" ] ], "additional_components": [ "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727" ] }, "reaction_10625377": { "compartment": "compartment_70101", "id": "reaction_10625377", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625373", "species_10607816" ], "products": [ "species_10625375" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238", "WBGene00021320", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10650548": { "compartment": "compartment_17957", "id": "reaction_10650548", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10650546" ], "modifiers": [ [ "species_10628579", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10636285": { "compartment": "compartment_7660", "id": "reaction_10636285", "reactome": "R-CEL-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636283" ], "products": [], "modifiers": [], "additional_components": [ "G5EDM7", "WBGene00000901", "P0CG71", "WBGene00006727" ] }, "reaction_10607909": { "compartment": "compartment_7660", "id": "reaction_10607909", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10636243": { "compartment": "compartment_7660", "id": "reaction_10636243", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636237", "species_10597874" ], "products": [ "species_10636235", "species_10636241" ], "modifiers": [], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00006727", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636145": { "compartment": "compartment_876", "id": "reaction_10636145", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636143" ], "products": [], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "G5EDS9", "WBGene00006445", "P20792", "WBGene00000897", "P0CG71", "WBGene00006727" ] }, "reaction_10636343": { "compartment": "compartment_70101", "id": "reaction_10636343", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636336" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727" ] }, "reaction_10635812": { "compartment": "compartment_7660", "id": "reaction_10635812", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873", "species_10635808" ], "products": [ "species_10635810" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "Q21733", "WBGene00000904", "G5EDT1", "WBGene00003020", "F5GUE5", "WBGene00000910", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "P45897", "WBGene00004858", "G5EF11", "WBGene00001161" ] }, "reaction_10635466": { "compartment": "compartment_70101", "id": "reaction_10635466", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10607745" ], "products": [ "species_10635464" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10607715" ], "products": [ "species_10607745" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10642987": { "compartment": "compartment_13231", "id": "reaction_10642987", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642983", "species_10600633" ], "products": [ "species_10642985" ], "modifiers": [], "additional_components": [ "WBGene00010117", "WBGene00004806", "Q9XUY5", "WBGene00010117", "Q22836", "WBGene00004806" ] }, "reaction_10641008": { "compartment": "compartment_876", "id": "reaction_10641008", "reactome": "R-CEL-4332235", "name": "CBL binds TGFBR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607752", "species_10608624" ], "products": [ "species_10641006" ], "modifiers": [], "additional_components": [ "WBGene00000900", "WBGene00004829", "P50488", "WBGene00000900", "Q19019", "WBGene00004829" ] }, "reaction_10636347": { "compartment": "compartment_70101", "id": "reaction_10636347", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613620" ], "products": [ "species_10607792" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636330": { "compartment": "compartment_7660", "id": "reaction_10636330", "reactome": "R-CEL-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10636312" ], "products": [ "species_10636327", "species_427497", "species_10636310" ], "modifiers": [ [ "species_10636312", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10625009": { "compartment": "compartment_7660", "id": "reaction_10625009", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625005" ], "products": [ "species_10625007" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636339": { "compartment": "compartment_70101", "id": "reaction_10636339", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636334", "species_10597908" ], "products": [ "species_10627446", "species_10636336" ], "modifiers": [ [ "species_10636334", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500", "WBGene00006727", "WBGene00000500", "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10607797": { "compartment": "compartment_171062", "id": "reaction_10607797", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607794", "species_113592" ], "products": [ "species_29370", "species_10607778" ], "modifiers": [ [ "species_10607794", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636345": { "compartment": "compartment_7660", "id": "reaction_10636345", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613608", "species_10607873" ], "products": [ "species_10613610" ], "modifiers": [], "additional_components": [ "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636356": { "compartment": "compartment_70101", "id": "reaction_10636356", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10636349" ], "products": [ "species_10636351" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636305": { "compartment": "compartment_7660", "id": "reaction_10636305", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636301", "species_10607873" ], "products": [ "species_10636303" ], "modifiers": [], "additional_components": [ "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636332": { "compartment": "compartment_7660", "id": "reaction_10636332", "reactome": "R-CEL-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636310", "species_10607873" ], "products": [ "species_10636312" ], "modifiers": [], "additional_components": [ "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10607782": { "compartment": "compartment_17941", "id": "reaction_10607782", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607778" ], "products": [ "species_10607737", "species_10607780" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636289": { "compartment": "compartment_7660", "id": "reaction_10636289", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636287" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P0CG71", "WBGene00006727" ] }, "reaction_10607888": { "compartment": "compartment_70101", "id": "reaction_10607888", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607873" ], "modifiers": [ [ "species_10607886", "inhibitor" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10635770": { "compartment": "compartment_70101", "id": "reaction_10635770", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635464" ], "products": [ "species_10635768" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10636354": { "compartment": "compartment_70101", "id": "reaction_10636354", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636351", "species_29356" ], "products": [ "species_10636349", "species_10607792", "species_29372" ], "modifiers": [ [ "species_10636351", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636207": { "compartment": "compartment_70101", "id": "reaction_10636207", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636205" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P0CG71", "WBGene00006727" ] }, "reaction_10636239": { "compartment": "compartment_7660", "id": "reaction_10636239", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636226", "species_10636235" ], "products": [ "species_10636237" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636341": { "compartment": "compartment_70101", "id": "reaction_10636341", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627446", "species_10607790" ], "products": [ "species_10636334" ], "modifiers": [], "additional_components": [ "WBGene00000500", "WBGene00000904", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10636233": { "compartment": "compartment_7660", "id": "reaction_10636233", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607873" ], "products": [ "species_113582", "species_10636226" ], "modifiers": [ [ "species_10636230", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "O17869", "WBGene00009650", "Q9TYP2", "WBGene00000506", "P34425", "WBGene00000507", "P90866", "WBGene00000409", "Q9TVL3", "WBGene00000410" ] }, "reaction_10613623": { "compartment": "compartment_7660", "id": "reaction_10613623", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10613610" ], "products": [ "species_10613620", "species_113550", "species_10607859", "species_10613608" ], "modifiers": [ [ "species_10613610", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636245": { "compartment": "compartment_7660", "id": "reaction_10636245", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636241" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10640756": { "compartment": "compartment_876", "id": "reaction_10640756", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640622", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640625": { "compartment": "compartment_876", "id": "reaction_10640625", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640620" ], "products": [ "species_29370", "species_10640622" ], "modifiers": [ [ "species_10640620", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640831": { "compartment": "compartment_876", "id": "reaction_10640831", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640828", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "O01847", "WBGene00015704", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q19475", "WBGene00001164" ] }, "reaction_10633379": { "compartment": "compartment_161320", "id": "reaction_10633379", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10635744": { "compartment": "compartment_20699", "id": "reaction_10635744", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635741", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q9TZK5", "WBGene00002030", "Q4TTA0", "WBGene00044303" ] }, "reaction_10634068": { "compartment": "compartment_20699", "id": "reaction_10634068", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10633892" ], "products": [ "species_205687", "species_10634052" ], "modifiers": [ [ "species_10634065", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005021" ] }, "reaction_10634930": { "compartment": "compartment_876", "id": "reaction_10634930", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633349" ], "products": [ "species_10633006" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10635710": { "compartment": "compartment_17963", "id": "reaction_10635710", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635705", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10632896": { "compartment": "compartment_161320", "id": "reaction_10632896", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10634893": { "compartment": "compartment_20699", "id": "reaction_10634893", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634851", "species_741440" ], "products": [ "species_10634879", "species_742343" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10635730": { "compartment": "compartment_20699", "id": "reaction_10635730", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10634958" ], "products": [ "species_10634986", "species_742343" ], "modifiers": [ [ "species_10635727", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002029" ] }, "reaction_10635764": { "compartment": "compartment_161320", "id": "reaction_10635764", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10632794": { "compartment": "compartment_161320", "id": "reaction_10632794", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10634060": { "compartment": "compartment_20699", "id": "reaction_10634060", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10634052" ], "products": [ "species_10633930", "species_205687" ], "modifiers": [ [ "species_10634057", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005020" ] }, "reaction_10633424": { "compartment": "compartment_161320", "id": "reaction_10633424", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065212", "species_1605715" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10633421", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10665103": { "compartment": "compartment_20699", "id": "reaction_10665103", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634019", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q09363", "WBGene00005026", "species_266099" ] }, "reaction_10634024": { "compartment": "compartment_20699", "id": "reaction_10634024", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634021", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "O62113", "WBGene00008160", "Q9XU73", "WBGene00011781", "O02304", "WBGene00011650", "O17708", "WBGene00008293", "Q09363", "WBGene00005026", "A0A0K3AUF6", "W07G9.2b", "species_266099", "O17751", "WBGene00008479" ] }, "reaction_10633902": { "compartment": "compartment_20699", "id": "reaction_10633902", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10633864" ], "products": [ "species_10633892", "species_205687" ], "modifiers": [ [ "species_10633897", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005024" ] }, "reaction_10665106": { "compartment": "compartment_161320", "id": "reaction_10665106", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10635766": { "compartment": "compartment_161320", "id": "reaction_10635766", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636009": { "compartment": "compartment_876", "id": "reaction_10636009", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10635722": { "compartment": "compartment_20699", "id": "reaction_10635722", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635042", "species_741440" ], "products": [ "species_742343", "species_10635064" ], "modifiers": [ [ "species_10635715", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002031" ] }, "reaction_10635180": { "compartment": "compartment_17963", "id": "reaction_10635180", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635066" ], "products": [ "species_10635178" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10665110": { "compartment": "compartment_161320", "id": "reaction_10665110", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10633440": { "compartment": "compartment_161320", "id": "reaction_10633440", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "CHEBI:63513", "CHEBI:63511", "CHEBI:63512", "CHEBI:63515", "WBGene00011923" ] }, "reaction_10635762": { "compartment": "compartment_161320", "id": "reaction_10635762", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10634924": { "compartment": "compartment_20699", "id": "reaction_10634924", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634921", "species_2022884" ], "products": [ "species_10634851", "species_2022890" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10646062": { "compartment": "compartment_7660", "id": "reaction_10646062", "reactome": "R-CEL-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10646052" ], "products": [ "species_10646054", "species_5651834" ], "modifiers": [ [ "species_10646059", "catalyst" ] ], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "WBGene00004051" ] }, "reaction_10606556": { "compartment": "compartment_5460", "id": "reaction_10606556", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10606552" ], "products": [ "species_10606554" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10606439": { "compartment": "compartment_70101", "id": "reaction_10606439", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10606436", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10604420": { "compartment": "compartment_70101", "id": "reaction_10604420", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10604417", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "E6N0V1", "WBGene00018819", "Q10656", "WBGene00001184", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10604454": { "compartment": "compartment_70101", "id": "reaction_10604454", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604434" ], "products": [ "species_29370", "species_10604451" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "species_179838", "Q17941", "WBGene00000102", "species_179838", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604445": { "compartment": "compartment_876", "id": "reaction_10604445", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604441" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604436": { "compartment": "compartment_876", "id": "reaction_10604436", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604432" ], "products": [ "species_10604434", "species_10604425" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "G5EED4", "WBGene00010700", "species_179838", "Q17941", "WBGene00000102", "WBGene00010700" ] }, "reaction_10610560": { "compartment": "compartment_876", "id": "reaction_10610560", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605406" ], "products": [ "species_10605408" ], "modifiers": [ [ "species_10610557", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10619825": { "compartment": "compartment_7660", "id": "reaction_10619825", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619821", "species_10619819" ], "products": [ "species_10619823" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00023409", "Q27894", "WBGene00001878", "G5ECR1", "WBGene00023409", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619863": { "compartment": "compartment_7660", "id": "reaction_10619863", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_77087" ], "products": [ "species_10602565", "species_77502" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619860": { "compartment": "compartment_7660", "id": "reaction_10619860", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10619843" ], "products": [ "species_10614288", "species_427498", "species_427497" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10641870": { "compartment": "compartment_7660", "id": "reaction_10641870", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641868" ], "products": [ "species_10641841", "species_10641860", "species_10641866" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642922": { "compartment": "compartment_7660", "id": "reaction_10642922", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10642887" ], "products": [ "species_113550", "species_10642907", "species_10642885" ], "modifiers": [ [ "species_10642919", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "WBGene00018328", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641839": { "compartment": "compartment_7660", "id": "reaction_10641839", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641817" ], "modifiers": [ [ "species_10641836", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10641843": { "compartment": "compartment_7660", "id": "reaction_10641843", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641841" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639827": { "compartment": "compartment_70101", "id": "reaction_10639827", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639821" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10642845": { "compartment": "compartment_70101", "id": "reaction_10642845", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642788", "species_10642841" ], "products": [ "species_10642843" ], "modifiers": [], "additional_components": [ "WBGene00018328", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250" ] }, "reaction_10641858": { "compartment": "compartment_7660", "id": "reaction_10641858", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641822" ], "modifiers": [ [ "species_10641855", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583" ] }, "reaction_10639846": { "compartment": "compartment_7660", "id": "reaction_10639846", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10639841" ], "products": [ "species_113582", "species_10639835" ], "modifiers": [ [ "species_10639843", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000227" ] }, "reaction_10643043": { "compartment": "compartment_70101", "id": "reaction_10643043", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10643038" ], "products": [ "species_10639783", "species_10614711", "species_10643040", "species_10639865" ], "modifiers": [ [ "species_10643038", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q9U266", "WBGene00001838", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838" ] }, "reaction_10639788": { "compartment": "compartment_70101", "id": "reaction_10639788", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639786" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10639869": { "compartment": "compartment_70101", "id": "reaction_10639869", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639867" ], "products": [ "species_10639783", "species_10614711", "species_10639865" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642951": { "compartment": "compartment_70101", "id": "reaction_10642951", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642841", "species_29356" ], "products": [ "species_10642942", "species_29372" ], "modifiers": [ [ "species_10642948", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641824": { "compartment": "compartment_7660", "id": "reaction_10641824", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641729" ], "products": [ "species_10641812" ], "modifiers": [ [ "species_10641822", "catalyst" ], [ "species_10641817", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EC99", "WBGene00008714", "G5EE36", "WBGene00002013", "Q9U3B7", "WBGene00002002", "Q20363", "WBGene00004798", "G5EE65", "WBGene00011906", "P34696", "WBGene00002015", "Q17849", "WBGene00002023", "G5EF99", "WBGene00014233", "B0M0L8", "WBGene00002024", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "Q19227", "WBGene00014233", "P02513", "WBGene00002019", "P06581", "WBGene00002018", "P06582", "WBGene00002016", "Q20660", "WBGene00002021", "Q20164", "WBGene00002012", "P34328", "WBGene00002011", "Q19228", "WBGene00014233", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639832": { "compartment": "compartment_70101", "id": "reaction_10639832", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639830" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10641668": { "compartment": "compartment_70101", "id": "reaction_10641668", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10641665" ], "modifiers": [ [ "species_10609552", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10639859": { "compartment": "compartment_7660", "id": "reaction_10639859", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_10639855" ], "products": [ "species_10639857" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10639877": { "compartment": "compartment_70101", "id": "reaction_10639877", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783" ], "products": [ "species_10639821" ], "modifiers": [ [ "species_10605919", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10642990": { "compartment": "compartment_70101", "id": "reaction_10642990", "reactome": "R-CEL-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642843" ], "products": [ "species_10642887" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10643016": { "compartment": "compartment_70101", "id": "reaction_10643016", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642942", "species_113592" ], "products": [ "species_29370", "species_10642841" ], "modifiers": [ [ "species_10643006", "catalyst" ], [ "species_10643014", "inhibitor" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "O61980", "WBGene00006760", "O44739", "WBGene00000236", "Q05036", "WBGene00016250", "G5EE04", "WBGene00011735" ] }, "reaction_10639839": { "compartment": "compartment_7660", "id": "reaction_10639839", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639835", "species_10619855" ], "products": [ "species_10639837" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10631172": { "compartment": "compartment_70616", "id": "reaction_10631172", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10631169", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10640468": { "compartment": "compartment_984", "id": "reaction_10640468", "reactome": "R-CEL-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10640457", "species_10640455" ], "modifiers": [ [ "species_10640465", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q9BL26", "WBGene00044760", "Q20176", "WBGene00003555" ] }, "reaction_10632241": { "compartment": "compartment_876", "id": "reaction_10632241", "reactome": "R-CEL-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237", "species_10631688" ], "products": [ "species_10632239" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631553": { "compartment": "compartment_984", "id": "reaction_10631553", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631532" ], "products": [ "species_10630560", "species_10631550" ], "modifiers": [ [ "species_10631532", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632145": { "compartment": "compartment_984", "id": "reaction_10632145", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631644" ], "products": [ "species_10631571", "species_10632142" ], "modifiers": [ [ "species_10631644", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632289": { "compartment": "compartment_876", "id": "reaction_10632289", "reactome": "R-CEL-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632239" ], "products": [ "species_10632266", "species_10632259" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637134": { "compartment": "compartment_876", "id": "reaction_10637134", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10615940": { "compartment": "compartment_984", "id": "reaction_10615940", "reactome": "R-CEL-375135", "name": "Basigin binds Matrix metalloproteinase-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615936" ], "products": [ "species_10615938" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "Q8MQ86", "WBGene00017184", "G5ECC4", "WBGene00020646", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10661241": { "compartment": "compartment_984", "id": "reaction_10661241", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661234", "species_10661236" ], "modifiers": [ [ "species_10630560", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10661248": { "compartment": "compartment_984", "id": "reaction_10661248", "reactome": "R-CEL-8940561", "name": "MMP7 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661243", "species_10661238", "species_10661245", "species_10661236" ], "modifiers": [ [ "species_10630596", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632526": { "compartment": "compartment_984", "id": "reaction_10632526", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632524", "species_10632425" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632314": { "compartment": "compartment_984", "id": "reaction_10632314", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631880" ], "products": [ "species_10632312", "species_10630632" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632506": { "compartment": "compartment_984", "id": "reaction_10632506", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632407", "species_10632504" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632165": { "compartment": "compartment_17963", "id": "reaction_10632165", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632163" ], "products": [ "species_10631589" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10632547": { "compartment": "compartment_984", "id": "reaction_10632547", "reactome": "R-CEL-1604763", "name": "Autocatalytic activation of MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632332" ], "products": [ "species_10632544", "species_10630596" ], "modifiers": [ [ "species_10632332", "catalyst" ], [ "species_1604783", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "CHEBI:24505", "species_444761" ] }, "reaction_10661268": { "compartment": "compartment_984", "id": "reaction_10661268", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661265" ], "modifiers": [ [ "species_10630542", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640453": { "compartment": "compartment_984", "id": "reaction_10640453", "reactome": "R-CEL-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636728" ], "products": [ "species_10640444", "species_10640450" ], "modifiers": [ [ "species_10631487", "catalyst" ] ], "additional_components": [ "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632486": { "compartment": "compartment_984", "id": "reaction_10632486", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632427" ], "products": [ "species_10632483", "species_10630542" ], "modifiers": [ [ "species_10632427", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640402": { "compartment": "compartment_876", "id": "reaction_10640402", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10640377" ], "modifiers": [ [ "species_10640399", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDW5", "WBGene00000074", "Q19844", "WBGene00017865", "G5EFD5", "WBGene00006804", "Q9N5X7", "WBGene00016423" ] }, "reaction_10649493": { "compartment": "compartment_5460", "id": "reaction_10649493", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696409" ], "products": [ "species_113556", "species_113548", "species_5693978" ], "modifiers": [ [ "species_10649490", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10632389": { "compartment": "compartment_984", "id": "reaction_10632389", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631787" ], "products": [ "species_10632386", "species_10630578" ], "modifiers": [ [ "species_10631787", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631453": { "compartment": "compartment_984", "id": "reaction_10631453", "reactome": "R-CEL-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430" ], "products": [ "species_10630506" ], "modifiers": [ [ "species_10631450", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632264": { "compartment": "compartment_984", "id": "reaction_10632264", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237" ], "products": [ "species_10632259", "species_10631532" ], "modifiers": [ [ "species_10632261", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631751": { "compartment": "compartment_984", "id": "reaction_10631751", "reactome": "R-CEL-1592362", "name": "Activation of proMMP7 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631708" ], "products": [ "species_10630596", "species_10631726" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632124": { "compartment": "compartment_17963", "id": "reaction_10632124", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632044" ], "products": [ "species_10632122" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10631903": { "compartment": "compartment_984", "id": "reaction_10631903", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631862" ], "products": [ "species_10631898", "species_10631880" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631945": { "compartment": "compartment_984", "id": "reaction_10631945", "reactome": "R-CEL-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623212", "species_10631862" ], "products": [ "species_10631943" ], "modifiers": [], "additional_components": [ "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631594": { "compartment": "compartment_984", "id": "reaction_10631594", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631571" ], "products": [ "species_10615936" ], "modifiers": [ [ "species_10631591", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10630637": { "compartment": "compartment_984", "id": "reaction_10630637", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630506" ], "products": [], "modifiers": [ [ "species_10630634", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640438": { "compartment": "compartment_876", "id": "reaction_10640438", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445" ], "products": [ "species_10640436" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632671": { "compartment": "compartment_17963", "id": "reaction_10632671", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632122" ], "products": [ "species_10632669" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637180": { "compartment": "compartment_876", "id": "reaction_10637180", "reactome": "R-CEL-2534240", "name": "HSPG2 (perlecan) degradation by MMP14, MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10637177", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631608": { "compartment": "compartment_984", "id": "reaction_10631608", "reactome": "R-CEL-1592314", "name": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10631605", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631690": { "compartment": "compartment_876", "id": "reaction_10631690", "reactome": "R-CEL-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631680", "species_10631686" ], "products": [ "species_10631688" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631514": { "compartment": "compartment_984", "id": "reaction_10631514", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631511", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632294": { "compartment": "compartment_876", "id": "reaction_10632294", "reactome": "R-CEL-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632266" ], "products": [ "species_10632291", "species_10631550" ], "modifiers": [ [ "species_10632266", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10608300": { "compartment": "compartment_7660", "id": "reaction_10608300", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608291", "species_10608295" ], "products": [ "species_10608297" ], "modifiers": [ [ "species_10608295", "catalyst" ] ], "additional_components": [ "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "G5EC44", "WBGene00003417", "Q95Y97", "WBGene00019767", "Q95Q27", "WBGene00001997", "G5EGG2", "WBGene00001998", "G5EFI9", "WBGene00002042", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10636084": { "compartment": "compartment_12045", "id": "reaction_10636084", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10603812", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10636089": { "compartment": "compartment_12045", "id": "reaction_10636089", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10636086", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620836": { "compartment": "compartment_876", "id": "reaction_10620836", "reactome": "R-CEL-432110", "name": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605504" ], "products": [ "species_10620831" ], "modifiers": [ [ "species_10620833", "catalyst" ] ], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102" ] }, "reaction_10615241": { "compartment": "compartment_984", "id": "reaction_10615241", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_377604", "species_10615215" ], "products": [ "species_10615239" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "species_74016", "species_109496", "species_266099", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615217": { "compartment": "compartment_876", "id": "reaction_10615217", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615193", "species_10615213" ], "products": [ "species_10615215" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856", "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10616380": { "compartment": "compartment_70101", "id": "reaction_10616380", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616372" ], "products": [ "species_10615209", "species_10616378" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856", "WBGene00000812", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10620443": { "compartment": "compartment_70101", "id": "reaction_10620443", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613787", "species_10615195" ], "products": [ "species_10620441" ], "modifiers": [], "additional_components": [ "WBGene00016416", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615181": { "compartment": "compartment_70101", "id": "reaction_10615181", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615177", "species_179856", "species_10615172" ], "products": [ "species_10615179" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10616374": { "compartment": "compartment_876", "id": "reaction_10616374", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615213", "species_10615239" ], "products": [ "species_10616372" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615259": { "compartment": "compartment_70101", "id": "reaction_10615259", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10615256", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10615232": { "compartment": "compartment_70101", "id": "reaction_10615232", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615179", "species_10615191" ], "products": [ "species_10615193" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856", "WBGene00006771", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10620451": { "compartment": "compartment_70101", "id": "reaction_10620451", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620441" ], "products": [ "species_29370", "species_10620448" ], "modifiers": [ [ "species_10620441", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "Q18462", "WBGene00016416", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10621581": { "compartment": "compartment_876", "id": "reaction_10621581", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621575" ], "products": [ "species_10621579" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615245": { "compartment": "compartment_70101", "id": "reaction_10615245", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10615228" ], "products": [ "species_10615243" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "Q9N5D3", "WBGene00004947", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615237": { "compartment": "compartment_70101", "id": "reaction_10615237", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615204" ], "products": [ "species_29370", "species_10615226" ], "modifiers": [ [ "species_10615204", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615230": { "compartment": "compartment_70101", "id": "reaction_10615230", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615226", "species_10602400" ], "products": [ "species_10615228" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "WBGene00004774", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10626050": { "compartment": "compartment_70101", "id": "reaction_10626050", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617231", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10615207": { "compartment": "compartment_70101", "id": "reaction_10615207", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615197", "species_113592" ], "products": [ "species_29370", "species_10615204" ], "modifiers": [ [ "species_10615197", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10616370": { "compartment": "compartment_70101", "id": "reaction_10616370", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616367" ], "products": [ "species_29370", "species_10615195" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "species_266099", "P34446", "WBGene00003929", "species_179856", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "WBGene00005077" ] }, "reaction_10615199": { "compartment": "compartment_70101", "id": "reaction_10615199", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10615195" ], "products": [ "species_10615197" ], "modifiers": [], "additional_components": [ "WBGene00002213", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10599384", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10659512": { "compartment": "compartment_876", "id": "reaction_10659512", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10599379": { "compartment": "compartment_70101", "id": "reaction_10599379", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10599376", "catalyst" ] ], "additional_components": [ "Q09474", "WBGene00016201", "species_71185" ] }, "reaction_10599408": { "compartment": "compartment_70101", "id": "reaction_10599408", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10599405", "catalyst" ] ], "additional_components": [ "species_113531", "Q19341", "WBGene00010595" ] }, "reaction_10625269": { "compartment": "compartment_70101", "id": "reaction_10625269", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10599398": { "compartment": "compartment_70101", "id": "reaction_10599398", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10599395", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10635687": { "compartment": "compartment_17951", "id": "reaction_10635687", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10635685": { "compartment": "compartment_17951", "id": "reaction_10635685", "reactome": "R-CEL-2066781", "name": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_192314", "species_2066765" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10635683": { "compartment": "compartment_17951", "id": "reaction_10635683", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635681": { "compartment": "compartment_17951", "id": "reaction_10635681", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10635600": { "compartment": "compartment_17957", "id": "reaction_10635600", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10635679": { "compartment": "compartment_17951", "id": "reaction_10635679", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635597": { "compartment": "compartment_12045", "id": "reaction_10635597", "reactome": "R-CEL-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10635602": { "compartment": "compartment_17957", "id": "reaction_10635602", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10660616": { "compartment": "compartment_70101", "id": "reaction_10660616", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660614" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660604": { "compartment": "compartment_70101", "id": "reaction_10660604", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660596" ], "products": [ "species_10660602" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "P34707", "WBGene00004804" ] }, "reaction_10666119": { "compartment": "compartment_70101", "id": "reaction_10666119", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10660612" ], "products": [ "species_10666117" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "P34707", "WBGene00004804", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34707", "WBGene00004804", "LigandDisplayForward?ligandId=7045", "Q17391", "WBGene00000838", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "Q23457", "WBGene00004320" ] }, "reaction_10644873": { "compartment": "compartment_876", "id": "reaction_10644873", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644870" ], "products": [ "species_29370", "species_10644868" ], "modifiers": [ [ "species_10644870", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10626976": { "compartment": "compartment_20699", "id": "reaction_10626976", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_975819", "species_964752" ], "modifiers": [ [ "species_10626973", "catalyst" ] ], "additional_components": [ "species_216667", "Q2PJ74", "WBGene00010284" ] }, "reaction_10649008": { "compartment": "compartment_161320", "id": "reaction_10649008", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10649005", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10626984": { "compartment": "compartment_20699", "id": "reaction_10626984", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975819", "species_914003" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10626981", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10649043": { "compartment": "compartment_17963", "id": "reaction_10649043", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10628551": { "compartment": "compartment_20699", "id": "reaction_10628551", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10628548", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604705", "species_10604589" ], "products": [ "species_10604583", "species_10604707" ], "modifiers": [], "additional_components": [ "WBGene00001372", "Q9U221", "WBGene00013241", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10604711": { "compartment": "compartment_7660", "id": "reaction_10604711", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604605", "species_10604705" ], "products": [ "species_10604707", "species_10604576" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10626216": { "compartment": "compartment_20699", "id": "reaction_10626216", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626190": { "compartment": "compartment_20699", "id": "reaction_10626190", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626214": { "compartment": "compartment_20699", "id": "reaction_10626214", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10661498": { "compartment": "compartment_70101", "id": "reaction_10661498", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627710" ], "products": [ "species_29370", "species_10661496" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10620826": { "compartment": "compartment_876", "id": "reaction_10620826", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10620823", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10620807": { "compartment": "compartment_876", "id": "reaction_10620807", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10620804", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10664833": { "compartment": "compartment_12045", "id": "reaction_10664833", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664831" ], "products": [ "species_10620890" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10626899": { "compartment": "compartment_876", "id": "reaction_10626899", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626896", "catalyst" ] ], "additional_components": [ "G5ECH3", "WBGene00000233", "Q95QT7", "WBGene00001594", "O17274", "WBGene00020836", "Q9N517", "WBGene00021437", "Q17328", "WBGene00001592", "O17402", "WBGene00017314", "A0A1N7SYW0", "WBGene00021146", "Q7YTP9", "WBGene00008076", "Q22741", "WBGene00020767", "Q09453", "WBGene00001586", "G5EBR3", "WBGene00001591", "Q95Q97", "WBGene00000232", "species_159549", "A0A4V0IN81", "WBGene00001587", "G5EEZ3", "WBGene00001593", "A0A4V0IK40", "WBGene00008022", "P90876", "WBGene00009790" ] }, "reaction_10619119": { "compartment": "compartment_876", "id": "reaction_10619119", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618195", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664726": { "compartment": "compartment_12045", "id": "reaction_10664726", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664722", "species_10664720" ], "products": [ "species_10664724" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10628530": { "compartment": "compartment_876", "id": "reaction_10628530", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628525", "species_10628428" ], "products": [ "species_10628527" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10665455": { "compartment": "compartment_876", "id": "reaction_10665455", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10665452", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10665459": { "compartment": "compartment_876", "id": "reaction_10665459", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665457", "species_114523" ], "products": [ "species_10665452" ], "modifiers": [], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10620923": { "compartment": "compartment_984", "id": "reaction_10620923", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10620920", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "species_376186", "O62305", "WBGene00006779", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "G5ECY0", "WBGene00001006" ] }, "reaction_10628532": { "compartment": "compartment_876", "id": "reaction_10628532", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616836", "species_10605064" ], "products": [ "species_10628428" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626927", "catalyst" ] ], "additional_components": [ "Q17511", "WBGene00007191", "species_352003", "O18276", "WBGene00001512" ] }, "reaction_10626740": { "compartment": "compartment_876", "id": "reaction_10626740", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626737", "catalyst" ] ], "additional_components": [ "Q18812", "WBGene00008280", "P41849", "WBGene00020605", "Q9U2E2", "WBGene00012915", "Q9GQ00", "WBGene00003386", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "Q17511", "WBGene00007191", "O18276", "WBGene00001512", "Q6BET0", "WBGene00008551", "G5EEC1", "WBGene00013746", "G5ECN1", "WBGene00013914", "A0A3P6NNS2", "WBGene00017389", "O17041", "WBGene00020528", "Q95Y52", "WBGene00022106", "Q10052", "WBGene00001588", "species_352003", "Q9NA62", "WBGene00013517", "X5LVB0", "WBGene00017399", "Q9U358", "WBGene00012099", "Q21420", "WBGene00010741", "P91985", "WBGene00008223", "G5EEX8", "WBGene00009799", "G5EDN0", "WBGene00018880", "Q21005", "WBGene00010275", "H2KYN9", "WBGene00020657" ] }, "reaction_10628535": { "compartment": "compartment_70101", "id": "reaction_10628535", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10628527", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675" ] }, "reaction_10621327": { "compartment": "compartment_876", "id": "reaction_10621327", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ], [ "species_10621325", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_376186", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "P04630", "WBGene00000285", "G5EGQ9", "WBGene00003774", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_159549", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5ECY0", "WBGene00001006", "G5EDZ8", "WBGene00000288" ] }, "reaction_10624678": { "compartment": "compartment_70101", "id": "reaction_10624678", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624675", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10624481": { "compartment": "compartment_876", "id": "reaction_10624481", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624478", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10624680": { "compartment": "compartment_984", "id": "reaction_10624680", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624673", "species_372533" ], "products": [ "species_10624675" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997", "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10664976": { "compartment": "compartment_70101", "id": "reaction_10664976", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664969", "species_113592" ], "products": [ "species_29370", "species_10664973" ], "modifiers": [ [ "species_10664969", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518" ] }, "reaction_10619115": { "compartment": "compartment_984", "id": "reaction_10619115", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618182" ], "products": [ "species_10618184" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10618187": { "compartment": "compartment_876", "id": "reaction_10618187", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10624682": { "compartment": "compartment_984", "id": "reaction_10624682", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624476", "species_372533" ], "products": [ "species_10624478" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043", "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10619117": { "compartment": "compartment_984", "id": "reaction_10619117", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618193" ], "products": [ "species_10618195" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664985": { "compartment": "compartment_70101", "id": "reaction_10664985", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10664981" ], "products": [ "species_10664983" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00000553", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10626307": { "compartment": "compartment_876", "id": "reaction_10626307", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10626304", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10618079": { "compartment": "compartment_876", "id": "reaction_10618079", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608448", "species_10615689" ], "products": [ "species_10618077" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942" ] }, "reaction_10621804": { "compartment": "compartment_70101", "id": "reaction_10621804", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081", "species_113592", "species_10604515" ], "products": [ "species_29370", "species_10621801" ], "modifiers": [ [ "species_10604515", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401", "Q21465", "WBGene00019727", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P39745", "WBGene00003401", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10624055": { "compartment": "compartment_876", "id": "reaction_10624055", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608453", "species_10618077" ], "products": [ "species_10618081", "species_29372", "species_29420" ], "modifiers": [ [ "species_10609937", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10621565": { "compartment": "compartment_876", "id": "reaction_10621565", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621561", "species_10615689" ], "products": [ "species_10621563" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q5WRR1", "WBGene00006942", "Q18677", "WBGene00000964" ] }, "reaction_10615724": { "compartment": "compartment_876", "id": "reaction_10615724", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615720", "species_10615689" ], "products": [ "species_10615722" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856" ] }, "reaction_10621806": { "compartment": "compartment_70101", "id": "reaction_10621806", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615689" ], "products": [ "species_29370", "species_10615718" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00005077" ] }, "reaction_10621554": { "compartment": "compartment_70101", "id": "reaction_10621554", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10615722" ], "products": [ "species_10621552" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "species_113592", "Q5WRR1", "WBGene00006942", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10618083": { "compartment": "compartment_17940", "id": "reaction_10618083", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081" ], "products": [ "species_10618081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791" ] }, "reaction_10638811": { "compartment": "compartment_7660", "id": "reaction_10638811", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638788", "species_10638181" ], "products": [ "species_10638809", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10658568": { "compartment": "compartment_7660", "id": "reaction_10658568", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658564" ], "products": [ "species_10658566" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658586": { "compartment": "compartment_70101", "id": "reaction_10658586", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10658582" ], "products": [ "species_10658584" ], "modifiers": [], "additional_components": [ "WBGene00017131", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658588": { "compartment": "compartment_70101", "id": "reaction_10658588", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658582" ], "products": [ "species_10638786" ], "modifiers": [ [ "species_10658584", "inhibitor" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658600": { "compartment": "compartment_7660", "id": "reaction_10658600", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658596", "species_10658594" ], "products": [ "species_10658598" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "WBGene00001585", "Q19862", "WBGene00009203", "Q21501", "WBGene00001585", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10622688": { "compartment": "compartment_70101", "id": "reaction_10622688", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_450386" ], "products": [ "species_10622643" ], "modifiers": [], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10622708": { "compartment": "compartment_70101", "id": "reaction_10622708", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622694", "species_10622682" ], "products": [ "species_10622706" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "Q9BLA0", "WBGene00016489", "P41932", "WBGene00003920", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10604062": { "compartment": "compartment_7660", "id": "reaction_10604062", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600734", "species_10600755", "species_10600767", "species_10604056", "species_10600739" ], "products": [ "species_10604060" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10620715": { "compartment": "compartment_70101", "id": "reaction_10620715", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10620712", "catalyst" ] ], "additional_components": [ "A5Z2V7", "WBGene00008533", "G5EG59", "WBGene00000798", "Q9BKR2", "WBGene00021613", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "P90922", "WBGene00010622", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q19103", "WBGene00008502", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10649092": { "compartment": "compartment_70101", "id": "reaction_10649092", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_430042", "species_29356" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10649089", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10622619": { "compartment": "compartment_70101", "id": "reaction_10622619", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622615", "species_10606995" ], "products": [ "species_10622617" ], "modifiers": [], "additional_components": [ "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10620627": { "compartment": "compartment_70101", "id": "reaction_10620627", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620593", "species_29356" ], "products": [ "species_10620595", "species_430004" ], "modifiers": [ [ "species_10620624", "catalyst" ] ], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479", "Q8ITV6", "WBGene00021551", "O62255", "WBGene00003582", "Q21740", "WBGene00011036" ] }, "reaction_10604054": { "compartment": "compartment_7660", "id": "reaction_10604054", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604050", "species_10600698" ], "products": [ "species_10604052" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797" ] }, "reaction_10622686": { "compartment": "compartment_70101", "id": "reaction_10622686", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622645", "species_450523" ], "products": [ "species_10622647" ], "modifiers": [], "additional_components": [ "WBGene00009532", "Q20155", "WBGene00009532" ] }, "reaction_10604044": { "compartment": "compartment_7660", "id": "reaction_10604044", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604038" ], "products": [ "species_10604042", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10622668": { "compartment": "compartment_70101", "id": "reaction_10622668", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622615" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10623677": { "compartment": "compartment_70101", "id": "reaction_10623677", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606995", "species_10622653" ], "products": [ "species_10623675" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10604761": { "compartment": "compartment_7660", "id": "reaction_10604761", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604036", "species_10603997" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10610139": { "compartment": "compartment_70101", "id": "reaction_10610139", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610135", "species_10610130" ], "products": [ "species_10610137" ], "modifiers": [], "additional_components": [ "WBGene00017746", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920" ] }, "reaction_10603876": { "compartment": "compartment_7660", "id": "reaction_10603876", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850", "species_10603872", "species_10603866" ], "products": [ "species_10603874" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00005015", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10604070": { "compartment": "compartment_7660", "id": "reaction_10604070", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10600734", "species_10604068", "species_10600767", "species_10600739" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "WBGene00003904" ] }, "reaction_10622665": { "compartment": "compartment_70101", "id": "reaction_10622665", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620691", "species_10620605", "species_10622647", "species_10620612", "species_10622661" ], "products": [ "species_10622663" ], "modifiers": [], "additional_components": [ "Q93830", "WBGene00010325", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001", "WBGene00021929", "Q20155", "WBGene00009532", "WBGene00003582", "WBGene00012730", "G5EG59", "WBGene00000798", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9BHK7", "WBGene00012730", "O62255", "WBGene00003582", "Q9XXD2", "WBGene00012966", "Q20155", "WBGene00009532", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10622656": { "compartment": "compartment_70101", "id": "reaction_10622656", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622653" ], "modifiers": [ [ "species_10609568", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10604040": { "compartment": "compartment_7660", "id": "reaction_10604040", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604004", "species_10604036" ], "products": [ "species_10604038" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411" ] }, "reaction_10603908": { "compartment": "compartment_7660", "id": "reaction_10603908", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599879", "species_10599884" ], "products": [ "species_10599886" ], "modifiers": [], "additional_components": [ "WBGene00009141", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10604006": { "compartment": "compartment_7660", "id": "reaction_10604006", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604002", "species_10603997" ], "products": [ "species_10604004" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10603901": { "compartment": "compartment_7660", "id": "reaction_10603901", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603894" ], "products": [ "species_10603899" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10620637": { "compartment": "compartment_70101", "id": "reaction_10620637", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620591", "species_429974" ], "products": [ "species_10620593" ], "modifiers": [], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077" ] }, "reaction_10625887": { "compartment": "compartment_70101", "id": "reaction_10625887", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625883", "species_10625863" ], "products": [ "species_10625885" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00004880", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10622684": { "compartment": "compartment_70101", "id": "reaction_10622684", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_113592" ], "products": [ "species_29370", "species_10622682" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10603897": { "compartment": "compartment_7660", "id": "reaction_10603897", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603889" ], "products": [ "species_10603894" ], "modifiers": [ [ "species_10603889", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603892": { "compartment": "compartment_7660", "id": "reaction_10603892", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10603882" ], "products": [ "species_111349", "species_10603889" ], "modifiers": [ [ "species_10603882", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610188": { "compartment": "compartment_13231", "id": "reaction_10610188", "reactome": "R-CEL-191830", "name": "snRNP nuclear import and release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610137" ], "products": [ "species_10610180", "species_10610135", "species_10610186" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "A7LPI7", "WBGene00007702", "WBGene00017746", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "CHEBI:1604", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10603906": { "compartment": "compartment_7660", "id": "reaction_10603906", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603899", "species_77087" ], "products": [ "species_10599965", "species_10601853", "species_10603872", "species_10603903", "species_77502" ], "modifiers": [ [ "species_10603899", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603856": { "compartment": "compartment_7660", "id": "reaction_10603856", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603848", "species_10603854" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604759": { "compartment": "compartment_7660", "id": "reaction_10604759", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604755" ], "products": [ "species_10604757", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10620635": { "compartment": "compartment_70101", "id": "reaction_10620635", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429926", "species_29356" ], "products": [ "species_429925", "species_430042" ], "modifiers": [ [ "species_10620632", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10603852": { "compartment": "compartment_7660", "id": "reaction_10603852", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604066": { "compartment": "compartment_7660", "id": "reaction_10604066", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10604064", "species_112165", "species_10600767" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "Q93233", "WBGene00003904", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304" ] }, "reaction_10603910": { "compartment": "compartment_7660", "id": "reaction_10603910", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599965", "species_10599886" ], "products": [ "species_10599967" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10603885": { "compartment": "compartment_7660", "id": "reaction_10603885", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603878" ], "products": [ "species_113550", "species_10603882" ], "modifiers": [ [ "species_10603878", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603880": { "compartment": "compartment_7660", "id": "reaction_10603880", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10603874" ], "products": [ "species_10603878" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610151": { "compartment": "compartment_70101", "id": "reaction_10610151", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610143" ], "products": [ "species_10610130" ], "modifiers": [ [ "species_10610148", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:2274", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "WBGene00011631" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10604052" ], "products": [ "species_10604056" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10659874": { "compartment": "compartment_70101", "id": "reaction_10659874", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659871", "species_113592" ], "products": [ "species_29370", "species_10659858" ], "modifiers": [ [ "species_10659871", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10659867": { "compartment": "compartment_70101", "id": "reaction_10659867", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659858", "species_113592" ], "products": [ "species_29370", "species_10659864" ], "modifiers": [ [ "species_10659858", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10641084": { "compartment": "compartment_7660", "id": "reaction_10641084", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641071" ], "products": [ "species_113582", "species_10641081" ], "modifiers": [ [ "species_10641067", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10641029": { "compartment": "compartment_70101", "id": "reaction_10641029", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641021" ], "products": [ "species_29370", "species_10641016" ], "modifiers": [ [ "species_10641021", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10637600": { "compartment": "compartment_70101", "id": "reaction_10637600", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635196", "species_74016", "species_10604898" ], "products": [ "species_10637574" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "species_912516", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641019": { "compartment": "compartment_70101", "id": "reaction_10641019", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641016" ], "products": [ "species_29370", "species_10641014", "species_10604898" ], "modifiers": [ [ "species_10641016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641025": { "compartment": "compartment_70101", "id": "reaction_10641025", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620916", "species_10604898" ], "products": [ "species_10641021" ], "modifiers": [ [ "species_10641023", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641069": { "compartment": "compartment_7660", "id": "reaction_10641069", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641063" ], "products": [ "species_10641067" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10640879": { "compartment": "compartment_876", "id": "reaction_10640879", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640874" ], "products": [ "species_10640857", "species_10605064", "species_10640864" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "P51875", "WBGene00001648", "Q9N2V6", "WBGene00001678" ] }, "reaction_10640877": { "compartment": "compartment_876", "id": "reaction_10640877", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640870", "species_29438" ], "products": [ "species_10640874", "species_29420" ], "modifiers": [ [ "species_10640870", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681" ] }, "reaction_10641175": { "compartment": "compartment_70101", "id": "reaction_10641175", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641169" ], "products": [ "species_10641173" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10603920": { "compartment": "compartment_5460", "id": "reaction_10603920", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77252", "species_113526" ], "products": [ "species_77253", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603922": { "compartment": "compartment_5460", "id": "reaction_10603922", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603961": { "compartment": "compartment_5460", "id": "reaction_10603961", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10613700": { "compartment": "compartment_70101", "id": "reaction_10613700", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10613697", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10662871": { "compartment": "compartment_161320", "id": "reaction_10662871", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662869" ], "products": [ "species_10662867", "species_350136" ], "modifiers": [], "additional_components": [ "species_350136", "Q93212", "WBGene00004944", "WBGene00004944" ] }, "reaction_10662875": { "compartment": "compartment_7660", "id": "reaction_10662875", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8963912", "species_10616155" ], "products": [ "species_10662873" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "species_8963912" ] }, "reaction_10629238": { "compartment": "compartment_876", "id": "reaction_10629238", "reactome": "R-CEL-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629233" ], "products": [ "species_29370", "species_10629235" ], "modifiers": [ [ "species_10629233", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643411": { "compartment": "compartment_7660", "id": "reaction_10643411", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10636603": { "compartment": "compartment_984", "id": "reaction_10636603", "reactome": "R-CEL-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636599", "species_10631599" ], "products": [ "species_10636601" ], "modifiers": [], "additional_components": [ "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881", "WBGene00006787", "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "Q06561", "WBGene00006787", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881" ] }, "reaction_10614244": { "compartment": "compartment_12045", "id": "reaction_10614244", "reactome": "R-CEL-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614257": { "compartment": "compartment_17960", "id": "reaction_10614257", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10614254", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603732": { "compartment": "compartment_12045", "id": "reaction_10603732", "reactome": "R-CEL-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10603729", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614249": { "compartment": "compartment_17960", "id": "reaction_10614249", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10650224": { "compartment": "compartment_12045", "id": "reaction_10650224", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6786220", "species_29368" ], "products": [ "species_29366", "species_29356", "species_6786225" ], "modifiers": [ [ "species_10650221", "catalyst" ] ], "additional_components": [ "WBGene00011830" ] }, "reaction_10614237": { "compartment": "compartment_12045", "id": "reaction_10614237", "reactome": "R-CEL-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10614234", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614264": { "compartment": "compartment_12045", "id": "reaction_10614264", "reactome": "R-CEL-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614262": { "compartment": "compartment_17960", "id": "reaction_10614262", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10614259", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10610411": { "compartment": "compartment_70101", "id": "reaction_10610411", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193079" ], "products": [ "species_29366", "species_29460", "species_193066", "species_29356" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10603727": { "compartment": "compartment_17960", "id": "reaction_10603727", "reactome": "R-CEL-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603819": { "compartment": "compartment_17960", "id": "reaction_10603819", "reactome": "R-CEL-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614232": { "compartment": "compartment_17960", "id": "reaction_10614232", "reactome": "R-CEL-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10603636", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603721": { "compartment": "compartment_17960", "id": "reaction_10603721", "reactome": "R-CEL-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605850": { "compartment": "compartment_17957", "id": "reaction_10605850", "reactome": "R-CEL-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603725": { "compartment": "compartment_17960", "id": "reaction_10603725", "reactome": "R-CEL-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614269": { "compartment": "compartment_12045", "id": "reaction_10614269", "reactome": "R-CEL-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603723": { "compartment": "compartment_17957", "id": "reaction_10603723", "reactome": "R-CEL-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614252": { "compartment": "compartment_12045", "id": "reaction_10614252", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614242": { "compartment": "compartment_12045", "id": "reaction_10614242", "reactome": "R-CEL-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614276": { "compartment": "compartment_12045", "id": "reaction_10614276", "reactome": "R-CEL-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614274": { "compartment": "compartment_12045", "id": "reaction_10614274", "reactome": "R-CEL-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614271", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603817": { "compartment": "compartment_12045", "id": "reaction_10603817", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10637598": { "compartment": "compartment_70101", "id": "reaction_10637598", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637578" ], "products": [ "species_10637596" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10638009": { "compartment": "compartment_70101", "id": "reaction_10638009", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473610" ], "products": [ "species_10636648" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10626966": { "compartment": "compartment_70101", "id": "reaction_10626966", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10626963", "catalyst" ] ], "additional_components": [ "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10602452": { "compartment": "compartment_70101", "id": "reaction_10602452", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473604" ], "products": [ "species_10602450" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637084": { "compartment": "compartment_70101", "id": "reaction_10637084", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_74016", "species_83910" ], "modifiers": [ [ "species_10602105", "catalyst" ] ], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10636806": { "compartment": "compartment_70101", "id": "reaction_10636806", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10636803", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10637063": { "compartment": "compartment_2514888", "id": "reaction_10637063", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637061" ], "products": [ "species_10637052", "species_10637059" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10602107": { "compartment": "compartment_70101", "id": "reaction_10602107", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10602103" ], "products": [ "species_10602105" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10637131": { "compartment": "compartment_2514888", "id": "reaction_10637131", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637121", "species_2530486" ], "products": [ "species_10637057", "species_111294" ], "modifiers": [ [ "species_10637128", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10626938": { "compartment": "compartment_984", "id": "reaction_10626938", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975591", "species_109276" ], "products": [ "species_426576", "species_975590" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10637150": { "compartment": "compartment_70101", "id": "reaction_10637150", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637140", "species_2534019" ], "products": [ "species_10637048", "species_76194" ], "modifiers": [ [ "species_10637145", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "WBGene00020549" ] }, "reaction_10642008": { "compartment": "compartment_5460", "id": "reaction_10642008", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10642005", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10637081": { "compartment": "compartment_70101", "id": "reaction_10637081", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602105" ], "products": [ "species_30991", "species_10602103" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10638007": { "compartment": "compartment_70101", "id": "reaction_10638007", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10626954" ], "products": [ "species_29366", "species_10626952" ], "modifiers": [ [ "species_10638004", "catalyst" ] ], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10637175": { "compartment": "compartment_70101", "id": "reaction_10637175", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637156" ], "products": [ "species_10637140", "species_174390" ], "modifiers": [ [ "species_10637172", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q965Y1", "WBGene00003129", "species_880069", "H1UBK1", "WBGene00003130" ] }, "reaction_10636780": { "compartment": "compartment_70101", "id": "reaction_10636780", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_70106", "species_2864103", "species_30927" ], "modifiers": [ [ "species_10636772", "catalyst" ], [ "species_10636778", "catalyst" ] ], "additional_components": [ "species_2534407", "CHEBI:70761", "CHEBI:70760", "CHEBI:70762", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10636650": { "compartment": "compartment_70101", "id": "reaction_10636650", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636648" ], "products": [ "species_10602448", "species_2473616" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10638750": { "compartment": "compartment_70101", "id": "reaction_10638750", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10602103" ], "products": [ "species_10638748" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q94288", "WBGene00000287", "A8WI01", "WBGene00000562", "Q18136", "WBGene00006861", "species_74016", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q7Z205", "WBGene00000563", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "O02159", "WBGene00020378", "Q9N4C1", "WBGene00022295", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10636642": { "compartment": "compartment_984", "id": "reaction_10636642", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636634", "species_2395761" ], "products": [ "species_10636636" ], "modifiers": [], "additional_components": [ "WBGene00011726", "G5EEB8", "WBGene00011726", "species_5623649" ] }, "reaction_10636646": { "compartment": "compartment_70101", "id": "reaction_10636646", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473616" ], "products": [ "species_10636644" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637319": { "compartment": "compartment_70101", "id": "reaction_10637319", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10637309" ], "products": [ "species_10637317" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "O02217", "WBGene00007710", "P36609", "WBGene00003564", "species_74016", "O02217", "WBGene00007710" ] }, "reaction_10636629": { "compartment": "compartment_70101", "id": "reaction_10636629", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10626950" ], "products": [ "species_10626954" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648" ] }, "reaction_10626956": { "compartment": "compartment_70101", "id": "reaction_10626956", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626950", "species_975590" ], "products": [ "species_10626952" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10636640": { "compartment": "compartment_984", "id": "reaction_10636640", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636636", "species_10636597" ], "products": [ "species_10636638" ], "modifiers": [], "additional_components": [ "G5EEB8", "WBGene00011726", "species_5623649", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "G5EEB8", "WBGene00011726", "species_5623649", "O44578", "WBGene00022808" ] }, "reaction_10636485": { "compartment": "compartment_7660", "id": "reaction_10636485", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636483", "species_10605870" ], "products": [ "species_10636465" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00004043", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636457": { "compartment": "compartment_7660", "id": "reaction_10636457", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10636183" ], "products": [ "species_10636455" ], "modifiers": [ [ "species_10636174", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636453": { "compartment": "compartment_7660", "id": "reaction_10636453", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636196" ], "products": [ "species_113582", "species_10636183", "species_10636451" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "species_113531", "Q9GYI0", "WBGene00017920", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636176": { "compartment": "compartment_7660", "id": "reaction_10636176", "reactome": "R-CEL-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10598308" ], "products": [ "species_10636174" ], "modifiers": [], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "WBGene00003020", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636495": { "compartment": "compartment_7660", "id": "reaction_10636495", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636200", "species_77087" ], "products": [ "species_10636196", "species_77502" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "WBGene00004781" ] }, "reaction_10636435": { "compartment": "compartment_20699", "id": "reaction_10636435", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636427", "species_113592" ], "products": [ "species_29370", "species_10636432" ], "modifiers": [ [ "species_10636427", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017" ] }, "reaction_10636487": { "compartment": "compartment_7660", "id": "reaction_10636487", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636455" ], "products": [ "species_113582", "species_10636483" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636696": { "compartment": "compartment_20699", "id": "reaction_10636696", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636677" ], "products": [ "species_29370", "species_10636683" ], "modifiers": [ [ "species_10636693", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10636481": { "compartment": "compartment_7660", "id": "reaction_10636481", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636465" ], "products": [ "species_113582", "species_10636478" ], "modifiers": [ [ "species_10636465", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636203": { "compartment": "compartment_7660", "id": "reaction_10636203", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10636196", "species_113685" ], "products": [ "species_10636200", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10636196", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920" ] }, "reaction_10611278": { "compartment": "compartment_7660", "id": "reaction_10611278", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611266" ], "products": [ "species_113582", "species_10611276" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611288": { "compartment": "compartment_7660", "id": "reaction_10611288", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611283" ], "products": [ "species_113582", "species_10611286" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611197": { "compartment": "compartment_7660", "id": "reaction_10611197", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611166": { "compartment": "compartment_7660", "id": "reaction_10611166", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10664163": { "compartment": "compartment_70101", "id": "reaction_10664163", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664166": { "compartment": "compartment_70101", "id": "reaction_10664166", "reactome": "R-CEL-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664168": { "compartment": "compartment_70101", "id": "reaction_10664168", "reactome": "R-CEL-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620391": { "compartment": "compartment_70101", "id": "reaction_10620391", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10604843", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618931": { "compartment": "compartment_70101", "id": "reaction_10618931", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070" ], "products": [ "species_10615234" ], "modifiers": [], "additional_components": [ "WBGene00005077", "WBGene00005077" ] }, "reaction_10648796": { "compartment": "compartment_70101", "id": "reaction_10648796", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607380" ], "products": [ "species_10607378" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "WBGene00004467" ] }, "reaction_10648793": { "compartment": "compartment_7660", "id": "reaction_10648793", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648788" ], "products": [ "species_10648790", "species_10597874" ], "modifiers": [ [ "species_10648788", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10607397": { "compartment": "compartment_5460", "id": "reaction_10607397", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607392", "species_31649" ], "products": [ "species_113596", "species_10607394" ], "modifiers": [ [ "species_10607392", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187" ] }, "reaction_10607405": { "compartment": "compartment_5460", "id": "reaction_10607405", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607394", "species_73663" ], "products": [ "species_76633", "species_10607392" ], "modifiers": [ [ "species_10607402", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "WBGene00002855" ] }, "reaction_10654352": { "compartment": "compartment_70616", "id": "reaction_10654352", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654304", "species_10654348" ], "products": [ "species_10654350" ], "modifiers": [], "additional_components": [ "Q9BL33", "WBGene00022169", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "O18236", "WBGene00013308", "Q23098", "WBGene00012166", "species_113596", "P90789", "WBGene00008414", "O02267", "WBGene00009740", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596", "Q9N3H3", "WBGene00021800", "Q93931", "WBGene00011123", "O18236", "WBGene00013308", "P90789", "WBGene00008414", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q22619", "WBGene00020636", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q94360", "WBGene00012376", "Q9BL33", "WBGene00022169", "I2HAE1", "WBGene00021421", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "Q93873", "WBGene00001520", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "Q86NC2", "WBGene00020417", "Q17439", "WBGene00007113", "Q23098", "WBGene00012166", "species_113596", "O02267", "WBGene00009740", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q09644", "WBGene00014227" ] }, "reaction_10654384": { "compartment": "compartment_5460", "id": "reaction_10654384", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654336", "species_10654346", "species_10654331", "species_10654341" ], "products": [ "species_10654348" ], "modifiers": [], "additional_components": [ "WBGene00011123", "WBGene00021421", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596", "WBGene00007113", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10655491": { "compartment": "compartment_5460", "id": "reaction_10655491", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654329", "species_10654320", "species_10654324", "species_10654322", "species_10654313" ], "products": [ "species_10654331" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q9N3H3", "WBGene00021800", "species_113596", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10635778": { "compartment": "compartment_70101", "id": "reaction_10635778", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635776" ], "products": [ "species_10614163" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10614183": { "compartment": "compartment_70101", "id": "reaction_10614183", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614163" ], "products": [ "species_10614181" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10660554": { "compartment": "compartment_5460", "id": "reaction_10660554", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607390", "species_2162265" ], "products": [ "species_2162252", "species_10660546" ], "modifiers": [ [ "species_10660551", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10660627": { "compartment": "compartment_70101", "id": "reaction_10660627", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_71285", "species_10660619" ], "modifiers": [ [ "species_10660624", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10660565": { "compartment": "compartment_70101", "id": "reaction_10660565", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_10660557", "species_71285" ], "modifiers": [ [ "species_10660562", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10660587": { "compartment": "compartment_70101", "id": "reaction_10660587", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10643036" ], "products": [ "species_71285", "species_10660579" ], "modifiers": [ [ "species_10660584", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10620234": { "compartment": "compartment_876", "id": "reaction_10620234", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_10620228" ], "products": [ "species_10620232" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "G5EF96", "unc-40" ] }, "reaction_10661405": { "compartment": "compartment_17957", "id": "reaction_10661405", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634735" ], "products": [ "species_10634737" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10608764": { "compartment": "compartment_70101", "id": "reaction_10608764", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608761" ], "products": [ "species_29370", "species_10608706" ], "modifiers": [ [ "species_10608761", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608753": { "compartment": "compartment_70101", "id": "reaction_10608753", "reactome": "R-CEL-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608746", "species_10597908" ], "products": [ "species_10608750" ], "modifiers": [ [ "species_10608746", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10658941": { "compartment": "compartment_876", "id": "reaction_10658941", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658936", "species_113592" ], "products": [ "species_29370", "species_10658938" ], "modifiers": [ [ "species_10658936", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10658951": { "compartment": "compartment_876", "id": "reaction_10658951", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658938", "species_29356" ], "products": [ "species_10658936", "species_29372" ], "modifiers": [ [ "species_10658948", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "WBGene00004213" ] }, "reaction_10608704": { "compartment": "compartment_70101", "id": "reaction_10608704", "reactome": "R-CEL-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608631", "species_10597908" ], "products": [ "species_10608701" ], "modifiers": [ [ "species_10608631", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608735": { "compartment": "compartment_70101", "id": "reaction_10608735", "reactome": "R-CEL-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608731", "species_10608708" ], "products": [ "species_10608733" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532" ] }, "reaction_10608775": { "compartment": "compartment_70101", "id": "reaction_10608775", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608770", "species_10597908" ], "products": [ "species_10608772", "species_10608761" ], "modifiers": [ [ "species_10608770", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532", "WBGene00006727", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "P0CG71", "WBGene00006727", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10608757": { "compartment": "compartment_70101", "id": "reaction_10608757", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10602400" ], "products": [ "species_10608755" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10608779": { "compartment": "compartment_70101", "id": "reaction_10608779", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10608731" ], "products": [ "species_10608777" ], "modifiers": [], "additional_components": [ "WBGene00004829", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10608742": { "compartment": "compartment_70101", "id": "reaction_10608742", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608706", "species_10597908" ], "products": [ "species_10608739" ], "modifiers": [ [ "species_10608706", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608768": { "compartment": "compartment_70101", "id": "reaction_10608768", "reactome": "R-CEL-183072", "name": "EGFR non-clathrin mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608683", "species_10608631", "species_10608658", "species_10608639" ], "products": [ "species_10608685" ], "modifiers": [], "additional_components": [ "WBGene00001224", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10608710": { "compartment": "compartment_70101", "id": "reaction_10608710", "reactome": "R-CEL-182994", "name": "Assembly of EGFR complex in clathrin-coated vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10608706" ], "products": [ "species_10608708" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791" ] }, "reaction_10608634": { "compartment": "compartment_70101", "id": "reaction_10608634", "reactome": "R-CEL-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608626" ], "products": [ "species_29370", "species_10608631" ], "modifiers": [ [ "species_10608626", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608766": { "compartment": "compartment_70101", "id": "reaction_10608766", "reactome": "R-CEL-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608755", "species_10608528" ], "products": [ "species_10608761" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608759": { "compartment": "compartment_876", "id": "reaction_10608759", "reactome": "R-CEL-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608624" ], "products": [ "species_10608626" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608699": { "compartment": "compartment_70101", "id": "reaction_10608699", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608685", "species_10597908" ], "products": [ "species_10608696" ], "modifiers": [ [ "species_10608685", "catalyst" ] ], "additional_components": [ "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00006727", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10658943": { "compartment": "compartment_876", "id": "reaction_10658943", "reactome": "R-CEL-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608708", "species_10608658", "species_179856", "species_10608639" ], "products": [ "species_10658936" ], "modifiers": [], "additional_components": [ "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10661673": { "compartment": "compartment_70101", "id": "reaction_10661673", "reactome": "R-CEL-8951490", "name": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608733" ], "products": [ "species_10608683", "species_10608770" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10664920": { "compartment": "compartment_984", "id": "reaction_10664920", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10664916" ], "products": [ "species_10664918" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344", "WBGene00000039", "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q18581", "WBGene00000039", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344" ] }, "reaction_10664965": { "compartment": "compartment_984", "id": "reaction_10664965", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10648914", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "A0A1C3NSL8", "WBGene00017478" ] }, "reaction_10641650": { "compartment": "compartment_7660", "id": "reaction_10641650", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641629", "species_10638181" ], "products": [ "species_10641648", "species_10638173" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "P55853", "WBGene00004888", "WBGene00006706" ] }, "reaction_10604599": { "compartment": "compartment_7660", "id": "reaction_10604599", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604596" ], "products": [ "species_10604589", "species_110216" ], "modifiers": [ [ "species_10604596", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604615": { "compartment": "compartment_7660", "id": "reaction_10604615", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604612" ], "products": [ "species_10604605", "species_110225" ], "modifiers": [ [ "species_10604612", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604629": { "compartment": "compartment_7660", "id": "reaction_10604629", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604626" ], "products": [ "species_10604605", "species_5637659" ], "modifiers": [ [ "species_10604626", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604592": { "compartment": "compartment_7660", "id": "reaction_10604592", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604585" ], "products": [ "species_29554", "species_10604589" ], "modifiers": [ [ "species_10604585", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604718": { "compartment": "compartment_7660", "id": "reaction_10604718", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604707" ], "products": [ "species_10604715" ], "modifiers": [ [ "species_10604707", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10646034": { "compartment": "compartment_7660", "id": "reaction_10646034", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715" ], "products": [ "species_10646032" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10604608": { "compartment": "compartment_7660", "id": "reaction_10604608", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604603" ], "products": [ "species_10604605", "species_110223" ], "modifiers": [ [ "species_10604603", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604622": { "compartment": "compartment_7660", "id": "reaction_10604622", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604619" ], "products": [ "species_30140", "species_10604605" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10603043": { "compartment": "compartment_70101", "id": "reaction_10603043", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10649471": { "compartment": "compartment_12045", "id": "reaction_10649471", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10649468", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10623982": { "compartment": "compartment_70101", "id": "reaction_10623982", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10623979", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10654790": { "compartment": "compartment_12045", "id": "reaction_10654790", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10654787", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10603094": { "compartment": "compartment_70101", "id": "reaction_10603094", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10603087", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10603055": { "compartment": "compartment_70101", "id": "reaction_10603055", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10603052", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10603104": { "compartment": "compartment_70101", "id": "reaction_10603104", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10603101", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10620748": { "compartment": "compartment_70101", "id": "reaction_10620748", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620739", "species_10620744" ], "products": [ "species_10620746" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10622178": { "compartment": "compartment_70101", "id": "reaction_10622178", "reactome": "R-CEL-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622174", "species_10608499" ], "products": [ "species_10622176" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00016197", "O16785", "WBGene00003932", "Q09476", "WBGene00016197" ] }, "reaction_10620734": { "compartment": "compartment_70101", "id": "reaction_10620734", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620725", "species_10620730" ], "products": [ "species_10620732" ], "modifiers": [], "additional_components": [ "WBGene00000228", "WBGene00003932", "O16785", "WBGene00003932", "Q23158", "WBGene00000228" ] }, "reaction_10621028": { "compartment": "compartment_70101", "id": "reaction_10621028", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10620730" ], "products": [ "species_10621026" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10608576": { "compartment": "compartment_70101", "id": "reaction_10608576", "reactome": "R-CEL-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_29372", "species_10608574" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608461": { "compartment": "compartment_70101", "id": "reaction_10608461", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604177", "species_10602400" ], "products": [ "species_10608459" ], "modifiers": [], "additional_components": [ "WBGene00004928", "WBGene00004774", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608619": { "compartment": "compartment_70101", "id": "reaction_10608619", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10608459" ], "products": [ "species_10608549" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608535": { "compartment": "compartment_70101", "id": "reaction_10608535", "reactome": "R-CEL-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608497", "species_29356" ], "products": [ "species_10608503", "species_10608482", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "G5ECJ6", "WBGene00000812", "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "WBGene00000812", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608547": { "compartment": "compartment_70101", "id": "reaction_10608547", "reactome": "R-CEL-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_10608545", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608597": { "compartment": "compartment_70101", "id": "reaction_10608597", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10608594", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608599": { "compartment": "compartment_70101", "id": "reaction_10608599", "reactome": "R-CEL-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608551" ], "products": [ "species_10608553" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608559": { "compartment": "compartment_70101", "id": "reaction_10608559", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608553", "species_113592" ], "products": [ "species_29370", "species_10608530" ], "modifiers": [ [ "species_10608553", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10617088": { "compartment": "compartment_984", "id": "reaction_10617088", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617085" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_10615845", "species_114523" ], "modifiers": [ [ "species_10617085", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617033": { "compartment": "compartment_374932", "id": "reaction_10617033", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10617091": { "compartment": "compartment_876", "id": "reaction_10617091", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10617083", "species_10614053", "species_10614048" ], "products": [ "species_10617085" ], "modifiers": [ [ "species_10617083", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10619748": { "compartment": "compartment_876", "id": "reaction_10619748", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10619743", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_109496", "species_74113", "species_74016", "species_109496", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10617308": { "compartment": "compartment_70101", "id": "reaction_10617308", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617306" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617233", "catalyst" ], [ "species_10617202", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_111349", "Q18246", "WBGene00004307", "species_29438", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617235": { "compartment": "compartment_876", "id": "reaction_10617235", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617228": { "compartment": "compartment_12045", "id": "reaction_10617228", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617218" ], "products": [ "species_10617226" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10617204": { "compartment": "compartment_876", "id": "reaction_10617204", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617200", "species_30389" ], "products": [ "species_10617202" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617304": { "compartment": "compartment_876", "id": "reaction_10617304", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617302" ], "products": [ "species_10617302" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "WBGene00002189" ] }, "reaction_10601861": { "compartment": "compartment_7660", "id": "reaction_10601861", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601855" ], "products": [ "species_10601775", "species_10601859" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "P48322", "WBGene00007980", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "WBGene00007980", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749" ] }, "reaction_10601779": { "compartment": "compartment_7660", "id": "reaction_10601779", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601775", "species_10601770" ], "products": [ "species_10601777" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q9U3I0", "WBGene00009078", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q9U3I0", "WBGene00009078", "P48322", "WBGene00007980", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999" ] }, "reaction_10602569": { "compartment": "compartment_350", "id": "reaction_10602569", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10601859", "catalyst" ], [ "species_10602567", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "G5EET5", "WBGene00001995" ] }, "reaction_10637186": { "compartment": "compartment_876", "id": "reaction_10637186", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637182", "species_1297302" ], "products": [ "species_10637184" ], "modifiers": [], "additional_components": [ "WBGene00011923", "G5ECE8", "WBGene00011923", "species_1297302" ] }, "reaction_10637196": { "compartment": "compartment_876", "id": "reaction_10637196", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10637193", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10614415": { "compartment": "compartment_876", "id": "reaction_10614415", "reactome": "R-CEL-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614410" ], "products": [ "species_10608528", "species_10612190" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038" ] }, "reaction_10604456": { "compartment": "compartment_70101", "id": "reaction_10604456", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10602400" ], "products": [ "species_10602407" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10608588": { "compartment": "compartment_70101", "id": "reaction_10608588", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608585", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614408": { "compartment": "compartment_876", "id": "reaction_10614408", "reactome": "R-CEL-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10612156" ], "products": [ "species_10614406" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608477": { "compartment": "compartment_876", "id": "reaction_10608477", "reactome": "R-CEL-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608473" ], "products": [ "species_10608475" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608603": { "compartment": "compartment_70101", "id": "reaction_10608603", "reactome": "R-CEL-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10608528" ], "products": [ "species_10608585" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608581": { "compartment": "compartment_70101", "id": "reaction_10608581", "reactome": "R-CEL-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608578", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10665754": { "compartment": "compartment_459", "id": "reaction_10665754", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10665750" ], "products": [ "species_10665752" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10608566": { "compartment": "compartment_70101", "id": "reaction_10608566", "reactome": "R-CEL-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608475", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608612": { "compartment": "compartment_70101", "id": "reaction_10608612", "reactome": "R-CEL-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608609", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608601": { "compartment": "compartment_984", "id": "reaction_10608601", "reactome": "R-CEL-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10608471" ], "products": [ "species_10608473" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614413": { "compartment": "compartment_70101", "id": "reaction_10614413", "reactome": "R-CEL-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614406", "species_113592" ], "products": [ "species_29370", "species_10614410" ], "modifiers": [ [ "species_10614406", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10598294": { "compartment": "compartment_70101", "id": "reaction_10598294", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10598290" ], "products": [ "species_10598292" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10609629": { "compartment": "compartment_7660", "id": "reaction_10609629", "reactome": "R-CEL-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609624" ], "products": [ "species_113582", "species_10605292", "species_10598141" ], "modifiers": [ [ "species_10609624", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10609622": { "compartment": "compartment_7660", "id": "reaction_10609622", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598298" ], "products": [ "species_113582", "species_10598141" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10609626": { "compartment": "compartment_7660", "id": "reaction_10609626", "reactome": "R-CEL-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598311", "species_10598141" ], "products": [ "species_10609624" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10605940": { "compartment": "compartment_13231", "id": "reaction_10605940", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598292" ], "products": [ "species_10598298" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10638555": { "compartment": "compartment_70101", "id": "reaction_10638555", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10638551" ], "products": [ "species_10638553" ], "modifiers": [], "additional_components": [ "WBGene00003405", "Q23255", "WBGene00003405", "species_874088" ] }, "reaction_10645205": { "compartment": "compartment_876", "id": "reaction_10645205", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645197" ], "products": [ "species_29370", "species_10645203" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "WBGene00005077" ] }, "reaction_10644469": { "compartment": "compartment_876", "id": "reaction_10644469", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642488", "species_112275" ], "products": [ "species_10644467" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10653154": { "compartment": "compartment_6799713", "id": "reaction_10653154", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653046" ], "products": [ "species_10653152" ], "modifiers": [], "additional_components": [ "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064", "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064" ] }, "reaction_10644482": { "compartment": "compartment_876", "id": "reaction_10644482", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644480" ], "products": [ "species_10644471" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10625987": { "compartment": "compartment_70101", "id": "reaction_10625987", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625973" ], "products": [ "species_10625979", "species_10597908" ], "modifiers": [ [ "species_10625984", "catalyst" ] ], "additional_components": [ "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "WBGene00006727", "WBGene00009594" ] }, "reaction_10645210": { "compartment": "compartment_876", "id": "reaction_10645210", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645207" ], "products": [ "species_29370", "species_10645197" ], "modifiers": [ [ "species_10617744", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10657872": { "compartment": "compartment_876", "id": "reaction_10657872", "reactome": "R-CEL-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657866", "species_10657868" ], "products": [ "species_10657870" ], "modifiers": [], "additional_components": [ "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10661671": { "compartment": "compartment_876", "id": "reaction_10661671", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627143", "species_10627117" ], "products": [ "species_10627145" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10655607": { "compartment": "compartment_984", "id": "reaction_10655607", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10655569" ], "products": [ "species_10655571" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10612177": { "compartment": "compartment_70101", "id": "reaction_10612177", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846", "species_112275" ], "products": [ "species_10612175" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644478": { "compartment": "compartment_876", "id": "reaction_10644478", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644467" ], "products": [ "species_10644476" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644474": { "compartment": "compartment_876", "id": "reaction_10644474", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10644471", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10652445": { "compartment": "compartment_876", "id": "reaction_10652445", "reactome": "R-CEL-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652253" ], "products": [ "species_10652443" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421", "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421" ] }, "reaction_10612154": { "compartment": "compartment_70101", "id": "reaction_10612154", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_202277" ], "products": [ "species_10612152" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655611": { "compartment": "compartment_984", "id": "reaction_10655611", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655569", "species_6789198" ], "products": [ "species_10655609" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "species_6789198" ] }, "reaction_10635413": { "compartment": "compartment_876", "id": "reaction_10635413", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10653778": { "compartment": "compartment_6799371", "id": "reaction_10653778", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653746" ], "products": [ "species_10653776" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q18825", "WBGene00000238", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O01824", "WBGene00019008", "O44131", "WBGene00015620", "G5EGP8", "WBGene00000788", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "Q18825", "WBGene00000238", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "G5EGP8", "WBGene00000788" ] }, "reaction_10655577": { "compartment": "compartment_984", "id": "reaction_10655577", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655571" ], "products": [ "species_10655575" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10657844": { "compartment": "compartment_984", "id": "reaction_10657844", "reactome": "R-CEL-8852716", "name": "Thrombin, ELANE cleave C5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607933" ], "products": [ "species_10607947", "species_10657842" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10656550": { "compartment": "compartment_984", "id": "reaction_10656550", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10656546" ], "products": [ "species_10656548" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "species_166005", "O44131", "WBGene00015620" ] }, "reaction_10653606": { "compartment": "compartment_1462052", "id": "reaction_10653606", "reactome": "R-CEL-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653432" ], "products": [ "species_10653604" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760" ] }, "reaction_10628353": { "compartment": "compartment_876", "id": "reaction_10628353", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627119", "species_10627117" ], "products": [ "species_10627121" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10654208": { "compartment": "compartment_1470028", "id": "reaction_10654208", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654040" ], "products": [ "species_10654206" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837", "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837" ] }, "reaction_10627062": { "compartment": "compartment_984", "id": "reaction_10627062", "reactome": "R-CEL-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627056", "species_10627058" ], "products": [ "species_10627060" ], "modifiers": [], "additional_components": [ "WBGene00006619", "WBGene00006619", "Q23528", "WBGene00006619" ] }, "reaction_10637568": { "compartment": "compartment_876", "id": "reaction_10637568", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637562" ], "products": [ "species_29370", "species_10637565" ], "modifiers": [ [ "species_10637562", "catalyst" ] ], "additional_components": [ "WBGene00005077", "WBGene00005077", "WBGene00005077" ] }, "reaction_10663891": { "compartment": "compartment_70101", "id": "reaction_10663891", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638461", "species_8982080" ], "products": [ "species_10663889" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10635404": { "compartment": "compartment_876", "id": "reaction_10635404", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10635401", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256", "G5EDU3", "WBGene00004040" ] }, "reaction_10657864": { "compartment": "compartment_984", "id": "reaction_10657864", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657846" ], "products": [ "species_10657848" ], "modifiers": [ [ "species_10657861", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q9N5D7", "WBGene00020693", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593" ] }, "reaction_10637988": { "compartment": "compartment_984", "id": "reaction_10637988", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607167" ], "products": [ "species_10627129" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10645212": { "compartment": "compartment_876", "id": "reaction_10645212", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10607837" ], "products": [ "species_10645207" ], "modifiers": [], "additional_components": [ "WBGene00003030", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10655475": { "compartment": "compartment_984", "id": "reaction_10655475", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655427" ], "products": [ "species_10655473" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788" ] }, "reaction_10610934": { "compartment": "compartment_876", "id": "reaction_10610934", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610919" ], "products": [ "species_29370", "species_10610931" ], "modifiers": [ [ "species_10610919", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10637560": { "compartment": "compartment_70101", "id": "reaction_10637560", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10637558" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10607959": { "compartment": "compartment_984", "id": "reaction_10607959", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607181" ], "products": [ "species_10607957" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627220": { "compartment": "compartment_876", "id": "reaction_10627220", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607189" ], "products": [ "species_10627119" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627236": { "compartment": "compartment_876", "id": "reaction_10627236", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607167" ], "products": [ "species_10627143" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627155": { "compartment": "compartment_876", "id": "reaction_10627155", "reactome": "R-CEL-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627060", "species_10627151" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627210": { "compartment": "compartment_876", "id": "reaction_10627210", "reactome": "R-CEL-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_10627185", "species_10627060", "species_10627183", "species_10627207" ], "modifiers": [ [ "species_10627153", "catalyst" ] ], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q22328", "WBGene00002976", "Q23528", "WBGene00006619", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10652817": { "compartment": "compartment_6800173", "id": "reaction_10652817", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652705" ], "products": [ "species_10652815" ], "modifiers": [], "additional_components": [ "Q4W5T6", "WBGene00044310", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760", "Q4W5T6", "WBGene00044310", "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760" ] }, "reaction_10635284": { "compartment": "compartment_70101", "id": "reaction_10635284", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635282", "species_113592" ], "products": [ "species_29370", "species_10618297", "species_10617721" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10655079": { "compartment": "compartment_6800424", "id": "reaction_10655079", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655055" ], "products": [ "species_10655077" ], "modifiers": [], "additional_components": [ "Q20684", "WBGene00002265", "Q9U308", "WBGene00002175", "Q20665", "WBGene00255469", "G5EC10", "WBGene00002272", "Q9N4W4", "WBGene00021602", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q19930", "WBGene00017947", "Q22799", "WBGene00001005", "Q9GYK0", "WBGene00015471", "P30628", "WBGene00006768", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "G5EBV4", "WBGene00002273", "Q9XTY9", "WBGene00010993", "Q9XUF4", "WBGene00008203", "Q19833", "WBGene00017837", "G5EDC6", "WBGene00000192", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q17540", "WBGene00015283", "Q21146", "WBGene00019328", "Q53U87", "WBGene00004732", "G5ED34", "WBGene00001007", "O44873", "WBGene00019915", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "Q9N5X7", "WBGene00016423", "G5EFI4", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10607104" ], "products": [ "species_10655831" ], "modifiers": [], "additional_components": [ "WBGene00022627", "species_166005", "Q23365", "WBGene00022627" ] }, "reaction_10654694": { "compartment": "compartment_6799351", "id": "reaction_10654694", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00006633", "P34462", "WBGene00010130", "Q95QY6", "WBGene00022014", "Q95XH1", "WBGene00022077", "P34446", "WBGene00003929", "Q9NCE1", "WBGene00010408", "G5EBK2", "WBGene00014084", "Q22908", "WBGene00016344", "O44186", "WBGene00017996", "G5EC93", "WBGene00022014", "Q21228", "WBGene00018527", "Q19878", "WBGene00009218", "O44616", "WBGene00022014", "Q20707", "WBGene00006630", "Q19983", "WBGene00006634", "Q93323", "WBGene00007903", "O45920", "WBGene00022014", "Q5WRN9", "WBGene00023502", "P83386", "WBGene00018527", "Q9XVM9", "WBGene00006641", "G5EGM1", "WBGene00006987", "G5EC63", "WBGene00013197", "Q1ZXU1", "WBGene00044790", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "G5EFD9", "WBGene00006324", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q23535", "WBGene00006865", "A0A4V0IKG6", "WBGene00007287", "O62466", "WBGene00006631", "Q11114", "WBGene00022014", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491" ] }, "reaction_10639131": { "compartment": "compartment_876", "id": "reaction_10639131", "reactome": "R-CEL-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639108" ], "products": [ "species_10627115", "species_10639128", "species_10639122" ], "modifiers": [ [ "species_10627060", "catalyst" ] ], "additional_components": [ "Q18849", "WBGene00008314", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619" ] }, "reaction_10651831": { "compartment": "compartment_6798757", "id": "reaction_10651831", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651701" ], "products": [ "species_10651829" ], "modifiers": [], "additional_components": [ "P45971", "WBGene00011638", "E5QCE7", "WBGene00001032", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q18276", "WBGene00004995", "X5LV99", "WBGene00019346", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421", "E5QCE7", "WBGene00001032", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "X5LV99", "WBGene00019346", "Q18276", "WBGene00004995", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421" ] }, "reaction_10665782": { "compartment": "compartment_70101", "id": "reaction_10665782", "reactome": "R-CEL-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10607014" ], "products": [ "species_10665780" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "O45418", "WBGene00001431", "species_9678991", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10629435": { "compartment": "compartment_876", "id": "reaction_10629435", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629432", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10629464": { "compartment": "compartment_876", "id": "reaction_10629464", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629461", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10610716": { "compartment": "compartment_876", "id": "reaction_10610716", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609937", "species_10609928" ], "products": [ "species_10609939" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10610718": { "compartment": "compartment_876", "id": "reaction_10610718", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609921", "species_10609926" ], "products": [ "species_10609928" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "P10984", "WBGene00000064", "WBGene00000894", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10666007": { "compartment": "compartment_7660", "id": "reaction_10666007", "reactome": "R-CEL-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10666001" ], "products": [ "species_10665989", "species_427486" ], "modifiers": [ [ "species_10628319", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00001834" ] }, "reaction_10666004": { "compartment": "compartment_70101", "id": "reaction_10666004", "reactome": "R-CEL-9701531", "name": "p-Y705,S727 STAT3 is acetylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10665989" ], "products": [ "species_2485002", "species_10666001" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00000366" ] }, "reaction_10623765": { "compartment": "compartment_876", "id": "reaction_10623765", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623760": { "compartment": "compartment_876", "id": "reaction_10623760", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10621827": { "compartment": "compartment_876", "id": "reaction_10621827", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10621824", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623751": { "compartment": "compartment_876", "id": "reaction_10623751", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623756": { "compartment": "compartment_876", "id": "reaction_10623756", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623767": { "compartment": "compartment_876", "id": "reaction_10623767", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623758": { "compartment": "compartment_876", "id": "reaction_10623758", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10643263": { "compartment": "compartment_70101", "id": "reaction_10643263", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10643259" ], "products": [ "species_10643261" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10663022": { "compartment": "compartment_70101", "id": "reaction_10663022", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663018" ], "products": [ "species_29368", "species_10663016" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185" ] }, "reaction_10663249": { "compartment": "compartment_70101", "id": "reaction_10663249", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643261" ], "products": [ "species_29368", "species_10643259" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185" ] }, "reaction_10663020": { "compartment": "compartment_70101", "id": "reaction_10663020", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10663016" ], "products": [ "species_10663018" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185" ] }, "reaction_10619462": { "compartment": "compartment_876", "id": "reaction_10619462", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_111627" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10619459", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619469": { "compartment": "compartment_876", "id": "reaction_10619469", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_352022", "species_425425", "species_74113" ], "products": [ "species_83910", "species_351626", "species_111627", "species_188972" ], "modifiers": [ [ "species_10619464", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619454": { "compartment": "compartment_876", "id": "reaction_10619454", "reactome": "R-CEL-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10619447", "catalyst" ] ], "additional_components": [ "WBGene00019844" ] }, "reaction_10647253": { "compartment": "compartment_70101", "id": "reaction_10647253", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647189" ], "products": [ "species_10647227", "species_29372" ], "modifiers": [ [ "species_10647250", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10038", "WBGene00006923", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10605081": { "compartment": "compartment_70101", "id": "reaction_10605081", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605072" ], "products": [ "species_29370", "species_10604506" ], "modifiers": [ [ "species_10605078", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10647195": { "compartment": "compartment_7660", "id": "reaction_10647195", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647189" ], "products": [ "species_10647193" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10604479": { "compartment": "compartment_70101", "id": "reaction_10604479", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604463", "species_10604475" ], "products": [ "species_10604477" ], "modifiers": [], "additional_components": [ "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665" ] }, "reaction_10604510": { "compartment": "compartment_70101", "id": "reaction_10604510", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604477" ], "products": [ "species_29370", "species_10604501" ], "modifiers": [ [ "species_10604477", "catalyst" ], [ "species_10604506", "inhibitor" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186" ] }, "reaction_10604522": { "compartment": "compartment_70101", "id": "reaction_10604522", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604501" ], "products": [ "species_10604463", "species_10604499" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10638746": { "compartment": "compartment_70101", "id": "reaction_10638746", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622515" ], "products": [ "species_29370", "species_10622458" ], "modifiers": [ [ "species_10638729", "catalyst" ] ], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "WBGene00003822" ] }, "reaction_10638836": { "compartment": "compartment_7660", "id": "reaction_10638836", "reactome": "R-CEL-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638821", "species_29358" ], "products": [ "species_113582", "species_10638833" ], "modifiers": [ [ "species_10638821", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10662912": { "compartment": "compartment_7660", "id": "reaction_10662912", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10638719" ], "products": [ "species_10638721" ], "modifiers": [], "additional_components": [ "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638742": { "compartment": "compartment_70101", "id": "reaction_10638742", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638731", "species_1250243" ], "products": [ "species_10638729", "species_10601705" ], "modifiers": [ [ "species_10638736", "catalyst" ] ], "additional_components": [ "O45017", "WBGene00020917", "Q21029", "WBGene00003822", "WBGene00003822", "WBGene00020917", "WBGene00003247" ] }, "reaction_10638724": { "compartment": "compartment_7660", "id": "reaction_10638724", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10638705" ], "products": [ "species_159939", "species_10638707" ], "modifiers": [ [ "species_10638721", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638823": { "compartment": "compartment_7660", "id": "reaction_10638823", "reactome": "R-CEL-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638819" ], "products": [ "species_113582", "species_10638821" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10638839": { "compartment": "compartment_7660", "id": "reaction_10638839", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638707", "species_77087" ], "products": [ "species_77502", "species_10638705" ], "modifiers": [ [ "species_10614316", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036" ] }, "reaction_10621550": { "compartment": "compartment_70101", "id": "reaction_10621550", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615234" ], "products": [ "species_10621548" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00005077", "G5EE56", "WBGene00005077", "Q07292", "WBGene00003030" ] }, "reaction_10621571": { "compartment": "compartment_70101", "id": "reaction_10621571", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10621567" ], "products": [ "species_10621569" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10613690": { "compartment": "compartment_70101", "id": "reaction_10613690", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10613687", "catalyst" ] ], "additional_components": [ "species_113531", "G5EED8", "WBGene00006600" ] }, "reaction_10613711": { "compartment": "compartment_70101", "id": "reaction_10613711", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10597831": { "compartment": "compartment_7660", "id": "reaction_10597831", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597827", "species_10597822" ], "products": [ "species_10597829" ], "modifiers": [], "additional_components": [ "WBGene00012935", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158" ] }, "reaction_10630180": { "compartment": "compartment_7660", "id": "reaction_10630180", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10630172" ], "products": [ "species_113582", "species_10630164" ], "modifiers": [ [ "species_10630177", "catalyst" ] ], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10630243": { "compartment": "compartment_7660", "id": "reaction_10630243", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628748" ], "products": [ "species_10630241" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597751": { "compartment": "compartment_7660", "id": "reaction_10597751", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597742", "species_10597721" ], "products": [ "species_10597744" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10605320": { "compartment": "compartment_7660", "id": "reaction_10605320", "reactome": "R-CEL-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10605292" ], "products": [ "species_113550", "species_10605294" ], "modifiers": [ [ "species_10605317", "catalyst" ] ], "additional_components": [ "WBGene00003020", "G5EDT1", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10605322": { "compartment": "compartment_7660", "id": "reaction_10605322", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113" ], "products": [ "species_113656", "species_10597721" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10628796": { "compartment": "compartment_7660", "id": "reaction_10628796", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10628319" ], "products": [ "species_10628794" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "WBGene00001834", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10597837": { "compartment": "compartment_7660", "id": "reaction_10597837", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597829" ], "products": [ "species_10597780", "species_10597835" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00000413", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10630247": { "compartment": "compartment_7660", "id": "reaction_10630247", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628784" ], "products": [ "species_10630245" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10628800": { "compartment": "compartment_7660", "id": "reaction_10628800", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628319", "species_10628784" ], "products": [ "species_10628798" ], "modifiers": [], "additional_components": [ "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10598120": { "compartment": "compartment_7660", "id": "reaction_10598120", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597740", "species_68419" ], "products": [ "species_10597742" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823" ] }, "reaction_10630168": { "compartment": "compartment_7660", "id": "reaction_10630168", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630164", "species_10628773" ], "products": [ "species_10630166" ], "modifiers": [], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "G5EDT1", "WBGene00003020", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10630251": { "compartment": "compartment_7660", "id": "reaction_10630251", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628782" ], "products": [ "species_10630249" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10630239": { "compartment": "compartment_7660", "id": "reaction_10630239", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10630235" ], "products": [ "species_10630237" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10638114": { "compartment": "compartment_7660", "id": "reaction_10638114", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638089" ], "products": [ "species_10638074" ], "modifiers": [ [ "species_10638111", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10641285": { "compartment": "compartment_7660", "id": "reaction_10641285", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10602463" ], "products": [ "species_10641283", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "P62784", "WBGene00001875", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641349": { "compartment": "compartment_7660", "id": "reaction_10641349", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628319" ], "products": [ "species_10638173", "species_10641347" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "WBGene00006706", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641371": { "compartment": "compartment_7660", "id": "reaction_10641371", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628321" ], "products": [ "species_10641369", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641338": { "compartment": "compartment_7660", "id": "reaction_10641338", "reactome": "R-CEL-4615872", "name": "RANBP2 SUMOylates HDAC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641328", "species_10638181" ], "products": [ "species_10638173", "species_10641336" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00001837", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "P55853", "WBGene00004888", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10662809": { "compartment": "compartment_7660", "id": "reaction_10662809", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640202", "species_10638181" ], "products": [ "species_10662801", "species_10638173" ], "modifiers": [ [ "species_10662806", "catalyst" ] ], "additional_components": [ "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "WBGene00006706", "WBGene00010704" ] }, "reaction_10604149": { "compartment": "compartment_70101", "id": "reaction_10604149", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_83910", "species_179743" ], "modifiers": [ [ "species_10604146", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10665056": { "compartment": "compartment_876", "id": "reaction_10665056", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10624695": { "compartment": "compartment_20699", "id": "reaction_10624695", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10624692", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10604142": { "compartment": "compartment_70101", "id": "reaction_10604142", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10610539": { "compartment": "compartment_876", "id": "reaction_10610539", "reactome": "R-CEL-194130", "name": "Transport (influx) of bile salts and acids by OATP-A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192483" ], "products": [ "species_194156" ], "modifiers": [ [ "species_10610536", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10610509": { "compartment": "compartment_876", "id": "reaction_10610509", "reactome": "R-CEL-194079", "name": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10606540": { "compartment": "compartment_70616", "id": "reaction_10606540", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10606537", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10625070": { "compartment": "compartment_876", "id": "reaction_10625070", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10625067", "catalyst" ] ], "additional_components": [ "CHEBI:63836", "species_176496", "species_176501", "CHEBI:63836", "species_176496", "species_176501", "WBGene00018566" ] }, "reaction_10610520": { "compartment": "compartment_876", "id": "reaction_10610520", "reactome": "R-CEL-194083", "name": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10625124": { "compartment": "compartment_876", "id": "reaction_10625124", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10625121", "catalyst" ] ], "additional_components": [ "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346", "Q9XWC5", "WBGene00013499" ] }, "reaction_10625088": { "compartment": "compartment_876", "id": "reaction_10625088", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10625085", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q9XWC5", "WBGene00013499" ] }, "reaction_10604129": { "compartment": "compartment_70101", "id": "reaction_10604129", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10604154": { "compartment": "compartment_70101", "id": "reaction_10604154", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10604131": { "compartment": "compartment_70101", "id": "reaction_10604131", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10625107": { "compartment": "compartment_876", "id": "reaction_10625107", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10625104", "catalyst" ] ], "additional_components": [ "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10624687": { "compartment": "compartment_70101", "id": "reaction_10624687", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10624684", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10604139": { "compartment": "compartment_70101", "id": "reaction_10604139", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_179738" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10604136", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "WBGene00017867" ] }, "reaction_10625065": { "compartment": "compartment_876", "id": "reaction_10625065", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10625062", "catalyst" ] ], "additional_components": [ "CHEBI:15544", "species_879535", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "species_879629", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10604144": { "compartment": "compartment_70101", "id": "reaction_10604144", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10661501": { "compartment": "compartment_70101", "id": "reaction_10661501", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655821" ], "modifiers": [ [ "species_10661496", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00002278" ] }, "reaction_10661452": { "compartment": "compartment_70101", "id": "reaction_10661452", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661444" ], "products": [ "species_29370", "species_10661449" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10655808": { "compartment": "compartment_7660", "id": "reaction_10655808", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655802" ], "products": [ "species_10611220" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611223": { "compartment": "compartment_70101", "id": "reaction_10611223", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10655829": { "compartment": "compartment_70101", "id": "reaction_10655829", "reactome": "R-CEL-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655821", "species_29356" ], "products": [ "species_10611220", "species_10597908" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00001112" ] }, "reaction_10661506": { "compartment": "compartment_70101", "id": "reaction_10661506", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661503", "species_10597908" ], "products": [ "species_10657634" ], "modifiers": [ [ "species_10639898", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10661454": { "compartment": "compartment_13231", "id": "reaction_10661454", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661444" ], "products": [ "species_10661442" ], "modifiers": [ [ "species_10606957", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10636497": { "compartment": "compartment_70101", "id": "reaction_10636497", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10612150" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10611215": { "compartment": "compartment_876", "id": "reaction_10611215", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611003", "species_10610986" ], "products": [ "species_10611005" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10661299": { "compartment": "compartment_7660", "id": "reaction_10661299", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640221", "species_10661293" ], "products": [ "species_10661297" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773" ] }, "reaction_10657264": { "compartment": "compartment_70101", "id": "reaction_10657264", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10657260" ], "products": [ "species_10657262" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10636439": { "compartment": "compartment_70101", "id": "reaction_10636439", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_179856" ], "products": [ "species_10636437" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10636520": { "compartment": "compartment_876", "id": "reaction_10636520", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610889", "species_10604443" ], "products": [ "species_10610891" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10657270": { "compartment": "compartment_70101", "id": "reaction_10657270", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10657262" ], "products": [ "species_29370", "species_10657267", "species_10657260" ], "modifiers": [ [ "species_10657262", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10655800": { "compartment": "compartment_70101", "id": "reaction_10655800", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655794" ], "products": [ "species_10655798" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611007": { "compartment": "compartment_70101", "id": "reaction_10611007", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610986" ], "products": [ "species_29370", "species_10610889" ], "modifiers": [ [ "species_10611000", "catalyst" ], [ "species_10611005", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10657638": { "compartment": "compartment_70101", "id": "reaction_10657638", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657636" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10655818": { "compartment": "compartment_70101", "id": "reaction_10655818", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655811" ], "modifiers": [ [ "species_10655815", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "G5ECY6", "WBGene00000500" ] }, "reaction_10636522": { "compartment": "compartment_70101", "id": "reaction_10636522", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838" ], "products": [ "species_10610986" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10655805": { "compartment": "compartment_7660", "id": "reaction_10655805", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10655798" ], "products": [ "species_10655802", "species_10597874" ], "modifiers": [ [ "species_10648336", "catalyst" ], [ "species_10638301", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00010406", "WBGene00003599" ] }, "reaction_10610912": { "compartment": "compartment_70101", "id": "reaction_10610912", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610891" ], "products": [ "species_29370", "species_10610909", "species_10604443" ], "modifiers": [ [ "species_10610891", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10661311": { "compartment": "compartment_7660", "id": "reaction_10661311", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661303", "species_10661305" ], "products": [ "species_10661309" ], "modifiers": [], "additional_components": [ "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207" ] }, "reaction_10657626": { "compartment": "compartment_70101", "id": "reaction_10657626", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611220" ], "products": [ "species_29370", "species_10657624" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10599349": { "compartment": "compartment_70101", "id": "reaction_10599349", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10599346", "catalyst" ] ], "additional_components": [ "Q9Y041", "WBGene00001843", "species_113531" ] }, "reaction_10599320": { "compartment": "compartment_70101", "id": "reaction_10599320", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10599317", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10599339": { "compartment": "compartment_70101", "id": "reaction_10599339", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10599336", "catalyst" ] ], "additional_components": [ "Q22633", "WBGene00001993", "Q18347", "WBGene00016294", "species_113531", "species_198836" ] }, "reaction_10599369": { "compartment": "compartment_70101", "id": "reaction_10599369", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10599366", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10599359": { "compartment": "compartment_70101", "id": "reaction_10599359", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10599356", "catalyst" ] ], "additional_components": [ "species_29450", "Q18938", "WBGene00001790" ] }, "reaction_10630983": { "compartment": "compartment_70616", "id": "reaction_10630983", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524079", "species_1524072" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10631012": { "compartment": "compartment_12045", "id": "reaction_10631012", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10631010": { "compartment": "compartment_12045", "id": "reaction_10631010", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524069", "species_1500578" ], "products": [ "species_76194", "species_1524081" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10630999": { "compartment": "compartment_70616", "id": "reaction_10630999", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524083" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10630972": { "compartment": "compartment_70616", "id": "reaction_10630972", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_29374", "species_1524072" ], "modifiers": [ [ "species_10630969", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10666115": { "compartment": "compartment_876", "id": "reaction_10666115", "reactome": "R-CEL-9712210", "name": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666095", "species_10666101", "species_9712200" ], "products": [ "species_10666113" ], "modifiers": [], "additional_components": [ "WBGene00001052", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "CHEBI:28837", "CHEBI:16424", "CHEBI:17580", "CHEBI:30772", "pubchem.compound:17356", "CHEBI:86192", "CHEBI:15409", "CHEBI:16731", "CHEBI:45571", "CHEBI:4917", "CHEBI:4918", "species_427486", "pubchem.compound:17072", "CHEBI:36740", "CHEBI:15400", "CHEBI:168721", "CHEBI:5331", "CHEBI:17362", "CHEBI:29452", "CHEBI:30065", "CHEBI:168585", "CHEBI:171895", "CHEBI:28591", "pubchem.compound:228987", "CHEBI:48408", "CHEBI:17447", "pubchem.compound:101330", "species_76328", "CHEBI:61727", "pubchem.compound:8144", "pubchem.compound:181287", "CHEBI:30776", "CHEBI:87362", "pubchem.compound:20499", "pubchem.compound:91604", "CHEBI:37894", "species_6807616", "CHEBI:15399", "pubchem.compound:92979", "pubchem.compound:106997", "CHEBI:28235", "CHEBI:18346", "CHEBI:76306", "CHEBI:34522", "pubchem.compound:61052", "CHEBI:46202", "CHEBI:18224", "CHEBI:30768", "CHEBI:28600", "CHEBI:28484", "CHEBI:30805", "CHEBI:34037", "CHEBI:28857", "CHEBI:67890", "pubchem.compound:64805", "CHEBI:167345", "CHEBI:28878", "CHEBI:89886", "species_29420", "P17343", "WBGene00001679", "CHEBI:4917", "G5ECT6", "WBGene00001682", "Q86ME6", "WBGene00001052", "CHEBI:167345", "V6CLB7", "WBGene00020997", "pubchem.compound:91604", "CHEBI:5331", "CHEBI:16731", "Q7KPV0", "WBGene00001745", "CHEBI:28484" ] }, "reaction_10661541": { "compartment": "compartment_70616", "id": "reaction_10661541", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606780" ], "products": [ "species_10661539" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10623825": { "compartment": "compartment_70101", "id": "reaction_10623825", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10623822", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10622101": { "compartment": "compartment_70101", "id": "reaction_10622101", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10622098", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10650271": { "compartment": "compartment_70101", "id": "reaction_10650271", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10650268", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10655667": { "compartment": "compartment_70101", "id": "reaction_10655667", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6803785" ], "products": [ "species_70106", "species_29370", "species_6803738" ], "modifiers": [ [ "species_10655664", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_6803743", "species_449703", "Q23196", "WBGene00021056" ] }, "reaction_10650281": { "compartment": "compartment_70101", "id": "reaction_10650281", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10641130": { "compartment": "compartment_12045", "id": "reaction_10641130", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10641127", "catalyst" ] ], "additional_components": [ "Q20118", "WBGene00009505", "Q5FC21", "WBGene00044025" ] }, "reaction_10655675": { "compartment": "compartment_70101", "id": "reaction_10655675", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803743", "species_29356" ], "products": [ "species_449701", "species_193473" ], "modifiers": [ [ "species_10655672", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10650263": { "compartment": "compartment_70101", "id": "reaction_10650263", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10650260", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10650289": { "compartment": "compartment_70101", "id": "reaction_10650289", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10650286", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10622051": { "compartment": "compartment_70101", "id": "reaction_10622051", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10622048", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10622373": { "compartment": "compartment_70101", "id": "reaction_10622373", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10622370", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10641138": { "compartment": "compartment_12045", "id": "reaction_10641138", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10622363": { "compartment": "compartment_70101", "id": "reaction_10622363", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10622360", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10622119": { "compartment": "compartment_70101", "id": "reaction_10622119", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10622116", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10620242": { "compartment": "compartment_17938", "id": "reaction_10620242", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10620239", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10650292": { "compartment": "compartment_70101", "id": "reaction_10650292", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10648046": { "compartment": "compartment_7660", "id": "reaction_10648046", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648040" ], "products": [ "species_113582", "species_10648043" ], "modifiers": [ [ "species_10608272", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10625164": { "compartment": "compartment_5460", "id": "reaction_10625164", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625161", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10663595": { "compartment": "compartment_70101", "id": "reaction_10663595", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10642260", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10599553": { "compartment": "compartment_5460", "id": "reaction_10599553", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10599550", "catalyst" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596" ] }, "reaction_10598689": { "compartment": "compartment_70101", "id": "reaction_10598689", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29398" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10599144": { "compartment": "compartment_5460", "id": "reaction_10599144", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29362", "species_113587", "species_113529" ], "modifiers": [ [ "species_10599141", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10655838": { "compartment": "compartment_5460", "id": "reaction_10655838", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113557", "species_113529" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10655835", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10663592": { "compartment": "compartment_5460", "id": "reaction_10663592", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10663589", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10625174": { "compartment": "compartment_70616", "id": "reaction_10625174", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625171", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10622718": { "compartment": "compartment_5462", "id": "reaction_10622718", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10622715", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10599198": { "compartment": "compartment_5460", "id": "reaction_10599198", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10599195", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10612583": { "compartment": "compartment_5460", "id": "reaction_10612583", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599550", "species_113593" ], "products": [ "species_113581", "species_10612567" ], "modifiers": [ [ "species_10612572", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_10612581", "inhibitor" ], [ "species_113557", "inhibitor" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10599555": { "compartment": "compartment_5460", "id": "reaction_10599555", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10649888": { "compartment": "compartment_70101", "id": "reaction_10649888", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10649885", "catalyst" ] ], "additional_components": [ "species_216667", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10615570": { "compartment": "compartment_70101", "id": "reaction_10615570", "reactome": "R-CEL-373875", "name": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29708" ], "products": [ "species_373863", "species_351626" ], "modifiers": [ [ "species_10612981", "catalyst" ] ], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10599832": { "compartment": "compartment_5460", "id": "reaction_10599832", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10599829", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10622720": { "compartment": "compartment_5460", "id": "reaction_10622720", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10599121", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10622730": { "compartment": "compartment_5460", "id": "reaction_10622730", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113600", "species_29376", "species_113529" ], "modifiers": [ [ "species_10622727", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10599154": { "compartment": "compartment_5460", "id": "reaction_10599154", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113588" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10599151", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10625156": { "compartment": "compartment_5460", "id": "reaction_10625156", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10625153", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10663519": { "compartment": "compartment_5460", "id": "reaction_10663519", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612574", "species_9010792" ], "products": [ "species_10612581" ], "modifiers": [], "additional_components": [ "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10663554": { "compartment": "compartment_5460", "id": "reaction_10663554", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10663551", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_109496" ] }, "reaction_10599183": { "compartment": "compartment_5460", "id": "reaction_10599183", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10599180", "catalyst" ] ], "additional_components": [ "Q09508", "WBGene00015391", "O62215", "WBGene00009353", "P41956", "WBGene00003225", "Q09545", "WBGene00006433", "species_113596" ] }, "reaction_10599134": { "compartment": "compartment_5460", "id": "reaction_10599134", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10599131", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10599116": { "compartment": "compartment_5460", "id": "reaction_10599116", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599113", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q93353", "WBGene00007993", "Q20049", "WBGene00009440", "Q93714", "WBGene00009664", "species_266099" ] }, "reaction_10663526": { "compartment": "compartment_5460", "id": "reaction_10663526", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10663523", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10663568": { "compartment": "compartment_70101", "id": "reaction_10663568", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10663565", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10599872": { "compartment": "compartment_70101", "id": "reaction_10599872", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29398" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10629160": { "compartment": "compartment_70101", "id": "reaction_10629160", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353106", "species_29372" ], "products": [ "species_83951", "species_1237165" ], "modifiers": [ [ "species_10629157", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10629140": { "compartment": "compartment_70101", "id": "reaction_10629140", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10629137", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10630115": { "compartment": "compartment_70101", "id": "reaction_10630115", "reactome": "R-CEL-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10629127", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10629150": { "compartment": "compartment_70101", "id": "reaction_10629150", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10629147", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_109496" ] }, "reaction_10607469": { "compartment": "compartment_70616", "id": "reaction_10607469", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10607114", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29420", "species_29370", "species_113592", "species_29438" ] }, "reaction_10607123": { "compartment": "compartment_70616", "id": "reaction_10607123", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607114", "species_166213" ], "products": [ "species_10607116" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10607125": { "compartment": "compartment_70616", "id": "reaction_10607125", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607118" ], "products": [ "species_10607114", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10607121": { "compartment": "compartment_70616", "id": "reaction_10607121", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607116" ], "products": [ "species_10607118" ], "modifiers": [ [ "species_10607116", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10660441": { "compartment": "compartment_7660", "id": "reaction_10660441", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607861", "species_10658641" ], "products": [ "species_10660439" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "WBGene00004393", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393", "P45897", "WBGene00004858" ] }, "reaction_10660437": { "compartment": "compartment_7660", "id": "reaction_10660437", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660433", "species_10658641" ], "products": [ "species_10660435" ], "modifiers": [], "additional_components": [ "WBGene00022518", "WBGene00004393", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393" ] }, "reaction_10648407": { "compartment": "compartment_17951", "id": "reaction_10648407", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_5690520" ], "products": [ "species_193514", "species_5690539" ], "modifiers": [ [ "species_10648404", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10617868": { "compartment": "compartment_17947", "id": "reaction_10617868", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10617695": { "compartment": "compartment_17951", "id": "reaction_10617695", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_389596", "species_389573" ], "products": [ "species_389620", "species_389593", "species_389615" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617827": { "compartment": "compartment_17951", "id": "reaction_10617827", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10617818": { "compartment": "compartment_17951", "id": "reaction_10617818", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10656361": { "compartment": "compartment_17951", "id": "reaction_10656361", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617816": { "compartment": "compartment_17951", "id": "reaction_10617816", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10657324": { "compartment": "compartment_17947", "id": "reaction_10657324", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657320", "species_5690520" ], "products": [ "species_10657322" ], "modifiers": [], "additional_components": [ "Q20507", "WBGene00009818", "Q9XTZ5", "WBGene00007680", "Q20862", "WBGene00018949", "species_164991", "species_5690542", "Q20507", "WBGene00009818", "species_164991", "Q9XTZ5", "WBGene00007680", "species_5690542", "Q20862", "WBGene00018949" ] }, "reaction_10617708": { "compartment": "compartment_17951", "id": "reaction_10617708", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10617705", "catalyst" ] ], "additional_components": [ "species_113531", "O62515", "WBGene00014000" ] }, "reaction_10617674": { "compartment": "compartment_17951", "id": "reaction_10617674", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10617671", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10627078": { "compartment": "compartment_17951", "id": "reaction_10627078", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10627075", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10656358": { "compartment": "compartment_17951", "id": "reaction_10656358", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617698": { "compartment": "compartment_17951", "id": "reaction_10617698", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_6811612", "species_389573" ], "products": [ "species_389569", "species_389620", "species_389593" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617686": { "compartment": "compartment_17951", "id": "reaction_10617686", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10617683", "catalyst" ] ], "additional_components": [ "species_8878387", "Q17474", "WBGene00007143", "species_109496" ] }, "reaction_10650299": { "compartment": "compartment_17951", "id": "reaction_10650299", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10650296", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10656540": { "compartment": "compartment_17951", "id": "reaction_10656540", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10656537", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10613435": { "compartment": "compartment_70101", "id": "reaction_10613435", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331" ], "products": [ "species_10613333", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "Q03206", "ced-10", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10613439": { "compartment": "compartment_70101", "id": "reaction_10613439", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10613333", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10610461": { "compartment": "compartment_13231", "id": "reaction_10610461", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607331" ], "products": [ "species_10607264" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10620307": { "compartment": "compartment_70101", "id": "reaction_10620307", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620302" ], "products": [ "species_10620304", "species_29420" ], "modifiers": [ [ "species_10620302", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681" ] }, "reaction_10620381": { "compartment": "compartment_70101", "id": "reaction_10620381", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620376" ], "products": [ "species_10620378", "species_29420" ], "modifiers": [ [ "species_10620376", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10641401": { "compartment": "compartment_7660", "id": "reaction_10641401", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641391" ], "products": [ "species_10641399", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00019884", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641432": { "compartment": "compartment_7660", "id": "reaction_10641432", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641415" ], "products": [ "species_10641430", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641275": { "compartment": "compartment_7660", "id": "reaction_10641275", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641264" ], "products": [ "species_10638173", "species_10641273" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00020915", "WBGene00006706", "O45012", "WBGene00020915", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638087": { "compartment": "compartment_7660", "id": "reaction_10638087", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638069", "species_10638074" ], "products": [ "species_10638084", "species_164121", "species_113541" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10642632": { "compartment": "compartment_7660", "id": "reaction_10642632", "reactome": "R-CEL-5228508", "name": "RANBP2 SUMOylates PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10641447": { "compartment": "compartment_7660", "id": "reaction_10641447", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641437" ], "products": [ "species_10641445", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006595", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638321": { "compartment": "compartment_7660", "id": "reaction_10638321", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10638318", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10641361": { "compartment": "compartment_7660", "id": "reaction_10641361", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10598194" ], "products": [ "species_10638173", "species_10641359" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003955", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640956": { "compartment": "compartment_7660", "id": "reaction_10640956", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638173" ], "products": [ "species_10640954", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640528": { "compartment": "compartment_7660", "id": "reaction_10640528", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628901" ], "products": [ "species_10640526", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00000366", "P34545", "WBGene00000366", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641199": { "compartment": "compartment_13231", "id": "reaction_10641199", "reactome": "R-CEL-4551649", "name": "RANBP2 SUMOylates RANBP2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641186", "species_10638181" ], "products": [ "species_10641196", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00003795", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q86G90", "WBGene00003795", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10638341": { "compartment": "compartment_13231", "id": "reaction_10638341", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638328", "species_10638181" ], "products": [ "species_10638338", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641300": { "compartment": "compartment_7660", "id": "reaction_10641300", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641290", "species_10638181" ], "products": [ "species_10641298", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640543": { "compartment": "compartment_7660", "id": "reaction_10640543", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640533", "species_10638181" ], "products": [ "species_10640541", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640987": { "compartment": "compartment_7660", "id": "reaction_10640987", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10640977" ], "products": [ "species_10638173", "species_10640985" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001994", "WBGene00006706", "Q8MQ70", "WBGene00001994", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638449": { "compartment": "compartment_7660", "id": "reaction_10638449", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10636923" ], "products": [ "species_10638413", "species_10638173" ], "modifiers": [ [ "species_10638446", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "P55853", "WBGene00004888", "WBGene00006706", "Q9XTV3", "WBGene00010409", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q18237", "WBGene00016151", "G5EG17", "WBGene00010056" ] }, "reaction_10641326": { "compartment": "compartment_70101", "id": "reaction_10641326", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641324" ], "products": [], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10640476": { "compartment": "compartment_70101", "id": "reaction_10640476", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640470" ], "products": [ "species_10640474" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438" ] }, "reaction_10641973": { "compartment": "compartment_20592", "id": "reaction_10641973", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641961" ], "products": [ "species_10641971" ], "modifiers": [ [ "species_10641907", "catalyst" ] ], "additional_components": [ "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10641915": { "compartment": "compartment_876", "id": "reaction_10641915", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612022", "species_10641880" ], "products": [ "species_10641884" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238" ] }, "reaction_10641963": { "compartment": "compartment_876", "id": "reaction_10641963", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639064", "species_10641959" ], "products": [ "species_10641961" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b" ] }, "reaction_10641878": { "compartment": "compartment_876", "id": "reaction_10641878", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641874", "species_10639064" ], "products": [ "species_10641876" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238", "WBGene00000858", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238" ] }, "reaction_10641891": { "compartment": "compartment_876", "id": "reaction_10641891", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641884" ], "products": [ "species_29370", "species_10641886" ], "modifiers": [ [ "species_10641888", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10641913": { "compartment": "compartment_876", "id": "reaction_10641913", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10641907", "species_10641886" ], "products": [ "species_10641911" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238" ] }, "reaction_10640492": { "compartment": "compartment_876", "id": "reaction_10640492", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640488", "species_10640486" ], "products": [ "species_10640490" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10641957": { "compartment": "compartment_20592", "id": "reaction_10641957", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641911" ], "products": [ "species_10618761", "species_10641955" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P90961", "WBGene00020246", "Q9N532", "WBGene00003238" ] }, "reaction_10641882": { "compartment": "compartment_876", "id": "reaction_10641882", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640846", "species_10639064" ], "products": [ "species_10641880" ], "modifiers": [], "additional_components": [ "WBGene00003238", "WBGene00000858", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238" ] }, "reaction_10660033": { "compartment": "compartment_876", "id": "reaction_10660033", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10657991", "species_10658032" ], "products": [ "species_10660031" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q9U2S4", "WBGene00000184", "Q23165", "WBGene00000166", "G5EDJ4", "WBGene00004928", "species_29438" ] }, "reaction_10643599": { "compartment": "compartment_876", "id": "reaction_10643599", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643587" ], "products": [ "species_10643597" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10631246": { "compartment": "compartment_70101", "id": "reaction_10631246", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611990", "species_10611940" ], "products": [ "species_10611992" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10612002": { "compartment": "compartment_876", "id": "reaction_10612002", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611992" ], "products": [ "species_29370", "species_10611999" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10603107": { "compartment": "compartment_7660", "id": "reaction_10603107", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602942" ], "products": [ "species_113582", "species_113550", "species_10602934" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10604747": { "compartment": "compartment_7660", "id": "reaction_10604747", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10603821" ], "products": [ "species_113541", "species_10603858" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664877": { "compartment": "compartment_7660", "id": "reaction_10664877", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602904" ], "products": [ "species_164121", "species_113541", "species_10602904" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602967" ], "products": [ "species_10603821", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602969": { "compartment": "compartment_7660", "id": "reaction_10602969", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602952" ], "products": [ "species_10602967", "species_10602053", "species_10602065", "species_113541", "species_10601970" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602954": { "compartment": "compartment_7660", "id": "reaction_10602954", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602904" ], "products": [ "species_10601975", "species_10602952", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "WBGene00006648", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664879": { "compartment": "compartment_7660", "id": "reaction_10664879", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10602907": { "compartment": "compartment_7660", "id": "reaction_10602907", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_113541", "species_10602904" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10598407": { "compartment": "compartment_70101", "id": "reaction_10598407", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10598404", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10639536": { "compartment": "compartment_70101", "id": "reaction_10639536", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639531" ], "products": [ "species_110096", "species_10639533" ], "modifiers": [ [ "species_10639531", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640276": { "compartment": "compartment_70101", "id": "reaction_10640276", "reactome": "R-CEL-3780994", "name": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10640268" ], "products": [ "species_109402", "species_10640273" ], "modifiers": [ [ "species_10640268", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640292": { "compartment": "compartment_70101", "id": "reaction_10640292", "reactome": "R-CEL-3780997", "name": "PPP1R3C binds to glycogen:GYG2:GYS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639518", "species_10640266" ], "products": [ "species_10640268" ], "modifiers": [], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10665117": { "compartment": "compartment_70101", "id": "reaction_10665117", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10665114", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_109496" ] }, "reaction_10639526": { "compartment": "compartment_70101", "id": "reaction_10639526", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639508" ], "products": [ "species_10639518" ], "modifiers": [ [ "species_10639523", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10639511": { "compartment": "compartment_70101", "id": "reaction_10639511", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639506" ], "products": [ "species_110096", "species_10639508" ], "modifiers": [ [ "species_10639506", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640297": { "compartment": "compartment_70101", "id": "reaction_10640297", "reactome": "R-CEL-3781011", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10640294" ], "products": [ "species_10640282", "species_29372" ], "modifiers": [ [ "species_10640294", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10639516": { "compartment": "compartment_70101", "id": "reaction_10639516", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639513" ], "products": [ "species_110096", "species_10639506" ], "modifiers": [ [ "species_10639513", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10648882": { "compartment": "compartment_70101", "id": "reaction_10648882", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_193132" ], "products": [ "species_70106", "species_29364", "species_193066" ], "modifiers": [ [ "species_10648879", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10666026": { "compartment": "compartment_70101", "id": "reaction_10666026", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10666023", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q23431", "WBGene00014241", "Q19605", "WBGene00009635" ] }, "reaction_10610423": { "compartment": "compartment_70101", "id": "reaction_10610423", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193057" ], "products": [ "species_29366", "species_29460", "species_29356", "species_193132" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10661727": { "compartment": "compartment_70101", "id": "reaction_10661727", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10661724", "catalyst" ] ], "additional_components": [ "Q9N415", "WBGene00006513", "C7FZU5", "WBGene00077771" ] }, "reaction_10610421": { "compartment": "compartment_70101", "id": "reaction_10610421", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10610416", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10622873": { "compartment": "compartment_70101", "id": "reaction_10622873", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10622870", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q19605", "WBGene00009635" ] }, "reaction_10630301": { "compartment": "compartment_984", "id": "reaction_10630301", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630297", "species_1449707" ], "products": [ "species_10630299" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:27584", "CHEBI:17026", "CHEBI:16973", "CHEBI:17650", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "CHEBI:27584", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "CHEBI:17026", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "CHEBI:16973", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:17650" ] }, "reaction_10649574": { "compartment": "compartment_5460", "id": "reaction_10649574", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696835", "species_113563" ], "products": [ "species_113600", "species_5696848", "species_113529" ], "modifiers": [ [ "species_10649571", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610735": { "compartment": "compartment_70101", "id": "reaction_10610735", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196095" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10666029": { "compartment": "compartment_70101", "id": "reaction_10666029", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10659973": { "compartment": "compartment_70101", "id": "reaction_10659973", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10659970" ], "products": [ "species_29370", "species_10659935" ], "modifiers": [ [ "species_10659970", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10666213": { "compartment": "compartment_984", "id": "reaction_10666213", "reactome": "R-CEL-9734070", "name": "Anti-MET recombinant therapeutic antibodies bind MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618556", "species_9734118" ], "products": [ "species_10666211" ], "modifiers": [], "additional_components": [ "WBGene00008711", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "Q9XVQ7", "WBGene00008711", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619" ] }, "reaction_10659977": { "compartment": "compartment_70101", "id": "reaction_10659977", "reactome": "R-CEL-8875482", "name": "CBL recruits CIN85:endophilin to ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10659944" ], "products": [ "species_10659975" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791" ] }, "reaction_10659981": { "compartment": "compartment_70101", "id": "reaction_10659981", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608658", "species_10659975" ], "products": [ "species_10659979" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10659947": { "compartment": "compartment_70101", "id": "reaction_10659947", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10659935" ], "products": [ "species_10659944" ], "modifiers": [ [ "species_10659935", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10604651": { "compartment": "compartment_7660", "id": "reaction_10604651", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604647", "species_10604634" ], "products": [ "species_10604649" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00014066", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604660": { "compartment": "compartment_7660", "id": "reaction_10604660", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_10604649" ], "products": [ "species_10604657" ], "modifiers": [ [ "species_10604649", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10610473": { "compartment": "compartment_70101", "id": "reaction_10610473", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_29366", "species_193707" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610467": { "compartment": "compartment_17951", "id": "reaction_10610467", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610455": { "compartment": "compartment_17951", "id": "reaction_10610455", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10606370": { "compartment": "compartment_70101", "id": "reaction_10606370", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194069", "species_194073" ], "products": [ "species_76194", "species_193416" ], "modifiers": [ [ "species_10606367", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "species_192356", "species_193472", "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10659836": { "compartment": "compartment_70101", "id": "reaction_10659836", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_5357505", "species_10659832" ], "products": [ "species_10659834" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_176655", "species_5357505", "Q21130", "WBGene00010505" ] }, "reaction_10610485": { "compartment": "compartment_70101", "id": "reaction_10610485", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9617026", "species_29364" ], "products": [ "species_29366", "species_193829" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610446": { "compartment": "compartment_70101", "id": "reaction_10610446", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610547": { "compartment": "compartment_876", "id": "reaction_10610547", "reactome": "R-CEL-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10610544", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "WBGene00003407" ] }, "reaction_10610453": { "compartment": "compartment_17951", "id": "reaction_10610453", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193514", "species_193453" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:16525", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610260": { "compartment": "compartment_70101", "id": "reaction_10610260", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610277": { "compartment": "compartment_17951", "id": "reaction_10610277", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193514", "species_193404" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610465": { "compartment": "compartment_70101", "id": "reaction_10610465", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10666209": { "compartment": "compartment_70101", "id": "reaction_10666209", "reactome": "R-CEL-9733973", "name": "Bile salts bind FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643137", "species_194156" ], "products": [ "species_10666205" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274" ] }, "reaction_10610287": { "compartment": "compartment_17951", "id": "reaction_10610287", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10666207": { "compartment": "compartment_70101", "id": "reaction_10666207", "reactome": "R-CEL-9733969", "name": "Bile salts dissociate from FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666205" ], "products": [ "species_10643137", "species_194156" ], "modifiers": [], "additional_components": [ "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274" ] }, "reaction_10610477": { "compartment": "compartment_17951", "id": "reaction_10610477", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610489": { "compartment": "compartment_70101", "id": "reaction_10610489", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610433": { "compartment": "compartment_17951", "id": "reaction_10610433", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_141343" ], "products": [ "species_193514", "species_193451" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10610483": { "compartment": "compartment_70101", "id": "reaction_10610483", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193829" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610463": { "compartment": "compartment_70101", "id": "reaction_10610463", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610324": { "compartment": "compartment_17951", "id": "reaction_10610324", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10659235": { "compartment": "compartment_70101", "id": "reaction_10659235", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_1806234", "species_8868393" ], "modifiers": [ [ "species_10659232", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10606345": { "compartment": "compartment_70101", "id": "reaction_10606345", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_194096" ], "products": [ "species_111294", "species_76577", "species_29356", "species_194073" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "CHEBI:16755", "species_193451", "species_192356", "species_193472", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10659112": { "compartment": "compartment_70101", "id": "reaction_10659112", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10659109", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10610262": { "compartment": "compartment_70101", "id": "reaction_10610262", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610425": { "compartment": "compartment_17951", "id": "reaction_10610425", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10610475": { "compartment": "compartment_70101", "id": "reaction_10610475", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610457": { "compartment": "compartment_17951", "id": "reaction_10610457", "reactome": "R-CEL-193533", "name": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_193403" ], "products": [ "species_192314", "species_193472" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610528": { "compartment": "compartment_876", "id": "reaction_10610528", "reactome": "R-CEL-194121", "name": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610525", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610469": { "compartment": "compartment_70101", "id": "reaction_10610469", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610258": { "compartment": "compartment_17951", "id": "reaction_10610258", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610459": { "compartment": "compartment_17951", "id": "reaction_10610459", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610451": { "compartment": "compartment_17951", "id": "reaction_10610451", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610479": { "compartment": "compartment_70101", "id": "reaction_10610479", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610448": { "compartment": "compartment_17951", "id": "reaction_10610448", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610233": { "compartment": "compartment_70101", "id": "reaction_10610233", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192136" ], "products": [ "species_29366", "species_191980" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610471": { "compartment": "compartment_70101", "id": "reaction_10610471", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193724" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610332": { "compartment": "compartment_17951", "id": "reaction_10610332", "reactome": "R-CEL-192341", "name": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_192339" ], "products": [ "species_192356", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610487": { "compartment": "compartment_70101", "id": "reaction_10610487", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610481": { "compartment": "compartment_70101", "id": "reaction_10610481", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193707" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610552": { "compartment": "compartment_876", "id": "reaction_10610552", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610549", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610264": { "compartment": "compartment_70101", "id": "reaction_10610264", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191980" ], "products": [ "species_29366", "species_192030" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610442": { "compartment": "compartment_70101", "id": "reaction_10610442", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10643250": { "compartment": "compartment_7660", "id": "reaction_10643250", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10616320" ], "products": [ "species_10643248" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "species_176655", "CHEBI:16755", "species_5357505", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908" ] }, "reaction_10610198": { "compartment": "compartment_70101", "id": "reaction_10610198", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10610195", "catalyst" ] ], "additional_components": [ "species_113531", "Q20027", "WBGene00018036" ] }, "reaction_10610250": { "compartment": "compartment_70101", "id": "reaction_10610250", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610444": { "compartment": "compartment_70101", "id": "reaction_10610444", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10614222": { "compartment": "compartment_13231", "id": "reaction_10614222", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605337" ], "products": [ "species_10614220" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10614879": { "compartment": "compartment_7660", "id": "reaction_10614879", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614875", "species_29428" ], "products": [ "species_10614877" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10665078": { "compartment": "compartment_876", "id": "reaction_10665078", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_10665063" ], "products": [ "species_10665076" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838" ] }, "reaction_10649463": { "compartment": "compartment_70101", "id": "reaction_10649463", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10649460", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10665073": { "compartment": "compartment_7660", "id": "reaction_10665073", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665069" ], "products": [ "species_10665071" ], "modifiers": [ [ "species_10607578", "catalyst" ], [ "species_10611037", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "WBGene00002078", "P39745", "WBGene00003401" ] }, "reaction_10661072": { "compartment": "compartment_7660", "id": "reaction_10661072", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10661060" ], "products": [ "species_10661062" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10664151": { "compartment": "compartment_7660", "id": "reaction_10664151", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664147", "species_10664133" ], "products": [ "species_10664149" ], "modifiers": [], "additional_components": [ "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q21187", "WBGene00001441", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9TYU5", "WBGene00007029", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "P34545", "WBGene00000366", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q9N3S7", "WBGene00021636", "Q21187", "WBGene00001441", "Q9TYU5", "WBGene00007029", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066" ] }, "reaction_10611449": { "compartment": "compartment_70101", "id": "reaction_10611449", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_76194", "species_201034" ], "modifiers": [ [ "species_10611446", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9U2F2", "WBGene00012907", "Q23066", "WBGene00020911", "O16992", "WBGene00021002", "G5EG54", "WBGene00008629", "Q9N3N3", "WBGene00021703", "O44619", "WBGene00019644" ] }, "reaction_10643512": { "compartment": "compartment_70101", "id": "reaction_10643512", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643509", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "O01758", "WBGene00000966", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "O16881", "WBGene00000979", "Q19843", "WBGene00000992", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10663480": { "compartment": "compartment_7660", "id": "reaction_10663480", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649873", "species_10663476", "species_10663464" ], "products": [ "species_10663462", "species_10628319", "species_10663478" ], "modifiers": [], "additional_components": [ "G5EF71", "WBGene00003180", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "Q17381", "WBGene00004013", "Q21187", "WBGene00001441", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "P45972", "WBGene00011639", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00011639", "WBGene00001834", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "B7WN96", "WBGene00001251", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XUW7", "WBGene00001311", "P04255", "WBGene00001885", "P28515", "WBGene00001249", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21187", "WBGene00001441", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10644649": { "compartment": "compartment_70101", "id": "reaction_10644649", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10665002": { "compartment": "compartment_7660", "id": "reaction_10665002", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10644961": { "compartment": "compartment_70101", "id": "reaction_10644961", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643550" ], "products": [ "species_10643552" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665085": { "compartment": "compartment_876", "id": "reaction_10665085", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665076" ], "products": [ "species_10665080" ], "modifiers": [], "additional_components": [ "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10665066": { "compartment": "compartment_876", "id": "reaction_10665066", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665058", "species_113592" ], "products": [ "species_29370", "species_10665063" ], "modifiers": [ [ "species_10665058", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838" ] }, "reaction_10666083": { "compartment": "compartment_7660", "id": "reaction_10666083", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661066", "species_1254400" ], "products": [ "species_10661068" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10612137": { "compartment": "compartment_70101", "id": "reaction_10612137", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10612134", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10645853": { "compartment": "compartment_70101", "id": "reaction_10645853", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643186" ], "products": [ "species_10645851" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643570": { "compartment": "compartment_70101", "id": "reaction_10643570", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_30927" ], "products": [ "species_70106", "species_73473", "species_32737" ], "modifiers": [ [ "species_10643567", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10643188": { "compartment": "compartment_70101", "id": "reaction_10643188", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643184" ], "products": [ "species_10643186" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643631": { "compartment": "compartment_70101", "id": "reaction_10643631", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10643628", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "G5EET7", "WBGene00011940", "G5EGA6", "WBGene00010063", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q1XFZ3", "WBGene00000980" ] }, "reaction_10663581": { "compartment": "compartment_7660", "id": "reaction_10663581", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663576", "species_29358" ], "products": [ "species_113582", "species_10663578" ], "modifiers": [ [ "species_10663576", "catalyst" ] ], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10643557": { "compartment": "compartment_70101", "id": "reaction_10643557", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643554", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10644959": { "compartment": "compartment_70101", "id": "reaction_10644959", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_5334816" ], "products": [ "species_10644957" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665037": { "compartment": "compartment_876", "id": "reaction_10665037", "reactome": "R-CEL-9625482", "name": "PTK2 binds activated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10608528" ], "products": [ "species_10665035" ], "modifiers": [], "additional_components": [ "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10665042": { "compartment": "compartment_876", "id": "reaction_10665042", "reactome": "R-CEL-9625487", "name": "PTK2 autophosphorylates downstream of EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10665035" ], "products": [ "species_29370", "species_10665039" ], "modifiers": [ [ "species_10665035", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643533": { "compartment": "compartment_70101", "id": "reaction_10643533", "reactome": "R-CEL-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10643530", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10645837": { "compartment": "compartment_70101", "id": "reaction_10645837", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644957" ], "products": [ "species_10645835" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665044": { "compartment": "compartment_876", "id": "reaction_10665044", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10645083": { "compartment": "compartment_70616", "id": "reaction_10645083", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10645080", "catalyst" ] ], "additional_components": [ "WBGene00000987" ] }, "reaction_10665082": { "compartment": "compartment_7660", "id": "reaction_10665082", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607884" ], "products": [ "species_10611037" ], "modifiers": [ [ "species_10665080", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10633165": { "compartment": "compartment_20699", "id": "reaction_10633165", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633162", "catalyst" ] ], "additional_components": [ "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633271": { "compartment": "compartment_20699", "id": "reaction_10633271", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633120": { "compartment": "compartment_20699", "id": "reaction_10633120", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10633117", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10633297": { "compartment": "compartment_20699", "id": "reaction_10633297", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633160", "species_10633295" ], "products": [ "species_10633162" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183", "WBGene00018076", "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633321": { "compartment": "compartment_20699", "id": "reaction_10633321", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633318", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10633208": { "compartment": "compartment_20699", "id": "reaction_10633208", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633279": { "compartment": "compartment_20699", "id": "reaction_10633279", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633176": { "compartment": "compartment_20699", "id": "reaction_10633176", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10633173", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10666348": { "compartment": "compartment_7660", "id": "reaction_10666348", "reactome": "R-CEL-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597804", "species_10597787" ], "products": [ "species_10597806" ], "modifiers": [], "additional_components": [ "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10597692": { "compartment": "compartment_7660", "id": "reaction_10597692", "reactome": "R-CEL-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597686", "species_10597678" ], "products": [ "species_10597690" ], "modifiers": [], "additional_components": [ "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XX17", "WBGene00012650", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882" ] }, "reaction_10666265": { "compartment": "compartment_7660", "id": "reaction_10666265", "reactome": "R-CEL-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597818", "species_10597806" ], "products": [ "species_10597820" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10666223": { "compartment": "compartment_70101", "id": "reaction_10666223", "reactome": "R-CEL-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666221" ], "products": [ "species_10597674" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10666346": { "compartment": "compartment_7660", "id": "reaction_10666346", "reactome": "R-CEL-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597797", "species_10597792", "species_10597802" ], "products": [ "species_10597804" ], "modifiers": [], "additional_components": [ "WBGene00003158", "WBGene00003156", "WBGene00003159", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158" ] }, "reaction_10666344": { "compartment": "compartment_7660", "id": "reaction_10666344", "reactome": "R-CEL-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597811", "species_10597816" ], "products": [ "species_10597818" ], "modifiers": [], "additional_components": [ "WBGene00003155", "WBGene00003157", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155" ] }, "reaction_10666263": { "compartment": "compartment_7660", "id": "reaction_10666263", "reactome": "R-CEL-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666259", "species_10597674" ], "products": [ "species_10666261" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00012650", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q9XX17", "WBGene00012650", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10612074": { "compartment": "compartment_70101", "id": "reaction_10612074", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612026" ], "products": [ "species_29370", "species_10612049" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10640242": { "compartment": "compartment_70101", "id": "reaction_10640242", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612049" ], "products": [ "species_29370", "species_10611988" ], "modifiers": [ [ "species_10640239", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00002203" ] }, "reaction_10640245": { "compartment": "compartment_70101", "id": "reaction_10640245", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10640232", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10640234": { "compartment": "compartment_70101", "id": "reaction_10640234", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633032", "species_10611988" ], "products": [ "species_10640232" ], "modifiers": [], "additional_components": [ "WBGene00004087", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10605873": { "compartment": "compartment_7660", "id": "reaction_10605873", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605860" ], "products": [ "species_113582", "species_10605864" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10637119": { "compartment": "compartment_70101", "id": "reaction_10637119", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637115" ], "products": [ "species_29370", "species_10637105" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665030": { "compartment": "compartment_70101", "id": "reaction_10665030", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10665018" ], "products": [ "species_10665028" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10664962": { "compartment": "compartment_70101", "id": "reaction_10664962", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602699", "species_10664958" ], "products": [ "species_10664960" ], "modifiers": [], "additional_components": [ "P91457", "WBGene00003793", "Q17602", "WBGene00003800", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10636865": { "compartment": "compartment_1598585", "id": "reaction_10636865", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636850" ], "products": [ "species_29370", "species_10636862" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10665723": { "compartment": "compartment_13231", "id": "reaction_10665723", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665704", "species_10665708" ], "products": [ "species_10665710" ], "modifiers": [], "additional_components": [ "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636955": { "compartment": "compartment_7660", "id": "reaction_10636955", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636925", "species_10636923", "species_10636929" ], "products": [ "species_10636931" ], "modifiers": [], "additional_components": [ "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "WBGene00019953", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665026": { "compartment": "compartment_1598585", "id": "reaction_10665026", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10649915" ], "products": [ "species_10665018", "species_29420" ], "modifiers": [ [ "species_10665023", "catalyst" ] ], "additional_components": [ "species_29420", "O17915", "WBGene00004302", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10665033": { "compartment": "compartment_70101", "id": "reaction_10665033", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665028", "species_29356" ], "products": [ "species_10649915", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10638338", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "species_29420", "O17915", "WBGene00004302", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10638249": { "compartment": "compartment_70101", "id": "reaction_10638249", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638243", "species_10638238" ], "products": [ "species_10638247" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "Q19848", "WBGene00017895", "H2KZB2", "WBGene00021945" ] }, "reaction_10665721": { "compartment": "compartment_70101", "id": "reaction_10665721", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665712", "species_10665717" ], "products": [ "species_10665719" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00021334", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q9BL83", "WBGene00021334", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636984": { "compartment": "compartment_1598585", "id": "reaction_10636984", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10636976", "species_10636931" ], "products": [ "species_10636982" ], "modifiers": [], "additional_components": [ "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q95XZ5", "WBGene00004166", "Q19325", "WBGene00004737", "O17581", "WBGene00003136", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665725": { "compartment": "compartment_70101", "id": "reaction_10665725", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665710", "species_10665699" ], "products": [ "species_10665712" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00016045", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10665728": { "compartment": "compartment_70101", "id": "reaction_10665728", "reactome": "R-CEL-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_10616987" ], "modifiers": [ [ "species_10665712", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636891": { "compartment": "compartment_70101", "id": "reaction_10636891", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636880" ], "products": [ "species_10636888" ], "modifiers": [ [ "species_10636880", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10636964": { "compartment": "compartment_1598585", "id": "reaction_10636964", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636961" ], "products": [ "species_29370", "species_10636850" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10637117": { "compartment": "compartment_70101", "id": "reaction_10637117", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637105", "species_29356" ], "products": [ "species_10637115", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087" ] }, "reaction_10605887": { "compartment": "compartment_7660", "id": "reaction_10605887", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605878", "species_113592" ], "products": [ "species_29370", "species_10605882" ], "modifiers": [ [ "species_10605884", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10665692": { "compartment": "compartment_70101", "id": "reaction_10665692", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625894", "species_10638238" ], "products": [ "species_10665690" ], "modifiers": [], "additional_components": [ "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00021945", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "H2KZB2", "WBGene00021945" ] }, "reaction_10662392": { "compartment": "compartment_17957", "id": "reaction_10662392", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662092", "species_8931885" ], "products": [ "species_10662385", "species_8931884" ], "modifiers": [ [ "species_10662092", "catalyst" ], [ "species_10662390", "catalyst" ] ], "additional_components": [ "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q9XTW2", "WBGene00010356" ] }, "reaction_10616363": { "compartment": "compartment_17938", "id": "reaction_10616363", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616360", "species_113592" ], "products": [ "species_29370", "species_10606983" ], "modifiers": [ [ "species_10612120", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662470": { "compartment": "compartment_70101", "id": "reaction_10662470", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10606953", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607018": { "compartment": "compartment_17938", "id": "reaction_10607018", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606964", "species_113592" ], "products": [ "species_29370", "species_10606968" ], "modifiers": [ [ "species_10606957", "catalyst" ], [ "species_10606997", "catalyst" ], [ "species_10606979", "inhibitor" ], [ "species_10607016", "inhibitor" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10617104": { "compartment": "compartment_70101", "id": "reaction_10617104", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611523" ], "products": [ "species_10611508", "species_29372" ], "modifiers": [ [ "species_10617101", "catalyst" ] ], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460" ] }, "reaction_10607031": { "compartment": "compartment_70101", "id": "reaction_10607031", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601072" ], "products": [ "species_29370", "species_10607028" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "WBGene00012929" ] }, "reaction_10606878": { "compartment": "compartment_17938", "id": "reaction_10606878", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606874", "species_29438" ], "products": [ "species_10606876", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10665764": { "compartment": "compartment_70101", "id": "reaction_10665764", "reactome": "R-CEL-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10607014" ], "products": [ "species_10607016" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10646908": { "compartment": "compartment_17938", "id": "reaction_10646908", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606997" ], "products": [ "species_29370", "species_10646905" ], "modifiers": [ [ "species_10606997", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607048": { "compartment": "compartment_70101", "id": "reaction_10607048", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601231" ], "products": [ "species_29370", "species_10607046" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "WBGene00012929" ] }, "reaction_10646165": { "compartment": "compartment_70101", "id": "reaction_10646165", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606947", "species_10606934" ], "products": [ "species_10606949" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414", "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414" ] }, "reaction_10646899": { "compartment": "compartment_17938", "id": "reaction_10646899", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606983", "species_10606995" ], "products": [ "species_10606997" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10606959": { "compartment": "compartment_70101", "id": "reaction_10606959", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10606955" ], "products": [ "species_10606957" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607041": { "compartment": "compartment_70101", "id": "reaction_10607041", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607036" ], "products": [ "species_29370", "species_10607039" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "WBGene00012929" ] }, "reaction_10646167": { "compartment": "compartment_17938", "id": "reaction_10646167", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606953", "species_10606895" ], "products": [ "species_10606955" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10622209": { "compartment": "compartment_876", "id": "reaction_10622209", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606957" ], "products": [ "species_29370", "species_10606979" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10617095": { "compartment": "compartment_70101", "id": "reaction_10617095", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_10611523" ], "products": [ "species_10617093" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605906", "species_10605890" ], "products": [ "species_10605908" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00004428", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10605914": { "compartment": "compartment_70101", "id": "reaction_10605914", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601533" ], "products": [ "species_10605912", "species_10601331" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00004428" ] }, "reaction_10665593": { "compartment": "compartment_876", "id": "reaction_10665593", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10665590", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EGA7", "WBGene00004311", "Q22875", "WBGene00004929", "species_29438", "Q27497", "WBGene00001747", "P48727", "WBGene00001748" ] }, "reaction_10665461": { "compartment": "compartment_12045", "id": "reaction_10665461", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346" ], "products": [ "species_10607835" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10635276": { "compartment": "compartment_70101", "id": "reaction_10635276", "reactome": "R-CEL-2028735", "name": "AMOT proteins bind WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635239" ], "products": [ "species_10635274" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10647126": { "compartment": "compartment_876", "id": "reaction_10647126", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10647122" ], "products": [ "species_10647124" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017144", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10640339": { "compartment": "compartment_383505", "id": "reaction_10640339", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640317" ], "products": [ "species_10640337" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10658530": { "compartment": "compartment_876", "id": "reaction_10658530", "reactome": "R-CEL-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658515", "species_29356" ], "products": [ "species_10658527", "species_29372" ], "modifiers": [ [ "species_10658515", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10640341": { "compartment": "compartment_876", "id": "reaction_10640341", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10640317" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10609406": { "compartment": "compartment_70101", "id": "reaction_10609406", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10609384", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617376": { "compartment": "compartment_984", "id": "reaction_10617376", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617364" ], "products": [ "species_10617374" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10665529": { "compartment": "compartment_17906", "id": "reaction_10665529", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665523", "species_10625038" ], "products": [ "species_10665527" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P22981", "WBGene00002335", "P41958", "WBGene00000423" ] }, "reaction_10665450": { "compartment": "compartment_12045", "id": "reaction_10665450", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665357" ], "products": [ "species_10665341" ], "modifiers": [ [ "species_10665447", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10646527": { "compartment": "compartment_7660", "id": "reaction_10646527", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646523", "species_10639320" ], "products": [ "species_10646525" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10665525": { "compartment": "compartment_17906", "id": "reaction_10665525", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665507" ], "products": [ "species_10665523" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10647016": { "compartment": "compartment_876", "id": "reaction_10647016", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647013", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "W6RS10", "WBGene00019902", "Q21408", "WBGene00004951", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "C6KRM7", "WBGene00004372", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "E0AHA7", "WBGene00006803", "species_114519", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XWK4", "WBGene00013202", "G5EDB9", "WBGene00004254", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "Q19770", "WBGene00009100", "O18008", "WBGene00021745", "G5EFW3", "WBGene00004855" ] }, "reaction_10611938": { "compartment": "compartment_70101", "id": "reaction_10611938", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610707" ], "products": [ "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10617354": { "compartment": "compartment_20699", "id": "reaction_10617354", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617336" ], "products": [ "species_10617352" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10635617": { "compartment": "compartment_70101", "id": "reaction_10635617", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635613" ], "products": [ "species_10635615" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10642546": { "compartment": "compartment_70101", "id": "reaction_10642546", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642538", "species_113592" ], "products": [ "species_29370", "species_10642543", "species_10620766" ], "modifiers": [ [ "species_10609574", "catalyst" ] ], "additional_components": [ "species_113592", "A0A1I6CMC9", "WBGene00021943", "P10984", "WBGene00000064", "WBGene00021943", "species_113592", "P10984", "WBGene00000064", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10609380": { "compartment": "compartment_876", "id": "reaction_10609380", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609278", "species_10609364" ], "products": [ "species_10609374" ], "modifiers": [ [ "species_10609376", "inhibitor" ], [ "species_10609378", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=9172", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665504": { "compartment": "compartment_876", "id": "reaction_10665504", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647018", "species_9657579" ], "products": [ "species_10647108" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10611822": { "compartment": "compartment_876", "id": "reaction_10611822", "reactome": "R-CEL-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611819" ], "products": [ "species_29370", "species_10611801" ], "modifiers": [ [ "species_10611819", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856" ] }, "reaction_10665991": { "compartment": "compartment_70101", "id": "reaction_10665991", "reactome": "R-CEL-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665979" ], "products": [ "species_10665989" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10643019": { "compartment": "compartment_171062", "id": "reaction_10643019", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602372", "species_10602367" ], "products": [ "species_10602374" ], "modifiers": [], "additional_components": [ "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10639026": { "compartment": "compartment_171062", "id": "reaction_10639026", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638950", "species_10638940", "species_10638945" ], "products": [ "species_10638952" ], "modifiers": [], "additional_components": [ "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "WBGene00003246", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10665465": { "compartment": "compartment_876", "id": "reaction_10665465", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10665981": { "compartment": "compartment_70101", "id": "reaction_10665981", "reactome": "R-CEL-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665977" ], "products": [ "species_10665979" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661675": { "compartment": "compartment_876", "id": "reaction_10661675", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_10642505" ], "products": [ "species_10642524" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10609414": { "compartment": "compartment_70101", "id": "reaction_10609414", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602407" ], "products": [ "species_10609412" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634222": { "compartment": "compartment_876", "id": "reaction_10634222", "reactome": "R-CEL-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10629224" ], "modifiers": [ [ "species_10634211", "catalyst" ], [ "species_10634220", "inhibitor" ], [ "species_10634216", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5082" ] }, "reaction_10664063": { "compartment": "compartment_70101", "id": "reaction_10664063", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10657704": { "compartment": "compartment_70101", "id": "reaction_10657704", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657699", "species_113592" ], "products": [ "species_10657701", "species_29370" ], "modifiers": [ [ "species_10657699", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10639068": { "compartment": "compartment_984", "id": "reaction_10639068", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10639066", "species_10639032" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00003246" ] }, "reaction_10631286": { "compartment": "compartment_876", "id": "reaction_10631286", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631284" ], "products": [ "species_10609280", "species_10612190" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038" ] }, "reaction_10640145": { "compartment": "compartment_70101", "id": "reaction_10640145", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640137" ], "products": [ "species_10640143" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979" ] }, "reaction_10639544": { "compartment": "compartment_7660", "id": "reaction_10639544", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10639320" ], "products": [ "species_10639542" ], "modifiers": [], "additional_components": [ "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "P34545", "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10643280": { "compartment": "compartment_876", "id": "reaction_10643280", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643276" ], "products": [ "species_10643278" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10665545": { "compartment": "compartment_70101", "id": "reaction_10665545", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665533", "species_10645503" ], "products": [ "species_10665537" ], "modifiers": [ [ "species_10665543", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q18268", "WBGene00003966", "pubchem.compound:73292904" ] }, "reaction_10641377": { "compartment": "compartment_70101", "id": "reaction_10641377", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612014", "species_10641373" ], "products": [ "species_10641375" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10635641": { "compartment": "compartment_70101", "id": "reaction_10635641", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10629362" ], "products": [ "species_10635623" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665516": { "compartment": "compartment_70101", "id": "reaction_10665516", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607835" ], "products": [ "species_10665507", "species_29370" ], "modifiers": [ [ "species_10665513", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "species_30991", "H2KYN2", "WBGene00015650" ] }, "reaction_10664691": { "compartment": "compartment_70101", "id": "reaction_10664691", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664678" ], "products": [ "species_29370", "species_10664684" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10648862": { "compartment": "compartment_7660", "id": "reaction_10648862", "reactome": "R-CEL-5692779", "name": "p-S182 MAPKAPK5 phosphorylates FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10648859" ], "modifiers": [ [ "species_10638831", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10648164": { "compartment": "compartment_70101", "id": "reaction_10648164", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648138" ], "products": [ "species_10648129" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10630128": { "compartment": "compartment_876", "id": "reaction_10630128", "reactome": "R-CEL-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10608459" ], "products": [ "species_10630119" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10639653": { "compartment": "compartment_7660", "id": "reaction_10639653", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639649", "species_10639647" ], "products": [ "species_10639318", "species_10639651" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424", "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q20595", "WBGene00006424" ] }, "reaction_10617040": { "compartment": "compartment_70101", "id": "reaction_10617040", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609408", "species_113592" ], "products": [ "species_29370", "species_10617037" ], "modifiers": [ [ "species_10609408", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635629": { "compartment": "compartment_70101", "id": "reaction_10635629", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635623" ], "products": [ "species_10635627" ], "modifiers": [], "additional_components": [ "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10639540": { "compartment": "compartment_7660", "id": "reaction_10639540", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605206", "species_10639320", "species_10605196" ], "products": [ "species_10639538" ], "modifiers": [], "additional_components": [ "WBGene00007110", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00018064", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10665743": { "compartment": "compartment_876", "id": "reaction_10665743", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_9674075" ], "products": [ "species_10617614" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=10368", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10639070": { "compartment": "compartment_20699", "id": "reaction_10639070", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639028" ], "products": [ "species_10639050" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10665520": { "compartment": "compartment_876", "id": "reaction_10665520", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10607835" ], "products": [ "species_10641023" ], "modifiers": [ [ "species_10665507", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10617616": { "compartment": "compartment_70101", "id": "reaction_10617616", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_113592" ], "products": [ "species_29370", "species_10617611" ], "modifiers": [ [ "species_10617609", "catalyst" ], [ "species_10617614", "inhibitor" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10665745": { "compartment": "compartment_876", "id": "reaction_10665745", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609364", "species_9674079" ], "products": [ "species_10609376" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5659", "LigandDisplayForward?ligandId=9175", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5656", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=5890", "LigandDisplayForward?ligandId=7426", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745" ] }, "reaction_10635241": { "compartment": "compartment_70101", "id": "reaction_10635241", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_10635225", "species_29370" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10635635": { "compartment": "compartment_70101", "id": "reaction_10635635", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635631" ], "products": [ "species_10635633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10659092": { "compartment": "compartment_70101", "id": "reaction_10659092", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659088", "species_10622260" ], "products": [ "species_10659090" ], "modifiers": [], "additional_components": [ "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10630135": { "compartment": "compartment_876", "id": "reaction_10630135", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10630132", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10638958": { "compartment": "compartment_20699", "id": "reaction_10638958", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638952" ], "products": [ "species_10638956" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10657399": { "compartment": "compartment_70101", "id": "reaction_10657399", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10625343" ], "products": [ "species_10657396" ], "modifiers": [ [ "species_10625343", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00004829", "WBGene00004829", "WBGene00004829" ] }, "reaction_10631237": { "compartment": "compartment_70101", "id": "reaction_10631237", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10612130" ], "products": [ "species_10612134" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10643283": { "compartment": "compartment_876", "id": "reaction_10643283", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643278" ], "products": [ "species_29370", "species_10618313", "species_10642526" ], "modifiers": [ [ "species_10617742", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10665468": { "compartment": "compartment_876", "id": "reaction_10665468", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837" ], "products": [ "species_10608583" ], "modifiers": [ [ "species_10607837", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10658628": { "compartment": "compartment_984", "id": "reaction_10658628", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617342" ], "products": [ "species_10609394", "species_10609276", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10602377": { "compartment": "compartment_17940", "id": "reaction_10602377", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10617380": { "compartment": "compartment_70101", "id": "reaction_10617380", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10615471" ], "products": [ "species_10617378" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00006410", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q95PX0", "WBGene00006410", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10648160": { "compartment": "compartment_70101", "id": "reaction_10648160", "reactome": "R-CEL-5687121", "name": "p-S MAPKAPK5 phosphorylates HSPB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642534" ], "products": [ "species_29370", "species_10648149" ], "modifiers": [ [ "species_10648157", "catalyst" ] ], "additional_components": [ "WBGene00021943", "WBGene00021943", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10657390": { "compartment": "compartment_70101", "id": "reaction_10657390", "reactome": "R-CEL-8848611", "name": "Phosphorylated PXN recruits the CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636369", "species_10657386" ], "products": [ "species_10657388" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419", "WBGene00016197", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10617078": { "compartment": "compartment_70101", "id": "reaction_10617078", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617074" ], "products": [ "species_10617076" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9NAD6", "WBGene00013111", "Q10656", "WBGene00001184", "Q20977", "WBGene00010251", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10642518": { "compartment": "compartment_876", "id": "reaction_10642518", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617912" ], "products": [ "species_29370", "species_10642515" ], "modifiers": [ [ "species_10642501", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "species_112275", "P34722", "WBGene00006599", "species_74016" ] }, "reaction_10664080": { "compartment": "compartment_70101", "id": "reaction_10664080", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664076", "species_10664058" ], "products": [ "species_10664078" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10646973": { "compartment": "compartment_70101", "id": "reaction_10646973", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10647020": { "compartment": "compartment_876", "id": "reaction_10647020", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646912", "species_10646941" ], "products": [ "species_10647018" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10665548": { "compartment": "compartment_876", "id": "reaction_10665548", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665539" ], "products": [ "species_10642764", "species_10645503", "species_10604898", "species_10607835" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10609386": { "compartment": "compartment_70101", "id": "reaction_10609386", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602421" ], "products": [ "species_10609384" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635677": { "compartment": "compartment_70101", "id": "reaction_10635677", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635266", "species_10612022" ], "products": [ "species_10635675" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q19404", "WBGene00008748" ] }, "reaction_10634132": { "compartment": "compartment_70101", "id": "reaction_10634132", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634129" ], "modifiers": [ [ "species_10627446", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10639322": { "compartment": "compartment_7660", "id": "reaction_10639322", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639318", "species_10611936" ], "products": [ "species_10639320", "species_10628319", "species_10639314" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "WBGene00001979", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00001834", "O02482", "WBGene00006773" ] }, "reaction_10634230": { "compartment": "compartment_876", "id": "reaction_10634230", "reactome": "R-CEL-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10634206" ], "modifiers": [ [ "species_10615184", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10647265": { "compartment": "compartment_876", "id": "reaction_10647265", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647259" ], "products": [ "species_10647263", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ], [ "species_10647209", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "WBGene00003030" ] }, "reaction_10647219": { "compartment": "compartment_876", "id": "reaction_10647219", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647024" ], "products": [ "species_29370", "species_10647217" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10634202": { "compartment": "compartment_876", "id": "reaction_10634202", "reactome": "R-CEL-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10634198" ], "products": [ "species_10634200" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "P24348", "WBGene00002299", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "G5EFK8", "WBGene00008779", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10609417": { "compartment": "compartment_70101", "id": "reaction_10609417", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10609412", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10645710": { "compartment": "compartment_7660", "id": "reaction_10645710", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645706", "species_10611936" ], "products": [ "species_10645708" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "WBGene00001979", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10643579": { "compartment": "compartment_7660", "id": "reaction_10643579", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611936", "species_10643575" ], "products": [ "species_10643577" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00007053", "O61845", "WBGene00007053", "O44326", "WBGene00001979" ] }, "reaction_10646962": { "compartment": "compartment_70101", "id": "reaction_10646962", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635257", "species_10646952" ], "products": [ "species_10646960" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10617360": { "compartment": "compartment_984", "id": "reaction_10617360", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609272", "species_10617356" ], "products": [ "species_10617358" ], "modifiers": [], "additional_components": [ "WBGene00004249", "CHEBI:18137", "CHEBI:17421", "P17139", "WBGene00001263", "CHEBI:18137", "Q9N413", "WBGene00004249", "CHEBI:17421", "P17139", "WBGene00001263" ] }, "reaction_10657409": { "compartment": "compartment_70101", "id": "reaction_10657409", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657402", "species_10605408" ], "products": [ "species_10657404" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10635470": { "compartment": "compartment_70101", "id": "reaction_10635470", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263" ], "products": [ "species_10635468" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10639738": { "compartment": "compartment_7660", "id": "reaction_10639738", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10639703" ], "products": [ "species_77502", "species_10639715" ], "modifiers": [ [ "species_10639735", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "O44447", "WBGene00015330", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "Q10666", "WBGene00004077", "G5EFZ3", "WBGene00012458" ] }, "reaction_10639030": { "compartment": "compartment_20699", "id": "reaction_10639030", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638954", "species_10639016" ], "products": [ "species_10639028" ], "modifiers": [], "additional_components": [ "WBGene00003246", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10642512": { "compartment": "compartment_876", "id": "reaction_10642512", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642509" ], "products": [ "species_29370", "species_10642479" ], "modifiers": [ [ "species_10604441", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10635253": { "compartment": "compartment_70101", "id": "reaction_10635253", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635210" ], "products": [ "species_10635212" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10612216": { "compartment": "compartment_876", "id": "reaction_10612216", "reactome": "R-CEL-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611811", "species_10611783" ], "products": [ "species_10611813" ], "modifiers": [], "additional_components": [ "Q09488", "WBGene00004860", "P50488", "WBGene00000900", "P50488", "WBGene00000900", "Q09488", "WBGene00004860" ] }, "reaction_10635251": { "compartment": "compartment_70101", "id": "reaction_10635251", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_29370", "species_10635248" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10611755": { "compartment": "compartment_7660", "id": "reaction_10611755", "reactome": "R-CEL-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607878", "species_10611751" ], "products": [ "species_10611753" ], "modifiers": [], "additional_components": [ "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EDM7", "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10647134": { "compartment": "compartment_876", "id": "reaction_10647134", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10647124" ], "products": [ "species_10647131" ], "modifiers": [ [ "species_10647124", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10665384": { "compartment": "compartment_20699", "id": "reaction_10665384", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346", "species_200993" ], "products": [ "species_10665366", "species_76194" ], "modifiers": [ [ "species_10665381", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10647164": { "compartment": "compartment_20699", "id": "reaction_10647164", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647160", "species_10646952" ], "products": [ "species_10647162" ], "modifiers": [], "additional_components": [ "WBGene00013457", "WBGene00003030", "Q07292", "WBGene00003030", "Q9U1V1", "WBGene00013457" ] }, "reaction_10639023": { "compartment": "compartment_17963", "id": "reaction_10639023", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639000" ], "products": [ "species_10639016" ], "modifiers": [ [ "species_10639021", "catalyst" ] ], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00010670" ] }, "reaction_10635639": { "compartment": "compartment_70101", "id": "reaction_10635639", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10635263" ], "products": [ "species_10635637" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665440": { "compartment": "compartment_876", "id": "reaction_10665440", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607833", "species_29356" ], "products": [ "species_8848337", "species_10607835" ], "modifiers": [ [ "species_10665433", "catalyst" ], [ "species_10665435", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10639074": { "compartment": "compartment_20699", "id": "reaction_10639074", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638956" ], "products": [ "species_10638954", "species_10638950", "species_10638940" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "WBGene00003246", "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234" ] }, "reaction_10617748": { "compartment": "compartment_70101", "id": "reaction_10617748", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617721", "species_10617742" ], "products": [ "species_10617744", "species_10617746" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10609286": { "compartment": "compartment_876", "id": "reaction_10609286", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10609282" ], "products": [ "species_10609284" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10643316": { "compartment": "compartment_876", "id": "reaction_10643316", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643309" ], "products": [ "species_29370", "species_10643313" ], "modifiers": [ [ "species_10618313", "catalyst" ] ], "additional_components": [ "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10631289": { "compartment": "compartment_876", "id": "reaction_10631289", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609284" ], "products": [ "species_29370", "species_10631284" ], "modifiers": [ [ "species_10609284", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617362": { "compartment": "compartment_70101", "id": "reaction_10617362", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617312" ], "products": [ "species_10617314" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q95XA9", "WBGene00021238", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665502": { "compartment": "compartment_70101", "id": "reaction_10665502", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10634127" ], "products": [ "species_10634220" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686" ] }, "reaction_10648147": { "compartment": "compartment_70101", "id": "reaction_10648147", "reactome": "R-CEL-5687101", "name": "p-T182 MAPKAPK5 phosphorylates FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648136" ], "products": [ "species_29370", "species_10648138" ], "modifiers": [ [ "species_10648144", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647202": { "compartment": "compartment_70101", "id": "reaction_10647202", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647083" ], "products": [ "species_29370", "species_10647199" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10611733": { "compartment": "compartment_70101", "id": "reaction_10611733", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611729", "species_10607715" ], "products": [ "species_10611731" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666054": { "compartment": "compartment_263163", "id": "reaction_10666054", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_29356" ], "products": [ "species_10666051", "species_29372" ], "modifiers": [ [ "species_10666039", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29370", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10630126": { "compartment": "compartment_876", "id": "reaction_10630126", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10630123", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EDP9", "WBGene00000001", "G5EFK8", "WBGene00008779" ] }, "reaction_10646970": { "compartment": "compartment_70101", "id": "reaction_10646970", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646968" ], "products": [ "species_10646912", "species_10635257" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10648126": { "compartment": "compartment_7660", "id": "reaction_10648126", "reactome": "R-CEL-5687088", "name": "PKA phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638817" ], "products": [ "species_113582", "species_10648121" ], "modifiers": [ [ "species_10648123", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "WBGene00002189" ] }, "reaction_10665350": { "compartment": "compartment_12045", "id": "reaction_10665350", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665341", "species_71284" ], "products": [ "species_71285", "species_10665346" ], "modifiers": [ [ "species_10650360", "catalyst" ], [ "species_10665348", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216667", "P91402", "WBGene00019710", "species_216667", "pubchem.compound:6918831", "P91402", "WBGene00019710" ] }, "reaction_10665437": { "compartment": "compartment_876", "id": "reaction_10665437", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10665433" ], "products": [ "species_10665435" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10611834": { "compartment": "compartment_876", "id": "reaction_10611834", "reactome": "R-CEL-201510", "name": "PI3K synthesizes PIP3 downstream of ALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10611831", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10612132": { "compartment": "compartment_70101", "id": "reaction_10612132", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612122", "species_113592" ], "products": [ "species_29370", "species_10612130" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665372": { "compartment": "compartment_876", "id": "reaction_10665372", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665366" ], "products": [ "species_10607833" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10646948": { "compartment": "compartment_876", "id": "reaction_10646948", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10646939" ], "products": [ "species_10646941" ], "modifiers": [ [ "species_10646946", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00004014" ] }, "reaction_10635472": { "compartment": "compartment_70101", "id": "reaction_10635472", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362" ], "products": [ "species_10629366" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10665568": { "compartment": "compartment_876", "id": "reaction_10665568", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10602421" ], "products": [ "species_10665566" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P22981", "WBGene00002335", "species_29438", "G5EDP9", "WBGene00000001" ] }, "reaction_10643318": { "compartment": "compartment_876", "id": "reaction_10643318", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617742", "species_10642526" ], "products": [ "species_10643276" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10664074": { "compartment": "compartment_17906", "id": "reaction_10664074", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664068", "species_10664058" ], "products": [ "species_10664072" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10659203": { "compartment": "compartment_70101", "id": "reaction_10659203", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_113592" ], "products": [ "species_29370", "species_10659200" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10635272": { "compartment": "compartment_70101", "id": "reaction_10635272", "reactome": "R-CEL-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10635239" ], "products": [ "species_10635270" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10609396": { "compartment": "compartment_984", "id": "reaction_10609396", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609392" ], "products": [ "species_10609394", "species_10609268" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10611815": { "compartment": "compartment_13231", "id": "reaction_10611815", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611731" ], "products": [ "species_10611751" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666047": { "compartment": "compartment_263163", "id": "reaction_10666047", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_10666043" ], "products": [ "species_10666045" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "O01501", "WBGene00000871", "Q22895", "WBGene00004780", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "Q19213", "WBGene00006922", "O01501", "WBGene00000871", "Q03206", "ced-10", "Q22895", "WBGene00004780", "Q9BL44", "WBGene00022177", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "species_113592", "Q19213", "WBGene00006922", "Q94124", "WBGene00004287" ] }, "reaction_10611805": { "compartment": "compartment_17941", "id": "reaction_10611805", "reactome": "R-CEL-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611801" ], "products": [ "species_10611803", "species_10611729" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10641382": { "compartment": "compartment_70101", "id": "reaction_10641382", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641375", "species_10597908" ], "products": [ "species_10641379" ], "modifiers": [ [ "species_10641375", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00006727", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10634209": { "compartment": "compartment_876", "id": "reaction_10634209", "reactome": "R-CEL-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10634206" ], "products": [ "species_29370", "species_10629229" ], "modifiers": [ [ "species_10634206", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10648162": { "compartment": "compartment_7660", "id": "reaction_10648162", "reactome": "R-CEL-5687123", "name": "p-S115 MAPKAPK5 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648121" ], "products": [ "species_10648155" ], "modifiers": [], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647274": { "compartment": "compartment_876", "id": "reaction_10647274", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_29356" ], "products": [ "species_29372", "species_10647259" ], "modifiers": [ [ "species_10647271", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00012665" ] }, "reaction_10647211": { "compartment": "compartment_876", "id": "reaction_10647211", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647022", "species_113592" ], "products": [ "species_29370", "species_10647209" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10609410": { "compartment": "compartment_876", "id": "reaction_10609410", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10608501" ], "products": [ "species_10609408" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00005077", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10631282": { "compartment": "compartment_70101", "id": "reaction_10631282", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631254", "species_10597908" ], "products": [ "species_10631279" ], "modifiers": [ [ "species_10631254", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "WBGene00006727", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320" ] }, "reaction_10617626": { "compartment": "compartment_70101", "id": "reaction_10617626", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617621", "species_113592" ], "products": [ "species_29370", "species_10617623" ], "modifiers": [ [ "species_10617621", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665463": { "compartment": "compartment_876", "id": "reaction_10665463", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607827", "species_29420" ], "products": [ "species_10608583" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10639072": { "compartment": "compartment_171062", "id": "reaction_10639072", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639032" ], "products": [ "species_10638945" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10602395": { "compartment": "compartment_876", "id": "reaction_10602395", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602393" ], "products": [ "species_10602228" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10635619": { "compartment": "compartment_70101", "id": "reaction_10635619", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10609403": { "compartment": "compartment_70101", "id": "reaction_10609403", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609398" ], "products": [ "species_29370", "species_10609400" ], "modifiers": [ [ "species_10609398", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634137": { "compartment": "compartment_70101", "id": "reaction_10634137", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634134" ], "modifiers": [ [ "species_10627613", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10665363": { "compartment": "compartment_70101", "id": "reaction_10665363", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665353", "species_2530486" ], "products": [ "species_111294", "species_10665357" ], "modifiers": [ [ "species_10637128", "catalyst" ], [ "species_10665361", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10612224": { "compartment": "compartment_947587", "id": "reaction_10612224", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612218", "species_10611729" ], "products": [ "species_10612222" ], "modifiers": [], "additional_components": [ "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "G5EDS9", "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10630279": { "compartment": "compartment_70101", "id": "reaction_10630279", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10630276", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10647255": { "compartment": "compartment_876", "id": "reaction_10647255", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_10647073" ], "products": [ "species_10647075" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00018218", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10635261": { "compartment": "compartment_70101", "id": "reaction_10635261", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635225", "species_10635257" ], "products": [ "species_10635259" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q19404", "WBGene00008748" ] }, "reaction_10665609": { "compartment": "compartment_876", "id": "reaction_10665609", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607842", "species_10665605" ], "products": [ "species_10665607" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10665535": { "compartment": "compartment_876", "id": "reaction_10665535", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641023" ], "products": [ "species_10665533" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665386": { "compartment": "compartment_70101", "id": "reaction_10665386", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637128", "species_9653479" ], "products": [ "species_10665361" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10664082": { "compartment": "compartment_70101", "id": "reaction_10664082", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10659095": { "compartment": "compartment_70101", "id": "reaction_10659095", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_29356" ], "products": [ "species_10659088", "species_10622802", "species_29372" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664688": { "compartment": "compartment_13231", "id": "reaction_10664688", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664678" ], "products": [ "species_10614393" ], "modifiers": [ [ "species_10664686", "inhibitor" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P41990", "WBGene00000168" ] }, "reaction_10611757": { "compartment": "compartment_7660", "id": "reaction_10611757", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611751" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10665541": { "compartment": "compartment_70101", "id": "reaction_10665541", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642764", "species_10665537" ], "products": [ "species_10665539" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10657393": { "compartment": "compartment_876", "id": "reaction_10657393", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10657388", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10657407": { "compartment": "compartment_70101", "id": "reaction_10657407", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657404" ], "products": [ "species_10657402", "species_10605406", "species_29372" ], "modifiers": [ [ "species_10657404", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "WBGene00010374", "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10641386": { "compartment": "compartment_70101", "id": "reaction_10641386", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641379" ], "products": [ "species_10641373", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10642497": { "compartment": "compartment_70101", "id": "reaction_10642497", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642479" ], "products": [ "species_29370", "species_10642494" ], "modifiers": [ [ "species_10642479", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599" ] }, "reaction_10635268": { "compartment": "compartment_70101", "id": "reaction_10635268", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10658626": { "compartment": "compartment_984", "id": "reaction_10658626", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617340" ], "products": [ "species_10609274", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10666049": { "compartment": "compartment_263163", "id": "reaction_10666049", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10666037" ], "products": [ "species_10666039" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10624150": { "compartment": "compartment_876", "id": "reaction_10624150", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561049", "species_29406" ], "products": [ "species_561075", "species_561078" ], "modifiers": [ [ "species_10624147", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621694": { "compartment": "compartment_984", "id": "reaction_10621694", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10621687", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10621668": { "compartment": "compartment_876", "id": "reaction_10621668", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10621588": { "compartment": "compartment_876", "id": "reaction_10621588", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_374935" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10621585", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10621101": { "compartment": "compartment_876", "id": "reaction_10621101", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621098", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624015": { "compartment": "compartment_876", "id": "reaction_10624015", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10624012", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q23501", "WBGene00003843", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "A0A238UKL7", "WBGene00019408", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10620434": { "compartment": "compartment_876", "id": "reaction_10620434", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10620431", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10621605": { "compartment": "compartment_70101", "id": "reaction_10621605", "reactome": "R-CEL-444007", "name": "GAT1-3 mediate Na+/Cl- dependent GABA transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_188972", "species_74113" ], "products": [ "species_352011", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621602", "catalyst" ] ], "additional_components": [ "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623992": { "compartment": "compartment_876", "id": "reaction_10623992", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10623984", "catalyst" ], [ "species_10623990", "inhibitor" ] ], "additional_components": [ "WBGene00022348", "WBGene00004393" ] }, "reaction_10616675": { "compartment": "compartment_984", "id": "reaction_10616675", "reactome": "R-CEL-379393", "name": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_380873" ], "products": [ "species_159362", "species_83910" ], "modifiers": [ [ "species_10616672", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10616012": { "compartment": "compartment_876", "id": "reaction_10616012", "reactome": "R-CEL-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375468", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_375459" ], "modifiers": [ [ "species_10616009", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_29612", "CHEBI:58045", "CHEBI:16958", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "species_29432", "species_73590", "species_111707", "species_29612", "CHEBI:58045", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "WBGene00004908" ] }, "reaction_10624152": { "compartment": "compartment_876", "id": "reaction_10624152", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621636": { "compartment": "compartment_876", "id": "reaction_10621636", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10621633", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "WBGene00000295" ] }, "reaction_10621682": { "compartment": "compartment_876", "id": "reaction_10621682", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10624222": { "compartment": "compartment_876", "id": "reaction_10624222", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10624219", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621616": { "compartment": "compartment_876", "id": "reaction_10621616", "reactome": "R-CEL-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113", "species_188972" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10611405", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10621045": { "compartment": "compartment_876", "id": "reaction_10621045", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10621042", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10624050": { "compartment": "compartment_876", "id": "reaction_10624050", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621088": { "compartment": "compartment_876", "id": "reaction_10621088", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433138" ], "products": [ "species_83910", "species_76190" ], "modifiers": [ [ "species_10621085", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10615145": { "compartment": "compartment_876", "id": "reaction_10615145", "reactome": "R-CEL-351987", "name": "SLC6A6-mediated uptake of taurine and beta-alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352024", "species_74113", "species_188972" ], "products": [ "species_352019", "species_83910", "species_352022" ], "modifiers": [ [ "species_10615142", "catalyst" ] ], "additional_components": [ "CHEBI:16958", "CHEBI:15891", "species_73590", "CHEBI:15891", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10624048": { "compartment": "compartment_876", "id": "reaction_10624048", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621083": { "compartment": "compartment_876", "id": "reaction_10621083", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433123" ], "products": [ "species_83910", "species_29434" ], "modifiers": [ [ "species_10621080", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10623957": { "compartment": "compartment_876", "id": "reaction_10623957", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622172": { "compartment": "compartment_876", "id": "reaction_10622172", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10621070": { "compartment": "compartment_876", "id": "reaction_10621070", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621067", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624187": { "compartment": "compartment_876", "id": "reaction_10624187", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561071", "species_29406" ], "products": [ "species_561075", "species_561062" ], "modifiers": [ [ "species_10624184", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176496", "species_176501", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10615148": { "compartment": "compartment_876", "id": "reaction_10615148", "reactome": "R-CEL-352029", "name": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_352007" ], "products": [ "species_83910", "species_352022", "species_351982" ], "modifiers": [ [ "species_10611378", "catalyst" ] ], "additional_components": [ "CHEBI:48950", "CHEBI:16958", "species_352003", "species_6798202", "species_73590", "CHEBI:48950", "species_352003", "species_6798202", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623996": { "compartment": "compartment_876", "id": "reaction_10623996", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621631": { "compartment": "compartment_876", "id": "reaction_10621631", "reactome": "R-CEL-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029", "species_74113", "species_188972" ], "products": [ "species_29424", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621628", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10624189": { "compartment": "compartment_876", "id": "reaction_10624189", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621119": { "compartment": "compartment_876", "id": "reaction_10621119", "reactome": "R-CEL-433698", "name": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10621116", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10624243": { "compartment": "compartment_876", "id": "reaction_10624243", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_597604" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10624240", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "WBGene00008273" ] }, "reaction_10615811": { "compartment": "compartment_876", "id": "reaction_10615811", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622170": { "compartment": "compartment_876", "id": "reaction_10622170", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10620466": { "compartment": "compartment_876", "id": "reaction_10620466", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_264618" ], "modifiers": [ [ "species_10620463", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10621677": { "compartment": "compartment_876", "id": "reaction_10621677", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10665294": { "compartment": "compartment_876", "id": "reaction_10665294", "reactome": "R-CEL-9645220", "name": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10665291", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10621114": { "compartment": "compartment_876", "id": "reaction_10621114", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433111" ], "products": [ "species_433124", "species_83910" ], "modifiers": [ [ "species_10621111", "catalyst" ] ], "additional_components": [ "species_29654", "species_1650769", "species_29654", "species_1650769", "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10612194": { "compartment": "compartment_70101", "id": "reaction_10612194", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612187", "species_179856" ], "products": [ "species_10612192" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10612202": { "compartment": "compartment_70101", "id": "reaction_10612202", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10612199", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10625850": { "compartment": "compartment_74700", "id": "reaction_10625850", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10625847", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10625825": { "compartment": "compartment_74700", "id": "reaction_10625825", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10598971": { "compartment": "compartment_5460", "id": "reaction_10598971", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10598968", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10599029": { "compartment": "compartment_5460", "id": "reaction_10599029", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10599026", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10598935": { "compartment": "compartment_5460", "id": "reaction_10598935", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10598932", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57427", "species_29702", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10599039": { "compartment": "compartment_5460", "id": "reaction_10599039", "reactome": "R-CEL-70885", "name": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_573404", "species_113526" ], "products": [ "species_29362", "species_113529", "species_30004" ], "modifiers": [ [ "species_10599036", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10623795": { "compartment": "compartment_5460", "id": "reaction_10623795", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10598958", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10623787": { "compartment": "compartment_70101", "id": "reaction_10623787", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_508182", "species_29406" ], "modifiers": [ [ "species_10598916", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "CHEBI:58045", "CHEBI:57427", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10598991": { "compartment": "compartment_5460", "id": "reaction_10598991", "reactome": "R-CEL-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10598988", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10599011": { "compartment": "compartment_5460", "id": "reaction_10599011", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10599008", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10599001": { "compartment": "compartment_5460", "id": "reaction_10599001", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10599021": { "compartment": "compartment_5460", "id": "reaction_10599021", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10598945": { "compartment": "compartment_5460", "id": "reaction_10598945", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10598942", "catalyst" ] ], "additional_components": [ "species_113596", "G5EEH6", "WBGene00015326" ] }, "reaction_10598908": { "compartment": "compartment_5460", "id": "reaction_10598908", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10598905", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O17953", "WBGene00010794", "O45924", "WBGene00012713", "species_113596" ] }, "reaction_10598981": { "compartment": "compartment_5460", "id": "reaction_10598981", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10598978", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10599047": { "compartment": "compartment_5460", "id": "reaction_10599047", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599044", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10648280": { "compartment": "compartment_70101", "id": "reaction_10648280", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607380" ], "products": [ "species_10607378", "species_10607380" ], "modifiers": [ [ "species_10648277", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10648264": { "compartment": "compartment_7660", "id": "reaction_10648264", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648253", "species_10648260" ], "products": [ "species_10648262" ], "modifiers": [], "additional_components": [ "WBGene00013924", "WBGene00006446", "O17850", "WBGene00006446", "Q23451", "WBGene00013924" ] }, "reaction_10649878": { "compartment": "compartment_7660", "id": "reaction_10649878", "reactome": "R-CEL-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649863" ], "products": [ "species_10649875", "species_10648387" ], "modifiers": [ [ "species_10649863", "catalyst" ] ], "additional_components": [ "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "P0CG71", "WBGene00006727", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249" ] }, "reaction_10649549": { "compartment": "compartment_7660", "id": "reaction_10649549", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649544" ], "products": [ "species_10648387", "species_10649546" ], "modifiers": [ [ "species_10649544", "catalyst" ] ], "additional_components": [ "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10649902": { "compartment": "compartment_7660", "id": "reaction_10649902", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607906", "species_10649898" ], "products": [ "species_10649900" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "P46504", "WBGene00017754", "Q20617", "WBGene00006719", "Q9XVR6", "WBGene00007718", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10659851": { "compartment": "compartment_70101", "id": "reaction_10659851", "reactome": "R-CEL-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659849" ], "products": [ "species_10611220" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00001112" ] }, "reaction_10646598": { "compartment": "compartment_70101", "id": "reaction_10646598", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646587", "species_10646594" ], "products": [ "species_10646596" ], "modifiers": [], "additional_components": [ "WBGene00006724", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q09444", "WBGene00006724", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648301": { "compartment": "compartment_70101", "id": "reaction_10648301", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648297", "species_10646594" ], "products": [ "species_10648299" ], "modifiers": [], "additional_components": [ "WBGene00006856", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "Q17361", "WBGene00006856", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648390": { "compartment": "compartment_7660", "id": "reaction_10648390", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648346" ], "products": [ "species_10648387", "species_10648352" ], "modifiers": [ [ "species_10648346", "catalyst" ] ], "additional_components": [ "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "P0CG71", "WBGene00006727", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912" ] }, "reaction_10649596": { "compartment": "compartment_7660", "id": "reaction_10649596", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649591" ], "products": [ "species_10649593", "species_10648387" ], "modifiers": [ [ "species_10649591", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10658620": { "compartment": "compartment_70101", "id": "reaction_10658620", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648512" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10658617", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00021733" ] }, "reaction_10648492": { "compartment": "compartment_7660", "id": "reaction_10648492", "reactome": "R-CEL-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648487", "species_113518" ], "products": [ "species_10648489", "species_10597874" ], "modifiers": [ [ "species_10648487", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10648531": { "compartment": "compartment_70101", "id": "reaction_10648531", "reactome": "R-CEL-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10648504" ], "products": [ "species_10648506", "species_10648528" ], "modifiers": [ [ "species_10648504", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400" ] }, "reaction_10649660": { "compartment": "compartment_7660", "id": "reaction_10649660", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649653" ], "products": [ "species_10649657", "species_10648387" ], "modifiers": [ [ "species_10649653", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863" ] }, "reaction_10649710": { "compartment": "compartment_70101", "id": "reaction_10649710", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649706", "species_10628847" ], "products": [ "species_10649708" ], "modifiers": [], "additional_components": [ "WBGene00008547", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q19132", "WBGene00008547" ] }, "reaction_10648284": { "compartment": "compartment_7660", "id": "reaction_10648284", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646315", "species_10648260" ], "products": [ "species_10648282" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "P54812", "WBGene00008053", "O17850", "WBGene00006446" ] }, "reaction_10648649": { "compartment": "compartment_70101", "id": "reaction_10648649", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648645", "species_10648641" ], "products": [ "species_10648647" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "O76671", "WBGene00019185", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "Q22038", "WBGene00004357", "P46504", "WBGene00017754", "O76671", "WBGene00019185", "Q9XVR6", "WBGene00007718" ] }, "reaction_10646629": { "compartment": "compartment_70101", "id": "reaction_10646629", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646592", "species_10598108" ], "products": [ "species_10646594" ], "modifiers": [], "additional_components": [ "WBGene00016981", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648625": { "compartment": "compartment_70101", "id": "reaction_10648625", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648616", "species_29356" ], "products": [ "species_10648620", "species_10648622" ], "modifiers": [ [ "species_10648616", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10649635": { "compartment": "compartment_7660", "id": "reaction_10649635", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649630" ], "products": [ "species_10649632", "species_10597874" ], "modifiers": [ [ "species_10649630", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "WBGene00006727", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885" ] }, "reaction_10649701": { "compartment": "compartment_70101", "id": "reaction_10649701", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649694", "species_29356" ], "products": [ "species_10649698", "species_10597908" ], "modifiers": [ [ "species_10649694", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "WBGene00006727", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856" ] }, "reaction_10648584": { "compartment": "compartment_70101", "id": "reaction_10648584", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648579", "species_29356" ], "products": [ "species_1131871", "species_10648581" ], "modifiers": [ [ "species_10648579", "catalyst" ] ], "additional_components": [ "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727" ] }, "reaction_10656887": { "compartment": "compartment_263163", "id": "reaction_10656887", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656855", "species_10656885" ], "products": [ "species_10656865" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10657132": { "compartment": "compartment_263163", "id": "reaction_10657132", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657128" ], "products": [ "species_10657130" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O18230", "WBGene00013302", "Q94392", "WBGene00003818" ] }, "reaction_10656916": { "compartment": "compartment_70101", "id": "reaction_10656916", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656912", "species_10656873" ], "products": [ "species_10656914" ], "modifiers": [], "additional_components": [ "WBGene00010040", "Q20758", "WBGene00000187", "species_29438", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10656741": { "compartment": "compartment_263163", "id": "reaction_10656741", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10656732" ], "products": [ "species_10656738", "species_29420" ], "modifiers": [ [ "species_10656732", "catalyst" ] ], "additional_components": [ "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "species_29438", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656881": { "compartment": "compartment_263163", "id": "reaction_10656881", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656865", "species_10656873" ], "products": [ "species_10656879" ], "modifiers": [], "additional_components": [ "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10656734": { "compartment": "compartment_263163", "id": "reaction_10656734", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656722", "species_10656710" ], "products": [ "species_10656732" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656925": { "compartment": "compartment_70101", "id": "reaction_10656925", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656921", "species_10656873" ], "products": [ "species_10656923" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10656907": { "compartment": "compartment_263163", "id": "reaction_10656907", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656903", "species_10656879" ], "products": [ "species_10656905" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q9N3C8", "WBGene00021841", "Q18013", "WBGene00002220", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10651166": { "compartment": "compartment_7660", "id": "reaction_10651166", "reactome": "R-CEL-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651163", "species_113560" ], "products": [ "species_2485002", "species_10647489" ], "modifiers": [ [ "species_10651163", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647505": { "compartment": "compartment_7660", "id": "reaction_10647505", "reactome": "R-CEL-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647500", "species_113560" ], "products": [ "species_2485002", "species_10647502" ], "modifiers": [ [ "species_10647500", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647494": { "compartment": "compartment_7660", "id": "reaction_10647494", "reactome": "R-CEL-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647489", "species_29358" ], "products": [ "species_113582", "species_10647491", "species_10614888" ], "modifiers": [ [ "species_10647489", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648887": { "compartment": "compartment_7660", "id": "reaction_10648887", "reactome": "R-CEL-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647502", "species_29358" ], "products": [ "species_113582", "species_10648884", "species_10614888" ], "modifiers": [ [ "species_10647502", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10603971": { "compartment": "compartment_5460", "id": "reaction_10603971", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603969": { "compartment": "compartment_5460", "id": "reaction_10603969", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77322" ], "products": [ "species_29362", "species_77320", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603967": { "compartment": "compartment_5460", "id": "reaction_10603967", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10649824": { "compartment": "compartment_7660", "id": "reaction_10649824", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10649819" ], "products": [ "species_10649821", "species_113541" ], "modifiers": [ [ "species_10649819", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823" ] }, "reaction_10649832": { "compartment": "compartment_7660", "id": "reaction_10649832", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649821" ], "products": [ "species_10649830", "species_10648549" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "WBGene00002985" ] }, "reaction_10614353": { "compartment": "compartment_7660", "id": "reaction_10614353", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614344", "species_77087" ], "products": [ "species_77502", "species_10614350" ], "modifiers": [ [ "species_10614344", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9GYS1", "WBGene00003224", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614340": { "compartment": "compartment_7660", "id": "reaction_10614340", "reactome": "R-CEL-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10614318" ], "products": [ "species_10614337", "species_77502" ], "modifiers": [ [ "species_10614318", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614320": { "compartment": "compartment_7660", "id": "reaction_10614320", "reactome": "R-CEL-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10614316" ], "products": [ "species_10614318" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10660998": { "compartment": "compartment_7660", "id": "reaction_10660998", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10638301" ], "products": [ "species_10660996" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00003599", "H2L0K3", "WBGene00003599", "G5EFQ5", "WBGene00004393" ] }, "reaction_10658639": { "compartment": "compartment_7660", "id": "reaction_10658639", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10658633" ], "products": [ "species_10658637" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10666150": { "compartment": "compartment_12045", "id": "reaction_10666150", "reactome": "R-CEL-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10617216" ], "products": [ "species_10617224" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10637461": { "compartment": "compartment_984", "id": "reaction_10637461", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637458", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q19777", "WBGene00009109" ] }, "reaction_10666201": { "compartment": "compartment_876", "id": "reaction_10666201", "reactome": "R-CEL-9728748", "name": "Bitter compound binds bitter taste receptor (TAS2R)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666195", "species_9728981" ], "products": [ "species_10666199" ], "modifiers": [], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "CHEBI:73236", "CHEBI:10093", "CHEBI:9162", "CHEBI:351346", "CHEBI:7789", "LigandDisplayForward?ligandId=5535", "CHEBI:3768", "CHEBI:73226", "CHEBI:5547", "CHEBI:73235", "LigandDisplayForward?ligandId=7074", "CHEBI:2948", "CHEBI:2366", "CHEBI:73222", "CHEBI:44975", "CHEBI:23736", "CHEBI:3941", "pubchem.compound:14217", "CHEBI:8206", "CHEBI:138412", "LigandDisplayForward?ligandId=86", "CHEBI:27641", "pubchem.compound:3032338", "pubchem.compound:19518", "CHEBI:4325", "pubchem.compound:69794", "CHEBI:32111", "CHEBI:3419", "CHEBI:34750", "CHEBI:36773", "CHEBI:73237", "CHEBI:73224", "CHEBI:27613", "CHEBI:2825", "CHEBI:82431", "species_39703", "pubchem.compound:2723704", "CHEBI:42638", "species_76328", "CHEBI:17814", "CHEBI:69441", "species_8855492", "CHEBI:2853", "CHEBI:82346", "CHEBI:28179", "LigandDisplayForward?ligandId=1224", "LigandDisplayForward?ligandId=6976", "CHEBI:26948", "CHEBI:83501", "CHEBI:59039", "CHEBI:46261", "CHEBI:3445", "CHEBI:3944", "CHEBI:28973", "CHEBI:16150", "CHEBI:73232", "CHEBI:18305", "CHEBI:28579", "CHEBI:15854", "CHEBI:3614", "CHEBI:8502", "CHEBI:17698", "pubchem.compound:71648", "CHEBI:69236", "CHEBI:2622", "CHEBI:8692", "CHEBI:4638", "CHEBI:73239", "species_39427", "CHEBI:23359", "CHEBI:28241", "CHEBI:48923", "CHEBI:73228", "CHEBI:17682", "CHEBI:16226", "CHEBI:65408", "CHEBI:7939", "CHEBI:3193", "pubchem.compound:2723593", "species_217315", "CHEBI:27732", "CHEBI:73231", "CHEBI:16962", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678" ] }, "reaction_10666153": { "compartment": "compartment_12045", "id": "reaction_10666153", "reactome": "R-CEL-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10617224", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10660101": { "compartment": "compartment_70101", "id": "reaction_10660101", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_8876310" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10660098", "catalyst" ] ], "additional_components": [ "species_8869604", "species_113557", "species_6807616", "species_197230", "species_113557", "species_6807616", "WBGene00014092" ] }, "reaction_10620062": { "compartment": "compartment_876", "id": "reaction_10620062", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10620059", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10619969": { "compartment": "compartment_876", "id": "reaction_10619969", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10619966", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10645786": { "compartment": "compartment_70101", "id": "reaction_10645786", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10645783", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10618811": { "compartment": "compartment_876", "id": "reaction_10618811", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10618808", "catalyst" ] ], "additional_components": [ "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151", "Q95XP5", "WBGene00003153" ] }, "reaction_10618823": { "compartment": "compartment_114521", "id": "reaction_10618823", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_427899" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10618816", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10619486": { "compartment": "compartment_876", "id": "reaction_10619486", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10619483", "catalyst" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "H2KYP2", "WBGene00003567", "G5EF08", "WBGene00003566", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10618036": { "compartment": "compartment_70101", "id": "reaction_10618036", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618031" ], "products": [ "species_29420", "species_10618033" ], "modifiers": [ [ "species_10618031", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10614196": { "compartment": "compartment_7660", "id": "reaction_10614196", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10614200": { "compartment": "compartment_7660", "id": "reaction_10614200", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10636661": { "compartment": "compartment_70101", "id": "reaction_10636661", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357697", "species_5359016" ], "products": [ "species_5357660", "species_5359011", "species_29432" ], "modifiers": [ [ "species_10636658", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10631233": { "compartment": "compartment_70101", "id": "reaction_10631233", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10631230", "catalyst" ] ], "additional_components": [ "Q22820", "WBGene00000515", "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631053": { "compartment": "compartment_12045", "id": "reaction_10631053", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10631050", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "O44732", "WBGene00018797", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631200": { "compartment": "compartment_12045", "id": "reaction_10631200", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10631197", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10649500": { "compartment": "compartment_5460", "id": "reaction_10649500", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696414" ], "products": [ "species_113548", "species_5693978", "species_113532" ], "modifiers": [ [ "species_10649497", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10631211": { "compartment": "compartment_12045", "id": "reaction_10631211", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10631208", "catalyst" ] ], "additional_components": [ "Q9XXT5", "WBGene00010425", "species_109496" ] }, "reaction_10649269": { "compartment": "compartment_12045", "id": "reaction_10649269", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612768", "species_10612734" ], "products": [ "species_10612770" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "G5EDE8", "WBGene00002070", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q22170", "WBGene00002071" ] }, "reaction_10649279": { "compartment": "compartment_12045", "id": "reaction_10649279", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612677", "species_10612714" ], "products": [ "species_10612716" ], "modifiers": [], "additional_components": [ "WBGene00011648", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615" ] }, "reaction_10657200": { "compartment": "compartment_6791047", "id": "reaction_10657200", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657195" ], "products": [ "species_10649098", "species_10657193" ], "modifiers": [ [ "species_10657195", "catalyst" ] ], "additional_components": [ "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "species_29420", "Q9UAQ6", "WBGene00004266", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649271": { "compartment": "compartment_13959", "id": "reaction_10649271", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649098", "species_10612881", "species_10649147" ], "products": [ "species_10649149" ], "modifiers": [], "additional_components": [ "species_29420", "Q9UAQ6", "WBGene00004266", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "O02173", "WBGene00021046", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649264": { "compartment": "compartment_6791047", "id": "reaction_10649264", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10649260" ], "products": [ "species_10649262" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10612886": { "compartment": "compartment_13959", "id": "reaction_10612886", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612785" ], "products": [ "species_10612883", "species_10612622", "species_10612781", "species_29372", "species_10612881" ], "modifiers": [ [ "species_10612785", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "WBGene00022678", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10657197": { "compartment": "compartment_6791047", "id": "reaction_10657197", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10657193" ], "products": [ "species_10657195" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649386": { "compartment": "compartment_12045", "id": "reaction_10649386", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612772", "species_10612652", "species_10612904" ], "products": [ "species_10612774" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10612896": { "compartment": "compartment_70101", "id": "reaction_10612896", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10612888" ], "products": [ "species_10612652", "species_29420" ], "modifiers": [ [ "species_10612893", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "species_29438", "Q23445", "WBGene00022678", "WBGene00010496" ] }, "reaction_10649171": { "compartment": "compartment_12045", "id": "reaction_10649171", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612898", "species_10612598", "species_10612670" ], "products": [ "species_10649169" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853" ] }, "reaction_10649345": { "compartment": "compartment_6791047", "id": "reaction_10649345", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649252", "species_10649277" ], "products": [ "species_10649343", "species_10649179", "species_10649260", "species_10649186" ], "modifiers": [], "additional_components": [ "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "G5EGG0", "WBGene00010713" ] }, "reaction_10649267": { "compartment": "compartment_6791047", "id": "reaction_10649267", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10649262" ], "products": [ "species_10649229", "species_10649241", "species_10649213", "species_10649258", "species_10649250", "species_10649236", "species_29372", "species_10649234" ], "modifiers": [ [ "species_10649262", "catalyst" ] ], "additional_components": [ "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00009654", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "Q9TXZ9", "WBGene00015164", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "WBGene00007128", "WBGene00043064", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10649156": { "compartment": "compartment_13959", "id": "reaction_10649156", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649149", "species_29438" ], "products": [ "species_10649153", "species_29420" ], "modifiers": [ [ "species_10649149", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649194": { "compartment": "compartment_20699", "id": "reaction_10649194", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649179", "species_10649153", "species_10649186" ], "products": [ "species_10649192" ], "modifiers": [], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "G5EGG0", "WBGene00010713", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649173": { "compartment": "compartment_12045", "id": "reaction_10649173", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774", "species_10612622", "species_10612781" ], "products": [ "species_10612783" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649389": { "compartment": "compartment_70101", "id": "reaction_10649389", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774" ], "products": [ "species_10612772", "species_10612888", "species_29372", "species_10612904" ], "modifiers": [ [ "species_10612774", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29420", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649167": { "compartment": "compartment_12045", "id": "reaction_10649167", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612664", "species_10612670", "species_10612666" ], "products": [ "species_10612672" ], "modifiers": [], "additional_components": [ "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "WBGene00004754", "WBGene00004755", "Q19371", "WBGene00004755", "Q20797", "WBGene00006373", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128" ] }, "reaction_10618547": { "compartment": "compartment_876", "id": "reaction_10618547", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618543", "species_10618528" ], "products": [ "species_10618545" ], "modifiers": [], "additional_components": [ "Q966F9", "WBGene00000071", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q966F9", "WBGene00000071" ] }, "reaction_10618534": { "compartment": "compartment_876", "id": "reaction_10618534", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10618532": { "compartment": "compartment_876", "id": "reaction_10618532", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618530" ], "products": [ "species_10618522", "species_10618528" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618540": { "compartment": "compartment_876", "id": "reaction_10618540", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618538" ], "products": [ "species_10618530", "species_29420" ], "modifiers": [ [ "species_10616742", "catalyst" ] ], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10664419": { "compartment": "compartment_17963", "id": "reaction_10664419", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9033793", "species_205689" ], "modifiers": [ [ "species_10664416", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664437": { "compartment": "compartment_17963", "id": "reaction_10664437", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_9037036", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10656475": { "compartment": "compartment_7660", "id": "reaction_10656475", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10656463" ], "products": [ "species_113582", "species_10656472" ], "modifiers": [ [ "species_10656463", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657117": { "compartment": "compartment_7660", "id": "reaction_10657117", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_29470", "species_29358", "species_113562", "species_10657112" ], "products": [ "species_10657114" ], "modifiers": [ [ "species_10657112", "catalyst" ], [ "species_10657112", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994" ] }, "reaction_10656512": { "compartment": "compartment_7660", "id": "reaction_10656512", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599971", "species_10656465" ], "products": [ "species_10656463" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "Q7YTH5", "WBGene00006390", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "P91868", "WBGene00001568", "G5EG47", "WBGene00010054", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657106": { "compartment": "compartment_7660", "id": "reaction_10657106", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657090" ], "products": [ "species_10657098", "species_10657092" ], "modifiers": [ [ "species_10657090", "catalyst" ], [ "species_10657104", "catalyst" ], [ "species_10600765", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "species_430042", "Q966L5", 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"H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "WBGene00020480", "WBGene00020092" ] }, "reaction_10657202": { "compartment": "compartment_7660", "id": "reaction_10657202", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610160", "species_10600248", "species_10657114", "species_10599886" ], "products": [ "species_10657090" ], "modifiers": [], "additional_components": [ "WBGene00022192", "WBGene00017085", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085" ] }, "reaction_10656510": { "compartment": "compartment_7660", "id": "reaction_10656510", "reactome": "R-CEL-6810235", "name": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656480", "species_10656472", "species_10656504", "species_10656498" ], "products": [ "species_10656508" ], "modifiers": [], "additional_components": [ "WBGene00011143", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "A5Z2V1", "WBGene00009451", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10640732": { "compartment": "compartment_70101", "id": "reaction_10640732", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640717" ], "products": [ "species_29370", "species_10640729" ], "modifiers": [ [ "species_10640717", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640614": { "compartment": "compartment_876", "id": "reaction_10640614", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640606", "species_179856" ], "products": [ "species_10640608" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532" ] }, "reaction_10640600": { "compartment": "compartment_70101", "id": "reaction_10640600", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640597", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95YD4", "WBGene00002213", "Q19475", "WBGene00001164", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10640694": { "compartment": "compartment_70101", "id": "reaction_10640694", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640690", "species_10640684" ], "products": [ "species_10640692" ], "modifiers": [], "additional_components": [ "WBGene00008805", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640702": { "compartment": "compartment_876", "id": "reaction_10640702", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613333", "species_10617725" ], "products": [ "species_10640700" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q17850", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640833": { "compartment": "compartment_70101", "id": "reaction_10640833", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640743", "species_10613352" ], "products": [ "species_10640745" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "WBGene00015704", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640998": { "compartment": "compartment_876", "id": "reaction_10640998", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640991" ], "products": [ "species_10640996" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10640764": { "compartment": "compartment_70101", "id": "reaction_10640764", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621901", "species_113592" ], "products": [ "species_29370", "species_10622006" ], "modifiers": [ [ "species_10640729", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640612": { "compartment": "compartment_876", "id": "reaction_10640612", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10633823", "species_10640608" ], "products": [ "species_10640610" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "Q19475", "WBGene00001164", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "O61861", "WBGene00000205", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10640761": { "compartment": "compartment_876", "id": "reaction_10640761", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331", "species_10640711" ], "products": [ "species_10640713", "species_114549" ], "modifiers": [ [ "species_10640711", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640709": { "compartment": "compartment_70101", "id": "reaction_10640709", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640700" ], "products": [ "species_29370", "species_10640706" ], "modifiers": [ [ "species_10640700", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640753": { "compartment": "compartment_70101", "id": "reaction_10640753", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640745", "species_113592" ], "products": [ "species_29370", "species_10640750" ], "modifiers": [ [ "species_10640745", "catalyst" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640994": { "compartment": "compartment_876", "id": "reaction_10640994", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640750", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640758": { "compartment": "compartment_70101", "id": "reaction_10640758", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608729", "species_10640692" ], "products": [ "species_10640711" ], "modifiers": [], "additional_components": [ "WBGene00010776", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640766": { "compartment": "compartment_70101", "id": "reaction_10640766", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640715", "species_10640713" ], "products": [ "species_10640717" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640841": { "compartment": "compartment_876", "id": "reaction_10640841", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640838", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q965J0", "WBGene00019487", "Q19475", "WBGene00001164" ] }, "reaction_10665741": { "compartment": "compartment_7660", "id": "reaction_10665741", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606498", "species_10665737" ], "products": [ "species_10665739" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "O17919", "WBGene00010478", "Q9TYM6", "WBGene00021655" ] }, "reaction_10642188": { "compartment": "compartment_12045", "id": "reaction_10642188", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642180" ], "products": [ "species_10642077" ], "modifiers": [ [ "species_10642185", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00010757" ] }, "reaction_10625508": { "compartment": "compartment_17963", "id": "reaction_10625508", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625506", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625528": { "compartment": "compartment_17963", "id": "reaction_10625528", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625526", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625518": { "compartment": "compartment_17963", "id": "reaction_10625518", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_205687", "species_10625516" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10634243": { "compartment": "compartment_17963", "id": "reaction_10634243", "reactome": "R-CEL-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625526" ], "products": [ "species_10634238", "species_205687" ], "modifiers": [ [ "species_10634240", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10625644": { "compartment": "compartment_17963", "id": "reaction_10625644", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625415" ], "products": [ "species_205687", "species_10625642" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625551": { "compartment": "compartment_20699", "id": "reaction_10625551", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_205687", "species_10625536" ], "modifiers": [ [ "species_10625548", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q20575", "WBGene00009849", "Q19421", "WBGene00008766" ] }, "reaction_10625655": { "compartment": "compartment_20699", "id": "reaction_10625655", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625536", "species_914003" ], "products": [ "species_205687", "species_10625652" ], "modifiers": [ [ "species_10625601", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10642136": { "compartment": "compartment_12045", "id": "reaction_10642136", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10642077" ], "products": [ "species_158602", "species_10642128" ], "modifiers": [ [ "species_10642133", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00022576" ] }, "reaction_10625634": { "compartment": "compartment_17963", "id": "reaction_10625634", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625559", "species_914003" ], "products": [ "species_10625567", "species_205687" ], "modifiers": [ [ "species_10625631", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641", "G5EBK7", "WBGene00001644", "G5ECK8", "WBGene00001626", "G5EEZ8", "WBGene00001640", "O02315", "WBGene00001642" ] }, "reaction_10625482": { "compartment": "compartment_20699", "id": "reaction_10625482", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625407" ], "products": [ "species_205687", "species_10625415" ], "modifiers": [ [ "species_10625479", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34678", "WBGene00001628", "Q9U2C4", "WBGene00012934", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "O45293", "WBGene00001633", "Q7K755", "WBGene00001636", "O45947", "WBGene00001635", "O61397", "WBGene00001632" ] }, "reaction_10634322": { "compartment": "compartment_20699", "id": "reaction_10634322", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_10625559", "species_205687" ], "modifiers": [ [ "species_10634319", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "O17747", "WBGene00021403", "O17053", "WBGene00021403", "O45579", "WBGene00021403", "O44563", "WBGene00044620", "G5ECT3", "WBGene00021403", "Q22900", "WBGene00021403", "O18184", "WBGene00021403", "Q18515", "WBGene00021403", "O16535", "WBGene00021403", "P41881", "WBGene00021403" ] }, "reaction_10629081": { "compartment": "compartment_24339", "id": "reaction_10629081", "reactome": "R-CEL-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629043" ], "products": [ "species_10629079" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629007": { "compartment": "compartment_171043", "id": "reaction_10629007", "reactome": "R-CEL-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629005" ], "products": [ "species_1236715", "species_10629003" ], "modifiers": [], "additional_components": [ "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629097": { "compartment": "compartment_21994", "id": "reaction_10629097", "reactome": "R-CEL-1236956", "name": "Engulfment of particulate antigen into phagocytic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629089" ], "products": [ "species_10629095", "species_1236714" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10629101": { "compartment": "compartment_70101", "id": "reaction_10629101", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10629083": { "compartment": "compartment_24339", "id": "reaction_10629083", "reactome": "R-CEL-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629079" ], "products": [ "species_10629005" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629099": { "compartment": "compartment_876", "id": "reaction_10629099", "reactome": "R-CEL-1236958", "name": "Interaction of particulate antigens with dendritic cell receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236726", "species_10629087" ], "products": [ "species_10629089" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10649526": { "compartment": "compartment_12045", "id": "reaction_10649526", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10631021": { "compartment": "compartment_12045", "id": "reaction_10631021", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10631018", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910", "Q9NCE1", "WBGene00010408" ] }, "reaction_10630954": { "compartment": "compartment_12045", "id": "reaction_10630954", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657376": { "compartment": "compartment_12045", "id": "reaction_10657376", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10657373", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10630989": { "compartment": "compartment_12045", "id": "reaction_10630989", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630956": { "compartment": "compartment_12045", "id": "reaction_10630956", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630975": { "compartment": "compartment_12045", "id": "reaction_10630975", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500594", "species_29356" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10636052": { "compartment": "compartment_70101", "id": "reaction_10636052", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_265283" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636055": { "compartment": "compartment_70101", "id": "reaction_10636055", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636060": { "compartment": "compartment_70101", "id": "reaction_10636060", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10636057", "catalyst" ] ], "additional_components": [ "Q09596", "WBGene00001753", "species_29450" ] }, "reaction_10614716": { "compartment": "compartment_70101", "id": "reaction_10614716", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10614713", "catalyst" ] ], "additional_components": [ "Q23280", "WBGene00022599", "Q21925", "WBGene00011239" ] }, "reaction_10661537": { "compartment": "compartment_70616", "id": "reaction_10661537", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10661534", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661604": { "compartment": "compartment_70616", "id": "reaction_10661604", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661580", "species_10661578" ], "products": [ "species_10661582" ], "modifiers": [], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10662558": { "compartment": "compartment_70616", "id": "reaction_10662558", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523", "species_10661513", "species_10661532", "species_10661518", "species_10661511" ], "products": [ "species_10661534" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00019296", "Q18874", "WBGene00008345", "WBGene00013462", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661609": { "compartment": "compartment_70616", "id": "reaction_10661609", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949220", "species_2889072" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10661606", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10661599": { "compartment": "compartment_70616", "id": "reaction_10661599", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661582" ], "products": [ "species_10661523", "species_10661578", "species_10661584" ], "modifiers": [ [ "species_10661596", "catalyst" ] ], "additional_components": [ "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "Q23295", "WBGene00013880", "Q95XN2", "WBGene00022159" ] }, "reaction_10661602": { "compartment": "compartment_70616", "id": "reaction_10661602", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523" ], "products": [], "modifiers": [ [ "species_10661578", "catalyst" ] ], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10601291": { "compartment": "compartment_70101", "id": "reaction_10601291", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601287", "species_10601248" ], "products": [ "species_10601289" ], "modifiers": [], "additional_components": [ "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560" ] }, "reaction_10601565": { "compartment": "compartment_70101", "id": "reaction_10601565", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601289" ], "products": [ "species_10601199", "species_10601287", "species_29420" ], "modifiers": [ [ "species_10601287", "catalyst" ] ], "additional_components": [ "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950" ] }, "reaction_10603965": { "compartment": "compartment_5460", "id": "reaction_10603965", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603963": { "compartment": "compartment_5460", "id": "reaction_10603963", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77251", "species_113526" ], "products": [ "species_73871", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10644252": { "compartment": "compartment_876", "id": "reaction_10644252", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644249", "catalyst" ] ], "additional_components": [ "A0A4V0IK35", "WBGene00015867", "O45313", "WBGene00008307", "Q95XD1", "WBGene00022240", "O16638", "WBGene00021116" ] }, "reaction_10664085": { "compartment": "compartment_70101", "id": "reaction_10664085", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664090": { "compartment": "compartment_70101", "id": "reaction_10664090", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_9020474", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10618717": { "compartment": "compartment_876", "id": "reaction_10618717", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618713" ], "products": [ "species_10618715" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10618705": { "compartment": "compartment_984", "id": "reaction_10618705", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618695" ], "products": [ "species_10618703" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10621227": { "compartment": "compartment_876", "id": "reaction_10621227", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621223", "species_10621215" ], "products": [ "species_10621225" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615528": { "compartment": "compartment_876", "id": "reaction_10615528", "reactome": "R-CEL-373746", "name": "SEMA4D interacts with CD45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615507", "species_10615524" ], "products": [ "species_10615526" ], "modifiers": [], "additional_components": [ "WBGene00009401", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q20019", "WBGene00009401" ] }, "reaction_10604168": { "compartment": "compartment_7660", "id": "reaction_10604168", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601975", "species_10601970", "species_10602616" ], "products": [ "species_10602618" ], "modifiers": [], "additional_components": [ "WBGene00006648", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10602624": { "compartment": "compartment_7660", "id": "reaction_10602624", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602065", "species_10602620" ], "products": [ "species_10602622" ], "modifiers": [], "additional_components": [ "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604166": { "compartment": "compartment_7660", "id": "reaction_10604166", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10602053" ], "products": [ "species_10602616" ], "modifiers": [], "additional_components": [ "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10604170": { "compartment": "compartment_7660", "id": "reaction_10604170", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599973", "species_10602618" ], "products": [ "species_10602620" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604172": { "compartment": "compartment_7660", "id": "reaction_10604172", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602622", "species_10601853" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10630113": { "compartment": "compartment_876", "id": "reaction_10630113", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10630110", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10629838": { "compartment": "compartment_876", "id": "reaction_10629838", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629835", "catalyst" ] ], "additional_components": [ "Q21529", "WBGene00006658", "P90863", "WBGene00006682", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659" ] }, "reaction_10629479": { "compartment": "compartment_876", "id": "reaction_10629479", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629476", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629865": { "compartment": "compartment_876", "id": "reaction_10629865", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629862", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10629773": { "compartment": "compartment_876", "id": "reaction_10629773", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629770", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10629494": { "compartment": "compartment_876", "id": "reaction_10629494", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10629491", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629948": { "compartment": "compartment_876", "id": "reaction_10629948", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629945", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10660945": { "compartment": "compartment_70101", "id": "reaction_10660945", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941", "species_10615184" ], "products": [ "species_10660943" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660953": { "compartment": "compartment_70101", "id": "reaction_10660953", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941" ], "products": [ "species_10658641" ], "modifiers": [ [ "species_10615184", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "WBGene00005077" ] }, "reaction_10662401": { "compartment": "compartment_7660", "id": "reaction_10662401", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662397" ], "products": [ "species_10662399" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10658645": { "compartment": "compartment_7660", "id": "reaction_10658645", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658633", "species_10658641" ], "products": [ "species_10658643" ], "modifiers": [], "additional_components": [ "WBGene00000272", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662403": { "compartment": "compartment_70101", "id": "reaction_10662403", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662399" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660951": { "compartment": "compartment_70101", "id": "reaction_10660951", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10660943" ], "products": [ "species_29370", "species_10660948", "species_10615184" ], "modifiers": [ [ "species_10660943", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10615739": { "compartment": "compartment_876", "id": "reaction_10615739", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615735", "species_10615689" ], "products": [ "species_10615737" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10621789": { "compartment": "compartment_70101", "id": "reaction_10621789", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_113592", "species_10605399" ], "products": [ "species_29370", "species_10617723", "species_10621786" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "WBGene00003911" ] }, "reaction_10621774": { "compartment": "compartment_70101", "id": "reaction_10621774", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10618095": { "compartment": "compartment_70101", "id": "reaction_10618095", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612071", "species_113592", "species_10615689" ], "products": [ "species_10618093", "species_29370" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "Q5WRR1", "WBGene00006942", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10621778": { "compartment": "compartment_876", "id": "reaction_10621778", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10615689" ], "products": [ "species_10621776" ], "modifiers": [], "additional_components": [ "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P24348", "WBGene00002299" ] }, "reaction_10615733": { "compartment": "compartment_876", "id": "reaction_10615733", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615689" ], "products": [ "species_10615731" ], "modifiers": [], "additional_components": [ "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "C6KRM7", "WBGene00004372", "Q5WRR1", "WBGene00006942" ] }, "reaction_10614145": { "compartment": "compartment_70101", "id": "reaction_10614145", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614142", "species_29404" ], "products": [ "species_10614028" ], "modifiers": [ [ "species_10614142", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10614135": { "compartment": "compartment_984", "id": "reaction_10614135", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10614088" ], "products": [ "species_10614130", "species_10614132", "species_210382", "species_10614118", "species_10613945", "species_10614086", "species_10614100", "species_10614053" ], "modifiers": [ [ "species_10614088", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "species_74016", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10613856": { "compartment": "compartment_984", "id": "reaction_10613856", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_210382", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_29404", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ], [ "species_10613854", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624", "WBGene00017070" ] }, "reaction_10614091": { "compartment": "compartment_70101", "id": "reaction_10614091", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614028", "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048" ], "products": [ "species_10614088" ], "modifiers": [ [ "species_10614028", "catalyst" ], [ "species_10614068", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006752" ] }, "reaction_10636112": { "compartment": "compartment_5460", "id": "reaction_10636112", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10636120": { "compartment": "compartment_70616", "id": "reaction_10636120", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10636117", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10636123": { "compartment": "compartment_5460", "id": "reaction_10636123", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10614597": { "compartment": "compartment_70101", "id": "reaction_10614597", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_76194", "species_264643" ], "modifiers": [ [ "species_10614594", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10614589": { "compartment": "compartment_70101", "id": "reaction_10614589", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10614584" ], "products": [ "species_70106", "species_10614586" ], "modifiers": [ [ "species_10614568", "catalyst" ] ], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10615286": { "compartment": "compartment_70101", "id": "reaction_10615286", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614586", "species_10614053", "species_10614048" ], "products": [ "species_10615283" ], "modifiers": [ [ "species_10614586", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10615371": { "compartment": "compartment_876", "id": "reaction_10615371", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615283" ], "products": [ "species_10614130", "species_10614132", "species_10615368", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_372533" ], "modifiers": [ [ "species_10615283", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006756", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10645186": { "compartment": "compartment_261122", "id": "reaction_10645186", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645128" ], "products": [ "species_10645178" ], "modifiers": [ [ "species_10645184", "inhibitor" ] ], "additional_components": [ "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "Q21626", "WBGene00010974", "CHEBI:15996", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645954": { "compartment": "compartment_18730", "id": "reaction_10645954", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645950", "species_10645945" ], "products": [ "species_10645952" ], "modifiers": [], "additional_components": [ "WBGene00019536", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10645030": { "compartment": "compartment_13949", "id": "reaction_10645030", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645026", "species_10645008" ], "products": [ "species_10645028" ], "modifiers": [], "additional_components": [ "Q18286", "WBGene00016188", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "species_29438", "Q95ZS6", "WBGene00018869", "G5EFC1", "WBGene00004272", "O01803", "WBGene00004274", "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272" ] }, "reaction_10645054": { "compartment": "compartment_261122", "id": "reaction_10645054", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645028" ], "products": [ "species_10645052" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10645964": { "compartment": "compartment_18730", "id": "reaction_10645964", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645952" ], "modifiers": [ [ "species_10645950", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "WBGene00019536" ] }, "reaction_10645097": { "compartment": "compartment_70101", "id": "reaction_10645097", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644745", "species_10644720", "species_10644715", "species_10644735", "species_10644725", "species_10644710", "species_10644740", "species_10644730" ], "products": [ "species_10644747" ], "modifiers": [], "additional_components": [ "WBGene00019482", "WBGene00043992", "WBGene00000242", "WBGene00016744", "WBGene00010974", "WBGene00000241", "WBGene00000244", "WBGene00003892", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645130": { "compartment": "compartment_876", "id": "reaction_10645130", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10645126", "species_10645104" ], "products": [ "species_10645128" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q18510", "WBGene00000193", "species_29438", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086" ] }, "reaction_10645972": { "compartment": "compartment_18730", "id": "reaction_10645972", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645958" ], "products": [ "species_10645956", "species_10645950", "species_10645943" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "species_111349", "WBGene00019536", "WBGene00006843" ] }, "reaction_10645961": { "compartment": "compartment_18730", "id": "reaction_10645961", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645958" ], "modifiers": [ [ "species_10645952", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10644756": { "compartment": "compartment_2132649", "id": "reaction_10644756", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10644752" ], "products": [ "species_10644754" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "WBGene00010045", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q20759", "WBGene00010045", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10618833": { "compartment": "compartment_70101", "id": "reaction_10618833", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10618830", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "P91119", "WBGene00016328" ] }, "reaction_10631241": { "compartment": "compartment_70101", "id": "reaction_10631241", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612134", "species_1497857" ], "products": [ "species_29870", "species_10631239" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10630704": { "compartment": "compartment_70101", "id": "reaction_10630704", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630697", "species_10630689" ], "products": [ "species_10630699" ], "modifiers": [], "additional_components": [ "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10655778": { "compartment": "compartment_5460", "id": "reaction_10655778", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10655775", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10638217": { "compartment": "compartment_70101", "id": "reaction_10638217", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638215" ], "products": [ "species_111294", "species_76577", "species_10602923" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10610819": { "compartment": "compartment_70101", "id": "reaction_10610819", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10610816", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10638500": { "compartment": "compartment_70101", "id": "reaction_10638500", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638497", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10608120" ], "modifiers": [ [ "species_10638497", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10610781": { "compartment": "compartment_70101", "id": "reaction_10610781", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10611056": { "compartment": "compartment_876", "id": "reaction_10611056", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10611053", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207", "Q20734", "WBGene00043980" ] }, "reaction_10610836": { "compartment": "compartment_70101", "id": "reaction_10610836", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10630865": { "compartment": "compartment_70101", "id": "reaction_10630865", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630860", "species_113592" ], "products": [ "species_29370", "species_10630712" ], "modifiers": [ [ "species_10630862", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216667", "O02058", "WBGene00015010", "WBGene00015650" ] }, "reaction_10655786": { "compartment": "compartment_5460", "id": "reaction_10655786", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10655783", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10660041": { "compartment": "compartment_17927", "id": "reaction_10660041", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10660038", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10610809": { "compartment": "compartment_70101", "id": "reaction_10610809", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10610806", "catalyst" ] ], "additional_components": [ "P90755", "WBGene00007755" ] }, "reaction_10643425": { "compartment": "compartment_70101", "id": "reaction_10643425", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_71285", "species_549282" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10656369": { "compartment": "compartment_17951", "id": "reaction_10656369", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10656366", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10638520": { "compartment": "compartment_5460", "id": "reaction_10638520", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159297", "species_10599214" ], "products": [ "species_10599216" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10611068": { "compartment": "compartment_70101", "id": "reaction_10611068", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611065", "species_1497805" ], "products": [ "species_10611063", "species_198816" ], "modifiers": [ [ "species_10611065", "catalyst" ] ], "additional_components": [ "Q93315", "WBGene00007848", "species_71185", "Q93315", "WBGene00007848", "CHEBI:36144", "Q93315", "WBGene00007848", "species_71185" ] }, "reaction_10611568": { "compartment": "compartment_7660", "id": "reaction_10611568", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10611565", "catalyst" ] ], "additional_components": [ "species_216667", "P91851", "WBGene00009176" ] }, "reaction_10599221": { "compartment": "compartment_5460", "id": "reaction_10599221", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10599216", "catalyst" ] ], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10610789": { "compartment": "compartment_70101", "id": "reaction_10610789", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10638379": { "compartment": "compartment_70101", "id": "reaction_10638379", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3000241" ], "products": [ "species_29366", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10626242": { "compartment": "compartment_70101", "id": "reaction_10626242", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638503": { "compartment": "compartment_70101", "id": "reaction_10638503", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3149505" ], "products": [ "species_29366", "species_1130611", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10630701": { "compartment": "compartment_70101", "id": "reaction_10630701", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10630689", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_10630699", "inhibitor" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10638549": { "compartment": "compartment_70101", "id": "reaction_10638549", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10638546", "catalyst" ], [ "species_29386", "inhibitor" ], [ "species_73524", "inhibitor" ] ], "additional_components": [ "Q3LFN0", "WBGene00044637", "G4SDH4", "WBGene00021626" ] }, "reaction_10626228": { "compartment": "compartment_70101", "id": "reaction_10626228", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10611047": { "compartment": "compartment_70101", "id": "reaction_10611047", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "O45352", "WBGene00001792", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337" ] }, "reaction_10638491": { "compartment": "compartment_70101", "id": "reaction_10638491", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638483", "species_10638376" ], "products": [ "species_10638485" ], "modifiers": [], "additional_components": [ "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766" ] }, "reaction_10639602": { "compartment": "compartment_70101", "id": "reaction_10639602", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639600" ], "products": [ "species_10638369" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "species_266099", "O45430", "WBGene00009319" ] }, "reaction_10610846": { "compartment": "compartment_70101", "id": "reaction_10610846", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10610843", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10659491": { "compartment": "compartment_876", "id": "reaction_10659491", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10659488", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10611255": { "compartment": "compartment_876", "id": "reaction_10611255", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10611252", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10626163": { "compartment": "compartment_70101", "id": "reaction_10626163", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10626160", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10610799": { "compartment": "compartment_70101", "id": "reaction_10610799", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_29356" ], "products": [ "species_196931", "species_29372" ], "modifiers": [ [ "species_10610796", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10610771": { "compartment": "compartment_70101", "id": "reaction_10610771", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10610768", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_109496" ] }, "reaction_10662637": { "compartment": "compartment_5460", "id": "reaction_10662637", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113593" ], "products": [ "species_113563", "species_113581", "species_113529" ], "modifiers": [ [ "species_10662634", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10626240": { "compartment": "compartment_70101", "id": "reaction_10626240", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638489": { "compartment": "compartment_70101", "id": "reaction_10638489", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149479", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10626226": { "compartment": "compartment_70101", "id": "reaction_10626226", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10617657": { "compartment": "compartment_17951", "id": "reaction_10617657", "reactome": "R-CEL-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10617654", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10611561": { "compartment": "compartment_5460", "id": "reaction_10611561", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10611558", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10611139": { "compartment": "compartment_70101", "id": "reaction_10611139", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10611131" ], "products": [ "species_10602960", "species_158466" ], "modifiers": [ [ "species_10611136", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10630715": { "compartment": "compartment_70101", "id": "reaction_10630715", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10630712", "catalyst" ] ], "additional_components": [ "species_216667", "O02058", "WBGene00015010" ] }, "reaction_10638168": { "compartment": "compartment_70101", "id": "reaction_10638168", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638154" ], "products": [ "species_10638160", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10638207": { "compartment": "compartment_70101", "id": "reaction_10638207", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638200", "species_113592" ], "products": [ "species_10638205", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10626116": { "compartment": "compartment_70101", "id": "reaction_10626116", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10626113", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10638508": { "compartment": "compartment_70101", "id": "reaction_10638508", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149564", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10620516": { "compartment": "compartment_876", "id": "reaction_10620516", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_429739" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "species_8869604", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "species_197230", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "WBGene00014092" ] }, "reaction_10610761": { "compartment": "compartment_70101", "id": "reaction_10610761", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610758", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10638576": { "compartment": "compartment_70101", "id": "reaction_10638576", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10638573", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "O61198", "WBGene00017487", "O17892", "WBGene00010083", "Q960A1", "WBGene00015057", "CHEBI:44074", "species_113596" ] }, "reaction_10611119": { "compartment": "compartment_876", "id": "reaction_10611119", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_198836" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10611116", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "G8JZM6", "WBGene00021994", "O18057", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q9TYX7", "WBGene00021994", "Q18771", "WBGene00021994" ] }, "reaction_10641004": { "compartment": "compartment_70101", "id": "reaction_10641004", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10641002", "species_113592" ], "products": [ "species_111294", "species_10611528", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10626139": { "compartment": "compartment_70101", "id": "reaction_10626139", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10626123" ], "products": [ "species_10626128", "species_29432" ], "modifiers": [ [ "species_10626136", "catalyst" ] ], "additional_components": [ "species_216667", "O44510", "WBGene00018357", "species_216667", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10638578": { "compartment": "compartment_70101", "id": "reaction_10638578", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3149479", "species_10638495" ], "products": [ "species_10638497" ], "modifiers": [], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10626230": { "compartment": "compartment_70101", "id": "reaction_10626230", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10638518": { "compartment": "compartment_5460", "id": "reaction_10638518", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10638515", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10638506": { "compartment": "compartment_70101", "id": "reaction_10638506", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608124", "species_200665" ], "products": [ "species_10608120", "species_111355" ], "modifiers": [ [ "species_10608124", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260" ] }, "reaction_10626151": { "compartment": "compartment_70101", "id": "reaction_10626151", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10626148", "catalyst" ] ], "additional_components": [ "G5EGH2", "WBGene00003384", "species_109496" ] }, "reaction_10638382": { "compartment": "compartment_70101", "id": "reaction_10638382", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10638196": { "compartment": "compartment_70101", "id": "reaction_10638196", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638190", "species_113592" ], "products": [ "species_111294", "species_10638194", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10661102": { "compartment": "compartment_70101", "id": "reaction_10661102", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10644423": { "compartment": "compartment_70101", "id": "reaction_10644423", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644420", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "P90863", "WBGene00006682", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q21529", "WBGene00006658", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10660839": { "compartment": "compartment_7660", "id": "reaction_10660839", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660834", "species_77087" ], "products": [ "species_10660836", "species_77502" ], "modifiers": [ [ "species_10660834", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10661819": { "compartment": "compartment_7660", "id": "reaction_10661819", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10661812" ], "products": [ "species_10661816", "species_427486", "species_10661749" ], "modifiers": [ [ "species_10661812", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660958": { "compartment": "compartment_7660", "id": "reaction_10660958", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638691", "species_10658637" ], "products": [ "species_10660956" ], "modifiers": [], "additional_components": [ "Q09646", "WBGene00044072", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q09646", "WBGene00044072", "Q95ZL9", "WBGene00000272", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EFQ5", "WBGene00004393", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971" ] }, "reaction_10663484": { "compartment": "compartment_7660", "id": "reaction_10663484", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_29358" ], "products": [ "species_113582", "species_10663429" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10660771": { "compartment": "compartment_7660", "id": "reaction_10660771", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638603", "species_10658637" ], "products": [ "species_10660760" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661041": { "compartment": "compartment_7660", "id": "reaction_10661041", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661037", "species_10658637" ], "products": [ "species_10661039" ], "modifiers": [], "additional_components": [ "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660769": { "compartment": "compartment_7660", "id": "reaction_10660769", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660760", "species_77087" ], "products": [ "species_10660766", "species_77502" ], "modifiers": [ [ "species_10660760", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661097": { "compartment": "compartment_7660", "id": "reaction_10661097", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661087", "species_10597874" ], "products": [ "species_10661092", "species_10597899" ], "modifiers": [ [ "species_10661087", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "WBGene00004393", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10660861": { "compartment": "compartment_7660", "id": "reaction_10660861", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660856", "species_77087" ], "products": [ "species_10660858", "species_77502" ], "modifiers": [ [ "species_10660856", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10663499": { "compartment": "compartment_70101", "id": "reaction_10663499", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663486", "species_10627446" ], "products": [ "species_10663490" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660823": { "compartment": "compartment_7660", "id": "reaction_10660823", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660807", "species_77087" ], "products": [ "species_77502", "species_10660820" ], "modifiers": [ [ "species_10660807", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661089": { "compartment": "compartment_7660", "id": "reaction_10661089", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597899", "species_10660379" ], "products": [ "species_10661087" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00004393", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10661731": { "compartment": "compartment_7660", "id": "reaction_10661731", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658643", "species_10628901" ], "products": [ "species_10661729" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661099": { "compartment": "compartment_7660", "id": "reaction_10661099", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661092" ], "products": [ "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10664948": { "compartment": "compartment_7660", "id": "reaction_10664948", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611175", "species_10648260" ], "products": [ "species_10664946" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00006446", "O17850", "WBGene00006446", "O16850", "WBGene00000912" ] }, "reaction_10660832": { "compartment": "compartment_7660", "id": "reaction_10660832", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660827", "species_77087" ], "products": [ "species_10660829", "species_77502" ], "modifiers": [ [ "species_10660827", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10635481": { "compartment": "compartment_7660", "id": "reaction_10635481", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635477" ], "products": [ "species_10635479" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10663497": { "compartment": "compartment_70101", "id": "reaction_10663497", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10663490" ], "products": [ "species_10663492", "species_10627446" ], "modifiers": [ [ "species_10663490", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659819": { "compartment": "compartment_7660", "id": "reaction_10659819", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635483" ], "products": [ "species_10659817" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10635592": { "compartment": "compartment_7660", "id": "reaction_10635592", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635588", "species_10635496", "species_10635468" ], "products": [ "species_10635590" ], "modifiers": [], "additional_components": [ "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546", "WBGene00021636", "WBGene00008748", "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q9N3S7", "WBGene00021636", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q19404", "WBGene00008748", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546" ] }, "reaction_10660962": { "compartment": "compartment_7660", "id": "reaction_10660962", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10658637" ], "products": [ "species_10660960" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664997": { "compartment": "compartment_7660", "id": "reaction_10664997", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10611173" ], "products": [ "species_2485002", "species_10664992" ], "modifiers": [ [ "species_10664994", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366" ] }, "reaction_10664901": { "compartment": "compartment_70101", "id": "reaction_10664901", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664897", "species_10614198" ], "products": [ "species_10664899" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10660805": { "compartment": "compartment_7660", "id": "reaction_10660805", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660796", "species_77087" ], "products": [ "species_10660802", "species_77502" ], "modifiers": [ [ "species_10660796", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10660877": { "compartment": "compartment_7660", "id": "reaction_10660877", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660872", "species_77087" ], "products": [ "species_10660874", "species_77502" ], "modifiers": [ [ "species_10660872", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10635491": { "compartment": "compartment_7660", "id": "reaction_10635491", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635468", "species_10635477" ], "products": [ "species_10635489" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660884": { "compartment": "compartment_7660", "id": "reaction_10660884", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660879", "species_77087" ], "products": [ "species_10660881", "species_77502" ], "modifiers": [ [ "species_10660879", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10663445": { "compartment": "compartment_7660", "id": "reaction_10663445", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10663437" ], "products": [ "species_10660385", "species_113541" ], "modifiers": [ [ "species_10663442", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00021856" ] }, "reaction_10660389": { "compartment": "compartment_7660", "id": "reaction_10660389", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_10660383" ], "products": [ "species_10660387" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q95ZL9", "WBGene00000272", "P45896", "WBGene00004857", "G5EFQ5", "WBGene00004393", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10664907": { "compartment": "compartment_70101", "id": "reaction_10664907", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664903", "species_10664881" ], "products": [ "species_10664905" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10665000": { "compartment": "compartment_7660", "id": "reaction_10665000", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664992", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10611173" ], "modifiers": [ [ "species_10619855", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10664952": { "compartment": "compartment_7660", "id": "reaction_10664952", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10607873" ], "products": [ "species_10664950" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10660426": { "compartment": "compartment_7660", "id": "reaction_10660426", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10658637" ], "products": [ "species_113582", "species_10660419" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10661025": { "compartment": "compartment_7660", "id": "reaction_10661025", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661021", "species_10658637" ], "products": [ "species_10661023" ], "modifiers": [], "additional_components": [ "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664911": { "compartment": "compartment_70101", "id": "reaction_10664911", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664883", "species_10621567" ], "products": [ "species_10664909" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10659823": { "compartment": "compartment_7660", "id": "reaction_10659823", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635487", "species_10629366" ], "products": [ "species_10659821" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660224": { "compartment": "compartment_7660", "id": "reaction_10660224", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660220", "species_10658637" ], "products": [ "species_10660222" ], "modifiers": [], "additional_components": [ "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q86MF0", "WBGene00001439", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661755": { "compartment": "compartment_7660", "id": "reaction_10661755", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661739", "species_10661749" ], "products": [ "species_10661751" ], "modifiers": [ [ "species_10661753", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10662820": { "compartment": "compartment_7660", "id": "reaction_10662820", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10629366" ], "products": [ "species_113582", "species_10662817" ], "modifiers": [ [ "species_10648106", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10664885": { "compartment": "compartment_7660", "id": "reaction_10664885", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10660424": { "compartment": "compartment_7660", "id": "reaction_10660424", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660408", "species_29358" ], "products": [ "species_113582", "species_10660421" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10660428": { "compartment": "compartment_7660", "id": "reaction_10660428", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628901", "species_10658637" ], "products": [ "species_10660408" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659827": { "compartment": "compartment_7660", "id": "reaction_10659827", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635485", "species_10629366" ], "products": [ "species_10659825" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660868": { "compartment": "compartment_7660", "id": "reaction_10660868", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660863", "species_77087" ], "products": [ "species_10660865", "species_77502" ], "modifiers": [ [ "species_10660863", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661814": { "compartment": "compartment_7660", "id": "reaction_10661814", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661810", "species_10641328" ], "products": [ "species_10661812" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "WBGene00001837", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661742": { "compartment": "compartment_7660", "id": "reaction_10661742", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661729", "species_113560" ], "products": [ "species_2485002", "species_10661739" ], "modifiers": [ [ "species_10661729", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662813": { "compartment": "compartment_7660", "id": "reaction_10662813", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10658637" ], "products": [ "species_10662811" ], "modifiers": [ [ "species_10648106", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10657931": { "compartment": "compartment_7660", "id": "reaction_10657931", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657923", "species_10657927" ], "products": [ "species_10657929", "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00006380", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380", "Q10666", "WBGene00004077", "WBGene00001979" ] }, "reaction_10665048": { "compartment": "compartment_7660", "id": "reaction_10665048", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10628899" ], "products": [ "species_10665046" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000366", "P34545", "WBGene00000366", "O16850", "WBGene00000912" ] }, "reaction_10644162": { "compartment": "compartment_7660", "id": "reaction_10644162", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10643385", "species_10643390" ], "products": [ "species_10643405" ], "modifiers": [], "additional_components": [ "WBGene00003418", "WBGene00003422", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10644164": { "compartment": "compartment_7660", "id": "reaction_10644164", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643378", "species_10643373" ], "products": [ "species_10643380" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373" ] }, "reaction_10643409": { "compartment": "compartment_7660", "id": "reaction_10643409", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358514", "species_10643405" ], "products": [ "species_10643407" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643422": { "compartment": "compartment_7660", "id": "reaction_10643422", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10643407" ], "products": [ "species_113582", "species_10643394" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643398": { "compartment": "compartment_7660", "id": "reaction_10643398", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643380", "species_10598196", "species_10643394" ], "products": [ "species_10643396" ], "modifiers": [], "additional_components": [ "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "O02115", "WBGene00003955", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643420": { "compartment": "compartment_7660", "id": "reaction_10643420", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643416", "species_10643400" ], "products": [ "species_10643418" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O62245", "WBGene00009731", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643403": { "compartment": "compartment_7660", "id": "reaction_10643403", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643396" ], "products": [ "species_10643400" ], "modifiers": [ [ "species_10643396", "catalyst" ] ], "additional_components": [ "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10618428": { "compartment": "compartment_70101", "id": "reaction_10618428", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618374" ], "products": [ "species_29370", "species_10618425" ], "modifiers": [ [ "species_10618374", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111" ] }, "reaction_10618502": { "compartment": "compartment_70101", "id": "reaction_10618502", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618425", "species_113592" ], "products": [ "species_29370", "species_10618499" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10618464": { "compartment": "compartment_70101", "id": "reaction_10618464", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618238" ], "products": [ "species_29370", "species_10618461" ], "modifiers": [ [ "species_10613594", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q01630", "WBGene00006769", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q21773", "WBGene00000963", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "Q18677", "WBGene00000964", "Q22243", "WBGene00022780", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "O02064", "WBGene00022780" ] }, "reaction_10599289": { "compartment": "compartment_70101", "id": "reaction_10599289", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10599286", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10599309": { "compartment": "compartment_70101", "id": "reaction_10599309", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10599306", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10599299": { "compartment": "compartment_70101", "id": "reaction_10599299", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10599296", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10625266": { "compartment": "compartment_70101", "id": "reaction_10625266", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10639641": { "compartment": "compartment_70101", "id": "reaction_10639641", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10639638", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10639334": { "compartment": "compartment_5460", "id": "reaction_10639334", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10639331", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10639365": { "compartment": "compartment_984", "id": "reaction_10639365", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10639362", "catalyst" ] ], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10649479": { "compartment": "compartment_5460", "id": "reaction_10649479", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_113573", "species_5696194" ], "modifiers": [ [ "species_10649476", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10639564": { "compartment": "compartment_5460", "id": "reaction_10639564", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10639549" ], "products": [ "species_10639552", "species_113521" ], "modifiers": [ [ "species_10639561", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10639577": { "compartment": "compartment_5460", "id": "reaction_10639577", "reactome": "R-CEL-3323013", "name": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_1655887" ], "products": [ "species_1655882", "species_113521" ], "modifiers": [ [ "species_10639574", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10639589": { "compartment": "compartment_5460", "id": "reaction_10639589", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_10639552", "species_113529" ], "products": [ "species_113563", "species_10639549" ], "modifiers": [ [ "species_10639586", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10639598": { "compartment": "compartment_5460", "id": "reaction_10639598", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10639595", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10640254": { "compartment": "compartment_17927", "id": "reaction_10640254", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10640251", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639375": { "compartment": "compartment_70101", "id": "reaction_10639375", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10639372", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639607": { "compartment": "compartment_70616", "id": "reaction_10639607", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10606530" ], "products": [ "species_10606528", "species_189461" ], "modifiers": [], "additional_components": [ "Q23240", "WBGene00013854", "CHEBI:38574", "P19974", "WBGene00017121", "CHEBI:38573", "Q23240", "WBGene00013854", "P19974", "WBGene00017121" ] }, "reaction_10603119": { "compartment": "compartment_17951", "id": "reaction_10603119", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10603116", "catalyst" ] ], "additional_components": [ "species_71185", "Q8MYL7", "WBGene00013220", "species_113601" ] }, "reaction_10641727": { "compartment": "compartment_17963", "id": "reaction_10641727", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641725" ], "products": [ "species_10639362" ], "modifiers": [], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901", "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10599744": { "compartment": "compartment_70101", "id": "reaction_10599744", "reactome": "R-CEL-71676", "name": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10599741", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10649557": { "compartment": "compartment_7660", "id": "reaction_10649557", "reactome": "R-CEL-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10649551" ], "products": [ "species_10649553" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10649555": { "compartment": "compartment_7660", "id": "reaction_10649555", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10649553" ], "products": [ "species_427497", "species_10648323" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10648696": { "compartment": "compartment_7660", "id": "reaction_10648696", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641259", "species_10641290", "species_10648255" ], "products": [ "species_10648694" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "WBGene00022296", "WBGene00013924", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10649835": { "compartment": "compartment_7660", "id": "reaction_10649835", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648742", "species_10597874" ], "products": [ "species_10649551" ], "modifiers": [ [ "species_10648742", "catalyst" ] ], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648744": { "compartment": "compartment_7660", "id": "reaction_10648744", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10648740", "species_10648694" ], "products": [ "species_10648738", "species_10648742" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q23457", "WBGene00004320", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10633715": { "compartment": "compartment_12045", "id": "reaction_10633715", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10633712", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "Q21754", "WBGene00004039", "species_74016", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256" ] }, "reaction_10633605": { "compartment": "compartment_70101", "id": "reaction_10633605", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633602", "catalyst" ] ], "additional_components": [ "Q21754", "WBGene00004039", "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10633496": { "compartment": "compartment_70101", "id": "reaction_10633496", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10633493", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q95Q62", "WBGene00002979", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10633721": { "compartment": "compartment_70101", "id": "reaction_10633721", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633745": { "compartment": "compartment_876", "id": "reaction_10633745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633742", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q21754", "WBGene00004039", "species_74016", "G5EFI8", "WBGene00004036" ] }, "reaction_10633663": { "compartment": "compartment_70101", "id": "reaction_10633663", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10633660", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "species_109496" ] }, "reaction_10633682": { "compartment": "compartment_876", "id": "reaction_10633682", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633677", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10615561": { "compartment": "compartment_70101", "id": "reaction_10615561", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10615546" ], "products": [ "species_29370", "species_10615558" ], "modifiers": [ [ "species_10615546", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299" ] }, "reaction_10615698": { "compartment": "compartment_70101", "id": "reaction_10615698", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615694", "species_10615689" ], "products": [ "species_10615696" ], "modifiers": [], "additional_components": [ "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q9XWK4", "WBGene00013202" ] }, "reaction_10615677": { "compartment": "compartment_70101", "id": "reaction_10615677", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615453", "species_10615673" ], "products": [ "species_10615675" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00021369", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10658154": { "compartment": "compartment_70101", "id": "reaction_10658154", "reactome": "R-CEL-8855237", "name": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658145" ], "products": [ "species_29370", "species_10658152" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "WBGene00005077" ] }, "reaction_10618622": { "compartment": "compartment_70101", "id": "reaction_10618622", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618613", "species_10618615" ], "products": [ "species_10618617" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10615963": { "compartment": "compartment_984", "id": "reaction_10615963", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615959" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "WBGene00004372", "P17139", "WBGene00001263", "C6KRM7", "WBGene00004372", "P17139", "WBGene00001263" ] }, "reaction_10618620": { "compartment": "compartment_70101", "id": "reaction_10618620", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10618617", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10663513": { "compartment": "compartment_984", "id": "reaction_10663513", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_2299699" ], "products": [ "species_10663511" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10618951": { "compartment": "compartment_70101", "id": "reaction_10618951", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615741", "species_10615184" ], "products": [ "species_10615743" ], "modifiers": [], "additional_components": [ "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00005077", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615457": { "compartment": "compartment_876", "id": "reaction_10615457", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615453" ], "products": [ "species_10615455" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618943": { "compartment": "compartment_70101", "id": "reaction_10618943", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618938", "species_10617638" ], "products": [ "species_10618940", "species_29420" ], "modifiers": [ [ "species_10618938", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615459": { "compartment": "compartment_984", "id": "reaction_10615459", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615451", "species_10615440" ], "products": [ "species_10615453" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10624235": { "compartment": "compartment_876", "id": "reaction_10624235", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231", "species_10624224" ], "products": [ "species_10624233" ], "modifiers": [], "additional_components": [ "Q26261", "WBGene00006745", "G5EF96", "unc-40", "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "unc-40", "O44565", "WBGene00002247" ] }, "reaction_10618294": { "compartment": "compartment_70101", "id": "reaction_10618294", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618273", "species_10618290" ], "products": [ "species_10618292", "species_10615191" ], "modifiers": [], "additional_components": [ "WBGene00001490", "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10618595": { "compartment": "compartment_70101", "id": "reaction_10618595", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618584" ], "products": [ "species_29372", "species_10618586" ], "modifiers": [ [ "species_10618592", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "G5EBK8", "WBGene00004310", "species_111349", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10616046": { "compartment": "compartment_70101", "id": "reaction_10616046", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616020", "species_10616042" ], "products": [ "species_10616044" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618605": { "compartment": "compartment_70101", "id": "reaction_10618605", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10618602", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10618949": { "compartment": "compartment_70101", "id": "reaction_10618949", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618936", "species_10615485" ], "products": [ "species_10618938" ], "modifiers": [], "additional_components": [ "WBGene00000419", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618564": { "compartment": "compartment_70101", "id": "reaction_10618564", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618560", "species_10605399" ], "products": [ "species_10618562" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "Q03206", "ced-10", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q03206", "ced-10", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "species_29438", "Q95XP4", "WBGene00003111" ] }, "reaction_10618025": { "compartment": "compartment_70101", "id": "reaction_10618025", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10618020", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10615659": { "compartment": "compartment_876", "id": "reaction_10615659", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615655" ], "products": [ "species_10615657" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "unc-40", "species_179856" ] }, "reaction_10616034": { "compartment": "compartment_876", "id": "reaction_10616034", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616030" ], "products": [ "species_10616032" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10615967": { "compartment": "compartment_984", "id": "reaction_10615967", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_114570" ], "products": [ "species_10615965" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_113592" ] }, "reaction_10618022": { "compartment": "compartment_70101", "id": "reaction_10618022", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10618014" ], "products": [ "species_10618020" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618016": { "compartment": "compartment_70101", "id": "reaction_10618016", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602400", "species_10618010" ], "products": [ "species_10618014" ], "modifiers": [], "additional_components": [ "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618955": { "compartment": "compartment_70101", "id": "reaction_10618955", "reactome": "R-CEL-418874", "name": "Recruitment and activation of N-WASP by Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618940", "species_10612328", "species_179856" ], "products": [ "species_10618953" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "WBGene00007840", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_179856", "O62422", "WBGene00012532" ] }, "reaction_10663935": { "compartment": "compartment_984", "id": "reaction_10663935", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_2299699" ], "products": [ "species_10663933" ], "modifiers": [], "additional_components": [ "species_2299699", "G5EF96", "unc-40" ] }, "reaction_10615746": { "compartment": "compartment_70101", "id": "reaction_10615746", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615743", "species_113592" ], "products": [ "species_29370", "species_10615483" ], "modifiers": [ [ "species_10615743", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615650": { "compartment": "compartment_70101", "id": "reaction_10615650", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615646", "species_179856" ], "products": [ "species_10615648" ], "modifiers": [], "additional_components": [ "WBGene00001333", "G5EBK3", "WBGene00001333", "species_179856" ] }, "reaction_10618996": { "compartment": "compartment_70101", "id": "reaction_10618996", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10618993" ], "products": [ "species_29370", "species_10618560" ], "modifiers": [ [ "species_10618993", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10618318": { "compartment": "compartment_70101", "id": "reaction_10618318", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618242", "species_113592" ], "products": [ "species_29370", "species_10618315" ], "modifiers": [ [ "species_10618242", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780" ] }, "reaction_10660741": { "compartment": "compartment_70101", "id": "reaction_10660741", "reactome": "R-CEL-8933328", "name": "LYPLA2 hydrolyses PALM-C3,4-GAP43", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660731", "species_29356" ], "products": [ "species_3632881", "species_10660733" ], "modifiers": [ [ "species_10660738", "catalyst" ] ], "additional_components": [ "WBGene00018214", "WBGene00018214", "WBGene00010564" ] }, "reaction_10622809": { "compartment": "compartment_70101", "id": "reaction_10622809", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622806" ], "products": [ "species_29370", "species_10609588" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618607": { "compartment": "compartment_70101", "id": "reaction_10618607", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618600", "species_10618592" ], "products": [ "species_10618602" ], "modifiers": [], "additional_components": [ "WBGene00010374", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10615487": { "compartment": "compartment_70101", "id": "reaction_10615487", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615471", "species_10615483" ], "products": [ "species_10615485" ], "modifiers": [], "additional_components": [ "WBGene00006410", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615671": { "compartment": "compartment_70101", "id": "reaction_10615671", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615667", "species_10615453" ], "products": [ "species_10615669" ], "modifiers": [], "additional_components": [ "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618283": { "compartment": "compartment_876", "id": "reaction_10618283", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618208", "species_10618277" ], "products": [ "species_10618273", "species_10618281" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "O17905", "WBGene00001490", "WBGene00001490", "G5EE56", "WBGene00005077", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615500": { "compartment": "compartment_876", "id": "reaction_10615500", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615494", "species_10615496" ], "products": [ "species_10615498" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10615662": { "compartment": "compartment_70101", "id": "reaction_10615662", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615648" ], "products": [ "species_29370", "species_10615655" ], "modifiers": [ [ "species_10612166", "catalyst" ] ], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "WBGene00006599" ] }, "reaction_10622784": { "compartment": "compartment_70101", "id": "reaction_10622784", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618244": { "compartment": "compartment_70101", "id": "reaction_10618244", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618240", "species_10617742" ], "products": [ "species_10618242", "species_10617744" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10612171": { "compartment": "compartment_876", "id": "reaction_10612171", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10612168" ], "modifiers": [ [ "species_10612152", "catalyst" ] ], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10603943": { "compartment": "compartment_5460", "id": "reaction_10603943", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77276" ], "products": [ "species_77269", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603937": { "compartment": "compartment_5460", "id": "reaction_10603937", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603940": { "compartment": "compartment_5460", "id": "reaction_10603940", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10606622": { "compartment": "compartment_70101", "id": "reaction_10606622", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606632": { "compartment": "compartment_70101", "id": "reaction_10606632", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29878", "species_29790" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606636": { "compartment": "compartment_70101", "id": "reaction_10606636", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10610356": { "compartment": "compartment_984", "id": "reaction_10610356", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10610351": { "compartment": "compartment_984", "id": "reaction_10610351", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_174602", "species_171149" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10662935": { "compartment": "compartment_984", "id": "reaction_10662935", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10662932", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10610354": { "compartment": "compartment_984", "id": "reaction_10610354", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_192438", "species_174602" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10646460": { "compartment": "compartment_70101", "id": "reaction_10646460", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661262" ], "modifiers": [ [ "species_10646457", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10646450": { "compartment": "compartment_70101", "id": "reaction_10646450", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_29366", "species_5660033" ], "modifiers": [ [ "species_10646447", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10646471": { "compartment": "compartment_70101", "id": "reaction_10646471", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661281" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10646468": { "compartment": "compartment_70101", "id": "reaction_10646468", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661281", "species_113592" ], "products": [ "species_29370", "species_29790" ], "modifiers": [ [ "species_10646465", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10637289": { "compartment": "compartment_984", "id": "reaction_10637289", "reactome": "R-CEL-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_351629" ], "products": [ "species_10637270" ], "modifiers": [ [ "species_10637286", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:15858", "Q20616", "WBGene00009897" ] }, "reaction_10630811": { "compartment": "compartment_984", "id": "reaction_10630811", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630807" ], "products": [ "species_10630809" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636388": { "compartment": "compartment_984", "id": "reaction_10636388", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630809" ], "products": [ "species_10636386" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636390": { "compartment": "compartment_984", "id": "reaction_10636390", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631426" ], "products": [ "species_10631430" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263" ] }, "reaction_10648222": { "compartment": "compartment_5460", "id": "reaction_10648222", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598736", "species_113526" ], "products": [ "species_10648212", "species_5688274" ], "modifiers": [ [ "species_10648219", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "species_216667", "Q20480", "WBGene00004801" ] }, "reaction_10601562": { "compartment": "compartment_70101", "id": "reaction_10601562", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "products": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10601250": { "compartment": "compartment_70101", "id": "reaction_10601250", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601239" ], "products": [ "species_29370", "species_29372", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10666329": { "compartment": "compartment_12045", "id": "reaction_10666329", "reactome": "R-CEL-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666306": { "compartment": "compartment_70101", "id": "reaction_10666306", "reactome": "R-CEL-9751201", "name": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_9748947" ], "products": [ "species_10635280", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10666331": { "compartment": "compartment_70101", "id": "reaction_10666331", "reactome": "R-CEL-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10666335": { "compartment": "compartment_70101", "id": "reaction_10666335", "reactome": "R-CEL-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10666327": { "compartment": "compartment_70101", "id": "reaction_10666327", "reactome": "R-CEL-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10666324", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q9U2G5", "WBGene00003413", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411" ] }, "reaction_10636049": { "compartment": "compartment_70101", "id": "reaction_10636049", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10636046", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666268": { "compartment": "compartment_984", "id": "reaction_10666268", "reactome": "R-CEL-9749583", "name": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749786" ], "products": [ "species_9749576" ], "modifiers": [ [ "species_10624115", "catalyst" ] ], "additional_components": [ "species_9749790", "species_9749785", "species_9749790", "species_9749785", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666317": { "compartment": "compartment_70101", "id": "reaction_10666317", "reactome": "R-CEL-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10608242", "catalyst" ] ], "additional_components": [ "P10299", "WBGene00001749" ] }, "reaction_10666295": { "compartment": "compartment_70101", "id": "reaction_10666295", "reactome": "R-CEL-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003411" ] }, "reaction_10666333": { "compartment": "compartment_876", "id": "reaction_10666333", "reactome": "R-CEL-9753634", "name": "GGT dimers hydrolyse APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753685", "species_29356" ], "products": [ "species_9753680", "species_29404" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10666285": { "compartment": "compartment_17957", "id": "reaction_10666285", "reactome": "R-CEL-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666314": { "compartment": "compartment_70101", "id": "reaction_10666314", "reactome": "R-CEL-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10666252": { "compartment": "compartment_70101", "id": "reaction_10666252", "reactome": "R-CEL-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10636101": { "compartment": "compartment_70101", "id": "reaction_10636101", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10636104": { "compartment": "compartment_70101", "id": "reaction_10636104", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10599778", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10606291": { "compartment": "compartment_70101", "id": "reaction_10606291", "reactome": "R-CEL-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10606288", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10666322": { "compartment": "compartment_70101", "id": "reaction_10666322", "reactome": "R-CEL-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10666319", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412" ] }, "reaction_10666236": { "compartment": "compartment_70101", "id": "reaction_10666236", "reactome": "R-CEL-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10601884", "catalyst" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682" ] }, "reaction_10666250": { "compartment": "compartment_70101", "id": "reaction_10666250", "reactome": "R-CEL-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666257": { "compartment": "compartment_70101", "id": "reaction_10666257", "reactome": "R-CEL-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666289": { "compartment": "compartment_17957", "id": "reaction_10666289", "reactome": "R-CEL-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666302": { "compartment": "compartment_70101", "id": "reaction_10666302", "reactome": "R-CEL-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "WBGene00009499" ] }, "reaction_10666240": { "compartment": "compartment_70101", "id": "reaction_10666240", "reactome": "R-CEL-9748951", "name": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_9748998" ], "products": [ "species_9748992", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10666281": { "compartment": "compartment_17957", "id": "reaction_10666281", "reactome": "R-CEL-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10648942", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666304": { "compartment": "compartment_70101", "id": "reaction_10666304", "reactome": "R-CEL-9751037", "name": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015", "species_74113" ], "products": [ "species_83910", "species_9748998" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "WBGene00017867" ] }, "reaction_10666292": { "compartment": "compartment_70101", "id": "reaction_10666292", "reactome": "R-CEL-9750546", "name": "ABCC4 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750587", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750548", "species_29372" ], "modifiers": [ [ "species_10630658", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "pubchem.compound:3037883", "CHEBI:80613", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003412" ] }, "reaction_10666287": { "compartment": "compartment_5460", "id": "reaction_10666287", "reactome": "R-CEL-9750001", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749985", "species_159549" ], "products": [ "species_29374", "species_9750005" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10666245": { "compartment": "compartment_70101", "id": "reaction_10666245", "reactome": "R-CEL-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10666242", "catalyst" ] ], "additional_components": [ "Q09580", "WBGene00010912" ] }, "reaction_10666247": { "compartment": "compartment_70101", "id": "reaction_10666247", "reactome": "R-CEL-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10666255": { "compartment": "compartment_70101", "id": "reaction_10666255", "reactome": "R-CEL-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10608198", "catalyst" ] ], "additional_components": [ "O45010", "WBGene00021127" ] }, "reaction_10666278": { "compartment": "compartment_984", "id": "reaction_10666278", "reactome": "R-CEL-9749609", "name": "BCHE hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9749598" ], "products": [ "species_1524044", "species_351626", "species_9749546" ], "modifiers": [ [ "species_10666275", "catalyst" ] ], "additional_components": [ "WBGene00000037" ] }, "reaction_10666273": { "compartment": "compartment_984", "id": "reaction_10666273", "reactome": "R-CEL-9749607", "name": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749598" ], "products": [ "species_9749785" ], "modifiers": [ [ "species_10666270", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10666311": { "compartment": "compartment_70101", "id": "reaction_10666311", "reactome": "R-CEL-9753277", "name": "SULT dimers sulfate APAP to APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_9677362" ], "products": [ "species_9753448", "species_158466" ], "modifiers": [ [ "species_10666308", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10666283": { "compartment": "compartment_17957", "id": "reaction_10666283", "reactome": "R-CEL-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666300": { "compartment": "compartment_70101", "id": "reaction_10666300", "reactome": "R-CEL-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10666297", "catalyst" ] ], "additional_components": [ "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10636044": { "compartment": "compartment_70101", "id": "reaction_10636044", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161194", "species_29356" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10666238": { "compartment": "compartment_70101", "id": "reaction_10666238", "reactome": "R-CEL-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10661697": { "compartment": "compartment_70101", "id": "reaction_10661697", "reactome": "R-CEL-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648618", "species_10661684" ], "products": [ "species_10661694", "species_111294", "species_76577" ], "modifiers": [ [ "species_10661684", "catalyst" ] ], "additional_components": [ "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341" ] }, "reaction_10601554": { "compartment": "compartment_70101", "id": "reaction_10601554", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601535", "species_10601180" ], "products": [ "species_10601180", "species_10601108", "species_10601533" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00019162", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438" ] }, "reaction_10626992": { "compartment": "compartment_20699", "id": "reaction_10626992", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10626989", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10661677": { "compartment": "compartment_70101", "id": "reaction_10661677", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648620" ], "products": [ "species_10648618", "species_10648609" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657880": { "compartment": "compartment_70101", "id": "reaction_10657880", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10657877", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10606457": { "compartment": "compartment_17957", "id": "reaction_10606457", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10606454", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10662783": { "compartment": "compartment_70101", "id": "reaction_10662783", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10662772" ], "products": [ "species_10628859", "species_10662776" ], "modifiers": [ [ "species_10662772", "catalyst" ], [ "species_10662781", "inhibitor" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601258": { "compartment": "compartment_70101", "id": "reaction_10601258", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601197" ], "products": [ "species_10601199" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10627051": { "compartment": "compartment_20699", "id": "reaction_10627051", "reactome": "R-CEL-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10627048", "catalyst" ] ], "additional_components": [ "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10659540": { "compartment": "compartment_70101", "id": "reaction_10659540", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655541", "species_1131164", "species_10659531" ], "products": [ "species_10659538" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10622073": { "compartment": "compartment_17957", "id": "reaction_10622073", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10622070", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10606473": { "compartment": "compartment_12045", "id": "reaction_10606473", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10606470", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10622158": { "compartment": "compartment_17957", "id": "reaction_10622158", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10662739": { "compartment": "compartment_70101", "id": "reaction_10662739", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662726" ], "products": [ "species_10648618", "species_10662736" ], "modifiers": [ [ "species_10658432", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q93725", "WBGene00003587", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "A0A0K3AQR5", "T28F2.2b", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00003587", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A0A0K3AQR5", "T28F2.2b", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622134": { "compartment": "compartment_12045", "id": "reaction_10622134", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449222", "species_162756" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10622131", "catalyst" ] ], "additional_components": [ "U4PE03", "WBGene00019725", "P92012", "WBGene00011193" ] }, "reaction_10665016": { "compartment": "compartment_12045", "id": "reaction_10665016", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665014" ], "products": [ "species_10647827" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10622160": { "compartment": "compartment_17957", "id": "reaction_10622160", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10657617": { "compartment": "compartment_70101", "id": "reaction_10657617", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10657614", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P90859", "WBGene00009164", "Q9TW67", "WBGene00010160", "O16368", "WBGene00004502", "P54812", "WBGene00008053", "Q23451", "WBGene00013924", "Q9TXH9", "WBGene00017733", "Q93561", "WBGene00000843" ] }, "reaction_10659527": { "compartment": "compartment_70101", "id": "reaction_10659527", "reactome": "R-CEL-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659521" ], "products": [ "species_10659525" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00004184", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10622089": { "compartment": "compartment_17957", "id": "reaction_10622089", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10622086", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10647344": { "compartment": "compartment_70101", "id": "reaction_10647344", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10601707" ], "products": [ "species_174390", "species_10601705" ], "modifiers": [ [ "species_10647341", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "P34436", "WBGene00018419" ] }, "reaction_10622168": { "compartment": "compartment_12045", "id": "reaction_10622168", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10622165", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10647352": { "compartment": "compartment_70101", "id": "reaction_10647352", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10647349", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10654760": { "compartment": "compartment_70101", "id": "reaction_10654760", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654738", "species_71284" ], "products": [ "species_10654745", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10647679": { "compartment": "compartment_7660", "id": "reaction_10647679", "reactome": "R-CEL-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647675", "species_10647670" ], "products": [ "species_10647677" ], "modifiers": [], "additional_components": [ "WBGene00015217", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q17525", "WBGene00015217" ] }, "reaction_10626198": { "compartment": "compartment_20699", "id": "reaction_10626198", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10626195", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10648804": { "compartment": "compartment_70101", "id": "reaction_10648804", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10648801", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10606465": { "compartment": "compartment_12045", "id": "reaction_10606465", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10606462", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10601558": { "compartment": "compartment_70101", "id": "reaction_10601558", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601175", "species_10601180", "species_10601108" ], "products": [ "species_10601556" ], "modifiers": [], "additional_components": [ "O61820", "WBGene00001228", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "P30642", "WBGene00001227", "Q94261", "WBGene00019543", "Q9XUP3", "WBGene00001233", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "Q18967", "WBGene00001229", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10601550": { "compartment": "compartment_70101", "id": "reaction_10601550", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601544" ], "products": [ "species_10601548", "species_10601546", "species_29372" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "species_29420", "G5EGT7", "WBGene00021857" ] }, "reaction_10606481": { "compartment": "compartment_70101", "id": "reaction_10606481", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10606478", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10614701": { "compartment": "compartment_876", "id": "reaction_10614701", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614687", "species_10614677", "species_10614697", "species_10614672", "species_10614692", "species_10614682", "species_10614667", "species_10614662" ], "products": [ "species_10614699" ], "modifiers": [], "additional_components": [ "WBGene00018703", "WBGene00016188", "WBGene00016606", "WBGene00016376", "WBGene00017284", "WBGene00013687", "WBGene00004752", "WBGene00004753", "Q18286", "WBGene00016188", "Q19262", "WBGene00017284", "Q18406", "WBGene00016376", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753" ] }, "reaction_10658789": { "compartment": "compartment_70101", "id": "reaction_10658789", "reactome": "R-CEL-8865774", "name": "TTLLs polyglutamylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29404" ], "products": [ "species_29370", "species_10658759", "species_29372" ], "modifiers": [ [ "species_10658786", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q564U4", "WBGene00044187", "H2KZM9", "WBGene00019230", "Q09512", "WBGene00008405", "Q09647", "WBGene00014232", "E9P886", "WBGene00008331" ] }, "reaction_10620021": { "compartment": "compartment_876", "id": "reaction_10620021", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620018", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10622109": { "compartment": "compartment_17957", "id": "reaction_10622109", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10622106", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10659795": { "compartment": "compartment_70101", "id": "reaction_10659795", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659631", "species_1131164" ], "products": [ "species_10659790", "species_111294", "species_10659792" ], "modifiers": [ [ "species_10659631", "catalyst" ] ], "additional_components": [ "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662768": { "compartment": "compartment_7660", "id": "reaction_10662768", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662761" ], "products": [ "species_10662763", "species_10662765" ], "modifiers": [ [ "species_10648738", "catalyst" ] ], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q93725", "WBGene00003587", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00003587", "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622081": { "compartment": "compartment_12045", "id": "reaction_10622081", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10622078", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10647620": { "compartment": "compartment_2133233", "id": "reaction_10647620", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10647617", "catalyst" ] ], "additional_components": [ "species_1602402", "species_194276", "species_1602402", "species_194276", "WBGene00000020" ] }, "reaction_10650582": { "compartment": "compartment_3828046", "id": "reaction_10650582", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647837" ], "products": [ "species_10647960" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10628543": { "compartment": "compartment_70101", "id": "reaction_10628543", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628539" ], "products": [ "species_10628541" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727" ] }, "reaction_10662774": { "compartment": "compartment_70101", "id": "reaction_10662774", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662770", "species_10628807" ], "products": [ "species_10662772" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "WBGene00001851", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601260": { "compartment": "compartment_70101", "id": "reaction_10601260", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601199", "species_72393" ], "products": [ "species_10601201" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10633480": { "compartment": "compartment_70101", "id": "reaction_10633480", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633474", "species_10633476" ], "products": [ "species_10633478" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91240", "WBGene00017245", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "O16927", "WBGene00017799", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O61749", "WBGene00018159", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P34642", "WBGene00013984", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "G5EE80", "WBGene00009012", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P91240", "WBGene00017245", "P90983", "WBGene00004498", "Q20822", "WBGene00010097", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10601560": { "compartment": "compartment_70101", "id": "reaction_10601560", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601556", "species_10601201" ], "products": [ "species_10601203" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "species_29438", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "Q95XR0", "WBGene00021466", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10622142": { "compartment": "compartment_12045", "id": "reaction_10622142", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10622139", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10601252": { "compartment": "compartment_70101", "id": "reaction_10601252", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601231", "species_10601226", "species_10601221" ], "products": [ "species_10601233" ], "modifiers": [], "additional_components": [ "WBGene00002066", "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10659633": { "compartment": "compartment_70101", "id": "reaction_10659633", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659538", "species_10659629" ], "products": [ "species_10659631" ], "modifiers": [], "additional_components": [ "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662660": { "compartment": "compartment_7660", "id": "reaction_10662660", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662451", "species_10662656" ], "products": [ "species_10662658" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00013606", "Q18963", "WBGene00008403", "G5ED41", "WBGene00013606", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320" ] }, "reaction_10606489": { "compartment": "compartment_12045", "id": "reaction_10606489", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10606486", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10661701": { "compartment": "compartment_70101", "id": "reaction_10661701", "reactome": "R-CEL-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661694", "species_113592", "species_10648618" ], "products": [ "species_10661699", "species_111294", "species_76577" ], "modifiers": [], "additional_components": [ "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587" ] }, "reaction_10622064": { "compartment": "compartment_17957", "id": "reaction_10622064", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10622056", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10647958": { "compartment": "compartment_3828046", "id": "reaction_10647958", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647827", "species_5685882" ], "products": [ "species_10647847", "species_10647837", "species_10647857" ], "modifiers": [ [ "species_10647955", "catalyst" ] ], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "Q9BL26", "WBGene00044760", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O01532", "WBGene00000218", "Q8MYN7", "WBGene00012681", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q22972", "WBGene00017881", "O01530", "WBGene00000219", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "U4PME4", "WBGene00044760" ] }, "reaction_10605938": { "compartment": "compartment_70101", "id": "reaction_10605938", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605934" ], "products": [ "species_10605936" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10662654": { "compartment": "compartment_70101", "id": "reaction_10662654", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662650", "species_10648772" ], "products": [ "species_10662652" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00013606", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "G5ED41", "WBGene00013606", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10601552": { "compartment": "compartment_70101", "id": "reaction_10601552", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601246", "species_10601542", "species_10601533" ], "products": [ "species_10601544" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "G5EGT7", "WBGene00021857", "species_29438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625280": { "compartment": "compartment_17957", "id": "reaction_10625280", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623945", "species_10625276" ], "products": [ "species_10625278" ], "modifiers": [], "additional_components": [ "WBGene00003964", "P34652", "WBGene00000567", "CHEBI:59080", "P27798", "WBGene00000802", "P34652", "WBGene00000567", "CHEBI:59080", "G5ED07", "WBGene00003964", "P27798", "WBGene00000802" ] }, "reaction_10659533": { "compartment": "compartment_70101", "id": "reaction_10659533", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659529" ], "products": [ "species_10659531" ], "modifiers": [ [ "species_10659525", "inhibitor" ] ], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10630959": { "compartment": "compartment_12045", "id": "reaction_10630959", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10661834": { "compartment": "compartment_984", "id": "reaction_10661834", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10661831", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10660478": { "compartment": "compartment_5460", "id": "reaction_10660478", "reactome": "R-CEL-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10660475", "catalyst" ] ], "additional_components": [ "WBGene00008801" ] }, "reaction_10631941": { "compartment": "compartment_984", "id": "reaction_10631941", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_109276" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631070": { "compartment": "compartment_12045", "id": "reaction_10631070", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10631067", "catalyst" ] ], "additional_components": [ "Q9U2G1", "WBGene00012897", "species_266099", "species_109496" ] }, "reaction_10631934": { "compartment": "compartment_984", "id": "reaction_10631934", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602375" ], "products": [ "species_1602366", "species_1602372" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631217": { "compartment": "compartment_20699", "id": "reaction_10631217", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631155" ], "products": [ "species_10631215" ], "modifiers": [], "additional_components": [ "Q965T2", "WBGene00021854", "species_194276", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631939": { "compartment": "compartment_984", "id": "reaction_10631939", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631075": { "compartment": "compartment_70101", "id": "reaction_10631075", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970", "species_1500578" ], "products": [ "species_76194", "species_75973" ], "modifiers": [ [ "species_10631072", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10630911": { "compartment": "compartment_17906", "id": "reaction_10630911", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10630908", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10630922": { "compartment": "compartment_12045", "id": "reaction_10630922", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10623952": { "compartment": "compartment_12045", "id": "reaction_10623952", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10603021", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q9N5S8", "WBGene00018657", "Q21812", "WBGene00011106" ] }, "reaction_10631123": { "compartment": "compartment_70616", "id": "reaction_10631123", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524067", "species_1524072" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10603078": { "compartment": "compartment_70101", "id": "reaction_10603078", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_75970" ], "products": [ "species_29360", "species_76114" ], "modifiers": [ [ "species_10603075", "catalyst" ] ], "additional_components": [ "P34517", "WBGene00010778", "Q9XTS4", "WBGene00009824" ] }, "reaction_10660215": { "compartment": "compartment_12045", "id": "reaction_10660215", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10660211" ], "products": [ "species_10660213" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10631235": { "compartment": "compartment_12045", "id": "reaction_10631235", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631219" ], "products": [ "species_10631153" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "species_426639", "Q965T2", "WBGene00021854" ] }, "reaction_10630997": { "compartment": "compartment_12045", "id": "reaction_10630997", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630967": { "compartment": "compartment_17906", "id": "reaction_10630967", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10630944": { "compartment": "compartment_12045", "id": "reaction_10630944", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631007": { "compartment": "compartment_12045", "id": "reaction_10631007", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10630887": { "compartment": "compartment_12045", "id": "reaction_10630887", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10630919": { "compartment": "compartment_12045", "id": "reaction_10630919", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10649397": { "compartment": "compartment_70101", "id": "reaction_10649397", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10649394", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10631146": { "compartment": "compartment_12045", "id": "reaction_10631146", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10631143", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10649433": { "compartment": "compartment_17906", "id": "reaction_10649433", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10649430", "catalyst" ] ], "additional_components": [ "species_114519", "species_6814795", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_109496" ] }, "reaction_10631014": { "compartment": "compartment_12045", "id": "reaction_10631014", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10659846": { "compartment": "compartment_70101", "id": "reaction_10659846", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659841", "species_113592" ], "products": [ "species_29370", "species_10659844" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10631167": { "compartment": "compartment_12045", "id": "reaction_10631167", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10631164", "catalyst" ] ], "additional_components": [ "P53439", "WBGene00016384", "species_109496" ] }, "reaction_10609637": { "compartment": "compartment_5460", "id": "reaction_10609637", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10609634", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10649368": { "compartment": "compartment_876", "id": "reaction_10649368", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10649365", "catalyst" ] ], "additional_components": [ "Q9U1Z6", "WBGene00013358", "Q18610", "WBGene00016644" ] }, "reaction_10631157": { "compartment": "compartment_20699", "id": "reaction_10631157", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631153", "species_429785" ], "products": [ "species_1524146", "species_10631155" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631041": { "compartment": "compartment_12045", "id": "reaction_10631041", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10631038", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631060": { "compartment": "compartment_20699", "id": "reaction_10631060", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10631057", "catalyst" ] ], "additional_components": [ "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631190": { "compartment": "compartment_12045", "id": "reaction_10631190", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10631187", "catalyst" ] ], "additional_components": [ "WBGene00012095" ] }, "reaction_10631120": { "compartment": "compartment_70101", "id": "reaction_10631120", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10631117", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631016": { "compartment": "compartment_12045", "id": "reaction_10631016", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630906": { "compartment": "compartment_12045", "id": "reaction_10630906", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631182": { "compartment": "compartment_12045", "id": "reaction_10631182", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10631177", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10631937": { "compartment": "compartment_984", "id": "reaction_10631937", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10603033": { "compartment": "compartment_12045", "id": "reaction_10603033", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10603030", "catalyst" ] ], "additional_components": [ "Q95R12", "WBGene00017888", "G5EE59", "WBGene00010902", "Q22267", "WBGene00011543", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q21812", "WBGene00011106" ] }, "reaction_10631932": { "compartment": "compartment_984", "id": "reaction_10631932", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426658", "species_109276" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10615365": { "compartment": "compartment_984", "id": "reaction_10615365", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10615360", "catalyst" ], [ "species_10615363", "inhibitor" ] ], "additional_components": [ "O01302", "WBGene00011362", "Q9U295", "WBGene00000037", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10659441": { "compartment": "compartment_70101", "id": "reaction_10659441", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10659438", "catalyst" ] ], "additional_components": [ "G5EEM9", "WBGene00019747", "G5EED9", "WBGene00010813" ] }, "reaction_10659911": { "compartment": "compartment_12045", "id": "reaction_10659911", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10659908", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "WBGene00010943" ] }, "reaction_10602878": { "compartment": "compartment_7660", "id": "reaction_10602878", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602869", "species_10602874" ], "products": [ "species_10602876" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10664492": { "compartment": "compartment_70101", "id": "reaction_10664492", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664474", "species_10617465" ], "products": [ "species_10664476" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664490": { "compartment": "compartment_17947", "id": "reaction_10664490", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664476", "species_10617443" ], "products": [ "species_10664478" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "WBGene00004193", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664488": { "compartment": "compartment_17947", "id": "reaction_10664488", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664478" ], "products": [ "species_10664486", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004193", "WBGene00004201" ] }, "reaction_10657346": { "compartment": "compartment_70101", "id": "reaction_10657346", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657343", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657341": { "compartment": "compartment_70101", "id": "reaction_10657341", "reactome": "R-CEL-8848338", "name": "PNPLA4 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10643167": { "compartment": "compartment_70101", "id": "reaction_10643167", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643163", "species_8876730" ], "products": [ "species_10643165" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_8876730", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10657349": { "compartment": "compartment_70101", "id": "reaction_10657349", "reactome": "R-CEL-8848355", "name": "PNPLA4 hydrolyzes retinyl palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2534407", "species_29356" ], "products": [ "species_8848337", "species_30209" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10664778": { "compartment": "compartment_70101", "id": "reaction_10664778", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664735", "species_10664774" ], "products": [ "species_10664776" ], "modifiers": [], "additional_components": [ "Q21746", "WBGene00019893", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10664366": { "compartment": "compartment_17947", "id": "reaction_10664366", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664361" ], "products": [ "species_10628859", "species_10664363" ], "modifiers": [ [ "species_10664361", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10664355": { "compartment": "compartment_17947", "id": "reaction_10664355", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664321", "species_10664319" ], "products": [ "species_10664323" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034" ] }, "reaction_10664353": { "compartment": "compartment_17947", "id": "reaction_10664353", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664323" ], "products": [ "species_10664351", "species_10662601" ], "modifiers": [], "additional_components": [ "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198" ] }, "reaction_10664944": { "compartment": "compartment_70101", "id": "reaction_10664944", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664940", "species_10664735" ], "products": [ "species_10664942" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10625255": { "compartment": "compartment_70101", "id": "reaction_10625255", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10625216", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10625195": { "compartment": "compartment_70101", "id": "reaction_10625195", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625192", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10625801": { "compartment": "compartment_917758", "id": "reaction_10625801", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614063", "species_10613945", "species_10614053", "species_10625246", "species_10614048" ], "products": [ "species_10625248" ], "modifiers": [ [ "species_10625246", "catalyst" ] ], "additional_components": [ "WBGene00006798", "WBGene00006750", "WBGene00006757", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10625207": { "compartment": "compartment_917757", "id": "reaction_10625207", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625204", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10607988": { "compartment": "compartment_70101", "id": "reaction_10607988", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607978", "species_29356" ], "products": [ "species_111294", "species_10607968" ], "modifiers": [ [ "species_10607985", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "P81299", "WBGene00000383" ] }, "reaction_10650541": { "compartment": "compartment_984", "id": "reaction_10650541", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10650538", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10657183": { "compartment": "compartment_876", "id": "reaction_10657183", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657179", "species_10657165" ], "products": [ "species_10657181" ], "modifiers": [], "additional_components": [ "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "WBGene00006875", "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "G5ED30", "WBGene00006875", "Q10953", "WBGene00006943" ] }, "reaction_10664096": { "compartment": "compartment_70101", "id": "reaction_10664096", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664158": { "compartment": "compartment_70101", "id": "reaction_10664158", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664108": { "compartment": "compartment_70101", "id": "reaction_10664108", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_111745", "species_9024815" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664098": { "compartment": "compartment_70101", "id": "reaction_10664098", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664102": { "compartment": "compartment_70101", "id": "reaction_10664102", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664104": { "compartment": "compartment_70101", "id": "reaction_10664104", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664100": { "compartment": "compartment_70101", "id": "reaction_10664100", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664106": { "compartment": "compartment_70101", "id": "reaction_10664106", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_9024463", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10648108": { "compartment": "compartment_7660", "id": "reaction_10648108", "reactome": "R-CEL-5686578", "name": "Activated ATM phosphorylates ABL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648103" ], "products": [ "species_113582", "species_10648106" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00000018", "WBGene00000018", "WBGene00000227" ] }, "reaction_10648895": { "compartment": "compartment_7660", "id": "reaction_10648895", "reactome": "R-CEL-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648884" ], "products": [ "species_113582", "species_10647722" ], "modifiers": [ [ "species_10648884", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648892": { "compartment": "compartment_7660", "id": "reaction_10648892", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648889" ], "products": [ "species_113582", "species_10647734" ], "modifiers": [ [ "species_10648889", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647750": { "compartment": "compartment_7660", "id": "reaction_10647750", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10647734" ], "products": [ "species_113550", "species_10647747" ], "modifiers": [ [ "species_10647707", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00001377" ] }, "reaction_10647638": { "compartment": "compartment_7660", "id": "reaction_10647638", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647634" ], "products": [ "species_10647636" ], "modifiers": [], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10647737": { "compartment": "compartment_7660", "id": "reaction_10647737", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647698" ], "products": [ "species_113582", "species_10647707" ], "modifiers": [ [ "species_10647734", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10648897": { "compartment": "compartment_7660", "id": "reaction_10648897", "reactome": "R-CEL-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10647693" ], "products": [ "species_10648889" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647759": { "compartment": "compartment_7660", "id": "reaction_10647759", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647755", "species_10607264", "species_10647734" ], "products": [ "species_10647757" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9BKZ9", "WBGene00001410", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q8WQG9", "WBGene00002178", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "P62784", "WBGene00001875" ] }, "reaction_10647653": { "compartment": "compartment_7660", "id": "reaction_10647653", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647636" ], "products": [ "species_113582", "species_10647650" ], "modifiers": [ [ "species_10647636", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10658362": { "compartment": "compartment_876", "id": "reaction_10658362", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658356", "species_10658351" ], "products": [ "species_10658360" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "P90761", "WBGene00006777" ] }, "reaction_10658873": { "compartment": "compartment_876", "id": "reaction_10658873", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10658793" ], "products": [ "species_10658869" ], "modifiers": [ [ "species_10658871", "inhibitor" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "P34574", "WBGene00011867", "O18014", "WBGene00011381", "Q9N489", "WBGene00022453", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P51485", "WBGene00000195", "Q9U7D5", "WBGene00001519", "Q9BIF4", "WBGene00001224", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "A0A0K3AS36", "Y116A8C.36d", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "species_179856", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10659086": { "compartment": "compartment_876", "id": "reaction_10659086", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659080", "species_10659078" ], "products": [ "species_10659084" ], "modifiers": [], "additional_components": [ "WBGene00006751", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q9XZI6", "WBGene00006751", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10658373": { "compartment": "compartment_876", "id": "reaction_10658373", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658364", "species_10658369" ], "products": [ "species_10658371" ], "modifiers": [], "additional_components": [ "WBGene00000894", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10658436": { "compartment": "compartment_70101", "id": "reaction_10658436", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658432", "species_10658414", "species_10658396" ], "products": [ "species_10658434" ], "modifiers": [], "additional_components": [ "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10658849": { "compartment": "compartment_876", "id": "reaction_10658849", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_10658843" ], "products": [ "species_10658845" ], "modifiers": [ [ "species_10658847", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P34711", "WBGene00006756", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658795": { "compartment": "compartment_876", "id": "reaction_10658795", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10658791" ], "products": [ "species_10658793" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519" ] }, "reaction_10658867": { "compartment": "compartment_876", "id": "reaction_10658867", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658821", "species_10658863" ], "products": [ "species_10658865" ], "modifiers": [], "additional_components": [ "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109" ] }, "reaction_10658441": { "compartment": "compartment_70101", "id": "reaction_10658441", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648614", "species_10658356" ], "products": [ "species_10658396" ], "modifiers": [], "additional_components": [ "WBGene00003587", "WBGene00006777", "WBGene00006777" ] }, "reaction_10658825": { "compartment": "compartment_70101", "id": "reaction_10658825", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658815", "species_10658821" ], "products": [ "species_10658823" ], "modifiers": [], "additional_components": [ "G5EFF7", "WBGene00008852", "P90879", "WBGene00009878", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10665766": { "compartment": "compartment_70101", "id": "reaction_10665766", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_9648300" ], "products": [ "species_10658847" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658439": { "compartment": "compartment_70101", "id": "reaction_10658439", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658434" ], "products": [ "species_10658432", "species_10658414", "species_10648614", "species_10658356" ], "modifiers": [ [ "species_10658434", "catalyst" ] ], "additional_components": [ "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00003587", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10601944": { "compartment": "compartment_70101", "id": "reaction_10601944", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_73566", "species_29356" ], "products": [ "species_29404", "species_111294", "species_111292" ], "modifiers": [ [ "species_10601941", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10665762": { "compartment": "compartment_70101", "id": "reaction_10665762", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10601884" ], "products": [ "species_10601887" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10601903": { "compartment": "compartment_70101", "id": "reaction_10601903", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601889": { "compartment": "compartment_70101", "id": "reaction_10601889", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10601884", "catalyst" ], [ "species_10601887", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10604753": { "compartment": "compartment_70101", "id": "reaction_10604753", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604749" ], "products": [ "species_10601941" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601877": { "compartment": "compartment_70101", "id": "reaction_10601877", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10601874", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10601946": { "compartment": "compartment_70101", "id": "reaction_10601946", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10601926": { "compartment": "compartment_70101", "id": "reaction_10601926", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_111370" ], "products": [ "species_70106", "species_111395" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10601590": { "compartment": "compartment_70101", "id": "reaction_10601590", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601923": { "compartment": "compartment_70101", "id": "reaction_10601923", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111395", "species_29448", "species_113592" ], "products": [ "species_70106", "species_29370", "species_29372", "species_111399" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601941" ], "products": [ "species_10604749" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601934": { "compartment": "compartment_70101", "id": "reaction_10601934", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10601931", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10601593": { "compartment": "compartment_70101", "id": "reaction_10601593", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601900": { "compartment": "compartment_70101", "id": "reaction_10601900", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601913": { "compartment": "compartment_70101", "id": "reaction_10601913", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10604785": { "compartment": "compartment_70101", "id": "reaction_10604785", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10604782", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_109496" ] }, "reaction_10601603": { "compartment": "compartment_70101", "id": "reaction_10601603", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76633", "species_76632" ], "modifiers": [ [ "species_10601600", "catalyst" ] ], "additional_components": [ "species_73524", "O01815", "WBGene00020932" ] }, "reaction_10644465": { "compartment": "compartment_876", "id": "reaction_10644465", "reactome": "R-CEL-5602080", "name": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644461", "species_10605673" ], "products": [ "species_10644463" ], "modifiers": [], "additional_components": [ "species_977180", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "species_977180", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10658612": { "compartment": "compartment_70101", "id": "reaction_10658612", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29408", "species_29366" ], "modifiers": [ [ "species_10658609", "catalyst" ] ], "additional_components": [ "A0A061AD47", "WBGene00013289", "species_113596" ] }, "reaction_10628378": { "compartment": "compartment_5460", "id": "reaction_10628378", "reactome": "R-CEL-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10628375", "catalyst" ] ], "additional_components": [ "WBGene00014058" ] }, "reaction_10623673": { "compartment": "compartment_70101", "id": "reaction_10623673", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623615" ], "products": [ "species_10623671" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10613311": { "compartment": "compartment_984", "id": "reaction_10613311", "reactome": "R-CEL-204824", "name": "Interaction of Tie2 and Ang4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613307" ], "products": [ "species_10613309" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10618750": { "compartment": "compartment_70101", "id": "reaction_10618750", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10628230": { "compartment": "compartment_70101", "id": "reaction_10628230", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628228" ], "products": [ "species_10628138" ], "modifiers": [], "additional_components": [ "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230" ] }, "reaction_10618759": { "compartment": "compartment_70101", "id": "reaction_10618759", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618742", "species_10618746", "species_10610070" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10605677": { "compartment": "compartment_984", "id": "reaction_10605677", "reactome": "R-CEL-140791", "name": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605667", "species_10605556" ], "products": [ "species_10605675" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10614194": { "compartment": "compartment_70101", "id": "reaction_10614194", "reactome": "R-CEL-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10614189", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613017": { "compartment": "compartment_20699", "id": "reaction_10613017", "reactome": "R-CEL-204500", "name": "CyP60 chaperones Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613013", "species_10613008" ], "products": [ "species_10613015" ], "modifiers": [], "additional_components": [ "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "P52012", "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10613023": { "compartment": "compartment_20699", "id": "reaction_10613023", "reactome": "R-CEL-204549", "name": "Caveolin-1 binds Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613008", "species_10613019" ], "products": [ "species_10613021" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "WBGene00000301", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q94051", "WBGene00000301" ] }, "reaction_10605482": { "compartment": "compartment_70101", "id": "reaction_10605482", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10604943", "species_114519" ], "products": [ "species_10605480" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10620840": { "compartment": "compartment_70101", "id": "reaction_10620840", "reactome": "R-CEL-432143", "name": "PECAM-1 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10610622" ], "products": [ "species_10620838" ], "modifiers": [], "additional_components": [ "WBGene00006820", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "O01761", "WBGene00006820" ] }, "reaction_10618110": { "compartment": "compartment_876", "id": "reaction_10618110", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605490" ], "products": [ "species_10605439", "species_10605064", "species_10604843" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10623452": { "compartment": "compartment_876", "id": "reaction_10623452", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623438" ], "products": [ "species_10623450" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471" ] }, "reaction_10612267": { "compartment": "compartment_876", "id": "reaction_10612267", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612263", "species_10612257", "species_266099" ], "products": [ "species_10612265" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929" ] }, "reaction_10613785": { "compartment": "compartment_876", "id": "reaction_10613785", "reactome": "R-CEL-210285", "name": "Trans-homophilic interaction of PECAM-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613781" ], "products": [ "species_10613783" ], "modifiers": [], "additional_components": [ "WBGene00006820", "O01761", "WBGene00006820" ] }, "reaction_10618771": { "compartment": "compartment_70101", "id": "reaction_10618771", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618767" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613301": { "compartment": "compartment_876", "id": "reaction_10613301", "reactome": "R-CEL-204798", "name": "Interaction of Tie2 and p85 of PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602421" ], "products": [ "species_10613299" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613325": { "compartment": "compartment_876", "id": "reaction_10613325", "reactome": "R-CEL-204871", "name": "Interaction of Tie2 and Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602400" ], "products": [ "species_10613323" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004774", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10620439": { "compartment": "compartment_114584", "id": "reaction_10620439", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29372", "species_114565" ], "modifiers": [ [ "species_10620436", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10628226": { "compartment": "compartment_70101", "id": "reaction_10628226", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628152", "species_10628147" ], "products": [ "species_10628154" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10628373": { "compartment": "compartment_7660", "id": "reaction_10628373", "reactome": "R-CEL-1008200", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628369", "species_1008228" ], "products": [ "species_10628371" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521", "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521" ] }, "reaction_10628113": { "compartment": "compartment_70101", "id": "reaction_10628113", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628107", "species_10628102" ], "products": [ "species_10628111" ], "modifiers": [], "additional_components": [ "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215" ] }, "reaction_10625054": { "compartment": "compartment_70101", "id": "reaction_10625054", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625050", "species_10625045" ], "products": [ "species_10625052" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292" ] }, "reaction_10623288": { "compartment": "compartment_876", "id": "reaction_10623288", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623154" ], "products": [ "species_10623286" ], "modifiers": [], "additional_components": [ "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708", "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708" ] }, "reaction_10605543": { "compartment": "compartment_70101", "id": "reaction_10605543", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10605540", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10613779": { "compartment": "compartment_70101", "id": "reaction_10613779", "reactome": "R-CEL-210283", "name": "Interaction of PECAM-1 and PLC gamma1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10612156" ], "products": [ "species_10613777" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004038", "Q22070", "WBGene00004038", "O01761", "WBGene00006820" ] }, "reaction_10613000": { "compartment": "compartment_876", "id": "reaction_10613000", "reactome": "R-CEL-204434", "name": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10612996" ], "products": [ "species_10612998" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10621291": { "compartment": "compartment_70101", "id": "reaction_10621291", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10602421", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10666074": { "compartment": "compartment_984", "id": "reaction_10666074", "reactome": "R-CEL-9708859", "name": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666070" ], "products": [ "species_10666072", "species_10618735" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10618769": { "compartment": "compartment_70101", "id": "reaction_10618769", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10618763", "species_10610070" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613800": { "compartment": "compartment_70101", "id": "reaction_10613800", "reactome": "R-CEL-210291", "name": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613783" ], "products": [ "species_29370", "species_10613789" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "O01761", "WBGene00006820", "O01761", "WBGene00006820", "WBGene00005077" ] }, "reaction_10621374": { "compartment": "compartment_70101", "id": "reaction_10621374", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621366", "species_29438" ], "products": [ "species_10621368", "species_29420" ], "modifiers": [ [ "species_10621371", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q03206", "ced-10", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10623417": { "compartment": "compartment_876", "id": "reaction_10623417", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623365" ], "products": [ "species_10623415" ], "modifiers": [], "additional_components": [ "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "CHEBI:15996", "species_111349", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986", "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29420", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "species_29438", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986" ] }, "reaction_10628271": { "compartment": "compartment_70101", "id": "reaction_10628271", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628267", "species_10604862" ], "products": [ "species_10628269" ], "modifiers": [], "additional_components": [ "Q10955", "WBGene00004348", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "Q10955", "WBGene00004348", "P21137", "WBGene00002189", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052" ] }, "reaction_10605796": { "compartment": "compartment_984", "id": "reaction_10605796", "reactome": "R-CEL-141046", "name": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605792", "species_10605556" ], "products": [ "species_10605794" ], "modifiers": [], "additional_components": [ "WBGene00020921", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "G5EBU2", "WBGene00020921", "species_74016" ] }, "reaction_10605559": { "compartment": "compartment_984", "id": "reaction_10605559", "reactome": "R-CEL-114697", "name": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605545" ], "products": [ "species_10605439", "species_10605547" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10613027": { "compartment": "compartment_876", "id": "reaction_10613027", "reactome": "R-CEL-204600", "name": "Basigin homodimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925" ], "products": [ "species_10613025" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10659424": { "compartment": "compartment_12045", "id": "reaction_10659424", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869214", "species_29356" ], "products": [ "species_8869207", "species_29416" ], "modifiers": [ [ "species_10659421", "catalyst" ] ], "additional_components": [ "Q22943", "WBGene00003907", "G5EGT1", "WBGene00003906" ] }, "reaction_10665500": { "compartment": "compartment_17957", "id": "reaction_10665500", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665498" ], "products": [ "species_10623242" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618108": { "compartment": "compartment_876", "id": "reaction_10618108", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605439", "species_10605486" ], "products": [ "species_10605488" ], "modifiers": [], "additional_components": [ "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10605492": { "compartment": "compartment_70101", "id": "reaction_10605492", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605488" ], "products": [ "species_29420", "species_10605490" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10644326": { "compartment": "compartment_984", "id": "reaction_10644326", "reactome": "R-CEL-5578883", "name": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644322", "species_10605556" ], "products": [ "species_10644324" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10605697": { "compartment": "compartment_984", "id": "reaction_10605697", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605695", "species_9693058" ], "products": [ "species_10605667" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10628243": { "compartment": "compartment_17906", "id": "reaction_10628243", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628237" ], "products": [ "species_10628241" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10612983": { "compartment": "compartment_876", "id": "reaction_10612983", "reactome": "R-CEL-204392", "name": "Basigin binds MCT1, MCT3 and MCT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612973", "species_10612925" ], "products": [ "species_10612981" ], "modifiers": [], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10628232": { "compartment": "compartment_70101", "id": "reaction_10628232", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628170" ], "products": [ "species_10628178" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10638020": { "compartment": "compartment_876", "id": "reaction_10638020", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638016", "species_10638011" ], "products": [ "species_10638018" ], "modifiers": [], "additional_components": [ "WBGene00008800", "WBGene00009500", "Q19459", "WBGene00008800", "A0A1N7SYP5", "WBGene00009500" ] }, "reaction_10613297": { "compartment": "compartment_984", "id": "reaction_10613297", "reactome": "R-CEL-204779", "name": "Interaction of Tie2 with Ang1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613107" ], "products": [ "species_10613295" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10612243": { "compartment": "compartment_876", "id": "reaction_10612243", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612239", "species_10612233" ], "products": [ "species_10612241" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10620845": { "compartment": "compartment_70101", "id": "reaction_10620845", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10620842", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00005077" ] }, "reaction_10620455": { "compartment": "compartment_876", "id": "reaction_10620455", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620453" ], "products": [ "species_10605540" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10605787": { "compartment": "compartment_984", "id": "reaction_10605787", "reactome": "R-CEL-140872", "name": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605742" ], "products": [ "species_10605785", "species_9693058" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214" ] }, "reaction_10621362": { "compartment": "compartment_70101", "id": "reaction_10621362", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621354" ], "products": [ "species_10621356", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887" ] }, "reaction_10618757": { "compartment": "compartment_70101", "id": "reaction_10618757", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618754" ], "modifiers": [ [ "species_10618748", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10621249": { "compartment": "compartment_876", "id": "reaction_10621249", "reactome": "R-CEL-435244", "name": "PECAM1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613781" ], "products": [ "species_29370", "species_10613771" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00006820" ] }, "reaction_10605527": { "compartment": "compartment_70101", "id": "reaction_10605527", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605516" ], "products": [ "species_29370", "species_10605524" ], "modifiers": [ [ "species_10605480", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O44412", "WBGene00020298", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10664445": { "compartment": "compartment_984", "id": "reaction_10664445", "reactome": "R-CEL-9603302", "name": "Factor IIa inhibitors (peptide) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603327", "species_10605556" ], "products": [ "species_10664443" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6458", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6458", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470" ] }, "reaction_10605745": { "compartment": "compartment_876", "id": "reaction_10605745", "reactome": "R-CEL-140870", "name": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605675" ], "products": [ "species_10605742" ], "modifiers": [ [ "species_10605675", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618765": { "compartment": "compartment_70101", "id": "reaction_10618765", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10618735" ], "products": [ "species_10618763" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10613775": { "compartment": "compartment_70101", "id": "reaction_10613775", "reactome": "R-CEL-210277", "name": "Interaction of PECAM-1 and SHP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10613445" ], "products": [ "species_10613773" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004214", "G5EC24", "WBGene00004214", "O01761", "WBGene00006820" ] }, "reaction_10613321": { "compartment": "compartment_984", "id": "reaction_10613321", "reactome": "R-CEL-204863", "name": "Interaction of Tie2 with Ang2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613317" ], "products": [ "species_10613319" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628426": { "compartment": "compartment_70101", "id": "reaction_10628426", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628420", "species_10628422" ], "products": [ "species_10628424" ], "modifiers": [], "additional_components": [ "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "O62422", "WBGene00012532" ] }, "reaction_10618744": { "compartment": "compartment_70101", "id": "reaction_10618744", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10618735" ], "products": [ "species_10618742" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10628222": { "compartment": "compartment_70101", "id": "reaction_10628222", "reactome": "R-CEL-983266", "name": "Kinesins bind microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_10628216" ], "products": [ "species_10628218" ], "modifiers": [], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q9XU12", "WBGene00002219", "Q965T6", "WBGene00002230", "Q8MQ03", "WBGene00006974", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "P34540", "WBGene00006840", "P23678", "WBGene00006831", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "H9G2T2", "WBGene00002214", "G5EBX0", "WBGene00002228", "Q9XUS9", "WBGene00000875", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10663939": { "compartment": "compartment_984", "id": "reaction_10663939", "reactome": "R-CEL-9015379", "name": "Factor IIa inhibitors (compounds) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603311", "species_10605556" ], "products": [ "species_10663937" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "species_74016", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760" ] }, "reaction_10605466": { "compartment": "compartment_70101", "id": "reaction_10605466", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605453" ], "products": [ "species_10605463", "species_29420" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "WBGene00016570" ] }, "reaction_10615894": { "compartment": "compartment_876", "id": "reaction_10615894", "reactome": "R-CEL-375133", "name": "Basigin binds Mannose-carrying cell recognition molecules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615890" ], "products": [ "species_10615892" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q5WRR1", "WBGene00006942", "H2KZ60", "WBGene00016354" ] }, "reaction_10628291": { "compartment": "compartment_7660", "id": "reaction_10628291", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628287", "species_10628276" ], "products": [ "species_10628289" ], "modifiers": [], "additional_components": [ "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00000414", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34618", "WBGene00000414" ] }, "reaction_10618114": { "compartment": "compartment_876", "id": "reaction_10618114", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605463" ], "products": [ "species_10618112", "species_10605439", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10628300": { "compartment": "compartment_70101", "id": "reaction_10628300", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628296", "species_10625052" ], "products": [ "species_10628298" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "Q21301", "WBGene00010641" ] }, "reaction_10614187": { "compartment": "compartment_876", "id": "reaction_10614187", "reactome": "R-CEL-210881", "name": "Dimerization of Tie2/Ang1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613295" ], "products": [ "species_10614185" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10615042": { "compartment": "compartment_161320", "id": "reaction_10615042", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615034" ], "products": [ "species_10615040" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642" ] }, "reaction_10628341": { "compartment": "compartment_7660", "id": "reaction_10628341", "reactome": "R-CEL-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628337", "species_10628314" ], "products": [ "species_10628339" ], "modifiers": [], "additional_components": [ "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278" ] }, "reaction_10621346": { "compartment": "compartment_70101", "id": "reaction_10621346", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621334" ], "products": [ "species_10621336", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ], [ "species_10621344", "catalyst" ], [ "species_10621342", "inhibitor" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179856" ] }, "reaction_10628396": { "compartment": "compartment_74700", "id": "reaction_10628396", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628392", "species_10628383" ], "products": [ "species_10628394" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "W6SBE5", "WBGene00021538", "G5ECC3", "WBGene00004373" ] }, "reaction_10628220": { "compartment": "compartment_70101", "id": "reaction_10628220", "reactome": "R-CEL-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10628218" ], "products": [ "species_29370", "species_10628218" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10628224": { "compartment": "compartment_70101", "id": "reaction_10628224", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628143" ], "products": [ "species_10628145" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10623550": { "compartment": "compartment_876", "id": "reaction_10623550", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623520" ], "products": [ "species_10623548" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491", "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491" ] }, "reaction_10613808": { "compartment": "compartment_876", "id": "reaction_10613808", "reactome": "R-CEL-210304", "name": "Interaction of integrin alphaVbeta3 with PECAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10613781" ], "products": [ "species_10613806" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00006820", "Q27874", "WBGene00003930", "O01761", "WBGene00006820", "P34446", "WBGene00003929" ] }, "reaction_10614191": { "compartment": "compartment_70101", "id": "reaction_10614191", "reactome": "R-CEL-210974", "name": "Interaction of SOS-1 to Tie2 bound Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10613323" ], "products": [ "species_10614189" ], "modifiers": [], "additional_components": [ "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628941": { "compartment": "compartment_70101", "id": "reaction_10628941", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628847", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628811" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628943": { "compartment": "compartment_7660", "id": "reaction_10628943", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10628853" ], "products": [ "species_159942", "species_159939", "species_10628909" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628945": { "compartment": "compartment_70101", "id": "reaction_10628945", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628807", "species_10628835" ], "products": [ "species_10628863" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628939": { "compartment": "compartment_70101", "id": "reaction_10628939", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628931" ], "products": [ "species_10628818" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727" ] }, "reaction_10628921": { "compartment": "compartment_7660", "id": "reaction_10628921", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628907", "species_10628917" ], "products": [ "species_10628919" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628866": { "compartment": "compartment_70101", "id": "reaction_10628866", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10628863" ], "products": [ "species_10628859", "species_10628837" ], "modifiers": [ [ "species_10628863", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628887": { "compartment": "compartment_7660", "id": "reaction_10628887", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628855", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10628874" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628934": { "compartment": "compartment_7660", "id": "reaction_10628934", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628927", "species_10628919" ], "products": [ "species_10628931", "species_10628925" ], "modifiers": [ [ "species_10628919", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628843": { "compartment": "compartment_70101", "id": "reaction_10628843", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628839" ], "products": [ "species_10597908", "species_10628841" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "P0CG71", "WBGene00006727", "WBGene00006727", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628937": { "compartment": "compartment_70101", "id": "reaction_10628937", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628849", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628814" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10636006": { "compartment": "compartment_161320", "id": "reaction_10636006", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10636003", "catalyst" ] ], "additional_components": [ "O16454", "WBGene00007055", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "P52717", "WBGene00018271", "Q8MYN7", "WBGene00012681", "P43510", "WBGene00000786", "O17255", "WBGene00044760", "O01530", "WBGene00000219", "G5EEI4", "WBGene00000214", "Q9BL26", "WBGene00044760", "P52716", "WBGene00017969", "Q86NE0", "WBGene00000215", "P52715", "WBGene00008741", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O76725", "WBGene00021503", "O01532", "WBGene00000218", "P52714", "WBGene00007462", "Q2AAB9", "WBGene00044760", "Q22972", "WBGene00017881", "Q09991", "WBGene00019605", "G5EC01", "WBGene00077655", "U4PME4", "WBGene00044760" ] }, "reaction_10636398": { "compartment": "compartment_161320", "id": "reaction_10636398", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10636395", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10627920": { "compartment": "compartment_70101", "id": "reaction_10627920", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627918" ], "products": [ "species_983123", "species_10627781" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627946": { "compartment": "compartment_70101", "id": "reaction_10627946", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627851", "species_10627943" ], "products": [ "species_10627853", "species_10627941" ], "modifiers": [ [ "species_10627851", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344" ] }, "reaction_10618106": { "compartment": "compartment_70101", "id": "reaction_10618106", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615172" ], "products": [ "species_10618104" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10618097": { "compartment": "compartment_70101", "id": "reaction_10618097", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10628615": { "compartment": "compartment_876", "id": "reaction_10628615", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10628612", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10617865": { "compartment": "compartment_70101", "id": "reaction_10617865", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610909", "species_29356" ], "products": [ "species_10617862", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10627952": { "compartment": "compartment_70101", "id": "reaction_10627952", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627853", "species_10627859" ], "products": [ "species_10627851", "species_111294", "species_76577", "species_10627918" ], "modifiers": [ [ "species_10627859", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", 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"WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627954": { "compartment": "compartment_70101", "id": "reaction_10627954", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00001236", "Q20617", "WBGene00006719", "P34284", "WBGene00015350", "Q93349", "WBGene00007985", "Q9N3G1", "WBGene00021815", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "O62200", "WBGene00018654", "A0A2K5ATR7", "WBGene00022450", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q9U1Q1", "WBGene00006709", "P91404", "WBGene00019993", "O45495", "WBGene00006730", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q2WF61", "WBGene00044345", "Q9N5S5", "WBGene00018654", "Q17720", "WBGene00006717", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "A0A4V0IJV5", "WBGene00021406", "P91133", "WBGene00016326", "Q2AAC0", "WBGene00022168", "G5EG38", "WBGene00001281", "P34441", "WBGene00001284", "Q93903", "WBGene00001583", "Q17911", "WBGene00007529", "Q9U1U4", "WBGene00006714", "Q03607", "WBGene00018654", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q9N373", "WBGene00002278", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "Q17583", "WBGene00007252", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "Q18931", "WBGene00006703", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "A8DJA6", "WBGene00021721" ] }, "reaction_10628074": { "compartment": "compartment_70101", "id": "reaction_10628074", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10628071", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q09541", "WBGene00017686", "Q22531", "WBGene00022073" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_10618070" ], "products": [ "species_10618072" ], "modifiers": [ [ "species_10625485", "inhibitor" ] ], "additional_components": [ "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10627949": { "compartment": "compartment_70101", "id": "reaction_10627949", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627941", "species_29926", "species_10597908" ], "products": [ "species_10627943", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10627941", "catalyst" ] ], "additional_components": [ "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882" ] }, "reaction_10628590": { "compartment": "compartment_70101", "id": "reaction_10628590", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10605468", "species_114519" ], "products": [ "species_10605476" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10625498": { "compartment": "compartment_70101", "id": "reaction_10625498", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_113592" ], "products": [ "species_29370", "species_10625485" ], "modifiers": [ [ "species_10625495", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "P21137", "WBGene00002189", "H2KYN2", "WBGene00015650" ] }, "reaction_10612908": { "compartment": "compartment_12045", "id": "reaction_10612908", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612652", "species_10612904" ], "products": [ "species_10612906" ], "modifiers": [], "additional_components": [ "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "species_29438", "Q23445", "WBGene00022678" ] }, "reaction_10627862": { "compartment": "compartment_70101", "id": "reaction_10627862", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627855" ], "products": [ "species_10627851", "species_111294", "species_10627859", "species_76577" ], "modifiers": [ [ "species_10627781", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q9XUS3", "WBGene00003967", "Q95XX0", "WBGene00006708", "Q65XX2", "WBGene00021831", "Q21633", "WBGene00006713", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q09291", "WBGene00009738", "Q9TZ69", "WBGene00006715", "O45323", "WBGene00008439", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q9N2W9", "WBGene00006705", "Q17750", "WBGene00015555", 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"Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627910": { "compartment": "compartment_17957", "id": "reaction_10627910", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032", "species_113592", "species_29356" ], "products": [ "species_983034", "species_29370", "species_29372" ], "modifiers": [ [ "species_10627907", "catalyst" ] ], "additional_components": [ "O18227", "WBGene00001818", "Q9TZD9", "WBGene00001814", "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O44897", "WBGene00001819" ] }, "reaction_10627922": { "compartment": "compartment_70101", "id": "reaction_10627922", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_983036", "species_8942986", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628040": { "compartment": "compartment_17957", "id": "reaction_10628040", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10628037", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q22531", "WBGene00022073" ] }, "reaction_10618074": { "compartment": "compartment_70101", "id": "reaction_10618074", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615172" ], "products": [ "species_10615247", "species_111294" ], "modifiers": [ [ "species_10618061", "catalyst" ], [ "species_10618072", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_29420", "Q18246", "WBGene00004307", "H2L055", "WBGene00018734", "H2L2C2", "WBGene00012100", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920" ] }, "reaction_10633105": { "compartment": "compartment_876", "id": "reaction_10633105", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633263": { "compartment": "compartment_876", "id": "reaction_10633263", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633260", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "species_74016", "G5EDP9", "WBGene00000001", "species_266099", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10659805": { "compartment": "compartment_20699", "id": "reaction_10659805", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614984", "species_10659801", "species_1806217" ], "products": [ "species_10659803" ], "modifiers": [], "additional_components": [ "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806217", "Q9BKS2", "WBGene00022347", "G5EFK4", "WBGene00000183" ] }, "reaction_10656373": { "compartment": "compartment_70101", "id": "reaction_10656373", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656346", "species_10633219" ], "products": [ "species_10656371" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633324": { "compartment": "compartment_876", "id": "reaction_10633324", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633290": { "compartment": "compartment_876", "id": "reaction_10633290", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633287", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10656350": { "compartment": "compartment_70101", "id": "reaction_10656350", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656341", "species_10656346" ], "products": [ "species_10656348" ], "modifiers": [], "additional_components": [ "F53A2.8a", "WBGene00003479", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633206": { "compartment": "compartment_876", "id": "reaction_10633206", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10633203", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10656378": { "compartment": "compartment_876", "id": "reaction_10656378", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633035": { "compartment": "compartment_876", "id": "reaction_10633035", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633224": { "compartment": "compartment_876", "id": "reaction_10633224", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633132": { "compartment": "compartment_876", "id": "reaction_10633132", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10633316": { "compartment": "compartment_876", "id": "reaction_10633316", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10633313", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633243": { "compartment": "compartment_876", "id": "reaction_10633243", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633240", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10656381": { "compartment": "compartment_876", "id": "reaction_10656381", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633282": { "compartment": "compartment_876", "id": "reaction_10633282", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633311": { "compartment": "compartment_876", "id": "reaction_10633311", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633293": { "compartment": "compartment_876", "id": "reaction_10633293", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10633080": { "compartment": "compartment_876", "id": "reaction_10633080", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10633213": { "compartment": "compartment_876", "id": "reaction_10633213", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10605252": { "compartment": "compartment_7660", "id": "reaction_10605252", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605235" ], "products": [ "species_10601853", "species_10605250" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605237": { "compartment": "compartment_7660", "id": "reaction_10605237", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605233", "species_10605191", "species_10605151", "species_10605168", "species_10601853", "species_10605156", "species_10605228", "species_10605223" ], "products": [ "species_10605235" ], "modifiers": [], "additional_components": [ "WBGene00001259", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "Q9U3I0", "WBGene00009078", "Q9N554", "WBGene00021281", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00012000", "WBGene00008729", "P90783", "WBGene00008338", "G5EBY0", "WBGene00009103", "Q17431", "WBGene00007110", "A5Z2V7", "WBGene00008533", "Q9N5U5", "WBGene00018064", "Q03560", "WBGene00007184", "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10605248": { "compartment": "compartment_7660", "id": "reaction_10605248", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10605131", "species_10599967" ], "products": [ "species_10605241", "species_10601853" ], "modifiers": [ [ "species_10605131", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479" ] }, "reaction_10605284": { "compartment": "compartment_7660", "id": "reaction_10605284", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605250" ], "products": [ "species_9757634", "species_10605262" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605126", "species_10605241" ], "products": [ "species_10605243" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605266": { "compartment": "compartment_7660", "id": "reaction_10605266", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605262" ], "products": [ "species_10605264" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602928": { "compartment": "compartment_70101", "id": "reaction_10602928", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602925", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611542": { "compartment": "compartment_70101", "id": "reaction_10611542", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611530" ], "products": [ "species_29370", "species_10611537" ], "modifiers": [ [ "species_10611539", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10611550": { "compartment": "compartment_17927", "id": "reaction_10611550", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10611547", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10606867": { "compartment": "compartment_876", "id": "reaction_10606867", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10606864", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660206": { "compartment": "compartment_70101", "id": "reaction_10660206", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10611530", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611457": { "compartment": "compartment_70616", "id": "reaction_10611457", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10611454", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10645970": { "compartment": "compartment_13949", "id": "reaction_10645970", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645966", "species_10644752" ], "products": [ "species_10645968" ], "modifiers": [], "additional_components": [ "species_29438", "O01803", "WBGene00004274", "WBGene00010045", "Q20759", "WBGene00010045", "species_29438", "O01803", "WBGene00004274" ] }, "reaction_10640972": { "compartment": "compartment_876", "id": "reaction_10640972", "reactome": "R-CEL-4088218", "name": "Tetrastatin binds integrin alphaVbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10630428" ], "products": [ "species_10640970" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614491": { "compartment": "compartment_984", "id": "reaction_10614491", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614485", "species_10614487" ], "products": [ "species_10614489" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614512": { "compartment": "compartment_984", "id": "reaction_10614512", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614477", "species_10614508" ], "products": [ "species_10614510" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10640917": { "compartment": "compartment_876", "id": "reaction_10640917", "reactome": "R-CEL-4085083", "name": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640889", "species_10640891" ], "products": [ "species_10640915" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614720": { "compartment": "compartment_984", "id": "reaction_10614720", "reactome": "R-CEL-265426", "name": "Interaction of integrin alphaVbeta3 with Tenascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10614506" ], "products": [ "species_10614718" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614895": { "compartment": "compartment_984", "id": "reaction_10614895", "reactome": "R-CEL-349593", "name": "Interaction of integrin alphaIIbbeta3 with Fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10605504" ], "products": [ "species_10614893" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10623717": { "compartment": "compartment_5460", "id": "reaction_10623717", "reactome": "R-CEL-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113552", "species_113557" ], "modifiers": [ [ "species_10623712", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10598702": { "compartment": "compartment_70101", "id": "reaction_10598702", "reactome": "R-CEL-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10598697", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10619814": { "compartment": "compartment_70101", "id": "reaction_10619814", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10619801", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910" ] }, "reaction_10631293": { "compartment": "compartment_7660", "id": "reaction_10631293", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10611173", "species_10607873" ], "products": [ "species_10631291" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10622295": { "compartment": "compartment_876", "id": "reaction_10622295", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622293" ], "products": [ "species_10622291", "species_10622230" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "Q17446", "WBGene00004055", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10622324": { "compartment": "compartment_7660", "id": "reaction_10622324", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622320", "species_10622241" ], "products": [ "species_10622322" ], "modifiers": [], "additional_components": [ "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "Q9U325", "WBGene00003182", "Q9U325", "WBGene00003182", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948" ] }, "reaction_10615948": { "compartment": "compartment_876", "id": "reaction_10615948", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615942", "species_10615944" ], "products": [ "species_10615946" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10622246": { "compartment": "compartment_7660", "id": "reaction_10622246", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622214", "species_10622230" ], "products": [ "species_113582", "species_10622243" ], "modifiers": [ [ "species_10622230", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10666234": { "compartment": "compartment_17957", "id": "reaction_10666234", "reactome": "R-CEL-9737780", "name": "MTTP binds lomitapide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9737774", "species_10666230" ], "products": [ "species_10666232" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "CHEBI:16247", "species_171126", "G5ECG7", "WBGene00001099", "Q17770", "WBGene00003963", "CHEBI:16247", "species_9737774", "species_171126", "G5ECG7", "WBGene00001099" ] }, "reaction_10659889": { "compartment": "compartment_7660", "id": "reaction_10659889", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659881" ], "products": [ "species_10659887" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659903": { "compartment": "compartment_20699", "id": "reaction_10659903", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659901" ], "products": [ "species_10659897" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659885": { "compartment": "compartment_20699", "id": "reaction_10659885", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659879" ], "products": [ "species_10659881", "species_10659883" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10637200": { "compartment": "compartment_984", "id": "reaction_10637200", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10631810" ], "products": [ "species_10637198" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "WBGene00001403", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "O77469", "WBGene00001403" ] }, "reaction_10660724": { "compartment": "compartment_70101", "id": "reaction_10660724", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10660721", "catalyst" ] ], "additional_components": [ "O45719", "WBGene00021956", "Q95XV3", "WBGene00021956" ] }, "reaction_10663928": { "compartment": "compartment_70101", "id": "reaction_10663928", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10663931": { "compartment": "compartment_70101", "id": "reaction_10663931", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627109": { "compartment": "compartment_70101", "id": "reaction_10627109", "reactome": "R-CEL-977348", "name": "PHGDH tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728", "species_29360" ], "products": [ "species_70106", "species_73473", "species_977329" ], "modifiers": [ [ "species_10627106", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10664421": { "compartment": "compartment_70101", "id": "reaction_10664421", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627088": { "compartment": "compartment_70101", "id": "reaction_10627088", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10627085", "catalyst" ] ], "additional_components": [ "species_109496", "A0A061ACK7", "WBGene00013379" ] }, "reaction_10627099": { "compartment": "compartment_70101", "id": "reaction_10627099", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10627096", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10635804": { "compartment": "compartment_70101", "id": "reaction_10635804", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635794" ], "products": [ "species_10635802" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10644304": { "compartment": "compartment_7660", "id": "reaction_10644304", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10599971", "species_10644300" ], "products": [ "species_10644302" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9N585", "WBGene00004094", "O02092", "WBGene00018391", "O61931", "WBGene00019971", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q27484", "WBGene00001915", "O62275", "WBGene00010263", "Q9N5K2", "WBGene00019246", "P04255", "WBGene00001885", "Q09249", "WBGene00007624", "P09588", "WBGene00001877", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q27485", "WBGene00001909", "H2KZD5", "WBGene00017641", "Q27511", "WBGene00019947", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q10453", "WBGene00001945", "Q9XVI3", "WBGene00011945", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9U3I0", "WBGene00009078", "O16720", "WBGene00000106", "Q27894", "WBGene00001878", "Q17684", "WBGene00007355", "Q27490", "WBGene00001944", "G5ED77", "WBGene00011910", "K7ZUH9", "WBGene00001914", "A0A0U1RML5", "WBGene00018921", "Q19826", "WBGene00017830", "Q21770", "WBGene00011061", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q93338", "WBGene00007971", "Q27876", "WBGene00001922", "Q21691", "WBGene00019862", "G5EEH0", "WBGene00004323", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619797": { "compartment": "compartment_70101", "id": "reaction_10619797", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10612563" ], "products": [ "species_10619794" ], "modifiers": [ [ "species_10612563", "catalyst" ] ], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10635806": { "compartment": "compartment_70101", "id": "reaction_10635806", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619794" ], "products": [ "species_10635794" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10664156": { "compartment": "compartment_70101", "id": "reaction_10664156", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635780" ], "products": [ "species_10664153" ], "modifiers": [ [ "species_10635780", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910" ] }, "reaction_10632756": { "compartment": "compartment_70101", "id": "reaction_10632756", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632730": { "compartment": "compartment_70101", "id": "reaction_10632730", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10632727", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10644851": { "compartment": "compartment_70101", "id": "reaction_10644851", "reactome": "R-CEL-5618328", "name": "ATAT acetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_76183" ], "products": [ "species_76194", "species_10644843" ], "modifiers": [ [ "species_10644848", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00003178" ] }, "reaction_10644854": { "compartment": "compartment_70101", "id": "reaction_10644854", "reactome": "R-CEL-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10644843" ], "products": [ "species_10616991", "species_76183" ], "modifiers": [ [ "species_10643031", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00001838" ] }, "reaction_10633770": { "compartment": "compartment_7660", "id": "reaction_10633770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633646": { "compartment": "compartment_7660", "id": "reaction_10633646", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633666": { "compartment": "compartment_7660", "id": "reaction_10633666", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633767": { "compartment": "compartment_7660", "id": "reaction_10633767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633669": { "compartment": "compartment_7660", "id": "reaction_10633669", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633773": { "compartment": "compartment_7660", "id": "reaction_10633773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633591": { "compartment": "compartment_7660", "id": "reaction_10633591", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10633588", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10633761": { "compartment": "compartment_7660", "id": "reaction_10633761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633540": { "compartment": "compartment_7660", "id": "reaction_10633540", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633626": { "compartment": "compartment_7660", "id": "reaction_10633626", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10598876": { "compartment": "compartment_70101", "id": "reaction_10598876", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10598873", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10614940": { "compartment": "compartment_70101", "id": "reaction_10614940", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598873", "species_10614932" ], "products": [ "species_10614938" ], "modifiers": [], "additional_components": [ "WBGene00003844", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844" ] }, "reaction_10605806": { "compartment": "compartment_17951", "id": "reaction_10605806", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141349", "species_141343", "species_113535" ], "products": [ "species_141350", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10614952": { "compartment": "compartment_70101", "id": "reaction_10614952", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10614949", "catalyst" ] ], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615022": { "compartment": "compartment_70101", "id": "reaction_10615022", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10615019", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10615014": { "compartment": "compartment_70101", "id": "reaction_10615014", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10615011", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10615168": { "compartment": "compartment_70101", "id": "reaction_10615168", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614938" ], "products": [ "species_10614932" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "WBGene00022748", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10614964": { "compartment": "compartment_70101", "id": "reaction_10614964", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614958", "species_10614938" ], "products": [ "species_10614962" ], "modifiers": [], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615006": { "compartment": "compartment_70101", "id": "reaction_10615006", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10615004": { "compartment": "compartment_70101", "id": "reaction_10615004", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10605808": { "compartment": "compartment_17951", "id": "reaction_10605808", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_141323", "species_113535" ], "products": [ "species_141324", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10633102": { "compartment": "compartment_172574", "id": "reaction_10633102", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633226": { "compartment": "compartment_172574", "id": "reaction_10633226", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633246": { "compartment": "compartment_172574", "id": "reaction_10633246", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10665730": { "compartment": "compartment_7660", "id": "reaction_10665730", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608179", "species_10598178", "species_10598168", "species_10598173", "species_10598163" ], "products": [ "species_10608181" ], "modifiers": [], "additional_components": [ "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915", "WBGene00004338", "WBGene00004340", "WBGene00004339", "WBGene00018409", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q22664", "WBGene00011915" ] }, "reaction_10665732": { "compartment": "compartment_7660", "id": "reaction_10665732", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608167", "species_10608177", "species_10608172" ], "products": [ "species_10608179" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915" ] }, "reaction_10647775": { "compartment": "compartment_7660", "id": "reaction_10647775", "reactome": "R-CEL-5684081", "name": "MRN complex binds CDK2 and RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10597866", "species_10647771" ], "products": [ "species_10647773" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648902": { "compartment": "compartment_7660", "id": "reaction_10648902", "reactome": "R-CEL-5693608", "name": "Initial resection of double-strand break ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648899", "species_113518" ], "products": [ "species_30555", "species_10648080" ], "modifiers": [ [ "species_10648899", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647796": { "compartment": "compartment_7660", "id": "reaction_10647796", "reactome": "R-CEL-5684140", "name": "ATM phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647783" ], "products": [ "species_113582", "species_10647793" ], "modifiers": [ [ "species_10647783", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647786": { "compartment": "compartment_7660", "id": "reaction_10647786", "reactome": "R-CEL-5684096", "name": "CDK2 phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647773" ], "products": [ "species_113582", "species_10647783", "species_10597866" ], "modifiers": [ [ "species_10647773", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648089": { "compartment": "compartment_7660", "id": "reaction_10648089", "reactome": "R-CEL-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648082" ], "products": [ "species_30555", "species_10648086" ], "modifiers": [ [ "species_10648082", "catalyst" ] ], "additional_components": [ "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "O18017", "WBGene00001865", "Q23255", "WBGene00003405", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "Q9TYU5", "WBGene00007029", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648084": { "compartment": "compartment_7660", "id": "reaction_10648084", "reactome": "R-CEL-5685985", "name": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648026", "species_10648033", "species_10648080" ], "products": [ "species_10648082" ], "modifiers": [], "additional_components": [ "Q9U3F2", "WBGene00001016", "O18017", "WBGene00001865", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "WBGene00001049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648074": { "compartment": "compartment_7660", "id": "reaction_10648074", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10648066" ], "products": [ "species_427498", "species_427497", "species_10647771" ], "modifiers": [ [ "species_10648071", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10605272": { "compartment": "compartment_7660", "id": "reaction_10605272", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605124", "species_10603872" ], "products": [ "species_10605126" ], "modifiers": [], "additional_components": [ "WBGene00005014", "WBGene00005015", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014" ] }, "reaction_10605282": { "compartment": "compartment_7660", "id": "reaction_10605282", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605254" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605274": { "compartment": "compartment_7660", "id": "reaction_10605274", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605173", "species_10605178" ], "products": [ "species_10605180" ], "modifiers": [], "additional_components": [ "WBGene00001236", "WBGene00001235", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236" ] }, "reaction_10605280": { "compartment": "compartment_7660", "id": "reaction_10605280", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605245" ], "products": [ "species_10605245" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602932": { "compartment": "compartment_7660", "id": "reaction_10602932", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602930" ], "products": [ "species_10599973", "species_110068", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605286": { "compartment": "compartment_7660", "id": "reaction_10605286", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602944": { "compartment": "compartment_7660", "id": "reaction_10602944", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602934" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10605268": { "compartment": "compartment_7660", "id": "reaction_10605268", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605161", "species_10605166" ], "products": [ "species_10605168" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849" ] }, "reaction_10605288": { "compartment": "compartment_7660", "id": "reaction_10605288", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602069": { "compartment": "compartment_7660", "id": "reaction_10602069", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602067" ], "products": [ "species_10599973", "species_109877", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605276": { "compartment": "compartment_7660", "id": "reaction_10605276", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605180", "species_10605185" ], "products": [ "species_10605191" ], "modifiers": [], "additional_components": [ "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "WBGene00010990", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990" ] }, "reaction_10603082": { "compartment": "compartment_7660", "id": "reaction_10603082", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603080" ], "products": [ "species_10599973", "species_75897", "species_10601853", "species_10602065" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998" ] }, "reaction_10605270": { "compartment": "compartment_7660", "id": "reaction_10605270", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605107", "species_10605093" ], "products": [ "species_10605109" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "P34425", "WBGene00000507", "WBGene00000410", "O17869", "WBGene00009650", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410" ] }, "reaction_10605256": { "compartment": "compartment_7660", "id": "reaction_10605256", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605254" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605260": { "compartment": "compartment_7660", "id": "reaction_10605260", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605258" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10614605": { "compartment": "compartment_984", "id": "reaction_10614605", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10614602", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10613943": { "compartment": "compartment_984", "id": "reaction_10613943", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10613940", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "O01661", "WBGene00000368", "P34374", "WBGene00006772", "A0A3B1E663", "WBGene00006742", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10658294": { "compartment": "compartment_12045", "id": "reaction_10658294", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10658288" ], "products": [ "species_10658292" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10658322": { "compartment": "compartment_70101", "id": "reaction_10658322", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10648879" ], "products": [ "species_10658320" ], "modifiers": [], "additional_components": [ "species_163579", "CHEBI:16247", "species_171126", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_163579", "CHEBI:16247", "species_171126", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10634349": { "compartment": "compartment_12045", "id": "reaction_10634349", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10634342" ], "products": [ "species_159751", "species_10634346", "species_1650769" ], "modifiers": [ [ "species_10634340", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10634558": { "compartment": "compartment_984", "id": "reaction_10634558", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634519" ], "products": [ "species_10630807" ], "modifiers": [ [ "species_10634551", "catalyst" ], [ "species_10634556", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "O61901", "WBGene00020954", "Q20176", "WBGene00003555", "O61901", "WBGene00020954" ] }, "reaction_10634538": { "compartment": "compartment_984", "id": "reaction_10634538", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634443" ], "products": [ "species_10634519" ], "modifiers": [ [ "species_10634535", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q20176", "WBGene00003555", "Q19791", "WBGene00001650" ] }, "reaction_10634367": { "compartment": "compartment_17957", "id": "reaction_10634367", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10634360" ], "products": [ "species_10634364", "species_158602" ], "modifiers": [ [ "species_10634360", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10606608": { "compartment": "compartment_7660", "id": "reaction_10606608", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606604" ], "products": [ "species_10606606" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10606694": { "compartment": "compartment_70101", "id": "reaction_10606694", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606606" ], "products": [ "species_10606604" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10665614": { "compartment": "compartment_70101", "id": "reaction_10665614", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10614140": { "compartment": "compartment_984", "id": "reaction_10614140", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10614137", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10598798": { "compartment": "compartment_70101", "id": "reaction_10598798", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_31633" ], "products": [ "species_29370", "species_29472", "species_29372" ], "modifiers": [ [ "species_10598795", "catalyst" ] ], "additional_components": [ "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603", "Q9U307", "WBGene00001604", "Q95YD1", "WBGene00001602", "O02225", "WBGene00001607" ] }, "reaction_10636583": { "compartment": "compartment_70101", "id": "reaction_10636583", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731226", "species_29356" ], "products": [ "species_70106", "species_9731235", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636540": { "compartment": "compartment_70101", "id": "reaction_10636540", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10636537", "catalyst" ] ], "additional_components": [ "species_109496", "O61902", "WBGene00003579" ] }, "reaction_10636577": { "compartment": "compartment_70101", "id": "reaction_10636577", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9731304" ], "products": [ "species_70106", "species_9731298", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636580": { "compartment": "compartment_70101", "id": "reaction_10636580", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731300", "species_29356" ], "products": [ "species_70106", "species_9731296", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636550": { "compartment": "compartment_5460", "id": "reaction_10636550", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_159448", "species_2393950" ], "modifiers": [ [ "species_10636547", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_109496" ] }, "reaction_10625790": { "compartment": "compartment_70101", "id": "reaction_10625790", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625786", "species_10625769" ], "products": [ "species_10625788", "species_10625767" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542" ] }, "reaction_10625798": { "compartment": "compartment_876", "id": "reaction_10625798", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625796", "species_10625767" ], "products": [ "species_10625794", "species_10625769" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "species_179838", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542" ] }, "reaction_10625792": { "compartment": "compartment_70101", "id": "reaction_10625792", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625788", "species_10625721" ], "products": [ "species_10625727", "species_10625786" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "species_179838", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "P0CG71", "WBGene00006727", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193" ] }, "reaction_10617081": { "compartment": "compartment_984", "id": "reaction_10617081", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617006" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_380873", "species_10614053", "species_10615845" ], "modifiers": [ [ "species_10617006", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10643190": { "compartment": "compartment_70101", "id": "reaction_10643190", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617022", "species_10617017", "species_10617012" ], "products": [ "species_10617028" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615848": { "compartment": "compartment_984", "id": "reaction_10615848", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615843" ], "products": [ "species_10614130", "species_10614132", "species_10613945", "species_10614086", "species_10614116", "species_10614053", "species_374935", "species_10615845" ], "modifiers": [ [ "species_10615843", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10655657": { "compartment": "compartment_161320", "id": "reaction_10655657", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10655654", "catalyst" ] ], "additional_components": [ "CHEBI:71464", "CHEBI:85262", "CHEBI:71466", "CHEBI:85263", "CHEBI:85299", "species_5693752", "CHEBI:16196", "CHEBI:30805", "species_8934421", "species_422506", "species_390435", "CHEBI:28875", "Q9GUI1", "WBGene00021917" ] }, "reaction_10615853": { "compartment": "compartment_876", "id": "reaction_10615853", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048", "species_10615841" ], "products": [ "species_10615843" ], "modifiers": [ [ "species_10615841", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617030": { "compartment": "compartment_70101", "id": "reaction_10617030", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10616993", "species_10614053", "species_10614048" ], "products": [ "species_10617006" ], "modifiers": [ [ "species_10616993", "catalyst" ], [ "species_10617028", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615379": { "compartment": "compartment_374932", "id": "reaction_10615379", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10654711": { "compartment": "compartment_161320", "id": "reaction_10654711", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10654708", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10657921": { "compartment": "compartment_161320", "id": "reaction_10657921", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10657918", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10657916": { "compartment": "compartment_161320", "id": "reaction_10657916", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10657913", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10646383": { "compartment": "compartment_7660", "id": "reaction_10646383", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10646374" ], "products": [ "species_10646380", "species_113541" ], "modifiers": [ [ "species_10646374", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "species_266099", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10599229": { "compartment": "compartment_5460", "id": "reaction_10599229", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10599226", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10620180": { "compartment": "compartment_20699", "id": "reaction_10620180", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_29356" ], "products": [ "species_8934421", "species_428248" ], "modifiers": [ [ "species_10620177", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10636098": { "compartment": "compartment_70101", "id": "reaction_10636098", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142811" ], "products": [ "species_2142678", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10604164": { "compartment": "compartment_70101", "id": "reaction_10604164", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10604161", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_109496", "Q93934", "WBGene00011128" ] }, "reaction_10604092": { "compartment": "compartment_5460", "id": "reaction_10604092", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604812": { "compartment": "compartment_70101", "id": "reaction_10604812", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10617876": { "compartment": "compartment_17951", "id": "reaction_10617876", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10617873", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10651381": { "compartment": "compartment_5460", "id": "reaction_10651381", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797920", "species_6797917" ], "modifiers": [ [ "species_10651378", "catalyst" ] ], "additional_components": [ "species_113596", "A0A486WWC6", "WBGene00021355" ] }, "reaction_10665635": { "compartment": "compartment_70101", "id": "reaction_10665635", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10665629" ], "products": [ "species_10665631" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10601956": { "compartment": "compartment_5460", "id": "reaction_10601956", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10601953", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10601613": { "compartment": "compartment_70101", "id": "reaction_10601613", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10601610", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633842": { "compartment": "compartment_70101", "id": "reaction_10633842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861764", "species_29356" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10633839", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10599441": { "compartment": "compartment_70101", "id": "reaction_10599441", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_31311", "species_29356" ], "products": [ "species_70106", "species_73473", "species_31369" ], "modifiers": [ [ "species_10599438", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10602155": { "compartment": "compartment_70101", "id": "reaction_10602155", "reactome": "R-CEL-74215", "name": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_500260", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "species_113599", "species_83956", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10614847": { "compartment": "compartment_876", "id": "reaction_10614847", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266013", "species_109276" ], "products": [ "species_210382", "species_266074" ], "modifiers": [ [ "species_10614844", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10609829": { "compartment": "compartment_5460", "id": "reaction_10609829", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10609826", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10648965": { "compartment": "compartment_12045", "id": "reaction_10648965", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_29768", "species_1498751" ], "modifiers": [ [ "species_10648962", "catalyst" ] ], "additional_components": [ "WBGene00012750" ] }, "reaction_10613738": { "compartment": "compartment_70101", "id": "reaction_10613738", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_209794", "species_71285" ], "modifiers": [ [ "species_10613735", "catalyst" ] ], "additional_components": [ "P34254", "WBGene00015124", "Q20308", "WBGene00018340", "Q22279", "WBGene00011573" ] }, "reaction_10603959": { "compartment": "compartment_5460", "id": "reaction_10603959", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10623581": { "compartment": "compartment_70101", "id": "reaction_10623581", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482627", "species_113592" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10623578", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10602160": { "compartment": "compartment_70101", "id": "reaction_10602160", "reactome": "R-CEL-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10602157", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:57667", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10614546": { "compartment": "compartment_17960", "id": "reaction_10614546", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10614543", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_109496", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10638233": { "compartment": "compartment_5460", "id": "reaction_10638233", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10638230", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10603995": { "compartment": "compartment_5460", "id": "reaction_10603995", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77308" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10643274": { "compartment": "compartment_876", "id": "reaction_10643274", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10643271", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10630841": { "compartment": "compartment_70101", "id": "reaction_10630841", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10664496": { "compartment": "compartment_17963", "id": "reaction_10664496", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664676": { "compartment": "compartment_17963", "id": "reaction_10664676", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9604808" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10664673", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "O62115", "WBGene00011780", "H2L0F4", "WBGene00044618", "G5ECA6", "WBGene00011780", "O17750", "WBGene00011780", "Q9XU74", "WBGene00011780", "O02310", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62165", "WBGene00011780", "Q20575", "WBGene00009849", "O62375", "WBGene00011780", "G5EDB3", "WBGene00044630", "O62163", "WBGene00011780", "O02231", "WBGene00011780", "O62114", "WBGene00011780", "Q8MQG4", "WBGene00011780" ] }, "reaction_10660515": { "compartment": "compartment_17963", "id": "reaction_10660515", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10660512", "catalyst" ] ], "additional_components": [ "WBGene00000267" ] }, "reaction_10635654": { "compartment": "compartment_70101", "id": "reaction_10635654", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632925" ], "products": [ "species_10632931" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10606792": { "compartment": "compartment_5460", "id": "reaction_10606792", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10606780" ], "products": [ "species_10606782" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10658283": { "compartment": "compartment_12045", "id": "reaction_10658283", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10658280", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10633575": { "compartment": "compartment_70101", "id": "reaction_10633575", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10620259": { "compartment": "compartment_70101", "id": "reaction_10620259", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10635604": { "compartment": "compartment_12045", "id": "reaction_10635604", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10649513": { "compartment": "compartment_12045", "id": "reaction_10649513", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10649510", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10601689": { "compartment": "compartment_70101", "id": "reaction_10601689", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633672": { "compartment": "compartment_70101", "id": "reaction_10633672", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10602203": { "compartment": "compartment_70101", "id": "reaction_10602203", "reactome": "R-CEL-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10604102": { "compartment": "compartment_5460", "id": "reaction_10604102", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_109990", "species_113529" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10604099", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10602864": { "compartment": "compartment_70101", "id": "reaction_10602864", "reactome": "R-CEL-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10601577", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:58069", "CHEBI:58593", "species_727810", "species_109378", "species_109402", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10662674": { "compartment": "compartment_70101", "id": "reaction_10662674", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10662671", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10601633": { "compartment": "compartment_70101", "id": "reaction_10601633", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10599656": { "compartment": "compartment_70101", "id": "reaction_10599656", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599579", "species_113592" ], "products": [ "species_29370", "species_10599584" ], "modifiers": [ [ "species_10599653", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "P04630", "WBGene00000285", "P34335", "WBGene00015754", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "H2L0I6", "WBGene00022059", "O02159", "WBGene00020378", "Q9N3L4", "WBGene00021753", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10598455": { "compartment": "compartment_70101", "id": "reaction_10598455", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10598452", "catalyst" ] ], "additional_components": [ "Q564Q1", "WBGene00008132", "species_29360" ] }, "reaction_10649967": { "compartment": "compartment_5460", "id": "reaction_10649967", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10648292": { "compartment": "compartment_12045", "id": "reaction_10648292", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10648289", "catalyst" ] ], "additional_components": [ "WBGene00017515" ] }, "reaction_10620296": { "compartment": "compartment_70101", "id": "reaction_10620296", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10620293", "catalyst" ] ], "additional_components": [ "Q10022", "WBGene00020895", "Q19403", "WBGene00008749", "H2KZD1", "WBGene00018756" ] }, "reaction_10617789": { "compartment": "compartment_17951", "id": "reaction_10617789", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633115": { "compartment": "compartment_12045", "id": "reaction_10633115", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10633112", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10599096": { "compartment": "compartment_5460", "id": "reaction_10599096", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599093", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10633675": { "compartment": "compartment_70101", "id": "reaction_10633675", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10610954": { "compartment": "compartment_70101", "id": "reaction_10610954", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10610951", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10602188": { "compartment": "compartment_70101", "id": "reaction_10602188", "reactome": "R-CEL-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10663917": { "compartment": "compartment_70101", "id": "reaction_10663917", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10663914", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10637076": { "compartment": "compartment_70101", "id": "reaction_10637076", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10632691": { "compartment": "compartment_17957", "id": "reaction_10632691", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_1606280", "species_428256" ], "modifiers": [ [ "species_10632688", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_109496" ] }, "reaction_10650255": { "compartment": "compartment_70101", "id": "reaction_10650255", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10657188": { "compartment": "compartment_876", "id": "reaction_10657188", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10657185", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10636091": { "compartment": "compartment_12045", "id": "reaction_10636091", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10665955": { "compartment": "compartment_70101", "id": "reaction_10665955", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10665952", "catalyst" ] ], "additional_components": [ "O01927", "WBGene00007549", "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "Q18545", "WBGene00008033" ] }, "reaction_10649446": { "compartment": "compartment_876", "id": "reaction_10649446", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10649443", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649074": { "compartment": "compartment_5460", "id": "reaction_10649074", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10649053" ], "products": [ "species_5693984", "species_10649066", "species_5693978" ], "modifiers": [ [ "species_10649071", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10650376": { "compartment": "compartment_7660", "id": "reaction_10650376", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10650373", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00008458" ] }, "reaction_10599073": { "compartment": "compartment_70101", "id": "reaction_10599073", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10599070", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10604569": { "compartment": "compartment_70101", "id": "reaction_10604569", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10604566", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10665633": { "compartment": "compartment_70101", "id": "reaction_10665633", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665631" ], "products": [ "species_189386", "species_10665629" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10614855": { "compartment": "compartment_876", "id": "reaction_10614855", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10632904": { "compartment": "compartment_20699", "id": "reaction_10632904", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_744227" ], "products": [ "species_205687", "species_1660674" ], "modifiers": [ [ "species_10632901", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10658932": { "compartment": "compartment_7660", "id": "reaction_10658932", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10658929", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_216667", "Q09374", "WBGene00022673" ] }, "reaction_10648973": { "compartment": "compartment_13977", "id": "reaction_10648973", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693747", "species_5693752" ], "products": [ "species_5693733", "species_5693736" ], "modifiers": [ [ "species_10648970", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10598743": { "compartment": "compartment_70101", "id": "reaction_10598743", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_29406" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10625839": { "compartment": "compartment_876", "id": "reaction_10625839", "reactome": "R-CEL-917892", "name": "FLVCR1-1 transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71185" ], "products": [ "species_917877" ], "modifiers": [ [ "species_10625836", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10633276": { "compartment": "compartment_12045", "id": "reaction_10633276", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10633273", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10620499": { "compartment": "compartment_70101", "id": "reaction_10620499", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates CERT1-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620471", "species_113592" ], "products": [ "species_29370", "species_10620474" ], "modifiers": [ [ "species_10620496", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "O45818", "WBGene00012019", "Q9XUJ7", "WBGene00012352" ] }, "reaction_10625298": { "compartment": "compartment_5460", "id": "reaction_10625298", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_113557", "species_159549" ], "modifiers": [ [ "species_10625295", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10646515": { "compartment": "compartment_5668575", "id": "reaction_10646515", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10602200": { "compartment": "compartment_70101", "id": "reaction_10602200", "reactome": "R-CEL-74249", "name": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500245", "species_29372" ], "products": [ "species_500244", "species_83956" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "species_112016", "CHEBI:58576", "U4PSA1", "WBGene00019298" ] }, "reaction_10598754": { "compartment": "compartment_5460", "id": "reaction_10598754", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10656850": { "compartment": "compartment_70101", "id": "reaction_10656850", "reactome": "R-CEL-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10613758": { "compartment": "compartment_70101", "id": "reaction_10613758", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_159362", "species_113528" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10649405": { "compartment": "compartment_5460", "id": "reaction_10649405", "reactome": "R-CEL-5695980", "name": "ACAD10 dehydrogenates S-2MPDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695946", "species_113596" ], "products": [ "species_5695949", "species_31649" ], "modifiers": [ [ "species_10649402", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10648981": { "compartment": "compartment_12045", "id": "reaction_10648981", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10648978", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10603973": { "compartment": "compartment_5460", "id": "reaction_10603973", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10620208": { "compartment": "compartment_70101", "id": "reaction_10620208", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10637073": { "compartment": "compartment_70101", "id": "reaction_10637073", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10615384": { "compartment": "compartment_5460", "id": "reaction_10615384", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10615381", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10598437": { "compartment": "compartment_70101", "id": "reaction_10598437", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_109496" ] }, "reaction_10602986": { "compartment": "compartment_17951", "id": "reaction_10602986", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390404", "species_390426" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10601687": { "compartment": "compartment_70101", "id": "reaction_10601687", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10613721": { "compartment": "compartment_1462052", "id": "reaction_10613721", "reactome": "R-CEL-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351603", "species_351597", "species_351599" ], "modifiers": [ [ "species_10613718", "catalyst" ] ], "additional_components": [ "Q9XTQ6", "WBGene00006541", "CHEBI:18315", "CHEBI:28694" ] }, "reaction_10598445": { "compartment": "compartment_70101", "id": "reaction_10598445", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_30170" ], "products": [ "species_29548", "species_29452" ], "modifiers": [ [ "species_10598442", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10599677": { "compartment": "compartment_70101", "id": "reaction_10599677", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599664" ], "products": [ "species_10599669" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10632966": { "compartment": "compartment_20699", "id": "reaction_10632966", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632960" ], "products": [ "species_10632925" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10656397": { "compartment": "compartment_171062", "id": "reaction_10656397", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10656388", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10646163": { "compartment": "compartment_17963", "id": "reaction_10646163", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10646160", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00043980" ] }, "reaction_10613668": { "compartment": "compartment_984", "id": "reaction_10613668", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10598667": { "compartment": "compartment_5460", "id": "reaction_10598667", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113557", "species_113593" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10598664", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_199207", "species_266099" ] }, "reaction_10603955": { "compartment": "compartment_5460", "id": "reaction_10603955", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10648947": { "compartment": "compartment_17957", "id": "reaction_10648947", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10636081": { "compartment": "compartment_12045", "id": "reaction_10636081", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10636078", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "H2KYS3", "WBGene00000905", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620190": { "compartment": "compartment_70101", "id": "reaction_10620190", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428198", "species_428193" ], "modifiers": [ [ "species_10620187", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10598847": { "compartment": "compartment_5460", "id": "reaction_10598847", "reactome": "R-CEL-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10598844", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10631244": { "compartment": "compartment_70101", "id": "reaction_10631244", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10631239", "catalyst" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10601643": { "compartment": "compartment_70101", "id": "reaction_10601643", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633758": { "compartment": "compartment_70101", "id": "reaction_10633758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10662836": { "compartment": "compartment_70101", "id": "reaction_10662836", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10662833", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10633620": { "compartment": "compartment_70101", "id": "reaction_10633620", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10633617", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10603977": { "compartment": "compartment_5460", "id": "reaction_10603977", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10657668": { "compartment": "compartment_984", "id": "reaction_10657668", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936165", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851369" ], "modifiers": [ [ "species_10657665", "catalyst" ] ], "additional_components": [ "species_29420", "species_29370", "CHEBI:58069", "species_205687", "species_727810", "species_76577", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10599797": { "compartment": "compartment_70101", "id": "reaction_10599797", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10599794", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10623690": { "compartment": "compartment_5460", "id": "reaction_10623690", "reactome": "R-CEL-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10623685", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10617879": { "compartment": "compartment_17951", "id": "reaction_10617879", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390419", "species_390440" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10660679": { "compartment": "compartment_984", "id": "reaction_10660679", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10660676", "catalyst" ] ], "additional_components": [ "O01811", "WBGene00003170", "species_74016", "Q966L1", "WBGene00017089", "Q2V071", "WBGene00044697", "B1V898", "WBGene00077701", "Q21427", "WBGene00010775" ] }, "reaction_10646108": { "compartment": "compartment_70101", "id": "reaction_10646108", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_5652213" ], "products": [ "species_70106", "species_73473", "species_29532" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10622852": { "compartment": "compartment_70101", "id": "reaction_10622852", "reactome": "R-CEL-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622850" ], "products": [ "species_10599579", "species_76577" ], "modifiers": [], "additional_components": [ "species_76577", "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696" ] }, "reaction_10659921": { "compartment": "compartment_5460", "id": "reaction_10659921", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524038", "species_113559" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10659918", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10606630": { "compartment": "compartment_7660", "id": "reaction_10606630", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602999" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00011543", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10632627": { "compartment": "compartment_161320", "id": "reaction_10632627", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10632624", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10650017": { "compartment": "compartment_70101", "id": "reaction_10650017", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784964", "species_29356" ], "products": [ "species_561052", "species_29702" ], "modifiers": [ [ "species_10650014", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10632606": { "compartment": "compartment_161320", "id": "reaction_10632606", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10632603", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10604965": { "compartment": "compartment_70101", "id": "reaction_10604965", "reactome": "R-CEL-112033", "name": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_500172", "species_29372" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:28997", "species_83927", "U4PSA1", "WBGene00019298" ] }, "reaction_10630856": { "compartment": "compartment_5460", "id": "reaction_10630856", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113521" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620269": { "compartment": "compartment_984", "id": "reaction_10620269", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10620266", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10599499": { "compartment": "compartment_70101", "id": "reaction_10599499", "reactome": "R-CEL-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10599496", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10660470": { "compartment": "compartment_5668575", "id": "reaction_10660470", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10660467", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10623783": { "compartment": "compartment_5460", "id": "reaction_10623783", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_113552", "species_113529", "species_113593" ], "products": [ "species_31339", "species_113548", "species_113563", "species_113581" ], "modifiers": [ [ "species_10623780", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10633623": { "compartment": "compartment_70101", "id": "reaction_10633623", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10603991": { "compartment": "compartment_5460", "id": "reaction_10603991", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10633658": { "compartment": "compartment_70101", "id": "reaction_10633658", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629746", "species_29356" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633578": { "compartment": "compartment_70101", "id": "reaction_10633578", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023943", "species_29356" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10633566", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10598621": { "compartment": "compartment_70101", "id": "reaction_10598621", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598618", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "G5EBJ7", "WBGene00001404", "species_109496" ] }, "reaction_10635652": { "compartment": "compartment_7660", "id": "reaction_10635652", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632943", "species_10635648" ], "products": [ "species_10632941", "species_10635650" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10620130": { "compartment": "compartment_70101", "id": "reaction_10620130", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10620127", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10602133": { "compartment": "compartment_5460", "id": "reaction_10602133", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10602130", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10604815": { "compartment": "compartment_70101", "id": "reaction_10604815", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10604793" ], "products": [ "species_10604790", "species_111745" ], "modifiers": [ [ "species_10604793", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10598741": { "compartment": "compartment_5460", "id": "reaction_10598741", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "Q23621", "WBGene00014095" ] }, "reaction_10633764": { "compartment": "compartment_70101", "id": "reaction_10633764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10635606": { "compartment": "compartment_17957", "id": "reaction_10635606", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10651363": { "compartment": "compartment_70101", "id": "reaction_10651363", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29642", "species_29356" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10651360", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10664533": { "compartment": "compartment_17963", "id": "reaction_10664533", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10601948": { "compartment": "compartment_5460", "id": "reaction_10601948", "reactome": "R-CEL-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10601673": { "compartment": "compartment_70101", "id": "reaction_10601673", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109382", "species_111355" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10601670", "catalyst" ] ], "additional_components": [ "Q9N588", "WBGene00022455", "species_109496" ] }, "reaction_10599471": { "compartment": "compartment_70101", "id": "reaction_10599471", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10599468", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10649413": { "compartment": "compartment_5460", "id": "reaction_10649413", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5690531", "species_113593" ], "products": [ "species_159448", "species_5690542", "species_159450" ], "modifiers": [ [ "species_10649410", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10633309": { "compartment": "compartment_171062", "id": "reaction_10633309", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806238", "species_29356" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10602123": { "compartment": "compartment_5460", "id": "reaction_10602123", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10602120", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10615281": { "compartment": "compartment_5460", "id": "reaction_10615281", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10615278", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10604557": { "compartment": "compartment_70101", "id": "reaction_10604557", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "species_727810", "species_76577", "species_109378", "species_109386", "Q09629", "WBGene00014058" ] }, "reaction_10637079": { "compartment": "compartment_70101", "id": "reaction_10637079", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10666203": { "compartment": "compartment_70101", "id": "reaction_10666203", "reactome": "R-CEL-9731661", "name": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_9731609" ], "products": [ "species_9731659", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10632609": { "compartment": "compartment_161320", "id": "reaction_10632609", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632564", "species_1605610" ], "products": [ "species_10632566" ], "modifiers": [ [ "species_10632564", "catalyst" ] ], "additional_components": [ "WBGene00021095", "O02106", "WBGene00021095", "species_1605610", "WBGene00021095" ] }, "reaction_10633583": { "compartment": "compartment_70101", "id": "reaction_10633583", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10649455": { "compartment": "compartment_5460", "id": "reaction_10649455", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10649452", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10648824": { "compartment": "compartment_12045", "id": "reaction_10648824", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10648821", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10656394": { "compartment": "compartment_70101", "id": "reaction_10656394", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656386" ], "products": [ "species_10656392" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00021683", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10603953": { "compartment": "compartment_5460", "id": "reaction_10603953", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10603950", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10660930": { "compartment": "compartment_70101", "id": "reaction_10660930", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10660927", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10598766": { "compartment": "compartment_5460", "id": "reaction_10598766", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10630854": { "compartment": "compartment_5460", "id": "reaction_10630854", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_29376", "species_113521" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10649384": { "compartment": "compartment_70101", "id": "reaction_10649384", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29666" ], "products": [ "species_191293", "species_111294", "species_76577" ], "modifiers": [ [ "species_10649381", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10664694": { "compartment": "compartment_17963", "id": "reaction_10664694", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10598427": { "compartment": "compartment_70101", "id": "reaction_10598427", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10598424", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10635656": { "compartment": "compartment_70101", "id": "reaction_10635656", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632931", "species_10614210" ], "products": [ "species_10632933" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10657379": { "compartment": "compartment_12045", "id": "reaction_10657379", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598731": { "compartment": "compartment_70101", "id": "reaction_10598731", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76213", "species_29404" ], "products": [ "species_29448", "species_29406" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10610944": { "compartment": "compartment_70101", "id": "reaction_10610944", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10646517": { "compartment": "compartment_5668572", "id": "reaction_10646517", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10614529": { "compartment": "compartment_17960", "id": "reaction_10614529", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10614526", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10665612": { "compartment": "compartment_70101", "id": "reaction_10665612", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10655768": { "compartment": "compartment_70101", "id": "reaction_10655768", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10655765", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10601685": { "compartment": "compartment_70101", "id": "reaction_10601685", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10613756": { "compartment": "compartment_984", "id": "reaction_10613756", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10599279": { "compartment": "compartment_5460", "id": "reaction_10599279", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10599276", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10632693": { "compartment": "compartment_161320", "id": "reaction_10632693", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10649944": { "compartment": "compartment_5460", "id": "reaction_10649944", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10649941", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10623815": { "compartment": "compartment_70101", "id": "reaction_10623815", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_113578" ], "products": [ "species_29602", "species_29366", "species_31633" ], "modifiers": [ [ "species_10623812", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10646519": { "compartment": "compartment_5668572", "id": "reaction_10646519", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10630837": { "compartment": "compartment_70101", "id": "reaction_10630837", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620211": { "compartment": "compartment_70101", "id": "reaction_10620211", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10656412": { "compartment": "compartment_70101", "id": "reaction_10656412", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10633755": { "compartment": "compartment_876", "id": "reaction_10633755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633752", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "Q17848", "WBGene00002146" ] }, "reaction_10647415": { "compartment": "compartment_70101", "id": "reaction_10647415", "reactome": "R-CEL-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "CHEBI:16427", "CHEBI:18392", "CHEBI:16427", "CHEBI:18392", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10605609": { "compartment": "compartment_17957", "id": "reaction_10605609", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10605606", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10636567": { "compartment": "compartment_5460", "id": "reaction_10636567", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636563", "species_10630212" ], "products": [ "species_10636565", "species_10630208", "species_113529" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_31649", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9U1X0", "WBGene00013376", "species_113596", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10666187": { "compartment": "compartment_70101", "id": "reaction_10666187", "reactome": "R-CEL-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10614764": { "compartment": "compartment_876", "id": "reaction_10614764", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10614761", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10601653": { "compartment": "compartment_70101", "id": "reaction_10601653", "reactome": "R-CEL-73596", "name": "dCMP + H2O => dUMP + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_109378", "species_29356" ], "products": [ "species_109382", "species_31633" ], "modifiers": [ [ "species_10601650", "catalyst" ] ], "additional_components": [ "P30648", "WBGene00014034" ] }, "reaction_10615392": { "compartment": "compartment_70101", "id": "reaction_10615392", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10647362": { "compartment": "compartment_70101", "id": "reaction_10647362", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10647359", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10633327": { "compartment": "compartment_171062", "id": "reaction_10633327", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10633169", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10620557": { "compartment": "compartment_20699", "id": "reaction_10620557", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10620554", "catalyst" ] ], "additional_components": [ "WBGene00004894" ] }, "reaction_10606787": { "compartment": "compartment_5460", "id": "reaction_10606787", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606782" ], "products": [ "species_113521", "species_10606784" ], "modifiers": [ [ "species_10606782", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10662486": { "compartment": "compartment_5460", "id": "reaction_10662486", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10662483", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10606790": { "compartment": "compartment_5460", "id": "reaction_10606790", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606784", "species_163953" ], "products": [ "species_10606780", "species_113529", "species_113593" ], "modifiers": [ [ "species_10606784", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10599491": { "compartment": "compartment_70101", "id": "reaction_10599491", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10620185": { "compartment": "compartment_70101", "id": "reaction_10620185", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10651159": { "compartment": "compartment_5460", "id": "reaction_10651159", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651143", "species_10649049" ], "products": [ "species_10649051", "species_10651151" ], "modifiers": [ [ "species_10651156", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00009918", "WBGene00009918", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00001590" ] }, "reaction_10620261": { "compartment": "compartment_70101", "id": "reaction_10620261", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10656406": { "compartment": "compartment_70101", "id": "reaction_10656406", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656402" ], "products": [ "species_10656404" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00003477", "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10662852": { "compartment": "compartment_70101", "id": "reaction_10662852", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10662849", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10657682": { "compartment": "compartment_528865", "id": "reaction_10657682", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851509", "species_8851517" ], "products": [ "species_8851518", "species_8851513", "species_5228597" ], "modifiers": [ [ "species_10657679", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_29470", "species_29420", "species_205687", "CHEBI:58069", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10630215": { "compartment": "compartment_5460", "id": "reaction_10630215", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630201", "species_379721", "species_10630208" ], "products": [ "species_379697", "species_10630210", "species_10630212" ], "modifiers": [ [ "species_10630201", "catalyst" ], [ "species_10630208", "catalyst" ] ], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "CHEBI:33739", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33737", "Q9NA32", "WBGene00013532", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10662828": { "compartment": "compartment_12045", "id": "reaction_10662828", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10662825", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10657539": { "compartment": "compartment_70101", "id": "reaction_10657539", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10657536", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_5334668", "species_6810408", "species_1806200", "WBGene00012353" ] }, "reaction_10651392": { "compartment": "compartment_5460", "id": "reaction_10651392", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10651389", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10633516": { "compartment": "compartment_70101", "id": "reaction_10633516", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10657655": { "compartment": "compartment_17963", "id": "reaction_10657655", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851227", "species_425969", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "species_109366", "species_727810", "species_109402", "species_113578", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10599431": { "compartment": "compartment_70101", "id": "reaction_10599431", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_29424", "species_31311" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10615273": { "compartment": "compartment_70101", "id": "reaction_10615273", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372364", "species_76190" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10601717": { "compartment": "compartment_70101", "id": "reaction_10601717", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10601714", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10599461": { "compartment": "compartment_70101", "id": "reaction_10599461", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10599458", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10633638": { "compartment": "compartment_70101", "id": "reaction_10633638", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10598867": { "compartment": "compartment_5460", "id": "reaction_10598867", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10598864", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10604743": { "compartment": "compartment_70101", "id": "reaction_10604743", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10601610", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633655": { "compartment": "compartment_70101", "id": "reaction_10633655", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10599055": { "compartment": "compartment_70101", "id": "reaction_10599055", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10599052", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10612334": { "compartment": "compartment_70101", "id": "reaction_10612334", "reactome": "R-CEL-203565", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612323", "species_10612328" ], "products": [ "species_10612332" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "WBGene00007840", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10657382": { "compartment": "compartment_12045", "id": "reaction_10657382", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598828": { "compartment": "compartment_5460", "id": "reaction_10598828", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10620205": { "compartment": "compartment_70101", "id": "reaction_10620205", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10635608": { "compartment": "compartment_12045", "id": "reaction_10635608", "reactome": "R-CEL-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10611410": { "compartment": "compartment_876", "id": "reaction_10611410", "reactome": "R-CEL-200396", "name": "Creatine transport across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_200381" ], "products": [ "species_83910", "species_29916" ], "modifiers": [ [ "species_10611407", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EF43", "WBGene00004910", "G5EE39", "WBGene00004906" ] }, "reaction_10632713": { "compartment": "compartment_161320", "id": "reaction_10632713", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10632710", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10632580": { "compartment": "compartment_161320", "id": "reaction_10632580", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632566", "species_1605715" ], "products": [ "species_10632564", "species_1605641", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "O02106", "WBGene00021095", "species_1605610", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10660506": { "compartment": "compartment_5460", "id": "reaction_10660506", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660497", "species_10660485" ], "products": [ "species_10660499", "species_10660483" ], "modifiers": [ [ "species_10660504", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "Q9XTU9", "WBGene00013029", "CHEBI:33739", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:49883", "WBGene00013029", "WBGene00001033" ] }, "reaction_10650398": { "compartment": "compartment_70101", "id": "reaction_10650398", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10650395", "catalyst" ] ], "additional_components": [ "species_109496", "O01926", "WBGene00007548" ] }, "reaction_10633649": { "compartment": "compartment_70101", "id": "reaction_10633649", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10656419": { "compartment": "compartment_17951", "id": "reaction_10656419", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10656416", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10657299": { "compartment": "compartment_17957", "id": "reaction_10657299", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657295", "species_8848288" ], "products": [ "species_10657297" ], "modifiers": [], "additional_components": [ "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457", "species_164991", "species_5690542", "species_164991", "species_5690542", "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457" ] }, "reaction_10603989": { "compartment": "compartment_5460", "id": "reaction_10603989", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10602994": { "compartment": "compartment_70101", "id": "reaction_10602994", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_75973" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10602991", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10657658": { "compartment": "compartment_17963", "id": "reaction_10657658", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851233", "species_2022884" ], "products": [ "species_425969", "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29494", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10616356": { "compartment": "compartment_70101", "id": "reaction_10616356", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10599690": { "compartment": "compartment_70101", "id": "reaction_10599690", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599669" ], "products": [ "species_70113", "species_10599687" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10650252": { "compartment": "compartment_70101", "id": "reaction_10650252", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10650249", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10646508": { "compartment": "compartment_5668572", "id": "reaction_10646508", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10646505", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "species_216667", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10598380": { "compartment": "compartment_70101", "id": "reaction_10598380", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10598377", "catalyst" ] ], "additional_components": [ "O44906", "WBGene00021043", "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232" ] }, "reaction_10665624": { "compartment": "compartment_876", "id": "reaction_10665624", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10665621", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10632701": { "compartment": "compartment_161320", "id": "reaction_10632701", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606573", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632698", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10649955": { "compartment": "compartment_70101", "id": "reaction_10649955", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10649952", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10662666": { "compartment": "compartment_5460", "id": "reaction_10662666", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10649957", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10648449": { "compartment": "compartment_5460", "id": "reaction_10648449", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10648446", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q94245", "WBGene00019015", "Q9GYN3", "WBGene00020989" ] }, "reaction_10632945": { "compartment": "compartment_70101", "id": "reaction_10632945", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632933" ], "products": [ "species_10632943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10648429": { "compartment": "compartment_70101", "id": "reaction_10648429", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10648426", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "P34419", "WBGene00018370", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10666184": { "compartment": "compartment_70101", "id": "reaction_10666184", "reactome": "R-CEL-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10613760": { "compartment": "compartment_984", "id": "reaction_10613760", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10657333": { "compartment": "compartment_70101", "id": "reaction_10657333", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10657329" ], "products": [ "species_10657331" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10649964": { "compartment": "compartment_5460", "id": "reaction_10649964", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10649961", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10636076": { "compartment": "compartment_70101", "id": "reaction_10636076", "reactome": "R-CEL-2161791", "name": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142718" ], "products": [ "species_29356", "species_111745", "species_2142707" ], "modifiers": [ [ "species_10636073", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10620511": { "compartment": "compartment_70101", "id": "reaction_10620511", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620474" ], "products": [ "species_29370", "species_10620503" ], "modifiers": [ [ "species_10620508", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10648998": { "compartment": "compartment_876", "id": "reaction_10648998", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10648995", "catalyst" ] ], "additional_components": [ "Q93332", "WBGene00007954", "P91406", "WBGene00020082" ] }, "reaction_10664531": { "compartment": "compartment_17963", "id": "reaction_10664531", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10664528", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10602219": { "compartment": "compartment_70101", "id": "reaction_10602219", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q23588", "WBGene00022817" ] }, "reaction_10664696": { "compartment": "compartment_17963", "id": "reaction_10664696", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10655995": { "compartment": "compartment_13977", "id": "reaction_10655995", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10655992", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649930": { "compartment": "compartment_17951", "id": "reaction_10649930", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10649927", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10606628": { "compartment": "compartment_7660", "id": "reaction_10606628", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10606626" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10633652": { "compartment": "compartment_70101", "id": "reaction_10633652", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10623695": { "compartment": "compartment_876", "id": "reaction_10623695", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10623692", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10646096": { "compartment": "compartment_70101", "id": "reaction_10646096", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636042": { "compartment": "compartment_70101", "id": "reaction_10636042", "reactome": "R-CEL-2161187", "name": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9731626", "species_29356" ], "products": [ "species_29602", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10650368": { "compartment": "compartment_5460", "id": "reaction_10650368", "reactome": "R-CEL-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10650365", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00014058" ] }, "reaction_10654704": { "compartment": "compartment_70101", "id": "reaction_10654704", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6799497" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10654701", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10604818": { "compartment": "compartment_70101", "id": "reaction_10604818", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10665619": { "compartment": "compartment_70101", "id": "reaction_10665619", "reactome": "R-CEL-9661408", "name": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444" ], "products": [ "species_71185" ], "modifiers": [ [ "species_10665616", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10630839": { "compartment": "compartment_876", "id": "reaction_10630839", "reactome": "R-CEL-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10648813": { "compartment": "compartment_70101", "id": "reaction_10648813", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10648810", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10633718": { "compartment": "compartment_70101", "id": "reaction_10633718", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10651186": { "compartment": "compartment_5460", "id": "reaction_10651186", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_10651176", "species_2162265" ], "products": [ "species_6793613", "species_379705", "species_10649049" ], "modifiers": [ [ "species_10651183", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10633187": { "compartment": "compartment_171062", "id": "reaction_10633187", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10664715": { "compartment": "compartment_17963", "id": "reaction_10664715", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10664712", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10603993": { "compartment": "compartment_5460", "id": "reaction_10603993", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10649064": { "compartment": "compartment_5460", "id": "reaction_10649064", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10649049" ], "products": [ "species_29376", "species_10649053" ], "modifiers": [ [ "species_10649061", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10599420": { "compartment": "compartment_5460", "id": "reaction_10599420", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_35139", "species_113533" ], "products": [ "species_29376", "species_113536", "species_113546" ], "modifiers": [ [ "species_10599417", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_113531", "species_198836" ] }, "reaction_10599822": { "compartment": "compartment_70101", "id": "reaction_10599822", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10599819", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10599453": { "compartment": "compartment_70101", "id": "reaction_10599453", "reactome": "R-CEL-71261", "name": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31369", "species_29368", "species_29406" ], "products": [ "species_113528", "species_30235", "species_29434" ], "modifiers": [ [ "species_10599450", "catalyst" ] ], "additional_components": [ "Q19000", "WBGene00001522", "species_113531", "species_198836" ] }, "reaction_10599771": { "compartment": "compartment_70101", "id": "reaction_10599771", "reactome": "R-CEL-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10617719": { "compartment": "compartment_17951", "id": "reaction_10617719", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10617716", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10604547": { "compartment": "compartment_70101", "id": "reaction_10604547", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500077", "species_29370" ], "products": [ "species_500071", "species_113592" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58595", "CHEBI:57673", "species_113578", "WBGene00020190" ] }, "reaction_10632681": { "compartment": "compartment_876", "id": "reaction_10632681", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632678", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_109496" ] }, "reaction_10632559": { "compartment": "compartment_17938", "id": "reaction_10632559", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605592", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632556", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "G5ECR8", "WBGene00008706" ] }, "reaction_10606619": { "compartment": "compartment_7660", "id": "reaction_10606619", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602960" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00009342", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10612354": { "compartment": "compartment_24337", "id": "reaction_10612354", "reactome": "R-CEL-203625", "name": "NOSTRIN mediated translocation of eNOS from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612332" ], "products": [ "species_10612352" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "species_29870", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10606598": { "compartment": "compartment_7660", "id": "reaction_10606598", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10606592" ], "products": [ "species_10606596" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10599269": { "compartment": "compartment_5460", "id": "reaction_10599269", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10610962": { "compartment": "compartment_70101", "id": "reaction_10610962", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10610959", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10634928": { "compartment": "compartment_70101", "id": "reaction_10634928", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_2023974", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10617792": { "compartment": "compartment_17951", "id": "reaction_10617792", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633285": { "compartment": "compartment_171062", "id": "reaction_10633285", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10599247": { "compartment": "compartment_5460", "id": "reaction_10599247", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10599244", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864" ] }, "reaction_10663251": { "compartment": "compartment_70101", "id": "reaction_10663251", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10598857": { "compartment": "compartment_5460", "id": "reaction_10598857", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10665960": { "compartment": "compartment_70101", "id": "reaction_10665960", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10620182", "catalyst" ], [ "species_10665958", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "LigandDisplayForward?ligandId=6625", "LigandDisplayForward?ligandId=10641", "LigandDisplayForward?ligandId=10219", "Q18425", "WBGene00007918", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10633210": { "compartment": "compartment_171062", "id": "reaction_10633210", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806180" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10620172": { "compartment": "compartment_70101", "id": "reaction_10620172", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10620169", "catalyst" ] ], "additional_components": [ "Q7Z139", "WBGene00002044", "G5ED45", "WBGene00002043", "Q9XWE9", "WBGene00006505" ] }, "reaction_10603843": { "compartment": "compartment_70101", "id": "reaction_10603843", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10603840", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10604119": { "compartment": "compartment_70101", "id": "reaction_10604119", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10604116", "catalyst" ] ], "additional_components": [ "species_109382", "species_109366", "species_727810", "species_109378", "species_109402", "species_83928", "CHEBI:17562", "CHEBI:16704", "CHEBI:16450", "CHEBI:15698", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775", "species_109496" ] }, "reaction_10658877": { "compartment": "compartment_70101", "id": "reaction_10658877", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10613692": { "compartment": "compartment_984", "id": "reaction_10613692", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10602198": { "compartment": "compartment_70101", "id": "reaction_10602198", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83927", "CHEBI:17172", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10664494": { "compartment": "compartment_17963", "id": "reaction_10664494", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605607" ], "products": [ "species_9605394", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10633555": { "compartment": "compartment_70101", "id": "reaction_10633555", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10601623": { "compartment": "compartment_70101", "id": "reaction_10601623", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10599804": { "compartment": "compartment_5460", "id": "reaction_10599804", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10603975": { "compartment": "compartment_5460", "id": "reaction_10603975", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77330", "species_113526" ], "products": [ "species_77328", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10602168": { "compartment": "compartment_70101", "id": "reaction_10602168", "reactome": "R-CEL-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10602165", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10614865": { "compartment": "compartment_70101", "id": "reaction_10614865", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10633254": { "compartment": "compartment_171062", "id": "reaction_10633254", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10633615": { "compartment": "compartment_70101", "id": "reaction_10633615", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10633612", "catalyst" ] ], "additional_components": [ "G5ED01", "WBGene00012148", "species_29360" ] }, "reaction_10651384": { "compartment": "compartment_5460", "id": "reaction_10651384", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10599091", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10599083": { "compartment": "compartment_5460", "id": "reaction_10599083", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10613678": { "compartment": "compartment_70101", "id": "reaction_10613678", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10613675", "catalyst" ] ], "additional_components": [ "P90986", "WBGene00000296", "species_113531" ] }, "reaction_10649079": { "compartment": "compartment_5460", "id": "reaction_10649079", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649066", "species_113526" ], "products": [ "species_29362", "species_113529", "species_10649049" ], "modifiers": [ [ "species_10649076", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10656390": { "compartment": "compartment_70101", "id": "reaction_10656390", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656386", "species_10633085" ], "products": [ "species_10656388" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10649087": { "compartment": "compartment_12045", "id": "reaction_10649087", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694080", "species_29356" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10649084", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10617777": { "compartment": "compartment_17951", "id": "reaction_10617777", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10617774", "catalyst" ] ], "additional_components": [ "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10643266": { "compartment": "compartment_70101", "id": "reaction_10643266", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_202124", "species_10643261" ], "products": [ "species_29366", "species_432031", "species_10643259" ], "modifiers": [ [ "species_10643261", "catalyst" ] ], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10611257": { "compartment": "compartment_70101", "id": "reaction_10611257", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10603987": { "compartment": "compartment_5460", "id": "reaction_10603987", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77337", "species_113596" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604559": { "compartment": "compartment_70101", "id": "reaction_10604559", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "Q09629", "WBGene00014058" ] }, "reaction_10613762": { "compartment": "compartment_984", "id": "reaction_10613762", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10643233": { "compartment": "compartment_70101", "id": "reaction_10643233", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10643230", "catalyst" ] ], "additional_components": [ "A0A3P6NP42", "WBGene00018632", "Q21333", "WBGene00010666" ] }, "reaction_10657675": { "compartment": "compartment_984", "id": "reaction_10657675", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851462", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851461" ], "modifiers": [ [ "species_10657672", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58280", "CHEBI:58069", "species_205687", "species_727810", "species_29602", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10665627": { "compartment": "compartment_70101", "id": "reaction_10665627", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10632920": { "compartment": "compartment_876", "id": "reaction_10632920", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632917", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10656848": { "compartment": "compartment_876", "id": "reaction_10656848", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10656845", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10660188": { "compartment": "compartment_70101", "id": "reaction_10660188", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10660185", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10599086": { "compartment": "compartment_5460", "id": "reaction_10599086", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10625272": { "compartment": "compartment_70101", "id": "reaction_10625272", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10648833": { "compartment": "compartment_70101", "id": "reaction_10648833", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10648830", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10602145": { "compartment": "compartment_70101", "id": "reaction_10602145", "reactome": "R-CEL-74213", "name": "APRT catalyzes the conversion of adenine to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10602142", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10615271": { "compartment": "compartment_70101", "id": "reaction_10615271", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10615268", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10636569": { "compartment": "compartment_5460", "id": "reaction_10636569", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636565", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10636563" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_113596", "Q9U1X0", "WBGene00013376", "species_31649" ] }, "reaction_10634926": { "compartment": "compartment_70101", "id": "reaction_10634926", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023974", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10613746": { "compartment": "compartment_876", "id": "reaction_10613746", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10601727": { "compartment": "compartment_7660", "id": "reaction_10601727", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10601724", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10636096": { "compartment": "compartment_70101", "id": "reaction_10636096", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_2142716", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10650343": { "compartment": "compartment_70101", "id": "reaction_10650343", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10650340", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150", "species_109496" ] }, "reaction_10632912": { "compartment": "compartment_876", "id": "reaction_10632912", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429807" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10632909", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10630220": { "compartment": "compartment_5460", "id": "reaction_10630220", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630218", "species_113531" ], "products": [ "species_10630201" ], "modifiers": [], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10632619": { "compartment": "compartment_161320", "id": "reaction_10632619", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10632616", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10623707": { "compartment": "compartment_70101", "id": "reaction_10623707", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10623704", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10638225": { "compartment": "compartment_5460", "id": "reaction_10638225", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10638222", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10620552": { "compartment": "compartment_876", "id": "reaction_10620552", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10620549", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q20735", "WBGene00004893", "Q9TYV2", "WBGene00021075", "Q965Q4", "WBGene00004894" ] }, "reaction_10599065": { "compartment": "compartment_70101", "id": "reaction_10599065", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10599062", "catalyst" ] ], "additional_components": [ "Q9NAE2", "WBGene00013103", "species_29360" ] }, "reaction_10613764": { "compartment": "compartment_984", "id": "reaction_10613764", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10656409": { "compartment": "compartment_70101", "id": "reaction_10656409", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10614996": { "compartment": "compartment_984", "id": "reaction_10614996", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10633833": { "compartment": "compartment_876", "id": "reaction_10633833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10633830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10603957": { "compartment": "compartment_5460", "id": "reaction_10603957", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77300", "species_113526" ], "products": [ "species_77302", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10630813": { "compartment": "compartment_876", "id": "reaction_10630813", "reactome": "R-CEL-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10656977": { "compartment": "compartment_12045", "id": "reaction_10656977", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6814253", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10656974", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10648910": { "compartment": "compartment_876", "id": "reaction_10648910", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351626", "species_352327" ], "products": [ "species_351629", "species_351628" ], "modifiers": [ [ "species_10648907", "catalyst" ] ], "additional_components": [ "WBGene00000253" ] }, "reaction_10598764": { "compartment": "compartment_70101", "id": "reaction_10598764", "reactome": "R-CEL-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10598761", "catalyst" ] ], "additional_components": [ "O16924", "WBGene00003816" ] }, "reaction_10632599": { "compartment": "compartment_161320", "id": "reaction_10632599", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10650163": { "compartment": "compartment_70101", "id": "reaction_10650163", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29452" ], "products": [ "species_110096", "species_6785915" ], "modifiers": [ [ "species_10650160", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10604827": { "compartment": "compartment_70101", "id": "reaction_10604827", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10643238": { "compartment": "compartment_70101", "id": "reaction_10643238", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643235", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10643204": { "compartment": "compartment_70101", "id": "reaction_10643204", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643195", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10642609": { "compartment": "compartment_70101", "id": "reaction_10642609", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642600" ], "products": [ "species_10642607" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10642621": { "compartment": "compartment_70101", "id": "reaction_10642621", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642617" ], "products": [ "species_10642619" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10643246": { "compartment": "compartment_70101", "id": "reaction_10643246", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10643243", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10660687": { "compartment": "compartment_70101", "id": "reaction_10660687", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10660684", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29612", "species_29444", "species_29468", "WBGene00021546" ] }, "reaction_10643218": { "compartment": "compartment_70101", "id": "reaction_10643218", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643215", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10606449": { "compartment": "compartment_7660", "id": "reaction_10606449", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10606444" ], "products": [ "species_113582", "species_10606447" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10617413": { "compartment": "compartment_70616", "id": "reaction_10617413", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10617410", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281", "O17895", "WBGene00001813" ] }, "reaction_10647412": { "compartment": "compartment_70101", "id": "reaction_10647412", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_352022", "species_29356" ], "products": [ "species_29370", "species_188972", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10630680": { "compartment": "compartment_70101", "id": "reaction_10630680", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10630677", "catalyst" ] ], "additional_components": [ "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411", "Q9XW61", "WBGene00003414", "Q95QV2", "WBGene00000477", "Q19048", "WBGene00003409" ] }, "reaction_10658922": { "compartment": "compartment_70101", "id": "reaction_10658922", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658885" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10630270": { "compartment": "compartment_17906", "id": "reaction_10630270", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_113592", "species_29356" ], "products": [ "species_1369027", "species_29370", "species_29372" ], "modifiers": [ [ "species_10630267", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10658934": { "compartment": "compartment_876", "id": "reaction_10658934", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883" ], "products": [ "species_10617481" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10642580": { "compartment": "compartment_70101", "id": "reaction_10642580", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5223341", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_5223344" ], "modifiers": [ [ "species_10642577", "catalyst" ] ], "additional_components": [ "O44897", "WBGene00001819" ] }, "reaction_10642630": { "compartment": "compartment_70101", "id": "reaction_10642630", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642626", "species_10601197" ], "products": [ "species_10642628" ], "modifiers": [], "additional_components": [ "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19554", "WBGene00006512", "Q21230", "WBGene00010560" ] }, "reaction_10617438": { "compartment": "compartment_17947", "id": "reaction_10617438", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10617435", "catalyst" ] ], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061" ] }, "reaction_10617484": { "compartment": "compartment_876", "id": "reaction_10617484", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_29356" ], "products": [ "species_29370", "species_425425", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10658920": { "compartment": "compartment_12045", "id": "reaction_10658920", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883", "species_10658909" ], "products": [ "species_10658915" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10617469": { "compartment": "compartment_17947", "id": "reaction_10617469", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617467", "species_10617443" ], "products": [ "species_10617435", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "P34453", "WBGene00004201", "WBGene00004193", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "WBGene00004193", "WBGene00004201" ] }, "reaction_10658918": { "compartment": "compartment_12045", "id": "reaction_10658918", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658915", "species_10597908" ], "products": [ "species_10658911" ], "modifiers": [ [ "species_10658915", "catalyst" ] ], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10658913": { "compartment": "compartment_12045", "id": "reaction_10658913", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658911", "species_29356" ], "products": [ "species_29370", "species_10658885", "species_29372", "species_10658909" ], "modifiers": [], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10647530": { "compartment": "compartment_70101", "id": "reaction_10647530", "reactome": "R-CEL-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10647527", "catalyst" ] ], "additional_components": [ "Q9TXV8", "WBGene00000022", "Q9XW49", "WBGene00000023", "Q1RS86", "WBGene00000020", "P34358", "WBGene00000421" ] }, "reaction_10615447": { "compartment": "compartment_70101", "id": "reaction_10615447", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440" ], "products": [ "species_10615444", "species_10615442" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10625999": { "compartment": "compartment_20699", "id": "reaction_10625999", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_113592", "species_29356" ], "products": [ "species_29370", "species_167012", "species_29372" ], "modifiers": [ [ "species_10625996", "catalyst" ] ], "additional_components": [ "G5EDU1", "WBGene00004063", "species_109496" ] }, "reaction_10638045": { "compartment": "compartment_17927", "id": "reaction_10638045", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889081", "species_113529" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10638042", "catalyst" ] ], "additional_components": [ "species_74113", "species_425815", "species_74113", "species_425815", "WBGene00009617" ] }, "reaction_10619535": { "compartment": "compartment_171062", "id": "reaction_10619535", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10619530", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10622391": { "compartment": "compartment_70101", "id": "reaction_10622391", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637543": { "compartment": "compartment_70101", "id": "reaction_10637543", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637540", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10626047": { "compartment": "compartment_876", "id": "reaction_10626047", "reactome": "R-CEL-937311", "name": "ATP12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10626044", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10656840": { "compartment": "compartment_70101", "id": "reaction_10656840", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10656837", "catalyst" ] ], "additional_components": [ "Q7JMM5", "WBGene00017515", "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q94187", "WBGene00017515" ] }, "reaction_10638040": { "compartment": "compartment_984", "id": "reaction_10638040", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10638037", "catalyst" ] ], "additional_components": [ "Q9XU88", "WBGene00010214", "Q20273", "WBGene00009617", "G5EFS0", "WBGene00009618" ] }, "reaction_10620374": { "compartment": "compartment_876", "id": "reaction_10620374", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10620371", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10629117": { "compartment": "compartment_984", "id": "reaction_10629117", "reactome": "R-CEL-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10615975": { "compartment": "compartment_876", "id": "reaction_10615975", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_113538", "species_159549", "WBGene00012804" ] }, "reaction_10637530": { "compartment": "compartment_70101", "id": "reaction_10637530", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637458", "species_113592", "species_10597908" ], "products": [ "species_29370", "species_10637478", "species_947590" ], "modifiers": [ [ "species_10637516", "catalyst" ], [ "species_10637522", "catalyst" ] ], "additional_components": [ "Q19777", "WBGene00009109", "WBGene00006727", "Q19777", "WBGene00009109", "G4S4W1", "WBGene00016980", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "Q07292", "WBGene00003030", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "WBGene00006941" ] }, "reaction_10626107": { "compartment": "compartment_876", "id": "reaction_10626107", "reactome": "R-CEL-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947594", "species_113592", "species_29356" ], "products": [ "species_29370", "species_947588", "species_29372" ], "modifiers": [ [ "species_10626104", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1524083", "species_1500646", "species_1524083", "P91203", "WBGene00017174", "Q9U280", "WBGene00013034", "O18182", "WBGene00012360", "U4PBV8", "WBGene00019166", "Q7JPE3", "WBGene00020784", "G5EBH1", "WBGene00009498" ] }, "reaction_10615157": { "compartment": "compartment_876", "id": "reaction_10615157", "reactome": "R-CEL-352364", "name": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352036", "species_74113" ], "products": [ "species_83910", "species_352359", "species_74113", "species_29432" ], "modifiers": [ [ "species_10615150", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_352002", "species_351990", "species_29432", "species_111707", "species_352002", "species_351990", "WBGene00001622" ] }, "reaction_10637617": { "compartment": "compartment_70101", "id": "reaction_10637617", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2730999" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10637614", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10659515": { "compartment": "compartment_876", "id": "reaction_10659515", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10625831": { "compartment": "compartment_947586", "id": "reaction_10625831", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10642981": { "compartment": "compartment_70101", "id": "reaction_10642981", "reactome": "R-CEL-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10642978", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10643209": { "compartment": "compartment_70101", "id": "reaction_10643209", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622382", "catalyst" ], [ "species_10643207", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q20734", "WBGene00043980", "WBGene00002881" ] }, "reaction_10662986": { "compartment": "compartment_70101", "id": "reaction_10662986", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662983", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10619506": { "compartment": "compartment_876", "id": "reaction_10619506", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112", "species_74126" ], "modifiers": [ [ "species_10619503", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10663007": { "compartment": "compartment_70101", "id": "reaction_10663007", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10663004", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10620458": { "compartment": "compartment_876", "id": "reaction_10620458", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10616007": { "compartment": "compartment_876", "id": "reaction_10616007", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10616004", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_29432", "species_113538", "species_159549", "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10620122": { "compartment": "compartment_201753", "id": "reaction_10620122", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10620119", "catalyst" ] ], "additional_components": [ "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556" ] }, "reaction_10620250": { "compartment": "compartment_201753", "id": "reaction_10620250", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_428592" ], "products": [ "species_70106", "species_428632" ], "modifiers": [ [ "species_10620247", "catalyst" ] ], "additional_components": [ "species_352003", "species_159549", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10637656": { "compartment": "compartment_70101", "id": "reaction_10637656", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637653", "catalyst" ] ], "additional_components": [ "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528", "G5EG93", "WBGene00000529", "Q9BMK9", "WBGene00000530" ] }, "reaction_10639280": { "compartment": "compartment_70101", "id": "reaction_10639280", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639277", "catalyst" ] ], "additional_components": [ "P34586", "WBGene00006614", "G5EDR9", "WBGene00003838", "Q22374", "WBGene00003840", "Q8T666", "WBGene00000846", "O61220", "WBGene00003839", "Q20766", "WBGene00001796", "P34641", "WBGene00000425", "Q8I6Y9", "WBGene00006615", "G5EF09", "WBGene00004976", "Q23141", "WBGene00020972", "Q9N3Y9", "WBGene00003841", "G5ECM4", "WBGene00001795", "Q93971", "WBGene00001651", "Q19377", "WBGene00008731" ] }, "reaction_10620097": { "compartment": "compartment_876", "id": "reaction_10620097", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10620094", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "WBGene00003876" ] }, "reaction_10663009": { "compartment": "compartment_70101", "id": "reaction_10663009", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637671": { "compartment": "compartment_70101", "id": "reaction_10637671", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637668", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10648663": { "compartment": "compartment_70101", "id": "reaction_10648663", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10648656", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10665480": { "compartment": "compartment_876", "id": "reaction_10665480", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665478", "species_351626" ], "products": [ "species_10637417" ], "modifiers": [], "additional_components": [ "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "Q10025", "WBGene00020897", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465" ] }, "reaction_10658135": { "compartment": "compartment_876", "id": "reaction_10658135", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658125" ], "products": [ "species_10658133" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10619627": { "compartment": "compartment_876", "id": "reaction_10619627", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10619624", "catalyst" ] ], "additional_components": [ "G5EBK1", "WBGene00003943", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10637666": { "compartment": "compartment_70101", "id": "reaction_10637666", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637661", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10637927": { "compartment": "compartment_70101", "id": "reaction_10637927", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10637915", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10658393": { "compartment": "compartment_876", "id": "reaction_10658393", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658389", "species_10637417" ], "products": [ "species_10658391" ], "modifiers": [], "additional_components": [ "Q7YZV6", "WBGene00006067", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "Q7YZV6", "WBGene00006067", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064" ] }, "reaction_10607855": { "compartment": "compartment_74700", "id": "reaction_10607855", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607851" ], "products": [ "species_10607853" ], "modifiers": [], "additional_components": [ "WBGene00020481", "WBGene00020481" ] }, "reaction_10637985": { "compartment": "compartment_70101", "id": "reaction_10637985", "reactome": "R-CEL-2855020", "name": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2855229" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10637970", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_74016", "catalyst" ], [ "species_10637983", "inhibitor" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "Q20203", "WBGene00000822", "A8WHT8", "WBGene00010703", "A0A2C9C3E8", "WBGene00006801", "Q9U2Q8", "WBGene00001427", "O45405", "WBGene00001371", "Q8WQA4", "WBGene00001365", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10619715": { "compartment": "compartment_876", "id": "reaction_10619715", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_188972", "species_74126" ], "modifiers": [ [ "species_10619712", "catalyst" ] ], "additional_components": [ "Q09573", "WBGene00019289", "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205" ] }, "reaction_10660137": { "compartment": "compartment_12045", "id": "reaction_10660137", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660133" ], "products": [ "species_193384", "species_10660131" ], "modifiers": [], "additional_components": [ "species_8848047", "P34389", "WBGene00003562", "WBGene00003562" ] }, "reaction_10637444": { "compartment": "compartment_70101", "id": "reaction_10637444", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637417", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_10637442", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066" ] }, "reaction_10660129": { "compartment": "compartment_161320", "id": "reaction_10660129", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10660125" ], "products": [ "species_10660127" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_8848047", "O17271", "WBGene00006452" ] }, "reaction_10620016": { "compartment": "compartment_876", "id": "reaction_10620016", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620013", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10662860": { "compartment": "compartment_70101", "id": "reaction_10662860", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10662857", "catalyst" ] ], "additional_components": [ "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10620008": { "compartment": "compartment_876", "id": "reaction_10620008", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620005", "catalyst" ] ], "additional_components": [ "O17404", "WBGene00017312", "O45220", "WBGene00007141", "Q17454", "WBGene00015054", "P91840", "WBGene00012285", "Q17455", "WBGene00015055", "Q18697", "WBGene00016739" ] }, "reaction_10660180": { "compartment": "compartment_12045", "id": "reaction_10660180", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_76194", "species_8876704" ], "modifiers": [ [ "species_10660175", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10625823": { "compartment": "compartment_984", "id": "reaction_10625823", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_912516", "species_917828" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625820", "catalyst" ] ], "additional_components": [ "P34465", "WBGene00018210", "O16271", "WBGene00018210", "species_71185", "O16272", "WBGene00018210" ] }, "reaction_10615166": { "compartment": "compartment_876", "id": "reaction_10615166", "reactome": "R-CEL-352385", "name": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_83910", "species_74113", "species_29432" ], "products": [ "species_29472", "species_83910", "species_352036", "species_74113" ], "modifiers": [ [ "species_10615161", "catalyst" ] ], "additional_components": [ "WBGene00001622" ] }, "reaction_10626007": { "compartment": "compartment_20699", "id": "reaction_10626007", "reactome": "R-CEL-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10626004", "catalyst" ] ], "additional_components": [ "WBGene00000834" ] }, "reaction_10648767": { "compartment": "compartment_70101", "id": "reaction_10648767", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10648660" ], "products": [ "species_10648758" ], "modifiers": [ [ "species_10648764", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807" ] }, "reaction_10648852": { "compartment": "compartment_70101", "id": "reaction_10648852", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10648849", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10620426": { "compartment": "compartment_876", "id": "reaction_10620426", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10620423", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10666181": { "compartment": "compartment_876", "id": "reaction_10666181", "reactome": "R-CEL-9727198", "name": "ATP4A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10666178", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10631304": { "compartment": "compartment_70101", "id": "reaction_10631304", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_71067" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10621144", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10619675": { "compartment": "compartment_876", "id": "reaction_10619675", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10619672", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10665971": { "compartment": "compartment_70101", "id": "reaction_10665971", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639225", "catalyst" ] ], "additional_components": [ "G5EDR9", "WBGene00003838", "Q9N3Y9", "WBGene00003841", "Q22374", "WBGene00003840", "O61220", "WBGene00003839" ] }, "reaction_10625842": { "compartment": "compartment_947586", "id": "reaction_10625842", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10619528": { "compartment": "compartment_172574", "id": "reaction_10619528", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_425999" ], "products": [ "species_70106", "species_425977" ], "modifiers": [ [ "species_10619525", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10619514": { "compartment": "compartment_876", "id": "reaction_10619514", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_425815" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10619511", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10662981": { "compartment": "compartment_70101", "id": "reaction_10662981", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662978", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10619639": { "compartment": "compartment_20699", "id": "reaction_10619639", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10619636", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10619666": { "compartment": "compartment_876", "id": "reaction_10619666", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_74126" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10619663", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10637918": { "compartment": "compartment_70101", "id": "reaction_10637918", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637915", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10650003": { "compartment": "compartment_1660541", "id": "reaction_10650003", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649973" ], "products": [ "species_10650001" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10650005": { "compartment": "compartment_1660541", "id": "reaction_10650005", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650001" ], "products": [ "species_10649999" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10620099": { "compartment": "compartment_876", "id": "reaction_10620099", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_428027", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_427997", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ] ], "additional_components": [ "species_6810061", "species_427963", "species_113552", "species_6810061", "species_427963", "species_113552", "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10630870": { "compartment": "compartment_70101", "id": "reaction_10630870", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10622388": { "compartment": "compartment_70101", "id": "reaction_10622388", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622384" ], "products": [ "species_10622382", "species_113592" ], "modifiers": [], "additional_components": [ "species_113592", "Q20734", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10660135": { "compartment": "compartment_161320", "id": "reaction_10660135", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660127", "species_10660131" ], "products": [ "species_10660133", "species_10660125" ], "modifiers": [], "additional_components": [ "species_8848047", "O17271", "WBGene00006452", "WBGene00003562", "species_8848047", "P34389", "WBGene00003562", "WBGene00006452" ] }, "reaction_10648755": { "compartment": "compartment_5460", "id": "reaction_10648755", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10648752", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10620088": { "compartment": "compartment_12045", "id": "reaction_10620088", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_156540" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10620064", "catalyst" ], [ "species_10620086", "catalyst" ] ], "additional_components": [ "WBGene00004736", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10620519": { "compartment": "compartment_876", "id": "reaction_10620519", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10648841": { "compartment": "compartment_70101", "id": "reaction_10648841", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10648838", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10658121": { "compartment": "compartment_70101", "id": "reaction_10658121", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_71285", "species_2162265" ], "modifiers": [ [ "species_10658118", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10660027": { "compartment": "compartment_70101", "id": "reaction_10660027", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10660024", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10648776": { "compartment": "compartment_70101", "id": "reaction_10648776", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613629", "species_10648772" ], "products": [ "species_10648774" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10622386": { "compartment": "compartment_70101", "id": "reaction_10622386", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622382", "species_113592" ], "products": [ "species_10622384" ], "modifiers": [], "additional_components": [ "Q20734", "WBGene00043980", "species_113592", "Q20734", "WBGene00043980" ] }, "reaction_10637553": { "compartment": "compartment_70101", "id": "reaction_10637553", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10637548", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10648658": { "compartment": "compartment_70101", "id": "reaction_10648658", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648654", "species_5690881" ], "products": [ "species_10648656" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10607567": { "compartment": "compartment_70101", "id": "reaction_10607567", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607560" ], "products": [ "species_29370", "species_10607562" ], "modifiers": [ [ "species_10607564", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00006940" ] }, "reaction_10607608": { "compartment": "compartment_13231", "id": "reaction_10607608", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607606" ], "products": [ "species_10607600" ], "modifiers": [], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10638343": { "compartment": "compartment_70101", "id": "reaction_10638343", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605884" ], "products": [ "species_10605870" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10638290": { "compartment": "compartment_70101", "id": "reaction_10638290", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10638283" ], "products": [ "species_10638287", "species_29370", "species_10605884" ], "modifiers": [ [ "species_10638283", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198", "WBGene00010198", "WBGene00004043", "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198" ] }, "reaction_10607552": { "compartment": "compartment_13231", "id": "reaction_10607552", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607520" ], "products": [ "species_10607550" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10638363": { "compartment": "compartment_7660", "id": "reaction_10638363", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10605870" ], "products": [ "species_10638345", "species_113550" ], "modifiers": [ [ "species_10638360", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10607604": { "compartment": "compartment_7660", "id": "reaction_10607604", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607600", "species_29358" ], "products": [ "species_113582", "species_10607602" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10607584": { "compartment": "compartment_7660", "id": "reaction_10607584", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607532" ], "products": [ "species_113582", "species_10607573" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10658258": { "compartment": "compartment_7660", "id": "reaction_10658258", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630226", "species_77087" ], "products": [ "species_10658250", "species_77502" ], "modifiers": [ [ "species_10658255", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007137" ] }, "reaction_10658266": { "compartment": "compartment_7660", "id": "reaction_10658266", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658250", "species_113518" ], "products": [ "species_8857797", "species_10630226" ], "modifiers": [ [ "species_10658263", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007188" ] }, "reaction_10607569": { "compartment": "compartment_70101", "id": "reaction_10607569", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607556" ], "products": [ "species_10607560" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657946": { "compartment": "compartment_70101", "id": "reaction_10657946", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657941" ], "products": [ "species_10657884", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607598": { "compartment": "compartment_70101", "id": "reaction_10607598", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607594" ], "products": [ "species_10607596" ], "modifiers": [], "additional_components": [ "WBGene00000405", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10607580": { "compartment": "compartment_13231", "id": "reaction_10607580", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607536" ], "products": [ "species_10607496" ], "modifiers": [ [ "species_10607578", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10657944": { "compartment": "compartment_70101", "id": "reaction_10657944", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657898", "species_10597908" ], "products": [ "species_10657941" ], "modifiers": [ [ "species_10657898", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320", "WBGene00006727", "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10640968": { "compartment": "compartment_70101", "id": "reaction_10640968", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640966" ], "products": [ "species_29370", "species_10638281" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10607619": { "compartment": "compartment_13231", "id": "reaction_10607619", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607518" ], "products": [ "species_10607548" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657900": { "compartment": "compartment_70101", "id": "reaction_10657900", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657896", "species_10657884" ], "products": [ "species_10657898" ], "modifiers": [], "additional_components": [ "O01427", "WBGene00000099", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10607617": { "compartment": "compartment_70101", "id": "reaction_10607617", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607610" ], "products": [ "species_29370", "species_10607518" ], "modifiers": [ [ "species_10607614", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N2L7", "WBGene00004043", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10658008": { "compartment": "compartment_171062", "id": "reaction_10658008", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658004", "species_10657982" ], "products": [ "species_10658006" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644", "WBGene00012894", "P91857", "WBGene00004268", "Q9U2D8", "WBGene00012894", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644" ] }, "reaction_10658113": { "compartment": "compartment_262783", "id": "reaction_10658113", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658104", "species_10658109", "species_10658098" ], "products": [ "species_10658111" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "WBGene00044061", "WBGene00004274", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061", "O01803", "WBGene00004274" ] }, "reaction_10658051": { "compartment": "compartment_17938", "id": "reaction_10658051", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658049", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_111349", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271" ] }, "reaction_10658022": { "compartment": "compartment_17938", "id": "reaction_10658022", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658014", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ], [ "species_10658020", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271", "WBGene00022880" ] }, "reaction_10658045": { "compartment": "compartment_20699", "id": "reaction_10658045", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658041", "species_10657417" ], "products": [ "species_10658043" ], "modifiers": [], "additional_components": [ "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "H2KZZ6", "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10657976": { "compartment": "compartment_24339", "id": "reaction_10657976", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657953", "species_29356" ], "products": [ "species_29372", "species_10657955" ], "modifiers": [ [ "species_10657953", "catalyst" ], [ "species_10657974", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "species_29420", "Q9U2C3", "WBGene00004284", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "O44873", "WBGene00019915", "H2KZ54", "WBGene00016292" ] }, "reaction_10658036": { "compartment": "compartment_262783", "id": "reaction_10658036", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658025", "species_10658032" ], "products": [ "species_10658034" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "O44873", "WBGene00019915", "species_29438" ] }, "reaction_10646156": { "compartment": "compartment_7660", "id": "reaction_10646156", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646152", "species_10604720" ], "products": [ "species_10646154" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q19196", "WBGene00017237", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10620944": { "compartment": "compartment_70101", "id": "reaction_10620944", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10620938", "species_10608669", "species_10619297" ], "products": [ "species_10620942", "species_10614982", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "species_29438", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "species_29420", "G5EFK4", "WBGene00000183" ] }, "reaction_10646797": { "compartment": "compartment_20699", "id": "reaction_10646797", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646793", "species_10625671", "species_10608649" ], "products": [ "species_10646795" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q8WQB3", "WBGene00000158", "Q17796", "WBGene00004101" ] }, "reaction_10643083": { "compartment": "compartment_263163", "id": "reaction_10643083", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10643079" ], "products": [ "species_10643081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "P34574", "WBGene00011867", "species_5334668", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829" ] }, "reaction_10621011": { "compartment": "compartment_70101", "id": "reaction_10621011", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620942", "species_29438" ], "products": [ "species_10619299", "species_10608669", "species_29372", "species_29420", "species_10621008" ], "modifiers": [ [ "species_10620942", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q8WQB3", "WBGene00000158", "Q94057", "WBGene00044062", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "P51485", "WBGene00000195", "Q22616", "WBGene00011872", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898" ] }, "reaction_10612275": { "compartment": "compartment_70101", "id": "reaction_10612275", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612269" ], "products": [ "species_10612271", "species_10612273" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615087": { "compartment": "compartment_70101", "id": "reaction_10615087", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615078" ], "products": [ "species_10615082", "species_10615080" ], "modifiers": [ [ "species_10615084", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615118": { "compartment": "compartment_7660", "id": "reaction_10615118", "reactome": "R-CEL-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608315" ], "products": [ "species_10615095", "species_10615093" ], "modifiers": [ [ "species_10615115", "catalyst" ] ], "additional_components": [ "WBGene00009127", "WBGene00009127", "WBGene00009127", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611885": { "compartment": "compartment_70101", "id": "reaction_10611885", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611879" ], "products": [ "species_10611883", "species_10611881" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10611934": { "compartment": "compartment_70101", "id": "reaction_10611934", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611928" ], "products": [ "species_10611932", "species_10611930" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10612313": { "compartment": "compartment_70101", "id": "reaction_10612313", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612307" ], "products": [ "species_10612311", "species_10612309" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10612283": { "compartment": "compartment_70101", "id": "reaction_10612283", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612277" ], "products": [ "species_10612279", "species_10612281" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10614649": { "compartment": "compartment_7660", "id": "reaction_10614649", "reactome": "R-CEL-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614622" ], "products": [ "species_10614624", "species_10614626" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10664192": { "compartment": "compartment_13231", "id": "reaction_10664192", "reactome": "R-CEL-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664190" ], "products": [ "species_10614646" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611908": { "compartment": "compartment_70101", "id": "reaction_10611908", "reactome": "R-CEL-201634", "name": "Caspase-mediated cleavage of FADK 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901" ], "products": [ "species_10611903", "species_10611905" ], "modifiers": [ [ "species_10605385", "catalyst" ] ], "additional_components": [ "WBGene00002213", "WBGene00002213", "WBGene00002213", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611852": { "compartment": "compartment_70101", "id": "reaction_10611852", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846" ], "products": [ "species_10611848", "species_10611850" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10664170": { "compartment": "compartment_7660", "id": "reaction_10664170", "reactome": "R-CEL-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605385" ], "products": [ "species_10615115" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611844": { "compartment": "compartment_876", "id": "reaction_10611844", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611839" ], "products": [ "species_10611841" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10615122": { "compartment": "compartment_13231", "id": "reaction_10615122", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615080" ], "products": [ "species_10615120" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10614975": { "compartment": "compartment_70101", "id": "reaction_10614975", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614969" ], "products": [ "species_10614973", "species_10614971" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10611896": { "compartment": "compartment_70101", "id": "reaction_10611896", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611890" ], "products": [ "species_10611894", "species_10611892" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10611917": { "compartment": "compartment_70101", "id": "reaction_10611917", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611913" ], "products": [ "species_10611915" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10615065": { "compartment": "compartment_876", "id": "reaction_10615065", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615061" ], "products": [ "species_10615063" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615059": { "compartment": "compartment_70101", "id": "reaction_10615059", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615053" ], "products": [ "species_10615057", "species_10615055" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10615091": { "compartment": "compartment_876", "id": "reaction_10615091", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615089" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10614657": { "compartment": "compartment_7660", "id": "reaction_10614657", "reactome": "R-CEL-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614651" ], "products": [ "species_10614653", "species_10614655" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615131": { "compartment": "compartment_70101", "id": "reaction_10615131", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615127" ], "products": [ "species_10615129" ], "modifiers": [ [ "species_10615072", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10614404": { "compartment": "compartment_70101", "id": "reaction_10614404", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604948" ], "products": [ "species_10614400", "species_10614402" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10615051": { "compartment": "compartment_876", "id": "reaction_10615051", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615047" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10609819": { "compartment": "compartment_876", "id": "reaction_10609819", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_188995", "species_70113", "species_29532", "species_188995", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10609777": { "compartment": "compartment_876", "id": "reaction_10609777", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10609774", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10604700": { "compartment": "compartment_7660", "id": "reaction_10604700", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604690", "species_30555" ], "products": [ "species_10604697", "species_113541" ], "modifiers": [ [ "species_10604690", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604684": { "compartment": "compartment_7660", "id": "reaction_10604684", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604676", "species_10604680" ], "products": [ "species_10604682" ], "modifiers": [], "additional_components": [ "WBGene00018721", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604693": { "compartment": "compartment_7660", "id": "reaction_10604693", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604682", "species_29604" ], "products": [ "species_10604690", "species_113541" ], "modifiers": [ [ "species_10604682", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646366": { "compartment": "compartment_7660", "id": "reaction_10646366", "reactome": "R-CEL-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350" ], "products": [ "species_10646361", "species_10646363", "species_10646348" ], "modifiers": [ [ "species_10646350", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "WBGene00011216", "WBGene00011216", "WBGene00009441", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10646089": { "compartment": "compartment_7660", "id": "reaction_10646089", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646066", "species_10646085" ], "products": [ "species_10646087" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10646359": { "compartment": "compartment_7660", "id": "reaction_10646359", "reactome": "R-CEL-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350", "species_10646091" ], "products": [ "species_10646352" ], "modifiers": [], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646338": { "compartment": "compartment_7660", "id": "reaction_10646338", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646329", "species_29358" ], "products": [ "species_113582", "species_10646335", "species_10604676" ], "modifiers": [ [ "species_10646329", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00018721", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646331": { "compartment": "compartment_7660", "id": "reaction_10646331", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646327", "species_10646311" ], "products": [ "species_10646329" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646333": { "compartment": "compartment_7660", "id": "reaction_10646333", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604697", "species_10646309" ], "products": [ "species_10646311" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00011834", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646357": { "compartment": "compartment_7660", "id": "reaction_10646357", "reactome": "R-CEL-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646352" ], "products": [ "species_10646350", "species_10646354", "species_10597874" ], "modifiers": [ [ "species_10646352", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646094": { "compartment": "compartment_7660", "id": "reaction_10646094", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646087", "species_10597874" ], "products": [ "species_10646091", "species_10646085", "species_10604720" ], "modifiers": [ [ "species_10646087", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648209": { "compartment": "compartment_7660", "id": "reaction_10648209", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648199" ], "products": [ "species_68454", "species_10648206", "species_10598267" ], "modifiers": [ [ "species_10648199", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296" ] }, "reaction_10648197": { "compartment": "compartment_7660", "id": "reaction_10648197", "reactome": "R-CEL-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10648186" ], "products": [ "species_10648194", "species_113541" ], "modifiers": [ [ "species_10648186", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648188": { "compartment": "compartment_7660", "id": "reaction_10648188", "reactome": "R-CEL-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10648170", "species_10648180", "species_10598267" ], "products": [ "species_10648186" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "A0FLQ6", "WBGene00020964", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648202": { "compartment": "compartment_7660", "id": "reaction_10648202", "reactome": "R-CEL-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648194", "species_427523" ], "products": [ "species_10646052", "species_427497", "species_10648180", "species_10648199" ], "modifiers": [ [ "species_10648194", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "A0FLQ6", "WBGene00020964", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648173": { "compartment": "compartment_7660", "id": "reaction_10648173", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648166" ], "products": [ "species_30555", "species_10648170" ], "modifiers": [ [ "species_10648166", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10621613": { "compartment": "compartment_876", "id": "reaction_10621613", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_114523" ], "products": [ "species_83910", "species_352022", "species_209914" ], "modifiers": [ [ "species_10621610", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10617035": { "compartment": "compartment_5460", "id": "reaction_10617035", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10619309": { "compartment": "compartment_20699", "id": "reaction_10619309", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10619291", "species_10608669", "species_10619297" ], "products": [ "species_10614982", "species_10619307", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "species_29438", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10619432": { "compartment": "compartment_70101", "id": "reaction_10619432", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10619307" ], "products": [ "species_10619299", "species_10619429", "species_10608669", "species_29372", "species_29420" ], "modifiers": [ [ "species_10619307", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00001130", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9N489", "WBGene00022453", "Q9XZI6", "WBGene00006751", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "Q02328", "WBGene00022717", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10614994": { "compartment": "compartment_70101", "id": "reaction_10614994", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10614982" ], "products": [ "species_10614986", "species_29420" ], "modifiers": [ [ "species_10614991", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "species_29438", "G5EFK4", "WBGene00000183", "WBGene00007703" ] }, "reaction_10659242": { "compartment": "compartment_876", "id": "reaction_10659242", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659237", "species_29356" ], "products": [ "species_29372", "species_10659239" ], "modifiers": [ [ "species_10659237", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", 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has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10659118", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659177": { "compartment": "compartment_876", "id": "reaction_10659177", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659167", "species_10659171", "species_10608681", "species_10659141", "species_10659143", "species_10659124", "species_10659159", "species_10659118" ], "products": [ "species_10658206", "species_10633167", "species_10659175" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "Q6AHQ8", "WBGene00018467", "WBGene00003086", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "Q9TXS0", "WBGene00018974", "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898" ] }, "reaction_10659192": { "compartment": "compartment_876", "id": "reaction_10659192", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633167", "species_10659116" ], "products": [ "species_10659118" ], "modifiers": [], "additional_components": [ "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659179": { "compartment": "compartment_876", "id": "reaction_10659179", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10659114" ], "products": [ "species_10659116" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10658232": { "compartment": "compartment_876", "id": "reaction_10658232", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658218", "species_10658220", "species_10619297", "species_10658191", "species_10641905" ], "products": [ "species_10658224" ], "modifiers": [ [ "species_10658230", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "Q9BIF4", "WBGene00001224", "A0A0K3AS36", "Y116A8C.36d", "WBGene00022453", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10659190": { "compartment": "compartment_876", "id": "reaction_10659190", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10618288", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10658243": { "compartment": "compartment_876", "id": "reaction_10658243", "reactome": "R-CEL-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658224", "species_113592" ], "products": [ "species_29370", "species_10658240" ], "modifiers": [ [ "species_10658224", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10659244": { "compartment": "compartment_876", "id": "reaction_10659244", "reactome": "R-CEL-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633129", "species_10659225" ], "products": [ "species_10659237" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659409": { "compartment": "compartment_876", "id": "reaction_10659409", "reactome": "R-CEL-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10659239" ], "products": [ "species_10659402", "species_29372" ], "modifiers": [ [ "species_10659239", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", 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"WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "O76667", "WBGene00019183", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", 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"O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659815": { "compartment": "compartment_876", "id": "reaction_10659815", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619297", "species_10641905", "species_179856" ], "products": [ "species_10658214" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "species_179856" ] }, "reaction_10659813": { "compartment": "compartment_24339", "id": "reaction_10659813", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659811" ], "products": [ "species_10659460", "species_10658191" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "species_29420", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762" ] }, "reaction_10659221": { "compartment": "compartment_876", "id": "reaction_10659221", "reactome": "R-CEL-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659211", "species_10659207", "species_10659215", "species_10659175", "species_10659217", "species_10612328" ], "products": [ "species_10659219" ], "modifiers": [], "additional_components": [ "Q02328", "WBGene00022717", "species_113592", "P10984", "WBGene00000064", "Q02328", "WBGene00022717", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_113592", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "WBGene00007840", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659227": { "compartment": "compartment_876", "id": "reaction_10659227", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659223", "species_10659219" ], "products": [ "species_10659225" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10644197": { "compartment": "compartment_70101", "id": "reaction_10644197", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10644194", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10644705": { "compartment": "compartment_70101", "id": "reaction_10644705", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644685" ], "products": [ "species_29370", "species_10644703" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "WBGene00002189" ] }, "reaction_10619072": { "compartment": "compartment_204883", "id": "reaction_10619072", "reactome": "R-CEL-420598", "name": "Nectin-1:Nectin-4 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619068" ], "products": [ "species_10619070" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619066": { "compartment": "compartment_204883", "id": "reaction_10619066", "reactome": "R-CEL-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618975", "species_10611124" ], "products": [ "species_10619064" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619062": { "compartment": "compartment_204883", "id": "reaction_10619062", "reactome": "R-CEL-420580", "name": "Nectin-1:PVRL3 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619058" ], "products": [ "species_10619060" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10640549": { "compartment": "compartment_876", "id": "reaction_10640549", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612994", "species_10640545" ], "products": [ "species_10640547" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247" ] }, "reaction_10614501": { "compartment": "compartment_984", "id": "reaction_10614501", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614495", "species_10614497" ], "products": [ "species_10614499" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10640887": { "compartment": "compartment_984", "id": "reaction_10640887", "reactome": "R-CEL-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640883", "species_10631599" ], "products": [ "species_10640885" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "WBGene00006787", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q06561", "WBGene00006787", "Q21313", "WBGene00001328", "O44565", "WBGene00002247" ] }, "reaction_10614473": { "compartment": "compartment_984", "id": "reaction_10614473", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614469", "species_10614421" ], "products": [ "species_10614471" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10636750": { "compartment": "compartment_984", "id": "reaction_10636750", "reactome": "R-CEL-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_10636746" ], "products": [ "species_10636748" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "P17139", "WBGene00001263", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779" ] }, "reaction_10665322": { "compartment": "compartment_17938", "id": "reaction_10665322", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10665189" ], "products": [ "species_10665191" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665314": { "compartment": "compartment_17938", "id": "reaction_10665314", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606895", "species_10665178" ], "products": [ "species_10665189" ], "modifiers": [], "additional_components": [ "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665172": { "compartment": "compartment_17938", "id": "reaction_10665172", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165", "species_29420" ], "products": [ "species_29438", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665311": { "compartment": "compartment_17938", "id": "reaction_10665311", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165" ], "products": [ "species_29372", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ], [ "species_10665309", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "H2L0I8", "WBGene00020208", "S6FMZ4", "WBGene00017699" ] }, "reaction_10665185": { "compartment": "compartment_17938", "id": "reaction_10665185", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665180" ], "products": [ "species_10665178", "species_10665174" ], "modifiers": [], "additional_components": [ "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29468", "Q19425", "WBGene00008774" ] }, "reaction_10665187": { "compartment": "compartment_17938", "id": "reaction_10665187", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665174", "species_10665169" ], "products": [ "species_10665176" ], "modifiers": [], "additional_components": [ "species_29468", "Q19425", "WBGene00008774", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665183": { "compartment": "compartment_17938", "id": "reaction_10665183", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665176" ], "products": [ "species_10665180", "species_29420" ], "modifiers": [ [ "species_10665176", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665196": { "compartment": "compartment_17938", "id": "reaction_10665196", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665191" ], "products": [ "species_10665193", "species_29372" ], "modifiers": [ [ "species_10665191", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P91040", "WBGene00015697", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665769": { "compartment": "compartment_7660", "id": "reaction_10665769", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649795" ], "products": [ "species_113582", "species_10649806", "species_113550" ], "modifiers": [ [ "species_10649795", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649828": { "compartment": "compartment_7660", "id": "reaction_10649828", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10649814" ], "products": [ "species_10649826" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "Q18547", "WBGene00004339", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q23088", "WBGene00022812", "Q19366", "WBGene00008722", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "O62218", "WBGene00009368", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10649798": { "compartment": "compartment_7660", "id": "reaction_10649798", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649784" ], "products": [ "species_113582", "species_113550", "species_10649795" ], "modifiers": [ [ "species_10649784", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649812": { "compartment": "compartment_7660", "id": "reaction_10649812", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649808", "species_10604543" ], "products": [ "species_10649810" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649817": { "compartment": "compartment_7660", "id": "reaction_10649817", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649810" ], "products": [ "species_10649814" ], "modifiers": [ [ "species_10649810", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10618987": { "compartment": "compartment_204883", "id": "reaction_10618987", "reactome": "R-CEL-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983" ], "products": [ "species_10618985" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10621121": { "compartment": "compartment_876", "id": "reaction_10621121", "reactome": "R-CEL-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973" ], "products": [ "species_10618983" ], "modifiers": [], "additional_components": [ "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10618981": { "compartment": "compartment_70101", "id": "reaction_10618981", "reactome": "R-CEL-419003", "name": "Interaction of Nectins with Afadin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973", "species_10618971" ], "products": [ "species_10618979" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00021009", "Q86NJ4", "WBGene00021009", "G5EG33", "WBGene00001863" ] }, "reaction_10619084": { "compartment": "compartment_20699", "id": "reaction_10619084", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617173" ], "products": [ "species_10619076", "species_10617114" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10617118": { "compartment": "compartment_70101", "id": "reaction_10617118", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617114" ], "products": [ "species_10617116" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10617166": { "compartment": "compartment_70101", "id": "reaction_10617166", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601197" ], "products": [ "species_29370", "species_10617163" ], "modifiers": [ [ "species_10617139", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10617156": { "compartment": "compartment_12045", "id": "reaction_10617156", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617148" ], "products": [ "species_29370", "species_10617153" ], "modifiers": [ [ "species_10617148", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10617158": { "compartment": "compartment_12045", "id": "reaction_10617158", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617146" ], "products": [ "species_10617148" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10628857": { "compartment": "compartment_70101", "id": "reaction_10628857", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628845" ], "products": [ "species_10628851" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10628923": { "compartment": "compartment_7660", "id": "reaction_10628923", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628851", "species_10628892" ], "products": [ "species_10628894" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00000095", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639875": { "compartment": "compartment_70101", "id": "reaction_10639875", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639873", "species_10639871" ], "products": [ "species_10639772" ], "modifiers": [], "additional_components": [ "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O16303", "WBGene00001037", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030" ] }, "reaction_10617141": { "compartment": "compartment_12045", "id": "reaction_10617141", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130" ], "products": [ "species_10617139" ], "modifiers": [], "additional_components": [ "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10628905": { "compartment": "compartment_7660", "id": "reaction_10628905", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10628894", "species_10628901", "species_29428" ], "products": [ "species_10628903" ], "modifiers": [], "additional_components": [ "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639777": { "compartment": "compartment_70101", "id": "reaction_10639777", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639772" ], "products": [ "species_10639774", "species_29372" ], "modifiers": [ [ "species_10639772", "catalyst" ], [ "species_10639770", "catalyst" ] ], "additional_components": [ "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_29370", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "O45502", "WBGene00001030" ] }, "reaction_10617181": { "compartment": "compartment_12045", "id": "reaction_10617181", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617177" ], "products": [ "species_10617171" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10665100": { "compartment": "compartment_876", "id": "reaction_10665100", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615353", "species_9634838" ], "products": [ "species_10615363" ], "modifiers": [], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10615850": { "compartment": "compartment_984", "id": "reaction_10615850", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660314": { "compartment": "compartment_13946", "id": "reaction_10660314", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660280" ], "products": [ "species_10659955", "species_10660290", "species_29420" ], "modifiers": [ [ "species_10660311", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9UAQ6", "WBGene00004266", "Q9BKQ5", "WBGene00022051", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29438", "Q5WRR4", "WBGene00016614", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "Q95QQ2", "WBGene00016964", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "O02173", "WBGene00021046" ] }, "reaction_10659968": { "compartment": "compartment_216813", "id": "reaction_10659968", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10659957" ], "products": [ "species_10659955", "species_10659961", "species_29420" ], "modifiers": [ [ "species_10659965", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q94986", "WBGene00004267", "Q20759", "WBGene00010045", "O02626", "WBGene00000086" ] }, "reaction_10660750": { "compartment": "compartment_70101", "id": "reaction_10660750", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660324", "species_113592" ], "products": [ "species_29370", "species_10660745" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10660061": { "compartment": "compartment_437051", "id": "reaction_10660061", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660045" ], "products": [ "species_10660049", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660054", "catalyst" ] ], "additional_components": [ "species_29420", "Q94148", "WBGene00004273", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10660203": { "compartment": "compartment_171062", "id": "reaction_10660203", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660192" ], "products": [ "species_10660196", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660198", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q22045", "WBGene00004279", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10660096": { "compartment": "compartment_263163", "id": "reaction_10660096", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660085" ], "products": [ "species_10659955", "species_10660093", "species_29420" ], "modifiers": [ [ "species_10657253", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10660170": { "compartment": "compartment_70101", "id": "reaction_10660170", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660154" ], "products": [ "species_10660158", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660167", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29438", "Q93874", "WBGene00004276", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10660377": { "compartment": "compartment_20699", "id": "reaction_10660377", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660361" ], "products": [ "species_10660367", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660372", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29438", "Q18969", "WBGene00004286", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10660123": { "compartment": "compartment_262783", "id": "reaction_10660123", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660114" ], "products": [ "species_10659955", "species_10660118", "species_29420" ], "modifiers": [ [ "species_10660120", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "U4PBM1", "WBGene00018681" ] }, "reaction_10660329": { "compartment": "compartment_262783", "id": "reaction_10660329", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660318", "species_29438" ], "products": [ "species_10660322", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660324", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10660406": { "compartment": "compartment_12045", "id": "reaction_10660406", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660393" ], "products": [ "species_10660397", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660403", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q8MXS1", "WBGene00004277", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10660150": { "compartment": "compartment_204883", "id": "reaction_10660150", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660141" ], "products": [ "species_10659955", "species_29420", "species_10660145" ], "modifiers": [ [ "species_10660147", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375" ] }, "reaction_10660245": { "compartment": "compartment_5668575", "id": "reaction_10660245", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660232" ], "products": [ "species_10660242", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10645717", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29438", "G5EBS5", "WBGene00000089", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10660272": { "compartment": "compartment_17938", "id": "reaction_10660272", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660249" ], "products": [ "species_10659955", "species_10660255", "species_29420" ], "modifiers": [ [ "species_10660269", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q23146", "WBGene00004271", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q23146", "WBGene00004271", "Q9BI89", "WBGene00018321", "Q9XVL8", "WBGene00010283" ] }, "reaction_10660081": { "compartment": "compartment_263163", "id": "reaction_10660081", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660065" ], "products": [ "species_10659955", "species_10660071", "species_29420" ], "modifiers": [ [ "species_10660078", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375", "Q20759", "WBGene00010045" ] }, "reaction_10660110": { "compartment": "compartment_70101", "id": "reaction_10660110", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660103", "species_113592" ], "products": [ "species_29370", "species_10660107" ], "modifiers": [ [ "species_10646852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10620770": { "compartment": "compartment_70101", "id": "reaction_10620770", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10620720", "species_10620753" ], "products": [ "species_10620768" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "WBGene00022048", "WBGene00006999", "U4PBJ9", "WBGene00022048", "species_113592", "P10984", "WBGene00000064", "Q9U3F4", "WBGene00006999" ] }, "reaction_10622043": { "compartment": "compartment_984", "id": "reaction_10622043", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445", "species_10622041" ], "products": [ "species_10621032" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10622187": { "compartment": "compartment_70101", "id": "reaction_10622187", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620753", "species_10622183" ], "products": [ "species_10622185" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621040": { "compartment": "compartment_984", "id": "reaction_10621040", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621036", "species_10621032" ], "products": [ "species_10621038" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10620762": { "compartment": "compartment_70101", "id": "reaction_10620762", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620758", "species_10620753" ], "products": [ "species_10620760" ], "modifiers": [], "additional_components": [ "WBGene00006836", "WBGene00006999", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621020": { "compartment": "compartment_70101", "id": "reaction_10621020", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612261", "species_10621016" ], "products": [ "species_10621018" ], "modifiers": [], "additional_components": [ "WBGene00003930", "WBGene00003931", "Q9TZC4", "WBGene00003931", "Q27874", "WBGene00003930" ] }, "reaction_10622206": { "compartment": "compartment_70101", "id": "reaction_10622206", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622200", "species_10621016", "species_10622198" ], "products": [ "species_10622204" ], "modifiers": [], "additional_components": [ "O16785", "WBGene00003932", "WBGene00003931", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "O16785", "WBGene00003932", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "Q9TZC4", "WBGene00003931" ] }, "reaction_10622039": { "compartment": "compartment_70101", "id": "reaction_10622039", "reactome": "R-CEL-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622035", "species_10621038" ], "products": [ "species_10622037" ], "modifiers": [], "additional_components": [ "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "P34285", "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10621024": { "compartment": "compartment_70101", "id": "reaction_10621024", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614419", "species_10611919" ], "products": [ "species_10621022" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10609990": { "compartment": "compartment_876", "id": "reaction_10609990", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609944", "species_10609939" ], "products": [ "species_10609988" ], "modifiers": [], "additional_components": [ "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10609992": { "compartment": "compartment_70101", "id": "reaction_10609992", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609988" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10603861": { "compartment": "compartment_7660", "id": "reaction_10603861", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10603858" ], "products": [ "species_113582", "species_10603854" ], "modifiers": [ [ "species_10603858", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605290": { "compartment": "compartment_7660", "id": "reaction_10605290", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603858" ], "products": [ "species_10603858" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10609645": { "compartment": "compartment_984", "id": "reaction_10609645", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609687": { "compartment": "compartment_984", "id": "reaction_10609687", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10609684", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10609670": { "compartment": "compartment_984", "id": "reaction_10609670", "reactome": "R-CEL-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10646409": { "compartment": "compartment_984", "id": "reaction_10646409", "reactome": "R-CEL-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609994": { "compartment": "compartment_984", "id": "reaction_10609994", "reactome": "R-CEL-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609690": { "compartment": "compartment_984", "id": "reaction_10609690", "reactome": "R-CEL-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10650244": { "compartment": "compartment_984", "id": "reaction_10650244", "reactome": "R-CEL-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786438", "species_109276" ], "products": [ "species_6786428", "species_6786426" ], "modifiers": [ [ "species_10650241", "catalyst" ] ], "additional_components": [ "species_1678743", "WBGene00021252" ] }, "reaction_10609998": { "compartment": "compartment_984", "id": "reaction_10609998", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189071", "species_109276" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609697": { "compartment": "compartment_984", "id": "reaction_10609697", "reactome": "R-CEL-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10610000": { "compartment": "compartment_984", "id": "reaction_10610000", "reactome": "R-CEL-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10609996": { "compartment": "compartment_984", "id": "reaction_10609996", "reactome": "R-CEL-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10648681": { "compartment": "compartment_7660", "id": "reaction_10648681", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648674" ], "products": [ "species_113582", "species_113550", "species_10648678" ], "modifiers": [ [ "species_10648674", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q95PZ4", "WBGene00013441", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648331": { "compartment": "compartment_7660", "id": "reaction_10648331", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648306", "species_10648325" ], "products": [ "species_10601816", "species_10648329" ], "modifiers": [], "additional_components": [ "WBGene00006963", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648692": { "compartment": "compartment_7660", "id": "reaction_10648692", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648689", "species_30555" ], "products": [ "species_10648685", "species_113541" ], "modifiers": [ [ "species_10648689", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10648687": { "compartment": "compartment_7660", "id": "reaction_10648687", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10648323" ], "products": [ "species_10648325" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10604545": { "compartment": "compartment_7660", "id": "reaction_10604545", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604541", "species_10604536" ], "products": [ "species_10604543" ], "modifiers": [], "additional_components": [ "WBGene00008140", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10637467": { "compartment": "compartment_876", "id": "reaction_10637467", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614508", "species_10637463" ], "products": [ "species_10637465" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10637471": { "compartment": "compartment_984", "id": "reaction_10637471", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10636719" ], "products": [ "species_10637469" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636627": { "compartment": "compartment_876", "id": "reaction_10636627", "reactome": "R-CEL-2396395", "name": "HSPG2 (perlecan) binds alpha-dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636623", "species_10631599" ], "products": [ "species_10636625" ], "modifiers": [], "additional_components": [ "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "WBGene00006787", "Q22629", "WBGene00000961", "Q06561", "WBGene00006787", "O61756", "WBGene00018943" ] }, "reaction_10636875": { "compartment": "compartment_984", "id": "reaction_10636875", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636871", "species_10636867" ], "products": [ "species_10636873" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "WBGene00002247", "Q10651", "WBGene00000149", "O44565", "WBGene00002247" ] }, "reaction_10649760": { "compartment": "compartment_7660", "id": "reaction_10649760", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649737", "species_10597874" ], "products": [ "species_10649757" ], "modifiers": [ [ "species_10649737", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10649741": { "compartment": "compartment_7660", "id": "reaction_10649741", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649724", "species_10649716" ], "products": [ "species_10649726" ], "modifiers": [], "additional_components": [ "WBGene00010011", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011" ] }, "reaction_10649787": { "compartment": "compartment_7660", "id": "reaction_10649787", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649778" ], "products": [ "species_10649784", "species_10597874" ], "modifiers": [ [ "species_10649778", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649714": { "compartment": "compartment_7660", "id": "reaction_10649714", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10601853", "species_10599971" ], "products": [ "species_10649712" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649719": { "compartment": "compartment_7660", "id": "reaction_10649719", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10649712" ], "products": [ "species_113541", "species_10649716" ], "modifiers": [ [ "species_10649712", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649739": { "compartment": "compartment_7660", "id": "reaction_10649739", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649735", "species_10649726" ], "products": [ "species_10648738", "species_10649737" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q18963", "WBGene00008403", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q23457", "WBGene00004320", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10637202": { "compartment": "compartment_984", "id": "reaction_10637202", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255" ], "products": [ "species_10612257" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636530": { "compartment": "compartment_876", "id": "reaction_10636530", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10612265" ], "products": [ "species_10636528" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10657257": { "compartment": "compartment_20699", "id": "reaction_10657257", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657247", "species_10657253" ], "products": [ "species_10657255" ], "modifiers": [], "additional_components": [ "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q7YWW8", "WBGene00010815", "Q20365", "WBGene00004283", "species_29438", "Q09417", "WBGene00011071" ] }, "reaction_10656786": { "compartment": "compartment_20699", "id": "reaction_10656786", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10656782" ], "products": [ "species_10656784" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q95XZ0", "WBGene00021784", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q6AW08", "WBGene00022121", "Q20797", "WBGene00006373", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305" ] }, "reaction_10657525": { "compartment": "compartment_20699", "id": "reaction_10657525", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10657521" ], "products": [ "species_10657523" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "P34213", "WBGene00004269", "species_29438", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "Q22782", "WBGene00004270", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "P34213", "WBGene00004269", "species_29438", "G5EE66", "WBGene00003258", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "O44502", "WBGene00019820", "Q22782", "WBGene00004270" ] }, "reaction_10657238": { "compartment": "compartment_20699", "id": "reaction_10657238", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657234" ], "products": [ "species_10657236" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10623845": { "compartment": "compartment_876", "id": "reaction_10623845", "reactome": "R-CEL-532603", "name": "Nephrin mediated activation of N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623841", "species_10612328" ], "products": [ "species_10623843" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9TXI8", "WBGene00018215", "Q95PX0", "WBGene00006410", "WBGene00007840", "G5EE56", "WBGene00005077", "Q9TXI8", "WBGene00018215", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410" ] }, "reaction_10615502": { "compartment": "compartment_876", "id": "reaction_10615502", "reactome": "R-CEL-373732", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615464" ], "products": [ "species_10615466" ], "modifiers": [], "additional_components": [ "WBGene00018215", "Q9TXI8", "WBGene00018215" ] }, "reaction_10636526": { "compartment": "compartment_984", "id": "reaction_10636526", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10631430" ], "products": [ "species_10636524" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] } }, "motif_reaction_dictionary": { "reaction_10605393": { "compartment": "compartment_17906", "id": "reaction_10605393", "reactome": "R-CEL-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605391" ], "products": [ "species_10605349" ], "modifiers": [], "additional_components": [ "Q23240", "WBGene00013854", "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "P19974", "WBGene00017121" ] }, "reaction_10605944": { "compartment": "compartment_13231", "id": "reaction_10605944", "reactome": "R-CEL-158441", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604072" ], "products": [ "species_10605942" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10604074": { "compartment": "compartment_7660", "id": "reaction_10604074", "reactome": "R-CEL-77594", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600236", "species_10604068", "species_10602784" ], "products": [ "species_10604072", "species_10600698", "species_10599886" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00000122", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003835", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10605948": { "compartment": "compartment_70101", "id": "reaction_10605948", "reactome": "R-CEL-158447", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605942", "species_10601226" ], "products": [ "species_10602837", "species_10602815", "species_10605946" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00002061", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10646047": { "compartment": "compartment_7660", "id": "reaction_10646047", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604739" ], "products": [ "species_10646044" ], "modifiers": [ [ "species_10604739", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604733": { "compartment": "compartment_7660", "id": "reaction_10604733", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10604730" ], "products": [ "species_10604726", "species_113541" ], "modifiers": [ [ "species_10604730", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q9N3T2", "WBGene00000794", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10604741": { "compartment": "compartment_7660", "id": "reaction_10604741", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604737", "species_10598275" ], "products": [ "species_10604739" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q18547", "WBGene00004339", "Q27474", "WBGene00002985", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10639098": { "compartment": "compartment_70101", "id": "reaction_10639098", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639084" ], "products": [ "species_10639086" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639106": { "compartment": "compartment_70101", "id": "reaction_10639106", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639104", "species_113592" ], "products": [ "species_29370", "species_10639084" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10639096": { "compartment": "compartment_70101", "id": "reaction_10639096", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639086" ], "products": [ "species_10639094" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10659999": { "compartment": "compartment_876", "id": "reaction_10659999", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10659994", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659992": { "compartment": "compartment_70101", "id": "reaction_10659992", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657701", "species_10617312" ], "products": [ "species_10659990" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10659996": { "compartment": "compartment_70101", "id": "reaction_10659996", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10607816" ], "products": [ "species_10659994" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00021320", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660005": { "compartment": "compartment_70101", "id": "reaction_10660005", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10660001" ], "products": [ "species_10660003" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "Q20487", "WBGene00018520", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10660008": { "compartment": "compartment_70101", "id": "reaction_10660008", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10660003", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q20487", "WBGene00018520", "G5EDJ4", "WBGene00004928" ] }, "reaction_10614891": { "compartment": "compartment_7660", "id": "reaction_10614891", "reactome": "R-CEL-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10614881" ], "products": [ "species_113582", "species_10614552" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00003917", "WBGene00000227" ] }, "reaction_10614556": { "compartment": "compartment_13231", "id": "reaction_10614556", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614552" ], "products": [ "species_10614554" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10614561": { "compartment": "compartment_70101", "id": "reaction_10614561", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614554", "species_10597908" ], "products": [ "species_10614558" ], "modifiers": [ [ "species_10614554", "catalyst" ] ], "additional_components": [ "WBGene00003917", "WBGene00006727", "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00003917" ] }, "reaction_10598360": { "compartment": "compartment_7660", "id": "reaction_10598360", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598355", "species_10598298" ], "products": [ "species_10598357" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10609600": { "compartment": "compartment_7660", "id": "reaction_10609600", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_10598355" ], "products": [ "species_10609593" ], "modifiers": [ [ "species_10598355", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00000517" ] }, "reaction_10614563": { "compartment": "compartment_70101", "id": "reaction_10614563", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614558" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q965F9", "WBGene00003917", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10644160": { "compartment": "compartment_70101", "id": "reaction_10644160", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10644150": { "compartment": "compartment_984", "id": "reaction_10644150", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "CHEBI:78587", "CHEBI:78581", "CHEBI:78579", "CHEBI:78584", "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10644111": { "compartment": "compartment_70101", "id": "reaction_10644111", "reactome": "R-CEL-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605853": { "compartment": "compartment_70101", "id": "reaction_10605853", "reactome": "R-CEL-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10603716", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10622150": { "compartment": "compartment_12045", "id": "reaction_10622150", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10622147", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10656532": { "compartment": "compartment_70101", "id": "reaction_10656532", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29356" ], "products": [ "species_109402", "species_29548" ], "modifiers": [ [ "species_10656529", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10625950": { "compartment": "compartment_70101", "id": "reaction_10625950", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10625945" ], "products": [ "species_10625947", "species_29370" ], "modifiers": [ [ "species_10625945", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", 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"WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O62301", "WBGene00010551", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "Q9XWJ1", "WBGene00013188", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625929": { "compartment": "compartment_70101", "id": "reaction_10625929", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625926" ], "products": [ "species_10625911" ], "modifiers": [ [ "species_10625926", "catalyst" ] ], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q93594", "WBGene00009141", "Q09543", "WBGene00003901", "Q9BL68", "WBGene00004884", "O01763", "WBGene00018156", "G5EGK8", "WBGene00002363", "A0A486WX07", "WBGene00002066", "G5EDR3", "WBGene00006352", "D0G912", "WBGene00194816", "O76512", "WBGene00004880", "Q9U302", "WBGene00003902", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q8WQF3", "WBGene00004882", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q09543", "WBGene00003901", "Q8WQA8", "WBGene00004489", "P49029", "WBGene00003123", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "C2BR97", "WBGene00004881", "P49041", "WBGene00004474", "G5EDR3", "WBGene00006352", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q21155", "WBGene00004388", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "G5EGK8", "WBGene00002363", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "G5EDE4", "WBGene00012343", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "Q9BL61", "WBGene00022029", "Q9BL68", "WBGene00004884", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q21832", "WBGene00004387", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10665669": { "compartment": "compartment_17947", "id": "reaction_10665669", "reactome": "R-CEL-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665661" ], "products": [ "species_10665667" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665338": { "compartment": "compartment_18667", "id": "reaction_10665338", "reactome": "R-CEL-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665330" ], "products": [ "species_10665336", "species_10616991", "species_10656088" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "Q22799", "WBGene00001005", "P30644", "WBGene00015264", "species_29420", "Q18817", "WBGene00000248", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q11083", "WBGene00015264", "G5ED34", "WBGene00001007", "H2L2E8", "WBGene00006528", "species_29438", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005" ] }, "reaction_10665685": { "compartment": "compartment_70101", "id": "reaction_10665685", "reactome": "R-CEL-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665651", "species_10642212" ], "products": [ "species_10665653" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "WBGene00015552", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10642254": { "compartment": "compartment_70101", "id": "reaction_10642254", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642201", "species_10642207", "species_10642195", "species_10642193", "species_10642212" ], "products": [ "species_10642214" ], "modifiers": [], "additional_components": [ "WBGene00008236", "WBGene00019900", "WBGene00001509", "WBGene00001509", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665641": { "compartment": "compartment_70101", "id": "reaction_10665641", "reactome": "R-CEL-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665637", "species_10664317" ], "products": [ "species_10665639" ], "modifiers": [], "additional_components": [ "WBGene00000227", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10665679": { "compartment": "compartment_17947", "id": "reaction_10665679", "reactome": "R-CEL-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665675" ], "products": [ "species_10665677" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10665657": { "compartment": "compartment_17947", "id": "reaction_10665657", "reactome": "R-CEL-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642221", "species_10665653" ], "products": [ "species_10665655" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552", "Q23536", "WBGene00002981", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q17746", "WBGene00015552" ] }, "reaction_10662842": { "compartment": "compartment_21994", "id": "reaction_10662842", "reactome": "R-CEL-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662838", "species_10642246" ], "products": [ "species_10662840" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q22252", "WBGene00011528", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q23536", "WBGene00002981", "Q10931", "WBGene00002982", "Q22252", "WBGene00011528" ] }, "reaction_10642225": { "compartment": "compartment_70101", "id": "reaction_10642225", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10642214" ], "products": [ "species_10642223" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q23536", "WBGene00002981", "Q18746", "WBGene00008236", "Q17746", "WBGene00015552" ] }, "reaction_10665671": { "compartment": "compartment_17947", "id": "reaction_10665671", "reactome": "R-CEL-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665643", "species_10665659" ], "products": [ "species_10665661" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "WBGene00000227", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10662844": { "compartment": "compartment_70101", "id": "reaction_10662844", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642219", "species_10661490" ], "products": [ "species_10662838" ], "modifiers": [], "additional_components": [ "WBGene00002981", "WBGene00011528", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10661493": { "compartment": "compartment_17906", "id": "reaction_10661493", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661490" ], "modifiers": [ [ "species_10661471", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10665228": { "compartment": "compartment_70101", "id": "reaction_10665228", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665220", "species_10665224" ], "products": [ "species_10665226" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642252": { "compartment": "compartment_17906", "id": "reaction_10642252", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642230" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665284": { "compartment": "compartment_70101", "id": "reaction_10665284", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665226" ], "products": [ "species_10665282" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10661481": { "compartment": "compartment_70101", "id": "reaction_10661481", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661463" ], "products": [ "species_10661460" ], "modifiers": [ [ "species_10661478", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10661465": { "compartment": "compartment_70101", "id": "reaction_10661465", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661460" ], "products": [ "species_29370", "species_10661463" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665286": { "compartment": "compartment_70101", "id": "reaction_10665286", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665282" ], "products": [ "species_10665256" ], "modifiers": [], "additional_components": [ "O45495", "WBGene00006730", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95XX0", "WBGene00006708", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "O45495", "WBGene00006730", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349" ] }, "reaction_10642258": { "compartment": "compartment_17927", "id": "reaction_10642258", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642234" ], "products": [ "species_10642256" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10665683": { "compartment": "compartment_17947", "id": "reaction_10665683", "reactome": "R-CEL-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665667" ], "products": [ "species_10665651" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661487": { "compartment": "compartment_70101", "id": "reaction_10661487", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661463" ], "products": [ "species_29370", "species_10661484" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00005077" ] }, "reaction_10665320": { "compartment": "compartment_70101", "id": "reaction_10665320", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665316", "species_10656088" ], "products": [ "species_10665318" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "Q9U266", "WBGene00001838", "P0CG71", "WBGene00006727", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "O45087", "WBGene00015927", "G5ED34", "WBGene00001007", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "O45087", "WBGene00015927", "Q11083", "WBGene00015264", "Q19625", "WBGene00003412", "A0A2C9C3L3", "WBGene00015264", "G5ED34", "WBGene00001007", "Q22799", "WBGene00001005", "P0CG71", "WBGene00006727", "H2L0N8", "WBGene00021349", "P30644", "WBGene00015264", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "P90994", "WBGene00015184", "Q95QV2", "WBGene00000477", "A0AAC1", "WBGene00012424", "Q9U266", "WBGene00001838", "G5ED37", "WBGene00003885" ] }, "reaction_10665681": { "compartment": "compartment_70101", "id": "reaction_10665681", "reactome": "R-CEL-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665639" ], "products": [ "species_10665659" ], "modifiers": [], "additional_components": [ "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194", "Q9N3Q4", "WBGene00000227", "Q18426", "WBGene00004194" ] }, "reaction_10661473": { "compartment": "compartment_17906", "id": "reaction_10661473", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646604" ], "products": [ "species_10661471" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10624305": { "compartment": "compartment_876", "id": "reaction_10624305", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10624302", "catalyst" ] ], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10624483": { "compartment": "compartment_984", "id": "reaction_10624483", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624300", "species_372533" ], "products": [ "species_10624302" ], "modifiers": [], "additional_components": [ "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "Q93323", "WBGene00007903", "H2KZY7", "WBGene00022283", "Q9N587", "WBGene00006797", "species_264643", "Q93323", "WBGene00007903" ] }, "reaction_10656521": { "compartment": "compartment_172574", "id": "reaction_10656521", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656517" ], "products": [ "species_10656519" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10656524": { "compartment": "compartment_7660", "id": "reaction_10656524", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_113550", "species_6810408" ], "modifiers": [ [ "species_10656519", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10656818": { "compartment": "compartment_7660", "id": "reaction_10656818", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10656815", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10611022": { "compartment": "compartment_7660", "id": "reaction_10611022", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10607257", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664813": { "compartment": "compartment_70101", "id": "reaction_10664813", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607886" ], "products": [ "species_10611039" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664806": { "compartment": "compartment_70101", "id": "reaction_10664806", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664792", "species_113592" ], "products": [ "species_29370", "species_10664801" ], "modifiers": [ [ "species_10664792", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10664790": { "compartment": "compartment_74700", "id": "reaction_10664790", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10664786", "species_10647064" ], "products": [ "species_10664788" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10612228": { "compartment": "compartment_876", "id": "reaction_10612228", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10605404" ], "products": [ "species_10612226" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10664854": { "compartment": "compartment_7660", "id": "reaction_10664854", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664849", "species_29358" ], "products": [ "species_113582", "species_10664852" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10611305": { "compartment": "compartment_7660", "id": "reaction_10611305", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611302", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10664811": { "compartment": "compartment_74700", "id": "reaction_10664811", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664808" ], "products": [ "species_29370", "species_10664786" ], "modifiers": [ [ "species_10664808", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10611033": { "compartment": "compartment_7660", "id": "reaction_10611033", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611029" ], "products": [ "species_10611031" ], "modifiers": [], "additional_components": [ "WBGene00004859", "WBGene00004859" ] }, "reaction_10611296": { "compartment": "compartment_7660", "id": "reaction_10611296", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611290" ], "products": [ "species_113582", "species_10611293" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10611307": { "compartment": "compartment_7660", "id": "reaction_10611307", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611019", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10664803": { "compartment": "compartment_70101", "id": "reaction_10664803", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664801" ], "products": [ "species_10618752", "species_10647089", "species_10664786" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10664844": { "compartment": "compartment_7660", "id": "reaction_10664844", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10664841", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789" ] }, "reaction_10607457": { "compartment": "compartment_876", "id": "reaction_10607457", "reactome": "R-CEL-169904", "name": "C3G stimulates nucleotide exchange on Rap1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607452" ], "products": [ "species_10607454", "species_29420" ], "modifiers": [ [ "species_10607443", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10612373": { "compartment": "compartment_7660", "id": "reaction_10612373", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10612370", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10607466": { "compartment": "compartment_876", "id": "reaction_10607466", "reactome": "R-CEL-169905", "name": "ARMS is phosphorylated by active TrkA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607463" ], "products": [ "species_29370", "species_10607443" ], "modifiers": [ [ "species_10607463", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "G5EGK5", "WBGene00000289", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10607846": { "compartment": "compartment_876", "id": "reaction_10607846", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10607842" ], "products": [ "species_10607844" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017891", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10647187": { "compartment": "compartment_70101", "id": "reaction_10647187", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618752" ], "products": [ "species_10607886" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10607820": { "compartment": "compartment_74700", "id": "reaction_10607820", "reactome": "R-CEL-170978", "name": "p-FRS2:CRKL binds C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607816", "species_10607811" ], "products": [ "species_10607818" ], "modifiers": [], "additional_components": [ "WBGene00021320", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "E6N0V1", "WBGene00018819", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "H2KZX7", "WBGene00021320", "E6N0V1", "WBGene00018819" ] }, "reaction_10664799": { "compartment": "compartment_74700", "id": "reaction_10664799", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664788", "species_113592" ], "products": [ "species_10664792", "species_29370" ], "modifiers": [ [ "species_10664788", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438", "Q18246", "WBGene00004307", "Q20655", "WBGene00001502", "species_216667", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "species_29438" ] }, "reaction_10609591": { "compartment": "compartment_70101", "id": "reaction_10609591", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609556" ], "products": [ "species_29370", "species_10609574" ], "modifiers": [ [ "species_10609588", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496" ] }, "reaction_10611336": { "compartment": "compartment_7660", "id": "reaction_10611336", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611311" ], "products": [ "species_113550", "species_10611329" ], "modifiers": [ [ "species_10611333", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "G5EBT1", "WBGene00004859", "U4PDY6", "WBGene00019665", "A9UJN4", "WBGene00007554", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10607445": { "compartment": "compartment_984", "id": "reaction_10607445", "reactome": "R-CEL-169895", "name": "Crk's SH3 domain engages C3G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607443" ], "products": [ "species_10607443" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490", "Q9NHC3", "WBGene00000416", "G5EGK5", "WBGene00000289", "Q95XA9", "WBGene00021238", "A0A061AD72", "WBGene00006490" ] }, "reaction_10611042": { "compartment": "compartment_7660", "id": "reaction_10611042", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611013" ], "products": [ "species_113582", "species_10611019" ], "modifiers": [ [ "species_10611039", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10664875": { "compartment": "compartment_7660", "id": "reaction_10664875", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640193", "species_10664859", "species_10664871" ], "products": [ "species_10664873" ], "modifiers": [], "additional_components": [ "WBGene00002637", "WBGene00003107", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "U4PBA8", "WBGene00043705", "U4PLQ8", "WBGene00044651", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22002", "WBGene00003107", "U4PBA8", "WBGene00043705" ] }, "reaction_10637627": { "compartment": "compartment_876", "id": "reaction_10637627", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10614487" ], "products": [ "species_10637625" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10637623": { "compartment": "compartment_876", "id": "reaction_10637623", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10637619" ], "products": [ "species_10637621" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "P50605", "WBGene00004749" ] }, "reaction_10637924": { "compartment": "compartment_876", "id": "reaction_10637924", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637920", "species_10618504" ], "products": [ "species_10637922" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10637535": { "compartment": "compartment_876", "id": "reaction_10637535", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635080", "species_10609836" ], "products": [ "species_10637533" ], "modifiers": [], "additional_components": [ "WBGene00004749", "WBGene00002881", "Q11184", "WBGene00002881", "P50605", "WBGene00004749" ] }, "reaction_10638478": { "compartment": "compartment_70101", "id": "reaction_10638478", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638466", "species_3134861" ], "products": [ "species_10638468" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10638476": { "compartment": "compartment_70101", "id": "reaction_10638476", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638470", "species_3134861" ], "products": [ "species_10638472" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10622778": { "compartment": "compartment_876", "id": "reaction_10622778", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622774", "species_210382" ], "products": [ "species_10622776" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006", "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10622781": { "compartment": "compartment_70101", "id": "reaction_10622781", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10622776", "catalyst" ] ], "additional_components": [ "P36609", "WBGene00003564", "Q94288", "WBGene00000287", "A0A1T5HUM0", "WBGene00001618", "Q18136", "WBGene00006861", "species_113552", "O02217", "WBGene00007710", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P04630", "WBGene00000285", "P34299", "WBGene00001612", "Q09980", "WBGene00017394", "Q8MXV8", "WBGene00001617", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "Q21415", "WBGene00001614", "O02159", "WBGene00020378", "Q10914", "WBGene00001613", "species_188972", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "G5ECY0", "WBGene00001006" ] }, "reaction_10598836": { "compartment": "compartment_70101", "id": "reaction_10598836", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10598833", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10598710": { "compartment": "compartment_5460", "id": "reaction_10598710", "reactome": "R-CEL-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10598707", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "WBGene00004259" ] }, "reaction_10622848": { "compartment": "compartment_5460", "id": "reaction_10622848", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10622845", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10598720": { "compartment": "compartment_70101", "id": "reaction_10598720", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10598717", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10607315": { "compartment": "compartment_7660", "id": "reaction_10607315", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607308" ], "products": [ "species_113582", "species_10607312" ], "modifiers": [ [ "species_10607290", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10607375": { "compartment": "compartment_7660", "id": "reaction_10607375", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_10607312" ], "products": [ "species_10607373" ], "modifiers": [], "additional_components": [ "WBGene00000223", "WBGene00012005", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10622474": { "compartment": "compartment_70101", "id": "reaction_10622474", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622458" ], "products": [ "species_10622472" ], "modifiers": [], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607371": { "compartment": "compartment_70101", "id": "reaction_10607371", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607329" ], "products": [ "species_29370", "species_10607343" ], "modifiers": [ [ "species_10607368", "catalyst" ] ], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "O01706", "WBGene00012162", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10622491": { "compartment": "compartment_7660", "id": "reaction_10622491", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622488" ], "products": [ "species_113582", "species_10622403" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10607303": { "compartment": "compartment_7660", "id": "reaction_10607303", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607226" ], "products": [ "species_113582", "species_10607230" ], "modifiers": [ [ "species_10607300", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "P39745", "WBGene00003401", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "Q17446", "WBGene00004055", "U4PDY6", "WBGene00019665" ] }, "reaction_10622517": { "compartment": "compartment_70101", "id": "reaction_10622517", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343" ], "products": [ "species_10607290" ], "modifiers": [], "additional_components": [ "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178" ] }, "reaction_10622418": { "compartment": "compartment_7660", "id": "reaction_10622418", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622403" ], "products": [ "species_113582", "species_10622415" ], "modifiers": [ [ "species_10622403", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10622422": { "compartment": "compartment_70101", "id": "reaction_10622422", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622415" ], "products": [ "species_10622420" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10628646": { "compartment": "compartment_70101", "id": "reaction_10628646", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628641" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628643" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00022048", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "U4PBJ9", "WBGene00022048", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10625395": { "compartment": "compartment_13231", "id": "reaction_10625395", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625381" ], "products": [ "species_10625389", "species_10625393", "species_10625391" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00002075", "WBGene00009956" ] }, "reaction_10628669": { "compartment": "compartment_70101", "id": "reaction_10628669", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_113592", "species_10628665" ], "products": [ "species_10627823", "species_10628632", "species_10628667", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10663507": { "compartment": "compartment_70101", "id": "reaction_10663507", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8983696", "species_29356" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10663504", "catalyst" ] ], "additional_components": [ "species_113592", "WBGene00011268" ] }, "reaction_10633391": { "compartment": "compartment_70101", "id": "reaction_10633391", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628679" ], "products": [ "species_141681", "species_10628677" ], "modifiers": [ [ "species_10633388", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "Q22240", "WBGene00011507" ] }, "reaction_10633412": { "compartment": "compartment_70101", "id": "reaction_10633412", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633398", "species_10633408" ], "products": [ "species_10633410", "species_10633406" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10666093": { "compartment": "compartment_70101", "id": "reaction_10666093", "reactome": "R-CEL-9710963", "name": "p-STAT1dimer:KPNA1 binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666087", "species_10614210" ], "products": [ "species_10666091" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956", "WBGene00002075", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628681": { "compartment": "compartment_70101", "id": "reaction_10628681", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628677", "species_10628634", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_111294", "species_76577", "species_10628679" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006713", "WBGene00016158", "P39745", "WBGene00003401", "O44820", "WBGene00018660", "Q8WQC9", "WBGene00001093", "Q22070", "WBGene00004038", "G5EDI8", "WBGene00001090", "Q9NAD6", "WBGene00013111", "U4PDY6", "WBGene00019665", "Q93413", "WBGene00008400", "Q19192", "WBGene00003970", "Q20977", "WBGene00010251", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10666089": { "compartment": "compartment_70101", "id": "reaction_10666089", "reactome": "R-CEL-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614205", "species_10625312" ], "products": [ "species_10666087" ], "modifiers": [], "additional_components": [ "WBGene00009956", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20703", "WBGene00009956" ] }, "reaction_10628650": { "compartment": "compartment_70101", "id": "reaction_10628650", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_10627458" ], "products": [ "species_10628648" ], "modifiers": [], "additional_components": [ "WBGene00018660", "WBGene00022358", "O44820", "WBGene00018660", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10633414": { "compartment": "compartment_70101", "id": "reaction_10633414", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10633396" ], "products": [ "species_10633398" ], "modifiers": [], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00002062", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "O01965", "WBGene00016158" ] }, "reaction_10625031": { "compartment": "compartment_13231", "id": "reaction_10625031", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625021" ], "products": [ "species_10625029" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628639": { "compartment": "compartment_70101", "id": "reaction_10628639", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628625", "species_113592", "species_10627828" ], "products": [ "species_111294", "species_10628636", "species_76577" ], "modifiers": [ [ "species_10627828", "catalyst" ] ], "additional_components": [ "WBGene00018660", "WBGene00006699", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "WBGene00006699" ] }, "reaction_10628659": { "compartment": "compartment_70101", "id": "reaction_10628659", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627823", "species_10628636" ], "products": [ "species_10628627", "species_10627828" ], "modifiers": [ [ "species_10627823", "catalyst" ] ], "additional_components": [ "WBGene00006713", "Q27481", "WBGene00006699", "O44820", "WBGene00018660", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "WBGene00006699", "WBGene00006713" ] }, "reaction_10628654": { "compartment": "compartment_70101", "id": "reaction_10628654", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628634", "species_10612207", "species_113592" ], "products": [ "species_10627823", "species_10628632", "species_10628652", "species_111294", "species_76577" ], "modifiers": [ [ "species_10628634", "catalyst" ] ], "additional_components": [ "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158", "WBGene00006708", "WBGene00006713", "WBGene00016158", "O44820", "WBGene00018660", "Q95XX0", "WBGene00006708", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10628656": { "compartment": "compartment_70101", "id": "reaction_10628656", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628632", "species_10628627" ], "products": [ "species_10628634" ], "modifiers": [], "additional_components": [ "WBGene00016158", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O44820", "WBGene00018660", "Q21633", "WBGene00006713", "O01965", "WBGene00016158" ] }, "reaction_10657691": { "compartment": "compartment_17963", "id": "reaction_10657691", "reactome": "R-CEL-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657686" ], "products": [ "species_10609860" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00002881" ] }, "reaction_10646301": { "compartment": "compartment_70101", "id": "reaction_10646301", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636505", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646280": { "compartment": "compartment_70101", "id": "reaction_10646280", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646277", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646291": { "compartment": "compartment_70101", "id": "reaction_10646291", "reactome": "R-CEL-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608561", "species_10636509" ], "products": [ "species_10636511" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646246": { "compartment": "compartment_984", "id": "reaction_10646246", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646242", "species_190915" ], "products": [ "species_10646244" ], "modifiers": [], "additional_components": [ "WBGene00002181", "G5EDX1", "WBGene00002181", "species_190915" ] }, "reaction_10646181": { "compartment": "compartment_70101", "id": "reaction_10646181", "reactome": "R-CEL-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646176", "species_113592" ], "products": [ "species_10646178", "species_29370" ], "modifiers": [ [ "species_10646176", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646260": { "compartment": "compartment_876", "id": "reaction_10646260", "reactome": "R-CEL-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10636501" ], "modifiers": [ [ "species_10646248", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646204": { "compartment": "compartment_70101", "id": "reaction_10646204", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646201", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646197": { "compartment": "compartment_70101", "id": "reaction_10646197", "reactome": "R-CEL-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646194", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646267": { "compartment": "compartment_70101", "id": "reaction_10646267", "reactome": "R-CEL-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646192" ], "products": [ "species_10646194" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646298": { "compartment": "compartment_70101", "id": "reaction_10646298", "reactome": "R-CEL-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10646289" ], "products": [ "species_10646293" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646265": { "compartment": "compartment_876", "id": "reaction_10646265", "reactome": "R-CEL-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646262" ], "products": [ "species_29370", "species_10646190" ], "modifiers": [ [ "species_10646262", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10657689": { "compartment": "compartment_17963", "id": "reaction_10657689", "reactome": "R-CEL-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10657684" ], "products": [ "species_205687", "species_10657686" ], "modifiers": [ [ "species_10625450", "catalyst" ] ], "additional_components": [ "WBGene00002881", "WBGene00002881", "P34678", "WBGene00001628", "O61394", "WBGene00001631" ] }, "reaction_10608563": { "compartment": "compartment_70101", "id": "reaction_10608563", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10608459" ], "products": [ "species_10608561" ], "modifiers": [], "additional_components": [ "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646269": { "compartment": "compartment_70101", "id": "reaction_10646269", "reactome": "R-CEL-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636501", "species_10608561" ], "products": [ "species_10636503" ], "modifiers": [], "additional_components": [ "E6N0V1", "WBGene00018819", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10646253": { "compartment": "compartment_70101", "id": "reaction_10646253", "reactome": "R-CEL-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646248" ], "products": [ "species_29370", "species_10646250" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10646174": { "compartment": "compartment_70101", "id": "reaction_10646174", "reactome": "R-CEL-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646169" ], "products": [ "species_29370", "species_10646171" ], "modifiers": [ [ "species_10646169", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "species_179838", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "species_179838" ] }, "reaction_10646255": { "compartment": "compartment_70101", "id": "reaction_10646255", "reactome": "R-CEL-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10646221" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10655619": { "compartment": "compartment_7660", "id": "reaction_10655619", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599987", "species_10655615", "species_10600001" ], "products": [ "species_10655617" ], "modifiers": [], "additional_components": [ "WBGene00004207", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q4W5P0", "WBGene00022235", "P34541", "WBGene00019881", "Q9U3I0", "WBGene00009078", "Q18999", "WBGene00004207", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q4W5P0", "WBGene00022235", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "P34541", "WBGene00019881", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10646223": { "compartment": "compartment_876", "id": "reaction_10646223", "reactome": "R-CEL-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646208" ], "products": [ "species_29370", "species_10636509" ], "modifiers": [ [ "species_10646208", "catalyst" ], [ "species_10646221", "inhibitor" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646287": { "compartment": "compartment_876", "id": "reaction_10646287", "reactome": "R-CEL-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646282" ], "products": [ "species_29370", "species_10646284" ], "modifiers": [ [ "species_10646282", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819", "E6N0V1", "WBGene00018819" ] }, "reaction_10646296": { "compartment": "compartment_70101", "id": "reaction_10646296", "reactome": "R-CEL-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10646293", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "Q9N5D3", "WBGene00004947" ] }, "reaction_10646237": { "compartment": "compartment_876", "id": "reaction_10646237", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646233", "species_10646231", "species_190915" ], "products": [ "species_10646235" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881", "Q95XJ7", "WBGene00022418", "Q95XJ7", "WBGene00022418", "species_190915", "G5EEF1", "WBGene00001185", "Q11184", "WBGene00002881" ] }, "reaction_10646304": { "compartment": "compartment_70101", "id": "reaction_10646304", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636513", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001" ] }, "reaction_10638456": { "compartment": "compartment_70101", "id": "reaction_10638456", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638454" ], "products": [ "species_10638452" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10632792": { "compartment": "compartment_70101", "id": "reaction_10632792", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10632789", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10632759": { "compartment": "compartment_70101", "id": "reaction_10632759", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10664432": { "compartment": "compartment_5460", "id": "reaction_10664432", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664428" ], "products": [ "species_10639552", "species_1655881", "species_10663602" ], "modifiers": [], "additional_components": [ "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307", "WBGene00007099", "WBGene00011307" ] }, "reaction_10663852": { "compartment": "compartment_5460", "id": "reaction_10663852", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10632779": { "compartment": "compartment_70101", "id": "reaction_10632779", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632742": { "compartment": "compartment_70616", "id": "reaction_10632742", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10664426": { "compartment": "compartment_5460", "id": "reaction_10664426", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663602", "species_9012592" ], "products": [ "species_10664424", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307", "WBGene00011307", "WBGene00011307" ] }, "reaction_10632740": { "compartment": "compartment_5460", "id": "reaction_10632740", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10632737", "catalyst" ] ], "additional_components": [ "species_947539", "Q9XTQ8", "WBGene00010397" ] }, "reaction_10663887": { "compartment": "compartment_5460", "id": "reaction_10663887", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10664430": { "compartment": "compartment_5460", "id": "reaction_10664430", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664424", "species_10639549" ], "products": [ "species_10664428" ], "modifiers": [], "additional_components": [ "WBGene00011307", "WBGene00007099", "Q17424", "WBGene00007099", "G5EEV0", "WBGene00011307" ] }, "reaction_10632782": { "compartment": "compartment_70101", "id": "reaction_10632782", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632777": { "compartment": "compartment_70616", "id": "reaction_10632777", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10632765", "species_113521" ], "products": [ "species_10632767", "species_1614538", "species_113529" ], "modifiers": [ [ "species_10632774", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "species_216667", "O17636", "WBGene00007886" ] }, "reaction_10632753": { "compartment": "compartment_70101", "id": "reaction_10632753", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10632750", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10663605": { "compartment": "compartment_5460", "id": "reaction_10663605", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10656962": { "compartment": "compartment_70101", "id": "reaction_10656962", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10656959", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10663885": { "compartment": "compartment_5460", "id": "reaction_10663885", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10663602", "catalyst" ] ], "additional_components": [ "WBGene00011307" ] }, "reaction_10657228": { "compartment": "compartment_12045", "id": "reaction_10657228", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10657225", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398", "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399" ] }, "reaction_10623933": { "compartment": "compartment_70101", "id": "reaction_10623933", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10623928", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10648592": { "compartment": "compartment_161320", "id": "reaction_10648592", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10648589", "catalyst" ] ], "additional_components": [ "species_6785219", "species_390435", "WBGene00004092" ] }, "reaction_10623940": { "compartment": "compartment_70101", "id": "reaction_10623940", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_29768", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_548819" ], "modifiers": [ [ "species_10623937", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10602893": { "compartment": "compartment_70101", "id": "reaction_10602893", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10602885", "catalyst" ], [ "species_10602891", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10611701": { "compartment": "compartment_70101", "id": "reaction_10611701", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10611698", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "O44560", "WBGene00020343", "A0A4V0ING4", "WBGene00016716", "V6CLI5", "WBGene00022037", "O16775", "WBGene00019920", "Q21872", "WBGene00011173" ] }, "reaction_10602965": { "compartment": "compartment_70101", "id": "reaction_10602965", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10602962", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10647332": { "compartment": "compartment_12045", "id": "reaction_10647332", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10647329", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517", "Q21905", "WBGene00011205" ] }, "reaction_10623876": { "compartment": "compartment_70101", "id": "reaction_10623876", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10623920": { "compartment": "compartment_70101", "id": "reaction_10623920", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10623917", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20904", "WBGene00001245", "Q20300", "WBGene00001243", "Q03574", "WBGene00001242", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241" ] }, "reaction_10611571": { "compartment": "compartment_70101", "id": "reaction_10611571", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602921", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10623923": { "compartment": "compartment_70101", "id": "reaction_10623923", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10610418", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10606634": { "compartment": "compartment_70101", "id": "reaction_10606634", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602960" ], "products": [ "species_10602962" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10648602": { "compartment": "compartment_12045", "id": "reaction_10648602", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_4085415", "species_428139" ], "products": [ "species_5690558", "species_29356", "species_4085425" ], "modifiers": [ [ "species_10648599", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10602902": { "compartment": "compartment_70101", "id": "reaction_10602902", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10664094": { "compartment": "compartment_70101", "id": "reaction_10664094", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9023653" ], "products": [ "species_9023651", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664092": { "compartment": "compartment_70101", "id": "reaction_10664092", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10662619": { "compartment": "compartment_17947", "id": "reaction_10662619", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662607" ], "products": [ "species_10662616", "species_10628859" ], "modifiers": [ [ "species_10662607", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10660992": { "compartment": "compartment_70101", "id": "reaction_10660992", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660981", "species_10660979" ], "products": [ "species_10612207", "species_10660989", "species_10660972" ], "modifiers": [ [ "species_10660981", "catalyst" ] ], "additional_components": [ "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10660994": { "compartment": "compartment_70101", "id": "reaction_10660994", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660979", "species_10660972", "species_10660974" ], "products": [ "species_10660981" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "species_29420", "Q19214", "WBGene00008588", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "Q22743", "WBGene00006414" ] }, "reaction_10662609": { "compartment": "compartment_17947", "id": "reaction_10662609", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662605", "species_10662601" ], "products": [ "species_10662607" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10643471": { "compartment": "compartment_12045", "id": "reaction_10643471", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10643464" ], "products": [ "species_10643468" ], "modifiers": [ [ "species_10643464", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q20798", "WBGene00004768", "P54812", "WBGene00008053", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667" ] }, "reaction_10645821": { "compartment": "compartment_261122", "id": "reaction_10645821", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645817" ], "products": [ "species_10645819" ], "modifiers": [], "additional_components": [ "WBGene00004210", "WBGene00004210" ] }, "reaction_10644533": { "compartment": "compartment_876", "id": "reaction_10644533", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10644526", "catalyst" ], [ "species_10644531", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645932": { "compartment": "compartment_7660", "id": "reaction_10645932", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645929", "species_10597874" ], "products": [ "species_10645923" ], "modifiers": [ [ "species_10645929", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320" ] }, "reaction_10644620": { "compartment": "compartment_70101", "id": "reaction_10644620", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627451", "species_10621559" ], "products": [ "species_10644618" ], "modifiers": [], "additional_components": [ "WBGene00007009", "WBGene00003830", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10644632": { "compartment": "compartment_5263232", "id": "reaction_10644632", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10644628" ], "products": [ "species_10644622", "species_10644630" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10644522": { "compartment": "compartment_18730", "id": "reaction_10644522", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644487", "species_10644518" ], "products": [ "species_10644520" ], "modifiers": [], "additional_components": [ "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q09306", "WBGene00006655", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490" ] }, "reaction_10645925": { "compartment": "compartment_7660", "id": "reaction_10645925", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645923" ], "products": [ "species_10645921", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "H2KYJ3", "WBGene00015567", "P34371", "WBGene00016803", "Q94420", "WBGene00003209", "P41886", "WBGene00018137", "Q17391", "WBGene00000838", "Q9NF14", "WBGene00013689", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10608347": { "compartment": "compartment_70101", "id": "reaction_10608347", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176667" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10629186": { "compartment": "compartment_70101", "id": "reaction_10629186", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10629183", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10608127": { "compartment": "compartment_70101", "id": "reaction_10608127", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10608120" ], "products": [ "species_10608124", "species_174390" ], "modifiers": [ [ "species_10608120", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10608162": { "compartment": "compartment_70101", "id": "reaction_10608162", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10608159", "catalyst" ] ], "additional_components": [ "P27604", "WBGene00019322", "species_29360" ] }, "reaction_10662568": { "compartment": "compartment_17963", "id": "reaction_10662568", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10662565", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "Q5ZEQ3", "WBGene00012390", "species_109496" ] }, "reaction_10606293": { "compartment": "compartment_70101", "id": "reaction_10606293", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158858" ], "products": [ "species_158850", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608369": { "compartment": "compartment_70101", "id": "reaction_10608369", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176575" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608104": { "compartment": "compartment_12045", "id": "reaction_10608104", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10608101", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10608191": { "compartment": "compartment_70101", "id": "reaction_10608191", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_175973" ], "products": [ "species_71285", "species_175979" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10661289": { "compartment": "compartment_876", "id": "reaction_10661289", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247892", "species_109276" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10598417": { "compartment": "compartment_70101", "id": "reaction_10598417", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10598414", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10606403": { "compartment": "compartment_5460", "id": "reaction_10606403", "reactome": "R-CEL-159574", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159557", "species_159549" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10608094": { "compartment": "compartment_70101", "id": "reaction_10608094", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_29404" ], "products": [ "species_29370", "species_174393", "species_29372" ], "modifiers": [ [ "species_10608091", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10608137": { "compartment": "compartment_70101", "id": "reaction_10608137", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174370", "species_113592" ], "products": [ "species_158471", "species_29370" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10608340": { "compartment": "compartment_70101", "id": "reaction_10608340", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10608337", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608374": { "compartment": "compartment_70101", "id": "reaction_10608374", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10608371", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606330": { "compartment": "compartment_70101", "id": "reaction_10606330", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10624752": { "compartment": "compartment_20699", "id": "reaction_10624752", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10624749", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10619928": { "compartment": "compartment_876", "id": "reaction_10619928", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10619925", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10654763": { "compartment": "compartment_70101", "id": "reaction_10654763", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10608355": { "compartment": "compartment_70101", "id": "reaction_10608355", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10608352", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10629176": { "compartment": "compartment_70101", "id": "reaction_10629176", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10608366": { "compartment": "compartment_70101", "id": "reaction_10608366", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_5695950" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10608363", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606401": { "compartment": "compartment_5460", "id": "reaction_10606401", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10639385": { "compartment": "compartment_5460", "id": "reaction_10639385", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3301954", "species_1655887" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10639382", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10608140": { "compartment": "compartment_70101", "id": "reaction_10608140", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174375", "species_113592" ], "products": [ "species_174370", "species_111294" ], "modifiers": [ [ "species_10608132", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10629196": { "compartment": "compartment_70101", "id": "reaction_10629196", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10629193", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10649482": { "compartment": "compartment_70101", "id": "reaction_10649482", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_5696224", "species_29356", "species_111745" ], "modifiers": [ [ "species_10608209", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10608345": { "compartment": "compartment_70101", "id": "reaction_10608345", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176619" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10607919": { "compartment": "compartment_70101", "id": "reaction_10607919", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_158601" ], "modifiers": [ [ "species_10607916", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10608150": { "compartment": "compartment_70101", "id": "reaction_10608150", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10608147", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q21549", "WBGene00010941", "species_109496" ] }, "reaction_10605958": { "compartment": "compartment_70101", "id": "reaction_10605958", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158469" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10606295": { "compartment": "compartment_70101", "id": "reaction_10606295", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_158847" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10605955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608357": { "compartment": "compartment_70101", "id": "reaction_10608357", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608343": { "compartment": "compartment_70101", "id": "reaction_10608343", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_193103" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10608331", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10608256": { "compartment": "compartment_70101", "id": "reaction_10608256", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10608253", "catalyst" ] ], "additional_components": [ "species_76396", "species_3301954", "CHEBI:30614", "CHEBI:34479", "species_9753685", "species_3301969", "O45352", "WBGene00001792", "O45010", "WBGene00021127", "P34345", "WBGene00016204", "Q09596", "WBGene00001753", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337", "Q18938", "WBGene00001790", "P10299", "WBGene00001749" ] }, "reaction_10648957": { "compartment": "compartment_17957", "id": "reaction_10648957", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10648954", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10606424": { "compartment": "compartment_20699", "id": "reaction_10606424", "reactome": "R-CEL-159728", "name": "Furin cleaves pro-prothrombin to prothrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606405" ], "products": [ "species_10606409", "species_10606407" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "WBGene00008879", "WBGene00008879", "WBGene00008879", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10650363": { "compartment": "compartment_12045", "id": "reaction_10650363", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10650360", "catalyst" ] ], "additional_components": [ "species_216667", "P91402", "WBGene00019710" ] }, "reaction_10643368": { "compartment": "compartment_70101", "id": "reaction_10643368", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643348", "species_71284" ], "products": [ "species_353106", "species_10643335" ], "modifiers": [ [ "species_10643365", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "Q09454", "WBGene00007488", "P49958", "WBGene00007576", "Q21102", "WBGene00010484" ] }, "reaction_10606692": { "compartment": "compartment_20699", "id": "reaction_10606692", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606676" ], "products": [ "species_10606684", "species_10606690" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10643346": { "compartment": "compartment_70101", "id": "reaction_10643346", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643335", "species_71284" ], "products": [ "species_10643338", "species_71285" ], "modifiers": [ [ "species_10643343", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10650384": { "compartment": "compartment_70101", "id": "reaction_10650384", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_29370", "species_6788858" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10606430": { "compartment": "compartment_13959", "id": "reaction_10606430", "reactome": "R-CEL-159843", "name": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606428" ], "products": [ "species_10606405" ], "modifiers": [], "additional_components": [ "WBGene00008879", "WBGene00008879" ] }, "reaction_10613073": { "compartment": "compartment_70101", "id": "reaction_10613073", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_204628" ], "products": [ "species_29360", "species_204635", "species_10613063" ], "modifiers": [ [ "species_10613070", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10606678": { "compartment": "compartment_13959", "id": "reaction_10606678", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670" ], "products": [ "species_10606676" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10650386": { "compartment": "compartment_70101", "id": "reaction_10650386", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788868", "species_113592" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10650381", "catalyst" ] ], "additional_components": [ "CHEBI:24103", "CHEBI:87176", "CHEBI:87177", "CHEBI:87178", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10643332": { "compartment": "compartment_70101", "id": "reaction_10643332", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643324", "species_113592", "species_31633" ], "products": [ "species_10605934", "species_111294", "species_76577" ], "modifiers": [ [ "species_10643329", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10613101": { "compartment": "compartment_70101", "id": "reaction_10613101", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10613049", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10613091" ], "modifiers": [ [ "species_10613098", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "species_113531", "Q17949", "WBGene00007555" ] }, "reaction_10648553": { "compartment": "compartment_7660", "id": "reaction_10648553", "reactome": "R-CEL-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10648537" ], "products": [ "species_10648551" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "Q95PZ4", "WBGene00013441", "P53016", "WBGene00004340", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "P34429", "WBGene00018409", "Q93456", "WBGene00008665", "Q19366", "WBGene00008722", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648672": { "compartment": "compartment_7660", "id": "reaction_10648672", "reactome": "R-CEL-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648669" ], "products": [ "species_10648537" ], "modifiers": [ [ "species_10648669", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q93456", "WBGene00008665", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q95Y97", "WBGene00019767", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320" ] }, "reaction_10663517": { "compartment": "compartment_876", "id": "reaction_10663517", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_10636623" ], "products": [ "species_10663515" ], "modifiers": [], "additional_components": [ "WBGene00004854", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "G5EFX6", "WBGene00004854" ] }, "reaction_10657351": { "compartment": "compartment_20699", "id": "reaction_10657351", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10657483": { "compartment": "compartment_12045", "id": "reaction_10657483", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657445", "species_113592" ], "products": [ "species_29370", "species_10657463", "species_10656090", "species_10657432" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10657481", "catalyst" ] ], "additional_components": [ "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "V6CJ04", "WBGene00016611", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10657547": { "compartment": "compartment_12045", "id": "reaction_10657547", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657543", "species_10657475" ], "products": [ "species_10657545" ], "modifiers": [], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656574": { "compartment": "compartment_20699", "id": "reaction_10656574", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656558", "species_10655931", "species_10656284", "species_10656560", "species_10656570" ], "products": [ "species_10656572" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "WBGene00018853", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "P90904", "WBGene00010500", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195" ] }, "reaction_10656616": { "compartment": "compartment_12045", "id": "reaction_10656616", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656614" ], "products": [ "species_10656607" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657436": { "compartment": "compartment_20699", "id": "reaction_10657436", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657419", "species_10657417", "species_10657432" ], "products": [ "species_10657434" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10656702": { "compartment": "compartment_12045", "id": "reaction_10656702", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656700" ], "products": [ "species_10649098", "species_10656652", "species_10656614", "species_10655913", "species_10656698" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q9N598", "WBGene00022460", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "Q19642", "WBGene00017643", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P90841", "WBGene00008990", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "species_29420", "Q9UAQ6", "WBGene00004266", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q18864", "WBGene00004788", "O17528", "WBGene00004766", "Q20546", "WBGene00009829", "P48583", "WBGene00001331", "Q09473", "WBGene00016195" ] }, "reaction_10657447": { "compartment": "compartment_20699", "id": "reaction_10657447", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657434", "species_10657443" ], "products": [ "species_10657445", "species_10657441" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9NDC9", "WBGene00003047", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q22782", "WBGene00004270", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "V6CJ04", "WBGene00016611", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "P34213", "WBGene00004269", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "WBGene00003047" ] }, "reaction_10656554": { "compartment": "compartment_20699", "id": "reaction_10656554", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656258", "species_10655846" ], "products": [ "species_10656552" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438" ] }, "reaction_10656610": { "compartment": "compartment_12045", "id": "reaction_10656610", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656607" ], "products": [ "species_10649229", "species_10656598", "species_10656603", "species_10649213", "species_10612598", "species_10656593", "species_29372" ], "modifiers": [ [ "species_10656607", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00020425", "WBGene00022460", "Q94392", "WBGene00003818", "WBGene00018853", "WBGene00018239", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q9N598", "WBGene00022460", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818" ] }, "reaction_10657550": { "compartment": "compartment_12045", "id": "reaction_10657550", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10657545" ], "products": [ "species_10657481", "species_29420" ], "modifiers": [ [ "species_10657545", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "Q8MXS1", "WBGene00004277", "species_29438", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317", "species_29420", "Q8MXS1", "WBGene00004277", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10656618": { "compartment": "compartment_432051", "id": "reaction_10656618", "reactome": "R-CEL-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628218", "species_10656588" ], "products": [ "species_10656612" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "O44738", "WBGene00019003", "Q9UAQ6", "WBGene00004266", "O17528", "WBGene00004766", "species_29438", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q18864", "WBGene00004788", "Q22498", "WBGene00011775", "Q20546", "WBGene00009829", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "Q20546", "WBGene00009829", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "O44738", "WBGene00019003", "H2L2E8", "WBGene00006528", "O17528", "WBGene00004766", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P48583", "WBGene00001331", "P12456", "WBGene00003171", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "P34690", "WBGene00006529", "Q18864", "WBGene00004788", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "Q94241", "WBGene00018853" ] }, "reaction_10647110": { "compartment": "compartment_876", "id": "reaction_10647110", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647066" ], "products": [ "species_29370", "species_10647091" ], "modifiers": [ [ "species_10647066", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647108", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647102": { "compartment": "compartment_876", "id": "reaction_10647102", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647091" ], "products": [ "species_29370", "species_10647093" ], "modifiers": [ [ "species_10647091", "catalyst" ], [ "species_10647098", "inhibitor" ], [ "species_10647096", "inhibitor" ], [ "species_10647100", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10665556": { "compartment": "compartment_876", "id": "reaction_10665556", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10647066" ], "products": [ "species_10647098" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "LigandDisplayForward?ligandId=9909", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "LigandDisplayForward?ligandId=6495", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "pubchem.compound:16719221", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647155": { "compartment": "compartment_74700", "id": "reaction_10647155", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647145", "species_10647147", "species_10618746", "species_10647064" ], "products": [ "species_10647149" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10665558": { "compartment": "compartment_876", "id": "reaction_10665558", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647091", "species_9657570" ], "products": [ "species_10647100" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9974", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8056", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647113": { "compartment": "compartment_876", "id": "reaction_10647113", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647093" ], "products": [ "species_10647054", "species_10647068", "species_10618752", "species_10647089" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186" ] }, "reaction_10665560": { "compartment": "compartment_876", "id": "reaction_10665560", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657574", "species_10647091" ], "products": [ "species_10647096" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "LigandDisplayForward?ligandId=7935", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=5676", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "LigandDisplayForward?ligandId=5665", "Q27874", "WBGene00003930", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647185": { "compartment": "compartment_20699", "id": "reaction_10647185", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647178" ], "products": [ "species_10647182", "species_29370" ], "modifiers": [ [ "species_10647178", "catalyst" ] ], "additional_components": [ "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10647077": { "compartment": "compartment_876", "id": "reaction_10647077", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647054", "species_10647030", "species_10618746", "species_10647064" ], "products": [ "species_10647066" ], "modifiers": [ [ "species_10647075", "inhibitor" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "G5EDA5", "WBGene00002240", "species_74016", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P19826", "WBGene00000942", "species_29438", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10647180": { "compartment": "compartment_20699", "id": "reaction_10647180", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10647089", "species_10647176" ], "products": [ "species_10647178" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10664", "WBGene00003186", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "U4PDY6", "WBGene00019665" ] }, "reaction_10665564": { "compartment": "compartment_876", "id": "reaction_10665564", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10647093" ], "products": [ "species_10665562" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064", "G5EE56", "WBGene00005077", "G5EEW9", "WBGene00000564", "O17772", "WBGene00003980", "P41932", "WBGene00003920", "U4PDY6", "WBGene00019665", "Q9XXE9", "WBGene00016769", "G5EFD2", "WBGene00002239", "P51485", "WBGene00000195", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "LigandDisplayForward?ligandId=9229", "Q18246", "WBGene00004307", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "G5EDA5", "WBGene00002240", "species_74016", "P19826", "WBGene00000942", "species_29438", "Q27874", "WBGene00003930", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P34446", "WBGene00003929", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10647153": { "compartment": "compartment_74700", "id": "reaction_10647153", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647149" ], "products": [ "species_29370", "species_10647151" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402", "Q19986", "WBGene00018014", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "U4PDY6", "WBGene00019665", "Q8WQG5", "WBGene00007390", "Q9N2U6", "WBGene00022402" ] }, "reaction_10630903": { "compartment": "compartment_70616", "id": "reaction_10630903", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10630925": { "compartment": "compartment_12045", "id": "reaction_10630925", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10630895": { "compartment": "compartment_12045", "id": "reaction_10630895", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498740", "species_1500578" ], "products": [ "species_76194", "species_1483256" ], "modifiers": [ [ "species_10630892", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10631927": { "compartment": "compartment_984", "id": "reaction_10631927", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602402", "species_109276" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10630962": { "compartment": "compartment_70616", "id": "reaction_10630962", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_1524042", "species_29374" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10657697": { "compartment": "compartment_70101", "id": "reaction_10657697", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647007", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947", "Q9XWK4", "WBGene00013202" ] }, "reaction_10657694": { "compartment": "compartment_70101", "id": "reaction_10657694", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647009", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10642565": { "compartment": "compartment_13231", "id": "reaction_10642565", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10641096", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10642747": { "compartment": "compartment_7660", "id": "reaction_10642747", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642729", "species_29358" ], "products": [ "species_113582", "species_10642745" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q21443", "WBGene00003052", "Q21443", "WBGene00003052", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10642573": { "compartment": "compartment_13231", "id": "reaction_10642573", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29496", "species_10642567", "species_5221124" ], "products": [ "species_10642571" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10642190": { "compartment": "compartment_7660", "id": "reaction_10642190", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641096" ], "products": [ "species_113582", "species_10641090" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10641115": { "compartment": "compartment_13231", "id": "reaction_10641115", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10641090" ], "products": [ "species_113550", "species_10641096" ], "modifiers": [ [ "species_10641112", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q9XXN3", "WBGene00011828", "Q20432", "WBGene00018474" ] }, "reaction_10638146": { "compartment": "compartment_70101", "id": "reaction_10638146", "reactome": "R-CEL-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602774" ], "products": [ "species_10638130", "species_29370" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10651289": { "compartment": "compartment_70101", "id": "reaction_10651289", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651285", "species_10617017" ], "products": [ "species_10651287" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488" ] }, "reaction_10651323": { "compartment": "compartment_876", "id": "reaction_10651323", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651319", "species_10612288" ], "products": [ "species_10651321" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006", "WBGene00010664", "I2HAJ6", "WBGene00007799", "A0A1T5HV05", "WBGene00020970", "B7WN72", "WBGene00006444", "Q9XTG1", "WBGene00006412", "Q9XUT0", "WBGene00010664", "Q20826", "WBGene00018878", "G5ECY0", "WBGene00001006" ] }, "reaction_10617553": { "compartment": "compartment_70101", "id": "reaction_10617553", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617549", "species_10617493" ], "products": [ "species_10617551" ], "modifiers": [], "additional_components": [ "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q95Y26", "WBGene00021507", "O17889", "WBGene00044348", "G5EGU2", "WBGene00008663", "Q21049", "WBGene00006364", "Q95XL1", "WBGene00044348", "P28192", "WBGene00010558", "Q9BMN8", "WBGene00004215", "Q94071", "WBGene00011904", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "O01736", "WBGene00044348", "G5EGA9", "WBGene00004748" ] }, "reaction_10651237": { "compartment": "compartment_876", "id": "reaction_10651237", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651191", "species_10651233" ], "products": [ "species_10651235" ], "modifiers": [], "additional_components": [ "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10651327": { "compartment": "compartment_876", "id": "reaction_10651327", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651287", "species_10651235" ], "products": [ "species_10651325" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878", "H2KZV9", "WBGene00001489", "P54936", "WBGene00002991", "I2HAJ6", "WBGene00007799", "G5EEG8", "WBGene00001488", "Q9XTG1", "WBGene00006412", "Q20826", "WBGene00018878" ] }, "reaction_10657531": { "compartment": "compartment_876", "id": "reaction_10657531", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10657527" ], "products": [ "species_10657529" ], "modifiers": [], "additional_components": [ "WBGene00001006", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "G5ECY0", "WBGene00001006" ] }, "reaction_10644074": { "compartment": "compartment_5460", "id": "reaction_10644074", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_10644070", "species_10644061" ], "products": [ "species_10644072" ], "modifiers": [], "additional_components": [ "Q95QC2", "WBGene00019838", "O44568", "WBGene00020993", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "O44568", "WBGene00020993", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644103": { "compartment": "compartment_5460", "id": "reaction_10644103", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644078", "species_10644092" ], "products": [ "species_10644101" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "WBGene00020625", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644080": { "compartment": "compartment_5460", "id": "reaction_10644080", "reactome": "R-CEL-5419271", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644072" ], "products": [ "species_10644078", "species_10644070", "species_113548", "species_113525", "species_5419287" ], "modifiers": [], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "O44568", "WBGene00020993", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q95QC2", "WBGene00019838", "O44568", "WBGene00020993" ] }, "reaction_10644099": { "compartment": "compartment_5460", "id": "reaction_10644099", "reactome": "R-CEL-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644094" ], "products": [ "species_10643799", "species_113548", "species_10644096", "species_10644092", "species_10644042" ], "modifiers": [ [ "species_10644094", "catalyst" ] ], "additional_components": [ "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q95Y73", "WBGene00022491", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "Q11189", "WBGene00015487", "G5EC67", "WBGene00013210", "Q22470", "WBGene00011759", "P49391", "WBGene00011334", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9N361", "WBGene00021920", "Q9U3Q0", "WBGene00007564", "Q9GYI2", "WBGene00017924", "G5ECC9", "WBGene00010766", "Q93425", "WBGene00008452", "Q9NEI6", "WBGene00012697", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "O61818", "WBGene00044321", "P34748", "WBGene00014224", "Q9XTY5", "WBGene00011391", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "Q9NAP9", "WBGene00010624", "G5EFC8", "WBGene00000933", "Q23155", "WBGene00012244", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q19685", "WBGene00009013", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "species_29420", "Q95Y73", "WBGene00022491", "WBGene00020625", "P90915", "WBGene00010616", "Q9TZ90", "WBGene00018793", "Q95QC2", "WBGene00019838", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q21939", "WBGene00011247", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "Q9GYS9", "WBGene00020348", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "O17839", "WBGene00009128", "Q9NAG2", "WBGene00012992", "Q9N3F3", "WBGene00021829", "Q95X39", "WBGene00015025", "P90993", "WBGene00015185", "Q9XX18", "WBGene00012645", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q04907", "WBGene00016249", "Q9UA63", "WBGene00021021", "Q7YWY8", "WBGene00010783", "O18180", "WBGene00012361", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P34264", "WBGene00015133", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q21083", "WBGene00010458", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "Q4W5T0", "WBGene00044344", "Q7YX52", "WBGene00008459", "Q9BL86", "WBGene00021327", "Q9TYJ8", "WBGene00022045", "O45110", "WBGene00018932", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", 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"WBGene00007215", "Q2L6V2", "WBGene00015092", "P91478", "WBGene00020625", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q95Y73", "WBGene00022491", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10644059": { "compartment": "compartment_5460", "id": "reaction_10644059", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644055", "species_10644048" ], "products": [ "species_10644057" ], "modifiers": [], "additional_components": [ "Q9XV52", "WBGene00009246", "species_29438", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487", "Q9TZ90", "WBGene00018793", "C0VXV6", "WBGene00021935", "P91353", "WBGene00019076", "Q9BPN6", "WBGene00022373", "Q95Q11", "WBGene00013324", "Q09523", "WBGene00008456", "G5EC67", "WBGene00013210", "O44159", "WBGene00016989", "Q9GYS9", "WBGene00020348", "Q9XWV5", "WBGene00012556", "O61791", "WBGene00020037", "Q9U3Q0", "WBGene00007564", "Q21454", "WBGene00010812", "Q95QL2", "WBGene00008769", "G5ECC9", "WBGene00010766", "O17839", "WBGene00009128", "Q93425", "WBGene00008452", "Q9NAG2", "WBGene00012992", "P90993", "WBGene00015185", "P34384", "WBGene00008514", "Q6A575", "WBGene00023422", "Q22438", "WBGene00011740", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "A0A1N7SYX2", "WBGene00003066", "Q9UA63", "WBGene00021021", "O17004", "WBGene00020718", "Q21601", "WBGene00010905", "Q7YWY8", "WBGene00010783", "Q95Y71", "WBGene00022493", "O61818", "WBGene00044321", "P34264", "WBGene00015133", "Q9XTY5", "WBGene00011391", "Q21083", "WBGene00010458", "Q9NAP9", "WBGene00010624", "Q9BL86", "WBGene00021327", "Q19685", "WBGene00009013", "O45110", "WBGene00018932", "P90915", "WBGene00010616", "Q95QC2", "WBGene00019838", "Q21939", "WBGene00011247", "Q11189", "WBGene00015487", "O02207", "WBGene00007215", "Q2L6V2", "WBGene00015092", "Q22470", "WBGene00011759", "Q95Y83", "WBGene00022470", "Q22623", "WBGene00011883", "P49391", "WBGene00011334", "Q9N361", "WBGene00021920", "Q9GYI2", "WBGene00017924", "Q9N3F3", "WBGene00021829", "Q9NEI6", "WBGene00012697", "Q95X39", "WBGene00015025", "Q9XX18", "WBGene00012645", "P34388", "WBGene00017319", "Q9N584", "WBGene00002804", "Q04907", "WBGene00016249", "Q9XV52", "WBGene00009246", "O18180", "WBGene00012361", "Q22140", "WBGene00011412", "P34748", "WBGene00014224", "species_29438", "O76606", "WBGene00020796", "P34378", "WBGene00017044", "Q22483", "WBGene00020499", "Q10129", "WBGene00018961", "Q95QS3", "WBGene00016412", "O02220", "WBGene00007712", "P49404", "WBGene00016142", "O18199", "WBGene00013004", "G5EFC8", "WBGene00000933", "Q4W5T0", "WBGene00044344", "Q23155", "WBGene00012244", "Q7YX52", "WBGene00008459", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "Q9TYJ8", "WBGene00022045", "Q9XWP0", "WBGene00012830", "Q688C0", "WBGene00023487" ] }, "reaction_10630939": { "compartment": "compartment_12045", "id": "reaction_10630939", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10659187": { "compartment": "compartment_12045", "id": "reaction_10659187", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10659184", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10630965": { "compartment": "compartment_12045", "id": "reaction_10630965", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10630936", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631930": { "compartment": "compartment_984", "id": "reaction_10631930", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10663355": { "compartment": "compartment_5460", "id": "reaction_10663355", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663347" ], "products": [], "modifiers": [ [ "species_10663352", "catalyst" ] ], "additional_components": [ "Q9BKS0", "WBGene00022336", "Q8I7J4", "WBGene00000762", "Q9XWJ5", "WBGene00013094", "P46561", "WBGene00000229", "Q8I4K2", "WBGene00009334", "WBGene00011679" ] }, "reaction_10625828": { "compartment": "compartment_876", "id": "reaction_10625828", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "species_71185", "CHEBI:36144", "species_71185", "CHEBI:36144", "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10629240": { "compartment": "compartment_70101", "id": "reaction_10629240", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_1250243" ], "products": [ "species_10601705" ], "modifiers": [], "additional_components": [ "WBGene00020917", "WBGene00020917" ] }, "reaction_10629211": { "compartment": "compartment_70101", "id": "reaction_10629211", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629198" ], "products": [ "species_29370", "species_10629208" ], "modifiers": [ [ "species_10622456", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004758" ] }, "reaction_10634116": { "compartment": "compartment_70101", "id": "reaction_10634116", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634100" ], "products": [ "species_10634109" ], "modifiers": [ [ "species_10634114", "inhibitor" ] ], "additional_components": [ "P41990", "WBGene00000168", "P41990", "WBGene00000168", "WBGene00004766" ] }, "reaction_10664120": { "compartment": "compartment_7660", "id": "reaction_10664120", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10664115" ], "products": [ "species_113582", "species_10664115" ], "modifiers": [ [ "species_10664117", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10629322": { "compartment": "compartment_70101", "id": "reaction_10629322", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629255" ], "products": [ "species_10629265" ], "modifiers": [ [ "species_10629319", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "O02100", "WBGene00001985", "O45876", "WBGene00000147", "Q9U357", "WBGene00003975", "Q23316", "WBGene00000148", "Q01608", "WBGene00004958", "P52166", "WBGene00004769" ] }, "reaction_10629346": { "compartment": "compartment_70101", "id": "reaction_10629346", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629341", "species_10597908" ], "products": [ "species_10629343" ], "modifiers": [ [ "species_10629341", "catalyst" ] ], "additional_components": [ "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629372": { "compartment": "compartment_70101", "id": "reaction_10629372", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10629265" ], "products": [ "species_10629364" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629357": { "compartment": "compartment_70101", "id": "reaction_10629357", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10629265" ], "products": [ "species_10629355" ], "modifiers": [], "additional_components": [ "WBGene00017131", "P24348", "WBGene00002299", "Q95QN9", "WBGene00017131", "P24348", "WBGene00002299" ] }, "reaction_10629396": { "compartment": "compartment_70101", "id": "reaction_10629396", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629384" ], "products": [ "species_10629394" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10629370": { "compartment": "compartment_70101", "id": "reaction_10629370", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629364" ], "products": [ "species_10629368" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10629398": { "compartment": "compartment_70101", "id": "reaction_10629398", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10629382" ], "products": [ "species_10629384" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "Q20977", "WBGene00010251" ] }, "reaction_10664835": { "compartment": "compartment_876", "id": "reaction_10664835", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265", "species_10615184" ], "products": [ "species_10629334" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00005077", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10629348": { "compartment": "compartment_876", "id": "reaction_10629348", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627496", "species_10629339" ], "products": [ "species_10629341" ], "modifiers": [], "additional_components": [ "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10629410": { "compartment": "compartment_70101", "id": "reaction_10629410", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629408" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10634331": { "compartment": "compartment_70101", "id": "reaction_10634331", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634324", "species_10597908" ], "products": [ "species_10634328" ], "modifiers": [ [ "species_10634324", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10629336": { "compartment": "compartment_70101", "id": "reaction_10629336", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629265" ], "products": [ "species_10629332" ], "modifiers": [ [ "species_10629334", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299" ] }, "reaction_10634326": { "compartment": "compartment_70101", "id": "reaction_10634326", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627458", "species_10629259" ], "products": [ "species_10634324" ], "modifiers": [], "additional_components": [ "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10605846": { "compartment": "compartment_70101", "id": "reaction_10605846", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840" ], "products": [ "species_10605844" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10605848": { "compartment": "compartment_70101", "id": "reaction_10605848", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605835", "species_10605840", "species_10605825", "species_10605830" ], "products": [ "species_10605842" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q21776", "WBGene00000275", "O02053", "WBGene00004721", "WBGene00013209", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "O02053", "WBGene00004721", "Q09373", "WBGene00001511" ] }, "reaction_10607997": { "compartment": "compartment_7660", "id": "reaction_10607997", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607992" ], "products": [ "species_113582", "species_10607994" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10605577": { "compartment": "compartment_70101", "id": "reaction_10605577", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10605570" ], "products": [ "species_10605572" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619745": { "compartment": "compartment_876", "id": "reaction_10619745", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619741", "species_114519" ], "products": [ "species_10619743" ], "modifiers": [], "additional_components": [ "P34586", "WBGene00006614", "G5EF09", "WBGene00004976", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10619520": { "compartment": "compartment_70101", "id": "reaction_10619520", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610919", "species_114519" ], "products": [ "species_10619518" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10649353": { "compartment": "compartment_876", "id": "reaction_10649353", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694509", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10649350", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10605575": { "compartment": "compartment_114521", "id": "reaction_10605575", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10605572", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016" ] }, "reaction_10619788": { "compartment": "compartment_70101", "id": "reaction_10619788", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10619785", "catalyst" ] ], "additional_components": [ "H2KZC9", "WBGene00006483", "Q03603", "WBGene00000960", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958", "Q10024", "WBGene00019428" ] }, "reaction_10619647": { "compartment": "compartment_876", "id": "reaction_10619647", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10619644", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10650309": { "compartment": "compartment_70101", "id": "reaction_10650309", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788291", "species_29356" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10650306", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_109496" ] }, "reaction_10602217": { "compartment": "compartment_70101", "id": "reaction_10602217", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q23588", "WBGene00022817" ] }, "reaction_10601699": { "compartment": "compartment_70101", "id": "reaction_10601699", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10601696", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10662627": { "compartment": "compartment_70101", "id": "reaction_10662627", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10662624", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "WBGene00008948" ] }, "reaction_10601683": { "compartment": "compartment_70101", "id": "reaction_10601683", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10601680", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_216667", "Q20628", "WBGene00000392" ] }, "reaction_10601663": { "compartment": "compartment_70101", "id": "reaction_10601663", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10601660", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604531": { "compartment": "compartment_70101", "id": "reaction_10604531", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10604528", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_727810", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10604921": { "compartment": "compartment_70101", "id": "reaction_10604921", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604918", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10661713": { "compartment": "compartment_70101", "id": "reaction_10661713", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10604862" ], "products": [ "species_10604864" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389" ] }, "reaction_10621546": { "compartment": "compartment_70101", "id": "reaction_10621546", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10621538" ], "products": [ "species_113582", "species_10621543" ], "modifiers": [ [ "species_10621538", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604963": { "compartment": "compartment_876", "id": "reaction_10604963", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604936" ], "products": [ "species_29370", "species_10604960" ], "modifiers": [ [ "species_10604954", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604900": { "compartment": "compartment_876", "id": "reaction_10604900", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10604895", "catalyst" ], [ "species_10604898", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10604956": { "compartment": "compartment_70101", "id": "reaction_10604956", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604898" ], "products": [ "species_10604938" ], "modifiers": [ [ "species_10604954", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "Q09639", "WBGene00001709", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P90980", "WBGene00004033", "species_74016", "P34722", "WBGene00006599" ] }, "reaction_10604868": { "compartment": "compartment_70101", "id": "reaction_10604868", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604864" ], "products": [ "species_10604866", "species_10604860" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10604923": { "compartment": "compartment_70101", "id": "reaction_10604923", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604918" ], "products": [ "species_10604918" ], "modifiers": [ [ "species_10604898", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10651257": { "compartment": "compartment_70101", "id": "reaction_10651257", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10651245" ], "products": [ "species_29370", "species_10651255" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655489": { "compartment": "compartment_70101", "id": "reaction_10655489", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655483" ], "products": [ "species_10655487" ], "modifiers": [], "additional_components": [ "WBGene00009647", "WBGene00009647" ] }, "reaction_10645807": { "compartment": "compartment_70101", "id": "reaction_10645807", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645791", "species_10645799" ], "products": [ "species_10645805" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598469": { "compartment": "compartment_70101", "id": "reaction_10598469", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10598466", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10599754": { "compartment": "compartment_70101", "id": "reaction_10599754", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10599751", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10651416": { "compartment": "compartment_7660", "id": "reaction_10651416", "reactome": "R-CEL-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651410", "species_29358" ], "products": [ "species_113582", "species_10651414" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00003150", "WBGene00003150", "WBGene00000227" ] }, "reaction_10639605": { "compartment": "compartment_70101", "id": "reaction_10639605", "reactome": "R-CEL-3341277", "name": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10636065", "catalyst" ] ], "additional_components": [ "Q93204", "WBGene00007516" ] }, "reaction_10655691": { "compartment": "compartment_70101", "id": "reaction_10655691", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655683" ], "products": [ "species_10655685" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10645811": { "compartment": "compartment_70101", "id": "reaction_10645811", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617093", "species_10645799" ], "products": [ "species_10645809" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "WBGene00022279", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q9N4D6", "WBGene00022279", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10655536": { "compartment": "compartment_876", "id": "reaction_10655536", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655527", "species_10655532" ], "products": [ "species_10655534" ], "modifiers": [], "additional_components": [ "WBGene00019778", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10662505": { "compartment": "compartment_7660", "id": "reaction_10662505", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662497" ], "products": [ "species_10662503" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10662495": { "compartment": "compartment_7660", "id": "reaction_10662495", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491" ], "products": [ "species_10662493" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10655485": { "compartment": "compartment_7660", "id": "reaction_10655485", "reactome": "R-CEL-6800490", "name": "ATM phosphorylates PIDD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10655480" ], "products": [ "species_113582", "species_10655483" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00009647", "WBGene00009647", "WBGene00000227" ] }, "reaction_10598826": { "compartment": "compartment_5460", "id": "reaction_10598826", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113522" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10598823", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q93650", "WBGene00009271", "Q19013", "WBGene00008435" ] }, "reaction_10660349": { "compartment": "compartment_7660", "id": "reaction_10660349", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625955", "species_10660342" ], "products": [ "species_10660347" ], "modifiers": [], "additional_components": [ "WBGene00022448", "Q9BL73", "WBGene00004088", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10651355": { "compartment": "compartment_7660", "id": "reaction_10651355", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651335", "species_10651264" ], "products": [ "species_10651337" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655689": { "compartment": "compartment_70101", "id": "reaction_10655689", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655677", "species_10655685" ], "products": [ "species_10655687" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "P41932", "WBGene00003920", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10645794": { "compartment": "compartment_70101", "id": "reaction_10645794", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10639622" ], "products": [ "species_10645791", "species_29356" ], "modifiers": [ [ "species_10639622", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10598605": { "compartment": "compartment_70101", "id": "reaction_10598605", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10598600", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10651266": { "compartment": "compartment_7660", "id": "reaction_10651266", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651262" ], "products": [ "species_10651264" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10660345": { "compartment": "compartment_7660", "id": "reaction_10660345", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10660331" ], "products": [ "species_113582", "species_10660342" ], "modifiers": [ [ "species_10622470", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10651272": { "compartment": "compartment_7660", "id": "reaction_10651272", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605098", "species_10651268" ], "products": [ "species_10651270" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135" ] }, "reaction_10662501": { "compartment": "compartment_7660", "id": "reaction_10662501", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662491", "species_10662497" ], "products": [ "species_10662499" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10639631": { "compartment": "compartment_70101", "id": "reaction_10639631", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10601707" ], "products": [ "species_29356", "species_10601705" ], "modifiers": [ [ "species_10639628", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10651247": { "compartment": "compartment_70101", "id": "reaction_10651247", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637490" ], "products": [ "species_29370", "species_10651245" ], "modifiers": [ [ "species_10611000", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "G4S4W1", "WBGene00016980", "Q2PJ68", "WBGene00004789", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583" ] }, "reaction_10655545": { "compartment": "compartment_70101", "id": "reaction_10655545", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655534", "species_10655541" ], "products": [ "species_10655543" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10617109": { "compartment": "compartment_70101", "id": "reaction_10617109", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106", "species_29372" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10651353": { "compartment": "compartment_7660", "id": "reaction_10651353", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10651337" ], "products": [ "species_113582", "species_10651350" ], "modifiers": [ [ "species_10651337", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "P46551", "WBGene00007135", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q9BKS1", "WBGene00001236", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10655741": { "compartment": "compartment_7660", "id": "reaction_10655741", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605168", "species_10655737" ], "products": [ "species_10655739" ], "modifiers": [], "additional_components": [ "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P41848", "WBGene00001974", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849" ] }, "reaction_10614736": { "compartment": "compartment_984", "id": "reaction_10614736", "reactome": "R-CEL-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10614732" ], "products": [ "species_10614734" ], "modifiers": [], "additional_components": [ "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "species_265479", "Q19127", "WBGene00003561", "P34389", "WBGene00003562" ] }, "reaction_10661657": { "compartment": "compartment_70101", "id": "reaction_10661657", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661653" ], "products": [ "species_10661655" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661663": { "compartment": "compartment_70101", "id": "reaction_10661663", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559", "species_10661617" ], "products": [ "species_10661653" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10617891": { "compartment": "compartment_984", "id": "reaction_10617891", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10617885": { "compartment": "compartment_984", "id": "reaction_10617885", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616519" ], "products": [ "species_10616523" ], "modifiers": [ [ "species_10617883", "catalyst" ], [ "species_10617881", "inhibitor" ] ], "additional_components": [ "species_374935", "species_209794", "WBGene00008890", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=483", "LigandDisplayForward?ligandId=485", "LigandDisplayForward?ligandId=124", "LigandDisplayForward?ligandId=480", "LigandDisplayForward?ligandId=3469", "LigandDisplayForward?ligandId=481", "G5EBX8", "WBGene00008890", "LigandDisplayForward?ligandId=7302", "LigandDisplayForward?ligandId=503", "LigandDisplayForward?ligandId=7170" ] }, "reaction_10656795": { "compartment": "compartment_70101", "id": "reaction_10656795", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610899", "species_29356" ], "products": [ "species_29372", "species_10617854" ], "modifiers": [ [ "species_10656790", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10636518": { "compartment": "compartment_70101", "id": "reaction_10636518", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10636515", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "species_179838", "Q10656", "WBGene00001184", "Q45FX5", "WBGene00006887", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "O18008", "WBGene00021745" ] }, "reaction_10633249": { "compartment": "compartment_876", "id": "reaction_10633249", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633061": { "compartment": "compartment_876", "id": "reaction_10633061", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10633058", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10658313": { "compartment": "compartment_70101", "id": "reaction_10658313", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610622", "species_113592" ], "products": [ "species_29370", "species_10658301" ], "modifiers": [ [ "species_10658310", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [ "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EE56", "WBGene00005077", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10642713": { "compartment": "compartment_70101", "id": "reaction_10642713", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612004", "species_113592" ], "products": [ "species_29370", "species_10610661" ], "modifiers": [ [ "species_10612004", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "O62090", "WBGene00004202", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10661437": { "compartment": "compartment_7660", "id": "reaction_10661437", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661433", "species_10639314" ], "products": [ "species_10661435" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10635829": { "compartment": "compartment_70101", "id": "reaction_10635829", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613633", "species_10610677" ], "products": [ "species_10635827" ], "modifiers": [], "additional_components": [ "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610705": { "compartment": "compartment_70101", "id": "reaction_10610705", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610692", "species_113592" ], "products": [ "species_10610672", "species_29370" ], "modifiers": [ [ "species_10610692", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10635835": { "compartment": "compartment_70101", "id": "reaction_10635835", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635831" ], "products": [ "species_10613633", "species_10635833", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10635837": { "compartment": "compartment_70101", "id": "reaction_10635837", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635827", "species_10597908" ], "products": [ "species_10635831" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00006727", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5ECU1", "WBGene00004807", "G5EFL7", "WBGene00010555", "P0CG71", "WBGene00006727", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10641384": { "compartment": "compartment_7660", "id": "reaction_10641384", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639298" ], "products": [ "species_10639314" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10610714": { "compartment": "compartment_70101", "id": "reaction_10610714", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610709", "species_113592" ], "products": [ "species_29370", "species_10610699" ], "modifiers": [ [ "species_10610709", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610684": { "compartment": "compartment_70101", "id": "reaction_10610684", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610677" ], "products": [ "species_10610677" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610702": { "compartment": "compartment_70101", "id": "reaction_10610702", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610699" ], "products": [ "species_29370", "species_10610688" ], "modifiers": [ [ "species_10610699", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610711": { "compartment": "compartment_70101", "id": "reaction_10610711", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610661", "species_10610707" ], "products": [ "species_10610709" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "WBGene00001979", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10610695": { "compartment": "compartment_70101", "id": "reaction_10610695", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610688" ], "products": [ "species_29370", "species_10610692" ], "modifiers": [ [ "species_10610688", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10643089": { "compartment": "compartment_7660", "id": "reaction_10643089", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638387", "species_10639287" ], "products": [ "species_10643087" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10610682": { "compartment": "compartment_70101", "id": "reaction_10610682", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610672", "species_113592" ], "products": [ "species_29370", "species_10610677" ], "modifiers": [ [ "species_10610672", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202", "Q21227", "WBGene00000156", "Q09595", "WBGene00010991", "G5EGK8", "WBGene00002363", "O44326", "WBGene00001979", "Q93372", "WBGene00010991", "Q21204", "WBGene00010555", "G5EFL7", "WBGene00010555", "A9UJN4", "WBGene00007554", "O62090", "WBGene00004202", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "O17828", "WBGene00008995", "Q3LRZ3", "WBGene00010497", "Q9U2Q9", "WBGene00001746", "P42168", "WBGene00002202" ] }, "reaction_10654727": { "compartment": "compartment_70101", "id": "reaction_10654727", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10654724", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10598546": { "compartment": "compartment_70101", "id": "reaction_10598546", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29360", "species_29372" ], "products": [ "species_70106", "species_73473", "species_29800" ], "modifiers": [ [ "species_10598543", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17331", "WBGene00001686", "P17329", "WBGene00001684", "P17330", "WBGene00001685" ] }, "reaction_10599692": { "compartment": "compartment_70101", "id": "reaction_10599692", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29492", "species_29356" ], "modifiers": [ [ "species_10598654", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_109496" ] }, "reaction_10599874": { "compartment": "compartment_70101", "id": "reaction_10599874", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10598638", "catalyst" ] ], "additional_components": [ "P91427", "WBGene00020185", "species_109496" ] }, "reaction_10649423": { "compartment": "compartment_12045", "id": "reaction_10649423", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10649420", "catalyst" ] ], "additional_components": [ "Q86S40", "WBGene00016810", "species_109496" ] }, "reaction_10598593": { "compartment": "compartment_70101", "id": "reaction_10598593", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10598590", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10598507": { "compartment": "compartment_70101", "id": "reaction_10598507", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10598504", "catalyst" ] ], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599870": { "compartment": "compartment_70101", "id": "reaction_10599870", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10599867", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10662663": { "compartment": "compartment_70101", "id": "reaction_10662663", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10598402", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10599719": { "compartment": "compartment_70101", "id": "reaction_10599719", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10599716", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001", "species_74126", "species_109496" ] }, "reaction_10598391": { "compartment": "compartment_70101", "id": "reaction_10598391", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598388", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295" ] }, "reaction_10598556": { "compartment": "compartment_70101", "id": "reaction_10598556", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10598553", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10607710": { "compartment": "compartment_13231", "id": "reaction_10607710", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607708" ], "products": [ "species_10598486" ], "modifiers": [], "additional_components": [ "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10599566", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10625184": { "compartment": "compartment_5460", "id": "reaction_10625184", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_880046", "species_113526" ], "products": [ "species_113536", "species_29362", "species_113529" ], "modifiers": [ [ "species_10625181", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10625666": { "compartment": "compartment_5460", "id": "reaction_10625666", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10625663", "catalyst" ] ], "additional_components": [ "Q21217", "WBGene00001794", "CHEBI:33739" ] }, "reaction_10641688": { "compartment": "compartment_7660", "id": "reaction_10641688", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_77087" ], "products": [ "species_10641673", "species_77502" ], "modifiers": [ [ "species_10641685", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10642433": { "compartment": "compartment_7660", "id": "reaction_10642433", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642398", "species_77087" ], "products": [ "species_10642431", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00013766" ] }, "reaction_10646433": { "compartment": "compartment_7660", "id": "reaction_10646433", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642265", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10646024": { "compartment": "compartment_7660", "id": "reaction_10646024", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646006", "species_77087" ], "products": [ "species_77502", "species_10646022" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10638598": { "compartment": "compartment_7660", "id": "reaction_10638598", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586" ], "products": [ "species_29478", "species_10638588" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10642756": { "compartment": "compartment_7660", "id": "reaction_10642756", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_77087" ], "products": [ "species_10642749", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ], [ "species_10642358", "inhibitor" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10642562": { "compartment": "compartment_7660", "id": "reaction_10642562", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10642554", "species_77502" ], "modifiers": [ [ "species_10642559", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012298" ] }, "reaction_10641713": { "compartment": "compartment_7660", "id": "reaction_10641713", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10641526", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646014": { "compartment": "compartment_7660", "id": "reaction_10646014", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645998", "species_77087" ], "products": [ "species_10646006", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10641594": { "compartment": "compartment_7660", "id": "reaction_10641594", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10638586", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10640230": { "compartment": "compartment_7660", "id": "reaction_10640230", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640227", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "Q18919", "WBGene00005006", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "Q95Y41", "WBGene00022278" ] }, "reaction_10641550": { "compartment": "compartment_7660", "id": "reaction_10641550", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10639479": { "compartment": "compartment_7660", "id": "reaction_10639479", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639441", "species_113560" ], "products": [ "species_10639476", "species_2485002" ], "modifiers": [ [ "species_10607230", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10646440": { "compartment": "compartment_7660", "id": "reaction_10646440", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10642265" ], "products": [ "species_10646438", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10646427": { "compartment": "compartment_7660", "id": "reaction_10646427", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10646028", "species_113685" ], "products": [ "species_159942", "species_10641602", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10642588": { "compartment": "compartment_7660", "id": "reaction_10642588", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614312", "species_10638588" ], "products": [ "species_10642586" ], "modifiers": [ [ "species_10642554", "inhibitor" ] ], "additional_components": [ "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10641564": { "compartment": "compartment_7660", "id": "reaction_10641564", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641547", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646429": { "compartment": "compartment_7660", "id": "reaction_10646429", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642356", "species_113671", "species_113685" ], "products": [ "species_10638866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10639435": { "compartment": "compartment_7660", "id": "reaction_10639435", "reactome": "R-CEL-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639388", "species_113560" ], "products": [ "species_2485002", "species_10639394" ], "modifiers": [ [ "species_10639432", "catalyst" ] ], "additional_components": [ "WBGene00001914", "WBGene00001914", "A3QMD7", "WBGene00020287", "Q95ZX6", "WBGene00007914", "Q9N3F6", "WBGene00021810", "Q8WQC3", "WBGene00015001" ] }, "reaction_10641627": { "compartment": "compartment_7660", "id": "reaction_10641627", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641602", "species_113671", "species_113685" ], "products": [ "species_10641610", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641624", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646425": { "compartment": "compartment_7660", "id": "reaction_10646425", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641673", "species_113685" ], "products": [ "species_10641545", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641538", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00012982" ] }, "reaction_10641572": { "compartment": "compartment_7660", "id": "reaction_10641572", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638866", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004205" ] }, "reaction_10645990": { "compartment": "compartment_7660", "id": "reaction_10645990", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641526", "species_77087" ], "products": [ "species_10645980", "species_77502" ], "modifiers": [ [ "species_10641710", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XV44", "WBGene00009370", "Q8I4F7", "WBGene00044070", "Q23084", "WBGene00022499", "Q09415", "WBGene00011068" ] }, "reaction_10646415": { "compartment": "compartment_7660", "id": "reaction_10646415", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10642749", "species_113685" ], "products": [ "species_10641580", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641585", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00004319" ] }, "reaction_10645875": { "compartment": "compartment_70101", "id": "reaction_10645875", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10645859" ], "products": [ "species_71285", "species_10645865" ], "modifiers": [ [ "species_10645870", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00001207" ] }, "reaction_10642584": { "compartment": "compartment_7660", "id": "reaction_10642584", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641985", "species_10642554" ], "products": [ "species_10642582" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914" ] }, "reaction_10645934": { "compartment": "compartment_7660", "id": "reaction_10645934", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638586", "species_77087" ], "products": [ "species_10641580", "species_77502" ], "modifiers": [ [ "species_10642753", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q09415", "WBGene00011068", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10641543": { "compartment": "compartment_7660", "id": "reaction_10641543", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10641526", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10638588" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646413": { "compartment": "compartment_7660", "id": "reaction_10646413", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641545", "species_113671", "species_113685" ], "products": [ "species_10641547", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10641561", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10646026": { "compartment": "compartment_7660", "id": "reaction_10646026", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10645998", "species_77502" ], "modifiers": [ [ "species_10646011", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00021474" ] }, "reaction_10646431": { "compartment": "compartment_7660", "id": "reaction_10646431", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641580" ], "products": [ "species_10638586", "species_29478" ], "modifiers": [ [ "species_10638595", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q21988", "WBGene00000137", "Q9XXU5", "WBGene00000138" ] }, "reaction_10640361": { "compartment": "compartment_7660", "id": "reaction_10640361", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640182", "species_113518" ], "products": [ "species_10640188", "species_5566518" ], "modifiers": [ [ "species_10640358", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q20296", "WBGene00018319", "Q8I4I9", "WBGene00009663", "Q9U266", "WBGene00001838" ] }, "reaction_10646411": { "compartment": "compartment_7660", "id": "reaction_10646411", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645980", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10641526", "species_29478" ], "modifiers": [ [ "species_10641540", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10646435": { "compartment": "compartment_7660", "id": "reaction_10646435", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642363", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10642265" ], "modifiers": [ [ "species_10641569", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10644106": { "compartment": "compartment_7660", "id": "reaction_10644106", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_77502", "species_10636181" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10644109": { "compartment": "compartment_7660", "id": "reaction_10644109", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10636181" ], "products": [ "species_159942", "species_159939", "species_10602463", "species_29478" ], "modifiers": [ [ "species_10636190", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10641995": { "compartment": "compartment_7660", "id": "reaction_10641995", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10638588" ], "products": [ "species_10638586", "species_77502" ], "modifiers": [ [ "species_10641992", "catalyst" ] ], "additional_components": [ "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q17963", "WBGene00006474", "Q09309", "WBGene00017683", "G5EGI1", "WBGene00011729", "Q18221", "WBGene00004782", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458" ] }, "reaction_10640129": { "compartment": "compartment_7660", "id": "reaction_10640129", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639929", "species_113560" ], "products": [ "species_2485002", "species_10640126" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00000366" ] }, "reaction_10642268": { "compartment": "compartment_7660", "id": "reaction_10642268", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_77087" ], "products": [ "species_10642265", "species_77502" ], "modifiers": [ [ "species_10638603", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10639915": { "compartment": "compartment_7660", "id": "reaction_10639915", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602463", "species_113560" ], "products": [ "species_2485002", "species_10639905" ], "modifiers": [ [ "species_10639912", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q21484", "WBGene00044069" ] }, "reaction_10617848": { "compartment": "compartment_17951", "id": "reaction_10617848", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_141343" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10617805": { "compartment": "compartment_17951", "id": "reaction_10617805", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10617802", "catalyst" ] ], "additional_components": [ "Q20992", "WBGene00019060", "species_113596" ] }, "reaction_10617812": { "compartment": "compartment_17951", "id": "reaction_10617812", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617810": { "compartment": "compartment_17951", "id": "reaction_10617810", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10617814": { "compartment": "compartment_17951", "id": "reaction_10617814", "reactome": "R-CEL-390224", "name": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389996", "species_193514" ], "products": [ "species_390002", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10617795": { "compartment": "compartment_17951", "id": "reaction_10617795", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10617807": { "compartment": "compartment_17951", "id": "reaction_10617807", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10617835": { "compartment": "compartment_17951", "id": "reaction_10617835", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_390271" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10617832", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10617845": { "compartment": "compartment_17951", "id": "reaction_10617845", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_353123" ], "products": [ "species_193514", "species_390287" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10617843": { "compartment": "compartment_17951", "id": "reaction_10617843", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390294", "species_192314" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10617840", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10610040": { "compartment": "compartment_70101", "id": "reaction_10610040", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10610037", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10610751": { "compartment": "compartment_70101", "id": "reaction_10610751", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196420" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610020": { "compartment": "compartment_70101", "id": "reaction_10610020", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10610017", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10661829": { "compartment": "compartment_70101", "id": "reaction_10661829", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10661826", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10642772": { "compartment": "compartment_17957", "id": "reaction_10642772", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10642769", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10610030": { "compartment": "compartment_70101", "id": "reaction_10610030", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10610027", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10610012": { "compartment": "compartment_70101", "id": "reaction_10610012", "reactome": "R-CEL-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10610050": { "compartment": "compartment_70101", "id": "reaction_10610050", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10610047", "catalyst" ] ], "additional_components": [ "G5EFQ1", "WBGene00019460", "species_109496" ] }, "reaction_10666341": { "compartment": "compartment_12045", "id": "reaction_10666341", "reactome": "R-CEL-9755937", "name": "DHCR24 reduces LAN to 24,25-dhLAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634" ], "products": [ "species_29366", "species_1130708" ], "modifiers": [ [ "species_10610748", "catalyst" ], [ "species_10666337", "catalyst" ] ], "additional_components": [ "WBGene00018718", "WBGene00004735" ] }, "reaction_10610068": { "compartment": "compartment_70101", "id": "reaction_10610068", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10610065", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10610060": { "compartment": "compartment_70101", "id": "reaction_10610060", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10610057", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10655790": { "compartment": "compartment_12045", "id": "reaction_10655790", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_29366", "species_6807048" ], "modifiers": [ [ "species_10610748", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10610015": { "compartment": "compartment_70101", "id": "reaction_10610015", "reactome": "R-CEL-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10610009", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_109496" ] }, "reaction_10655788": { "compartment": "compartment_12045", "id": "reaction_10655788", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6807057" ], "products": [ "species_29366", "species_193384" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10610743": { "compartment": "compartment_70101", "id": "reaction_10610743", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_195655" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10610740", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10638184": { "compartment": "compartment_7660", "id": "reaction_10638184", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638084", "species_10638173" ], "products": [ "species_10638181", "species_10638069" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10655749": { "compartment": "compartment_984", "id": "reaction_10655749", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614867" ], "products": [ "species_10655694" ], "modifiers": [], "additional_components": [ "WBGene00001972", "WBGene00001972" ] }, "reaction_10655698": { "compartment": "compartment_984", "id": "reaction_10655698", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_181015" ], "products": [ "species_10655696" ], "modifiers": [], "additional_components": [ "WBGene00001972", "Q09390", "WBGene00001972", "species_181015" ] }, "reaction_10659495": { "compartment": "compartment_984", "id": "reaction_10659495", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10607100" ], "products": [ "species_10659493" ], "modifiers": [], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_2186967", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563" ] }, "reaction_10655702": { "compartment": "compartment_984", "id": "reaction_10655702", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655694", "species_166005" ], "products": [ "species_10655700" ], "modifiers": [], "additional_components": [ "WBGene00001972", "species_166005", "Q09390", "WBGene00001972" ] }, "reaction_10607106": { "compartment": "compartment_984", "id": "reaction_10607106", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607100", "species_166005" ], "products": [ "species_10607102" ], "modifiers": [ [ "species_10607104", "inhibitor" ] ], "additional_components": [ "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "Q18869", "WBGene00020563", "Q17738", "WBGene00020563", "H9G2Z8", "WBGene00020563", "Q20380", "WBGene00020563", "Q93796", "WBGene00003812", "Q23365", "WBGene00022627", "species_166005", "A8WFJ7", "WBGene00020563", "Q17654", "WBGene00020563", "Q10011", "WBGene00020563", "O17768", "WBGene00020563", "WBGene00022627" ] }, "reaction_10661651": { "compartment": "compartment_70101", "id": "reaction_10661651", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661647" ], "products": [ "species_10661649" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661665": { "compartment": "compartment_70101", "id": "reaction_10661665", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625310", "species_10628559" ], "products": [ "species_10628565" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661629": { "compartment": "compartment_70101", "id": "reaction_10661629", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661619" ], "products": [ "species_10661627" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661661": { "compartment": "compartment_70101", "id": "reaction_10661661", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661617" ], "products": [ "species_10661619" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661659": { "compartment": "compartment_70101", "id": "reaction_10661659", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628565" ], "products": [ "species_10628577" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10611863": { "compartment": "compartment_70101", "id": "reaction_10611863", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611857" ], "products": [ "species_10611861", "species_10611859" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000072", "WBGene00000072", "WBGene00000072", "P42573", "WBGene00000417" ] }, "reaction_10611874": { "compartment": "compartment_70101", "id": "reaction_10611874", "reactome": "R-CEL-201622", "name": "Caspase-mediated cleavage of gelsolin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611868" ], "products": [ "species_10611870", "species_10611872" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010593", "WBGene00010593", "WBGene00010593", "P42573", "WBGene00000417" ] }, "reaction_10612305": { "compartment": "compartment_70101", "id": "reaction_10612305", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612299" ], "products": [ "species_10612303", "species_10612301" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10612294": { "compartment": "compartment_70101", "id": "reaction_10612294", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612288" ], "products": [ "species_10612290", "species_10612292" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10636129": { "compartment": "compartment_161320", "id": "reaction_10636129", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_1678868", "species_2162223" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10665108": { "compartment": "compartment_161320", "id": "reaction_10665108", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636011": { "compartment": "compartment_161320", "id": "reaction_10636011", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160864", "species_1605715" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10636127": { "compartment": "compartment_161320", "id": "reaction_10636127", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162224", "species_1605715" ], "products": [ "species_1678868", "species_1678743" ], "modifiers": [ [ "species_10633421", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10636032": { "compartment": "compartment_876", "id": "reaction_10636032", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636029" ], "products": [ "species_2160894", "species_10636029" ], "modifiers": [ [ "species_10636029", "catalyst" ] ], "additional_components": [ "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731", "G5ECE8", "WBGene00011923", "G5EBK1", "WBGene00003943", "species_2162224", "species_74016", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q23643", "WBGene00014109", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10636125": { "compartment": "compartment_161320", "id": "reaction_10636125", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10609537": { "compartment": "compartment_7660", "id": "reaction_10609537", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609448" ], "products": [ "species_10598143", "species_10609440", "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609431": { "compartment": "compartment_7660", "id": "reaction_10609431", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609423" ], "products": [ "species_113582", "species_10609428" ], "modifiers": [ [ "species_10609423", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598270": { "compartment": "compartment_7660", "id": "reaction_10598270", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598260" ], "products": [ "species_10598262" ], "modifiers": [ [ "species_10598267", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00000794" ] }, "reaction_10609442": { "compartment": "compartment_7660", "id": "reaction_10609442", "reactome": "R-CEL-187545", "name": "Association of Cks1 with SCF(Skp2) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609433", "species_10609438" ], "products": [ "species_10609440" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "WBGene00001051", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10598156": { "compartment": "compartment_70101", "id": "reaction_10598156", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598154" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P91155", "WBGene00000382", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10609606": { "compartment": "compartment_7660", "id": "reaction_10609606", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609602" ], "products": [ "species_113582", "species_10609604" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "G5EDT1", "WBGene00003020", "Q09649", "WBGene00001510", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609421": { "compartment": "compartment_13231", "id": "reaction_10609421", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419" ], "products": [ "species_10598355" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10598146": { "compartment": "compartment_7660", "id": "reaction_10598146", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597697" ], "products": [ "species_113582", "species_10598123" ], "modifiers": [ [ "species_10598143", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597902": { "compartment": "compartment_7660", "id": "reaction_10597902", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597874", "species_10597841" ], "products": [ "species_10597877" ], "modifiers": [ [ "species_10597899", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00012650", "WBGene00012650", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10598204": { "compartment": "compartment_7660", "id": "reaction_10598204", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598198" ], "products": [ "species_10598185", "species_10598202" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10608079": { "compartment": "compartment_13231", "id": "reaction_10608079", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607961" ], "products": [ "species_10607975" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609540": { "compartment": "compartment_7660", "id": "reaction_10609540", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609444", "species_10597874" ], "products": [ "species_10609448" ], "modifiers": [ [ "species_10609444", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051", "WBGene00006727", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598158": { "compartment": "compartment_7660", "id": "reaction_10598158", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597820" ], "products": [ "species_10597811", "species_10597804", "species_10597787", "species_10597816" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "WBGene00003157" ] }, "reaction_10598150": { "compartment": "compartment_7660", "id": "reaction_10598150", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598123" ], "products": [ "species_10598148" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10636953": { "compartment": "compartment_7660", "id": "reaction_10636953", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636933", "species_113560" ], "products": [ "species_2485002", "species_10636941" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10597749": { "compartment": "compartment_7660", "id": "reaction_10597749", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10597744" ], "products": [ "species_10597740", "species_10597746" ], "modifiers": [ [ "species_10597744", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10598258": { "compartment": "compartment_7660", "id": "reaction_10598258", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598249", "species_10598254" ], "products": [ "species_10598256" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "WBGene00001016", "Q9U3F2", "WBGene00001016", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10610968": { "compartment": "compartment_70101", "id": "reaction_10610968", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609419", "species_113592" ], "products": [ "species_29370", "species_10610965" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10597906": { "compartment": "compartment_7660", "id": "reaction_10597906", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597877" ], "products": [ "species_10597904" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10636990": { "compartment": "compartment_7660", "id": "reaction_10636990", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636986", "species_113560" ], "products": [ "species_2485002", "species_10636988" ], "modifiers": [ [ "species_10636950", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10598189": { "compartment": "compartment_7660", "id": "reaction_10598189", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113", "species_10598185" ], "products": [ "species_10598187" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10598200": { "compartment": "compartment_7660", "id": "reaction_10598200", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598196", "species_10598187" ], "products": [ "species_113582", "species_10598198" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "C7IVS4", "WBGene00012936", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q21625", "WBGene00001002" ] }, "reaction_10608402": { "compartment": "compartment_7660", "id": "reaction_10608402", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608388", "species_10608383", "species_10608393", "species_10608398" ], "products": [ "species_10608400" ], "modifiers": [], "additional_components": [ "WBGene00009287", "WBGene00011275", "WBGene00022043", "WBGene00013768", "Q9U2W9", "WBGene00013768", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043", "Q22019", "WBGene00011275" ] }, "reaction_10598232": { "compartment": "compartment_7660", "id": "reaction_10598232", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598225" ], "products": [ "species_10598229" ], "modifiers": [ [ "species_10598223", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645" ] }, "reaction_10607963": { "compartment": "compartment_70101", "id": "reaction_10607963", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10607594" ], "products": [ "species_10607961" ], "modifiers": [], "additional_components": [ "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609608": { "compartment": "compartment_7660", "id": "reaction_10609608", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607975", "species_29358" ], "products": [ "species_113582", "species_10597866" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10598278": { "compartment": "compartment_7660", "id": "reaction_10598278", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10609598": { "compartment": "compartment_7660", "id": "reaction_10609598", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609593" ], "products": [ "species_113582", "species_10609595" ], "modifiers": [ [ "species_10609593", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10598116": { "compartment": "compartment_7660", "id": "reaction_10598116", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10597746", "species_29604", "species_29892" ], "products": [ "species_10598113" ], "modifiers": [ [ "species_10597721", "catalyst" ] ], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10597869": { "compartment": "compartment_7660", "id": "reaction_10597869", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597822" ], "products": [ "species_10597845", "species_113582", "species_10597841" ], "modifiers": [ [ "species_10597866", "catalyst" ] ], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00012650", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10609446": { "compartment": "compartment_7660", "id": "reaction_10609446", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10609428" ], "products": [ "species_10609444" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q6A590", "WBGene00020884", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EEJ2", "WBGene00000517", "H2L0L4", "WBGene00020461", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "P34638", "WBGene00000863", "Q17868", "WBGene00001051" ] }, "reaction_10598227": { "compartment": "compartment_7660", "id": "reaction_10598227", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598202", "species_10598223" ], "products": [ "species_10598225" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598236": { "compartment": "compartment_7660", "id": "reaction_10598236", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598229" ], "products": [ "species_10598234" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "Q19366", "WBGene00008722", "P34471", "WBGene00004180", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q21625", "WBGene00001002" ] }, "reaction_10598111": { "compartment": "compartment_70101", "id": "reaction_10598111", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597904" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00012650", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607697": { "compartment": "compartment_876", "id": "reaction_10607697", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607678" ], "products": [ "species_10607692", "species_29372" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607687": { "compartment": "compartment_876", "id": "reaction_10607687", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607685" ], "products": [ "species_10607683", "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10608410": { "compartment": "compartment_70101", "id": "reaction_10608410", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608404" ], "products": [ "species_29370", "species_10608407" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10607674": { "compartment": "compartment_876", "id": "reaction_10607674", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607671", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "species_29420", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607694": { "compartment": "compartment_876", "id": "reaction_10607694", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607692" ], "products": [ "species_10604895", "species_10607669" ], "modifiers": [], "additional_components": [ "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "species_29420", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745" ] }, "reaction_10607216": { "compartment": "compartment_70101", "id": "reaction_10607216", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607202" ], "products": [ "species_10607214", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "species_29420", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681" ] }, "reaction_10607219": { "compartment": "compartment_70101", "id": "reaction_10607219", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10607214" ], "products": [ "species_10605068" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "A0A3B1DQQ4", "WBGene00006864", "G5ECT6", "WBGene00001682", "Q09502", "WBGene00008065", "G5EGU1", "WBGene00001196", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_29438", "Q9XVQ0", "WBGene00018089", "Q20841", "WBGene00018886", "A0A0K3AXD3", "WBGene00011372", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "Q23033", "WBGene00020086", "P54406", "WBGene00001681", "WBGene00001196" ] }, "reaction_10604848": { "compartment": "compartment_70101", "id": "reaction_10604848", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10607198": { "compartment": "compartment_947587", "id": "reaction_10607198", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843", "species_29420" ], "products": [ "species_29438", "species_10604969" ], "modifiers": [ [ "species_10604837", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "WBGene00001196" ] }, "reaction_10665289": { "compartment": "compartment_70101", "id": "reaction_10665289", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10608407", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10604971": { "compartment": "compartment_70101", "id": "reaction_10604971", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604845", "species_29356" ], "products": [ "species_10604832", "species_10604969", "species_29372" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "WBGene00001177", "species_29420", "G5EGU1", "WBGene00001196" ] }, "reaction_10607700": { "compartment": "compartment_876", "id": "reaction_10607700", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607667" ], "products": [ "species_10607685", "species_29372" ], "modifiers": [ [ "species_10607667", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "species_29420", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_111349", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10604931": { "compartment": "compartment_70101", "id": "reaction_10604931", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10607690": { "compartment": "compartment_876", "id": "reaction_10607690", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10607678", "catalyst" ] ], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607221": { "compartment": "compartment_947587", "id": "reaction_10607221", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604969", "species_10605064" ], "products": [ "species_10607200" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10607676": { "compartment": "compartment_876", "id": "reaction_10607676", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607665", "species_10607647" ], "products": [ "species_10607667" ], "modifiers": [], "additional_components": [ "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "species_109496", "Q9N2V6", "WBGene00001678", "Q966F9", "WBGene00000071", "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "Q9BIG5", "WBGene00001666", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q9N2V6", "WBGene00001678", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071" ] }, "reaction_10607681": { "compartment": "compartment_876", "id": "reaction_10607681", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607647", "species_10604895" ], "products": [ "species_10607678" ], "modifiers": [ [ "species_10604895", "catalyst" ] ], "additional_components": [ "species_29438", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_29438", "V6CLB7", "WBGene00020997", "species_109496", "Q7KPV0", "WBGene00001745", "Q966F9", "WBGene00000071", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "species_109496", "Q966F9", "WBGene00000071" ] }, "reaction_10628746": { "compartment": "compartment_1222693", "id": "reaction_10628746", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10628743", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10650440": { "compartment": "compartment_21994", "id": "reaction_10650440", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10650430" ], "products": [ "species_10650432" ], "modifiers": [], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650435": { "compartment": "compartment_21994", "id": "reaction_10650435", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650432", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10658173": { "compartment": "compartment_984", "id": "reaction_10658173", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10658170", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10650438": { "compartment": "compartment_1222282", "id": "reaction_10650438", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10660758": { "compartment": "compartment_1222282", "id": "reaction_10660758", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10650430", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:55376", "Q20616", "WBGene00009897" ] }, "reaction_10621247": { "compartment": "compartment_172574", "id": "reaction_10621247", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10621244", "catalyst" ] ], "additional_components": [ "species_216667", "species_113531", "species_266099", "species_216667", "species_113531", "species_266099", "Q21434", "WBGene00004876", "Q21433", "WBGene00004877", "Q95XG8", "WBGene00004878" ] }, "reaction_10664718": { "compartment": "compartment_70101", "id": "reaction_10664718", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647011", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665968": { "compartment": "compartment_7660", "id": "reaction_10665968", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611187" ], "products": [ "species_10664881" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10665966": { "compartment": "compartment_7660", "id": "reaction_10665966", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662906": { "compartment": "compartment_876", "id": "reaction_10662906", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10662895" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10636260": { "compartment": "compartment_70101", "id": "reaction_10636260", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_29438" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10636257", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10624986": { "compartment": "compartment_876", "id": "reaction_10624986", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605064", "species_10607683" ], "products": [ "species_10616840" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10655747": { "compartment": "compartment_984", "id": "reaction_10655747", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6805204", "species_10655743" ], "products": [ "species_10655745" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_6805204" ] }, "reaction_10624999": { "compartment": "compartment_876", "id": "reaction_10624999", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618849", "species_10605064" ], "products": [ "species_10605451" ], "modifiers": [], "additional_components": [ "species_111349", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616840", "species_10616838" ], "products": [ "species_10616842" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794" ] }, "reaction_10618991": { "compartment": "compartment_984", "id": "reaction_10618991", "reactome": "R-CEL-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616818", "species_419339" ], "products": [ "species_10616820" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "species_419339", "P91439", "WBGene00020319", "O76667", "WBGene00019183" ] }, "reaction_10666012": { "compartment": "compartment_70101", "id": "reaction_10666012", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10666009", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10617905": { "compartment": "compartment_984", "id": "reaction_10617905", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616408", "species_114523" ], "products": [ "species_10616410" ], "modifiers": [], "additional_components": [ "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "Q86ME6", "WBGene00001052", "species_114523" ] }, "reaction_10617893": { "compartment": "compartment_984", "id": "reaction_10617893", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10616744" ], "products": [ "species_10616748" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10662902": { "compartment": "compartment_876", "id": "reaction_10662902", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662899" ], "products": [ "species_10662895" ], "modifiers": [ [ "species_10662899", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10666056": { "compartment": "compartment_70101", "id": "reaction_10666056", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10604928", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10617968": { "compartment": "compartment_984", "id": "reaction_10617968", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616790", "species_416911" ], "products": [ "species_10616792" ], "modifiers": [], "additional_components": [ "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "species_879629", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086" ] }, "reaction_10636281": { "compartment": "compartment_876", "id": "reaction_10636281", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636278" ], "products": [ "species_10630578" ], "modifiers": [ [ "species_10618504", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624788": { "compartment": "compartment_876", "id": "reaction_10624788", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616656", "species_10605486" ], "products": [ "species_10616658" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "species_205687", "CHEBI:15650", "species_266074", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "species_74016", "CHEBI:28875", "species_113552", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794" ] }, "reaction_10651371": { "compartment": "compartment_876", "id": "reaction_10651371", "reactome": "R-CEL-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10651368", "catalyst" ] ], "additional_components": [ "WBGene00011524" ] }, "reaction_10621741": { "compartment": "compartment_984", "id": "reaction_10621741", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10621737" ], "products": [ "species_10621739" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "G5ECX0", "WBGene00002252", "species_444761", "Q19930", "WBGene00017947" ] }, "reaction_10624997": { "compartment": "compartment_70101", "id": "reaction_10624997", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624992" ], "products": [ "species_10624988", "species_29420" ], "modifiers": [ [ "species_10624992", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618959": { "compartment": "compartment_984", "id": "reaction_10618959", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_417888" ], "products": [ "species_10616605" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_205687" ] }, "reaction_10663247": { "compartment": "compartment_876", "id": "reaction_10663247", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663242" ], "products": [ "species_10663229", "species_10605484" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_111349" ] }, "reaction_10618506": { "compartment": "compartment_876", "id": "reaction_10618506", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604943", "species_114519" ], "products": [ "species_10618504" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10624961": { "compartment": "compartment_984", "id": "reaction_10624961", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616660" ], "products": [ "species_10605064", "species_10624953", "species_10624959", "species_10604843" ], "modifiers": [], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q95YD7", "WBGene00016265", "O62403", "WBGene00013782", "O44536", "WBGene00019224", "O18014", "WBGene00011381", "G5EBX8", "WBGene00008890", "A0A3B1DQQ4", "WBGene00006864", "O17239", "WBGene00019616", "Q09502", "WBGene00008065", "O44731", "WBGene00018798", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "Q23265", "WBGene00013871", "Q20841", "WBGene00018886", "Q09638", "WBGene00012084", "Q23497", "WBGene00013974", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "Q20325", "WBGene00018344", "H9G358", "WBGene00018089", "G5EDI0", "WBGene00007395", "A0A0K3AYF5", "C16D6.2b", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "A0A2C9C3A4", "WBGene00018089", "Q18130", "WBGene00016044", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q9XVS5", "WBGene00007614", "Q18701", "WBGene00016747", "A0A0K3AXD3", "WBGene00011372", "Q19399", "WBGene00008736", "Q03566", "WBGene00006576", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "P91096", "WBGene00016037", "Q23033", "WBGene00020086", "CHEBI:6498", "species_374935", "CHEBI:28364", "species_29370", "CHEBI:30772", "species_265287", "CHEBI:53460", "species_8869214", "species_2046056", "species_427486", "CHEBI:53487", "CHEBI:17120", "species_205687", "CHEBI:15650", "species_390899", "Q93518", "WBGene00008879", "species_216667", "CHEBI:50122", "species_113552", "CHEBI:30212", "species_29460", "CHEBI:28716", "species_29468", "CHEBI:42504", "species_264643", "species_2066763", "species_8934421", "species_390435", "species_879535", "species_29444", "CHEBI:15627", "species_209849", "CHEBI:30768", "species_266074", "CHEBI:30805", "CHEBI:16196", "Q10651", "WBGene00000149", "species_74016", "CHEBI:28875", "species_70106", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "species_113585", "CHEBI:27997", "species_113592", "CHEBI:31011", "species_266056", "species_209794", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618957": { "compartment": "compartment_984", "id": "reaction_10618957", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10616766" ], "products": [ "species_10616768" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10618961": { "compartment": "compartment_984", "id": "reaction_10618961", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616447", "species_83908" ], "products": [ "species_10616449" ], "modifiers": [], "additional_components": [ "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "species_83909", "Q19295", "WBGene00017338" ] }, "reaction_10665053": { "compartment": "compartment_70101", "id": "reaction_10665053", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10665050", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10605432": { "compartment": "compartment_70101", "id": "reaction_10605432", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10605429", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10615432": { "compartment": "compartment_984", "id": "reaction_10615432", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615428", "species_210382" ], "products": [ "species_10615430" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "species_113552", "Q09630", "WBGene00003232" ] }, "reaction_10617972": { "compartment": "compartment_984", "id": "reaction_10617972", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616631", "species_416436" ], "products": [ "species_10616633" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "species_266056", "Q9XVS5", "WBGene00007614" ] }, "reaction_10664924": { "compartment": "compartment_984", "id": "reaction_10664924", "reactome": "R-CEL-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615597", "species_9615246" ], "products": [ "species_10664922" ], "modifiers": [], "additional_components": [ "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=587", "LigandDisplayForward?ligandId=592", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590", "LigandDisplayForward?ligandId=587", "Q09638", "WBGene00012084", "LigandDisplayForward?ligandId=592", "O18014", "WBGene00011381", "LigandDisplayForward?ligandId=588", "LigandDisplayForward?ligandId=589", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "LigandDisplayForward?ligandId=6896", "LigandDisplayForward?ligandId=591", "LigandDisplayForward?ligandId=3937", "LigandDisplayForward?ligandId=590" ] }, "reaction_10617895": { "compartment": "compartment_984", "id": "reaction_10617895", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10616718" ], "products": [ "species_10616720" ], "modifiers": [], "additional_components": [ "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506", "species_380873", "E7EM37", "WBGene00001053", "Q6RYS9", "WBGene00020506" ] }, "reaction_10618573": { "compartment": "compartment_876", "id": "reaction_10618573", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604936", "species_10604843" ], "products": [ "species_10618571" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "Q09639", "WBGene00001709", "species_29438" ] }, "reaction_10605434": { "compartment": "compartment_70101", "id": "reaction_10605434", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605415", "species_10605427" ], "products": [ "species_10605429" ], "modifiers": [], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10616856": { "compartment": "compartment_947587", "id": "reaction_10616856", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616842" ], "products": [ "species_29420", "species_10616846" ], "modifiers": [ [ "species_10616842", "catalyst" ], [ "species_10616852", "inhibitor" ] ], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_879629", "species_111349", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "WBGene00000092" ] }, "reaction_10617897": { "compartment": "compartment_984", "id": "reaction_10617897", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616704" ], "products": [ "species_10616706" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10616667": { "compartment": "compartment_70101", "id": "reaction_10616667", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616658" ], "products": [ "species_10616660", "species_29420" ], "modifiers": [ [ "species_10616664", "catalyst" ] ], "additional_components": [ "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_111349", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "O44536", "WBGene00019224", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "CHEBI:28364", "CHEBI:53460", "Q9U7D5", "WBGene00001519", "species_264643", "species_2066763", "Q23265", "WBGene00013871", "species_2046056", "species_8934421", "G5EG10", "WBGene00003233", "O45601", "WBGene00006459", "species_390435", "CHEBI:53487", "Q20636", "WBGene00001680", "species_205687", "P54406", "WBGene00001681", "CHEBI:15650", "species_266074", "P17343", "WBGene00001679", "CHEBI:16196", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "Q9U320", "WBGene00013642", "G5EGU1", "WBGene00001196", "species_74016", "CHEBI:28875", "species_113552", "species_29438", "species_70106", "Q9XVS5", "WBGene00007614", "species_417891", "species_114523", "CHEBI:28661", "CHEBI:53486", "species_266013", "CHEBI:53488", "Q19399", "WBGene00008736", "CHEBI:28716", "CHEBI:27997", "O17899", "WBGene00010329", "O17470", "WBGene00004776", "species_266056", "P91096", "WBGene00016037", "species_209794", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10662889": { "compartment": "compartment_70101", "id": "reaction_10662889", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662884" ], "products": [ "species_10607663", "species_10662882" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "WBGene00005077" ] }, "reaction_10617899": { "compartment": "compartment_984", "id": "reaction_10617899", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10616392" ], "products": [ "species_10616394" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10624984": { "compartment": "compartment_876", "id": "reaction_10624984", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605484", "species_10605064" ], "products": [ "species_10605486" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "species_111349", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618928": { "compartment": "compartment_876", "id": "reaction_10618928", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604843" ], "products": [ "species_10605484" ], "modifiers": [ [ "species_10604843", "catalyst" ], [ "species_10618926", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EGU1", "WBGene00001196", "species_111349", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10624980": { "compartment": "compartment_984", "id": "reaction_10624980", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616846" ], "products": [ "species_10607663", "species_10605064", "species_10616838" ], "modifiers": [], "additional_components": [ "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q9BIG5", "WBGene00001666", "Q09502", "WBGene00008065", "species_374935", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "O02213", "WBGene00004777", "Q19295", "WBGene00017338", "CHEBI:15650", "species_390899", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "species_113552", "P34311", "WBGene00018089", "species_83909", "Q9N2V6", "WBGene00001678", "G5ECB2", "WBGene00022675", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O76667", "WBGene00019183", "Q23033", "WBGene00020086", "G5ECT6", "WBGene00001682", "P91439", "WBGene00020319", "species_264643", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "H9G358", "WBGene00018089", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "species_266074", "P17343", "WBGene00001679", "E7EM37", "WBGene00001053", "species_352003", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_29438", "species_879629", "Q9XVQ0", "WBGene00018089", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "O62189", "WBGene00009278", "species_209794", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O18014", "WBGene00011381", "species_380873", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "species_374935", "P91439", "WBGene00020319", "Q9U7D5", "WBGene00001519", "species_264643", "Q09638", "WBGene00012084", "Q20841", "WBGene00018886", "Q1ZXT2", "WBGene00011878", "H2L0Q3", "WBGene00021528", "O02213", "WBGene00004777", "H9G358", "WBGene00018089", "Q19295", "WBGene00017338", "CHEBI:15650", "species_266074", "species_390899", "H2KZ99", "WBGene00016570", "E7EM37", "WBGene00001053", "species_352003", "Q19779", "WBGene00017779", "Q6RYS9", "WBGene00020506", "Q18775", "WBGene00016872", "A1IMB8", "WBGene00021152", "species_419339", "A0A2C9C3A4", "WBGene00018089", "species_113552", "P34311", "WBGene00018089", "species_83909", "species_879629", "Q9XVQ0", "WBGene00018089", "G5ECB2", "WBGene00022675", "species_114523", "Q09630", "WBGene00003232", "Q7JP61", "WBGene00006411", "species_266013", "A0A0K3AXD3", "WBGene00011372", "Q19084", "WBGene00017157", "G5EGH0", "WBGene00004779", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "species_209794", "Q23033", "WBGene00020086" ] }, "reaction_10621705": { "compartment": "compartment_984", "id": "reaction_10621705", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10616641" ], "products": [ "species_10616645" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10625140": { "compartment": "compartment_876", "id": "reaction_10625140", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621723", "species_10625136" ], "products": [ "species_10625138" ], "modifiers": [], "additional_components": [ "G5ECX0", "WBGene00002252", "Q19930", "WBGene00017947", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q18849", "WBGene00008314", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "Q19930", "WBGene00017947" ] }, "reaction_10617970": { "compartment": "compartment_984", "id": "reaction_10617970", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616603", "species_416372" ], "products": [ "species_10616770" ], "modifiers": [], "additional_components": [ "WBGene00016570", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "H2KZ99", "WBGene00016570" ] }, "reaction_10624978": { "compartment": "compartment_70101", "id": "reaction_10624978", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624969" ], "products": [ "species_10624975", "species_29420" ], "modifiers": [ [ "species_10624969", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_29438", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q19084", "WBGene00017157", "G5ECT6", "WBGene00001682", "O02213", "WBGene00004777", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10618852": { "compartment": "compartment_876", "id": "reaction_10618852", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618112" ], "products": [ "species_10618849" ], "modifiers": [ [ "species_10618112", "catalyst" ] ], "additional_components": [ "species_29438", "Q19572", "WBGene00001674", "species_111349", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674" ] }, "reaction_10617962": { "compartment": "compartment_984", "id": "reaction_10617962", "reactome": "R-CEL-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616424", "species_10616415" ], "products": [ "species_10616426" ], "modifiers": [], "additional_components": [ "Q21013", "WBGene00001466", "A7DT38", "WBGene00020722", "WBGene00008239", "Q21013", "WBGene00001466", "L8EC40", "WBGene00008239", "A7DT38", "WBGene00020722" ] }, "reaction_10618729": { "compartment": "compartment_984", "id": "reaction_10618729", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616552", "species_417891" ], "products": [ "species_10616554" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10618847": { "compartment": "compartment_70101", "id": "reaction_10618847", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10618844", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "O18696", "WBGene00011433", "Q9N2V9", "WBGene00022389", "P91119", "WBGene00016328" ] }, "reaction_10617901": { "compartment": "compartment_984", "id": "reaction_10617901", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616700", "species_114523" ], "products": [ "species_10616702" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "Q18775", "WBGene00016872", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10665554": { "compartment": "compartment_984", "id": "reaction_10665554", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665550", "species_380873" ], "products": [ "species_10665552" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_380873", "Q6RYS9", "WBGene00020506" ] }, "reaction_10617889": { "compartment": "compartment_984", "id": "reaction_10617889", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616508", "species_372533" ], "products": [ "species_10616514" ], "modifiers": [], "additional_components": [ "WBGene00001519", "Q9U7D5", "WBGene00001519", "species_264643" ] }, "reaction_10618733": { "compartment": "compartment_984", "id": "reaction_10618733", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616548", "species_417891" ], "products": [ "species_10616550" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662897": { "compartment": "compartment_876", "id": "reaction_10662897", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662895" ], "products": [ "species_10608724", "species_10613387", "species_10605064", "species_10617723" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "WBGene00010776", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "WBGene00003911" ] }, "reaction_10617974": { "compartment": "compartment_984", "id": "reaction_10617974", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616599", "species_416372" ], "products": [ "species_10616601" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "Q23265", "WBGene00013871", "CHEBI:15650", "species_266074", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614" ] }, "reaction_10617903": { "compartment": "compartment_984", "id": "reaction_10617903", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616544", "species_114523" ], "products": [ "species_10616546" ], "modifiers": [], "additional_components": [ "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "O45601", "WBGene00006459", "O17470", "WBGene00004776", "P91096", "WBGene00016037", "species_114523" ] }, "reaction_10665773": { "compartment": "compartment_984", "id": "reaction_10665773", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_9684615" ], "products": [ "species_10665771" ], "modifiers": [], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=3634", "LigandDisplayForward?ligandId=5861", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10665777": { "compartment": "compartment_984", "id": "reaction_10665777", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616585", "species_416372" ], "products": [ "species_10616587" ], "modifiers": [ [ "species_10665771", "inhibitor" ] ], "additional_components": [ "Q23265", "WBGene00013871", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "Q23265", "WBGene00013871", "species_266013", "O44536", "WBGene00019224", "Q9U320", "WBGene00013642", "Q19399", "WBGene00008736", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3329", "LigandDisplayForward?ligandId=3327", "O44536", "WBGene00019224", "LigandDisplayForward?ligandId=3334", "LigandDisplayForward?ligandId=10002", "Q9U320", "WBGene00013642", "LigandDisplayForward?ligandId=10346", "LigandDisplayForward?ligandId=3634", "Q9XVS5", "WBGene00007614", "LigandDisplayForward?ligandId=3381", "Q23265", "WBGene00013871", "LigandDisplayForward?ligandId=3322", "LigandDisplayForward?ligandId=6193", "Q19399", "WBGene00008736", "LigandDisplayForward?ligandId=3340", "LigandDisplayForward?ligandId=5861" ] }, "reaction_10605534": { "compartment": "compartment_876", "id": "reaction_10605534", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605529" ], "products": [ "species_10605531" ], "modifiers": [ [ "species_10604845", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177", "species_179856", "species_114520", "G5EGU1", "WBGene00001196", "species_114519", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "species_29438", "G5EBH0", "WBGene00001177" ] }, "reaction_10663233": { "compartment": "compartment_876", "id": "reaction_10663233", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663229", "species_10604843" ], "products": [ "species_10663231" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "G5EGU1", "WBGene00001196", "species_29438", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10662887": { "compartment": "compartment_876", "id": "reaction_10662887", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10662879" ], "products": [ "species_29370", "species_10662884" ], "modifiers": [ [ "species_10662879", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5EE56", "WBGene00005077", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665804": { "compartment": "compartment_984", "id": "reaction_10665804", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10665800" ], "products": [ "species_10665802" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10617640": { "compartment": "compartment_984", "id": "reaction_10617640", "reactome": "R-CEL-389463", "name": "Proteinase-activated receptors can bind thrombin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616635", "species_10605556" ], "products": [ "species_10616639" ], "modifiers": [], "additional_components": [ "WBGene00016570", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "H2KZ99", "WBGene00016570", "species_74016" ] }, "reaction_10618989": { "compartment": "compartment_70101", "id": "reaction_10618989", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10662908": { "compartment": "compartment_70101", "id": "reaction_10662908", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10617723" ], "products": [ "species_10662891" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003911", "Q21430", "WBGene00010776", "Q17850", "WBGene00003911" ] }, "reaction_10662910": { "compartment": "compartment_876", "id": "reaction_10662910", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608722", "species_10662893" ], "products": [ "species_10662899" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "O62422", "WBGene00012532" ] }, "reaction_10663227": { "compartment": "compartment_876", "id": "reaction_10663227", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663225" ], "products": [ "species_10663223", "species_10607683" ], "modifiers": [], "additional_components": [ "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_111349", "Q9N2V6", "WBGene00001678" ] }, "reaction_10664441": { "compartment": "compartment_70101", "id": "reaction_10664441", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838", "species_10612150" ], "products": [ "species_10664439" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "WBGene00021022", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10663245": { "compartment": "compartment_876", "id": "reaction_10663245", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663231" ], "products": [ "species_10663242", "species_29372" ], "modifiers": [ [ "species_10663231", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "species_29420", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5EGU1", "WBGene00001196", "G5ECK9", "WBGene00004351", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "G5EGU1", "WBGene00001196", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353" ] }, "reaction_10621703": { "compartment": "compartment_984", "id": "reaction_10621703", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10616457" ], "products": [ "species_10616459" ], "modifiers": [], "additional_components": [ "CHEBI:16755", "species_176655", "species_5357505", "species_193451", "Q1ZXT2", "WBGene00011878", "Q19779", "WBGene00017779", "Q19295", "WBGene00017338", "Q1ZXT2", "WBGene00011878", "CHEBI:16755", "species_176655", "species_5357505", "Q19779", "WBGene00017779", "species_193451", "Q19295", "WBGene00017338" ] }, "reaction_10619074": { "compartment": "compartment_876", "id": "reaction_10619074", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10616834" ], "products": [ "species_10616836" ], "modifiers": [], "additional_components": [ "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10624994": { "compartment": "compartment_876", "id": "reaction_10624994", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605451", "species_10616523" ], "products": [ "species_10624992" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "G5EBX8", "WBGene00008890", "species_374935", "species_209794", "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_209794", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10618118": { "compartment": "compartment_70101", "id": "reaction_10618118", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613395", "species_10618112" ], "products": [ "species_10618116" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "species_29438", "Q19572", "WBGene00001674", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663240": { "compartment": "compartment_876", "id": "reaction_10663240", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663235" ], "products": [ "species_10663225", "species_29372" ], "modifiers": [ [ "species_10663235", "catalyst" ] ], "additional_components": [ "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "species_29420", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10665930": { "compartment": "compartment_984", "id": "reaction_10665930", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665926", "species_114523" ], "products": [ "species_10665928" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_114523" ] }, "reaction_10618047": { "compartment": "compartment_70101", "id": "reaction_10618047", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10618044", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618122": { "compartment": "compartment_876", "id": "reaction_10618122", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618116", "species_10615544" ], "products": [ "species_10618120" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "G5EFE1", "WBGene00006468", "species_29438", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674" ] }, "reaction_10663237": { "compartment": "compartment_876", "id": "reaction_10663237", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663223", "species_10607663" ], "products": [ "species_10663235" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "Q18563", "WBGene00004349", "Q9BIG5", "WBGene00001666", "Q23376", "WBGene00004352", "G5ECK9", "WBGene00004351", "P49809", "WBGene00001179", "species_29438", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "Q8WQC0", "WBGene00004350", "O45523", "WBGene00004353", "O17589", "WBGene00001145", "Q9N2V6", "WBGene00001678" ] }, "reaction_10616503": { "compartment": "compartment_70101", "id": "reaction_10616503", "reactome": "R-CEL-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10616494" ], "products": [ "species_10616500", "species_29420" ], "modifiers": [ [ "species_10616494", "catalyst" ] ], "additional_components": [ "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_29438", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183", "O18014", "WBGene00011381", "Q21013", "WBGene00001466", "G5ECT6", "WBGene00001682", "species_176655", "P91439", "WBGene00020319", "Q7KPV0", "WBGene00001745", "species_29420", "Q09638", "WBGene00012084", "Q1ZXT2", "WBGene00011878", "Q22895", "WBGene00004780", "species_193451", "Q20325", "WBGene00018344", "Q20636", "WBGene00001680", "A7DT38", "WBGene00020722", "P54406", "WBGene00001681", "Q19295", "WBGene00017338", "species_390899", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "Q19779", "WBGene00017779", "Q86ME6", "WBGene00001052", "species_83909", "species_114523", "CHEBI:16755", "species_5357505", "L8EC40", "WBGene00008239", "O45732", "WBGene00011382", "O62189", "WBGene00009278", "O76667", "WBGene00019183" ] }, "reaction_10624990": { "compartment": "compartment_984", "id": "reaction_10624990", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624988" ], "products": [ "species_10618112", "species_791498", "species_10616519", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5EBX8", "WBGene00008890", "G5ECT6", "WBGene00001682", "species_374935", "Q20636", "WBGene00001680", "species_29438", "species_209794", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_374935", "species_209794", "CHEBI:15627", "WBGene00008890", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618731": { "compartment": "compartment_984", "id": "reaction_10618731", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616556", "species_417891" ], "products": [ "species_10616558" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10662904": { "compartment": "compartment_70101", "id": "reaction_10662904", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662891", "species_10605064" ], "products": [ "species_10662893" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q21430", "WBGene00010776", "G5ECT6", "WBGene00001682", "Q17850", "WBGene00003911", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10647117": { "compartment": "compartment_70101", "id": "reaction_10647117", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646873" ], "products": [ "species_29370", "species_10647115" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10647434": { "compartment": "compartment_70101", "id": "reaction_10647434", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647395", "species_10647430" ], "products": [ "species_10647432" ], "modifiers": [], "additional_components": [ "WBGene00002982", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647477": { "compartment": "compartment_70101", "id": "reaction_10647477", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647430", "species_10647369" ], "products": [ "species_10647441" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882" ] }, "reaction_10647419": { "compartment": "compartment_70101", "id": "reaction_10647419", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647417" ], "products": [ "species_10646885", "species_29370" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647288": { "compartment": "compartment_70101", "id": "reaction_10647288", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646856", "species_113592" ], "products": [ "species_29370", "species_10647285" ], "modifiers": [ [ "species_10646856", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646893": { "compartment": "compartment_17938", "id": "reaction_10646893", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606957" ], "products": [ "species_10617106" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10646897": { "compartment": "compartment_70101", "id": "reaction_10646897", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10606957" ], "products": [ "species_10646861" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647615": { "compartment": "compartment_70101", "id": "reaction_10647615", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647445" ], "products": [ "species_10647430", "species_10647377" ], "modifiers": [], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922" ] }, "reaction_10647545": { "compartment": "compartment_12045", "id": "reaction_10647545", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646885" ], "products": [ "species_10647536" ], "modifiers": [ [ "species_10647541", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "WBGene00020706" ] }, "reaction_10646859": { "compartment": "compartment_70101", "id": "reaction_10646859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646624", "species_113592" ], "products": [ "species_29370", "species_10646856" ], "modifiers": [ [ "species_10646624", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646627": { "compartment": "compartment_70101", "id": "reaction_10646627", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646614" ], "products": [ "species_29370", "species_10646624" ], "modifiers": [ [ "species_10646614", "catalyst" ] ], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647428": { "compartment": "compartment_70101", "id": "reaction_10647428", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632839" ], "products": [ "species_10647417" ], "modifiers": [], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10632894": { "compartment": "compartment_70101", "id": "reaction_10632894", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10632841" ], "products": [ "species_29370", "species_10632847" ], "modifiers": [ [ "species_10632891", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q23669", "WBGene00014151", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10647448": { "compartment": "compartment_70101", "id": "reaction_10647448", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647443" ], "products": [ "species_10647445" ], "modifiers": [ [ "species_10647443", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10647409": { "compartment": "compartment_70101", "id": "reaction_10647409", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647377", "species_5681998" ], "products": [ "species_10647379", "species_10647381" ], "modifiers": [ [ "species_10647406", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "WBGene00021922", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10647424": { "compartment": "compartment_70101", "id": "reaction_10647424", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647285" ], "products": [ "species_10632891" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "Q95XH2", "WBGene00022078", "species_76577", "Q23023", "WBGene00006786", "P45894", "WBGene00019801", "Q22342", "WBGene00020334", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045" ] }, "reaction_10646878": { "compartment": "compartment_70101", "id": "reaction_10646878", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646612", "species_10617093" ], "products": [ "species_10646614" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A3P6NNZ8", "WBGene00020324", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "Q23023", "WBGene00006786", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "P34379", "WBGene00017045", "A0A1T5HUK9", "WBGene00013732", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "O02168", "WBGene00020633" ] }, "reaction_10647475": { "compartment": "compartment_70101", "id": "reaction_10647475", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647456" ], "products": [ "species_10647369" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647422": { "compartment": "compartment_70101", "id": "reaction_10647422", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10633217", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10664110": { "compartment": "compartment_70101", "id": "reaction_10664110", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647432" ], "products": [ "species_10647611" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982" ] }, "reaction_10647532": { "compartment": "compartment_70101", "id": "reaction_10647532", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647369", "species_5681998" ], "modifiers": [ [ "species_10647472", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9U1N6", "WBGene00014080", "K8ESC5", "WBGene00013595" ] }, "reaction_10647613": { "compartment": "compartment_70101", "id": "reaction_10647613", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647381", "species_10647441" ], "products": [ "species_10647443" ], "modifiers": [], "additional_components": [ "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922" ] }, "reaction_10646888": { "compartment": "compartment_12045", "id": "reaction_10646888", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10646885", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932" ] }, "reaction_10647276": { "compartment": "compartment_74700", "id": "reaction_10647276", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647115" ], "products": [ "species_10606979", "species_10646871" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10647565": { "compartment": "compartment_5683628", "id": "reaction_10647565", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647379" ], "products": [ "species_10647556" ], "modifiers": [ [ "species_10647563", "catalyst" ], [ "species_10625721", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_1524083", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "A7DT33", "WBGene00021319", "Q9TXI7", "WBGene00006932", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216" ] }, "reaction_10647681": { "compartment": "compartment_70101", "id": "reaction_10647681", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646871" ], "products": [ "species_10646612", "species_29372" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045", "A0A3P6NNZ8", "WBGene00020324", "Q95XH2", "WBGene00022078", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "P34379", "WBGene00017045" ] }, "reaction_10646876": { "compartment": "compartment_17938", "id": "reaction_10646876", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646861", "species_113592" ], "products": [ "species_29370", "species_10646873" ], "modifiers": [ [ "species_10646861", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A3P6NNZ8", "WBGene00020324", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "A0A3P6NNZ8", "WBGene00020324", "Q68TI8", "WBGene00000911", "Q23023", "WBGene00006786", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "P34379", "WBGene00017045", "species_29420", "Q95XH2", "WBGene00022078", "Q22342", "WBGene00020334", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10647313": { "compartment": "compartment_70101", "id": "reaction_10647313", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647309", "species_5693050" ], "products": [ "species_10647311" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641", "species_1806200", "O16466", "WBGene00018294", "Q86MP3", "WBGene00012641" ] }, "reaction_10647426": { "compartment": "compartment_70101", "id": "reaction_10647426", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647404", "species_10647402" ], "products": [ "species_10647406" ], "modifiers": [], "additional_components": [ "species_5334668", "O16466", "WBGene00018294", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q09406", "WBGene00019427", "species_5334668", "Q19124", "WBGene00017178", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "O16466", "WBGene00018294", "Q09406", "WBGene00019427" ] }, "reaction_10655850": { "compartment": "compartment_6791047", "id": "reaction_10655850", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10649186", "species_10655846" ], "products": [ "species_10655848" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713" ] }, "reaction_10655917": { "compartment": "compartment_6791047", "id": "reaction_10655917", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655913", "species_10655868" ], "products": [ "species_10655915" ], "modifiers": [], "additional_components": [ "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q9N4H7", "WBGene00022119", "Q09654", "WBGene00000180", "Q09236", "WBGene00015734", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "species_29438", "Q20168", "WBGene00009542", "G5EFK4", "WBGene00000183", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "Q22498", "WBGene00011775", "G5EGS5", "WBGene00007703", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EGG0", "WBGene00010713" ] }, "reaction_10655871": { "compartment": "compartment_6791047", "id": "reaction_10655871", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10655864" ], "products": [ "species_29370", "species_10655868" ], "modifiers": [ [ "species_10655864", "catalyst" ] ], "additional_components": [ "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183", "species_29420", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "Q9UAQ6", "WBGene00004266", "G5EGS5", "WBGene00007703", "species_29438", "G5EGG0", "WBGene00010713", "G5EFK4", "WBGene00000183" ] }, "reaction_10656339": { "compartment": "compartment_20699", "id": "reaction_10656339", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10656335" ], "products": [ "species_10656337" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10656333": { "compartment": "compartment_20699", "id": "reaction_10656333", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656329", "species_10656314" ], "products": [ "species_10656331" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q09236", "WBGene00015734", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "Q21408", "WBGene00004951", "Q95ZW1", "WBGene00017273", "Q6AW08", "WBGene00022121", "Q20546", "WBGene00009829", "E0AHA7", "WBGene00006803", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q09473", "WBGene00016195", "Q18849", "WBGene00008314", "Q9N4H7", "WBGene00022119", "Q9U3K1", "WBGene00008687", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q95XZ0", "WBGene00021784", "species_29438", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "O44502", "WBGene00019820", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20797", "WBGene00006373", "Q22498", "WBGene00011775", "Q22328", "WBGene00002976", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "G5EFW3", "WBGene00004855" ] }, "reaction_10656176": { "compartment": "compartment_432051", "id": "reaction_10656176", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656172", "species_10656090" ], "products": [ "species_10656174" ], "modifiers": [], "additional_components": [ "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "O17528", "WBGene00004766", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "P48583", "WBGene00001331", "Q21408", "WBGene00004951", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q22328", "WBGene00002976", "G5EGG0", "WBGene00010713", "G5EFW3", "WBGene00004855", "Q09473", "WBGene00016195", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "O45087", "WBGene00015927", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "species_29420", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "Q18194", "WBGene00016124", "P52275", "WBGene00006537", "Q19020", "WBGene00000962", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "Q9GYR2", "WBGene00016793", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "P41937", "WBGene00006538", "P34685", "WBGene00000292", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q9NA98", "WBGene00013168", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "G5EDD4", "WBGene00006530", "Q09236", "WBGene00015734", "G5EEU1", "WBGene00043064", "Q22799", "WBGene00001005", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q18817", "WBGene00000248", "G5EGG0", "WBGene00010713", "Q19020", "WBGene00000962", "H2L2E8", "WBGene00006528", "G5ED34", "WBGene00001007", "P48583", "WBGene00001331", "Q20168", "WBGene00009542", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q65XS9", "WBGene00043067", "Q22328", "WBGene00002976", "G5EF01", "WBGene00006539", "G5EFW3", "WBGene00004855", "Q9NA98", "WBGene00013168", "O18154", "WBGene00006533", "O45087", "WBGene00015927", "Q9UAQ6", "WBGene00004266", "Q21408", "WBGene00004951", "species_29420", "Q18194", "WBGene00016124", "E0AHA7", "WBGene00006803", "Q20546", "WBGene00009829", "P52275", "WBGene00006537", "Q09473", "WBGene00016195", "Q9N4H7", "WBGene00022119", "Q18849", "WBGene00008314", "Q7YTJ8", "WBGene00012425", "P34686", "WBGene00000293", "O44738", "WBGene00019003", "O17528", "WBGene00004766", "Q9GYR2", "WBGene00016793", "species_29438", "Q9TXZ9", "WBGene00015164", "P12456", "WBGene00003171", "O62246", "WBGene00009732", "P41937", "WBGene00006538", "Q22498", "WBGene00011775", "P34685", "WBGene00000292", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "O17921", "WBGene00006536", "A0AAC1", "WBGene00012424" ] }, "reaction_10621209": { "compartment": "compartment_17906", "id": "reaction_10621209", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_200993" ], "modifiers": [ [ "species_10621206", "catalyst" ] ], "additional_components": [ "Q20121", "WBGene00018152", "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10650696": { "compartment": "compartment_7660", "id": "reaction_10650696", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650680" ], "products": [ "species_10650618" ], "modifiers": [ [ "species_10650605", "catalyst" ], [ "species_10650694", "catalyst" ], [ "species_10650610", "catalyst" ], [ "species_10650678", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "WBGene00012393", "Q95Y89", "WBGene00003063", "Q21086", "WBGene00003821", "Q09958", "WBGene00015941", "WBGene00010709", "Q95Y89", "WBGene00003063", "Q9U2A9", "WBGene00012978", "P91343", "WBGene00018893" ] }, "reaction_10650964": { "compartment": "compartment_7660", "id": "reaction_10650964", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650929" ], "products": [ "species_10650937" ], "modifiers": [ [ "species_10650961", "catalyst" ], [ "species_10650949", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "Q93830", "WBGene00010325", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "Q23223", "WBGene00012342", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "O16207", "WBGene00017916", "Q9N4P9", "WBGene00000202", "Q9XXD2", "WBGene00012966", "WBGene00000798", "WBGene00012342", "WBGene00000796" ] }, "reaction_10650652": { "compartment": "compartment_7660", "id": "reaction_10650652", "reactome": "R-CEL-6791218", "name": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650618" ], "products": [ "species_10601533" ], "modifiers": [ [ "species_10650645", "catalyst" ], [ "species_10650650", "catalyst" ], [ "species_10650623", "catalyst" ], [ "species_10650635", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10650640", "catalyst" ], [ "species_10650630", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q9XWK5", "WBGene00012977", "Q23238", "WBGene00006737", "Q09353", "WBGene00006736", "Q22006", "WBGene00004185", "Q9U1T1", "WBGene00012393", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00001332", "WBGene00012465", "WBGene00021785", "WBGene00017916", "WBGene00012342", "WBGene00000796", "WBGene00001001" ] }, "reaction_10651116": { "compartment": "compartment_7660", "id": "reaction_10651116", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651102" ], "products": [ "species_10651106" ], "modifiers": [ [ "species_10651111", "catalyst" ], [ "species_10650818", "catalyst" ], [ "species_10650794", "catalyst" ], [ "species_10650628", "catalyst" ], [ "species_10651114", "catalyst" ], [ "species_10650772", "catalyst" ] ], "additional_components": [ "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22053", "WBGene00001423", "Q19873", "WBGene00009211", "Q19545", "WBGene00007050", "Q19433", "WBGene00017435", "Q22046", "WBGene00011311", "O18215", "WBGene00013143", "Q2WF63", "WBGene00019219", "Q93638", "WBGene00009266", "Q9XW58", "WBGene00013544", "P34305", "WBGene00015525", "P48150", "WBGene00004483", "O01513", "WBGene00016740", "Q8MNX1", "WBGene00020705", "Q9NEN6", "WBGene00004475", "P42000", "WBGene00015104", "Q23400", "WBGene00022852", "Q18038", "WBGene00002850", "P91280", "WBGene00017855", "Q20228", "WBGene00004478", "Q9N306", "WBGene00022021", "A7DT40", "WBGene00045433", "P41843", "WBGene00020601", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q23312", "WBGene00004476", "P91341", "WBGene00018891", "P51403", "WBGene00004471", "O62518", "WBGene00014083", "Q23494", "WBGene00022742", "Q9XUU8", "WBGene00010582", "Q21276", "WBGene00010627", "Q21736", "WBGene00011032", "Q9N477", "WBGene00021276", "Q23314", "WBGene00013892", "Q9U2I4", "WBGene00012756", "Q09462", "WBGene00007623", "Q9XX15", "WBGene00012652", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "A9D0C6", "WBGene00020171", "O62477", "WBGene00012887", "O16311", "WBGene00015461", "WBGene00006964", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q95XY4", "WBGene00021789", "WBGene00015104", "WBGene00012342", "WBGene00004705", "A7DT40", "WBGene00045433", "Q9XUU8", "WBGene00010582", "Q9N477", "WBGene00021276", "Q23495", "WBGene00022739" ] }, "reaction_10663299": { "compartment": "compartment_70101", "id": "reaction_10663299", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663271" ], "products": [ "species_10663297" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663273": { "compartment": "compartment_70101", "id": "reaction_10663273", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263", "species_10663269" ], "products": [ "species_10663271" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10630255": { "compartment": "compartment_7660", "id": "reaction_10630255", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609440", "species_10628778" ], "products": [ "species_10630253" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00003020", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10665597": { "compartment": "compartment_70101", "id": "reaction_10665597", "reactome": "R-CEL-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665595" ], "products": [ "species_10598308" ], "modifiers": [], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10630260": { "compartment": "compartment_7660", "id": "reaction_10630260", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630253", "species_10597874" ], "products": [ "species_10630257", "species_10609440" ], "modifiers": [ [ "species_10630253", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "WBGene00006727", "G5EDT1", "WBGene00003020", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051", "Q6A590", "WBGene00020884", "G5EDT1", "WBGene00003020", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q17868", "WBGene00001051" ] }, "reaction_10630229": { "compartment": "compartment_7660", "id": "reaction_10630229", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628790" ], "products": [ "species_113550", "species_10628782" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10630231": { "compartment": "compartment_7660", "id": "reaction_10630231", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10628778" ], "products": [ "species_113550", "species_10628748" ], "modifiers": [ [ "species_10630226", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352" ] }, "reaction_10628604": { "compartment": "compartment_12045", "id": "reaction_10628604", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628597" ], "products": [ "species_74016", "species_10628599" ], "modifiers": [ [ "species_10628601", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "species_74016", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10635753": { "compartment": "compartment_12045", "id": "reaction_10635753", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635749", "species_10628599" ], "products": [ "species_10635751" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10635700": { "compartment": "compartment_876", "id": "reaction_10635700", "reactome": "R-CEL-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10635697", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q45FX5", "WBGene00006887", "G5EDP9", "WBGene00000001" ] }, "reaction_10635756": { "compartment": "compartment_70101", "id": "reaction_10635756", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10635751", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10611606": { "compartment": "compartment_876", "id": "reaction_10611606", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611656": { "compartment": "compartment_876", "id": "reaction_10611656", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10611603", "catalyst" ] ], "additional_components": [ "Q9XWL3", "WBGene00012811", "Q20236", "WBGene00009582", "Q9UAZ6", "WBGene00021159", "H2KZC0", "WBGene00016705" ] }, "reaction_10611652": { "compartment": "compartment_70101", "id": "reaction_10611652", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10656006": { "compartment": "compartment_5460", "id": "reaction_10656006", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10656003", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10656014": { "compartment": "compartment_70101", "id": "reaction_10656014", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10656011", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10611619": { "compartment": "compartment_876", "id": "reaction_10611619", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10611616", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10611640": { "compartment": "compartment_70616", "id": "reaction_10611640", "reactome": "R-CEL-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10611637", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10611658": { "compartment": "compartment_70101", "id": "reaction_10611658", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611608": { "compartment": "compartment_70101", "id": "reaction_10611608", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10611650": { "compartment": "compartment_70101", "id": "reaction_10611650", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611660": { "compartment": "compartment_70101", "id": "reaction_10611660", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10655553": { "compartment": "compartment_70101", "id": "reaction_10655553", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_70106", "species_29370", "species_200640", "species_29372" ], "modifiers": [ [ "species_10655550", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10655555": { "compartment": "compartment_5460", "id": "reaction_10655555", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611581": { "compartment": "compartment_70101", "id": "reaction_10611581", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10649581": { "compartment": "compartment_5460", "id": "reaction_10649581", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10649578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10611632": { "compartment": "compartment_70101", "id": "reaction_10611632", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10611629", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10666081": { "compartment": "compartment_70101", "id": "reaction_10666081", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10666078", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10610864": { "compartment": "compartment_70101", "id": "reaction_10610864", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10611642": { "compartment": "compartment_70101", "id": "reaction_10611642", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10610862": { "compartment": "compartment_70101", "id": "reaction_10610862", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10610859", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10610854": { "compartment": "compartment_70101", "id": "reaction_10610854", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10610851", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611647": { "compartment": "compartment_5460", "id": "reaction_10611647", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10611644", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10611622": { "compartment": "compartment_70101", "id": "reaction_10611622", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10611578", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10602950": { "compartment": "compartment_7660", "id": "reaction_10602950", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602938" ], "products": [ "species_10602946" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602940": { "compartment": "compartment_7660", "id": "reaction_10602940", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602934" ], "products": [ "species_10602938" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9NEX2", "WBGene00013736", "Q9N390", "WBGene00021904", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "species_9757634", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10602948": { "compartment": "compartment_7660", "id": "reaction_10602948", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602946" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10661007": { "compartment": "compartment_7660", "id": "reaction_10661007", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661003", "species_10658637" ], "products": [ "species_10661005" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "H2KYY1", "WBGene00016029", "G5EFQ5", "WBGene00004393" ] }, "reaction_10650030": { "compartment": "compartment_70101", "id": "reaction_10650030", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646645", "species_10650024" ], "products": [ "species_10650028" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10650026": { "compartment": "compartment_70101", "id": "reaction_10650026", "reactome": "R-CEL-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10650022" ], "products": [ "species_10650024" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00016500", "Q22915", "WBGene00016500", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10656931": { "compartment": "compartment_70101", "id": "reaction_10656931", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656927", "species_10617956" ], "products": [ "species_10656929" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q20636", "WBGene00001680", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656937": { "compartment": "compartment_70101", "id": "reaction_10656937", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656935" ], "products": [ "species_10656929", "species_29372" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657582": { "compartment": "compartment_70101", "id": "reaction_10657582", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657580" ], "products": [ "species_10657558", "species_10656946" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142" ] }, "reaction_10657586": { "compartment": "compartment_70101", "id": "reaction_10657586", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657576" ], "products": [ "species_10657584", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10617960": { "compartment": "compartment_70101", "id": "reaction_10617960", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617912", "species_10617956" ], "products": [ "species_10617958" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q18425", "WBGene00007918", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656989": { "compartment": "compartment_70101", "id": "reaction_10656989", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656983", "species_10605048" ], "products": [ "species_10656987" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681" ] }, "reaction_10657556": { "compartment": "compartment_70101", "id": "reaction_10657556", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657554" ], "products": [ "species_10656983", "species_10617956" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656981": { "compartment": "compartment_70101", "id": "reaction_10656981", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10656979" ], "products": [ "species_29370", "species_10656946" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10656952": { "compartment": "compartment_70101", "id": "reaction_10656952", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_113592" ], "products": [ "species_29370", "species_10656935" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_113592", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10656950": { "compartment": "compartment_70101", "id": "reaction_10656950", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656929", "species_10656946" ], "products": [ "species_10656948" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "WBGene00003142", "P47208", "WBGene00000379", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391" ] }, "reaction_10657590": { "compartment": "compartment_70101", "id": "reaction_10657590", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656987", "species_10604837" ], "products": [ "species_10657588", "species_10656946" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "P54406", "WBGene00001681", "WBGene00001196", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10657578": { "compartment": "compartment_70101", "id": "reaction_10657578", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657558", "species_10657574" ], "products": [ "species_10657576" ], "modifiers": [], "additional_components": [ "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P47208", "WBGene00000379", "Q9N358", "WBGene00021934", "P41988", "WBGene00000377", "P47209", "WBGene00000380", "Q9N4J8", "WBGene00018782", "P47207", "WBGene00000378", "species_29370", "P49809", "WBGene00001179", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "O17589", "WBGene00001145", "Q9TZS5", "WBGene00020391" ] }, "reaction_10621270": { "compartment": "compartment_1462052", "id": "reaction_10621270", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621267", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10621299": { "compartment": "compartment_876", "id": "reaction_10621299", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10621296", "catalyst" ] ], "additional_components": [ "WBGene00017954" ] }, "reaction_10621278": { "compartment": "compartment_20699", "id": "reaction_10621278", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10621275", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10621262": { "compartment": "compartment_876", "id": "reaction_10621262", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10621259", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621430": { "compartment": "compartment_876", "id": "reaction_10621430", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621427", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10621438": { "compartment": "compartment_12045", "id": "reaction_10621438", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621435", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10621254": { "compartment": "compartment_876", "id": "reaction_10621254", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10621251", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10662865": { "compartment": "compartment_70101", "id": "reaction_10662865", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10662862", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10621286": { "compartment": "compartment_20699", "id": "reaction_10621286", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10621283", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10625287": { "compartment": "compartment_876", "id": "reaction_10625287", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10621419": { "compartment": "compartment_876", "id": "reaction_10621419", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10621507": { "compartment": "compartment_876", "id": "reaction_10621507", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10621504", "catalyst" ] ], "additional_components": [ "O44196", "WBGene00022682", "O02340", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10621483": { "compartment": "compartment_876", "id": "reaction_10621483", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621480", "catalyst" ] ], "additional_components": [ "P91348", "WBGene00018897", "Q9XWH3", "WBGene00013207", "O62192", "WBGene00009286", "Q22395", "WBGene00006486", "Q09957", "WBGene00015940", "Q6BEU0", "WBGene00014669", "U4PS08", "WBGene00021936", "Q19913", "WBGene00017936" ] }, "reaction_10621397": { "compartment": "compartment_876", "id": "reaction_10621397", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10621394", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10606319": { "compartment": "compartment_13231", "id": "reaction_10606319", "reactome": "R-CEL-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604046" ], "products": [ "species_10606317" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10605966": { "compartment": "compartment_70101", "id": "reaction_10605966", "reactome": "R-CEL-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10605960" ], "products": [ "species_10602837", "species_10605964", "species_10602815" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "WBGene00000122", "O61955", "WBGene00002061", "WBGene00003835", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600941": { "compartment": "compartment_7660", "id": "reaction_10600941", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600934" ], "products": [ "species_10600717", "species_10600755", "species_10600936", "species_10600767" ], "modifiers": [ [ "species_10600938", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q19864", "WBGene00000773", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q93716", "WBGene00009668", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "C1P629", "WBGene00008362", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93716", "WBGene00009668" ] }, "reaction_10602612": { "compartment": "compartment_7660", "id": "reaction_10602612", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602608" ], "products": [ "species_10602610", "species_10602600" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q9N5K2", "WBGene00019246", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916" ] }, "reaction_10602861": { "compartment": "compartment_70101", "id": "reaction_10602861", "reactome": "R-CEL-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602857" ], "products": [ "species_10602859", "species_10602825", "species_10602774" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "Q09601", "WBGene00003805", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q9XVS7", "WBGene00003834", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q86G90", "WBGene00003795", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "O01576", "WBGene00003797", "Q17561", "WBGene00000120", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "O62183", "WBGene00000121", "Q7K6X4", "WBGene00003802", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9BKT9", "WBGene00003799", "Q21155", "WBGene00004388", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "G5EEH9", "WBGene00003796", "Q9BL61", "WBGene00022029", "Q17561", "WBGene00000120", "Q8WQF3", "WBGene00004882", "O62185", "WBGene00004706", "Q21832", "WBGene00004387", "O62183", "WBGene00000121", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600807": { "compartment": "compartment_7660", "id": "reaction_10600807", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600800" ], "products": [ "species_10600804", "species_10600794" ], "modifiers": [ [ "species_10600800", "catalyst" ] ], "additional_components": [ "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", 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"WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10605962": { "compartment": "compartment_13231", "id": "reaction_10605962", "reactome": "R-CEL-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604763" ], "products": [ "species_10605960" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600946": { "compartment": "compartment_7660", "id": "reaction_10600946", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600936" ], "products": [ "species_10600734", "species_10600943", "species_10600698", "species_10600739" ], "modifiers": [ [ "species_10600734", "catalyst" ] ], "additional_components": [ "O17403", "WBGene00017313", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "Q93233", "WBGene00003904", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "P34498", "WBGene00003389", "U4PCM1", "WBGene00011051", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "G5EBX5", "WBGene00009658", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q10667", "WBGene00004384", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10600830": { "compartment": "compartment_7660", "id": "reaction_10600830", "reactome": "R-CEL-72143", "name": "Lariat Formation and 5'-Splice Site Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600814", "species_10600804", "species_10600824", "species_10600812", "species_10600819" ], "products": [ "species_10600828" ], "modifiers": [], "additional_components": [ "WBGene00004705", "Q10021", "WBGene00004702", "O17403", "WBGene00017313", "Q9GRZ2", "WBGene00013343", "Q18999", "WBGene00004207", "Q95QN2", "WBGene00017162", "Q95Y51", "WBGene00004891", "O62185", "WBGene00004706", "P34369", "WBGene00004187", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "Q95QR5", "WBGene00016624", "O62213", "WBGene00000472", "Q93233", "WBGene00003904", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "Q965S0", "WBGene00022400", "G5EBY6", "WBGene00004016", "G5ED97", "WBGene00006442", "Q18445", "WBGene00000888", "Q9N3C9", "WBGene00021845", "P91277", "WBGene00017816", "Q9XVH6", "WBGene00012187", "Q9U2U0", "WBGene00006698", "Q9U3I0", "WBGene00009078", "Q9U2G0", "WBGene00012896", "G5EEQ8", "WBGene00011605", "Q19335", "WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", 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"P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q09385", "WBGene00019402", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q9U1Q3", "WBGene00000891", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776" ] }, "reaction_10606328": { "compartment": "compartment_7660", "id": "reaction_10606328", "reactome": "R-CEL-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602797", "species_10600943" ], "products": [ "species_10606325", "species_113550", "species_10602803" ], "modifiers": [ [ "species_10600943", "catalyst" ] ], "additional_components": [ "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384", "species_29370", "Q18212", "WBGene00001840", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "Q9XVS7", "WBGene00003834", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q9XVS8", "WBGene00003835", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "Q9U757", "WBGene00003836", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "Q10667", "WBGene00004384", "Q10021", "WBGene00004702", "Q9N5E3", "WBGene00020172", "Q23120", "WBGene00004699", "P90978", "WBGene00006697", "Q9U3S3", "WBGene00007195", "O62185", "WBGene00004706", "Q8WQF3", "WBGene00004882", "O44729", "WBGene00018625", "O44444", "WBGene00015329", "Q93594", "WBGene00009141", "P91867", "WBGene00009341", "P49029", "WBGene00003123", "G5EDE4", "WBGene00012343", "Q18409", "WBGene00004703", "Q9U2U0", "WBGene00006698", "Q18212", "WBGene00001840", "Q21559", "WBGene00000122", "O01159", "WBGene00004704", "Q9BL61", "WBGene00022029", "C2BR94", "WBGene00021311", "Q17561", "WBGene00000120", "Q18033", "WBGene00015813", "Q21832", "WBGene00004387", "P34498", "WBGene00003389", "O62183", "WBGene00000121", "Q21278", "WBGene00010629", "Q9NEW6", "WBGene00004700", "O01763", "WBGene00018156", "Q9N3G0", "WBGene00021813", "Q21155", "WBGene00004388", "species_113592", "Q10667", "WBGene00004384" ] }, "reaction_10604765": { "compartment": "compartment_7660", "id": "reaction_10604765", "reactome": "R-CEL-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600236", "species_10604757", "species_10602784" ], "products": [ "species_10604763", "species_10599886" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00003835", "Q9XVS8", "WBGene00003835", "Q21559", "WBGene00000122", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10600802": { "compartment": "compartment_7660", "id": "reaction_10600802", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600774", "species_10600769", "species_10600662", "species_10600794", "species_10600779", "species_10600789", "species_10600784" ], "products": [ "species_10600127", "species_10600591", "species_10600461", "species_10600586", "species_10600494", "species_10600800", "species_10600643", "species_10600533", "species_10600581" ], "modifiers": [], "additional_components": [ "WBGene00022029", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797", "Q10021", "WBGene00004702", "Q9GRZ2", 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"Q9U2S6", "WBGene00000889", "Q8ITY4", "WBGene00016808", "Q22307", "WBGene00004355", "Q21322", "WBGene00004385", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "Q9XVS2", "WBGene00045383", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "Q9XUY1", "WBGene00010159", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "P91306", "WBGene00000473", "Q21739", "WBGene00011035", "Q9NLD1", "WBGene00002000", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "P91398", "WBGene00000474", "Q966L5", "WBGene00017085", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "P90815", "WBGene00017238", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9GR61", "WBGene00021347", "Q9XTZ2", "WBGene00004705", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O44787", "WBGene00017280", "Q9U1W8", "WBGene00003077", "P52018", "WBGene00000887", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q21486", "WBGene00010844", "O18694", "WBGene00003079", "Q20875", "WBGene00018967", "Q17336", "WBGene00002957", "Q93339", "WBGene00007972", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19952", "WBGene00003078", "Q95YF1", "WBGene00015581", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", 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"WBGene00008683", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q9U1Q7", "WBGene00001258", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q9U2S6", "WBGene00000889", "P52874", "WBGene00010304", "Q8ITY4", "WBGene00016808", "Q21924", "WBGene00011237", "Q22307", "WBGene00004355", "Q7YTG9", "WBGene00044329", "Q21322", "WBGene00004385", "O16929", "WBGene00017797", "Q9XXI7", "WBGene00000892", "O02092", "WBGene00018391", "Q9XTU6", "WBGene00004919", "Q9XVS2", "WBGene00045383", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "O44729", "WBGene00018625", "Q22836", "WBGene00004806", "Q9NAH3", "WBGene00006563", "O02097", "WBGene00015974", "Q21559", "WBGene00000122", "G5EEL2", "WBGene00006481", "Q17684", "WBGene00007355", "P34498", "WBGene00003389", "Q20966", "WBGene00010233", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q9BIB7", "WBGene00020936", "Q09345", "WBGene00020092", "P91306", "WBGene00000473", "Q9NLD1", "WBGene00002000", "Q95PY8", "WBGene00013460", "Q93382", "WBGene00008119", "Q95Y44", "WBGene00001048", "Q966L5", "WBGene00017085", "P91398", "WBGene00000474", "O45766", "WBGene00011687", "B9WRU1", "WBGene00012769", "Q23120", "WBGene00004699", "Q95Y67", "WBGene00003978", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "G5ECL3", "WBGene00004188", "Q22469", "WBGene00011758", "P91401", "WBGene00019711", "P92022", "WBGene00001808", "Q9XTZ2", "WBGene00004705", "Q9GR61", "WBGene00021347", "Q18409", "WBGene00004703", "G5EFC4", "WBGene00008386", "O01159", "WBGene00004704", "Q20716", "WBGene00009966", "A9D4S6", "WBGene00019762", "Q9BLB6", "WBGene00003390", "P52017", "WBGene00000886", "P91175", "WBGene00016837", "Q9U2P3", "WBGene00012528", "Q20875", "WBGene00018967", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "Q17336", "WBGene00002957", "Q09995", "WBGene00011791", "Q17558", "WBGene00015296", "Q09556", "WBGene00009364", "Q21155", "WBGene00004388", "P34541", "WBGene00019881", "Q9N4G9", "WBGene00004920", "Q9N3S4", "WBGene00004389", "P90978", "WBGene00006697", "Q19864", "WBGene00000773", "Q95YF1", "WBGene00015581", "C1P629", "WBGene00008362", "O16997", "WBGene00021004", "P34313", "WBGene00007400", "O16786", "WBGene00020647", "Q22412", "WBGene00011722", "Q23463", "WBGene00001166", "Q10051", "WBGene00020423", "Q18265", "WBGene00016173", "Q21323", "WBGene00004386", "Q22417", "WBGene00020441", "Q9BL61", "WBGene00022029", "Q93716", "WBGene00009668", "Q21568", "WBGene00010896", "Q4W5P0", "WBGene00022235", "Q9N4C2", "WBGene00022301", "Q19826", "WBGene00017830", "Q9BIC2", "WBGene00020346", "O45244", "WBGene00003392", "G5EDV3", "WBGene00000475", "O45577", "WBGene00000774", "G5EBT5", "WBGene00003391", "A0A0S4XR43", "Y37A1B.1a", "G5EEW6", "WBGene00000890", "Q8MXR2", "WBGene00022253", "Q19866", "WBGene00006307", "Q18535", "WBGene00008034", "Q10667", "WBGene00004384", "Q965K2", "WBGene00018776", "WBGene00008380", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "Q95XD4", "WBGene00003082", "O18694", "WBGene00003079", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "WBGene00017605" ] }, "reaction_10606323": { "compartment": "compartment_70101", "id": "reaction_10606323", "reactome": "R-CEL-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601226", "species_10606317" ], "products": [ "species_10602837", "species_10602815", "species_10606321" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00002061", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "WBGene00000122", "WBGene00003835", "O61955", "WBGene00002061", "Q09599", "WBGene00000411", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10602614": { "compartment": "compartment_7660", "id": "reaction_10602614", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602610" ], "products": [ "species_10602610" ], "modifiers": [], "additional_components": [ "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474", "Q9GRZ2", "WBGene00013343", "Q10021", "WBGene00004702", "Q23120", "WBGene00004699", "Q95QN2", "WBGene00017162", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9XTU6", "WBGene00004919", "Q8MYM8", "WBGene00012694", "P34369", "WBGene00004187", "Q9N5K2", "WBGene00019246", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O62213", "WBGene00000472", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "L8E6I4", "WBGene00235102", "O16997", "WBGene00021004", "P92022", "WBGene00001808", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q23463", "WBGene00001166", "Q18409", "WBGene00004703", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O02097", "WBGene00015974", "Q9U2G0", "WBGene00012896", "Q9U3I0", "WBGene00009078", "G5EEQ8", "WBGene00011605", "Q21568", "WBGene00010896", "Q17684", "WBGene00007355", "Q18786", "WBGene00004917", "Q10013", "WBGene00004916", "Q19826", "WBGene00017830", "G5EDV3", "WBGene00000475", "Q9NEW6", "WBGene00004700", "O44985", "WBGene00019323", "Q93338", "WBGene00007971", "O01763", "WBGene00018156", "Q17558", "WBGene00015296", "Q8ITY4", "WBGene00016808", "P91306", "WBGene00000473", "Q93382", "WBGene00008119", "Q9N4G9", "WBGene00004920", "Q10667", "WBGene00004384", "P91398", "WBGene00000474" ] }, "reaction_10600948": { "compartment": "compartment_7660", "id": "reaction_10600948", "reactome": "R-CEL-72231", "name": "Formation of the Cleavage and Polyadenylation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10600755", "species_10600734", "species_10600767", "species_10600698", "species_10600739" ], "products": [ "species_10600769" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "Q19866", "WBGene00006307", "O16929", "WBGene00017797" ] }, "reaction_10600664": { "compartment": "compartment_7660", "id": "reaction_10600664", "reactome": "R-CEL-72127", "name": "Formation of the Spliceosomal B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604042", "species_10600236", "species_10602784" ], "products": [ "species_10599879", "species_10599884", "species_10604046" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "WBGene00000122", "WBGene00003835", "WBGene00009141", "WBGene00018156", "Q9XVS8", "WBGene00003835", "Q09599", "WBGene00000411", "Q21559", "WBGene00000122", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10645511": { "compartment": "compartment_18730", "id": "reaction_10645511", "reactome": "R-CEL-5625421", "name": "The anterograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645507" ], "products": [ "species_10645492", "species_10645446", "species_10645410", "species_10645462", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10644779": { "compartment": "compartment_20699", "id": "reaction_10644779", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644777" ], "products": [ "species_10644775", "species_10644770" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10645519": { "compartment": "compartment_18730", "id": "reaction_10645519", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645496" ], "products": [ "species_10645515" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645509": { "compartment": "compartment_18730", "id": "reaction_10645509", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645390" ], "products": [ "species_10645507" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645392": { "compartment": "compartment_18730", "id": "reaction_10645392", "reactome": "R-CEL-5624949", "name": "Assembly of the anterograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645336", "species_10645291", "species_10645388", "species_10645216" ], "products": [ "species_10645390" ], "modifiers": [], "additional_components": [ "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P46873", "WBGene00003884", "P12456", "WBGene00003171", "Q19633", "WBGene00002222", "species_29420", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "Q18859", "WBGene00016935", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q20255", "WBGene00022696", "P46873", "WBGene00003884", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q19633", "WBGene00002222", "species_29420", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "Q17595", "WBGene00001127", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645498": { "compartment": "compartment_18730", "id": "reaction_10645498", "reactome": "R-CEL-5624952", "name": "Assembly of the retrograde IFT train", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645494", "species_10645446", "species_10645410", "species_10645462" ], "products": [ "species_10645496" ], "modifiers": [], "additional_components": [ "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "CHEBI:15996", "Q22799", "WBGene00001005", "P12456", "WBGene00003171", "species_29420", "Q22752", "WBGene00012004", "P34690", "WBGene00006529", "Q21557", "WBGene00010888", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885" ] }, "reaction_10645517": { "compartment": "compartment_18730", "id": "reaction_10645517", "reactome": "R-CEL-5625424", "name": "The retrograde IFT train dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645515" ], "products": [ "species_10645336", "species_10645291", "species_10645216", "species_10645386", "species_10645370" ], "modifiers": [], "additional_components": [ "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18859", "WBGene00016935", "A8DYR7", "WBGene00017973", "Q965T6", "WBGene00002230", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "P46873", "WBGene00003884", "Q20255", "WBGene00022696", "Q22799", "WBGene00001005", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "species_29420", "Q19633", "WBGene00002222", "Q22752", "WBGene00012004", "Q8TA52", "WBGene00022465", "Q93833", "WBGene00000492", "Q18817", "WBGene00000248", "Q0G838", "WBGene00001122", "Q18917", "WBGene00017014", "Q18263", "WBGene00016165", "P52275", "WBGene00006537", "G5ECZ4", "WBGene00001118", "Q7YTJ8", "WBGene00012425", "Q19542", "WBGene00000485", "H2L2E8", "WBGene00006528", "CHEBI:15996", "P90757", "WBGene00000490", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "Q17595", "WBGene00001127", "Q21557", "WBGene00010888", "G5EEE6", "WBGene00002182", "P41937", "WBGene00006538", "G5EFW7", "WBGene00000906", "Q65XS9", "WBGene00043067", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "A0AAC1", "WBGene00012424", "Q19119", "WBGene00006960", "G5ED37", "WBGene00003885", "Q22752", "WBGene00012004", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q19542", "WBGene00000485", "Q18917", "WBGene00017014", "Q65XS9", "WBGene00043067", "Q18263", "WBGene00016165", "A0AAC1", "WBGene00012424", "Q22799", "WBGene00001005", "Q19119", "WBGene00006960", "Q95QT8", "WBGene00001129", "Q6I6D4", "WBGene00001119", "G5EGF0", "WBGene00000484", "G5EDF6", "WBGene00003886", "A8DYR7", "WBGene00017973", "Q22830", "WBGene00003883", "Q8I7G4", "WBGene00001117", "Q9XUC2", "WBGene00012132", "A0A2C9C2L6", "WBGene00016005", "Q8TA52", "WBGene00022465", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q0G838", "WBGene00001122", "G5ED37", "WBGene00003885", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "Q20255", "WBGene00022696", "P90757", "WBGene00000490", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "CHEBI:15996", "P12456", "WBGene00003171" ] }, "reaction_10657713": { "compartment": "compartment_7660", "id": "reaction_10657713", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10657706", "species_10597874" ], "products": [ "species_10657711", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657810": { "compartment": "compartment_7660", "id": "reaction_10657810", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657770", "species_10657787" ], "products": [ "species_10657711", "species_10657808" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "P91853", "WBGene00006732", "Q95XN7", "WBGene00006702", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344" ] }, "reaction_10657815": { "compartment": "compartment_70101", "id": "reaction_10657815", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657717", "species_113592", "species_10597908" ], "products": [ "species_10657721", "species_111294" ], "modifiers": [ [ "species_10657717", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657812": { "compartment": "compartment_7660", "id": "reaction_10657812", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10597874", "species_10657768" ], "products": [ "species_10657770", "species_113541" ], "modifiers": [], "additional_components": [ "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657909": { "compartment": "compartment_70101", "id": "reaction_10657909", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657902" ], "products": [ "species_10601455", "species_10597908" ], "modifiers": [ [ "species_10657906", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00006727", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657821": { "compartment": "compartment_70101", "id": "reaction_10657821", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627924", "species_113592", "species_10597908" ], "products": [ "species_10657723", "species_111294" ], "modifiers": [ [ "species_10627924", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "WBGene00006699" ] }, "reaction_10657818": { "compartment": "compartment_70101", "id": "reaction_10657818", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657723" ], "products": [ "species_10657717", "species_76577" ], "modifiers": [ [ "species_10657723", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657823": { "compartment": "compartment_7660", "id": "reaction_10657823", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657711" ], "products": [ "species_164121", "species_10657768" ], "modifiers": [], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727" ] }, "reaction_10657766": { "compartment": "compartment_70101", "id": "reaction_10657766", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657715", "species_10657721" ], "products": [ "species_10657723", "species_10657764" ], "modifiers": [], "additional_components": [ "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "Q9N2W9", "WBGene00006705", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q17720", "WBGene00006717", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9U1U4", "WBGene00006714", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10629119": { "compartment": "compartment_984", "id": "reaction_10629119", "reactome": "R-CEL-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10629164": { "compartment": "compartment_70101", "id": "reaction_10629164", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10630872": { "compartment": "compartment_70101", "id": "reaction_10630872", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10629166": { "compartment": "compartment_70101", "id": "reaction_10629166", "reactome": "R-CEL-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022", "species_425425" ], "products": [ "species_111627", "species_188972" ], "modifiers": [ [ "species_10629103", "catalyst" ] ], "additional_components": [ "Q58QG8", "WBGene00019844" ] }, "reaction_10660894": { "compartment": "compartment_70101", "id": "reaction_10660894", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660850" ], "products": [ "species_10660892" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10660852": { "compartment": "compartment_70101", "id": "reaction_10660852", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10660848" ], "products": [ "species_10660850" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_8936852", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10661709": { "compartment": "compartment_7660", "id": "reaction_10661709", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658641", "species_10635479" ], "products": [ "species_10661707" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748" ] }, "reaction_10661669": { "compartment": "compartment_7660", "id": "reaction_10661669", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639320", "species_10658641" ], "products": [ "species_10661667" ], "modifiers": [], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00004393", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393", "Q10666", "WBGene00004077" ] }, "reaction_10624784": { "compartment": "compartment_20699", "id": "reaction_10624784", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_744233", "species_113578" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10624776": { "compartment": "compartment_20699", "id": "reaction_10624776", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624779": { "compartment": "compartment_20699", "id": "reaction_10624779", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10624773", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10624768": { "compartment": "compartment_20699", "id": "reaction_10624768", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10624765", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10624732": { "compartment": "compartment_20699", "id": "reaction_10624732", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_109395", "species_727815" ], "modifiers": [ [ "species_10624729", "catalyst" ] ], "additional_components": [ "Q95X47", "WBGene00015038", "Q93890", "WBGene00005153", "O17106", "WBGene00019451", "G5EBK5", "WBGene00018414", "O01879", "WBGene00022577", "O02345", "WBGene00014139" ] }, "reaction_10624786": { "compartment": "compartment_20699", "id": "reaction_10624786", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_744229" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10624781", "catalyst" ] ], "additional_components": [ "species_914003", "species_29410", "species_914003", "species_29410", "WBGene00005025" ] }, "reaction_10624737": { "compartment": "compartment_20699", "id": "reaction_10624737", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10624734", "catalyst" ] ], "additional_components": [ "species_1981137", "species_735700", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10624760": { "compartment": "compartment_20699", "id": "reaction_10624760", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_109402", "species_914003" ], "modifiers": [ [ "species_10624757", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10604090": { "compartment": "compartment_7660", "id": "reaction_10604090", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10604083" ], "products": [ "species_10604087", "species_76230" ], "modifiers": [ [ "species_10604081", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604085": { "compartment": "compartment_7660", "id": "reaction_10604085", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10604081" ], "products": [ "species_10604083" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604745": { "compartment": "compartment_7660", "id": "reaction_10604745", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604079" ], "products": [ "species_10604081" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10604520": { "compartment": "compartment_70101", "id": "reaction_10604520", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604487" ], "products": [ "species_29370", "species_10604517" ], "modifiers": [ [ "species_10604487", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10604524": { "compartment": "compartment_70101", "id": "reaction_10604524", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604517" ], "products": [ "species_10604483", "species_10604515" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10604489": { "compartment": "compartment_70101", "id": "reaction_10604489", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604483", "species_10604485" ], "products": [ "species_10604487" ], "modifiers": [], "additional_components": [ "WBGene00003186", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10599814": { "compartment": "compartment_70101", "id": "reaction_10599814", "reactome": "R-CEL-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10599811", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10622380": { "compartment": "compartment_5460", "id": "reaction_10622380", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10622377", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10666164": { "compartment": "compartment_876", "id": "reaction_10666164", "reactome": "R-CEL-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666158" ], "products": [ "species_10666162" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10646545": { "compartment": "compartment_876", "id": "reaction_10646545", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10608724" ], "products": [ "species_10646543" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "O62422", "WBGene00012532" ] }, "reaction_10640507": { "compartment": "compartment_70101", "id": "reaction_10640507", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640503", "species_10640499" ], "products": [ "species_10640505" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_109496", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "D6VPA1", "WBGene00018976", "Q22038", "WBGene00004357", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438", "species_109496" ] }, "reaction_10663659": { "compartment": "compartment_876", "id": "reaction_10663659", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663655", "species_10605408" ], "products": [ "species_10663657" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "O45628", "WBGene00010433", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "Q9BL72", "WBGene00021698", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q20364", "WBGene00009654", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10665864": { "compartment": "compartment_17906", "id": "reaction_10665864", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665860", "species_10665854" ], "products": [ "species_10665862" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q19848", "WBGene00017895", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "G5EFU0", "WBGene00006443", "species_29438", "Q19848", "WBGene00017895" ] }, "reaction_10665798": { "compartment": "compartment_876", "id": "reaction_10665798", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724" ], "products": [ "species_10665796" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10665839": { "compartment": "compartment_876", "id": "reaction_10665839", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665835", "species_10665808" ], "products": [ "species_10665837" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "B3WFV9", "WBGene00009920", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "Q9U9K0", "WBGene00000072", "G5EEN8", "WBGene00006454", "Q9N589", "WBGene00003475", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O17905", "WBGene00001490", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q21443", "WBGene00003052", "Q23238", "WBGene00006737", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "P10984", "WBGene00000064" ] }, "reaction_10665924": { "compartment": "compartment_876", "id": "reaction_10665924", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10665808" ], "products": [ "species_29372", "species_10665806" ], "modifiers": [ [ "species_10665921", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "P34288", "WBGene00015418", "Q19370", "WBGene00006406", "Q21341", "WBGene00002368", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10663798": { "compartment": "compartment_876", "id": "reaction_10663798", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10635280" ], "products": [ "species_10663796" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356" ] }, "reaction_10646773": { "compartment": "compartment_70101", "id": "reaction_10646773", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646765" ], "products": [ "species_29370", "species_10646770" ], "modifiers": [ [ "species_10618297", "catalyst" ] ], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00003911" ] }, "reaction_10663794": { "compartment": "compartment_876", "id": "reaction_10663794", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663790", "species_10605399" ], "products": [ "species_10663792" ], "modifiers": [], "additional_components": [ "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532", "Q03206", "ced-10", "species_29438", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "A5Z2X2", "WBGene00303007", "P91406", "WBGene00020082", "Q19467", "WBGene00008805", "P03949", "WBGene00000018", "G5EF62", "WBGene00009337", "Q7JP75", "WBGene00000872", "Q17865", "WBGene00007486", "O44518", "WBGene00001579", "Q23146", "WBGene00004271", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q19479", "WBGene00008848", "P46549", "WBGene00002201", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "species_29438", "Q95XW5", "WBGene00021914", "Q27874", "WBGene00003930", "P55163", "WBGene00001580", "O01583", "WBGene00006437", "Q94051", "WBGene00000301", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "Q9N3S5", "WBGene00021635", "Q10929", "WBGene00015146", "K8F807", "WBGene00008750", "Q22682", "WBGene00001622", "Q18685", "WBGene00006836", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "O62422", "WBGene00012532" ] }, "reaction_10665790": { "compartment": "compartment_876", "id": "reaction_10665790", "reactome": "R-CEL-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828" ], "products": [ "species_10646655" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646685": { "compartment": "compartment_70101", "id": "reaction_10646685", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070", "species_10646679" ], "products": [ "species_10646683" ], "modifiers": [], "additional_components": [ "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438", "G5EE56", "WBGene00005077", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645649": { "compartment": "compartment_876", "id": "reaction_10645649", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10612107" ], "products": [ "species_10645644" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10645640": { "compartment": "compartment_70101", "id": "reaction_10645640", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645636", "species_10617721" ], "products": [ "species_10645638" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10636358": { "compartment": "compartment_70101", "id": "reaction_10636358", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635378" ], "products": [ "species_10635374", "species_10635408" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "species_179838", "species_29438", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q05062", "WBGene00000390", "Q10929", "WBGene00015146", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "species_179856", "O62422", "WBGene00012532", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10663835": { "compartment": "compartment_876", "id": "reaction_10663835", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663829", "species_10663831" ], "products": [ "species_10663833" ], "modifiers": [], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "species_29420", "Q05062", "WBGene00000390", "Q20496", "WBGene00004356", "Q94051", "WBGene00000301", "O62422", "WBGene00012532" ] }, "reaction_10663622": { "compartment": "compartment_876", "id": "reaction_10663622", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10645591": { "compartment": "compartment_7660", "id": "reaction_10645591", "reactome": "R-CEL-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645574", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10645588" ], "modifiers": [ [ "species_10645574", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10663868": { "compartment": "compartment_876", "id": "reaction_10663868", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10663860" ], "products": [ "species_29372", "species_10663856" ], "modifiers": [ [ "species_10663865", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "P34288", "WBGene00015418", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10635410": { "compartment": "compartment_70101", "id": "reaction_10635410", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10635408" ], "products": [ "species_10633825" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_29370", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "species_113592", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "P10984", "WBGene00000064" ] }, "reaction_10635825": { "compartment": "compartment_876", "id": "reaction_10635825", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635822" ], "products": [ "species_29370", "species_10635372" ], "modifiers": [ [ "species_10616051", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "WBGene00000018" ] }, "reaction_10665794": { "compartment": "compartment_876", "id": "reaction_10665794", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399" ], "products": [ "species_10665792" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438" ] }, "reaction_10663685": { "compartment": "compartment_70101", "id": "reaction_10663685", "reactome": "R-CEL-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663681", "species_10646828" ], "products": [ "species_10663683" ], "modifiers": [], "additional_components": [ "D6VPA1", "WBGene00018976", "P92199", "WBGene00002694", "Q93332", "WBGene00007954", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "H2KY90", "WBGene00015171", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "O02495", "WBGene00004897", "A0A4V0IKG6", "WBGene00007287", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q09994", "WBGene00019608", "Q17777", "WBGene00007409", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646783": { "compartment": "compartment_70101", "id": "reaction_10646783", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618297", "species_10646779" ], "products": [ "species_10646781" ], "modifiers": [], "additional_components": [ "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10646707": { "compartment": "compartment_70101", "id": "reaction_10646707", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10646703" ], "products": [ "species_10646705" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00016678", "Q22038", "WBGene00004357", "Q09506", "WBGene00016678", "Q17777", "WBGene00007409", "species_29438" ] }, "reaction_10663135": { "compartment": "compartment_70101", "id": "reaction_10663135", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617736", "species_10617721" ], "products": [ "species_10617734", "species_10645758" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10646791": { "compartment": "compartment_70101", "id": "reaction_10646791", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646781" ], "products": [ "species_29370", "species_10618297", "species_10646788" ], "modifiers": [ [ "species_10646781", "catalyst" ] ], "additional_components": [ "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "WBGene00003911", "U4PBJ9", "WBGene00022048", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911" ] }, "reaction_10663863": { "compartment": "compartment_876", "id": "reaction_10663863", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663856" ], "products": [ "species_29420", "species_10663860" ], "modifiers": [ [ "species_10663856", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10663687": { "compartment": "compartment_70101", "id": "reaction_10663687", "reactome": "R-CEL-9013108", "name": "GDIs block activation of RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10646812": { "compartment": "compartment_70101", "id": "reaction_10646812", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646765", "species_10646805" ], "products": [ "species_10646810" ], "modifiers": [], "additional_components": [ "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "WBGene00010109", "Q7YX00", "WBGene00010109", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10663965": { "compartment": "compartment_876", "id": "reaction_10663965", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663957" ], "products": [ "species_10663959" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10664030": { "compartment": "compartment_876", "id": "reaction_10664030", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664027" ], "products": [ "species_10664007", "species_29420" ], "modifiers": [ [ "species_10664027", "catalyst" ] ], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059" ] }, "reaction_10665788": { "compartment": "compartment_74700", "id": "reaction_10665788", "reactome": "R-CEL-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10665784" ], "products": [ "species_10665786" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10664025": { "compartment": "compartment_876", "id": "reaction_10664025", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664007", "species_10664021" ], "products": [ "species_10664023" ], "modifiers": [], "additional_components": [ "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q95YD4", "WBGene00002213", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "Q17796", "WBGene00004101", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "Q20498", "WBGene00009800", "G5EES9", "WBGene00021826", "O01498", "WBGene00004109", "A0A0K3AS36", "Y116A8C.36d", "U4PBY2", "WBGene00002041", "Q9N2Z7", "WBGene00007009", "G5EFU0", "WBGene00006443", "Q95PX0", "WBGene00006410", "H2KY90", "WBGene00015171", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "Q05062", "WBGene00000390", "Q19370", "WBGene00006406", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10646777": { "compartment": "compartment_70101", "id": "reaction_10646777", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10635289" ], "products": [ "species_10646775" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "WBGene00003593", "H2KYX3", "WBGene00003593", "Q17850", "WBGene00003911" ] }, "reaction_10645608": { "compartment": "compartment_7660", "id": "reaction_10645608", "reactome": "R-CEL-5625870", "name": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10645588" ], "products": [ "species_159942", "species_159939", "species_10645605", "species_29478", "species_10628328" ], "modifiers": [ [ "species_10645588", "catalyst" ] ], "additional_components": [ "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10665811": { "compartment": "compartment_876", "id": "reaction_10665811", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665806" ], "products": [ "species_10665808", "species_29420" ], "modifiers": [ [ "species_10665806", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10663849": { "compartment": "compartment_876", "id": "reaction_10663849", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608724", "species_29356" ], "products": [ "species_10663829", "species_29372" ], "modifiers": [ [ "species_10663846", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q86NH1", "WBGene00006363", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10645560": { "compartment": "compartment_7660", "id": "reaction_10645560", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10645540" ], "products": [ "species_113582", "species_10645557" ], "modifiers": [ [ "species_10645540", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10651401": { "compartment": "compartment_1222693", "id": "reaction_10651401", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10651398", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10663703": { "compartment": "compartment_876", "id": "reaction_10663703", "reactome": "R-CEL-9013111", "name": "RHOC GAPs stimulate RHOC GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663700", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "H2KZH5", "WBGene00016971", "Q9XUS9", "WBGene00000875", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10664051": { "compartment": "compartment_876", "id": "reaction_10664051", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10664049" ], "products": [ "species_10664034", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059" ] }, "reaction_10646846": { "compartment": "compartment_876", "id": "reaction_10646846", "reactome": "R-CEL-5671993", "name": "CIT-3 binds DLG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620856", "species_10646842" ], "products": [ "species_10646844" ], "modifiers": [], "additional_components": [ "WBGene00001006", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q03206", "ced-10", "species_29438", "O01583", "WBGene00006437", "G5ECY0", "WBGene00001006" ] }, "reaction_10663131": { "compartment": "compartment_70101", "id": "reaction_10663131", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10663128", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "O01443", "WBGene00015303", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "A0A0K3AW57", "Y75B7AL.4c", "Q23130", "WBGene00012203" ] }, "reaction_10635383": { "compartment": "compartment_70101", "id": "reaction_10635383", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10635372" ], "products": [ "species_29370", "species_10635358" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "A5Z2X2", "WBGene00303007", "Q03206", "ced-10", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "A5Z2X2", "WBGene00303007", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q10929", "WBGene00015146", "species_179838", "species_29438", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10663692": { "compartment": "compartment_70101", "id": "reaction_10663692", "reactome": "R-CEL-9013109", "name": "RHOC GEFs activate RHOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10663689", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10636374": { "compartment": "compartment_70101", "id": "reaction_10636374", "reactome": "R-CEL-2197698", "name": "Src phosphorylate WASP,N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636371", "species_113592" ], "products": [ "species_29370", "species_10635306" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q9N372", "WBGene00021923", "species_29438", "species_179856", "O62422", "WBGene00012532", "WBGene00002213" ] }, "reaction_10646698": { "compartment": "compartment_876", "id": "reaction_10646698", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646694", "species_10617024" ], "products": [ "species_10646696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "WBGene00002996", "Q22038", "WBGene00004357", "Q17777", "WBGene00007409", "species_29438", "A5PEX5", "WBGene00002996" ] }, "reaction_10645075": { "compartment": "compartment_876", "id": "reaction_10645075", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645069", "species_10604443" ], "products": [ "species_10645073" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663754": { "compartment": "compartment_876", "id": "reaction_10663754", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605399", "species_29356" ], "products": [ "species_10635280", "species_29372" ], "modifiers": [ [ "species_10663751", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "species_29420", "Q03206", "ced-10", "H2KZV6", "WBGene00020209", "Q9XVI0", "WBGene00011970", "Q21341", "WBGene00002368", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "G5EDP9", "WBGene00000001", "Q86NH1", "WBGene00006363", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q965N4", "WBGene00015267", "P34288", "WBGene00015418", "U4PAK0", "WBGene00007064", "H2KZV4", "WBGene00017760", "Q19370", "WBGene00006406", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q23130", "WBGene00012203" ] }, "reaction_10665856": { "compartment": "compartment_876", "id": "reaction_10665856", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665854" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10646651": { "compartment": "compartment_70101", "id": "reaction_10646651", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10646643" ], "products": [ "species_10646645" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10666148": { "compartment": "compartment_876", "id": "reaction_10666148", "reactome": "R-CEL-9714363", "name": "RHOC translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408" ], "products": [ "species_10663620" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663963": { "compartment": "compartment_876", "id": "reaction_10663963", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10663959" ], "products": [ "species_10663961" ], "modifiers": [], "additional_components": [ "WBGene00004356", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q20496", "WBGene00004356", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287" ] }, "reaction_10663669": { "compartment": "compartment_70101", "id": "reaction_10663669", "reactome": "R-CEL-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663663", "species_10663661" ], "products": [ "species_10663667" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664047": { "compartment": "compartment_876", "id": "reaction_10664047", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664043", "species_10664034" ], "products": [ "species_10664045" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "Q8I4M6", "WBGene00007840", "O17772", "WBGene00003980", "Q95PX0", "WBGene00006410", "Q21341", "WBGene00002368", "G5EFU0", "WBGene00006443", "Q17850", "WBGene00003911", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "G5EDP9", "WBGene00000001", "Q21408", "WBGene00004951", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "Q9NAN2", "WBGene00003921", "G5EES9", "WBGene00021826", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532", "species_29438", "Q19739", "WBGene00009059", "P34574", "WBGene00011867", "G5EGQ3", "WBGene00003144", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q17850", "WBGene00003911", "Q21408", "WBGene00004951", "Q19467", "WBGene00008805", "E0AHA7", "WBGene00006803", "Q17865", "WBGene00007486", "P46941", "WBGene00008006", "G5EES9", "WBGene00021826", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q22866", "WBGene00002978", "species_29438", "Q19739", "WBGene00009059", "G5EDP9", "WBGene00000001", "A0A1N7SYP3", "WBGene00006876", "P34288", "WBGene00015418", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q9NAN2", "WBGene00003921", "H2KZH5", "WBGene00016971", "Q20398", "WBGene00009678", "O62422", "WBGene00012532" ] }, "reaction_10635380": { "compartment": "compartment_70101", "id": "reaction_10635380", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635376", "species_10620766" ], "products": [ "species_10635378" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064", "species_113592", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "species_179838", "A5Z2X2", "WBGene00303007", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N372", "WBGene00021923", "O44518", "WBGene00001579", "O61861", "WBGene00000205", "Q9XVK6", "WBGene00006958", "Q03206", "ced-10", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q95PX0", "WBGene00006410", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "P55163", "WBGene00001580", "Q05062", "WBGene00000390", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q10929", "WBGene00015146", "species_113592", "species_179856", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10646757": { "compartment": "compartment_70101", "id": "reaction_10646757", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646734" ], "products": [ "species_29370", "species_10646754" ], "modifiers": [ [ "species_10618307", "catalyst" ] ], "additional_components": [ "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "Q20238", "WBGene00009585", "Q20641", "WBGene00003776", "P19626", "WBGene00003370", "Q69Z12", "WBGene00023451", "G5EBY3", "WBGene00003777", "P53014", "WBGene00003371", "Q09510", "WBGene00003372", "Q9XVI9", "WBGene00011734", "P19625", "WBGene00003369", "Q21201", "WBGene00010554", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10640501": { "compartment": "compartment_70101", "id": "reaction_10640501", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640497" ], "products": [ "species_10640499" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00018976", "D6VPA1", "WBGene00018976", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10646808": { "compartment": "compartment_70101", "id": "reaction_10646808", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10646802" ], "products": [ "species_29370", "species_10646805" ], "modifiers": [ [ "species_10645086", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10662944": { "compartment": "compartment_70101", "id": "reaction_10662944", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10662941", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "H2L0P5", "WBGene00022391", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476" ] }, "reaction_10635291": { "compartment": "compartment_70101", "id": "reaction_10635291", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_10617721" ], "products": [ "species_10635282", "species_10617723" ], "modifiers": [ [ "species_10635289", "inhibitor" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "WBGene00003593" ] }, "reaction_10646561": { "compartment": "compartment_70101", "id": "reaction_10646561", "reactome": "R-CEL-5665761", "name": "FMNL3 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646557", "species_10605408" ], "products": [ "species_10646559" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10665870": { "compartment": "compartment_876", "id": "reaction_10665870", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10665868" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663881": { "compartment": "compartment_876", "id": "reaction_10663881", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10663877" ], "products": [ "species_10663879" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "Q22038", "WBGene00004357", "Q9XTB5", "WBGene00002275", "Q7JP75", "WBGene00000872", "Q10956", "WBGene00015148", "species_29438" ] }, "reaction_10663710": { "compartment": "compartment_876", "id": "reaction_10663710", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10663707", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419", "O17905", "WBGene00001490", "A0A0K3AQN0", "WBGene00013682", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "A0A0K3AR51", "F22G12.5c" ] }, "reaction_10646681": { "compartment": "compartment_70101", "id": "reaction_10646681", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646677", "species_10646673" ], "products": [ "species_10646679" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645071": { "compartment": "compartment_876", "id": "reaction_10645071", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645059", "species_10645067" ], "products": [ "species_10645069" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10645765": { "compartment": "compartment_70101", "id": "reaction_10645765", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645762", "species_113592" ], "products": [ "species_29370", "species_10618313", "species_10617721" ], "modifiers": [ [ "species_10645762", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10663883": { "compartment": "compartment_876", "id": "reaction_10663883", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663860" ], "products": [ "species_10646677" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10663698": { "compartment": "compartment_876", "id": "reaction_10663698", "reactome": "R-CEL-9013110", "name": "RHOC binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_10663694" ], "products": [ "species_10663696" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "Q22038", "WBGene00004357", "P92199", "WBGene00002694", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203", "D6VPA1", "WBGene00018976", "Q93332", "WBGene00007954", "O17772", "WBGene00003980", "Q21341", "WBGene00002368", "Q18598", "WBGene00004059", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "Q7JP75", "WBGene00000872", "Q10953", "WBGene00006943", "Q21018", "WBGene00010303", "Q17777", "WBGene00007409", "P92199", "WBGene00002694", "Q22038", "WBGene00004357", "Q9XTZ5", "WBGene00007680", "Q19479", "WBGene00008848", "O44326", "WBGene00001979", "H2KY90", "WBGene00015171", "species_29438", "Q8I103", "WBGene00013683", "Q94051", "WBGene00000301", "O01583", "WBGene00006437", "A0A4V0ILM7", "WBGene00009793", "Q9BL72", "WBGene00021698", "A0A4V0IKG6", "WBGene00007287", "Q09994", "WBGene00019608", "P34489", "WBGene00010453", "H2KZH5", "WBGene00016971", "Q19958", "WBGene00006064", "Q23130", "WBGene00012203" ] }, "reaction_10646549": { "compartment": "compartment_876", "id": "reaction_10646549", "reactome": "R-CEL-5665748", "name": "FMNL2 binds RHOC:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646541", "species_10605408" ], "products": [ "species_10646547" ], "modifiers": [], "additional_components": [ "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698" ] }, "reaction_10646669": { "compartment": "compartment_70101", "id": "reaction_10646669", "reactome": "R-CEL-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646655", "species_10646665" ], "products": [ "species_10646667" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "species_29438" ] }, "reaction_10645646": { "compartment": "compartment_70101", "id": "reaction_10645646", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645638", "species_10620766" ], "products": [ "species_10645642" ], "modifiers": [ [ "species_10645644", "inhibitor" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_29438", "O62422", "WBGene00012532", "species_113592", "P10984", "WBGene00000064", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O17772", "WBGene00003980", "species_113592", "species_29438", "P10984", "WBGene00000064", "O62422", "WBGene00012532", "Q03206", "ced-10", "Q94288", "WBGene00000287", "O17772", "WBGene00003980", "Q18136", "WBGene00006861", "species_74016", "species_29438", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q05062", "WBGene00000390", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O62422", "WBGene00012532" ] }, "reaction_10665850": { "compartment": "compartment_70101", "id": "reaction_10665850", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665846", "species_10663860" ], "products": [ "species_10665848" ], "modifiers": [], "additional_components": [ "B3WFV9", "WBGene00009920", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203", "Q22038", "WBGene00004357", "species_29438", "B3WFV9", "WBGene00009920", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q19479", "WBGene00008848", "P34686", "WBGene00000293", "O45657", "WBGene00004048", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "species_29438", "Q23158", "WBGene00000228", "Q94051", "WBGene00000301", "O02495", "WBGene00004897", "A0A679L8R0", "WBGene00020443", "O02163", "WBGene00020376", "Q7JP75", "WBGene00000872", "Q9XUT0", "WBGene00010664", "Q21443", "WBGene00003052", "Q9U2A6", "WBGene00012980", "Q22422", "WBGene00001577", "Q7K7J0", "WBGene00001575", "Q23146", "WBGene00004271", "Q23130", "WBGene00012203" ] }, "reaction_10645755": { "compartment": "compartment_13949", "id": "reaction_10645755", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645739" ], "products": [ "species_10645753" ], "modifiers": [ [ "species_10645739", "catalyst" ] ], "additional_components": [ "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10663674": { "compartment": "compartment_70101", "id": "reaction_10663674", "reactome": "R-CEL-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646828", "species_29356" ], "products": [ "species_10663661", "species_29372" ], "modifiers": [ [ "species_10663671", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "H2KZV6", "WBGene00020209", "Q21341", "WBGene00002368", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "G5EDP9", "WBGene00000001", "Q9XUS9", "WBGene00000875", "H2KZH5", "WBGene00016971", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203" ] }, "reaction_10663133": { "compartment": "compartment_70101", "id": "reaction_10663133", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617740", "species_10617721" ], "products": [ "species_10645760", "species_10617738" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10665919": { "compartment": "compartment_20699", "id": "reaction_10665919", "reactome": "R-CEL-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665915", "species_10665868" ], "products": [ "species_10665917" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q95QQ9", "WBGene00016792", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "Q19989", "WBGene00018017" ] }, "reaction_10645095": { "compartment": "compartment_70101", "id": "reaction_10645095", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645073" ], "products": [ "species_29370", "species_10645067", "species_10604443", "species_10645086" ], "modifiers": [ [ "species_10645073", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "WBGene00009793", "Q22038", "WBGene00004357", "Q03206", "ced-10", "Q9UA62", "WBGene00021022", "species_179838", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10663842": { "compartment": "compartment_876", "id": "reaction_10663842", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663829" ], "products": [ "species_10608724", "species_29420" ], "modifiers": [ [ "species_10663839", "catalyst" ] ], "additional_components": [ "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "H2KYI7", "WBGene00006496", "Q20487", "WBGene00018520", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "G5ECK4", "WBGene00044989", "Q19572", "WBGene00001674", "O17905", "WBGene00001490", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "A0A0K3AR51", "F22G12.5c", "X5LV34", "WBGene00001366", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10663679": { "compartment": "compartment_876", "id": "reaction_10663679", "reactome": "R-CEL-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10663661" ], "products": [ "species_10646828", "species_29420" ], "modifiers": [ [ "species_10663676", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q45FX5", "WBGene00006887", "H2L0P5", "WBGene00022391", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10663618": { "compartment": "compartment_70101", "id": "reaction_10663618", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663610", "species_10605406" ], "products": [ "species_10663616" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q20496", "WBGene00004356" ] }, "reaction_10664000": { "compartment": "compartment_876", "id": "reaction_10664000", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663996", "species_10663959" ], "products": [ "species_10663998" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29438", "Q94124", "WBGene00004287", "G5EE56", "WBGene00005077", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q93332", "WBGene00007954", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q09582", "WBGene00010988", "Q94124", "WBGene00004287", "Q9N2W5", "WBGene00022381", "O02495", "WBGene00004897", "Q18825", "WBGene00000238", "P91406", "WBGene00020082", "P54812", "WBGene00008053", "P34492", "WBGene00019301", "Q10953", "WBGene00006943", "G5ECJ6", "WBGene00000812", "Q18462", "WBGene00016416", "H2KZ40", "WBGene00022459", "Q23146", "WBGene00004271", "B3WFV9", "WBGene00009920", "Q03206", "ced-10", "V6CLC2", "WBGene00021209", "O44326", "WBGene00001979", "G5EFU0", "WBGene00006443", "H2KY90", "WBGene00015171", "H2L2E8", "WBGene00006528", "species_29438", "Q94051", "WBGene00000301", "O62219", "WBGene00009366", "P34690", "WBGene00006529", "Q23571", "WBGene00014054", "Q9BL44", "WBGene00022177", "Q22682", "WBGene00001622", "Q9XUT0", "WBGene00010664", "Q19958", "WBGene00006064" ] }, "reaction_10666146": { "compartment": "compartment_12045", "id": "reaction_10666146", "reactome": "R-CEL-9714361", "name": "RHOC activates endoplasmic reticulum effectors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666142", "species_10663620" ], "products": [ "species_10666144" ], "modifiers": [], "additional_components": [ "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "Q95XR9", "WBGene00022546", "Q20981", "WBGene00022546", "O17099", "WBGene00022546", "O01630", "WBGene00022546", "Q20797", "WBGene00006373", "P91330", "WBGene00022546", "O44782", "WBGene00018008", "species_29438", "P91915", "WBGene00022546", "G5EDE8", "WBGene00002070", "P91193", "WBGene00017066" ] }, "reaction_10645593": { "compartment": "compartment_7660", "id": "reaction_10645593", "reactome": "R-CEL-5625849", "name": "Demethylase KDM1A binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645572", "species_10628328" ], "products": [ "species_10645574" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117", "WBGene00000138", "Q9XXU5", "WBGene00000138", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "species_193079", "P04255", "WBGene00001885", "species_193057", "A0A4V0ILM7", "WBGene00009793", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "species_469662", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "CHEBI:29117" ] }, "reaction_10646582": { "compartment": "compartment_876", "id": "reaction_10646582", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646573", "species_10646578" ], "products": [ "species_10646580" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698", "WBGene00006406", "Q03206", "ced-10", "Q19370", "WBGene00006406", "species_113592", "species_29438", "P10984", "WBGene00000064", "Q9BL72", "WBGene00021698" ] }, "reaction_10650007": { "compartment": "compartment_70101", "id": "reaction_10650007", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628563" ], "products": [ "species_10628579" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663391": { "compartment": "compartment_70101", "id": "reaction_10663391", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663357" ], "products": [ "species_10663389" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663332": { "compartment": "compartment_70101", "id": "reaction_10663332", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663320" ], "products": [ "species_10663330" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625371": { "compartment": "compartment_70101", "id": "reaction_10625371", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613343", "species_10625343" ], "products": [ "species_10625369" ], "modifiers": [], "additional_components": [ "WBGene00006887", "WBGene00004829", "Q19019", "WBGene00004829", "Q45FX5", "WBGene00006887" ] }, "reaction_10663909": { "compartment": "compartment_984", "id": "reaction_10663909", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622329", "species_10663905" ], "products": [ "species_10663907" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q20024", "WBGene00006371", "O16000", "WBGene00006798", "P91409", "WBGene00006374", "Q22666", "WBGene00011917" ] }, "reaction_10625148": { "compartment": "compartment_70101", "id": "reaction_10625148", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623793", "species_10625144", "species_10608624", "species_10602400" ], "products": [ "species_10625146" ], "modifiers": [], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q18462", "WBGene00016416", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10650185": { "compartment": "compartment_70101", "id": "reaction_10650185", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650179" ], "products": [ "species_10650183" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10625379": { "compartment": "compartment_70101", "id": "reaction_10625379", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617312", "species_10625343" ], "products": [ "species_10625373" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10625367": { "compartment": "compartment_70101", "id": "reaction_10625367", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625350", "species_10625345" ], "products": [ "species_10625365" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q18462", "WBGene00016416" ] }, "reaction_10622343": { "compartment": "compartment_984", "id": "reaction_10622343", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10622329" ], "products": [ "species_10622331" ], "modifiers": [ [ "species_10622341", "inhibitor" ] ], "additional_components": [ "WBGene00006798", "WBGene00011917", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O44412", "WBGene00020298", "A5PEW5", "WBGene00004364", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10663421": { "compartment": "compartment_984", "id": "reaction_10663421", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10663322": { "compartment": "compartment_70101", "id": "reaction_10663322", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310", "species_10663269" ], "products": [ "species_10663320" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650009": { "compartment": "compartment_70101", "id": "reaction_10650009", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628559" ], "products": [ "species_10628563" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650236": { "compartment": "compartment_70101", "id": "reaction_10650236", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650183" ], "products": [ "species_10650234" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663381": { "compartment": "compartment_70101", "id": "reaction_10663381", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663365" ], "products": [ "species_10663367" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663314": { "compartment": "compartment_70101", "id": "reaction_10663314", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663310" ], "products": [ "species_10663312" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663482": { "compartment": "compartment_70101", "id": "reaction_10663482", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617052" ], "products": [ "species_29370", "species_10663269" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650353": { "compartment": "compartment_70101", "id": "reaction_10650353", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650347" ], "products": [ "species_10650351" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663318": { "compartment": "compartment_70101", "id": "reaction_10663318", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663263" ], "products": [ "species_10663316" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663377": { "compartment": "compartment_70101", "id": "reaction_10663377", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663367" ], "products": [ "species_10663375" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10663359": { "compartment": "compartment_70101", "id": "reaction_10663359", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661639" ], "products": [ "species_10663357" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10650349": { "compartment": "compartment_70101", "id": "reaction_10650349", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650345" ], "products": [ "species_10650347" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628569": { "compartment": "compartment_70101", "id": "reaction_10628569", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628561" ], "products": [ "species_10628567" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10628583": { "compartment": "compartment_70101", "id": "reaction_10628583", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628567" ], "products": [ "species_10628581" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10622841": { "compartment": "compartment_70101", "id": "reaction_10622841", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622832" ], "products": [ "species_10622838" ], "modifiers": [ [ "species_10622832", "catalyst" ] ], "additional_components": [ "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "P0CG71", "WBGene00006727" ] }, "reaction_10625377": { "compartment": "compartment_70101", "id": "reaction_10625377", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625373", "species_10607816" ], "products": [ "species_10625375" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238", "WBGene00021320", "Q9NHC3", "WBGene00000416", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q95XA9", "WBGene00021238" ] }, "reaction_10650548": { "compartment": "compartment_17957", "id": "reaction_10650548", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10650546" ], "modifiers": [ [ "species_10628579", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10636285": { "compartment": "compartment_7660", "id": "reaction_10636285", "reactome": "R-CEL-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636283" ], "products": [], "modifiers": [], "additional_components": [ "G5EDM7", "WBGene00000901", "P0CG71", "WBGene00006727" ] }, "reaction_10607909": { "compartment": "compartment_7660", "id": "reaction_10607909", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10636243": { "compartment": "compartment_7660", "id": "reaction_10636243", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636237", "species_10597874" ], "products": [ "species_10636235", "species_10636241" ], "modifiers": [], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00006727", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636145": { "compartment": "compartment_876", "id": "reaction_10636145", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636143" ], "products": [], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "G5EDS9", "WBGene00006445", "P20792", "WBGene00000897", "P0CG71", "WBGene00006727" ] }, "reaction_10636343": { "compartment": "compartment_70101", "id": "reaction_10636343", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636336" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727" ] }, "reaction_10635812": { "compartment": "compartment_7660", "id": "reaction_10635812", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607873", "species_10635808" ], "products": [ "species_10635810" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "Q21733", "WBGene00000904", "G5EDT1", "WBGene00003020", "F5GUE5", "WBGene00000910", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "P45897", "WBGene00004858", "G5EF11", "WBGene00001161" ] }, "reaction_10635466": { "compartment": "compartment_70101", "id": "reaction_10635466", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10607745" ], "products": [ "species_10635464" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10607715" ], "products": [ "species_10607745" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10642987": { "compartment": "compartment_13231", "id": "reaction_10642987", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642983", "species_10600633" ], "products": [ "species_10642985" ], "modifiers": [], "additional_components": [ "WBGene00010117", "WBGene00004806", "Q9XUY5", "WBGene00010117", "Q22836", "WBGene00004806" ] }, "reaction_10641008": { "compartment": "compartment_876", "id": "reaction_10641008", "reactome": "R-CEL-4332235", "name": "CBL binds TGFBR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607752", "species_10608624" ], "products": [ "species_10641006" ], "modifiers": [], "additional_components": [ "WBGene00000900", "WBGene00004829", "P50488", "WBGene00000900", "Q19019", "WBGene00004829" ] }, "reaction_10636347": { "compartment": "compartment_70101", "id": "reaction_10636347", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613620" ], "products": [ "species_10607792" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636330": { "compartment": "compartment_7660", "id": "reaction_10636330", "reactome": "R-CEL-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10636312" ], "products": [ "species_10636327", "species_427497", "species_10636310" ], "modifiers": [ [ "species_10636312", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10625009": { "compartment": "compartment_7660", "id": "reaction_10625009", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625005" ], "products": [ "species_10625007" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10636339": { "compartment": "compartment_70101", "id": "reaction_10636339", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636334", "species_10597908" ], "products": [ "species_10627446", "species_10636336" ], "modifiers": [ [ "species_10636334", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500", "WBGene00006727", "WBGene00000500", "Q21733", "WBGene00000904", "P0CG71", "WBGene00006727", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10607797": { "compartment": "compartment_171062", "id": "reaction_10607797", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607794", "species_113592" ], "products": [ "species_29370", "species_10607778" ], "modifiers": [ [ "species_10607794", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636345": { "compartment": "compartment_7660", "id": "reaction_10636345", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613608", "species_10607873" ], "products": [ "species_10613610" ], "modifiers": [], "additional_components": [ "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636356": { "compartment": "compartment_70101", "id": "reaction_10636356", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607737", "species_10636349" ], "products": [ "species_10636351" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636305": { "compartment": "compartment_7660", "id": "reaction_10636305", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636301", "species_10607873" ], "products": [ "species_10636303" ], "modifiers": [], "additional_components": [ "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q9XW26", "WBGene00012735", "Q22678", "WBGene00011926", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636332": { "compartment": "compartment_7660", "id": "reaction_10636332", "reactome": "R-CEL-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636310", "species_10607873" ], "products": [ "species_10636312" ], "modifiers": [], "additional_components": [ "WBGene00004049", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q9N4H4", "WBGene00004049", "P45897", "WBGene00004858" ] }, "reaction_10607782": { "compartment": "compartment_17941", "id": "reaction_10607782", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607778" ], "products": [ "species_10607737", "species_10607780" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897" ] }, "reaction_10636289": { "compartment": "compartment_7660", "id": "reaction_10636289", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636287" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P0CG71", "WBGene00006727" ] }, "reaction_10607888": { "compartment": "compartment_70101", "id": "reaction_10607888", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607873" ], "modifiers": [ [ "species_10607886", "inhibitor" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10635770": { "compartment": "compartment_70101", "id": "reaction_10635770", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635464" ], "products": [ "species_10635768" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q19404", "WBGene00008748", "P45897", "WBGene00004858" ] }, "reaction_10636354": { "compartment": "compartment_70101", "id": "reaction_10636354", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636351", "species_29356" ], "products": [ "species_10636349", "species_10607792", "species_29372" ], "modifiers": [ [ "species_10636351", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910" ] }, "reaction_10636207": { "compartment": "compartment_70101", "id": "reaction_10636207", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636205" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P0CG71", "WBGene00006727" ] }, "reaction_10636239": { "compartment": "compartment_7660", "id": "reaction_10636239", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636226", "species_10636235" ], "products": [ "species_10636237" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858" ] }, "reaction_10636341": { "compartment": "compartment_70101", "id": "reaction_10636341", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627446", "species_10607790" ], "products": [ "species_10636334" ], "modifiers": [], "additional_components": [ "WBGene00000500", "WBGene00000904", "Q21733", "WBGene00000904", "G5ECY6", "WBGene00000500" ] }, "reaction_10636233": { "compartment": "compartment_7660", "id": "reaction_10636233", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607873" ], "products": [ "species_113582", "species_10636226" ], "modifiers": [ [ "species_10636230", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "O17869", "WBGene00009650", "Q9TYP2", "WBGene00000506", "P34425", "WBGene00000507", "P90866", "WBGene00000409", "Q9TVL3", "WBGene00000410" ] }, "reaction_10613623": { "compartment": "compartment_7660", "id": "reaction_10613623", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10613610" ], "products": [ "species_10613620", "species_113550", "species_10607859", "species_10613608" ], "modifiers": [ [ "species_10613610", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "WBGene00004858", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460", "Q21733", "WBGene00000904", "G5EEM6", "WBGene00006524", "F5GUE5", "WBGene00000910", "Q19775", "WBGene00006460", "P45897", "WBGene00004858" ] }, "reaction_10636245": { "compartment": "compartment_7660", "id": "reaction_10636245", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636241" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "P0CG71", "WBGene00006727" ] }, "reaction_10640756": { "compartment": "compartment_876", "id": "reaction_10640756", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640622", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640625": { "compartment": "compartment_876", "id": "reaction_10640625", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640620" ], "products": [ "species_29370", "species_10640622" ], "modifiers": [ [ "species_10640620", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10640831": { "compartment": "compartment_876", "id": "reaction_10640831", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640828", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "O01847", "WBGene00015704", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q19475", "WBGene00001164" ] }, "reaction_10633379": { "compartment": "compartment_161320", "id": "reaction_10633379", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10635744": { "compartment": "compartment_20699", "id": "reaction_10635744", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635741", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q9TZK5", "WBGene00002030", "Q4TTA0", "WBGene00044303" ] }, "reaction_10634068": { "compartment": "compartment_20699", "id": "reaction_10634068", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10633892" ], "products": [ "species_205687", "species_10634052" ], "modifiers": [ [ "species_10634065", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005021" ] }, "reaction_10634930": { "compartment": "compartment_876", "id": "reaction_10634930", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633349" ], "products": [ "species_10633006" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10635710": { "compartment": "compartment_17963", "id": "reaction_10635710", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634986", "species_741440" ], "products": [ "species_10635014", "species_742343" ], "modifiers": [ [ "species_10635705", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10632896": { "compartment": "compartment_161320", "id": "reaction_10632896", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10634893": { "compartment": "compartment_20699", "id": "reaction_10634893", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634851", "species_741440" ], "products": [ "species_10634879", "species_742343" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10635730": { "compartment": "compartment_20699", "id": "reaction_10635730", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10634958" ], "products": [ "species_10634986", "species_742343" ], "modifiers": [ [ "species_10635727", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002029" ] }, "reaction_10635764": { "compartment": "compartment_161320", "id": "reaction_10635764", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10632794": { "compartment": "compartment_161320", "id": "reaction_10632794", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10634060": { "compartment": "compartment_20699", "id": "reaction_10634060", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10634052" ], "products": [ "species_10633930", "species_205687" ], "modifiers": [ [ "species_10634057", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005020" ] }, "reaction_10633424": { "compartment": "compartment_161320", "id": "reaction_10633424", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065212", "species_1605715" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10633421", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10665103": { "compartment": "compartment_20699", "id": "reaction_10665103", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634019", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q09363", "WBGene00005026", "species_266099" ] }, "reaction_10634024": { "compartment": "compartment_20699", "id": "reaction_10634024", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633930", "species_1889970" ], "products": [ "species_205687", "species_10633958" ], "modifiers": [ [ "species_10634021", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "O62113", "WBGene00008160", "Q9XU73", "WBGene00011781", "O02304", "WBGene00011650", "O17708", "WBGene00008293", "Q09363", "WBGene00005026", "A0A0K3AUF6", "W07G9.2b", "species_266099", "O17751", "WBGene00008479" ] }, "reaction_10633902": { "compartment": "compartment_20699", "id": "reaction_10633902", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10633864" ], "products": [ "species_10633892", "species_205687" ], "modifiers": [ [ "species_10633897", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00005024" ] }, "reaction_10665106": { "compartment": "compartment_161320", "id": "reaction_10665106", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10635766": { "compartment": "compartment_161320", "id": "reaction_10635766", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10636009": { "compartment": "compartment_876", "id": "reaction_10636009", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10635722": { "compartment": "compartment_20699", "id": "reaction_10635722", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635042", "species_741440" ], "products": [ "species_742343", "species_10635064" ], "modifiers": [ [ "species_10635715", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002031" ] }, "reaction_10635180": { "compartment": "compartment_17963", "id": "reaction_10635180", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635066" ], "products": [ "species_10635178" ], "modifiers": [], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749" ] }, "reaction_10665110": { "compartment": "compartment_161320", "id": "reaction_10665110", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10632601", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10633440": { "compartment": "compartment_161320", "id": "reaction_10633440", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10633435", "catalyst" ] ], "additional_components": [ "CHEBI:63513", "CHEBI:63511", "CHEBI:63512", "CHEBI:63515", "WBGene00011923" ] }, "reaction_10635762": { "compartment": "compartment_161320", "id": "reaction_10635762", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10633376", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10634924": { "compartment": "compartment_20699", "id": "reaction_10634924", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634921", "species_2022884" ], "products": [ "species_10634851", "species_2022890" ], "modifiers": [ [ "species_10634884", "catalyst" ] ], "additional_components": [ "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "Q06561", "WBGene00006787", "G5EGU4", "WBGene00001687", "G5ECV3", "WBGene00007284", "Q18530", "WBGene00003056", "O44565", "WBGene00002247", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10646062": { "compartment": "compartment_7660", "id": "reaction_10646062", "reactome": "R-CEL-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10646052" ], "products": [ "species_10646054", "species_5651834" ], "modifiers": [ [ "species_10646059", "catalyst" ] ], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "WBGene00004051" ] }, "reaction_10606556": { "compartment": "compartment_5460", "id": "reaction_10606556", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10606552" ], "products": [ "species_10606554" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10606439": { "compartment": "compartment_70101", "id": "reaction_10606439", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10606436", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10604420": { "compartment": "compartment_70101", "id": "reaction_10604420", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10604417", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "E6N0V1", "WBGene00018819", "Q10656", "WBGene00001184", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10604454": { "compartment": "compartment_70101", "id": "reaction_10604454", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604434" ], "products": [ "species_29370", "species_10604451" ], "modifiers": [ [ "species_10604443", "catalyst" ] ], "additional_components": [ "species_179838", "Q17941", "WBGene00000102", "species_179838", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604445": { "compartment": "compartment_876", "id": "reaction_10604445", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604441" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10604436": { "compartment": "compartment_876", "id": "reaction_10604436", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10604432" ], "products": [ "species_10604434", "species_10604425" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "G5EED4", "WBGene00010700", "species_179838", "Q17941", "WBGene00000102", "WBGene00010700" ] }, "reaction_10610560": { "compartment": "compartment_876", "id": "reaction_10610560", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605406" ], "products": [ "species_10605408" ], "modifiers": [ [ "species_10610557", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10619825": { "compartment": "compartment_7660", "id": "reaction_10619825", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619821", "species_10619819" ], "products": [ "species_10619823" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "WBGene00023409", "Q27894", "WBGene00001878", "G5ECR1", "WBGene00023409", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619863": { "compartment": "compartment_7660", "id": "reaction_10619863", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_77087" ], "products": [ "species_10602565", "species_77502" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619860": { "compartment": "compartment_7660", "id": "reaction_10619860", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10619843" ], "products": [ "species_10614288", "species_427498", "species_427497" ], "modifiers": [ [ "species_10619857", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O44410", "WBGene00020296", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21921", "WBGene00004800", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10641870": { "compartment": "compartment_7660", "id": "reaction_10641870", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641868" ], "products": [ "species_10641841", "species_10641860", "species_10641866" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642922": { "compartment": "compartment_7660", "id": "reaction_10642922", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10642887" ], "products": [ "species_113550", "species_10642907", "species_10642885" ], "modifiers": [ [ "species_10642919", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "WBGene00018328", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641839": { "compartment": "compartment_7660", "id": "reaction_10641839", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641817" ], "modifiers": [ [ "species_10641836", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10641843": { "compartment": "compartment_7660", "id": "reaction_10641843", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641841" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639827": { "compartment": "compartment_70101", "id": "reaction_10639827", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639821" ], "products": [ "species_10639825" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10642845": { "compartment": "compartment_70101", "id": "reaction_10642845", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642788", "species_10642841" ], "products": [ "species_10642843" ], "modifiers": [], "additional_components": [ "WBGene00018328", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250" ] }, "reaction_10641858": { "compartment": "compartment_7660", "id": "reaction_10641858", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_29358" ], "products": [ "species_113582", "species_10641822" ], "modifiers": [ [ "species_10641855", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583" ] }, "reaction_10639846": { "compartment": "compartment_7660", "id": "reaction_10639846", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10639841" ], "products": [ "species_113582", "species_10639835" ], "modifiers": [ [ "species_10639843", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000227" ] }, "reaction_10643043": { "compartment": "compartment_70101", "id": "reaction_10643043", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10643038" ], "products": [ "species_10639783", "species_10614711", "species_10643040", "species_10639865" ], "modifiers": [ [ "species_10643038", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q9U266", "WBGene00001838", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "Q9U266", "WBGene00001838" ] }, "reaction_10639788": { "compartment": "compartment_70101", "id": "reaction_10639788", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639786" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10639869": { "compartment": "compartment_70101", "id": "reaction_10639869", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639867" ], "products": [ "species_10639783", "species_10614711", "species_10639865" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10642951": { "compartment": "compartment_70101", "id": "reaction_10642951", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642841", "species_29356" ], "products": [ "species_10642942", "species_29372" ], "modifiers": [ [ "species_10642948", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10641824": { "compartment": "compartment_7660", "id": "reaction_10641824", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641729" ], "products": [ "species_10641812" ], "modifiers": [ [ "species_10641822", "catalyst" ], [ "species_10641817", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EC99", "WBGene00008714", "G5EE36", "WBGene00002013", "Q9U3B7", "WBGene00002002", "Q20363", "WBGene00004798", "G5EE65", "WBGene00011906", "P34696", "WBGene00002015", "Q17849", "WBGene00002023", "G5EF99", "WBGene00014233", "B0M0L8", "WBGene00002024", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "Q19227", "WBGene00014233", "P02513", "WBGene00002019", "P06581", "WBGene00002018", "P06582", "WBGene00002016", "Q20660", "WBGene00002021", "Q20164", "WBGene00002012", "P34328", "WBGene00002011", "Q19228", "WBGene00014233", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10639832": { "compartment": "compartment_70101", "id": "reaction_10639832", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10639830" ], "modifiers": [ [ "species_10607886", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10641668": { "compartment": "compartment_70101", "id": "reaction_10641668", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783", "species_113592" ], "products": [ "species_29370", "species_10641665" ], "modifiers": [ [ "species_10609552", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10639859": { "compartment": "compartment_7660", "id": "reaction_10639859", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639825", "species_10639855" ], "products": [ "species_10639857" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10639877": { "compartment": "compartment_70101", "id": "reaction_10639877", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639783" ], "products": [ "species_10639821" ], "modifiers": [ [ "species_10605919", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10642990": { "compartment": "compartment_70101", "id": "reaction_10642990", "reactome": "R-CEL-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642843" ], "products": [ "species_10642887" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "K8ERU5", "WBGene00018328", "Q05036", "WBGene00016250", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10643016": { "compartment": "compartment_70101", "id": "reaction_10643016", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642942", "species_113592" ], "products": [ "species_29370", "species_10642841" ], "modifiers": [ [ "species_10643006", "catalyst" ], [ "species_10643014", "inhibitor" ] ], "additional_components": [ "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_29370", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "P11141", "WBGene00002010", "G5ECU5", "WBGene00009691", "P27420", "WBGene00002007", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "O45246", "WBGene00002026", "species_113592", "Q20752", "WBGene00006059", "Q05036", "WBGene00016250", "O61980", "WBGene00006760", "O44739", "WBGene00000236", "Q05036", "WBGene00016250", "G5EE04", "WBGene00011735" ] }, "reaction_10639839": { "compartment": "compartment_7660", "id": "reaction_10639839", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639835", "species_10619855" ], "products": [ "species_10639837" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10631172": { "compartment": "compartment_70616", "id": "reaction_10631172", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10631169", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10640468": { "compartment": "compartment_984", "id": "reaction_10640468", "reactome": "R-CEL-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10640457", "species_10640455" ], "modifiers": [ [ "species_10640465", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q9BL26", "WBGene00044760", "Q20176", "WBGene00003555" ] }, "reaction_10632241": { "compartment": "compartment_876", "id": "reaction_10632241", "reactome": "R-CEL-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237", "species_10631688" ], "products": [ "species_10632239" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631553": { "compartment": "compartment_984", "id": "reaction_10631553", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631532" ], "products": [ "species_10630560", "species_10631550" ], "modifiers": [ [ "species_10631532", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632145": { "compartment": "compartment_984", "id": "reaction_10632145", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631644" ], "products": [ "species_10631571", "species_10632142" ], "modifiers": [ [ "species_10631644", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632289": { "compartment": "compartment_876", "id": "reaction_10632289", "reactome": "R-CEL-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632239" ], "products": [ "species_10632266", "species_10632259" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637134": { "compartment": "compartment_876", "id": "reaction_10637134", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10615940": { "compartment": "compartment_984", "id": "reaction_10615940", "reactome": "R-CEL-375135", "name": "Basigin binds Matrix metalloproteinase-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615936" ], "products": [ "species_10615938" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "Q8MQ86", "WBGene00017184", "G5ECC4", "WBGene00020646", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10661241": { "compartment": "compartment_984", "id": "reaction_10661241", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661234", "species_10661236" ], "modifiers": [ [ "species_10630560", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10661248": { "compartment": "compartment_984", "id": "reaction_10661248", "reactome": "R-CEL-8940561", "name": "MMP7 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661243", "species_10661238", "species_10661245", "species_10661236" ], "modifiers": [ [ "species_10630596", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632526": { "compartment": "compartment_984", "id": "reaction_10632526", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632524", "species_10632425" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632314": { "compartment": "compartment_984", "id": "reaction_10632314", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631880" ], "products": [ "species_10632312", "species_10630632" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632506": { "compartment": "compartment_984", "id": "reaction_10632506", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632183" ], "products": [ "species_10632407", "species_10632504" ], "modifiers": [ [ "species_10632286", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632165": { "compartment": "compartment_17963", "id": "reaction_10632165", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632163" ], "products": [ "species_10631589" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10632547": { "compartment": "compartment_984", "id": "reaction_10632547", "reactome": "R-CEL-1604763", "name": "Autocatalytic activation of MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632332" ], "products": [ "species_10632544", "species_10630596" ], "modifiers": [ [ "species_10632332", "catalyst" ], [ "species_1604783", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "CHEBI:24505", "species_444761" ] }, "reaction_10661268": { "compartment": "compartment_984", "id": "reaction_10661268", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661232" ], "products": [ "species_10661238", "species_10661265" ], "modifiers": [ [ "species_10630542", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640453": { "compartment": "compartment_984", "id": "reaction_10640453", "reactome": "R-CEL-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636728" ], "products": [ "species_10640444", "species_10640450" ], "modifiers": [ [ "species_10631487", "catalyst" ] ], "additional_components": [ "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "O44191", "WBGene00004374", "G5EFK8", "WBGene00008779", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632486": { "compartment": "compartment_984", "id": "reaction_10632486", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632427" ], "products": [ "species_10632483", "species_10630542" ], "modifiers": [ [ "species_10632427", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640402": { "compartment": "compartment_876", "id": "reaction_10640402", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10640377" ], "modifiers": [ [ "species_10640399", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDW5", "WBGene00000074", "Q19844", "WBGene00017865", "G5EFD5", "WBGene00006804", "Q9N5X7", "WBGene00016423" ] }, "reaction_10649493": { "compartment": "compartment_5460", "id": "reaction_10649493", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696409" ], "products": [ "species_113556", "species_113548", "species_5693978" ], "modifiers": [ [ "species_10649490", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10632389": { "compartment": "compartment_984", "id": "reaction_10632389", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631787" ], "products": [ "species_10632386", "species_10630578" ], "modifiers": [ [ "species_10631787", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631453": { "compartment": "compartment_984", "id": "reaction_10631453", "reactome": "R-CEL-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430" ], "products": [ "species_10630506" ], "modifiers": [ [ "species_10631450", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632264": { "compartment": "compartment_984", "id": "reaction_10632264", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632237" ], "products": [ "species_10632259", "species_10631532" ], "modifiers": [ [ "species_10632261", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631751": { "compartment": "compartment_984", "id": "reaction_10631751", "reactome": "R-CEL-1592362", "name": "Activation of proMMP7 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631708" ], "products": [ "species_10630596", "species_10631726" ], "modifiers": [ [ "species_10631748", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632124": { "compartment": "compartment_17963", "id": "reaction_10632124", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632044" ], "products": [ "species_10632122" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10631903": { "compartment": "compartment_984", "id": "reaction_10631903", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631862" ], "products": [ "species_10631898", "species_10631880" ], "modifiers": [ [ "species_10631900", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631945": { "compartment": "compartment_984", "id": "reaction_10631945", "reactome": "R-CEL-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623212", "species_10631862" ], "products": [ "species_10631943" ], "modifiers": [], "additional_components": [ "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631594": { "compartment": "compartment_984", "id": "reaction_10631594", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631571" ], "products": [ "species_10615936" ], "modifiers": [ [ "species_10631591", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10630637": { "compartment": "compartment_984", "id": "reaction_10630637", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630506" ], "products": [], "modifiers": [ [ "species_10630634", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10640438": { "compartment": "compartment_876", "id": "reaction_10640438", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445" ], "products": [ "species_10640436" ], "modifiers": [ [ "species_10631680", "catalyst" ] ], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10632671": { "compartment": "compartment_17963", "id": "reaction_10632671", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632122" ], "products": [ "species_10632669" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10637180": { "compartment": "compartment_876", "id": "reaction_10637180", "reactome": "R-CEL-2534240", "name": "HSPG2 (perlecan) degradation by MMP14, MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10637177", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631608": { "compartment": "compartment_984", "id": "reaction_10631608", "reactome": "R-CEL-1592314", "name": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631599" ], "products": [ "species_10631601", "species_10631603" ], "modifiers": [ [ "species_10631605", "catalyst" ] ], "additional_components": [ "WBGene00006787", "WBGene00006787", "WBGene00006787", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631690": { "compartment": "compartment_876", "id": "reaction_10631690", "reactome": "R-CEL-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631680", "species_10631686" ], "products": [ "species_10631688" ], "modifiers": [], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q21267", "WBGene00019476", "Q21265", "WBGene00019478", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10631514": { "compartment": "compartment_984", "id": "reaction_10631514", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487" ], "products": [ "species_10631469" ], "modifiers": [ [ "species_10631511", "catalyst" ] ], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "Q9BL26", "WBGene00044760", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "U4PME4", "WBGene00044760" ] }, "reaction_10632294": { "compartment": "compartment_876", "id": "reaction_10632294", "reactome": "R-CEL-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632266" ], "products": [ "species_10632291", "species_10631550" ], "modifiers": [ [ "species_10632266", "catalyst" ] ], "additional_components": [ "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q23227", "WBGene00012364", "O17913", "WBGene00010423", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "Q21267", "WBGene00019476", "Q21182", "WBGene00194737", "Q21265", "WBGene00019478", "O62390", "WBGene00194737", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646" ] }, "reaction_10608300": { "compartment": "compartment_7660", "id": "reaction_10608300", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608291", "species_10608295" ], "products": [ "species_10608297" ], "modifiers": [ [ "species_10608295", "catalyst" ] ], "additional_components": [ "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "G5EC44", "WBGene00003417", "Q95Y97", "WBGene00019767", "Q95Q27", "WBGene00001997", "G5EGG2", "WBGene00001998", "G5EFI9", "WBGene00002042", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "G5EGG2", "WBGene00001998", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10636084": { "compartment": "compartment_12045", "id": "reaction_10636084", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10603812", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10636089": { "compartment": "compartment_12045", "id": "reaction_10636089", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10636086", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620836": { "compartment": "compartment_876", "id": "reaction_10620836", "reactome": "R-CEL-432110", "name": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605504" ], "products": [ "species_10620831" ], "modifiers": [ [ "species_10620833", "catalyst" ] ], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102" ] }, "reaction_10615241": { "compartment": "compartment_984", "id": "reaction_10615241", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_377604", "species_10615215" ], "products": [ "species_10615239" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "species_74016", "species_109496", "species_266099", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615217": { "compartment": "compartment_876", "id": "reaction_10615217", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615193", "species_10615213" ], "products": [ "species_10615215" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856", "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10616380": { "compartment": "compartment_70101", "id": "reaction_10616380", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616372" ], "products": [ "species_10615209", "species_10616378" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856", "WBGene00000812", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10620443": { "compartment": "compartment_70101", "id": "reaction_10620443", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613787", "species_10615195" ], "products": [ "species_10620441" ], "modifiers": [], "additional_components": [ "WBGene00016416", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615181": { "compartment": "compartment_70101", "id": "reaction_10615181", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615177", "species_179856", "species_10615172" ], "products": [ "species_10615179" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10616374": { "compartment": "compartment_876", "id": "reaction_10616374", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615213", "species_10615239" ], "products": [ "species_10616372" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "G5ECJ6", "WBGene00000812", "species_266099", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615259": { "compartment": "compartment_70101", "id": "reaction_10615259", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10615256", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10615232": { "compartment": "compartment_70101", "id": "reaction_10615232", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615179", "species_10615191" ], "products": [ "species_10615193" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_179856", "WBGene00006771", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "species_179856" ] }, "reaction_10620451": { "compartment": "compartment_70101", "id": "reaction_10620451", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620441" ], "products": [ "species_29370", "species_10620448" ], "modifiers": [ [ "species_10620441", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "Q18462", "WBGene00016416", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "Q18462", "WBGene00016416", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10621581": { "compartment": "compartment_876", "id": "reaction_10621581", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621575" ], "products": [ "species_10621579" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856", "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "G5EGK1", "WBGene00006771", "species_29438", "P34400", "WBGene00003243", "G5ECJ6", "WBGene00000812", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "species_179856" ] }, "reaction_10615245": { "compartment": "compartment_70101", "id": "reaction_10615245", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10615228" ], "products": [ "species_10615243" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "Q9N5D3", "WBGene00004947", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615237": { "compartment": "compartment_70101", "id": "reaction_10615237", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615204" ], "products": [ "species_29370", "species_10615226" ], "modifiers": [ [ "species_10615204", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10615230": { "compartment": "compartment_70101", "id": "reaction_10615230", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615226", "species_10602400" ], "products": [ "species_10615228" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "WBGene00004774", "P29355", "WBGene00004774", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10626050": { "compartment": "compartment_70101", "id": "reaction_10626050", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10615247" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617231", "catalyst" ] ], "additional_components": [ "species_29420", "Q18246", "WBGene00004307", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10615207": { "compartment": "compartment_70101", "id": "reaction_10615207", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615197", "species_113592" ], "products": [ "species_29370", "species_10615204" ], "modifiers": [ [ "species_10615197", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10616370": { "compartment": "compartment_70101", "id": "reaction_10616370", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616367" ], "products": [ "species_29370", "species_10615195" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q18246", "WBGene00004307", "species_74016", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "Q27874", "WBGene00003930", "species_109496", "G5EGK1", "WBGene00006771", "species_266099", "P34446", "WBGene00003929", "species_179856", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "WBGene00005077" ] }, "reaction_10615199": { "compartment": "compartment_70101", "id": "reaction_10615199", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10615195" ], "products": [ "species_10615197" ], "modifiers": [], "additional_components": [ "WBGene00002213", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q9XXE9", "WBGene00016769", "G5EGK1", "WBGene00006771", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "species_266099", "Q27874", "WBGene00003930", "species_179856", "P34446", "WBGene00003929", "Q18246", "WBGene00004307", "G5EE56", "WBGene00005077", "species_74016", "Q95YD4", "WBGene00002213", "Q9XXE9", "WBGene00016769", "species_29438", "Q18705", "WBGene00016769", "P34400", "WBGene00003243", "species_109496", "Q27874", "WBGene00003930", "G5EGK1", "WBGene00006771", "species_266099", "species_179856", "P34446", "WBGene00003929" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10599384", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10659512": { "compartment": "compartment_876", "id": "reaction_10659512", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10599379": { "compartment": "compartment_70101", "id": "reaction_10599379", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10599376", "catalyst" ] ], "additional_components": [ "Q09474", "WBGene00016201", "species_71185" ] }, "reaction_10599408": { "compartment": "compartment_70101", "id": "reaction_10599408", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10599405", "catalyst" ] ], "additional_components": [ "species_113531", "Q19341", "WBGene00010595" ] }, "reaction_10625269": { "compartment": "compartment_70101", "id": "reaction_10625269", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10599398": { "compartment": "compartment_70101", "id": "reaction_10599398", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10599395", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10635687": { "compartment": "compartment_17951", "id": "reaction_10635687", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10635685": { "compartment": "compartment_17951", "id": "reaction_10635685", "reactome": "R-CEL-2066781", "name": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_192314", "species_2066765" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10635683": { "compartment": "compartment_17951", "id": "reaction_10635683", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635681": { "compartment": "compartment_17951", "id": "reaction_10635681", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10635600": { "compartment": "compartment_17957", "id": "reaction_10635600", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10635679": { "compartment": "compartment_17951", "id": "reaction_10635679", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10635597": { "compartment": "compartment_12045", "id": "reaction_10635597", "reactome": "R-CEL-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10635602": { "compartment": "compartment_17957", "id": "reaction_10635602", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10660616": { "compartment": "compartment_70101", "id": "reaction_10660616", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660614" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660604": { "compartment": "compartment_70101", "id": "reaction_10660604", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660596" ], "products": [ "species_10660602" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "P34707", "WBGene00004804" ] }, "reaction_10666119": { "compartment": "compartment_70101", "id": "reaction_10666119", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10660612" ], "products": [ "species_10666117" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "P34707", "WBGene00004804", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34707", "WBGene00004804", "LigandDisplayForward?ligandId=7045", "Q17391", "WBGene00000838", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "Q23457", "WBGene00004320" ] }, "reaction_10644873": { "compartment": "compartment_876", "id": "reaction_10644873", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644870" ], "products": [ "species_29370", "species_10644868" ], "modifiers": [ [ "species_10644870", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10626976": { "compartment": "compartment_20699", "id": "reaction_10626976", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_975819", "species_964752" ], "modifiers": [ [ "species_10626973", "catalyst" ] ], "additional_components": [ "species_216667", "Q2PJ74", "WBGene00010284" ] }, "reaction_10649008": { "compartment": "compartment_161320", "id": "reaction_10649008", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10649005", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10626984": { "compartment": "compartment_20699", "id": "reaction_10626984", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975819", "species_914003" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10626981", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10649043": { "compartment": "compartment_17963", "id": "reaction_10649043", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10628551": { "compartment": "compartment_20699", "id": "reaction_10628551", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10628548", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604705", "species_10604589" ], "products": [ "species_10604583", "species_10604707" ], "modifiers": [], "additional_components": [ "WBGene00001372", "Q9U221", "WBGene00013241", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10604711": { "compartment": "compartment_7660", "id": "reaction_10604711", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604605", "species_10604705" ], "products": [ "species_10604707", "species_10604576" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10626216": { "compartment": "compartment_20699", "id": "reaction_10626216", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626190": { "compartment": "compartment_20699", "id": "reaction_10626190", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10626214": { "compartment": "compartment_20699", "id": "reaction_10626214", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10626187", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10661498": { "compartment": "compartment_70101", "id": "reaction_10661498", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627710" ], "products": [ "species_29370", "species_10661496" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10620826": { "compartment": "compartment_876", "id": "reaction_10620826", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10620823", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10620807": { "compartment": "compartment_876", "id": "reaction_10620807", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10620804", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10664833": { "compartment": "compartment_12045", "id": "reaction_10664833", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664831" ], "products": [ "species_10620890" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10626899": { "compartment": "compartment_876", "id": "reaction_10626899", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626896", "catalyst" ] ], "additional_components": [ "G5ECH3", "WBGene00000233", "Q95QT7", "WBGene00001594", "O17274", "WBGene00020836", "Q9N517", "WBGene00021437", "Q17328", "WBGene00001592", "O17402", "WBGene00017314", "A0A1N7SYW0", "WBGene00021146", "Q7YTP9", "WBGene00008076", "Q22741", "WBGene00020767", "Q09453", "WBGene00001586", "G5EBR3", "WBGene00001591", "Q95Q97", "WBGene00000232", "species_159549", "A0A4V0IN81", "WBGene00001587", "G5EEZ3", "WBGene00001593", "A0A4V0IK40", "WBGene00008022", "P90876", "WBGene00009790" ] }, "reaction_10619119": { "compartment": "compartment_876", "id": "reaction_10619119", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618195", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664726": { "compartment": "compartment_12045", "id": "reaction_10664726", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664722", "species_10664720" ], "products": [ "species_10664724" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10628530": { "compartment": "compartment_876", "id": "reaction_10628530", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628525", "species_10628428" ], "products": [ "species_10628527" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10665455": { "compartment": "compartment_876", "id": "reaction_10665455", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10665452", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10665459": { "compartment": "compartment_876", "id": "reaction_10665459", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665457", "species_114523" ], "products": [ "species_10665452" ], "modifiers": [], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10620923": { "compartment": "compartment_984", "id": "reaction_10620923", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10620920", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "species_376186", "O62305", "WBGene00006779", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "G5ECY0", "WBGene00001006" ] }, "reaction_10628532": { "compartment": "compartment_876", "id": "reaction_10628532", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616836", "species_10605064" ], "products": [ "species_10628428" ], "modifiers": [ [ "species_10616836", "catalyst" ] ], "additional_components": [ "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626927", "catalyst" ] ], "additional_components": [ "Q17511", "WBGene00007191", "species_352003", "O18276", "WBGene00001512" ] }, "reaction_10626740": { "compartment": "compartment_876", "id": "reaction_10626740", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10626737", "catalyst" ] ], "additional_components": [ "Q18812", "WBGene00008280", "P41849", "WBGene00020605", "Q9U2E2", "WBGene00012915", "Q9GQ00", "WBGene00003386", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "Q17511", "WBGene00007191", "O18276", "WBGene00001512", "Q6BET0", "WBGene00008551", "G5EEC1", "WBGene00013746", "G5ECN1", "WBGene00013914", "A0A3P6NNS2", "WBGene00017389", "O17041", "WBGene00020528", "Q95Y52", "WBGene00022106", "Q10052", "WBGene00001588", "species_352003", "Q9NA62", "WBGene00013517", "X5LVB0", "WBGene00017399", "Q9U358", "WBGene00012099", "Q21420", "WBGene00010741", "P91985", "WBGene00008223", "G5EEX8", "WBGene00009799", "G5EDN0", "WBGene00018880", "Q21005", "WBGene00010275", "H2KYN9", "WBGene00020657" ] }, "reaction_10628535": { "compartment": "compartment_70101", "id": "reaction_10628535", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10628527", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "A0A1C3NSN6", "WBGene00002150", "G5ECT6", "WBGene00001682", "H2L0Q3", "WBGene00021528", "species_352003", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675" ] }, "reaction_10621327": { "compartment": "compartment_876", "id": "reaction_10621327", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ], [ "species_10621325", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_376186", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_113552", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "P04630", "WBGene00000285", "G5EGQ9", "WBGene00003774", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_159549", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5ECY0", "WBGene00001006", "G5EDZ8", "WBGene00000288" ] }, "reaction_10624678": { "compartment": "compartment_70101", "id": "reaction_10624678", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624675", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10624481": { "compartment": "compartment_876", "id": "reaction_10624481", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10624478", "catalyst" ] ], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10624680": { "compartment": "compartment_984", "id": "reaction_10624680", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624673", "species_372533" ], "products": [ "species_10624675" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997", "Q9N4M3", "WBGene00000045", "B3WFZ2", "WBGene00000058", "P54245", "WBGene00017580", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "Q19351", "WBGene00017375", "P54246", "WBGene00000044", "Q9N4R6", "WBGene00021981", "H2KZY7", "WBGene00022283", "Q23355", "WBGene00000047", "P91197", "WBGene00000050", "Q9U298", "WBGene00001133", "O61519", "WBGene00017544", "Q9XTY8", "WBGene00010994", "Q6F6K3", "WBGene00000056", "Q21645", "WBGene00000049", "Q17999", "WBGene00007594", "B1Q281", "WBGene00000059", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93329", "WBGene00002975", "G5EG88", "WBGene00000062", "P45963", "WBGene00000046", "O16926", "WBGene00000054", "O61520", "WBGene00017543", "G5EG72", "WBGene00000057", "Q6BEQ0", "WBGene00013338", "Q65XS8", "WBGene00043066", "Q22224", "WBGene00000053", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "Q95Y94", "WBGene00020048", "species_264643", "Q93323", "WBGene00007903", "P48182", "WBGene00000042", "P34271", "WBGene00000845", "P48180", "WBGene00000055", "Q23022", "WBGene00006774", "Q22081", "WBGene00011356", "Q93149", "WBGene00000043", "A0A3P6P985", "WBGene00000060", "O44452", "WBGene00015412", "O61216", "WBGene00019069", "Q9NAM5", "WBGene00013655", "Q4W520", "WBGene00044301", "G5ECT0", "WBGene00012857", "Q18556", "WBGene00000048", "O16426", "WBGene00020236", "P48181", "WBGene00006765", "V6CJ96", "WBGene00022247", "Q22085", "WBGene00011359", "Q22084", "WBGene00011360", "Q22083", "WBGene00011358", "Q22080", "WBGene00011355", "Q9N587", "WBGene00006797", "Q22079", "WBGene00011354", "O18228", "WBGene00013300", "G5EE87", "WBGene00008997" ] }, "reaction_10664976": { "compartment": "compartment_70101", "id": "reaction_10664976", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664969", "species_113592" ], "products": [ "species_29370", "species_10664973" ], "modifiers": [ [ "species_10664969", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "Q3Y416", "WBGene00000518", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q3Y416", "WBGene00000518" ] }, "reaction_10619115": { "compartment": "compartment_984", "id": "reaction_10619115", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618182" ], "products": [ "species_10618184" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10618187": { "compartment": "compartment_876", "id": "reaction_10618187", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10618184", "catalyst" ] ], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10624682": { "compartment": "compartment_984", "id": "reaction_10624682", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624476", "species_372533" ], "products": [ "species_10624478" ], "modifiers": [], "additional_components": [ "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043", "Q9N4M3", "WBGene00000045", "Q9XTY8", "WBGene00010994", "G5EDF1", "WBGene00000051", "P54244", "WBGene00000951", "O76554", "WBGene00000955", "A5JYS3", "WBGene00045385", "P54246", "WBGene00000044", "B1Q281", "WBGene00000059", "P48181", "WBGene00006765", "species_264643", "H2KML8", "WBGene00013534", "Q27218", "WBGene00002974", "Q93323", "WBGene00007903", "Q93329", "WBGene00002975", "Q9N4R6", "WBGene00021981", "P48182", "WBGene00000042", "H2KZY7", "WBGene00022283", "P34271", "WBGene00000845", "G5EG88", "WBGene00000062", "Q23355", "WBGene00000047", "Q23022", "WBGene00006774", "Q9N587", "WBGene00006797", "Q93149", "WBGene00000043" ] }, "reaction_10619117": { "compartment": "compartment_984", "id": "reaction_10619117", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10618193" ], "products": [ "species_10618195" ], "modifiers": [], "additional_components": [ "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "species_113552", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615" ] }, "reaction_10664985": { "compartment": "compartment_70101", "id": "reaction_10664985", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10664981" ], "products": [ "species_10664983" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00000553", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10626307": { "compartment": "compartment_876", "id": "reaction_10626307", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113", "species_74126" ], "products": [ "species_29804", "species_74016", "species_83910" ], "modifiers": [ [ "species_10626304", "catalyst" ] ], "additional_components": [ "O61216", "WBGene00019069", "P54245", "WBGene00017580", "G5EE87", "WBGene00008997", "A0A3P6P985", "WBGene00000060", "species_114523" ] }, "reaction_10618079": { "compartment": "compartment_876", "id": "reaction_10618079", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608448", "species_10615689" ], "products": [ "species_10618077" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942" ] }, "reaction_10621804": { "compartment": "compartment_70101", "id": "reaction_10621804", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081", "species_113592", "species_10604515" ], "products": [ "species_29370", "species_10621801" ], "modifiers": [ [ "species_10604515", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401", "Q21465", "WBGene00019727", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P39745", "WBGene00003401", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10624055": { "compartment": "compartment_876", "id": "reaction_10624055", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608453", "species_10618077" ], "products": [ "species_10618081", "species_29372", "species_29420" ], "modifiers": [ [ "species_10609937", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10621565": { "compartment": "compartment_876", "id": "reaction_10621565", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621561", "species_10615689" ], "products": [ "species_10621563" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "Q21773", "WBGene00000963", "Q9XTY6", "WBGene00003830", "Q01630", "WBGene00006769", "Q5WRR1", "WBGene00006942", "Q18677", "WBGene00000964" ] }, "reaction_10615724": { "compartment": "compartment_876", "id": "reaction_10615724", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615720", "species_10615689" ], "products": [ "species_10615722" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856" ] }, "reaction_10621806": { "compartment": "compartment_70101", "id": "reaction_10621806", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615689" ], "products": [ "species_29370", "species_10615718" ], "modifiers": [ [ "species_10610070", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00005077" ] }, "reaction_10621554": { "compartment": "compartment_70101", "id": "reaction_10621554", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10615722" ], "products": [ "species_10621552" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "Q5WRR1", "WBGene00006942", "species_179856", "Q21465", "WBGene00019727", "G5EBK3", "WBGene00001333", "species_113592", "Q5WRR1", "WBGene00006942", "species_179856", "P10984", "WBGene00000064" ] }, "reaction_10618083": { "compartment": "compartment_17940", "id": "reaction_10618083", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618081" ], "products": [ "species_10618081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791", "P34574", "WBGene00011867", "Q21465", "WBGene00019727", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q5WRR1", "WBGene00006942", "B1V8A0", "WBGene00006791" ] }, "reaction_10638811": { "compartment": "compartment_7660", "id": "reaction_10638811", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638788", "species_10638181" ], "products": [ "species_10638809", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10658568": { "compartment": "compartment_7660", "id": "reaction_10658568", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658564" ], "products": [ "species_10658566" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658586": { "compartment": "compartment_70101", "id": "reaction_10658586", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629353", "species_10658582" ], "products": [ "species_10658584" ], "modifiers": [], "additional_components": [ "WBGene00017131", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658588": { "compartment": "compartment_70101", "id": "reaction_10658588", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658582" ], "products": [ "species_10638786" ], "modifiers": [ [ "species_10658584", "inhibitor" ] ], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q95QN9", "WBGene00017131", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10658600": { "compartment": "compartment_7660", "id": "reaction_10658600", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658596", "species_10658594" ], "products": [ "species_10658598" ], "modifiers": [], "additional_components": [ "Q19862", "WBGene00009203", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424", "WBGene00001585", "Q19862", "WBGene00009203", "Q21501", "WBGene00001585", "G2HK15", "WBGene00013383", "Q19863", "WBGene00009202", "Q09585", "WBGene00019424" ] }, "reaction_10622688": { "compartment": "compartment_70101", "id": "reaction_10622688", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_450386" ], "products": [ "species_10622643" ], "modifiers": [], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10622708": { "compartment": "compartment_70101", "id": "reaction_10622708", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622694", "species_10622682" ], "products": [ "species_10622706" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "Q9BLA0", "WBGene00016489", "P41932", "WBGene00003920", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534" ] }, "reaction_10604062": { "compartment": "compartment_7660", "id": "reaction_10604062", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600734", "species_10600755", "species_10600767", "species_10604056", "species_10600739" ], "products": [ "species_10604060" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "WBGene00003904", "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10620715": { "compartment": "compartment_70101", "id": "reaction_10620715", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10620712", "catalyst" ] ], "additional_components": [ "A5Z2V7", "WBGene00008533", "G5EG59", "WBGene00000798", "Q9BKR2", "WBGene00021613", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "P90922", "WBGene00010622", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q19103", "WBGene00008502", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10649092": { "compartment": "compartment_70101", "id": "reaction_10649092", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_430042", "species_29356" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10649089", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10622619": { "compartment": "compartment_70101", "id": "reaction_10622619", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622615", "species_10606995" ], "products": [ "species_10622617" ], "modifiers": [], "additional_components": [ "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10620627": { "compartment": "compartment_70101", "id": "reaction_10620627", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620593", "species_29356" ], "products": [ "species_10620595", "species_430004" ], "modifiers": [ [ "species_10620624", "catalyst" ] ], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479", "Q8ITV6", "WBGene00021551", "O62255", "WBGene00003582", "Q21740", "WBGene00011036" ] }, "reaction_10604054": { "compartment": "compartment_7660", "id": "reaction_10604054", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604050", "species_10600698" ], "products": [ "species_10604052" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17403", "WBGene00017313", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797" ] }, "reaction_10622686": { "compartment": "compartment_70101", "id": "reaction_10622686", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622645", "species_450523" ], "products": [ "species_10622647" ], "modifiers": [], "additional_components": [ "WBGene00009532", "Q20155", "WBGene00009532" ] }, "reaction_10604044": { "compartment": "compartment_7660", "id": "reaction_10604044", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604038" ], "products": [ "species_10604042", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10622668": { "compartment": "compartment_70101", "id": "reaction_10622668", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622615" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10623677": { "compartment": "compartment_70101", "id": "reaction_10623677", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606995", "species_10622653" ], "products": [ "species_10623675" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10604761": { "compartment": "compartment_7660", "id": "reaction_10604761", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604036", "species_10603997" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10610139": { "compartment": "compartment_70101", "id": "reaction_10610139", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610135", "species_10610130" ], "products": [ "species_10610137" ], "modifiers": [], "additional_components": [ "WBGene00017746", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920" ] }, "reaction_10603876": { "compartment": "compartment_7660", "id": "reaction_10603876", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850", "species_10603872", "species_10603866" ], "products": [ "species_10603874" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00005015", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10604070": { "compartment": "compartment_7660", "id": "reaction_10604070", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10600734", "species_10604068", "species_10600767", "species_10600739" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "WBGene00003904" ] }, "reaction_10622665": { "compartment": "compartment_70101", "id": "reaction_10622665", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620691", "species_10620605", "species_10622647", "species_10620612", "species_10622661" ], "products": [ "species_10622663" ], "modifiers": [], "additional_components": [ "Q93830", "WBGene00010325", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "Q95QG7", "WBGene00018305", "G5EDS8", "WBGene00009289", "Q9XXD2", "WBGene00012966", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001", "WBGene00021929", "Q20155", "WBGene00009532", "WBGene00003582", "WBGene00012730", "G5EG59", "WBGene00000798", "Q95XD0", "WBGene00022232", "Q20128", "WBGene00018154", "G5EDS8", "WBGene00009289", "Q9BHK7", "WBGene00012730", "O62255", "WBGene00003582", "Q9XXD2", "WBGene00012966", "Q20155", "WBGene00009532", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "Q17533", "WBGene00007201", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "Q17632", "WBGene00001001" ] }, "reaction_10622656": { "compartment": "compartment_70101", "id": "reaction_10622656", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622647" ], "products": [ "species_29370", "species_10622653" ], "modifiers": [ [ "species_10609568", "catalyst" ] ], "additional_components": [ "Q20155", "WBGene00009532", "Q20155", "WBGene00009532", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10604040": { "compartment": "compartment_7660", "id": "reaction_10604040", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604004", "species_10604036" ], "products": [ "species_10604038" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q09599", "WBGene00000411" ] }, "reaction_10603908": { "compartment": "compartment_7660", "id": "reaction_10603908", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599879", "species_10599884" ], "products": [ "species_10599886" ], "modifiers": [], "additional_components": [ "WBGene00009141", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10604006": { "compartment": "compartment_7660", "id": "reaction_10604006", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604002", "species_10603997" ], "products": [ "species_10604004" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10603901": { "compartment": "compartment_7660", "id": "reaction_10603901", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603894" ], "products": [ "species_10603899" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10620637": { "compartment": "compartment_70101", "id": "reaction_10620637", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620591", "species_429974" ], "products": [ "species_10620593" ], "modifiers": [], "additional_components": [ "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q20374", "WBGene00009661", "Q23543", "WBGene00003081", "P92022", "WBGene00001808", "O18694", "WBGene00003079", "Q20229", "WBGene00003076", "Q19952", "WBGene00003078", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077" ] }, "reaction_10625887": { "compartment": "compartment_70101", "id": "reaction_10625887", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625883", "species_10625863" ], "products": [ "species_10625885" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00004880", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "Q9U302", "WBGene00003902", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "Q93594", "WBGene00009141", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "O45622", "WBGene00010405", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "O76512", "WBGene00004880", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "D0G912", "WBGene00194816", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "species_29420", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01763", "WBGene00018156", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O16520", "WBGene00020269", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10622684": { "compartment": "compartment_70101", "id": "reaction_10622684", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622641", "species_113592" ], "products": [ "species_29370", "species_10622682" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "P91393", "WBGene00019692", "Q9BLA0", "WBGene00016489", "Q23487", "WBGene00022738", "Q17936", "WBGene00007534", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10603897": { "compartment": "compartment_7660", "id": "reaction_10603897", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603889" ], "products": [ "species_10603894" ], "modifiers": [ [ "species_10603889", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603892": { "compartment": "compartment_7660", "id": "reaction_10603892", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10603882" ], "products": [ "species_111349", "species_10603889" ], "modifiers": [ [ "species_10603882", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "species_113578", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610188": { "compartment": "compartment_13231", "id": "reaction_10610188", "reactome": "R-CEL-191830", "name": "snRNP nuclear import and release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610137" ], "products": [ "species_10610180", "species_10610135", "species_10610186" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "O17066", "WBGene00017746", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "A7LPI7", "WBGene00007702", "WBGene00017746", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "CHEBI:1604", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "Q9N4G9", "WBGene00004920", "Q17348", "WBGene00004914", "Q10013", "WBGene00004916", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10603906": { "compartment": "compartment_7660", "id": "reaction_10603906", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603899", "species_77087" ], "products": [ "species_10599965", "species_10601853", "species_10603872", "species_10603903", "species_77502" ], "modifiers": [ [ "species_10603899", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603856": { "compartment": "compartment_7660", "id": "reaction_10603856", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603848", "species_10603854" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604759": { "compartment": "compartment_7660", "id": "reaction_10604759", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604755" ], "products": [ "species_10604757", "species_10604036" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34659", "WBGene00004918", "P91918", "WBGene00004915", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q17348", "WBGene00004914" ] }, "reaction_10620635": { "compartment": "compartment_70101", "id": "reaction_10620635", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429926", "species_29356" ], "products": [ "species_429925", "species_430042" ], "modifiers": [ [ "species_10620632", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10603852": { "compartment": "compartment_7660", "id": "reaction_10603852", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603850" ], "products": [ "species_10603850" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q17607", "WBGene00000466", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10604066": { "compartment": "compartment_7660", "id": "reaction_10604066", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604060" ], "products": [ "species_10600717", "species_10600755", "species_10604064", "species_112165", "species_10600767" ], "modifiers": [], "additional_components": [ "O17403", "WBGene00017313", "Q93716", "WBGene00009668", "Q9U2P3", "WBGene00012528", "Q9N4C2", "WBGene00022301", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "G5EBX5", "WBGene00009658", "C1P629", "WBGene00008362", "Q93594", "WBGene00009141", "Q93233", "WBGene00003904", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q09345", "WBGene00020092", "P52874", "WBGene00010304", "Q95PY8", "WBGene00013460", "Q7YTG9", "WBGene00044329", "O16929", "WBGene00017797", "Q19866", "WBGene00006307", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "C1P629", "WBGene00008362", "Q93716", "WBGene00009668", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "Q93233", "WBGene00003904", "O01763", "WBGene00018156", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "G5EBX5", "WBGene00009658", "Q09345", "WBGene00020092", "P52874", "WBGene00010304" ] }, "reaction_10603910": { "compartment": "compartment_7660", "id": "reaction_10603910", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599965", "species_10599886" ], "products": [ "species_10599967" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10603885": { "compartment": "compartment_7660", "id": "reaction_10603885", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603878" ], "products": [ "species_113550", "species_10603882" ], "modifiers": [ [ "species_10603878", "catalyst" ] ], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10603880": { "compartment": "compartment_7660", "id": "reaction_10603880", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10603874" ], "products": [ "species_10603878" ], "modifiers": [], "additional_components": [ "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q17607", "WBGene00000466", "Q21338", "WBGene00005015", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9XVS1", "WBGene00006447", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296" ] }, "reaction_10610151": { "compartment": "compartment_70101", "id": "reaction_10610151", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610143" ], "products": [ "species_10610130" ], "modifiers": [ [ "species_10610148", "catalyst" ] ], "additional_components": [ "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:2274", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "O01871", "WBGene00017002", "Q9XTU6", "WBGene00004919", "Q18786", "WBGene00004917", "G5EC16", "WBGene00004887", "G5ED26", "WBGene00020284", "Q10013", "WBGene00004916", "Q17348", "WBGene00004914", "A7LPI7", "WBGene00007702", "CHEBI:1604", "P91918", "WBGene00004915", "P34659", "WBGene00004918", "Q9N405", "WBGene00004886", "P34399", "WBGene00017357", "Q9N4G9", "WBGene00004920", "WBGene00011631" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600717", "species_10604052" ], "products": [ "species_10604056" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O17403", "WBGene00017313", "O45577", "WBGene00000774", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "Q19864", "WBGene00000773", "U4PCM1", "WBGene00011051", "O16929", "WBGene00017797", "Q19866", "WBGene00006307" ] }, "reaction_10659874": { "compartment": "compartment_70101", "id": "reaction_10659874", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659871", "species_113592" ], "products": [ "species_29370", "species_10659858" ], "modifiers": [ [ "species_10659871", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10659867": { "compartment": "compartment_70101", "id": "reaction_10659867", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659858", "species_113592" ], "products": [ "species_29370", "species_10659864" ], "modifiers": [ [ "species_10659858", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10641084": { "compartment": "compartment_7660", "id": "reaction_10641084", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10641071" ], "products": [ "species_113582", "species_10641081" ], "modifiers": [ [ "species_10641067", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10641029": { "compartment": "compartment_70101", "id": "reaction_10641029", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641021" ], "products": [ "species_29370", "species_10641016" ], "modifiers": [ [ "species_10641021", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10637600": { "compartment": "compartment_70101", "id": "reaction_10637600", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635196", "species_74016", "species_10604898" ], "products": [ "species_10637574" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "species_912516", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641019": { "compartment": "compartment_70101", "id": "reaction_10641019", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641016" ], "products": [ "species_29370", "species_10641014", "species_10604898" ], "modifiers": [ [ "species_10641016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "O62305", "WBGene00006779", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641025": { "compartment": "compartment_70101", "id": "reaction_10641025", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620916", "species_10604898" ], "products": [ "species_10641021" ], "modifiers": [ [ "species_10641023", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10641069": { "compartment": "compartment_7660", "id": "reaction_10641069", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641063" ], "products": [ "species_10641067" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10640879": { "compartment": "compartment_876", "id": "reaction_10640879", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640874" ], "products": [ "species_10640857", "species_10605064", "species_10640864" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9BIG5", "WBGene00001666", "P51875", "WBGene00001648", "Q9N2V6", "WBGene00001678" ] }, "reaction_10640877": { "compartment": "compartment_876", "id": "reaction_10640877", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640870", "species_29438" ], "products": [ "species_10640874", "species_29420" ], "modifiers": [ [ "species_10640870", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "G5ECT6", "WBGene00001682", "Q9N2V6", "WBGene00001678", "species_29420", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "P51875", "WBGene00001648", "A0A0K3AWM6", "T23D8.1b", "Q20636", "WBGene00001680", "Q27886", "WBGene00003029", "Q9N532", "WBGene00003238", "P54406", "WBGene00001681" ] }, "reaction_10641175": { "compartment": "compartment_70101", "id": "reaction_10641175", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641169" ], "products": [ "species_10641173" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10603920": { "compartment": "compartment_5460", "id": "reaction_10603920", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77252", "species_113526" ], "products": [ "species_77253", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603922": { "compartment": "compartment_5460", "id": "reaction_10603922", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603961": { "compartment": "compartment_5460", "id": "reaction_10603961", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10613700": { "compartment": "compartment_70101", "id": "reaction_10613700", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10613697", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10662871": { "compartment": "compartment_161320", "id": "reaction_10662871", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662869" ], "products": [ "species_10662867", "species_350136" ], "modifiers": [], "additional_components": [ "species_350136", "Q93212", "WBGene00004944", "WBGene00004944" ] }, "reaction_10662875": { "compartment": "compartment_7660", "id": "reaction_10662875", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8963912", "species_10616155" ], "products": [ "species_10662873" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "species_8963912" ] }, "reaction_10629238": { "compartment": "compartment_876", "id": "reaction_10629238", "reactome": "R-CEL-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10629233" ], "products": [ "species_29370", "species_10629235" ], "modifiers": [ [ "species_10629233", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643411": { "compartment": "compartment_7660", "id": "reaction_10643411", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10636603": { "compartment": "compartment_984", "id": "reaction_10636603", "reactome": "R-CEL-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636599", "species_10631599" ], "products": [ "species_10636601" ], "modifiers": [], "additional_components": [ "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881", "WBGene00006787", "Q21882", "WBGene00022808", "Q9N413", "WBGene00004249", "Q06561", "WBGene00006787", "O44578", "WBGene00022808", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q11184", "WBGene00002881" ] }, "reaction_10614244": { "compartment": "compartment_12045", "id": "reaction_10614244", "reactome": "R-CEL-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614257": { "compartment": "compartment_17960", "id": "reaction_10614257", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10614254", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603732": { "compartment": "compartment_12045", "id": "reaction_10603732", "reactome": "R-CEL-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10603729", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614249": { "compartment": "compartment_17960", "id": "reaction_10614249", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10650224": { "compartment": "compartment_12045", "id": "reaction_10650224", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6786220", "species_29368" ], "products": [ "species_29366", "species_29356", "species_6786225" ], "modifiers": [ [ "species_10650221", "catalyst" ] ], "additional_components": [ "WBGene00011830" ] }, "reaction_10614237": { "compartment": "compartment_12045", "id": "reaction_10614237", "reactome": "R-CEL-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10614234", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614264": { "compartment": "compartment_12045", "id": "reaction_10614264", "reactome": "R-CEL-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614262": { "compartment": "compartment_17960", "id": "reaction_10614262", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10614259", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10610411": { "compartment": "compartment_70101", "id": "reaction_10610411", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193079" ], "products": [ "species_29366", "species_29460", "species_193066", "species_29356" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10603727": { "compartment": "compartment_17960", "id": "reaction_10603727", "reactome": "R-CEL-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603819": { "compartment": "compartment_17960", "id": "reaction_10603819", "reactome": "R-CEL-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614232": { "compartment": "compartment_17960", "id": "reaction_10614232", "reactome": "R-CEL-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10603636", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603721": { "compartment": "compartment_17960", "id": "reaction_10603721", "reactome": "R-CEL-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10605850": { "compartment": "compartment_17957", "id": "reaction_10605850", "reactome": "R-CEL-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603725": { "compartment": "compartment_17960", "id": "reaction_10603725", "reactome": "R-CEL-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614269": { "compartment": "compartment_12045", "id": "reaction_10614269", "reactome": "R-CEL-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603723": { "compartment": "compartment_17957", "id": "reaction_10603723", "reactome": "R-CEL-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10603718", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614252": { "compartment": "compartment_12045", "id": "reaction_10614252", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614242": { "compartment": "compartment_12045", "id": "reaction_10614242", "reactome": "R-CEL-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10614239", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614276": { "compartment": "compartment_12045", "id": "reaction_10614276", "reactome": "R-CEL-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614266", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10614274": { "compartment": "compartment_12045", "id": "reaction_10614274", "reactome": "R-CEL-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10614271", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10603817": { "compartment": "compartment_12045", "id": "reaction_10603817", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10603814", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10637598": { "compartment": "compartment_70101", "id": "reaction_10637598", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637578" ], "products": [ "species_10637596" ], "modifiers": [], "additional_components": [ "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "Q0G819", "WBGene00006527", "species_216667", "G5EDN6", "WBGene00000554", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_912516", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10638009": { "compartment": "compartment_70101", "id": "reaction_10638009", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473610" ], "products": [ "species_10636648" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10626966": { "compartment": "compartment_70101", "id": "reaction_10626966", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10626963", "catalyst" ] ], "additional_components": [ "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10602452": { "compartment": "compartment_70101", "id": "reaction_10602452", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473604" ], "products": [ "species_10602450" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637084": { "compartment": "compartment_70101", "id": "reaction_10637084", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_74016", "species_83910" ], "modifiers": [ [ "species_10602105", "catalyst" ] ], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10636806": { "compartment": "compartment_70101", "id": "reaction_10636806", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10636803", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10637063": { "compartment": "compartment_2514888", "id": "reaction_10637063", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637061" ], "products": [ "species_10637052", "species_10637059" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "Q9BIG5", "WBGene00001666", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10602107": { "compartment": "compartment_70101", "id": "reaction_10602107", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10602103" ], "products": [ "species_10602105" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295" ] }, "reaction_10637131": { "compartment": "compartment_2514888", "id": "reaction_10637131", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637121", "species_2530486" ], "products": [ "species_10637057", "species_111294" ], "modifiers": [ [ "species_10637128", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10626938": { "compartment": "compartment_984", "id": "reaction_10626938", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975591", "species_109276" ], "products": [ "species_426576", "species_975590" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10637150": { "compartment": "compartment_70101", "id": "reaction_10637150", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637140", "species_2534019" ], "products": [ "species_10637048", "species_76194" ], "modifiers": [ [ "species_10637145", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "WBGene00020549" ] }, "reaction_10642008": { "compartment": "compartment_5460", "id": "reaction_10642008", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10642005", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "species_113531", "Q9U2E4", "WBGene00012914" ] }, "reaction_10637081": { "compartment": "compartment_70101", "id": "reaction_10637081", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602105" ], "products": [ "species_30991", "species_10602103" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "species_30991", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10638007": { "compartment": "compartment_70101", "id": "reaction_10638007", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10626954" ], "products": [ "species_29366", "species_10626952" ], "modifiers": [ [ "species_10638004", "catalyst" ] ], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10637175": { "compartment": "compartment_70101", "id": "reaction_10637175", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637156" ], "products": [ "species_10637140", "species_174390" ], "modifiers": [ [ "species_10637172", "catalyst" ] ], "additional_components": [ "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "Q965Y1", "WBGene00003129", "species_880069", "H1UBK1", "WBGene00003130" ] }, "reaction_10636780": { "compartment": "compartment_70101", "id": "reaction_10636780", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_70106", "species_2864103", "species_30927" ], "modifiers": [ [ "species_10636772", "catalyst" ], [ "species_10636778", "catalyst" ] ], "additional_components": [ "species_2534407", "CHEBI:70761", "CHEBI:70760", "CHEBI:70762", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "Q9TXT9", "WBGene00018755", "H2L060", "WBGene00018640", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10636650": { "compartment": "compartment_70101", "id": "reaction_10636650", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636648" ], "products": [ "species_10602448", "species_2473616" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10638750": { "compartment": "compartment_70101", "id": "reaction_10638750", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10602103" ], "products": [ "species_10638748" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q94288", "WBGene00000287", "A8WI01", "WBGene00000562", "Q18136", "WBGene00006861", "species_74016", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q7Z205", "WBGene00000563", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "O02159", "WBGene00020378", "Q9N4C1", "WBGene00022295", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10636642": { "compartment": "compartment_984", "id": "reaction_10636642", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636634", "species_2395761" ], "products": [ "species_10636636" ], "modifiers": [], "additional_components": [ "WBGene00011726", "G5EEB8", "WBGene00011726", "species_5623649" ] }, "reaction_10636646": { "compartment": "compartment_70101", "id": "reaction_10636646", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_2473616" ], "products": [ "species_10636644" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10637319": { "compartment": "compartment_70101", "id": "reaction_10637319", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10637309" ], "products": [ "species_10637317" ], "modifiers": [], "additional_components": [ "P36609", "WBGene00003564", "O02217", "WBGene00007710", "P36609", "WBGene00003564", "species_74016", "O02217", "WBGene00007710" ] }, "reaction_10636629": { "compartment": "compartment_70101", "id": "reaction_10636629", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10626950" ], "products": [ "species_10626954" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623648" ] }, "reaction_10626956": { "compartment": "compartment_70101", "id": "reaction_10626956", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626950", "species_975590" ], "products": [ "species_10626952" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "species_5623649" ] }, "reaction_10636640": { "compartment": "compartment_984", "id": "reaction_10636640", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636636", "species_10636597" ], "products": [ "species_10636638" ], "modifiers": [], "additional_components": [ "G5EEB8", "WBGene00011726", "species_5623649", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "G5EEB8", "WBGene00011726", "species_5623649", "O44578", "WBGene00022808" ] }, "reaction_10636485": { "compartment": "compartment_7660", "id": "reaction_10636485", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636483", "species_10605870" ], "products": [ "species_10636465" ], "modifiers": [], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00004043", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636457": { "compartment": "compartment_7660", "id": "reaction_10636457", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10636183" ], "products": [ "species_10636455" ], "modifiers": [ [ "species_10636174", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636453": { "compartment": "compartment_7660", "id": "reaction_10636453", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636196" ], "products": [ "species_113582", "species_10636183", "species_10636451" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "species_113531", "Q9GYI0", "WBGene00017920", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636176": { "compartment": "compartment_7660", "id": "reaction_10636176", "reactome": "R-CEL-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636172", "species_10598308" ], "products": [ "species_10636174" ], "modifiers": [], "additional_components": [ "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "WBGene00003020", "Q20060", "WBGene00004874", "G5EDT1", "WBGene00003020", "Q20818", "WBGene00010093", "Q95Y84", "WBGene00001833", "Q09591", "WBGene00003367", "P34341", "WBGene00016202" ] }, "reaction_10636495": { "compartment": "compartment_7660", "id": "reaction_10636495", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636200", "species_77087" ], "products": [ "species_10636196", "species_77502" ], "modifiers": [ [ "species_10636492", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "WBGene00004781" ] }, "reaction_10636435": { "compartment": "compartment_20699", "id": "reaction_10636435", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636427", "species_113592" ], "products": [ "species_29370", "species_10636432" ], "modifiers": [ [ "species_10636427", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "Q9N3Y1", "WBGene00021536", "species_29438", "Q19989", "WBGene00018017" ] }, "reaction_10636487": { "compartment": "compartment_7660", "id": "reaction_10636487", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636455" ], "products": [ "species_113582", "species_10636483" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q20060", "WBGene00004874", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10636696": { "compartment": "compartment_20699", "id": "reaction_10636696", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636677" ], "products": [ "species_29370", "species_10636683" ], "modifiers": [ [ "species_10636693", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "Q9N3Y1", "WBGene00021536", "species_29438", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10636481": { "compartment": "compartment_7660", "id": "reaction_10636481", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10636465" ], "products": [ "species_113582", "species_10636478" ], "modifiers": [ [ "species_10636465", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q09591", "WBGene00003367", "P04255", "WBGene00001885", "P34341", "WBGene00016202", "P09588", "WBGene00001877", "Q9N2L7", "WBGene00004043", "Q20060", "WBGene00004874", "Q27876", "WBGene00001922", "Q20818", "WBGene00010093", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q95Y84", "WBGene00001833", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10636203": { "compartment": "compartment_7660", "id": "reaction_10636203", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10636196", "species_113685" ], "products": [ "species_10636200", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10636196", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "species_113531", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9GYI0", "WBGene00017920" ] }, "reaction_10611278": { "compartment": "compartment_7660", "id": "reaction_10611278", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611266" ], "products": [ "species_113582", "species_10611276" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611288": { "compartment": "compartment_7660", "id": "reaction_10611288", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611283" ], "products": [ "species_113582", "species_10611286" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611197": { "compartment": "compartment_7660", "id": "reaction_10611197", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10611166": { "compartment": "compartment_7660", "id": "reaction_10611166", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611144" ], "products": [ "species_113582", "species_10611147" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10664163": { "compartment": "compartment_70101", "id": "reaction_10664163", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664166": { "compartment": "compartment_70101", "id": "reaction_10664166", "reactome": "R-CEL-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10664168": { "compartment": "compartment_70101", "id": "reaction_10664168", "reactome": "R-CEL-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620391": { "compartment": "compartment_70101", "id": "reaction_10620391", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10604843", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10618931": { "compartment": "compartment_70101", "id": "reaction_10618931", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610070" ], "products": [ "species_10615234" ], "modifiers": [], "additional_components": [ "WBGene00005077", "WBGene00005077" ] }, "reaction_10648796": { "compartment": "compartment_70101", "id": "reaction_10648796", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607380" ], "products": [ "species_10607378" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "WBGene00004467" ] }, "reaction_10648793": { "compartment": "compartment_7660", "id": "reaction_10648793", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648788" ], "products": [ "species_10648790", "species_10597874" ], "modifiers": [ [ "species_10648788", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10607397": { "compartment": "compartment_5460", "id": "reaction_10607397", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607392", "species_31649" ], "products": [ "species_113596", "species_10607394" ], "modifiers": [ [ "species_10607392", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187" ] }, "reaction_10607405": { "compartment": "compartment_5460", "id": "reaction_10607405", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607394", "species_73663" ], "products": [ "species_76633", "species_10607392" ], "modifiers": [ [ "species_10607402", "catalyst" ] ], "additional_components": [ "species_76577", "Q9TXI4", "WBGene00017734", "species_31649", "Q93615", "WBGene00009187", "species_76577", "Q9TXI4", "WBGene00017734", "species_113596", "Q93615", "WBGene00009187", "WBGene00002855" ] }, "reaction_10654352": { "compartment": "compartment_70616", "id": "reaction_10654352", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654304", "species_10654348" ], "products": [ "species_10654350" ], "modifiers": [], "additional_components": [ "Q9BL33", "WBGene00022169", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "O18236", "WBGene00013308", "Q23098", "WBGene00012166", "species_113596", "P90789", "WBGene00008414", "O02267", "WBGene00009740", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596", "Q9N3H3", "WBGene00021800", "Q93931", "WBGene00011123", "O18236", "WBGene00013308", "P90789", "WBGene00008414", "Q18359", "WBGene00007880", "H2KYV1", "WBGene00016118", "Q22619", "WBGene00020636", "Q9XWG2", "WBGene00013406", "Q18036", "WBGene00015810", "Q94360", "WBGene00012376", "Q9BL33", "WBGene00022169", "I2HAE1", "WBGene00021421", "O44509", "WBGene00018361", "Q9U241", "WBGene00013237", "Q93873", "WBGene00001520", "O44955", "WBGene00016393", "Q93831", "WBGene00010326", "Q86NC2", "WBGene00020417", "Q17439", "WBGene00007113", "Q23098", "WBGene00012166", "species_113596", "O02267", "WBGene00009740", "Q9BL03", "WBGene00021849", "Q9XWJ5", "WBGene00013094", "Q18095", "WBGene00007684", "Q21233", "WBGene00019401", "Q20412", "WBGene00009712", "Q09644", "WBGene00014227" ] }, "reaction_10654384": { "compartment": "compartment_5460", "id": "reaction_10654384", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654336", "species_10654346", "species_10654331", "species_10654341" ], "products": [ "species_10654348" ], "modifiers": [], "additional_components": [ "WBGene00011123", "WBGene00021421", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596", "WBGene00007113", "Q9N3H3", "WBGene00021800", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q17439", "WBGene00007113", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10655491": { "compartment": "compartment_5460", "id": "reaction_10655491", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654329", "species_10654320", "species_10654324", "species_10654322", "species_10654313" ], "products": [ "species_10654331" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q9N3H3", "WBGene00021800", "species_113596", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q9N3H3", "WBGene00021800", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q86NC2", "WBGene00020417", "Q09644", "WBGene00014227", "Q94360", "WBGene00012376", "species_113596" ] }, "reaction_10635778": { "compartment": "compartment_70101", "id": "reaction_10635778", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635776" ], "products": [ "species_10614163" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10614183": { "compartment": "compartment_70101", "id": "reaction_10614183", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614163" ], "products": [ "species_10614181" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10660554": { "compartment": "compartment_5460", "id": "reaction_10660554", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607390", "species_2162265" ], "products": [ "species_2162252", "species_10660546" ], "modifiers": [ [ "species_10660551", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10660627": { "compartment": "compartment_70101", "id": "reaction_10660627", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_71285", "species_10660619" ], "modifiers": [ [ "species_10660624", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10660565": { "compartment": "compartment_70101", "id": "reaction_10660565", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605919" ], "products": [ "species_10660557", "species_71285" ], "modifiers": [ [ "species_10660562", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10660587": { "compartment": "compartment_70101", "id": "reaction_10660587", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10643036" ], "products": [ "species_71285", "species_10660579" ], "modifiers": [ [ "species_10660584", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10620234": { "compartment": "compartment_876", "id": "reaction_10620234", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_10620228" ], "products": [ "species_10620232" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "G5EF96", "unc-40" ] }, "reaction_10661405": { "compartment": "compartment_17957", "id": "reaction_10661405", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634735" ], "products": [ "species_10634737" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10608764": { "compartment": "compartment_70101", "id": "reaction_10608764", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608761" ], "products": [ "species_29370", "species_10608706" ], "modifiers": [ [ "species_10608761", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608753": { "compartment": "compartment_70101", "id": "reaction_10608753", "reactome": "R-CEL-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608746", "species_10597908" ], "products": [ "species_10608750" ], "modifiers": [ [ "species_10608746", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10658941": { "compartment": "compartment_876", "id": "reaction_10658941", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658936", "species_113592" ], "products": [ "species_29370", "species_10658938" ], "modifiers": [ [ "species_10658936", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10658951": { "compartment": "compartment_876", "id": "reaction_10658951", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658938", "species_29356" ], "products": [ "species_10658936", "species_29372" ], "modifiers": [ [ "species_10658948", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O01498", "WBGene00004109", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_179856", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "WBGene00004213" ] }, "reaction_10608704": { "compartment": "compartment_70101", "id": "reaction_10608704", "reactome": "R-CEL-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608631", "species_10597908" ], "products": [ "species_10608701" ], "modifiers": [ [ "species_10608631", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608735": { "compartment": "compartment_70101", "id": "reaction_10608735", "reactome": "R-CEL-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608731", "species_10608708" ], "products": [ "species_10608733" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532" ] }, "reaction_10608775": { "compartment": "compartment_70101", "id": "reaction_10608775", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608770", "species_10597908" ], "products": [ "species_10608772", "species_10608761" ], "modifiers": [ [ "species_10608770", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532", "WBGene00006727", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "P0CG71", "WBGene00006727", "O62422", "WBGene00012532", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10608757": { "compartment": "compartment_70101", "id": "reaction_10608757", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10602400" ], "products": [ "species_10608755" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10608779": { "compartment": "compartment_70101", "id": "reaction_10608779", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608624", "species_10608731" ], "products": [ "species_10608777" ], "modifiers": [], "additional_components": [ "WBGene00004829", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10608742": { "compartment": "compartment_70101", "id": "reaction_10608742", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608706", "species_10597908" ], "products": [ "species_10608739" ], "modifiers": [ [ "species_10608706", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P0CG71", "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608768": { "compartment": "compartment_70101", "id": "reaction_10608768", "reactome": "R-CEL-183072", "name": "EGFR non-clathrin mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608683", "species_10608631", "species_10608658", "species_10608639" ], "products": [ "species_10608685" ], "modifiers": [], "additional_components": [ "WBGene00001224", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10608710": { "compartment": "compartment_70101", "id": "reaction_10608710", "reactome": "R-CEL-182994", "name": "Assembly of EGFR complex in clathrin-coated vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10608706" ], "products": [ "species_10608708" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791" ] }, "reaction_10608634": { "compartment": "compartment_70101", "id": "reaction_10608634", "reactome": "R-CEL-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10608626" ], "products": [ "species_29370", "species_10608631" ], "modifiers": [ [ "species_10608626", "catalyst" ] ], "additional_components": [ "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608766": { "compartment": "compartment_70101", "id": "reaction_10608766", "reactome": "R-CEL-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608755", "species_10608528" ], "products": [ "species_10608761" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608759": { "compartment": "compartment_876", "id": "reaction_10608759", "reactome": "R-CEL-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608624" ], "products": [ "species_10608626" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608699": { "compartment": "compartment_70101", "id": "reaction_10608699", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608685", "species_10597908" ], "products": [ "species_10608696" ], "modifiers": [ [ "species_10608685", "catalyst" ] ], "additional_components": [ "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00006727", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q6A573", "WBGene00021549", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10658943": { "compartment": "compartment_876", "id": "reaction_10658943", "reactome": "R-CEL-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608660", "species_10608708", "species_10608658", "species_179856", "species_10608639" ], "products": [ "species_10658936" ], "modifiers": [], "additional_components": [ "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9BI71", "WBGene00001329", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856" ] }, "reaction_10661673": { "compartment": "compartment_70101", "id": "reaction_10661673", "reactome": "R-CEL-8951490", "name": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608733" ], "products": [ "species_10608683", "species_10608770" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "Q6A573", "WBGene00021549", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "O62422", "WBGene00012532", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "Q19019", "WBGene00004829", "species_29438", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "O62422", "WBGene00012532" ] }, "reaction_10664920": { "compartment": "compartment_984", "id": "reaction_10664920", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10664916" ], "products": [ "species_10664918" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344", "WBGene00000039", "LigandDisplayForward?ligandId=6576", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6360", "pubchem.compound:5488746", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=5158", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q18581", "WBGene00000039", "LigandDisplayForward?ligandId=6378", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6344" ] }, "reaction_10664965": { "compartment": "compartment_984", "id": "reaction_10664965", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10648914", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "A0A1C3NSL8", "WBGene00017478" ] }, "reaction_10641650": { "compartment": "compartment_7660", "id": "reaction_10641650", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641629", "species_10638181" ], "products": [ "species_10641648", "species_10638173" ], "modifiers": [], "additional_components": [ "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XYB7", "WBGene00003607", "CHEBI:16755", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "P55853", "WBGene00004888", "WBGene00006706" ] }, "reaction_10604599": { "compartment": "compartment_7660", "id": "reaction_10604599", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604596" ], "products": [ "species_10604589", "species_110216" ], "modifiers": [ [ "species_10604596", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604615": { "compartment": "compartment_7660", "id": "reaction_10604615", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604612" ], "products": [ "species_10604605", "species_110225" ], "modifiers": [ [ "species_10604612", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604629": { "compartment": "compartment_7660", "id": "reaction_10604629", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604626" ], "products": [ "species_10604605", "species_5637659" ], "modifiers": [ [ "species_10604626", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604592": { "compartment": "compartment_7660", "id": "reaction_10604592", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604585" ], "products": [ "species_29554", "species_10604589" ], "modifiers": [ [ "species_10604585", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10604718": { "compartment": "compartment_7660", "id": "reaction_10604718", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604707" ], "products": [ "species_10604715" ], "modifiers": [ [ "species_10604707", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10646034": { "compartment": "compartment_7660", "id": "reaction_10646034", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715" ], "products": [ "species_10646032" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10604608": { "compartment": "compartment_7660", "id": "reaction_10604608", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604603" ], "products": [ "species_10604605", "species_110223" ], "modifiers": [ [ "species_10604603", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10604622": { "compartment": "compartment_7660", "id": "reaction_10604622", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604619" ], "products": [ "species_30140", "species_10604605" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10603043": { "compartment": "compartment_70101", "id": "reaction_10603043", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10649471": { "compartment": "compartment_12045", "id": "reaction_10649471", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10649468", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10623982": { "compartment": "compartment_70101", "id": "reaction_10623982", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10623979", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10654790": { "compartment": "compartment_12045", "id": "reaction_10654790", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10654787", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10603094": { "compartment": "compartment_70101", "id": "reaction_10603094", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10603087", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10603055": { "compartment": "compartment_70101", "id": "reaction_10603055", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10603052", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10603104": { "compartment": "compartment_70101", "id": "reaction_10603104", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10603101", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10620748": { "compartment": "compartment_70101", "id": "reaction_10620748", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620739", "species_10620744" ], "products": [ "species_10620746" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10622178": { "compartment": "compartment_70101", "id": "reaction_10622178", "reactome": "R-CEL-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622174", "species_10608499" ], "products": [ "species_10622176" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00016197", "O16785", "WBGene00003932", "Q09476", "WBGene00016197" ] }, "reaction_10620734": { "compartment": "compartment_70101", "id": "reaction_10620734", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620725", "species_10620730" ], "products": [ "species_10620732" ], "modifiers": [], "additional_components": [ "WBGene00000228", "WBGene00003932", "O16785", "WBGene00003932", "Q23158", "WBGene00000228" ] }, "reaction_10621028": { "compartment": "compartment_70101", "id": "reaction_10621028", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613387", "species_10620730" ], "products": [ "species_10621026" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10608576": { "compartment": "compartment_70101", "id": "reaction_10608576", "reactome": "R-CEL-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_29372", "species_10608574" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608461": { "compartment": "compartment_70101", "id": "reaction_10608461", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604177", "species_10602400" ], "products": [ "species_10608459" ], "modifiers": [], "additional_components": [ "WBGene00004928", "WBGene00004774", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608619": { "compartment": "compartment_70101", "id": "reaction_10608619", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10608459" ], "products": [ "species_10608549" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928" ] }, "reaction_10608535": { "compartment": "compartment_70101", "id": "reaction_10608535", "reactome": "R-CEL-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608497", "species_29356" ], "products": [ "species_10608503", "species_10608482", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "G5ECJ6", "WBGene00000812", "G5EE56", "WBGene00005077", "Q09476", "WBGene00016197", "WBGene00000812", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608547": { "compartment": "compartment_70101", "id": "reaction_10608547", "reactome": "R-CEL-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10608532" ], "products": [ "species_10608545", "species_29372" ], "modifiers": [ [ "species_10608532", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608597": { "compartment": "compartment_70101", "id": "reaction_10608597", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10608594", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608599": { "compartment": "compartment_70101", "id": "reaction_10608599", "reactome": "R-CEL-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10608551" ], "products": [ "species_10608553" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608559": { "compartment": "compartment_70101", "id": "reaction_10608559", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608553", "species_113592" ], "products": [ "species_29370", "species_10608530" ], "modifiers": [ [ "species_10608553", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "species_179838", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10617088": { "compartment": "compartment_984", "id": "reaction_10617088", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617085" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_10615845", "species_114523" ], "modifiers": [ [ "species_10617085", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617033": { "compartment": "compartment_374932", "id": "reaction_10617033", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10617091": { "compartment": "compartment_876", "id": "reaction_10617091", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10617083", "species_10614053", "species_10614048" ], "products": [ "species_10617085" ], "modifiers": [ [ "species_10617083", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "species_114523", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_114523", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10619748": { "compartment": "compartment_876", "id": "reaction_10619748", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10619743", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_109496", "species_74113", "species_74016", "species_109496", "P34586", "WBGene00006614", "species_114519", "G5EF09", "WBGene00004976" ] }, "reaction_10617308": { "compartment": "compartment_70101", "id": "reaction_10617308", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617306" ], "products": [ "species_29420", "species_10615172" ], "modifiers": [ [ "species_10617233", "catalyst" ], [ "species_10617202", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_111349", "Q18246", "WBGene00004307", "species_29438", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617235": { "compartment": "compartment_876", "id": "reaction_10617235", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617228": { "compartment": "compartment_12045", "id": "reaction_10617228", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617218" ], "products": [ "species_10617226" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10617204": { "compartment": "compartment_876", "id": "reaction_10617204", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617200", "species_30389" ], "products": [ "species_10617202" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10617304": { "compartment": "compartment_876", "id": "reaction_10617304", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617302" ], "products": [ "species_10617302" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "G5EC00", "WBGene00008819", "H2KZQ6", "WBGene00001374", "A0A3B1E007", "WBGene00004793", "J3K003", "WBGene00007862", "A0A4V0INI0", "WBGene00002242", "G5EFC3", "WBGene00001202", "Q20381", "WBGene00018402", "WBGene00002189" ] }, "reaction_10601861": { "compartment": "compartment_7660", "id": "reaction_10601861", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601855" ], "products": [ "species_10601775", "species_10601859" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "P48322", "WBGene00007980", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "WBGene00007980", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749" ] }, "reaction_10601779": { "compartment": "compartment_7660", "id": "reaction_10601779", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601775", "species_10601770" ], "products": [ "species_10601777" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q9U3I0", "WBGene00009078", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q9U3I0", "WBGene00009078", "P48322", "WBGene00007980", "Q9GR61", "WBGene00021347", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "Q9UAY9", "WBGene00019275", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999" ] }, "reaction_10602569": { "compartment": "compartment_350", "id": "reaction_10602569", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10601859", "catalyst" ], [ "species_10602567", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "K8F7X5", "WBGene00013529", "P46064", "WBGene00006430", "Q17684", "WBGene00007355", "Q27493", "WBGene00008781", "O17587", "WBGene00007616", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "G5ED21", "WBGene00012999", "Q95PZ4", "WBGene00013441", "O01914", "WBGene00017758", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9UAY9", "WBGene00019275", "Q95X83", "WBGene00017749", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "G5EET5", "WBGene00001995" ] }, "reaction_10637186": { "compartment": "compartment_876", "id": "reaction_10637186", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637182", "species_1297302" ], "products": [ "species_10637184" ], "modifiers": [], "additional_components": [ "WBGene00011923", "G5ECE8", "WBGene00011923", "species_1297302" ] }, "reaction_10637196": { "compartment": "compartment_876", "id": "reaction_10637196", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10637193", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10614415": { "compartment": "compartment_876", "id": "reaction_10614415", "reactome": "R-CEL-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614410" ], "products": [ "species_10608528", "species_10612190" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038" ] }, "reaction_10604456": { "compartment": "compartment_70101", "id": "reaction_10604456", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10602400" ], "products": [ "species_10602407" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10608588": { "compartment": "compartment_70101", "id": "reaction_10608588", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608585", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614408": { "compartment": "compartment_876", "id": "reaction_10614408", "reactome": "R-CEL-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608528", "species_10612156" ], "products": [ "species_10614406" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00004038", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608477": { "compartment": "compartment_876", "id": "reaction_10608477", "reactome": "R-CEL-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608473" ], "products": [ "species_10608475" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608603": { "compartment": "compartment_70101", "id": "reaction_10608603", "reactome": "R-CEL-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602407", "species_10608528" ], "products": [ "species_10608585" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608581": { "compartment": "compartment_70101", "id": "reaction_10608581", "reactome": "R-CEL-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608578", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10665754": { "compartment": "compartment_459", "id": "reaction_10665754", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10665750" ], "products": [ "species_10665752" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10608566": { "compartment": "compartment_70101", "id": "reaction_10608566", "reactome": "R-CEL-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608475", "species_113592" ], "products": [ "species_29370", "species_10608528" ], "modifiers": [ [ "species_10608475", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608612": { "compartment": "compartment_70101", "id": "reaction_10608612", "reactome": "R-CEL-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10608609", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10608601": { "compartment": "compartment_984", "id": "reaction_10608601", "reactome": "R-CEL-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10608471" ], "products": [ "species_10608473" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10614413": { "compartment": "compartment_70101", "id": "reaction_10614413", "reactome": "R-CEL-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614406", "species_113592" ], "products": [ "species_29370", "species_10614410" ], "modifiers": [ [ "species_10614406", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q22070", "WBGene00004038", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10598294": { "compartment": "compartment_70101", "id": "reaction_10598294", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598280", "species_10598290" ], "products": [ "species_10598292" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10609629": { "compartment": "compartment_7660", "id": "reaction_10609629", "reactome": "R-CEL-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10609624" ], "products": [ "species_113582", "species_10605292", "species_10598141" ], "modifiers": [ [ "species_10609624", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10609622": { "compartment": "compartment_7660", "id": "reaction_10609622", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10598298" ], "products": [ "species_113582", "species_10598141" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10609626": { "compartment": "compartment_7660", "id": "reaction_10609626", "reactome": "R-CEL-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598311", "species_10598141" ], "products": [ "species_10609624" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020" ] }, "reaction_10605940": { "compartment": "compartment_13231", "id": "reaction_10605940", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598292" ], "products": [ "species_10598298" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870" ] }, "reaction_10638555": { "compartment": "compartment_70101", "id": "reaction_10638555", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10638551" ], "products": [ "species_10638553" ], "modifiers": [], "additional_components": [ "WBGene00003405", "Q23255", "WBGene00003405", "species_874088" ] }, "reaction_10645205": { "compartment": "compartment_876", "id": "reaction_10645205", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645197" ], "products": [ "species_29370", "species_10645203" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "WBGene00005077" ] }, "reaction_10644469": { "compartment": "compartment_876", "id": "reaction_10644469", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642488", "species_112275" ], "products": [ "species_10644467" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10653154": { "compartment": "compartment_6799713", "id": "reaction_10653154", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653046" ], "products": [ "species_10653152" ], "modifiers": [], "additional_components": [ "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064", "Q20665", "WBGene00255469", "Q9N4W4", "WBGene00021602", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q22495", "WBGene00006638", "Q22799", "WBGene00001005", "O02495", "WBGene00004897", "H2KZY7", "WBGene00022283", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "Q17441", "WBGene00006646", "Q9N2U6", "WBGene00022402", "Q9XUF4", "WBGene00008203", "Q9XTY9", "WBGene00010993", "Q21146", "WBGene00019328", "P22981", "WBGene00002335", "Q9N5X7", "WBGene00016423", "G5EFM5", "WBGene00007729", "Q21557", "WBGene00010888", "Q9XX56", "WBGene00255469", "P34351", "WBGene00004899", "Q9XVI4", "WBGene00006633", "G4RWX0", "WBGene00006632", "Q65XS9", "WBGene00043067", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "A0A0S4XR36", "C44E4.1d", "O45275", "WBGene00007822", "Q19844", "WBGene00017865", "Q20707", "WBGene00006630", "O44827", "WBGene00019207", "Q17526", "WBGene00006637", "Q19983", "WBGene00006634", "Q93874", "WBGene00004276", "Q93323", "WBGene00007903", "Q5WRN9", "WBGene00023502", "Q9XVM9", "WBGene00006641", "Q21433", "WBGene00004877", "Q20325", "WBGene00018344", "Q95XG8", "WBGene00004878", "Q1ZXU1", "WBGene00044790", "O01312", "WBGene00004309", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "O17599", "WBGene00004308", "Q7YTJ8", "WBGene00012425", "G5EFD9", "WBGene00006324", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q9N4W5", "WBGene00021603", "Q18821", "WBGene00016912", "Q8WQG5", "WBGene00007390", "Q27874", "WBGene00003930", "Q21434", "WBGene00004876", "Q21750", "WBGene00019895", "P91214", "WBGene00017199", "O62466", "WBGene00006631", "H2L006", "WBGene00006640", "G5EFC7", "WBGene00011361", "U4PBV8", "WBGene00019166", "C0HLB4", "WBGene00006912", "Q9TYL9", "WBGene00021292", "O18076", "WBGene00011668", "A0AAC1", "WBGene00012424", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491", "Q19958", "WBGene00006064" ] }, "reaction_10644482": { "compartment": "compartment_876", "id": "reaction_10644482", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644480" ], "products": [ "species_10644471" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10625987": { "compartment": "compartment_70101", "id": "reaction_10625987", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625973" ], "products": [ "species_10625979", "species_10597908" ], "modifiers": [ [ "species_10625984", "catalyst" ] ], "additional_components": [ "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "WBGene00006727", "WBGene00009594" ] }, "reaction_10645210": { "compartment": "compartment_876", "id": "reaction_10645210", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10645207" ], "products": [ "species_29370", "species_10645197" ], "modifiers": [ [ "species_10617744", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10657872": { "compartment": "compartment_876", "id": "reaction_10657872", "reactome": "R-CEL-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657866", "species_10657868" ], "products": [ "species_10657870" ], "modifiers": [], "additional_components": [ "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10661671": { "compartment": "compartment_876", "id": "reaction_10661671", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627143", "species_10627117" ], "products": [ "species_10627145" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10655607": { "compartment": "compartment_984", "id": "reaction_10655607", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10655569" ], "products": [ "species_10655571" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10612177": { "compartment": "compartment_70101", "id": "reaction_10612177", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846", "species_112275" ], "products": [ "species_10612175" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644478": { "compartment": "compartment_876", "id": "reaction_10644478", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644467" ], "products": [ "species_10644476" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10644474": { "compartment": "compartment_876", "id": "reaction_10644474", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10644471", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10652445": { "compartment": "compartment_876", "id": "reaction_10652445", "reactome": "R-CEL-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652253" ], "products": [ "species_10652443" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421", "P91857", "WBGene00004268", "G5EC10", "WBGene00002272", "Q8MXS1", "WBGene00004277", "Q19930", "WBGene00017947", "Q1RS86", "WBGene00000020", "O44555", "WBGene00000111", "Q9U2T0", "WBGene00013786", "H2KYL1", "WBGene00018472", "A0A061AD52", "WBGene00255469", "Q965W1", "WBGene00021486", "Q9U2T1", "WBGene00013785", "O16652", "WBGene00020293", "Q9XUF4", "WBGene00008203", "Q9XW49", "WBGene00000023", "Q09946", "WBGene00017393", "O01330", "WBGene00235368", "P55163", "WBGene00001580", "Q9XX56", "WBGene00255469", "O01331", "WBGene00235368", "Q94215", "WBGene00002274", "Q9GZD9", "WBGene00235368", "O01329", "WBGene00235368", "Q22328", "WBGene00002976", "Q18813", "WBGene00235368", "G5EGS9", "WBGene00012206", "U4PM93", "WBGene00235368", "O45275", "WBGene00007822", "O44857", "WBGene00020230", "Q9GZD8", "WBGene00235368", "O44827", "WBGene00019207", "Q09581", "WBGene00002266", "O01812", "WBGene00002258", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q18849", "WBGene00008314", "Q20256", "WBGene00235368", "O16796", "WBGene00017557", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q18821", "WBGene00016912", "Q18673", "WBGene00013926", "Q22763", "WBGene00020788", "A0A1N7SYP5", "WBGene00009500", "P91214", "WBGene00017199", "Q09610", "WBGene00002271", "Q9U2I7", "WBGene00004165", "O16795", "WBGene00017550", "O18076", "WBGene00011668", "Q20684", "WBGene00002265", "O62403", "WBGene00013782", "Q20665", "WBGene00255469", "A0A5S9MNU9", "WBGene00017842", "G5ED36", "WBGene00004378", "Q9N4W4", "WBGene00021602", "D3KFV8", "WBGene00007820", "O01761", "WBGene00006820", "Q22782", "WBGene00004270", "O45569", "WBGene00010070", "P30628", "WBGene00006768", "O01814", "WBGene00002257", "O45311", "WBGene00016896", "G5EBV4", "WBGene00002273", "Q23146", "WBGene00004271", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "H2KZE5", "WBGene00018278", "Q4TT88", "WBGene00003914", "G5ED34", "WBGene00001007", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "G5EFM5", "WBGene00007729", "Q09277", "WBGene00235368", "O16607", "WBGene00016778", "Q23427", "WBGene00022874", "Q9GUM2", "WBGene00000269", "O17772", "WBGene00003980", "O16789", "WBGene00017554", "Q20748", "WBGene00010015", "G5ED52", "WBGene00014171", "Q5WRN9", "WBGene00023502", "Q94148", "WBGene00004273", "Q7JP75", "WBGene00000872", "Q1ZXU1", "WBGene00044790", "O16636", "WBGene00019343", "O44871", "WBGene00019914", "Q94986", "WBGene00004267", "F5GU58", "WBGene00235368", "Q22038", "WBGene00004357", "Q22601", "WBGene00000161", "Q03206", "ced-10", "Q19479", "WBGene00008848", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q20019", "WBGene00009401", "O16790", "WBGene00017555", "Q9TXV8", "WBGene00000022", "Q400M1", "WBGene00018196", "Q9N384", "WBGene00002269", "P34213", "WBGene00004269", "Q09605", "WBGene00002270", "Q9TYL9", "WBGene00021292", "Q18625", "WBGene00002267", "P34358", "WBGene00000421" ] }, "reaction_10612154": { "compartment": "compartment_70101", "id": "reaction_10612154", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_202277" ], "products": [ "species_10612152" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10655611": { "compartment": "compartment_984", "id": "reaction_10655611", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655569", "species_6789198" ], "products": [ "species_10655609" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "species_6789198" ] }, "reaction_10635413": { "compartment": "compartment_876", "id": "reaction_10635413", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10653778": { "compartment": "compartment_6799371", "id": "reaction_10653778", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653746" ], "products": [ "species_10653776" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q18825", "WBGene00000238", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O01824", "WBGene00019008", "O44131", "WBGene00015620", "G5EGP8", "WBGene00000788", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "Q23365", "WBGene00022627", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "Q18825", "WBGene00000238", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "O45539", "WBGene00005078", "A0A1X7RC97", "WBGene00020658", "Q93192", "WBGene00017055", "O44326", "WBGene00001979", "G5EBT9", "WBGene00010418", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "G5EFP4", "WBGene00006366", "O62390", "WBGene00194737", "Q966Q0", "WBGene00017376", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "G5ECY0", "WBGene00001006", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "Q304D5", "WBGene00016278", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q9BIB8", "WBGene00002075", "G5EEN3", "WBGene00000419", "Q21408", "WBGene00004951", "Q93565", "WBGene00006578", "G5EBU3", "WBGene00016283", "Q19202", "WBGene00017244", "P90920", "WBGene00010621", "Q10953", "WBGene00006943", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "G5EBS5", "WBGene00000089", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "G5EGP8", "WBGene00000788" ] }, "reaction_10655577": { "compartment": "compartment_984", "id": "reaction_10655577", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655571" ], "products": [ "species_10655575" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "CHEBI:62643", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10657844": { "compartment": "compartment_984", "id": "reaction_10657844", "reactome": "R-CEL-8852716", "name": "Thrombin, ELANE cleave C5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607933" ], "products": [ "species_10607947", "species_10657842" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10656550": { "compartment": "compartment_984", "id": "reaction_10656550", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10656546" ], "products": [ "species_10656548" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "species_166005", "O44131", "WBGene00015620" ] }, "reaction_10653606": { "compartment": "compartment_1462052", "id": "reaction_10653606", "reactome": "R-CEL-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10653432" ], "products": [ "species_10653604" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "P91060", "WBGene00015841", "Q22253", "WBGene00004465", "P54216", "WBGene00011474", "Q9TZM2", "WBGene00020858", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "Q20616", "WBGene00009897", "O62102", "WBGene00003948", "Q18787", "WBGene00004501", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "Q20938", "WBGene00004462", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q95008", "WBGene00003926", "Q09390", "WBGene00001972", "O76371", "WBGene00004505", "P46941", "WBGene00008006", "O17365", "WBGene00005643", "P54812", "WBGene00008053", "P91455", "WBGene00020557", "P29691", "WBGene00001167", "O61861", "WBGene00000205", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EE40", "WBGene00005642", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "Q9GZH5", "WBGene00004458", "P34288", "WBGene00015418", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "K8F7Z5", "WBGene00008735", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "G5EE56", "WBGene00005077", "Q23490", "WBGene00022743", "O18211", "WBGene00013140", "H9G2T4", "WBGene00010317", "O61792", "WBGene00004464", "G5EF80", "WBGene00014051", "O76577", "WBGene00004467", "H2KZ53", "WBGene00017968", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "O44514", "WBGene00004057", "Q21829", "WBGene00000520", "Q9N358", "WBGene00021934", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "Q17446", "WBGene00004055", "Q19440", "WBGene00008780", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q9U2D2", "WBGene00000519", "O44518", "WBGene00001579", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "G5ED41", "WBGene00013606", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "Q2V4S2", "WBGene00001558", "Q7K707", "WBGene00013597", "Q1ENI8", "WBGene00004256", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230", "G5EG78", "WBGene00004257", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q9XUT0", "WBGene00010664", "Q65XX1", "WBGene00006888", "Q7YTU0", "WBGene00013969", "Q27488", "WBGene00003923", "O01824", "WBGene00019008", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "U4PME4", "WBGene00044760" ] }, "reaction_10628353": { "compartment": "compartment_876", "id": "reaction_10628353", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627119", "species_10627117" ], "products": [ "species_10627121" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "WBGene00009500", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10654208": { "compartment": "compartment_1470028", "id": "reaction_10654208", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654040" ], "products": [ "species_10654206" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837", "P91060", "WBGene00015841", "Q9N5B3", "WBGene00021088", "Q23365", "WBGene00022627", "O02096", "WBGene00015975", "O17271", "WBGene00006452", "O44578", "WBGene00022808", "Q20616", "WBGene00009897", "O01814", "WBGene00002257", "Q18817", "WBGene00000248", "Q965W1", "WBGene00021486", "P49713", "WBGene00012225", "P54812", "WBGene00008053", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O45539", "WBGene00005078", "Q21697", "WBGene00019867", "Q19020", "WBGene00000962", "A0A1X7RC97", "WBGene00020658", "P52716", "WBGene00017969", "Q95Q32", "WBGene00013693", "Q20829", "WBGene00018877", "G5EE40", "WBGene00005642", "P53585", "WBGene00016995", "O76632", "WBGene00019225", "Q21801", "WBGene00011095", "B1GRL5", "WBGene00077643", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "G5EF01", "WBGene00006539", "K8F7Z5", "WBGene00008735", "O45520", "WBGene00009708", "Q23490", "WBGene00022743", "O45628", "WBGene00010433", "O02106", "WBGene00021095", "P47207", "WBGene00000378", "P34722", "WBGene00006599", "P52717", "WBGene00018271", "G5EF80", "WBGene00014051", "Q22492", "WBGene00020509", "H2KZ53", "WBGene00017968", "Q8MXT1", "WBGene00021401", "Q95XX1", "WBGene00021882", "Q9N358", "WBGene00021934", "Q93565", "WBGene00006578", "O01812", "WBGene00002258", "P53489", "WBGene00000200", "O61887", "WBGene00019624", "P52275", "WBGene00006537", "Q9XVQ1", "WBGene00009708", "Q21882", "WBGene00022808", "P39745", "WBGene00003401", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "Q2V4S2", "WBGene00001558", "Q9TYS3", "WBGene00001501", "Q18115", "WBGene00004459", "G5EEU3", "WBGene00000084", "Q1ENI8", "WBGene00004256", "P52715", "WBGene00008741", "Q9GYR2", "WBGene00016793", "Q21925", "WBGene00011239", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "O76725", "WBGene00021503", "G5ECY2", "WBGene00005644", "Q95YA9", "WBGene00000294", "G5EG78", "WBGene00004257", "P52714", "WBGene00007462", "P41937", "WBGene00006538", "Q7YTU0", "WBGene00013969", "Q09991", "WBGene00019605", "Q9GZH3", "WBGene00020682", "O17921", "WBGene00006536", "O16453", "WBGene00001500", "Q400L7", "WBGene00018837" ] }, "reaction_10627062": { "compartment": "compartment_984", "id": "reaction_10627062", "reactome": "R-CEL-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627056", "species_10627058" ], "products": [ "species_10627060" ], "modifiers": [], "additional_components": [ "WBGene00006619", "WBGene00006619", "Q23528", "WBGene00006619" ] }, "reaction_10637568": { "compartment": "compartment_876", "id": "reaction_10637568", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637562" ], "products": [ "species_29370", "species_10637565" ], "modifiers": [ [ "species_10637562", "catalyst" ] ], "additional_components": [ "WBGene00005077", "WBGene00005077", "WBGene00005077" ] }, "reaction_10663891": { "compartment": "compartment_70101", "id": "reaction_10663891", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638461", "species_8982080" ], "products": [ "species_10663889" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10635404": { "compartment": "compartment_876", "id": "reaction_10635404", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10635401", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256", "G5EDU3", "WBGene00004040" ] }, "reaction_10657864": { "compartment": "compartment_984", "id": "reaction_10657864", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657846" ], "products": [ "species_10657848" ], "modifiers": [ [ "species_10657861", "catalyst" ] ], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q9N5D7", "WBGene00020693", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593" ] }, "reaction_10637988": { "compartment": "compartment_984", "id": "reaction_10637988", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607167" ], "products": [ "species_10627129" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10645212": { "compartment": "compartment_876", "id": "reaction_10645212", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10607837" ], "products": [ "species_10645207" ], "modifiers": [], "additional_components": [ "WBGene00003030", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10655475": { "compartment": "compartment_984", "id": "reaction_10655475", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655427" ], "products": [ "species_10655473" ], "modifiers": [], "additional_components": [ "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "G5ECC4", "WBGene00020646", "Q9TZM2", "WBGene00020858", "Q18825", "WBGene00000238", "O62102", "WBGene00003948", "Q9N4A5", "WBGene00022306", "Q18688", "WBGene00000915", "P34664", "WBGene00022785", "P43510", "WBGene00000786", "Q09665", "WBGene00006583", "P09446", "WBGene00002005", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q9U228", "WBGene00003234", "P34286", "WBGene00003952", "Q09390", "WBGene00001972", "Q21265", "WBGene00019478", "O76371", "WBGene00004505", "O17365", "WBGene00005643", "Q27526", "WBGene00011832", "P29691", "WBGene00001167", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q8MXI4", "WBGene00004056", "B7WNA0", "WBGene00009126", "Q95Q32", "WBGene00013693", "U4PSA1", "WBGene00019298", "Q20603", "WBGene00009895", "G5EBT9", "WBGene00010418", "G5EE40", "WBGene00005642", "Q9GZH5", "WBGene00004458", "Q21966", "WBGene00000217", "P53585", "WBGene00016995", "P04630", "WBGene00000285", "Q21004", "WBGene00010272", "Q2AAB9", "WBGene00044760", "Q9U2S6", "WBGene00000889", "Q04908", "WBGene00004460", "O62390", "WBGene00194737", "A9Z1L1", "WBGene00005648", "G5EBK4", "WBGene00010882", "O45520", "WBGene00009708", "O18211", "WBGene00013140", "Q8IAA9", "WBGene00000545", "H9G2T4", "WBGene00010317", "O62349", "WBGene00011253", "O76577", "WBGene00004467", "O44514", "WBGene00004057", "Q9N358", "WBGene00021934", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "Q9XVQ1", "WBGene00009708", "Q8MYL7", "WBGene00013220", "Q20911", "WBGene00013855", "Q9TYX1", "WBGene00001058", "Q21643", "WBGene00019827", "G5ECU5", "WBGene00009691", "Q9BL26", "WBGene00044760", "O45934", "WBGene00012803", "O02329", "WBGene00011971", "Q7K707", "WBGene00013597", "Q93377", "WBGene00008093", "U4PBQ7", "WBGene00015250", "Q09980", "WBGene00017394", "Q27483", "WBGene00008230", "Q23539", "WBGene00014001", "Q9XU15", "WBGene00010416", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "Q27488", "WBGene00003923", "P46563", "WBGene00017166", "Q9GZH3", "WBGene00020682", "O16305", "WBGene00000552", "U4PME4", "WBGene00044760", "O16927", "WBGene00017799", "Q22253", "WBGene00004465", "Q18136", "WBGene00006861", "O45686", "WBGene00010769", "Q9N4B2", "WBGene00000546", "Q21253", "WBGene00010593", "Q9U2Z5", "WBGene00013724", "O17913", "WBGene00010423", "Q18787", "WBGene00004501", "P46551", "WBGene00007135", "Q20938", "WBGene00004462", "Q95008", "WBGene00003926", "O02159", "WBGene00020378", "P54812", "WBGene00008053", "O61861", "WBGene00000205", "G5EDZ8", "WBGene00000288", "G5ECM9", "WBGene00000534", "O44326", "WBGene00001979", "O62334", "WBGene00011050", "P19826", "WBGene00000942", "G5EFP4", "WBGene00006366", "O76632", "WBGene00019225", "G5EEG0", "WBGene00000286", "Q93576", "WBGene00009119", "Q9NA98", "WBGene00013168", "Q23227", "WBGene00012364", "O61792", "WBGene00004464", "Q21267", "WBGene00019476", "Q94288", "WBGene00000287", "G5EFT4", "WBGene00016589", "Q9U2B2", "WBGene00000544", "Q9N4B1", "WBGene00000547", "Q9BIB8", "WBGene00002075", "Q20628", "WBGene00000392", "P10299", "WBGene00001749", "Q19264", "WBGene00017283", "U4PBY0", "WBGene00022069", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q8IAA5", "WBGene00021758", "A0A2C9C377", "WBGene00016415", "P91167", "WBGene00016729", "P53489", "WBGene00000200", "Q17446", "WBGene00004055", "Q10953", "WBGene00006943", "Q19440", "WBGene00008780", "Q9U2D2", "WBGene00000519", "Q22075", "WBGene00011345", "Q19416", "WBGene00008764", "P53013", "WBGene00001168", "P34308", "WBGene00000542", "G5ED41", "WBGene00013606", "P39745", "WBGene00003401", "Q9TYS3", "WBGene00001501", "Q9GYR2", "WBGene00016793", "Q19324", "WBGene00004461", "P28548", "WBGene00002196", "G5ECY2", "WBGene00005644", "Q20585", "WBGene00004463", "Q9TZL8", "WBGene00022199", "G5EF37", "WBGene00003934", "A0A0K3ARD1", "WBGene00194737", "Q65XX1", "WBGene00006888", "G5EGP8", "WBGene00000788" ] }, "reaction_10610934": { "compartment": "compartment_876", "id": "reaction_10610934", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610919" ], "products": [ "species_29370", "species_10610931" ], "modifiers": [ [ "species_10610919", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10637560": { "compartment": "compartment_70101", "id": "reaction_10637560", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10637558" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10607959": { "compartment": "compartment_984", "id": "reaction_10607959", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10607181" ], "products": [ "species_10607957" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627220": { "compartment": "compartment_876", "id": "reaction_10627220", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607189" ], "products": [ "species_10627119" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627236": { "compartment": "compartment_876", "id": "reaction_10627236", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10607167" ], "products": [ "species_10627143" ], "modifiers": [], "additional_components": [ "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627155": { "compartment": "compartment_876", "id": "reaction_10627155", "reactome": "R-CEL-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627060", "species_10627151" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10627210": { "compartment": "compartment_876", "id": "reaction_10627210", "reactome": "R-CEL-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_10627185", "species_10627060", "species_10627183", "species_10627207" ], "modifiers": [ [ "species_10627153", "catalyst" ] ], "additional_components": [ "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q22328", "WBGene00002976", "Q23528", "WBGene00006619", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619", "Q18849", "WBGene00008314", "A0A1N7SYP5", "WBGene00009500", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735" ] }, "reaction_10652817": { "compartment": "compartment_6800173", "id": "reaction_10652817", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10652705" ], "products": [ "species_10652815" ], "modifiers": [], "additional_components": [ "Q4W5T6", "WBGene00044310", "P37806", "WBGene00006819", "Q19312", "WBGene00008656", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760", "Q4W5T6", "WBGene00044310", "Q19312", "WBGene00008656", "P37806", "WBGene00006819", "P54216", "WBGene00011474", "O44836", "WBGene00019212", "O45686", "WBGene00010769", "G5ECC4", "WBGene00020646", "Q19349", "WBGene00017376", "Q23050", "WBGene00020808", "G5EC24", "WBGene00004214", "O17913", "WBGene00010423", "Q9U3A0", "WBGene00003915", "Q21742", "WBGene00019890", "G5EGE7", "WBGene00022129", "Q21265", "WBGene00019478", "G5ECM9", "WBGene00000534", "Q93192", "WBGene00017055", "G5EBT9", "WBGene00010418", "Q21966", "WBGene00000217", "H2KZY5", "WBGene00018533", "Q20587", "WBGene00044310", "G5EFP4", "WBGene00006366", "Q2AAB9", "WBGene00044760", "Q966Q0", "WBGene00017376", "O62390", "WBGene00194737", "O44788", "WBGene00000778", "Q19137", "WBGene00008543", "Q23227", "WBGene00012364", "Q93193", "WBGene00017055", "G5EBT7", "WBGene00000583", "H9G2T4", "WBGene00010317", "Q21267", "WBGene00019476", "O62349", "WBGene00011253", "G5EFT4", "WBGene00016589", "Q09936", "WBGene00016898", "Q95X90", "WBGene00017055", "Q22993", "WBGene00018811", "Q20628", "WBGene00000392", "Q21408", "WBGene00004951", "O17255", "WBGene00044760", "G5EBU3", "WBGene00016283", "Q9U204", "WBGene00013323", "P90920", "WBGene00010621", "Q19202", "WBGene00017244", "G5EGP1", "WBGene00006845", "O44518", "WBGene00001579", "Q22075", "WBGene00011345", "Q20911", "WBGene00013855", "Q9BL26", "WBGene00044760", "Q9TYS3", "WBGene00001501", "O02329", "WBGene00011971", "Q93377", "WBGene00008093", "Q7YX44", "WBGene00017055", "U4PBQ7", "WBGene00015250", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "Q9XUT0", "WBGene00010664", "P46563", "WBGene00017166", "U4PME4", "WBGene00044760" ] }, "reaction_10635284": { "compartment": "compartment_70101", "id": "reaction_10635284", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635282", "species_113592" ], "products": [ "species_29370", "species_10618297", "species_10617721" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00003911" ] }, "reaction_10655079": { "compartment": "compartment_6800424", "id": "reaction_10655079", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655055" ], "products": [ "species_10655077" ], "modifiers": [], "additional_components": [ "Q20684", "WBGene00002265", "Q9U308", "WBGene00002175", "Q20665", "WBGene00255469", "G5EC10", "WBGene00002272", "Q9N4W4", "WBGene00021602", "G5EFD5", "WBGene00006804", "D3KFV8", "WBGene00007820", "Q19930", "WBGene00017947", "Q22799", "WBGene00001005", "Q9GYK0", "WBGene00015471", "P30628", "WBGene00006768", "G5EDW5", "WBGene00000074", "A0A061AD52", "WBGene00255469", "G5EBV4", "WBGene00002273", "Q9XTY9", "WBGene00010993", "Q9XUF4", "WBGene00008203", "Q19833", "WBGene00017837", "G5EDC6", "WBGene00000192", "Q20549", "WBGene00235368", "G5ECX0", "WBGene00002252", "Q17540", "WBGene00015283", "Q21146", "WBGene00019328", "Q53U87", "WBGene00004732", "G5ED34", "WBGene00001007", "O44873", "WBGene00019915", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "Q9N5X7", "WBGene00016423", "G5EFI4", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10607104" ], "products": [ "species_10655831" ], "modifiers": [], "additional_components": [ "WBGene00022627", "species_166005", "Q23365", "WBGene00022627" ] }, "reaction_10654694": { "compartment": "compartment_6799351", "id": "reaction_10654694", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00006633", "P34462", "WBGene00010130", "Q95QY6", "WBGene00022014", "Q95XH1", "WBGene00022077", "P34446", "WBGene00003929", "Q9NCE1", "WBGene00010408", "G5EBK2", "WBGene00014084", "Q22908", "WBGene00016344", "O44186", "WBGene00017996", "G5EC93", "WBGene00022014", "Q21228", "WBGene00018527", "Q19878", "WBGene00009218", "O44616", "WBGene00022014", "Q20707", "WBGene00006630", "Q19983", "WBGene00006634", "Q93323", "WBGene00007903", "O45920", "WBGene00022014", "Q5WRN9", "WBGene00023502", "P83386", "WBGene00018527", "Q9XVM9", "WBGene00006641", "G5EGM1", "WBGene00006987", "G5EC63", "WBGene00013197", "Q1ZXU1", "WBGene00044790", "O44871", "WBGene00019914", "G5EDU3", "WBGene00004040", "G5EFD9", "WBGene00006324", "A0A486WWU7", "WBGene00000110", "Q9N4W5", "WBGene00021603", "Q23535", "WBGene00006865", "A0A4V0IKG6", "WBGene00007287", "O62466", "WBGene00006631", "Q11114", "WBGene00022014", "Q19767", "WBGene00004898", "Q5WRN1", "WBGene00023491" ] }, "reaction_10639131": { "compartment": "compartment_876", "id": "reaction_10639131", "reactome": "R-CEL-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639108" ], "products": [ "species_10627115", "species_10639128", "species_10639122" ], "modifiers": [ [ "species_10627060", "catalyst" ] ], "additional_components": [ "Q18849", "WBGene00008314", "Q7YTU0", "WBGene00013969", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q18849", "WBGene00008314", "Q22328", "WBGene00002976", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q23528", "WBGene00006619" ] }, "reaction_10651831": { "compartment": "compartment_6798757", "id": "reaction_10651831", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651701" ], "products": [ "species_10651829" ], "modifiers": [], "additional_components": [ "P45971", "WBGene00011638", "E5QCE7", "WBGene00001032", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "Q18276", "WBGene00004995", "X5LV99", "WBGene00019346", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421", "E5QCE7", "WBGene00001032", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "E7EM30", "WBGene00206373", "O76735", "WBGene00004912", "Q93324", "WBGene00007904", "P52166", "WBGene00004769", "Q1RS86", "WBGene00000020", "Q9GYK0", "WBGene00015471", "O02495", "WBGene00004897", "O02100", "WBGene00001985", "Q22630", "WBGene00011879", "Q19076", "WBGene00004020", "O17373", "WBGene00020471", "Q01608", "WBGene00004958", "Q09448", "WBGene00007328", "G5EDC6", "WBGene00000192", "Q9BL33", "WBGene00022169", "Q9XW49", "WBGene00000023", "Q18864", "WBGene00004788", "P34351", "WBGene00004899", "P34676", "WBGene00022801", "Q95XH1", "WBGene00022077", "Q19175", "WBGene00008560", "G5EGS9", "WBGene00012206", "G5EBK2", "WBGene00014084", "Q22525", "WBGene00004023", "P90949", "WBGene00011262", "Q11117", "WBGene00003053", "Q22908", "WBGene00016344", "Q9GUM2", "WBGene00000269", "Q21228", "WBGene00018527", "P83386", "WBGene00018527", "Q18582", "WBGene00018527", "Q94986", "WBGene00004267", "Q18246", "WBGene00004307", "Q9U280", "WBGene00013034", "Q94057", "WBGene00044062", "C0HLB3", "WBGene00006911", "X5LV99", "WBGene00019346", "Q18276", "WBGene00004995", "P83387", "WBGene00018527", "Q19390", "WBGene00017427", "P34669", "WBGene00022793", "Q93411", "WBGene00018527", "Q9BL40", "WBGene00022181", "Q10944", "WBGene00015161", "Q9XWC5", "WBGene00013499", "Q09451", "WBGene00007331", "E7EM29", "WBGene00016152", "Q9TXV8", "WBGene00000022", "Q9GUF1", "WBGene00022246", "X5LPS1", "WBGene00019346", "Q20662", "WBGene00018696", "Q9GUF2", "WBGene00022245", "Q23316", "WBGene00000148", "P91245", "WBGene00017385", "O44782", "WBGene00018008", "C0HLB4", "WBGene00006912", "P83351", "WBGene00019305", "Q19767", "WBGene00004898", "Q19958", "WBGene00006064", "H2L0H3", "WBGene00019946", "Q95QX5", "WBGene00015561", "P34358", "WBGene00000421" ] }, "reaction_10665782": { "compartment": "compartment_70101", "id": "reaction_10665782", "reactome": "R-CEL-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10607014" ], "products": [ "species_10665780" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "O45418", "WBGene00001431", "species_9678991", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10629435": { "compartment": "compartment_876", "id": "reaction_10629435", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629432", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10629464": { "compartment": "compartment_876", "id": "reaction_10629464", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629461", "catalyst" ] ], "additional_components": [ "O17697", "WBGene00008265", "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176" ] }, "reaction_10610716": { "compartment": "compartment_876", "id": "reaction_10610716", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609937", "species_10609928" ], "products": [ "species_10609939" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10610718": { "compartment": "compartment_876", "id": "reaction_10610718", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609921", "species_10609926" ], "products": [ "species_10609928" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "P10984", "WBGene00000064", "WBGene00000894", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10666007": { "compartment": "compartment_7660", "id": "reaction_10666007", "reactome": "R-CEL-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10666001" ], "products": [ "species_10665989", "species_427486" ], "modifiers": [ [ "species_10628319", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00001834" ] }, "reaction_10666004": { "compartment": "compartment_70101", "id": "reaction_10666004", "reactome": "R-CEL-9701531", "name": "p-Y705,S727 STAT3 is acetylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10665989" ], "products": [ "species_2485002", "species_10666001" ], "modifiers": [ [ "species_10628901", "catalyst" ] ], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "WBGene00000366" ] }, "reaction_10623765": { "compartment": "compartment_876", "id": "reaction_10623765", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623760": { "compartment": "compartment_876", "id": "reaction_10623760", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10621827": { "compartment": "compartment_876", "id": "reaction_10621827", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10621824", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623751": { "compartment": "compartment_876", "id": "reaction_10623751", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623756": { "compartment": "compartment_876", "id": "reaction_10623756", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10623753", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623767": { "compartment": "compartment_876", "id": "reaction_10623767", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10623762", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10623758": { "compartment": "compartment_876", "id": "reaction_10623758", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10623748", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q09369", "WBGene00000178", "O46024", "WBGene00000179", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172", "Q17571", "WBGene00000170", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10643263": { "compartment": "compartment_70101", "id": "reaction_10643263", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10643259" ], "products": [ "species_10643261" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10663022": { "compartment": "compartment_70101", "id": "reaction_10663022", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663018" ], "products": [ "species_29368", "species_10663016" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185" ] }, "reaction_10663249": { "compartment": "compartment_70101", "id": "reaction_10663249", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643261" ], "products": [ "species_29368", "species_10643259" ], "modifiers": [], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185" ] }, "reaction_10663020": { "compartment": "compartment_70101", "id": "reaction_10663020", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10663016" ], "products": [ "species_10663018" ], "modifiers": [], "additional_components": [ "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185" ] }, "reaction_10619462": { "compartment": "compartment_876", "id": "reaction_10619462", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_111627" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10619459", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619469": { "compartment": "compartment_876", "id": "reaction_10619469", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_352022", "species_425425", "species_74113" ], "products": [ "species_83910", "species_351626", "species_111627", "species_188972" ], "modifiers": [ [ "species_10619464", "catalyst" ] ], "additional_components": [ "WBGene00009920" ] }, "reaction_10619454": { "compartment": "compartment_876", "id": "reaction_10619454", "reactome": "R-CEL-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10619447", "catalyst" ] ], "additional_components": [ "WBGene00019844" ] }, "reaction_10647253": { "compartment": "compartment_70101", "id": "reaction_10647253", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647189" ], "products": [ "species_10647227", "species_29372" ], "modifiers": [ [ "species_10647250", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "Q10038", "WBGene00006923", "V6CIV8", "WBGene00003043", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10605081": { "compartment": "compartment_70101", "id": "reaction_10605081", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605072" ], "products": [ "species_29370", "species_10604506" ], "modifiers": [ [ "species_10605078", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10647195": { "compartment": "compartment_7660", "id": "reaction_10647195", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647189" ], "products": [ "species_10647193" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10604479": { "compartment": "compartment_70101", "id": "reaction_10604479", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604463", "species_10604475" ], "products": [ "species_10604477" ], "modifiers": [], "additional_components": [ "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665" ] }, "reaction_10604510": { "compartment": "compartment_70101", "id": "reaction_10604510", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604477" ], "products": [ "species_29370", "species_10604501" ], "modifiers": [ [ "species_10604477", "catalyst" ], [ "species_10604506", "inhibitor" ] ], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186" ] }, "reaction_10604522": { "compartment": "compartment_70101", "id": "reaction_10604522", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604501" ], "products": [ "species_10604463", "species_10604499" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "U4PDY6", "WBGene00019665", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10638746": { "compartment": "compartment_70101", "id": "reaction_10638746", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622515" ], "products": [ "species_29370", "species_10622458" ], "modifiers": [ [ "species_10638729", "catalyst" ] ], "additional_components": [ "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034", "WBGene00003822" ] }, "reaction_10638836": { "compartment": "compartment_7660", "id": "reaction_10638836", "reactome": "R-CEL-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638821", "species_29358" ], "products": [ "species_113582", "species_10638833" ], "modifiers": [ [ "species_10638821", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681" ] }, "reaction_10662912": { "compartment": "compartment_7660", "id": "reaction_10662912", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10638719" ], "products": [ "species_10638721" ], "modifiers": [], "additional_components": [ "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638742": { "compartment": "compartment_70101", "id": "reaction_10638742", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638731", "species_1250243" ], "products": [ "species_10638729", "species_10601705" ], "modifiers": [ [ "species_10638736", "catalyst" ] ], "additional_components": [ "O45017", "WBGene00020917", "Q21029", "WBGene00003822", "WBGene00003822", "WBGene00020917", "WBGene00003247" ] }, "reaction_10638724": { "compartment": "compartment_7660", "id": "reaction_10638724", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10638705" ], "products": [ "species_159939", "species_10638707" ], "modifiers": [ [ "species_10638721", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "species_113531", "Q95QK3", "WBGene00017571", "Q19760", "WBGene00009089" ] }, "reaction_10638823": { "compartment": "compartment_7660", "id": "reaction_10638823", "reactome": "R-CEL-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638819" ], "products": [ "species_113582", "species_10638821" ], "modifiers": [ [ "species_10622472", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU8", "WBGene00018035", "Q8MPS3", "WBGene00022613", "Q58AU7", "WBGene00018034" ] }, "reaction_10638839": { "compartment": "compartment_7660", "id": "reaction_10638839", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638707", "species_77087" ], "products": [ "species_77502", "species_10638705" ], "modifiers": [ [ "species_10614316", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036" ] }, "reaction_10621550": { "compartment": "compartment_70101", "id": "reaction_10621550", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615234" ], "products": [ "species_10621548" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00005077", "G5EE56", "WBGene00005077", "Q07292", "WBGene00003030" ] }, "reaction_10621571": { "compartment": "compartment_70101", "id": "reaction_10621571", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10621567" ], "products": [ "species_10621569" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10613690": { "compartment": "compartment_70101", "id": "reaction_10613690", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10613687", "catalyst" ] ], "additional_components": [ "species_113531", "G5EED8", "WBGene00006600" ] }, "reaction_10613711": { "compartment": "compartment_70101", "id": "reaction_10613711", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10597831": { "compartment": "compartment_7660", "id": "reaction_10597831", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597827", "species_10597822" ], "products": [ "species_10597829" ], "modifiers": [], "additional_components": [ "WBGene00012935", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158" ] }, "reaction_10630180": { "compartment": "compartment_7660", "id": "reaction_10630180", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10630172" ], "products": [ "species_113582", "species_10630164" ], "modifiers": [ [ "species_10630177", "catalyst" ] ], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10630243": { "compartment": "compartment_7660", "id": "reaction_10630243", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628748" ], "products": [ "species_10630241" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10597751": { "compartment": "compartment_7660", "id": "reaction_10597751", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597742", "species_10597721" ], "products": [ "species_10597744" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "C7IVS4", "WBGene00012936", "Q22798", "WBGene00020823", "Q21625", "WBGene00001002" ] }, "reaction_10605320": { "compartment": "compartment_7660", "id": "reaction_10605320", "reactome": "R-CEL-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10605292" ], "products": [ "species_113550", "species_10605294" ], "modifiers": [ [ "species_10605317", "catalyst" ] ], "additional_components": [ "WBGene00003020", "G5EDT1", "WBGene00003020", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10605322": { "compartment": "compartment_7660", "id": "reaction_10605322", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598113" ], "products": [ "species_113656", "species_10597721" ], "modifiers": [], "additional_components": [ "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002", "O02334", "WBGene00004181", "P34471", "WBGene00004180", "C7IVS4", "WBGene00012936", "Q21625", "WBGene00001002" ] }, "reaction_10628796": { "compartment": "compartment_7660", "id": "reaction_10628796", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10628319" ], "products": [ "species_10628794" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "WBGene00001834", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10597837": { "compartment": "compartment_7660", "id": "reaction_10597837", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597829" ], "products": [ "species_10597780", "species_10597835" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "O16297", "WBGene00003159", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XXI9", "WBGene00003154", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "P34647", "WBGene00003158", "WBGene00000413", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "Q9U2C2", "WBGene00012935", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10630247": { "compartment": "compartment_7660", "id": "reaction_10630247", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628784" ], "products": [ "species_10630245" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10628800": { "compartment": "compartment_7660", "id": "reaction_10628800", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628319", "species_10628784" ], "products": [ "species_10628798" ], "modifiers": [], "additional_components": [ "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O17695", "WBGene00001834", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10598120": { "compartment": "compartment_7660", "id": "reaction_10598120", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597740", "species_68419" ], "products": [ "species_10597742" ], "modifiers": [], "additional_components": [ "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q22798", "WBGene00020823" ] }, "reaction_10630168": { "compartment": "compartment_7660", "id": "reaction_10630168", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630164", "species_10628773" ], "products": [ "species_10630166" ], "modifiers": [], "additional_components": [ "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "P30630", "WBGene00002998", "Q95QD7", "WBGene00003037", "Q23482", "WBGene00003022", "G5EDT1", "WBGene00003020", "P90916", "WBGene00003036", "Q10120", "WBGene00003035", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161" ] }, "reaction_10630251": { "compartment": "compartment_7660", "id": "reaction_10630251", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630235", "species_10628782" ], "products": [ "species_10630249" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "WBGene00003020", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10630239": { "compartment": "compartment_7660", "id": "reaction_10630239", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628773", "species_10630235" ], "products": [ "species_10630237" ], "modifiers": [], "additional_components": [ "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "G5EF11", "WBGene00001161", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9U2M5", "WBGene00000870", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "H2L0L4", "WBGene00020461", "A5HWA8", "WBGene00001162", "P34638", "WBGene00000863", "G5EF11", "WBGene00001161" ] }, "reaction_10638114": { "compartment": "compartment_7660", "id": "reaction_10638114", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638089" ], "products": [ "species_10638074" ], "modifiers": [ [ "species_10638111", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10641285": { "compartment": "compartment_7660", "id": "reaction_10641285", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10602463" ], "products": [ "species_10641283", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "P62784", "WBGene00001875", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641349": { "compartment": "compartment_7660", "id": "reaction_10641349", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628319" ], "products": [ "species_10638173", "species_10641347" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "WBGene00006706", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641371": { "compartment": "compartment_7660", "id": "reaction_10641371", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628321" ], "products": [ "species_10641369", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001834", "O17695", "WBGene00001834", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641338": { "compartment": "compartment_7660", "id": "reaction_10641338", "reactome": "R-CEL-4615872", "name": "RANBP2 SUMOylates HDAC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641328", "species_10638181" ], "products": [ "species_10638173", "species_10641336" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00001837", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "P55853", "WBGene00004888", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10662809": { "compartment": "compartment_7660", "id": "reaction_10662809", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640202", "species_10638181" ], "products": [ "species_10662801", "species_10638173" ], "modifiers": [ [ "species_10662806", "catalyst" ] ], "additional_components": [ "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "WBGene00006706", "WBGene00010704" ] }, "reaction_10604149": { "compartment": "compartment_70101", "id": "reaction_10604149", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_83910", "species_179743" ], "modifiers": [ [ "species_10604146", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10665056": { "compartment": "compartment_876", "id": "reaction_10665056", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10624695": { "compartment": "compartment_20699", "id": "reaction_10624695", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10624692", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10604142": { "compartment": "compartment_70101", "id": "reaction_10604142", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10610539": { "compartment": "compartment_876", "id": "reaction_10610539", "reactome": "R-CEL-194130", "name": "Transport (influx) of bile salts and acids by OATP-A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192483" ], "products": [ "species_194156" ], "modifiers": [ [ "species_10610536", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10610509": { "compartment": "compartment_876", "id": "reaction_10610509", "reactome": "R-CEL-194079", "name": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10606540": { "compartment": "compartment_70616", "id": "reaction_10606540", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10606537", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10625070": { "compartment": "compartment_876", "id": "reaction_10625070", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10625067", "catalyst" ] ], "additional_components": [ "CHEBI:63836", "species_176496", "species_176501", "CHEBI:63836", "species_176496", "species_176501", "WBGene00018566" ] }, "reaction_10610520": { "compartment": "compartment_876", "id": "reaction_10610520", "reactome": "R-CEL-194083", "name": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194117" ], "products": [ "species_194097" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10625124": { "compartment": "compartment_876", "id": "reaction_10625124", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10625121", "catalyst" ] ], "additional_components": [ "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346", "Q9XWC5", "WBGene00013499" ] }, "reaction_10625088": { "compartment": "compartment_876", "id": "reaction_10625088", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10625085", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q9XWC5", "WBGene00013499" ] }, "reaction_10604129": { "compartment": "compartment_70101", "id": "reaction_10604129", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10604154": { "compartment": "compartment_70101", "id": "reaction_10604154", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83927", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00017867" ] }, "reaction_10604131": { "compartment": "compartment_70101", "id": "reaction_10604131", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10604124", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_83962", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83951", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "WBGene00009499" ] }, "reaction_10625107": { "compartment": "compartment_876", "id": "reaction_10625107", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10625104", "catalyst" ] ], "additional_components": [ "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "CHEBI:30805", "CHEBI:16196", "species_8934421", "species_2046044", "species_390435", "CHEBI:28875", "CHEBI:28866", "CHEBI:28822", "CHEBI:30813", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10624687": { "compartment": "compartment_70101", "id": "reaction_10624687", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10624684", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "species_83951", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10604139": { "compartment": "compartment_70101", "id": "reaction_10604139", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_179738" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10604136", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "species_83928", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:17256", "WBGene00017867" ] }, "reaction_10625065": { "compartment": "compartment_876", "id": "reaction_10625065", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10625062", "catalyst" ] ], "additional_components": [ "CHEBI:15544", "species_879535", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "species_879629", "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10604144": { "compartment": "compartment_70101", "id": "reaction_10604144", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83927", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "WBGene00009499" ] }, "reaction_10661501": { "compartment": "compartment_70101", "id": "reaction_10661501", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655821" ], "modifiers": [ [ "species_10661496", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00002278" ] }, "reaction_10661452": { "compartment": "compartment_70101", "id": "reaction_10661452", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10661444" ], "products": [ "species_29370", "species_10661449" ], "modifiers": [ [ "species_10606957", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10655808": { "compartment": "compartment_7660", "id": "reaction_10655808", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655802" ], "products": [ "species_10611220" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611223": { "compartment": "compartment_70101", "id": "reaction_10611223", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10655829": { "compartment": "compartment_70101", "id": "reaction_10655829", "reactome": "R-CEL-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655821", "species_29356" ], "products": [ "species_10611220", "species_10597908" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00001112" ] }, "reaction_10661506": { "compartment": "compartment_70101", "id": "reaction_10661506", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661503", "species_10597908" ], "products": [ "species_10657634" ], "modifiers": [ [ "species_10639898", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10661454": { "compartment": "compartment_13231", "id": "reaction_10661454", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661444" ], "products": [ "species_10661442" ], "modifiers": [ [ "species_10606957", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10636497": { "compartment": "compartment_70101", "id": "reaction_10636497", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10612150" ], "products": [ "species_10604443" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10611215": { "compartment": "compartment_876", "id": "reaction_10611215", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611003", "species_10610986" ], "products": [ "species_10611005" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10661299": { "compartment": "compartment_7660", "id": "reaction_10661299", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640221", "species_10661293" ], "products": [ "species_10661297" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773", "O17695", "WBGene00001834", "G5ECR1", "WBGene00023409", "G5EBZ4", "WBGene00002637", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "O61907", "WBGene00003025", "G5ED89", "WBGene00000938", "Q22516", "WBGene00000482", "G5EFF4", "WBGene00004773" ] }, "reaction_10657264": { "compartment": "compartment_70101", "id": "reaction_10657264", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10657260" ], "products": [ "species_10657262" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10636439": { "compartment": "compartment_70101", "id": "reaction_10636439", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612150", "species_179856" ], "products": [ "species_10636437" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10636520": { "compartment": "compartment_876", "id": "reaction_10636520", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610889", "species_10604443" ], "products": [ "species_10610891" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10657270": { "compartment": "compartment_70101", "id": "reaction_10657270", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10657262" ], "products": [ "species_29370", "species_10657267", "species_10657260" ], "modifiers": [ [ "species_10657262", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00000913", "WBGene00005078", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10655800": { "compartment": "compartment_70101", "id": "reaction_10655800", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655794" ], "products": [ "species_10655798" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10611007": { "compartment": "compartment_70101", "id": "reaction_10611007", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610986" ], "products": [ "species_29370", "species_10610889" ], "modifiers": [ [ "species_10611000", "catalyst" ], [ "species_10611005", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "Q9NA80", "WBGene00013261", "P91040", "WBGene00015697", "G5EFN2", "WBGene00009245", "Q95Q95", "WBGene00002583", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10657638": { "compartment": "compartment_70101", "id": "reaction_10657638", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657636" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10655818": { "compartment": "compartment_70101", "id": "reaction_10655818", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611220", "species_10597908" ], "products": [ "species_10655811" ], "modifiers": [ [ "species_10655815", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00006727", "WBGene00000913", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "G5ECY6", "WBGene00000500" ] }, "reaction_10636522": { "compartment": "compartment_70101", "id": "reaction_10636522", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617862", "species_179838" ], "products": [ "species_10610986" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10655805": { "compartment": "compartment_7660", "id": "reaction_10655805", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10655798" ], "products": [ "species_10655802", "species_10597874" ], "modifiers": [ [ "species_10648336", "catalyst" ], [ "species_10638301", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00006727", "WBGene00010406", "WBGene00003599" ] }, "reaction_10610912": { "compartment": "compartment_70101", "id": "reaction_10610912", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10610891" ], "products": [ "species_29370", "species_10610909", "species_10604443" ], "modifiers": [ [ "species_10610891", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "species_179838" ] }, "reaction_10661311": { "compartment": "compartment_7660", "id": "reaction_10661311", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661303", "species_10661305" ], "products": [ "species_10661309" ], "modifiers": [], "additional_components": [ "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22024", "WBGene00001207" ] }, "reaction_10657626": { "compartment": "compartment_70101", "id": "reaction_10657626", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611220" ], "products": [ "species_29370", "species_10657624" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10599349": { "compartment": "compartment_70101", "id": "reaction_10599349", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10599346", "catalyst" ] ], "additional_components": [ "Q9Y041", "WBGene00001843", "species_113531" ] }, "reaction_10599320": { "compartment": "compartment_70101", "id": "reaction_10599320", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10599317", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10599339": { "compartment": "compartment_70101", "id": "reaction_10599339", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10599336", "catalyst" ] ], "additional_components": [ "Q22633", "WBGene00001993", "Q18347", "WBGene00016294", "species_113531", "species_198836" ] }, "reaction_10599369": { "compartment": "compartment_70101", "id": "reaction_10599369", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10599366", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10599359": { "compartment": "compartment_70101", "id": "reaction_10599359", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10599356", "catalyst" ] ], "additional_components": [ "species_29450", "Q18938", "WBGene00001790" ] }, "reaction_10630983": { "compartment": "compartment_70616", "id": "reaction_10630983", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524079", "species_1524072" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10631012": { "compartment": "compartment_12045", "id": "reaction_10631012", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10631010": { "compartment": "compartment_12045", "id": "reaction_10631010", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524069", "species_1500578" ], "products": [ "species_76194", "species_1524081" ], "modifiers": [ [ "species_10603026", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10630999": { "compartment": "compartment_70616", "id": "reaction_10630999", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524083" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10630980", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10630972": { "compartment": "compartment_70616", "id": "reaction_10630972", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_29374", "species_1524072" ], "modifiers": [ [ "species_10630969", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10666115": { "compartment": "compartment_876", "id": "reaction_10666115", "reactome": "R-CEL-9712210", "name": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666095", "species_10666101", "species_9712200" ], "products": [ "species_10666113" ], "modifiers": [], "additional_components": [ "WBGene00001052", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "CHEBI:28837", "CHEBI:16424", "CHEBI:17580", "CHEBI:30772", "pubchem.compound:17356", "CHEBI:86192", "CHEBI:15409", "CHEBI:16731", "CHEBI:45571", "CHEBI:4917", "CHEBI:4918", "species_427486", "pubchem.compound:17072", "CHEBI:36740", "CHEBI:15400", "CHEBI:168721", "CHEBI:5331", "CHEBI:17362", "CHEBI:29452", "CHEBI:30065", "CHEBI:168585", "CHEBI:171895", "CHEBI:28591", "pubchem.compound:228987", "CHEBI:48408", "CHEBI:17447", "pubchem.compound:101330", "species_76328", "CHEBI:61727", "pubchem.compound:8144", "pubchem.compound:181287", "CHEBI:30776", "CHEBI:87362", "pubchem.compound:20499", "pubchem.compound:91604", "CHEBI:37894", "species_6807616", "CHEBI:15399", "pubchem.compound:92979", "pubchem.compound:106997", "CHEBI:28235", "CHEBI:18346", "CHEBI:76306", "CHEBI:34522", "pubchem.compound:61052", "CHEBI:46202", "CHEBI:18224", "CHEBI:30768", "CHEBI:28600", "CHEBI:28484", "CHEBI:30805", "CHEBI:34037", "CHEBI:28857", "CHEBI:67890", "pubchem.compound:64805", "CHEBI:167345", "CHEBI:28878", "CHEBI:89886", "species_29420", "P17343", "WBGene00001679", "CHEBI:4917", "G5ECT6", "WBGene00001682", "Q86ME6", "WBGene00001052", "CHEBI:167345", "V6CLB7", "WBGene00020997", "pubchem.compound:91604", "CHEBI:5331", "CHEBI:16731", "Q7KPV0", "WBGene00001745", "CHEBI:28484" ] }, "reaction_10661541": { "compartment": "compartment_70616", "id": "reaction_10661541", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606780" ], "products": [ "species_10661539" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10623825": { "compartment": "compartment_70101", "id": "reaction_10623825", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10623822", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10622101": { "compartment": "compartment_70101", "id": "reaction_10622101", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10622098", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10650271": { "compartment": "compartment_70101", "id": "reaction_10650271", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10650268", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10655667": { "compartment": "compartment_70101", "id": "reaction_10655667", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6803785" ], "products": [ "species_70106", "species_29370", "species_6803738" ], "modifiers": [ [ "species_10655664", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_6803743", "species_449703", "Q23196", "WBGene00021056" ] }, "reaction_10650281": { "compartment": "compartment_70101", "id": "reaction_10650281", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10641130": { "compartment": "compartment_12045", "id": "reaction_10641130", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10641127", "catalyst" ] ], "additional_components": [ "Q20118", "WBGene00009505", "Q5FC21", "WBGene00044025" ] }, "reaction_10655675": { "compartment": "compartment_70101", "id": "reaction_10655675", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803743", "species_29356" ], "products": [ "species_449701", "species_193473" ], "modifiers": [ [ "species_10655672", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10650263": { "compartment": "compartment_70101", "id": "reaction_10650263", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10650260", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10650289": { "compartment": "compartment_70101", "id": "reaction_10650289", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10650286", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10622051": { "compartment": "compartment_70101", "id": "reaction_10622051", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10622048", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10622373": { "compartment": "compartment_70101", "id": "reaction_10622373", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10622370", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10641138": { "compartment": "compartment_12045", "id": "reaction_10641138", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10622363": { "compartment": "compartment_70101", "id": "reaction_10622363", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10622360", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10622119": { "compartment": "compartment_70101", "id": "reaction_10622119", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10622116", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10620242": { "compartment": "compartment_17938", "id": "reaction_10620242", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10620239", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10650292": { "compartment": "compartment_70101", "id": "reaction_10650292", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10650278", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10648046": { "compartment": "compartment_7660", "id": "reaction_10648046", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648040" ], "products": [ "species_113582", "species_10648043" ], "modifiers": [ [ "species_10608272", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10625164": { "compartment": "compartment_5460", "id": "reaction_10625164", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625161", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10663595": { "compartment": "compartment_70101", "id": "reaction_10663595", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10642260", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10599553": { "compartment": "compartment_5460", "id": "reaction_10599553", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10599550", "catalyst" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596" ] }, "reaction_10598689": { "compartment": "compartment_70101", "id": "reaction_10598689", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29398" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10599144": { "compartment": "compartment_5460", "id": "reaction_10599144", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29362", "species_113587", "species_113529" ], "modifiers": [ [ "species_10599141", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10655838": { "compartment": "compartment_5460", "id": "reaction_10655838", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113557", "species_113529" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10655835", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10663592": { "compartment": "compartment_5460", "id": "reaction_10663592", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10663589", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10625174": { "compartment": "compartment_70616", "id": "reaction_10625174", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10625171", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10622718": { "compartment": "compartment_5462", "id": "reaction_10622718", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10622715", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10599198": { "compartment": "compartment_5460", "id": "reaction_10599198", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10599195", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10612583": { "compartment": "compartment_5460", "id": "reaction_10612583", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599550", "species_113593" ], "products": [ "species_113581", "species_10612567" ], "modifiers": [ [ "species_10612572", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_10612581", "inhibitor" ], [ "species_113557", "inhibitor" ] ], "additional_components": [ "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "species_8878387", "O17953", "WBGene00010794", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10599555": { "compartment": "compartment_5460", "id": "reaction_10599555", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10649888": { "compartment": "compartment_70101", "id": "reaction_10649888", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10649885", "catalyst" ] ], "additional_components": [ "species_216667", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10615570": { "compartment": "compartment_70101", "id": "reaction_10615570", "reactome": "R-CEL-373875", "name": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29708" ], "products": [ "species_373863", "species_351626" ], "modifiers": [ [ "species_10612981", "catalyst" ] ], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10599832": { "compartment": "compartment_5460", "id": "reaction_10599832", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10599829", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10622720": { "compartment": "compartment_5460", "id": "reaction_10622720", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10599121", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10622730": { "compartment": "compartment_5460", "id": "reaction_10622730", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113600", "species_29376", "species_113529" ], "modifiers": [ [ "species_10622727", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10599154": { "compartment": "compartment_5460", "id": "reaction_10599154", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113588" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10599151", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10625156": { "compartment": "compartment_5460", "id": "reaction_10625156", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10625153", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10663519": { "compartment": "compartment_5460", "id": "reaction_10663519", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612574", "species_9010792" ], "products": [ "species_10612581" ], "modifiers": [], "additional_components": [ "WBGene00022719", "species_9010792", "Q02332", "WBGene00022719" ] }, "reaction_10663554": { "compartment": "compartment_5460", "id": "reaction_10663554", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10663551", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_109496" ] }, "reaction_10599183": { "compartment": "compartment_5460", "id": "reaction_10599183", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10599180", "catalyst" ] ], "additional_components": [ "Q09508", "WBGene00015391", "O62215", "WBGene00009353", "P41956", "WBGene00003225", "Q09545", "WBGene00006433", "species_113596" ] }, "reaction_10599134": { "compartment": "compartment_5460", "id": "reaction_10599134", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10599131", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10599116": { "compartment": "compartment_5460", "id": "reaction_10599116", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599113", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q93353", "WBGene00007993", "Q20049", "WBGene00009440", "Q93714", "WBGene00009664", "species_266099" ] }, "reaction_10663526": { "compartment": "compartment_5460", "id": "reaction_10663526", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10663523", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10663568": { "compartment": "compartment_70101", "id": "reaction_10663568", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10663565", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_109496" ] }, "reaction_10599872": { "compartment": "compartment_70101", "id": "reaction_10599872", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29398" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10598686", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10629160": { "compartment": "compartment_70101", "id": "reaction_10629160", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353106", "species_29372" ], "products": [ "species_83951", "species_1237165" ], "modifiers": [ [ "species_10629157", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10629140": { "compartment": "compartment_70101", "id": "reaction_10629140", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10629137", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10630115": { "compartment": "compartment_70101", "id": "reaction_10630115", "reactome": "R-CEL-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10629127", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10629150": { "compartment": "compartment_70101", "id": "reaction_10629150", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10629147", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_109496" ] }, "reaction_10607469": { "compartment": "compartment_70616", "id": "reaction_10607469", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10607114", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29420", "species_29370", "species_113592", "species_29438" ] }, "reaction_10607123": { "compartment": "compartment_70616", "id": "reaction_10607123", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607114", "species_166213" ], "products": [ "species_10607116" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10607125": { "compartment": "compartment_70616", "id": "reaction_10607125", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607118" ], "products": [ "species_10607114", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10607121": { "compartment": "compartment_70616", "id": "reaction_10607121", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607116" ], "products": [ "species_10607118" ], "modifiers": [ [ "species_10607116", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10660441": { "compartment": "compartment_7660", "id": "reaction_10660441", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607861", "species_10658641" ], "products": [ "species_10660439" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "WBGene00004393", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393", "P45897", "WBGene00004858" ] }, "reaction_10660437": { "compartment": "compartment_7660", "id": "reaction_10660437", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660433", "species_10658641" ], "products": [ "species_10660435" ], "modifiers": [], "additional_components": [ "WBGene00022518", "WBGene00004393", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393" ] }, "reaction_10648407": { "compartment": "compartment_17951", "id": "reaction_10648407", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_5690520" ], "products": [ "species_193514", "species_5690539" ], "modifiers": [ [ "species_10648404", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10617868": { "compartment": "compartment_17947", "id": "reaction_10617868", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10617695": { "compartment": "compartment_17951", "id": "reaction_10617695", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_389596", "species_389573" ], "products": [ "species_389620", "species_389593", "species_389615" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617827": { "compartment": "compartment_17951", "id": "reaction_10617827", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10617824", "catalyst" ] ], "additional_components": [ "Q93839", "WBGene00010336", "species_113596" ] }, "reaction_10617818": { "compartment": "compartment_17951", "id": "reaction_10617818", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10656361": { "compartment": "compartment_17951", "id": "reaction_10656361", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617816": { "compartment": "compartment_17951", "id": "reaction_10617816", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10657324": { "compartment": "compartment_17947", "id": "reaction_10657324", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657320", "species_5690520" ], "products": [ "species_10657322" ], "modifiers": [], "additional_components": [ "Q20507", "WBGene00009818", "Q9XTZ5", "WBGene00007680", "Q20862", "WBGene00018949", "species_164991", "species_5690542", "Q20507", "WBGene00009818", "species_164991", "Q9XTZ5", "WBGene00007680", "species_5690542", "Q20862", "WBGene00018949" ] }, "reaction_10617708": { "compartment": "compartment_17951", "id": "reaction_10617708", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10617705", "catalyst" ] ], "additional_components": [ "species_113531", "O62515", "WBGene00014000" ] }, "reaction_10617674": { "compartment": "compartment_17951", "id": "reaction_10617674", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10617671", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10627078": { "compartment": "compartment_17951", "id": "reaction_10627078", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10627075", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10656358": { "compartment": "compartment_17951", "id": "reaction_10656358", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10656355", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10617698": { "compartment": "compartment_17951", "id": "reaction_10617698", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_6811612", "species_389573" ], "products": [ "species_389569", "species_389620", "species_389593" ], "modifiers": [ [ "species_10617692", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10617686": { "compartment": "compartment_17951", "id": "reaction_10617686", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10617683", "catalyst" ] ], "additional_components": [ "species_8878387", "Q17474", "WBGene00007143", "species_109496" ] }, "reaction_10650299": { "compartment": "compartment_17951", "id": "reaction_10650299", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10650296", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10656540": { "compartment": "compartment_17951", "id": "reaction_10656540", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10656537", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10613435": { "compartment": "compartment_70101", "id": "reaction_10613435", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331" ], "products": [ "species_10613333", "species_29420" ], "modifiers": [ [ "species_10613432", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "Q03206", "ced-10", "species_29438", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "species_29438", "G5ECK4", "WBGene00044989", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q21430", "WBGene00010776", "G5EF62", "WBGene00009337", "G5EFE1", "WBGene00006468", "Q9U364", "WBGene00002297", "Q965J0", "WBGene00019487", "Q9N5D3", "WBGene00004947", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10613439": { "compartment": "compartment_70101", "id": "reaction_10613439", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10613333", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10610461": { "compartment": "compartment_13231", "id": "reaction_10610461", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607331" ], "products": [ "species_10607264" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10620307": { "compartment": "compartment_70101", "id": "reaction_10620307", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620302" ], "products": [ "species_10620304", "species_29420" ], "modifiers": [ [ "species_10620302", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681" ] }, "reaction_10620381": { "compartment": "compartment_70101", "id": "reaction_10620381", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10620376" ], "products": [ "species_10620378", "species_29420" ], "modifiers": [ [ "species_10620376", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "CHEBI:15627", "P54406", "WBGene00001681", "Q19572", "WBGene00001674" ] }, "reaction_10641401": { "compartment": "compartment_7660", "id": "reaction_10641401", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641391" ], "products": [ "species_10641399", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00019884", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641432": { "compartment": "compartment_7660", "id": "reaction_10641432", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641415" ], "products": [ "species_10641430", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "P34534", "WBGene00019884", "P55853", "WBGene00004888", "G5ECQ8", "WBGene00022854", "Q23670", "WBGene00010785", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641275": { "compartment": "compartment_7660", "id": "reaction_10641275", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641264" ], "products": [ "species_10638173", "species_10641273" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00020915", "WBGene00006706", "O45012", "WBGene00020915", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638087": { "compartment": "compartment_7660", "id": "reaction_10638087", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638069", "species_10638074" ], "products": [ "species_10638084", "species_164121", "species_113541" ], "modifiers": [ [ "species_10638069", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10642632": { "compartment": "compartment_7660", "id": "reaction_10642632", "reactome": "R-CEL-5228508", "name": "RANBP2 SUMOylates PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10641447": { "compartment": "compartment_7660", "id": "reaction_10641447", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10641437" ], "products": [ "species_10641445", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006595", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638321": { "compartment": "compartment_7660", "id": "reaction_10638321", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638301" ], "products": [ "species_10638311", "species_10638173" ], "modifiers": [ [ "species_10638318", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003599", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "WBGene00006706", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10641361": { "compartment": "compartment_7660", "id": "reaction_10641361", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10598194" ], "products": [ "species_10638173", "species_10641359" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003955", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640956": { "compartment": "compartment_7660", "id": "reaction_10640956", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10638173" ], "products": [ "species_10640954", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640528": { "compartment": "compartment_7660", "id": "reaction_10640528", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10628901" ], "products": [ "species_10640526", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00000366", "P34545", "WBGene00000366", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641199": { "compartment": "compartment_13231", "id": "reaction_10641199", "reactome": "R-CEL-4551649", "name": "RANBP2 SUMOylates RANBP2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641186", "species_10638181" ], "products": [ "species_10641196", "species_10638173" ], "modifiers": [ [ "species_10602774", "catalyst" ] ], "additional_components": [ "WBGene00003795", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q86G90", "WBGene00003795", "P55853", "WBGene00004888", "WBGene00006706", "P91457", "WBGene00003793", "P91495", "WBGene00003798", "Q8T8M4", "WBGene00003792", "O01576", "WBGene00003797", "Q09601", "WBGene00003805", "O45933", "WBGene00003804", "Q95Y15", "WBGene00003794", "Q93454", "WBGene00003803", "Q7K6X4", "WBGene00003802", "Q19131", "WBGene00003791", "Q21436", "WBGene00003789", "Q17872", "WBGene00007493", "P34343", "WBGene00003801", "Q9BKT9", "WBGene00003799", "Q22078", "WBGene00003788", "Q8I4N3", "WBGene00007118", "Q86G90", "WBGene00003795", "Q9U3B9", "WBGene00003787", "A0A486WX27", "WBGene00019940", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10638341": { "compartment": "compartment_13231", "id": "reaction_10638341", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638328", "species_10638181" ], "products": [ "species_10638338", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10641300": { "compartment": "compartment_7660", "id": "reaction_10641300", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641290", "species_10638181" ], "products": [ "species_10641298", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640543": { "compartment": "compartment_7660", "id": "reaction_10640543", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640533", "species_10638181" ], "products": [ "species_10640541", "species_10638173" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10640987": { "compartment": "compartment_7660", "id": "reaction_10640987", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10640977" ], "products": [ "species_10638173", "species_10640985" ], "modifiers": [ [ "species_10638181", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001994", "WBGene00006706", "Q8MQ70", "WBGene00001994", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10638449": { "compartment": "compartment_7660", "id": "reaction_10638449", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638181", "species_10636923" ], "products": [ "species_10638413", "species_10638173" ], "modifiers": [ [ "species_10638446", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "P55853", "WBGene00004888", "WBGene00006706", "Q9XTV3", "WBGene00010409", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q18237", "WBGene00016151", "G5EG17", "WBGene00010056" ] }, "reaction_10641326": { "compartment": "compartment_70101", "id": "reaction_10641326", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641324" ], "products": [], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10640476": { "compartment": "compartment_70101", "id": "reaction_10640476", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640472", "species_10640470" ], "products": [ "species_10640474" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "species_29438" ] }, "reaction_10641973": { "compartment": "compartment_20592", "id": "reaction_10641973", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641961" ], "products": [ "species_10641971" ], "modifiers": [ [ "species_10641907", "catalyst" ] ], "additional_components": [ "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10641915": { "compartment": "compartment_876", "id": "reaction_10641915", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612022", "species_10641880" ], "products": [ "species_10641884" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238" ] }, "reaction_10641963": { "compartment": "compartment_876", "id": "reaction_10641963", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639064", "species_10641959" ], "products": [ "species_10641961" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b" ] }, "reaction_10641878": { "compartment": "compartment_876", "id": "reaction_10641878", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641874", "species_10639064" ], "products": [ "species_10641876" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238", "WBGene00000858", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "A0A0K3AWM6", "T23D8.1b", "Q9N532", "WBGene00003238" ] }, "reaction_10641891": { "compartment": "compartment_876", "id": "reaction_10641891", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10641884" ], "products": [ "species_29370", "species_10641886" ], "modifiers": [ [ "species_10641888", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10641913": { "compartment": "compartment_876", "id": "reaction_10641913", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10641907", "species_10641886" ], "products": [ "species_10641911" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238" ] }, "reaction_10640492": { "compartment": "compartment_876", "id": "reaction_10640492", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640488", "species_10640486" ], "products": [ "species_10640490" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10641957": { "compartment": "compartment_20592", "id": "reaction_10641957", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641911" ], "products": [ "species_10618761", "species_10641955" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "P90961", "WBGene00020246", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P90961", "WBGene00020246", "Q9N532", "WBGene00003238" ] }, "reaction_10641882": { "compartment": "compartment_876", "id": "reaction_10641882", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640846", "species_10639064" ], "products": [ "species_10641880" ], "modifiers": [], "additional_components": [ "WBGene00003238", "WBGene00000858", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238" ] }, "reaction_10660033": { "compartment": "compartment_876", "id": "reaction_10660033", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659990", "species_10657991", "species_10658032" ], "products": [ "species_10660031" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9XVQ7", "WBGene00008711", "Q9U2S4", "WBGene00000184", "Q23165", "WBGene00000166", "G5EDJ4", "WBGene00004928", "species_29438" ] }, "reaction_10643599": { "compartment": "compartment_876", "id": "reaction_10643599", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643587" ], "products": [ "species_10643597" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "G5ECQ2", "WBGene00000478", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "O01768", "WBGene00003072", "Q93372", "WBGene00010991", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10631246": { "compartment": "compartment_70101", "id": "reaction_10631246", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611990", "species_10611940" ], "products": [ "species_10611992" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "O62090", "WBGene00004202", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10612002": { "compartment": "compartment_876", "id": "reaction_10612002", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611992" ], "products": [ "species_29370", "species_10611999" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497", "O62090", "WBGene00004202", "Q22227", "WBGene00003241", "Q09595", "WBGene00010991", "A0A0K3AUI8", "C34F11.9e", "O01768", "WBGene00003072", "A0A0K3AWM6", "T23D8.1b", "Q18239", "WBGene00001102", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746", "Q3LRZ3", "WBGene00010497" ] }, "reaction_10603107": { "compartment": "compartment_7660", "id": "reaction_10603107", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602942" ], "products": [ "species_113582", "species_113550", "species_10602934" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10604747": { "compartment": "compartment_7660", "id": "reaction_10604747", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10603821" ], "products": [ "species_113541", "species_10603858" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664877": { "compartment": "compartment_7660", "id": "reaction_10664877", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602904" ], "products": [ "species_164121", "species_113541", "species_10602904" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602967" ], "products": [ "species_10603821", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602969": { "compartment": "compartment_7660", "id": "reaction_10602969", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602952" ], "products": [ "species_10602967", "species_10602053", "species_10602065", "species_113541", "species_10601970" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602954": { "compartment": "compartment_7660", "id": "reaction_10602954", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602904" ], "products": [ "species_10601975", "species_10602952", "species_113541" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "WBGene00006648", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10664879": { "compartment": "compartment_7660", "id": "reaction_10664879", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_10602067", "species_113541" ], "modifiers": [ [ "species_10601853", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441" ] }, "reaction_10602907": { "compartment": "compartment_7660", "id": "reaction_10602907", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10602067" ], "products": [ "species_113541", "species_10602904" ], "modifiers": [ [ "species_10599973", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10598407": { "compartment": "compartment_70101", "id": "reaction_10598407", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10598404", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10639536": { "compartment": "compartment_70101", "id": "reaction_10639536", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639531" ], "products": [ "species_110096", "species_10639533" ], "modifiers": [ [ "species_10639531", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640276": { "compartment": "compartment_70101", "id": "reaction_10640276", "reactome": "R-CEL-3780994", "name": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10640268" ], "products": [ "species_109402", "species_10640273" ], "modifiers": [ [ "species_10640268", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640292": { "compartment": "compartment_70101", "id": "reaction_10640292", "reactome": "R-CEL-3780997", "name": "PPP1R3C binds to glycogen:GYG2:GYS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639518", "species_10640266" ], "products": [ "species_10640268" ], "modifiers": [], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10665117": { "compartment": "compartment_70101", "id": "reaction_10665117", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10665114", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_109496" ] }, "reaction_10639526": { "compartment": "compartment_70101", "id": "reaction_10639526", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639508" ], "products": [ "species_10639518" ], "modifiers": [ [ "species_10639523", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10639511": { "compartment": "compartment_70101", "id": "reaction_10639511", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639506" ], "products": [ "species_110096", "species_10639508" ], "modifiers": [ [ "species_10639506", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10640297": { "compartment": "compartment_70101", "id": "reaction_10640297", "reactome": "R-CEL-3781011", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10640294" ], "products": [ "species_10640282", "species_29372" ], "modifiers": [ [ "species_10640294", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "Q966L7", "WBGene00019211", "H2KYT5", "WBGene00019211", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10639516": { "compartment": "compartment_70101", "id": "reaction_10639516", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10639513" ], "products": [ "species_110096", "species_10639506" ], "modifiers": [ [ "species_10639513", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_109496", "H2KYQ5", "WBGene00006863" ] }, "reaction_10648882": { "compartment": "compartment_70101", "id": "reaction_10648882", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_193132" ], "products": [ "species_70106", "species_29364", "species_193066" ], "modifiers": [ [ "species_10648879", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10666026": { "compartment": "compartment_70101", "id": "reaction_10666026", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10666023", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q23431", "WBGene00014241", "Q19605", "WBGene00009635" ] }, "reaction_10610423": { "compartment": "compartment_70101", "id": "reaction_10610423", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_193057" ], "products": [ "species_29366", "species_29460", "species_29356", "species_193132" ], "modifiers": [ [ "species_10610408", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q9U1R5", "WBGene00013585", "O17851", "WBGene00009226", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499", "Q9N4Q5", "WBGene00021167", "G5EGT6", "WBGene00010354", "Q27472", "WBGene00016147", "Q9N574", "WBGene00021200", "G5EC97", "WBGene00011830" ] }, "reaction_10661727": { "compartment": "compartment_70101", "id": "reaction_10661727", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10661724", "catalyst" ] ], "additional_components": [ "Q9N415", "WBGene00006513", "C7FZU5", "WBGene00077771" ] }, "reaction_10610421": { "compartment": "compartment_70101", "id": "reaction_10610421", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10610416", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10622873": { "compartment": "compartment_70101", "id": "reaction_10622873", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10622870", "catalyst" ] ], "additional_components": [ "Q20344", "WBGene00009635", "Q19605", "WBGene00009635" ] }, "reaction_10630301": { "compartment": "compartment_984", "id": "reaction_10630301", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630297", "species_1449707" ], "products": [ "species_10630299" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:27584", "CHEBI:17026", "CHEBI:16973", "CHEBI:17650", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "CHEBI:27584", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "CHEBI:17026", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "CHEBI:16973", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "CHEBI:17650" ] }, "reaction_10649574": { "compartment": "compartment_5460", "id": "reaction_10649574", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696835", "species_113563" ], "products": [ "species_113600", "species_5696848", "species_113529" ], "modifiers": [ [ "species_10649571", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610735": { "compartment": "compartment_70101", "id": "reaction_10610735", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_196095" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10666029": { "compartment": "compartment_70101", "id": "reaction_10666029", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10641135", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10659973": { "compartment": "compartment_70101", "id": "reaction_10659973", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10659970" ], "products": [ "species_29370", "species_10659935" ], "modifiers": [ [ "species_10659970", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10666213": { "compartment": "compartment_984", "id": "reaction_10666213", "reactome": "R-CEL-9734070", "name": "Anti-MET recombinant therapeutic antibodies bind MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618556", "species_9734118" ], "products": [ "species_10666211" ], "modifiers": [], "additional_components": [ "WBGene00008711", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C113802", "LigandDisplayForward?ligandId=7748", "Q9XVQ7", "WBGene00008711", "LigandDisplayForward?ligandId=8966", "ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C119619" ] }, "reaction_10659977": { "compartment": "compartment_70101", "id": "reaction_10659977", "reactome": "R-CEL-8875482", "name": "CBL recruits CIN85:endophilin to ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608683", "species_10659944" ], "products": [ "species_10659975" ], "modifiers": [], "additional_components": [ "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791" ] }, "reaction_10659981": { "compartment": "compartment_70101", "id": "reaction_10659981", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608658", "species_10659975" ], "products": [ "species_10659979" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "Q6A573", "WBGene00021549", "B1V8A0", "WBGene00006791", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224" ] }, "reaction_10659947": { "compartment": "compartment_70101", "id": "reaction_10659947", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10659935" ], "products": [ "species_10659944" ], "modifiers": [ [ "species_10659935", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10604651": { "compartment": "compartment_7660", "id": "reaction_10604651", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604647", "species_10604634" ], "products": [ "species_10604649" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00014066", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604660": { "compartment": "compartment_7660", "id": "reaction_10604660", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_10604649" ], "products": [ "species_10604657" ], "modifiers": [ [ "species_10604649", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10610473": { "compartment": "compartment_70101", "id": "reaction_10610473", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_29366", "species_193707" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610467": { "compartment": "compartment_17951", "id": "reaction_10610467", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610455": { "compartment": "compartment_17951", "id": "reaction_10610455", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10606370": { "compartment": "compartment_70101", "id": "reaction_10606370", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194069", "species_194073" ], "products": [ "species_76194", "species_193416" ], "modifiers": [ [ "species_10606367", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "species_192356", "species_193472", "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10659836": { "compartment": "compartment_70101", "id": "reaction_10659836", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_5357505", "species_10659832" ], "products": [ "species_10659834" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_176655", "species_5357505", "Q21130", "WBGene00010505" ] }, "reaction_10610485": { "compartment": "compartment_70101", "id": "reaction_10610485", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9617026", "species_29364" ], "products": [ "species_29366", "species_193829" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610446": { "compartment": "compartment_70101", "id": "reaction_10610446", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610547": { "compartment": "compartment_876", "id": "reaction_10610547", "reactome": "R-CEL-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10610544", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "WBGene00003407" ] }, "reaction_10610453": { "compartment": "compartment_17951", "id": "reaction_10610453", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193514", "species_193453" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:16525", "CHEBI:36274", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610260": { "compartment": "compartment_70101", "id": "reaction_10610260", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610277": { "compartment": "compartment_17951", "id": "reaction_10610277", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193514", "species_193404" ], "modifiers": [ [ "species_10610274", "catalyst" ] ], "additional_components": [ "CHEBI:15891", "species_159549", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10610465": { "compartment": "compartment_70101", "id": "reaction_10610465", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10666209": { "compartment": "compartment_70101", "id": "reaction_10666209", "reactome": "R-CEL-9733973", "name": "Bile salts bind FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643137", "species_194156" ], "products": [ "species_10666205" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274" ] }, "reaction_10610287": { "compartment": "compartment_17951", "id": "reaction_10610287", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10666207": { "compartment": "compartment_70101", "id": "reaction_10666207", "reactome": "R-CEL-9733969", "name": "Bile salts dissociate from FABP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666205" ], "products": [ "species_10643137", "species_194156" ], "modifiers": [], "additional_components": [ "CHEBI:17687", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "CHEBI:16755", "O02324", "WBGene00002260", "species_193451", "CHEBI:16525", "CHEBI:28865", "Q965W1", "WBGene00021486", "CHEBI:36274", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274" ] }, "reaction_10610477": { "compartment": "compartment_17951", "id": "reaction_10610477", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610489": { "compartment": "compartment_70101", "id": "reaction_10610489", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610433": { "compartment": "compartment_17951", "id": "reaction_10610433", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_141343" ], "products": [ "species_193514", "species_193451" ], "modifiers": [ [ "species_10610430", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10610483": { "compartment": "compartment_70101", "id": "reaction_10610483", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193829" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610463": { "compartment": "compartment_70101", "id": "reaction_10610463", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610324": { "compartment": "compartment_17951", "id": "reaction_10610324", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10659235": { "compartment": "compartment_70101", "id": "reaction_10659235", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_1806234", "species_8868393" ], "modifiers": [ [ "species_10659232", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10606345": { "compartment": "compartment_70101", "id": "reaction_10606345", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_194096" ], "products": [ "species_111294", "species_76577", "species_29356", "species_194073" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "CHEBI:16755", "species_193451", "species_192356", "species_193472", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10659112": { "compartment": "compartment_70101", "id": "reaction_10659112", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10659109", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10610262": { "compartment": "compartment_70101", "id": "reaction_10610262", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610425": { "compartment": "compartment_17951", "id": "reaction_10610425", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10610321", "catalyst" ] ], "additional_components": [ "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "species_113596", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10610475": { "compartment": "compartment_70101", "id": "reaction_10610475", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610457": { "compartment": "compartment_17951", "id": "reaction_10610457", "reactome": "R-CEL-193533", "name": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_193403" ], "products": [ "species_192314", "species_193472" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610528": { "compartment": "compartment_876", "id": "reaction_10610528", "reactome": "R-CEL-194121", "name": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610525", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610469": { "compartment": "compartment_70101", "id": "reaction_10610469", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193778" ], "products": [ "species_111294", "species_76577", "species_193739", "species_29356" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610258": { "compartment": "compartment_17951", "id": "reaction_10610258", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610459": { "compartment": "compartment_17951", "id": "reaction_10610459", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610451": { "compartment": "compartment_17951", "id": "reaction_10610451", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10610284", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10610479": { "compartment": "compartment_70101", "id": "reaction_10610479", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_193762", "species_113592" ], "products": [ "species_111294", "species_193741", "species_76577", "species_29356" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10610448": { "compartment": "compartment_17951", "id": "reaction_10610448", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10610255", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10610233": { "compartment": "compartment_70101", "id": "reaction_10610233", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192136" ], "products": [ "species_29366", "species_191980" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610471": { "compartment": "compartment_70101", "id": "reaction_10610471", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193724" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610332": { "compartment": "compartment_17951", "id": "reaction_10610332", "reactome": "R-CEL-192341", "name": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_192339" ], "products": [ "species_192356", "species_192314" ], "modifiers": [ [ "species_10610329", "catalyst" ] ], "additional_components": [ "WBGene00013284" ] }, "reaction_10610487": { "compartment": "compartment_70101", "id": "reaction_10610487", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10610230", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610481": { "compartment": "compartment_70101", "id": "reaction_10610481", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193707" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610552": { "compartment": "compartment_876", "id": "reaction_10610552", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_192483" ], "products": [ "species_83910", "species_194156" ], "modifiers": [ [ "species_10610549", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "species_193451", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "WBGene00044650" ] }, "reaction_10610264": { "compartment": "compartment_70101", "id": "reaction_10610264", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191980" ], "products": [ "species_29366", "species_192030" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610442": { "compartment": "compartment_70101", "id": "reaction_10610442", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_192013", "species_113592" ], "products": [ "species_192096", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610439", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10643250": { "compartment": "compartment_7660", "id": "reaction_10643250", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10616320" ], "products": [ "species_10643248" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "Q9XYB7", "WBGene00003607", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908", "Q9XYB7", "WBGene00003607", "species_176655", "CHEBI:16755", "species_5357505", "Q94407", "WBGene00003638", "G5EFF5", "WBGene00000908" ] }, "reaction_10610198": { "compartment": "compartment_70101", "id": "reaction_10610198", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10610195", "catalyst" ] ], "additional_components": [ "species_113531", "Q20027", "WBGene00018036" ] }, "reaction_10610250": { "compartment": "compartment_70101", "id": "reaction_10610250", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10610444": { "compartment": "compartment_70101", "id": "reaction_10610444", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_193505" ], "products": [ "species_193457", "species_111294", "species_76577" ], "modifiers": [ [ "species_10606342", "catalyst" ] ], "additional_components": [ "Q19878", "WBGene00009218", "Q18916", "WBGene00017012" ] }, "reaction_10614222": { "compartment": "compartment_13231", "id": "reaction_10614222", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605337" ], "products": [ "species_10614220" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10614879": { "compartment": "compartment_7660", "id": "reaction_10614879", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614875", "species_29428" ], "products": [ "species_10614877" ], "modifiers": [], "additional_components": [ "Q94234", "WBGene00001975", "Q09390", "WBGene00001972", "Q94234", "WBGene00001975", "Q09390", "WBGene00001972" ] }, "reaction_10665078": { "compartment": "compartment_876", "id": "reaction_10665078", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608583", "species_10665063" ], "products": [ "species_10665076" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838" ] }, "reaction_10649463": { "compartment": "compartment_70101", "id": "reaction_10649463", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10649460", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10665073": { "compartment": "compartment_7660", "id": "reaction_10665073", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665069" ], "products": [ "species_10665071" ], "modifiers": [ [ "species_10607578", "catalyst" ], [ "species_10611037", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "WBGene00002078", "P39745", "WBGene00003401" ] }, "reaction_10661072": { "compartment": "compartment_7660", "id": "reaction_10661072", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10661060" ], "products": [ "species_10661062" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10664151": { "compartment": "compartment_7660", "id": "reaction_10664151", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664147", "species_10664133" ], "products": [ "species_10664149" ], "modifiers": [], "additional_components": [ "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q21187", "WBGene00001441", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9TYU5", "WBGene00007029", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q9NEX2", "WBGene00013736", "P34545", "WBGene00000366", "O44625", "WBGene00004136", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "CHEBI:142773", "Q9N3S7", "WBGene00021636", "Q21187", "WBGene00001441", "Q9TYU5", "WBGene00007029", "species_193132", "P32085", "WBGene00006542", "CHEBI:27974", "species_193066" ] }, "reaction_10611449": { "compartment": "compartment_70101", "id": "reaction_10611449", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_76194", "species_201034" ], "modifiers": [ [ "species_10611446", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9U2F2", "WBGene00012907", "Q23066", "WBGene00020911", "O16992", "WBGene00021002", "G5EG54", "WBGene00008629", "Q9N3N3", "WBGene00021703", "O44619", "WBGene00019644" ] }, "reaction_10643512": { "compartment": "compartment_70101", "id": "reaction_10643512", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643509", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "O01758", "WBGene00000966", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "O16881", "WBGene00000979", "Q19843", "WBGene00000992", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10663480": { "compartment": "compartment_7660", "id": "reaction_10663480", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649873", "species_10663476", "species_10663464" ], "products": [ "species_10663462", "species_10628319", "species_10663478" ], "modifiers": [], "additional_components": [ "G5EF71", "WBGene00003180", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "Q17381", "WBGene00004013", "Q21187", "WBGene00001441", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "P45972", "WBGene00011639", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "WBGene00011639", "WBGene00001834", "Q17381", "WBGene00004013", "G5EF71", "WBGene00003180", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "B7WN96", "WBGene00001251", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q9XUW7", "WBGene00001311", "P04255", "WBGene00001885", "P28515", "WBGene00001249", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q21187", "WBGene00001441", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10644649": { "compartment": "compartment_70101", "id": "reaction_10644649", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10665002": { "compartment": "compartment_7660", "id": "reaction_10665002", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611173" ], "products": [ "species_113582", "species_10611187" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10644961": { "compartment": "compartment_70101", "id": "reaction_10644961", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643550" ], "products": [ "species_10643552" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665085": { "compartment": "compartment_876", "id": "reaction_10665085", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665076" ], "products": [ "species_10665080" ], "modifiers": [], "additional_components": [ "species_29420", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "P22981", "WBGene00002335", "species_179838", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10665066": { "compartment": "compartment_876", "id": "reaction_10665066", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665058", "species_113592" ], "products": [ "species_29370", "species_10665063" ], "modifiers": [ [ "species_10665058", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "Q19266", "WBGene00004034", "species_179838" ] }, "reaction_10666083": { "compartment": "compartment_7660", "id": "reaction_10666083", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661066", "species_1254400" ], "products": [ "species_10661068" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "Q9NES8", "WBGene00012665", "species_113592", "Q23280", "WBGene00022599", "Q09637", "WBGene00000885", "species_1254400" ] }, "reaction_10612137": { "compartment": "compartment_70101", "id": "reaction_10612137", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10612134", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10645853": { "compartment": "compartment_70101", "id": "reaction_10645853", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643186" ], "products": [ "species_10645851" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643570": { "compartment": "compartment_70101", "id": "reaction_10643570", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_30927" ], "products": [ "species_70106", "species_73473", "species_32737" ], "modifiers": [ [ "species_10643567", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20840", "WBGene00018885", "Q20012", "WBGene00000983" ] }, "reaction_10643188": { "compartment": "compartment_70101", "id": "reaction_10643188", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10643184" ], "products": [ "species_10643186" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10643631": { "compartment": "compartment_70101", "id": "reaction_10643631", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10643628", "catalyst" ] ], "additional_components": [ "Q22392", "WBGene00000982", "G5EET7", "WBGene00011940", "G5EGA6", "WBGene00010063", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q1XFZ3", "WBGene00000980" ] }, "reaction_10663581": { "compartment": "compartment_7660", "id": "reaction_10663581", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663576", "species_29358" ], "products": [ "species_113582", "species_10663578" ], "modifiers": [ [ "species_10663576", "catalyst" ] ], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "species_1254400", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10643557": { "compartment": "compartment_70101", "id": "reaction_10643557", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10643554", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10644959": { "compartment": "compartment_70101", "id": "reaction_10644959", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602448", "species_5334816" ], "products": [ "species_10644957" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665037": { "compartment": "compartment_876", "id": "reaction_10665037", "reactome": "R-CEL-9625482", "name": "PTK2 binds activated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901", "species_10608528" ], "products": [ "species_10665035" ], "modifiers": [], "additional_components": [ "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10665042": { "compartment": "compartment_876", "id": "reaction_10665042", "reactome": "R-CEL-9625487", "name": "PTK2 autophosphorylates downstream of EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10665035" ], "products": [ "species_29370", "species_10665039" ], "modifiers": [ [ "species_10665035", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q95YD4", "WBGene00002213", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10643533": { "compartment": "compartment_70101", "id": "reaction_10643533", "reactome": "R-CEL-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10643530", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10645837": { "compartment": "compartment_70101", "id": "reaction_10645837", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644957" ], "products": [ "species_10645835" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10665044": { "compartment": "compartment_876", "id": "reaction_10665044", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10645083": { "compartment": "compartment_70616", "id": "reaction_10645083", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10645080", "catalyst" ] ], "additional_components": [ "WBGene00000987" ] }, "reaction_10665082": { "compartment": "compartment_7660", "id": "reaction_10665082", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607884" ], "products": [ "species_10611037" ], "modifiers": [ [ "species_10665080", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "P22981", "WBGene00002335", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "species_29438" ] }, "reaction_10633165": { "compartment": "compartment_20699", "id": "reaction_10633165", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633162", "catalyst" ] ], "additional_components": [ "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633271": { "compartment": "compartment_20699", "id": "reaction_10633271", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633120": { "compartment": "compartment_20699", "id": "reaction_10633120", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10633117", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10633297": { "compartment": "compartment_20699", "id": "reaction_10633297", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633160", "species_10633295" ], "products": [ "species_10633162" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183", "WBGene00018076", "Q20077", "WBGene00018076", "Q94231", "WBGene00000190", "Q09654", "WBGene00000180", "Q10943", "WBGene00000182", "CHEBI:15996", "G5EFK4", "WBGene00000183" ] }, "reaction_10633321": { "compartment": "compartment_20699", "id": "reaction_10633321", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10633318", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10633208": { "compartment": "compartment_20699", "id": "reaction_10633208", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633279": { "compartment": "compartment_20699", "id": "reaction_10633279", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10633268", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10633176": { "compartment": "compartment_20699", "id": "reaction_10633176", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10633173", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10666348": { "compartment": "compartment_7660", "id": "reaction_10666348", "reactome": "R-CEL-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597804", "species_10597787" ], "products": [ "species_10597806" ], "modifiers": [], "additional_components": [ "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158", "WBGene00003154", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10597692": { "compartment": "compartment_7660", "id": "reaction_10597692", "reactome": "R-CEL-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597686", "species_10597678" ], "products": [ "species_10597690" ], "modifiers": [], "additional_components": [ "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882", "Q9XX17", "WBGene00012650", "Q9XX17", "WBGene00012650", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q21037", "WBGene00003882" ] }, "reaction_10666265": { "compartment": "compartment_7660", "id": "reaction_10666265", "reactome": "R-CEL-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597818", "species_10597806" ], "products": [ "species_10597820" ], "modifiers": [], "additional_components": [ "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "Q9XXI9", "WBGene00003154", "P34647", "WBGene00003158" ] }, "reaction_10666223": { "compartment": "compartment_70101", "id": "reaction_10666223", "reactome": "R-CEL-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666221" ], "products": [ "species_10597674" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10666346": { "compartment": "compartment_7660", "id": "reaction_10666346", "reactome": "R-CEL-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597797", "species_10597792", "species_10597802" ], "products": [ "species_10597804" ], "modifiers": [], "additional_components": [ "WBGene00003158", "WBGene00003156", "WBGene00003159", "Q95XQ8", "WBGene00003156", "O16297", "WBGene00003159", "P34647", "WBGene00003158" ] }, "reaction_10666344": { "compartment": "compartment_7660", "id": "reaction_10666344", "reactome": "R-CEL-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597811", "species_10597816" ], "products": [ "species_10597818" ], "modifiers": [], "additional_components": [ "WBGene00003155", "WBGene00003157", "Q21902", "WBGene00003157", "Q9XVR7", "WBGene00003155" ] }, "reaction_10666263": { "compartment": "compartment_7660", "id": "reaction_10666263", "reactome": "R-CEL-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666259", "species_10597674" ], "products": [ "species_10666261" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00012650", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q9XX17", "WBGene00012650", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10612074": { "compartment": "compartment_70101", "id": "reaction_10612074", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612026" ], "products": [ "species_29370", "species_10612049" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10640242": { "compartment": "compartment_70101", "id": "reaction_10640242", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10612049" ], "products": [ "species_29370", "species_10611988" ], "modifiers": [ [ "species_10640239", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00002203" ] }, "reaction_10640245": { "compartment": "compartment_70101", "id": "reaction_10640245", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10640232", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10640234": { "compartment": "compartment_70101", "id": "reaction_10640234", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633032", "species_10611988" ], "products": [ "species_10640232" ], "modifiers": [], "additional_components": [ "WBGene00004087", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "O01759", "WBGene00004087" ] }, "reaction_10605873": { "compartment": "compartment_7660", "id": "reaction_10605873", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605860" ], "products": [ "species_113582", "species_10605864" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10637119": { "compartment": "compartment_70101", "id": "reaction_10637119", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10637115" ], "products": [ "species_29370", "species_10637105" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10665030": { "compartment": "compartment_70101", "id": "reaction_10665030", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10665018" ], "products": [ "species_10665028" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10664962": { "compartment": "compartment_70101", "id": "reaction_10664962", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602699", "species_10664958" ], "products": [ "species_10664960" ], "modifiers": [], "additional_components": [ "P91457", "WBGene00003793", "Q17602", "WBGene00003800", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796", "P91457", "WBGene00003793", "Q19131", "WBGene00003791", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "P34343", "WBGene00003801", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q17602", "WBGene00003800", "Q9N4A7", "WBGene00003806", "G5EEH9", "WBGene00003796" ] }, "reaction_10636865": { "compartment": "compartment_1598585", "id": "reaction_10636865", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636850" ], "products": [ "species_29370", "species_10636862" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10665723": { "compartment": "compartment_13231", "id": "reaction_10665723", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665704", "species_10665708" ], "products": [ "species_10665710" ], "modifiers": [], "additional_components": [ "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636955": { "compartment": "compartment_7660", "id": "reaction_10636955", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636925", "species_10636923", "species_10636929" ], "products": [ "species_10636931" ], "modifiers": [], "additional_components": [ "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "WBGene00019953", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665026": { "compartment": "compartment_1598585", "id": "reaction_10665026", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10649915" ], "products": [ "species_10665018", "species_29420" ], "modifiers": [ [ "species_10665023", "catalyst" ] ], "additional_components": [ "species_29420", "O17915", "WBGene00004302", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10665033": { "compartment": "compartment_70101", "id": "reaction_10665033", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665028", "species_29356" ], "products": [ "species_10649915", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10638338", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "species_29420", "O17915", "WBGene00004302", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10638249": { "compartment": "compartment_70101", "id": "reaction_10638249", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638243", "species_10638238" ], "products": [ "species_10638247" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "Q19848", "WBGene00017895", "H2KZB2", "WBGene00021945" ] }, "reaction_10665721": { "compartment": "compartment_70101", "id": "reaction_10665721", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665712", "species_10665717" ], "products": [ "species_10665719" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00021334", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q9BL83", "WBGene00021334", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636984": { "compartment": "compartment_1598585", "id": "reaction_10636984", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10636976", "species_10636931" ], "products": [ "species_10636982" ], "modifiers": [], "additional_components": [ "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q95XZ5", "WBGene00004166", "Q19325", "WBGene00004737", "O17581", "WBGene00003136", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352" ] }, "reaction_10665725": { "compartment": "compartment_70101", "id": "reaction_10665725", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665710", "species_10665699" ], "products": [ "species_10665712" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578", "WBGene00016045", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10665728": { "compartment": "compartment_70101", "id": "reaction_10665728", "reactome": "R-CEL-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_10616987" ], "modifiers": [ [ "species_10665712", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "G5ECX8", "WBGene00010736", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q8MNV0", "WBGene00016045", "Q9XTB5", "WBGene00002275", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2M8", "WBGene00012578" ] }, "reaction_10636891": { "compartment": "compartment_70101", "id": "reaction_10636891", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636880" ], "products": [ "species_10636888" ], "modifiers": [ [ "species_10636880", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10636964": { "compartment": "compartment_1598585", "id": "reaction_10636964", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10636961" ], "products": [ "species_29370", "species_10636850" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "H2L0H5", "WBGene00019953", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10637117": { "compartment": "compartment_70101", "id": "reaction_10637117", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637105", "species_29356" ], "products": [ "species_10637115", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "G5EFJ4", "WBGene00009254", "Q9U2M1", "WBGene00001087" ] }, "reaction_10605887": { "compartment": "compartment_7660", "id": "reaction_10605887", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605878", "species_113592" ], "products": [ "species_29370", "species_10605882" ], "modifiers": [ [ "species_10605884", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10665692": { "compartment": "compartment_70101", "id": "reaction_10665692", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625894", "species_10638238" ], "products": [ "species_10665690" ], "modifiers": [], "additional_components": [ "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00021945", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "H2KZB2", "WBGene00021945" ] }, "reaction_10662392": { "compartment": "compartment_17957", "id": "reaction_10662392", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662092", "species_8931885" ], "products": [ "species_10662385", "species_8931884" ], "modifiers": [ [ "species_10662092", "catalyst" ], [ "species_10662390", "catalyst" ] ], "additional_components": [ "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q20684", "WBGene00002265", "G5EC10", "WBGene00002272", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "H2L2L3", "WBGene00013326", "P92172", "WBGene00000903", "Q21265", "WBGene00019478", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q9XWD6", "WBGene00000415", "O16273", "WBGene00006570", "G5EBV4", "WBGene00002273", "G5EEL5", "WBGene00000936", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "Q11186", "WBGene00015484", "Q20549", "WBGene00235368", "Q9BL47", "WBGene00022175", "G5ECV3", "WBGene00007284", "G5EE40", "WBGene00005642", "O01330", "WBGene00235368", "C4RVF6", "WBGene00235368", "H2KZY5", "WBGene00018533", "G5EFI4", "WBGene00002268", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "O01331", "WBGene00235368", "Q09277", "WBGene00235368", "Q94215", "WBGene00002274", "G5EC87", "WBGene00014249", "Q9GZD9", "WBGene00235368", "Q9N3E0", "WBGene00001046", "A9Z1L1", "WBGene00005648", "O01329", "WBGene00235368", "O45520", "WBGene00009708", "Q18813", "WBGene00235368", "Q18530", "WBGene00003056", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "U4PM93", "WBGene00235368", "Q21267", "WBGene00019476", "Q9GZD8", "WBGene00235368", "Q23046", "WBGene00020806", "Q09581", "WBGene00002266", "Q17770", "WBGene00003963", "Q9XTW2", "WBGene00010356", "K8ERT0", "WBGene00235368", "Q9GZE0", "WBGene00235368", "Q9XVQ1", "WBGene00009708", "F5GU58", "WBGene00235368", "P36573", "WBGene00002264", "Q11067", "WBGene00015168", "Q20256", "WBGene00235368", "G5EFD9", "WBGene00006324", "Q8WQF8", "WBGene00017220", "Q9XU98", "WBGene00009304", "Q10651", "WBGene00000149", "G5EBH7", "WBGene00019760", "Q8MQ51", "WBGene00009674", "O44565", "WBGene00002247", "G5ECY2", "WBGene00005644", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "Q18096", "WBGene00007687", "Q8WQF7", "WBGene00017220", "Q09610", "WBGene00002271", "Q22235", "WBGene00011480", "G5EGU4", "WBGene00001687", "Q9U2I7", "WBGene00004165", "Q9N384", "WBGene00002269", "Q7YTU0", "WBGene00013969", "Q09605", "WBGene00002270", "Q18625", "WBGene00002267", "Q11184", "WBGene00002881", "Q9XTW2", "WBGene00010356" ] }, "reaction_10616363": { "compartment": "compartment_17938", "id": "reaction_10616363", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616360", "species_113592" ], "products": [ "species_29370", "species_10606983" ], "modifiers": [ [ "species_10612120", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10662470": { "compartment": "compartment_70101", "id": "reaction_10662470", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10606953", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607018": { "compartment": "compartment_17938", "id": "reaction_10607018", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606964", "species_113592" ], "products": [ "species_29370", "species_10606968" ], "modifiers": [ [ "species_10606957", "catalyst" ], [ "species_10606997", "catalyst" ], [ "species_10606979", "inhibitor" ], [ "species_10607016", "inhibitor" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10617104": { "compartment": "compartment_70101", "id": "reaction_10617104", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611523" ], "products": [ "species_10611508", "species_29372" ], "modifiers": [ [ "species_10617101", "catalyst" ] ], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "G5EEM6", "WBGene00006524", "Q19775", "WBGene00006460" ] }, "reaction_10607031": { "compartment": "compartment_70101", "id": "reaction_10607031", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601072" ], "products": [ "species_29370", "species_10607028" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "WBGene00012929" ] }, "reaction_10606878": { "compartment": "compartment_17938", "id": "reaction_10606878", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606874", "species_29438" ], "products": [ "species_10606876", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10665764": { "compartment": "compartment_70101", "id": "reaction_10665764", "reactome": "R-CEL-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10607014" ], "products": [ "species_10607016" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427", "species_9678687", "O45418", "WBGene00001431", "Q8I4E5", "WBGene00001433", "Q9U2Q8", "WBGene00001427" ] }, "reaction_10646908": { "compartment": "compartment_17938", "id": "reaction_10646908", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606997" ], "products": [ "species_29370", "species_10646905" ], "modifiers": [ [ "species_10606997", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607048": { "compartment": "compartment_70101", "id": "reaction_10607048", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601231" ], "products": [ "species_29370", "species_10607046" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "WBGene00012929" ] }, "reaction_10646165": { "compartment": "compartment_70101", "id": "reaction_10646165", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606947", "species_10606934" ], "products": [ "species_10606949" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414", "species_29420", "G5EGB3", "WBGene00012497", "species_29438", "Q22743", "WBGene00006414" ] }, "reaction_10646899": { "compartment": "compartment_17938", "id": "reaction_10646899", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606983", "species_10606995" ], "products": [ "species_10606997" ], "modifiers": [], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "P41932", "WBGene00003920", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "species_29420", "Q20655", "WBGene00001502", "P91040", "WBGene00015697", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10606959": { "compartment": "compartment_70101", "id": "reaction_10606959", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10606955" ], "products": [ "species_10606957" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10607041": { "compartment": "compartment_70101", "id": "reaction_10607041", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607036" ], "products": [ "species_29370", "species_10607039" ], "modifiers": [ [ "species_10606968", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "WBGene00012929" ] }, "reaction_10646167": { "compartment": "compartment_17938", "id": "reaction_10646167", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606953", "species_10606895" ], "products": [ "species_10606955" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "species_29420", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "species_29438", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414" ] }, "reaction_10622209": { "compartment": "compartment_876", "id": "reaction_10622209", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606957" ], "products": [ "species_29370", "species_10606979" ], "modifiers": [ [ "species_10617093", "catalyst" ] ], "additional_components": [ "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "species_29420", "P34443", "WBGene00010038", "Q68TI8", "WBGene00000911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "P91040", "WBGene00015697", "Q8WQG5", "WBGene00007390", "species_29438", "Q19425", "WBGene00008774", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10617095": { "compartment": "compartment_70101", "id": "reaction_10617095", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_10611523" ], "products": [ "species_10617093" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "P45894", "WBGene00019801", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605906", "species_10605890" ], "products": [ "species_10605908" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00004428", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q9U302", "WBGene00003902", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "D0G912", "WBGene00194816", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10605914": { "compartment": "compartment_70101", "id": "reaction_10605914", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601533" ], "products": [ "species_10605912", "species_10601331" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "WBGene00004428" ] }, "reaction_10665593": { "compartment": "compartment_876", "id": "reaction_10665593", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10665590", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EGA7", "WBGene00004311", "Q22875", "WBGene00004929", "species_29438", "Q27497", "WBGene00001747", "P48727", "WBGene00001748" ] }, "reaction_10665461": { "compartment": "compartment_12045", "id": "reaction_10665461", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346" ], "products": [ "species_10607835" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10635276": { "compartment": "compartment_70101", "id": "reaction_10635276", "reactome": "R-CEL-2028735", "name": "AMOT proteins bind WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635239" ], "products": [ "species_10635274" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10647126": { "compartment": "compartment_876", "id": "reaction_10647126", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10647122" ], "products": [ "species_10647124" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "WBGene00017144", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10640339": { "compartment": "compartment_383505", "id": "reaction_10640339", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640317" ], "products": [ "species_10640337" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10658530": { "compartment": "compartment_876", "id": "reaction_10658530", "reactome": "R-CEL-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658515", "species_29356" ], "products": [ "species_10658527", "species_29372" ], "modifiers": [ [ "species_10658515", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10640341": { "compartment": "compartment_876", "id": "reaction_10640341", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10640317" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10609406": { "compartment": "compartment_70101", "id": "reaction_10609406", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10609384", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617376": { "compartment": "compartment_984", "id": "reaction_10617376", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617364" ], "products": [ "species_10617374" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10665529": { "compartment": "compartment_17906", "id": "reaction_10665529", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665523", "species_10625038" ], "products": [ "species_10665527" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P22981", "WBGene00002335", "P41958", "WBGene00000423" ] }, "reaction_10665450": { "compartment": "compartment_12045", "id": "reaction_10665450", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665357" ], "products": [ "species_10665341" ], "modifiers": [ [ "species_10665447", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10646527": { "compartment": "compartment_7660", "id": "reaction_10646527", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646523", "species_10639320" ], "products": [ "species_10646525" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10665525": { "compartment": "compartment_17906", "id": "reaction_10665525", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665507" ], "products": [ "species_10665523" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10647016": { "compartment": "compartment_876", "id": "reaction_10647016", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10647013", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "W6RS10", "WBGene00019902", "Q21408", "WBGene00004951", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "C6KRM7", "WBGene00004372", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "E0AHA7", "WBGene00006803", "species_114519", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XWK4", "WBGene00013202", "G5EDB9", "WBGene00004254", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "E6N0V1", "WBGene00018819", "Q19770", "WBGene00009100", "O18008", "WBGene00021745", "G5EFW3", "WBGene00004855" ] }, "reaction_10611938": { "compartment": "compartment_70101", "id": "reaction_10611938", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610707" ], "products": [ "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10617354": { "compartment": "compartment_20699", "id": "reaction_10617354", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617336" ], "products": [ "species_10617352" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10635617": { "compartment": "compartment_70101", "id": "reaction_10635617", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635613" ], "products": [ "species_10635615" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10642546": { "compartment": "compartment_70101", "id": "reaction_10642546", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642538", "species_113592" ], "products": [ "species_29370", "species_10642543", "species_10620766" ], "modifiers": [ [ "species_10609574", "catalyst" ] ], "additional_components": [ "species_113592", "A0A1I6CMC9", "WBGene00021943", "P10984", "WBGene00000064", "WBGene00021943", "species_113592", "P10984", "WBGene00000064", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10609380": { "compartment": "compartment_876", "id": "reaction_10609380", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609278", "species_10609364" ], "products": [ "species_10609374" ], "modifiers": [ [ "species_10609376", "inhibitor" ], [ "species_10609378", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=9172", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665504": { "compartment": "compartment_876", "id": "reaction_10665504", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647018", "species_9657579" ], "products": [ "species_10647108" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q20655", "WBGene00001502", "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "P22981", "WBGene00002335", "LigandDisplayForward?ligandId=9977", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10611822": { "compartment": "compartment_876", "id": "reaction_10611822", "reactome": "R-CEL-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611819" ], "products": [ "species_29370", "species_10611801" ], "modifiers": [ [ "species_10611819", "catalyst" ] ], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856" ] }, "reaction_10665991": { "compartment": "compartment_70101", "id": "reaction_10665991", "reactome": "R-CEL-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665979" ], "products": [ "species_10665989" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10643019": { "compartment": "compartment_171062", "id": "reaction_10643019", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602372", "species_10602367" ], "products": [ "species_10602374" ], "modifiers": [], "additional_components": [ "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10639026": { "compartment": "compartment_171062", "id": "reaction_10639026", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638950", "species_10638940", "species_10638945" ], "products": [ "species_10638952" ], "modifiers": [], "additional_components": [ "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "WBGene00003246", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10665465": { "compartment": "compartment_876", "id": "reaction_10665465", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10665981": { "compartment": "compartment_70101", "id": "reaction_10665981", "reactome": "R-CEL-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665977" ], "products": [ "species_10665979" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10661675": { "compartment": "compartment_876", "id": "reaction_10661675", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_10642505" ], "products": [ "species_10642524" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29420", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10609414": { "compartment": "compartment_70101", "id": "reaction_10609414", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602407" ], "products": [ "species_10609412" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634222": { "compartment": "compartment_876", "id": "reaction_10634222", "reactome": "R-CEL-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10629224" ], "modifiers": [ [ "species_10634211", "catalyst" ], [ "species_10634220", "inhibitor" ], [ "species_10634216", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5082" ] }, "reaction_10664063": { "compartment": "compartment_70101", "id": "reaction_10664063", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10657704": { "compartment": "compartment_70101", "id": "reaction_10657704", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657699", "species_113592" ], "products": [ "species_10657701", "species_29370" ], "modifiers": [ [ "species_10657699", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928" ] }, "reaction_10639068": { "compartment": "compartment_984", "id": "reaction_10639068", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639050" ], "products": [ "species_10639066", "species_10639032" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00003246" ] }, "reaction_10631286": { "compartment": "compartment_876", "id": "reaction_10631286", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631284" ], "products": [ "species_10609280", "species_10612190" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038" ] }, "reaction_10640145": { "compartment": "compartment_70101", "id": "reaction_10640145", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640137" ], "products": [ "species_10640143" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "Q23089", "WBGene00002078", "P41932", "WBGene00003920", "O44326", "WBGene00001979" ] }, "reaction_10639544": { "compartment": "compartment_7660", "id": "reaction_10639544", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10639320" ], "products": [ "species_10639542" ], "modifiers": [], "additional_components": [ "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "P34545", "WBGene00000366", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10643280": { "compartment": "compartment_876", "id": "reaction_10643280", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643276" ], "products": [ "species_10643278" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10665545": { "compartment": "compartment_70101", "id": "reaction_10665545", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665533", "species_10645503" ], "products": [ "species_10665537" ], "modifiers": [ [ "species_10665543", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q18268", "WBGene00003966", "pubchem.compound:73292904" ] }, "reaction_10641377": { "compartment": "compartment_70101", "id": "reaction_10641377", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612014", "species_10641373" ], "products": [ "species_10641375" ], "modifiers": [], "additional_components": [ "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10635641": { "compartment": "compartment_70101", "id": "reaction_10635641", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10629362" ], "products": [ "species_10635623" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665516": { "compartment": "compartment_70101", "id": "reaction_10665516", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607835" ], "products": [ "species_10665507", "species_29370" ], "modifiers": [ [ "species_10665513", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "species_30991", "H2KYN2", "WBGene00015650" ] }, "reaction_10664691": { "compartment": "compartment_70101", "id": "reaction_10664691", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10664678" ], "products": [ "species_29370", "species_10664684" ], "modifiers": [ [ "species_10610899", "catalyst" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10648862": { "compartment": "compartment_7660", "id": "reaction_10648862", "reactome": "R-CEL-5692779", "name": "p-S182 MAPKAPK5 phosphorylates FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10648859" ], "modifiers": [ [ "species_10638831", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10648164": { "compartment": "compartment_70101", "id": "reaction_10648164", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648138" ], "products": [ "species_10648129" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10630128": { "compartment": "compartment_876", "id": "reaction_10630128", "reactome": "R-CEL-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10608459" ], "products": [ "species_10630119" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10639653": { "compartment": "compartment_7660", "id": "reaction_10639653", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639649", "species_10639647" ], "products": [ "species_10639318", "species_10639651" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424", "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q21227", "WBGene00000156", "O44326", "WBGene00001979", "Q20595", "WBGene00006424" ] }, "reaction_10617040": { "compartment": "compartment_70101", "id": "reaction_10617040", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609408", "species_113592" ], "products": [ "species_29370", "species_10617037" ], "modifiers": [ [ "species_10609408", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635629": { "compartment": "compartment_70101", "id": "reaction_10635629", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635623" ], "products": [ "species_10635627" ], "modifiers": [], "additional_components": [ "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10639540": { "compartment": "compartment_7660", "id": "reaction_10639540", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605206", "species_10639320", "species_10605196" ], "products": [ "species_10639538" ], "modifiers": [], "additional_components": [ "WBGene00007110", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00018064", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064", "O44326", "WBGene00001979", "Q10666", "WBGene00004077" ] }, "reaction_10665743": { "compartment": "compartment_876", "id": "reaction_10665743", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_9674075" ], "products": [ "species_10617614" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=10368", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10639070": { "compartment": "compartment_20699", "id": "reaction_10639070", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639028" ], "products": [ "species_10639050" ], "modifiers": [], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10665520": { "compartment": "compartment_876", "id": "reaction_10665520", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604898", "species_10607835" ], "products": [ "species_10641023" ], "modifiers": [ [ "species_10665507", "inhibitor" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10617616": { "compartment": "compartment_70101", "id": "reaction_10617616", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617609", "species_113592" ], "products": [ "species_29370", "species_10617611" ], "modifiers": [ [ "species_10617609", "catalyst" ], [ "species_10617614", "inhibitor" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "LigandDisplayForward?ligandId=10368", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "LigandDisplayForward?ligandId=5698", "LigandDisplayForward?ligandId=7882", "Q19238", "WBGene00021745" ] }, "reaction_10665745": { "compartment": "compartment_876", "id": "reaction_10665745", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609364", "species_9674079" ], "products": [ "species_10609376" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5659", "LigandDisplayForward?ligandId=9175", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5656", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=5890", "LigandDisplayForward?ligandId=7426", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "LigandDisplayForward?ligandId=5659", "Q10656", "WBGene00001184", "LigandDisplayForward?ligandId=5678", "LigandDisplayForward?ligandId=5890", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "LigandDisplayForward?ligandId=9175", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "Q19238", "WBGene00021745", "LigandDisplayForward?ligandId=5687", "LigandDisplayForward?ligandId=7426", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "LigandDisplayForward?ligandId=5936", "LigandDisplayForward?ligandId=5891", "LigandDisplayForward?ligandId=5711", "LigandDisplayForward?ligandId=5697", "LigandDisplayForward?ligandId=5713", "LigandDisplayForward?ligandId=5656", "O18008", "WBGene00021745" ] }, "reaction_10635241": { "compartment": "compartment_70101", "id": "reaction_10635241", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_10635225", "species_29370" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10635635": { "compartment": "compartment_70101", "id": "reaction_10635635", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_10635631" ], "products": [ "species_10635633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10659092": { "compartment": "compartment_70101", "id": "reaction_10659092", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659088", "species_10622260" ], "products": [ "species_10659090" ], "modifiers": [], "additional_components": [ "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10630135": { "compartment": "compartment_876", "id": "reaction_10630135", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10630132", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10638958": { "compartment": "compartment_20699", "id": "reaction_10638958", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638952" ], "products": [ "species_10638956" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503" ] }, "reaction_10657399": { "compartment": "compartment_70101", "id": "reaction_10657399", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10625343" ], "products": [ "species_10657396" ], "modifiers": [ [ "species_10625343", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00004829", "WBGene00004829", "WBGene00004829" ] }, "reaction_10631237": { "compartment": "compartment_70101", "id": "reaction_10631237", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10612130" ], "products": [ "species_10612134" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10643283": { "compartment": "compartment_876", "id": "reaction_10643283", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643278" ], "products": [ "species_29370", "species_10618313", "species_10642526" ], "modifiers": [ [ "species_10617742", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10665468": { "compartment": "compartment_876", "id": "reaction_10665468", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837" ], "products": [ "species_10608583" ], "modifiers": [ [ "species_10607837", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10658628": { "compartment": "compartment_984", "id": "reaction_10658628", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617342" ], "products": [ "species_10609394", "species_10609276", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10602377": { "compartment": "compartment_17940", "id": "reaction_10602377", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10617380": { "compartment": "compartment_70101", "id": "reaction_10617380", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10615471" ], "products": [ "species_10617378" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00006410", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q95PX0", "WBGene00006410", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10648160": { "compartment": "compartment_70101", "id": "reaction_10648160", "reactome": "R-CEL-5687121", "name": "p-S MAPKAPK5 phosphorylates HSPB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642534" ], "products": [ "species_29370", "species_10648149" ], "modifiers": [ [ "species_10648157", "catalyst" ] ], "additional_components": [ "WBGene00021943", "WBGene00021943", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10657390": { "compartment": "compartment_70101", "id": "reaction_10657390", "reactome": "R-CEL-8848611", "name": "Phosphorylated PXN recruits the CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636369", "species_10657386" ], "products": [ "species_10657388" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419", "WBGene00016197", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10617078": { "compartment": "compartment_70101", "id": "reaction_10617078", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617074" ], "products": [ "species_10617076" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q9NAD6", "WBGene00013111", "Q10656", "WBGene00001184", "Q20977", "WBGene00010251", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10642518": { "compartment": "compartment_876", "id": "reaction_10642518", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617912" ], "products": [ "species_29370", "species_10642515" ], "modifiers": [ [ "species_10642501", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "species_112275", "P34722", "WBGene00006599", "species_74016" ] }, "reaction_10664080": { "compartment": "compartment_70101", "id": "reaction_10664080", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664076", "species_10664058" ], "products": [ "species_10664078" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10646973": { "compartment": "compartment_70101", "id": "reaction_10646973", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646960", "species_29356" ], "products": [ "species_10646968", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10647020": { "compartment": "compartment_876", "id": "reaction_10647020", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646912", "species_10646941" ], "products": [ "species_10647018" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10665548": { "compartment": "compartment_876", "id": "reaction_10665548", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665539" ], "products": [ "species_10642764", "species_10645503", "species_10604898", "species_10607835" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "WBGene00002335" ] }, "reaction_10609386": { "compartment": "compartment_70101", "id": "reaction_10609386", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10602421" ], "products": [ "species_10609384" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10635677": { "compartment": "compartment_70101", "id": "reaction_10635677", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635266", "species_10612022" ], "products": [ "species_10635675" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q19404", "WBGene00008748" ] }, "reaction_10634132": { "compartment": "compartment_70101", "id": "reaction_10634132", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634129" ], "modifiers": [ [ "species_10627446", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10639322": { "compartment": "compartment_7660", "id": "reaction_10639322", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639318", "species_10611936" ], "products": [ "species_10639320", "species_10628319", "species_10639314" ], "modifiers": [], "additional_components": [ "O17695", "WBGene00001834", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "WBGene00001979", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "WBGene00001834", "O02482", "WBGene00006773" ] }, "reaction_10634230": { "compartment": "compartment_876", "id": "reaction_10634230", "reactome": "R-CEL-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634211", "species_113592" ], "products": [ "species_29370", "species_10634206" ], "modifiers": [ [ "species_10615184", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "WBGene00005077" ] }, "reaction_10647265": { "compartment": "compartment_876", "id": "reaction_10647265", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10647259" ], "products": [ "species_10647263", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ], [ "species_10647209", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "WBGene00003030" ] }, "reaction_10647219": { "compartment": "compartment_876", "id": "reaction_10647219", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647024" ], "products": [ "species_29370", "species_10647217" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10634202": { "compartment": "compartment_876", "id": "reaction_10634202", "reactome": "R-CEL-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629231", "species_10634198" ], "products": [ "species_10634200" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "P24348", "WBGene00002299", "Q9XX42", "WBGene00020106", "Q8I7I5", "WBGene00004395", "G5ECJ6", "WBGene00000812", "G5EFK8", "WBGene00008779", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10609417": { "compartment": "compartment_70101", "id": "reaction_10609417", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10609412", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N5D3", "WBGene00004947", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10645710": { "compartment": "compartment_7660", "id": "reaction_10645710", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645706", "species_10611936" ], "products": [ "species_10645708" ], "modifiers": [], "additional_components": [ "A0A1N7SZG1", "WBGene00015716", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949", "WBGene00001979", "A0A1N7SZG1", "WBGene00015716", "O44326", "WBGene00001979", "Q23045", "WBGene00001182", "Q20201", "WBGene00004950", "Q8T3B9", "WBGene00004771", "Q21305", "WBGene00004949" ] }, "reaction_10643579": { "compartment": "compartment_7660", "id": "reaction_10643579", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611936", "species_10643575" ], "products": [ "species_10643577" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00007053", "O61845", "WBGene00007053", "O44326", "WBGene00001979" ] }, "reaction_10646962": { "compartment": "compartment_70101", "id": "reaction_10646962", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635257", "species_10646952" ], "products": [ "species_10646960" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10617360": { "compartment": "compartment_984", "id": "reaction_10617360", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609272", "species_10617356" ], "products": [ "species_10617358" ], "modifiers": [], "additional_components": [ "WBGene00004249", "CHEBI:18137", "CHEBI:17421", "P17139", "WBGene00001263", "CHEBI:18137", "Q9N413", "WBGene00004249", "CHEBI:17421", "P17139", "WBGene00001263" ] }, "reaction_10657409": { "compartment": "compartment_70101", "id": "reaction_10657409", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657402", "species_10605408" ], "products": [ "species_10657404" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10635470": { "compartment": "compartment_70101", "id": "reaction_10635470", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263" ], "products": [ "species_10635468" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10639738": { "compartment": "compartment_7660", "id": "reaction_10639738", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10639703" ], "products": [ "species_77502", "species_10639715" ], "modifiers": [ [ "species_10639735", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q27484", "WBGene00001915", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "O44447", "WBGene00015330", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "Q10666", "WBGene00004077", "G5EFZ3", "WBGene00012458" ] }, "reaction_10639030": { "compartment": "compartment_20699", "id": "reaction_10639030", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638954", "species_10639016" ], "products": [ "species_10639028" ], "modifiers": [], "additional_components": [ "WBGene00003246", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857" ] }, "reaction_10642512": { "compartment": "compartment_876", "id": "reaction_10642512", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642509" ], "products": [ "species_29370", "species_10642479" ], "modifiers": [ [ "species_10604441", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10635253": { "compartment": "compartment_70101", "id": "reaction_10635253", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635201", "species_10635210" ], "products": [ "species_10635212" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10612216": { "compartment": "compartment_876", "id": "reaction_10612216", "reactome": "R-CEL-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611811", "species_10611783" ], "products": [ "species_10611813" ], "modifiers": [], "additional_components": [ "Q09488", "WBGene00004860", "P50488", "WBGene00000900", "P50488", "WBGene00000900", "Q09488", "WBGene00004860" ] }, "reaction_10635251": { "compartment": "compartment_70101", "id": "reaction_10635251", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_113592" ], "products": [ "species_29370", "species_10635248" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10611755": { "compartment": "compartment_7660", "id": "reaction_10611755", "reactome": "R-CEL-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607878", "species_10611751" ], "products": [ "species_10611753" ], "modifiers": [], "additional_components": [ "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EDM7", "WBGene00000901", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10647134": { "compartment": "compartment_876", "id": "reaction_10647134", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10647124" ], "products": [ "species_10647131" ], "modifiers": [ [ "species_10647124", "catalyst" ] ], "additional_components": [ "WBGene00006727", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "species_29438" ] }, "reaction_10665384": { "compartment": "compartment_20699", "id": "reaction_10665384", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665346", "species_200993" ], "products": [ "species_10665366", "species_76194" ], "modifiers": [ [ "species_10665381", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10647164": { "compartment": "compartment_20699", "id": "reaction_10647164", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647160", "species_10646952" ], "products": [ "species_10647162" ], "modifiers": [], "additional_components": [ "WBGene00013457", "WBGene00003030", "Q07292", "WBGene00003030", "Q9U1V1", "WBGene00013457" ] }, "reaction_10639023": { "compartment": "compartment_17963", "id": "reaction_10639023", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639000" ], "products": [ "species_10639016" ], "modifiers": [ [ "species_10639021", "catalyst" ] ], "additional_components": [ "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "Q10459", "WBGene00003395", "P34889", "WBGene00000858", "G5EG05", "WBGene00001188", "Q27886", "WBGene00003029", "P34888", "WBGene00000857", "WBGene00010670" ] }, "reaction_10635639": { "compartment": "compartment_70101", "id": "reaction_10635639", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635621", "species_10635263" ], "products": [ "species_10635637" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10665440": { "compartment": "compartment_876", "id": "reaction_10665440", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607833", "species_29356" ], "products": [ "species_8848337", "species_10607835" ], "modifiers": [ [ "species_10665433", "catalyst" ], [ "species_10665435", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10639074": { "compartment": "compartment_20699", "id": "reaction_10639074", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638956" ], "products": [ "species_10638954", "species_10638950", "species_10638940" ], "modifiers": [], "additional_components": [ "Q21053", "WBGene00006933", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q9XW41", "WBGene00006503", "WBGene00003246", "WBGene00006503", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234" ] }, "reaction_10617748": { "compartment": "compartment_70101", "id": "reaction_10617748", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617721", "species_10617742" ], "products": [ "species_10617744", "species_10617746" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "O62422", "WBGene00012532" ] }, "reaction_10609286": { "compartment": "compartment_876", "id": "reaction_10609286", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10609282" ], "products": [ "species_10609284" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004038", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10643316": { "compartment": "compartment_876", "id": "reaction_10643316", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10643309" ], "products": [ "species_29370", "species_10643313" ], "modifiers": [ [ "species_10618313", "catalyst" ] ], "additional_components": [ "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10631289": { "compartment": "compartment_876", "id": "reaction_10631289", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609284" ], "products": [ "species_29370", "species_10631284" ], "modifiers": [ [ "species_10609284", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q22070", "WBGene00004038", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10617362": { "compartment": "compartment_70101", "id": "reaction_10617362", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10617312" ], "products": [ "species_10617314" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9NHC3", "WBGene00000416", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q95XA9", "WBGene00021238", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665502": { "compartment": "compartment_70101", "id": "reaction_10665502", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10634127" ], "products": [ "species_10634220" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "LigandDisplayForward?ligandId=5686", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=7717", "LigandDisplayForward?ligandId=5667", "LigandDisplayForward?ligandId=7643", "Q18688", "WBGene00000915", "LigandDisplayForward?ligandId=7944", "LigandDisplayForward?ligandId=5675", "LigandDisplayForward?ligandId=7883", "LigandDisplayForward?ligandId=11580", "LigandDisplayForward?ligandId=5692", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "LigandDisplayForward?ligandId=5686" ] }, "reaction_10648147": { "compartment": "compartment_70101", "id": "reaction_10648147", "reactome": "R-CEL-5687101", "name": "p-T182 MAPKAPK5 phosphorylates FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648136" ], "products": [ "species_29370", "species_10648138" ], "modifiers": [ [ "species_10648144", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647202": { "compartment": "compartment_70101", "id": "reaction_10647202", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10647083" ], "products": [ "species_29370", "species_10647199" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10611733": { "compartment": "compartment_70101", "id": "reaction_10611733", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611729", "species_10607715" ], "products": [ "species_10611731" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666054": { "compartment": "compartment_263163", "id": "reaction_10666054", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_29356" ], "products": [ "species_10666051", "species_29372" ], "modifiers": [ [ "species_10666039", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_29370", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10630126": { "compartment": "compartment_876", "id": "reaction_10630126", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10630123", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P24348", "WBGene00002299", "G5EDP9", "WBGene00000001", "G5EFK8", "WBGene00008779" ] }, "reaction_10646970": { "compartment": "compartment_70101", "id": "reaction_10646970", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646968" ], "products": [ "species_10646912", "species_10635257" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10648126": { "compartment": "compartment_7660", "id": "reaction_10648126", "reactome": "R-CEL-5687088", "name": "PKA phosphorylates MAPKAPK5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10638817" ], "products": [ "species_113582", "species_10648121" ], "modifiers": [ [ "species_10648123", "catalyst" ] ], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "WBGene00002189" ] }, "reaction_10665350": { "compartment": "compartment_12045", "id": "reaction_10665350", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665341", "species_71284" ], "products": [ "species_71285", "species_10665346" ], "modifiers": [ [ "species_10650360", "catalyst" ], [ "species_10665348", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216667", "P91402", "WBGene00019710", "species_216667", "pubchem.compound:6918831", "P91402", "WBGene00019710" ] }, "reaction_10665437": { "compartment": "compartment_876", "id": "reaction_10665437", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10665433" ], "products": [ "species_10665435" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q5FC17", "WBGene00044003", "species_9647934", "Q9BL52", "WBGene00044003", "Q21221", "WBGene00045192", "Q7JKU8", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10611834": { "compartment": "compartment_876", "id": "reaction_10611834", "reactome": "R-CEL-201510", "name": "PI3K synthesizes PIP3 downstream of ALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10611831", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10612132": { "compartment": "compartment_70101", "id": "reaction_10612132", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612122", "species_113592" ], "products": [ "species_29370", "species_10612130" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665372": { "compartment": "compartment_876", "id": "reaction_10665372", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665366" ], "products": [ "species_10607833" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10646948": { "compartment": "compartment_876", "id": "reaction_10646948", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10646939" ], "products": [ "species_10646941" ], "modifiers": [ [ "species_10646946", "catalyst" ] ], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00004014" ] }, "reaction_10635472": { "compartment": "compartment_70101", "id": "reaction_10635472", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362" ], "products": [ "species_10629366" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10665568": { "compartment": "compartment_876", "id": "reaction_10665568", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607837", "species_10602421" ], "products": [ "species_10665566" ], "modifiers": [], "additional_components": [ "P22981", "WBGene00002335", "species_29438", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P22981", "WBGene00002335", "species_29438", "G5EDP9", "WBGene00000001" ] }, "reaction_10643318": { "compartment": "compartment_876", "id": "reaction_10643318", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617742", "species_10642526" ], "products": [ "species_10643276" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_179838", "Q45FX5", "WBGene00006887", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_179838", "Q45FX5", "WBGene00006887", "species_29438" ] }, "reaction_10664074": { "compartment": "compartment_17906", "id": "reaction_10664074", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664068", "species_10664058" ], "products": [ "species_10664072" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10659203": { "compartment": "compartment_70101", "id": "reaction_10659203", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_113592" ], "products": [ "species_29370", "species_10659200" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10635272": { "compartment": "compartment_70101", "id": "reaction_10635272", "reactome": "R-CEL-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629362", "species_10635239" ], "products": [ "species_10635270" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21036", "WBGene00019102", "Q21036", "WBGene00019102", "Q19404", "WBGene00008748" ] }, "reaction_10609396": { "compartment": "compartment_984", "id": "reaction_10609396", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609392" ], "products": [ "species_10609394", "species_10609268" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10611815": { "compartment": "compartment_13231", "id": "reaction_10611815", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611731" ], "products": [ "species_10611751" ], "modifiers": [], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10666047": { "compartment": "compartment_263163", "id": "reaction_10666047", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666039", "species_10666043" ], "products": [ "species_10666045" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287", "O01501", "WBGene00000871", "Q22895", "WBGene00004780", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "Q19213", "WBGene00006922", "O01501", "WBGene00000871", "Q03206", "ced-10", "Q22895", "WBGene00004780", "Q9BL44", "WBGene00022177", "Q17796", "WBGene00004101", "Q17391", "WBGene00000838", "species_113592", "Q19213", "WBGene00006922", "Q94124", "WBGene00004287" ] }, "reaction_10611805": { "compartment": "compartment_17941", "id": "reaction_10611805", "reactome": "R-CEL-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611801" ], "products": [ "species_10611803", "species_10611729" ], "modifiers": [], "additional_components": [ "P50488", "WBGene00000900", "P45896", "WBGene00004857", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "Q02330", "WBGene00004856", "P50488", "WBGene00000900", "H2KZI9", "WBGene00000101", "Q09488", "WBGene00004860", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10641382": { "compartment": "compartment_70101", "id": "reaction_10641382", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641375", "species_10597908" ], "products": [ "species_10641379" ], "modifiers": [ [ "species_10641375", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00006727", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102" ] }, "reaction_10634209": { "compartment": "compartment_876", "id": "reaction_10634209", "reactome": "R-CEL-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10634206" ], "products": [ "species_29370", "species_10629229" ], "modifiers": [ [ "species_10634206", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779" ] }, "reaction_10648162": { "compartment": "compartment_7660", "id": "reaction_10648162", "reactome": "R-CEL-5687123", "name": "p-S115 MAPKAPK5 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648121" ], "products": [ "species_10648155" ], "modifiers": [], "additional_components": [ "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10647274": { "compartment": "compartment_876", "id": "reaction_10647274", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_29356" ], "products": [ "species_29372", "species_10647259" ], "modifiers": [ [ "species_10647271", "catalyst" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00012665" ] }, "reaction_10647211": { "compartment": "compartment_876", "id": "reaction_10647211", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647022", "species_113592" ], "products": [ "species_29370", "species_10647209" ], "modifiers": [ [ "species_10647189", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665" ] }, "reaction_10609410": { "compartment": "compartment_876", "id": "reaction_10609410", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609280", "species_10608501" ], "products": [ "species_10609408" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00005077", "G5EE56", "WBGene00005077", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10631282": { "compartment": "compartment_70101", "id": "reaction_10631282", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631254", "species_10597908" ], "products": [ "species_10631279" ], "modifiers": [ [ "species_10631254", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "WBGene00006727", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320", "Q22227", "WBGene00003241", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q23457", "WBGene00004320" ] }, "reaction_10617626": { "compartment": "compartment_70101", "id": "reaction_10617626", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617621", "species_113592" ], "products": [ "species_29370", "species_10617623" ], "modifiers": [ [ "species_10617621", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10665463": { "compartment": "compartment_876", "id": "reaction_10665463", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607827", "species_29420" ], "products": [ "species_10608583" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10639072": { "compartment": "compartment_171062", "id": "reaction_10639072", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639032" ], "products": [ "species_10638945" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10602395": { "compartment": "compartment_876", "id": "reaction_10602395", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602393" ], "products": [ "species_10602228" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10635619": { "compartment": "compartment_70101", "id": "reaction_10635619", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635222", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10609403": { "compartment": "compartment_70101", "id": "reaction_10609403", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10609398" ], "products": [ "species_29370", "species_10609400" ], "modifiers": [ [ "species_10609398", "catalyst" ] ], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q9N413", "WBGene00004249", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10634137": { "compartment": "compartment_70101", "id": "reaction_10634137", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634127", "species_10597908" ], "products": [ "species_10634134" ], "modifiers": [ [ "species_10627613", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "WBGene00006727", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "P24348", "WBGene00002299", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10665363": { "compartment": "compartment_70101", "id": "reaction_10665363", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665353", "species_2530486" ], "products": [ "species_111294", "species_10665357" ], "modifiers": [ [ "species_10637128", "catalyst" ], [ "species_10665361", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10612224": { "compartment": "compartment_947587", "id": "reaction_10612224", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612218", "species_10611729" ], "products": [ "species_10612222" ], "modifiers": [], "additional_components": [ "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "G5EDS9", "WBGene00006445", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10630279": { "compartment": "compartment_70101", "id": "reaction_10630279", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10630276", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "species_179838", "Q45FX5", "WBGene00006887" ] }, "reaction_10647255": { "compartment": "compartment_876", "id": "reaction_10647255", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647068", "species_10647073" ], "products": [ "species_10647075" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438", "WBGene00018218", "Q20655", "WBGene00001502", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "O16264", "WBGene00018218", "Q07292", "WBGene00003030", "G5EFD2", "WBGene00002239", "species_29438" ] }, "reaction_10635261": { "compartment": "compartment_70101", "id": "reaction_10635261", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635225", "species_10635257" ], "products": [ "species_10635259" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q19404", "WBGene00008748" ] }, "reaction_10665609": { "compartment": "compartment_876", "id": "reaction_10665609", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607842", "species_10665605" ], "products": [ "species_10665607" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891", "species_29438" ] }, "reaction_10665535": { "compartment": "compartment_876", "id": "reaction_10665535", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641023" ], "products": [ "species_10665533" ], "modifiers": [], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10665386": { "compartment": "compartment_70101", "id": "reaction_10665386", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637128", "species_9653479" ], "products": [ "species_10665361" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "Q19752", "WBGene00006465", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "O44501", "WBGene00019823", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030" ] }, "reaction_10664082": { "compartment": "compartment_70101", "id": "reaction_10664082", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10664058" ], "products": [ "species_29372", "species_10664060" ], "modifiers": [ [ "species_10664058", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "species_29420", "Q94263", "WBGene00019544", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10659095": { "compartment": "compartment_70101", "id": "reaction_10659095", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659090", "species_29356" ], "products": [ "species_10659088", "species_10622802", "species_29372" ], "modifiers": [ [ "species_10659090", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10664688": { "compartment": "compartment_13231", "id": "reaction_10664688", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664678" ], "products": [ "species_10614393" ], "modifiers": [ [ "species_10664686", "inhibitor" ] ], "additional_components": [ "WBGene00000168", "WBGene00000168", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P41990", "WBGene00000168" ] }, "reaction_10611757": { "compartment": "compartment_7660", "id": "reaction_10611757", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611751" ], "products": [], "modifiers": [ [ "species_10607906", "catalyst" ] ], "additional_components": [ "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10665541": { "compartment": "compartment_70101", "id": "reaction_10665541", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642764", "species_10665537" ], "products": [ "species_10665539" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288", "P22981", "WBGene00002335", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_29438", "Q19705", "WBGene00001358", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q18268", "WBGene00003966", "G5EEG0", "WBGene00000286", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10657393": { "compartment": "compartment_876", "id": "reaction_10657393", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10635280" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10657388", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q09476", "WBGene00016197", "Q8STE5", "WBGene00000426", "G5EEN3", "WBGene00000419" ] }, "reaction_10657407": { "compartment": "compartment_70101", "id": "reaction_10657407", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657404" ], "products": [ "species_10657402", "species_10605406", "species_29372" ], "modifiers": [ [ "species_10657404", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "WBGene00010374", "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10641386": { "compartment": "compartment_70101", "id": "reaction_10641386", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641379" ], "products": [ "species_10641373", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "WBGene00009738", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10642497": { "compartment": "compartment_70101", "id": "reaction_10642497", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10642479" ], "products": [ "species_29370", "species_10642494" ], "modifiers": [ [ "species_10642479", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599" ] }, "reaction_10635268": { "compartment": "compartment_70101", "id": "reaction_10635268", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635263", "species_113592" ], "products": [ "species_29370", "species_10635266" ], "modifiers": [ [ "species_10635227", "catalyst" ], [ "species_10635239", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047", "Q21036", "WBGene00019102" ] }, "reaction_10658626": { "compartment": "compartment_984", "id": "reaction_10658626", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617340" ], "products": [ "species_10609274", "species_10658622" ], "modifiers": [ [ "species_10606421", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "O17798", "WBGene00002232", "P51559", "WBGene00000254" ] }, "reaction_10666049": { "compartment": "compartment_263163", "id": "reaction_10666049", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10666037" ], "products": [ "species_10666039" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "Q94124", "WBGene00004287", "Q03206", "ced-10", "Q9BL44", "WBGene00022177", "species_113592", "Q94124", "WBGene00004287" ] }, "reaction_10624150": { "compartment": "compartment_876", "id": "reaction_10624150", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561049", "species_29406" ], "products": [ "species_561075", "species_561078" ], "modifiers": [ [ "species_10624147", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "LigandDisplayForward?ligandId=1231", "species_561052", "CHEBI:104011", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621694": { "compartment": "compartment_984", "id": "reaction_10621694", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10621687", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10621668": { "compartment": "compartment_876", "id": "reaction_10621668", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10621588": { "compartment": "compartment_876", "id": "reaction_10621588", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_374935" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10621585", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10621101": { "compartment": "compartment_876", "id": "reaction_10621101", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621098", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624015": { "compartment": "compartment_876", "id": "reaction_10624015", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10624012", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q23501", "WBGene00003843", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "A0A238UKL7", "WBGene00019408", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10620434": { "compartment": "compartment_876", "id": "reaction_10620434", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10620431", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10621605": { "compartment": "compartment_70101", "id": "reaction_10621605", "reactome": "R-CEL-444007", "name": "GAT1-3 mediate Na+/Cl- dependent GABA transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_188972", "species_74113" ], "products": [ "species_352011", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621602", "catalyst" ] ], "additional_components": [ "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623992": { "compartment": "compartment_876", "id": "reaction_10623992", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10623984", "catalyst" ], [ "species_10623990", "inhibitor" ] ], "additional_components": [ "WBGene00022348", "WBGene00004393" ] }, "reaction_10616675": { "compartment": "compartment_984", "id": "reaction_10616675", "reactome": "R-CEL-379393", "name": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_380873" ], "products": [ "species_159362", "species_83910" ], "modifiers": [ [ "species_10616672", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10616012": { "compartment": "compartment_876", "id": "reaction_10616012", "reactome": "R-CEL-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375468", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_375459" ], "modifiers": [ [ "species_10616009", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_29612", "CHEBI:58045", "CHEBI:16958", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "species_29432", "species_73590", "species_111707", "species_29612", "CHEBI:58045", "species_174390", "species_352002", "species_159549", "species_29444", "species_29468", "CHEBI:57427", "species_29500", "species_29702", "WBGene00004908" ] }, "reaction_10624152": { "compartment": "compartment_876", "id": "reaction_10624152", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621636": { "compartment": "compartment_876", "id": "reaction_10621636", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10621633", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "species_390899", "species_380873", "species_374935", "species_209794", "species_114523", "WBGene00000295" ] }, "reaction_10621682": { "compartment": "compartment_876", "id": "reaction_10621682", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10624222": { "compartment": "compartment_876", "id": "reaction_10624222", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10624219", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621616": { "compartment": "compartment_876", "id": "reaction_10621616", "reactome": "R-CEL-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113", "species_188972" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10611405", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10621045": { "compartment": "compartment_876", "id": "reaction_10621045", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10621042", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10624050": { "compartment": "compartment_876", "id": "reaction_10624050", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621088": { "compartment": "compartment_876", "id": "reaction_10621088", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433138" ], "products": [ "species_83910", "species_76190" ], "modifiers": [ [ "species_10621085", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10615145": { "compartment": "compartment_876", "id": "reaction_10615145", "reactome": "R-CEL-351987", "name": "SLC6A6-mediated uptake of taurine and beta-alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352024", "species_74113", "species_188972" ], "products": [ "species_352019", "species_83910", "species_352022" ], "modifiers": [ [ "species_10615142", "catalyst" ] ], "additional_components": [ "CHEBI:16958", "CHEBI:15891", "species_73590", "CHEBI:15891", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10624048": { "compartment": "compartment_876", "id": "reaction_10624048", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621083": { "compartment": "compartment_876", "id": "reaction_10621083", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433123" ], "products": [ "species_83910", "species_29434" ], "modifiers": [ [ "species_10621080", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10623957": { "compartment": "compartment_876", "id": "reaction_10623957", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10623954", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "CHEBI:42820", "species_549282", "CHEBI:641", "species_141324", "species_374935", "CHEBI:6801", "CHEBI:15854", "species_353560", "CHEBI:46020", "species_209794", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622172": { "compartment": "compartment_876", "id": "reaction_10622172", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10621679", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10621070": { "compartment": "compartment_876", "id": "reaction_10621070", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_174375", "species_83910" ], "modifiers": [ [ "species_10621067", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10624187": { "compartment": "compartment_876", "id": "reaction_10624187", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_561071", "species_29406" ], "products": [ "species_561075", "species_561062" ], "modifiers": [ [ "species_10624184", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176496", "species_176501", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10615148": { "compartment": "compartment_876", "id": "reaction_10615148", "reactome": "R-CEL-352029", "name": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_352007" ], "products": [ "species_83910", "species_352022", "species_351982" ], "modifiers": [ [ "species_10611378", "catalyst" ] ], "additional_components": [ "CHEBI:48950", "CHEBI:16958", "species_352003", "species_6798202", "species_73590", "CHEBI:48950", "species_352003", "species_6798202", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "G5EF43", "WBGene00004910" ] }, "reaction_10623996": { "compartment": "compartment_876", "id": "reaction_10623996", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "species_390899", "species_380873", "species_549282", "CHEBI:641", "species_374935", "CHEBI:6801", "species_114523", "CHEBI:46020", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "species_351164", "species_209794", "CHEBI:31941", "CHEBI:65133", "species_6798162", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621631": { "compartment": "compartment_876", "id": "reaction_10621631", "reactome": "R-CEL-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029", "species_74113", "species_188972" ], "products": [ "species_29424", "species_83910", "species_352022" ], "modifiers": [ [ "species_10621628", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EE39", "WBGene00004906" ] }, "reaction_10624189": { "compartment": "compartment_876", "id": "reaction_10624189", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10624045", "catalyst" ] ], "additional_components": [ "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:47499", "CHEBI:47781", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10621119": { "compartment": "compartment_876", "id": "reaction_10621119", "reactome": "R-CEL-433698", "name": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10621116", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10624243": { "compartment": "compartment_876", "id": "reaction_10624243", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_597604" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10624240", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "LigandDisplayForward?ligandId=2342", "LigandDisplayForward?ligandId=5535", "WBGene00008273" ] }, "reaction_10615811": { "compartment": "compartment_876", "id": "reaction_10615811", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10622170": { "compartment": "compartment_876", "id": "reaction_10622170", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10621665", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10620466": { "compartment": "compartment_876", "id": "reaction_10620466", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638", "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022", "species_264618" ], "modifiers": [ [ "species_10620463", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10621677": { "compartment": "compartment_876", "id": "reaction_10621677", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10621674", "catalyst" ] ], "additional_components": [ "Q22947", "WBGene00004358", "Q17463", "WBGene00004359" ] }, "reaction_10665294": { "compartment": "compartment_876", "id": "reaction_10665294", "reactome": "R-CEL-9645220", "name": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433683", "species_351626" ], "products": [ "species_70106", "species_433686" ], "modifiers": [ [ "species_10665291", "catalyst" ] ], "additional_components": [ "CHEBI:37054", "species_73909", "species_9749790", "species_9749785", "species_113557", "species_6807616", "species_29666", "CHEBI:37054", "species_9749790", "species_9749785", "species_113557", "species_6807616", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10621114": { "compartment": "compartment_876", "id": "reaction_10621114", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_433111" ], "products": [ "species_433124", "species_83910" ], "modifiers": [ [ "species_10621111", "catalyst" ] ], "additional_components": [ "species_29654", "species_1650769", "species_29654", "species_1650769", "P46556", "WBGene00007138", "P32739", "WBGene00003518", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10612194": { "compartment": "compartment_70101", "id": "reaction_10612194", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612187", "species_179856" ], "products": [ "species_10612192" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10612202": { "compartment": "compartment_70101", "id": "reaction_10612202", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10612199", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10625850": { "compartment": "compartment_74700", "id": "reaction_10625850", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10625847", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10625825": { "compartment": "compartment_74700", "id": "reaction_10625825", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10602374", "catalyst" ] ], "additional_components": [ "Q9TYW1", "WBGene00021952", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10598971": { "compartment": "compartment_5460", "id": "reaction_10598971", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10598968", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10599029": { "compartment": "compartment_5460", "id": "reaction_10599029", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10599026", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10598935": { "compartment": "compartment_5460", "id": "reaction_10598935", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10598932", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57427", "species_29702", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10599039": { "compartment": "compartment_5460", "id": "reaction_10599039", "reactome": "R-CEL-70885", "name": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_573404", "species_113526" ], "products": [ "species_29362", "species_113529", "species_30004" ], "modifiers": [ [ "species_10599036", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10623795": { "compartment": "compartment_5460", "id": "reaction_10623795", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10598958", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10623787": { "compartment": "compartment_70101", "id": "reaction_10623787", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_508182", "species_29406" ], "modifiers": [ [ "species_10598916", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "CHEBI:58045", "CHEBI:57427", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10598991": { "compartment": "compartment_5460", "id": "reaction_10598991", "reactome": "R-CEL-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10598988", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10599011": { "compartment": "compartment_5460", "id": "reaction_10599011", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10599008", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10599001": { "compartment": "compartment_5460", "id": "reaction_10599001", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10599021": { "compartment": "compartment_5460", "id": "reaction_10599021", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10598945": { "compartment": "compartment_5460", "id": "reaction_10598945", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10598942", "catalyst" ] ], "additional_components": [ "species_113596", "G5EEH6", "WBGene00015326" ] }, "reaction_10598908": { "compartment": "compartment_5460", "id": "reaction_10598908", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10598905", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O17953", "WBGene00010794", "O45924", "WBGene00012713", "species_113596" ] }, "reaction_10598981": { "compartment": "compartment_5460", "id": "reaction_10598981", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10598978", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10599047": { "compartment": "compartment_5460", "id": "reaction_10599047", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599044", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10648280": { "compartment": "compartment_70101", "id": "reaction_10648280", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607380" ], "products": [ "species_10607378", "species_10607380" ], "modifiers": [ [ "species_10648277", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "WBGene00006727", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10648264": { "compartment": "compartment_7660", "id": "reaction_10648264", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648253", "species_10648260" ], "products": [ "species_10648262" ], "modifiers": [], "additional_components": [ "WBGene00013924", "WBGene00006446", "O17850", "WBGene00006446", "Q23451", "WBGene00013924" ] }, "reaction_10649878": { "compartment": "compartment_7660", "id": "reaction_10649878", "reactome": "R-CEL-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649863" ], "products": [ "species_10649875", "species_10648387" ], "modifiers": [ [ "species_10649863", "catalyst" ] ], "additional_components": [ "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249", "P0CG71", "WBGene00006727", "G5EF71", "WBGene00003180", "Q8WT44", "WBGene00000874", "B7WN96", "WBGene00001251", "Q9XUW7", "WBGene00001311", "P28515", "WBGene00001249" ] }, "reaction_10649549": { "compartment": "compartment_7660", "id": "reaction_10649549", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649544" ], "products": [ "species_10648387", "species_10649546" ], "modifiers": [ [ "species_10649544", "catalyst" ] ], "additional_components": [ "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "D9N129", "WBGene00007428", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10649902": { "compartment": "compartment_7660", "id": "reaction_10649902", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607906", "species_10649898" ], "products": [ "species_10649900" ], "modifiers": [], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "P46504", "WBGene00017754", "Q20617", "WBGene00006719", "Q9XVR6", "WBGene00007718", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344" ] }, "reaction_10659851": { "compartment": "compartment_70101", "id": "reaction_10659851", "reactome": "R-CEL-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659849" ], "products": [ "species_10611220" ], "modifiers": [ [ "species_10655826", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "WBGene00001112" ] }, "reaction_10646598": { "compartment": "compartment_70101", "id": "reaction_10646598", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646587", "species_10646594" ], "products": [ "species_10646596" ], "modifiers": [], "additional_components": [ "WBGene00006724", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q09444", "WBGene00006724", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648301": { "compartment": "compartment_70101", "id": "reaction_10648301", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648297", "species_10646594" ], "products": [ "species_10648299" ], "modifiers": [], "additional_components": [ "WBGene00006856", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "Q17361", "WBGene00006856", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648390": { "compartment": "compartment_7660", "id": "reaction_10648390", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648346" ], "products": [ "species_10648387", "species_10648352" ], "modifiers": [ [ "species_10648346", "catalyst" ] ], "additional_components": [ "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "P0CG71", "WBGene00006727", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912" ] }, "reaction_10649596": { "compartment": "compartment_7660", "id": "reaction_10649596", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649591" ], "products": [ "species_10649593", "species_10648387" ], "modifiers": [ [ "species_10649591", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10658620": { "compartment": "compartment_70101", "id": "reaction_10658620", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648512" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10658617", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00006727", "WBGene00021733" ] }, "reaction_10648492": { "compartment": "compartment_7660", "id": "reaction_10648492", "reactome": "R-CEL-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648487", "species_113518" ], "products": [ "species_10648489", "species_10597874" ], "modifiers": [ [ "species_10648487", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240", "WBGene00006727", "P09588", "WBGene00001877", "Q8WT44", "WBGene00000874", "Q27485", "WBGene00001909", "Q23429", "WBGene00014240" ] }, "reaction_10648531": { "compartment": "compartment_70101", "id": "reaction_10648531", "reactome": "R-CEL-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10648504" ], "products": [ "species_10648506", "species_10648528" ], "modifiers": [ [ "species_10648504", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "G5EDI8", "WBGene00001090", "Q93413", "WBGene00008400" ] }, "reaction_10649660": { "compartment": "compartment_7660", "id": "reaction_10649660", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649653" ], "products": [ "species_10649657", "species_10648387" ], "modifiers": [ [ "species_10649653", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "P0CG71", "WBGene00006727", "Q9XTT9", "WBGene00004506", "H2L0L4", "WBGene00020461", "O17607", "WBGene00007784", "P34638", "WBGene00000863" ] }, "reaction_10649710": { "compartment": "compartment_70101", "id": "reaction_10649710", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649706", "species_10628847" ], "products": [ "species_10649708" ], "modifiers": [], "additional_components": [ "WBGene00008547", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q19132", "WBGene00008547" ] }, "reaction_10648284": { "compartment": "compartment_7660", "id": "reaction_10648284", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646315", "species_10648260" ], "products": [ "species_10648282" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "P54812", "WBGene00008053", "O17850", "WBGene00006446" ] }, "reaction_10648649": { "compartment": "compartment_70101", "id": "reaction_10648649", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648645", "species_10648641" ], "products": [ "species_10648647" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "O76671", "WBGene00019185", "P46504", "WBGene00017754", "Q9XVR6", "WBGene00007718", "Q22038", "WBGene00004357", "P46504", "WBGene00017754", "O76671", "WBGene00019185", "Q9XVR6", "WBGene00007718" ] }, "reaction_10646629": { "compartment": "compartment_70101", "id": "reaction_10646629", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646592", "species_10598108" ], "products": [ "species_10646594" ], "modifiers": [], "additional_components": [ "WBGene00016981", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q09289", "WBGene00016981", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10648625": { "compartment": "compartment_70101", "id": "reaction_10648625", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648616", "species_29356" ], "products": [ "species_10648620", "species_10648622" ], "modifiers": [ [ "species_10648616", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10649635": { "compartment": "compartment_7660", "id": "reaction_10649635", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649630" ], "products": [ "species_10649632", "species_10597874" ], "modifiers": [ [ "species_10649630", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885", "WBGene00006727", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27484", "WBGene00001915", "Q9GRV2", "WBGene00013506", "P04255", "WBGene00001885" ] }, "reaction_10649701": { "compartment": "compartment_70101", "id": "reaction_10649701", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649694", "species_29356" ], "products": [ "species_10649698", "species_10597908" ], "modifiers": [ [ "species_10649694", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "WBGene00006727", "Q21733", "WBGene00000904", "O01467", "WBGene00019259", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856" ] }, "reaction_10648584": { "compartment": "compartment_70101", "id": "reaction_10648584", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648579", "species_29356" ], "products": [ "species_1131871", "species_10648581" ], "modifiers": [ [ "species_10648579", "catalyst" ] ], "additional_components": [ "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727", "Q965V9", "WBGene00006723", "Q8MNY0", "WBGene00006722", "Q9UAV3", "WBGene00006721", "P0CG71", "WBGene00006727" ] }, "reaction_10656887": { "compartment": "compartment_263163", "id": "reaction_10656887", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656855", "species_10656885" ], "products": [ "species_10656865" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10657132": { "compartment": "compartment_263163", "id": "reaction_10657132", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657128" ], "products": [ "species_10657130" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O18230", "WBGene00013302", "Q94392", "WBGene00003818" ] }, "reaction_10656916": { "compartment": "compartment_70101", "id": "reaction_10656916", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656912", "species_10656873" ], "products": [ "species_10656914" ], "modifiers": [], "additional_components": [ "WBGene00010040", "Q20758", "WBGene00000187", "species_29438", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10656741": { "compartment": "compartment_263163", "id": "reaction_10656741", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10656732" ], "products": [ "species_10656738", "species_29420" ], "modifiers": [ [ "species_10656732", "catalyst" ] ], "additional_components": [ "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "species_29438", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656881": { "compartment": "compartment_263163", "id": "reaction_10656881", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656865", "species_10656873" ], "products": [ "species_10656879" ], "modifiers": [], "additional_components": [ "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10656734": { "compartment": "compartment_263163", "id": "reaction_10656734", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656722", "species_10656710" ], "products": [ "species_10656732" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "P34213", "WBGene00004269", "Q09417", "WBGene00011071", "Q22782", "WBGene00004270" ] }, "reaction_10656925": { "compartment": "compartment_70101", "id": "reaction_10656925", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656921", "species_10656873" ], "products": [ "species_10656923" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10656907": { "compartment": "compartment_263163", "id": "reaction_10656907", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656903", "species_10656879" ], "products": [ "species_10656905" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "Q9N3C8", "WBGene00021841", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q9N3C8", "WBGene00021841", "Q18013", "WBGene00002220", "Q20758", "WBGene00000187", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10651166": { "compartment": "compartment_7660", "id": "reaction_10651166", "reactome": "R-CEL-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651163", "species_113560" ], "products": [ "species_2485002", "species_10647489" ], "modifiers": [ [ "species_10651163", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647505": { "compartment": "compartment_7660", "id": "reaction_10647505", "reactome": "R-CEL-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647500", "species_113560" ], "products": [ "species_2485002", "species_10647502" ], "modifiers": [ [ "species_10647500", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647494": { "compartment": "compartment_7660", "id": "reaction_10647494", "reactome": "R-CEL-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647489", "species_29358" ], "products": [ "species_113582", "species_10647491", "species_10614888" ], "modifiers": [ [ "species_10647489", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648887": { "compartment": "compartment_7660", "id": "reaction_10648887", "reactome": "R-CEL-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647502", "species_29358" ], "products": [ "species_113582", "species_10648884", "species_10614888" ], "modifiers": [ [ "species_10647502", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "WBGene00000227", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10603971": { "compartment": "compartment_5460", "id": "reaction_10603971", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603969": { "compartment": "compartment_5460", "id": "reaction_10603969", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77322" ], "products": [ "species_29362", "species_77320", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10603967": { "compartment": "compartment_5460", "id": "reaction_10603967", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10649824": { "compartment": "compartment_7660", "id": "reaction_10649824", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10649819" ], "products": [ "species_10649821", "species_113541" ], "modifiers": [ [ "species_10649819", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823" ] }, "reaction_10649832": { "compartment": "compartment_7660", "id": "reaction_10649832", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649821" ], "products": [ "species_10649830", "species_10648549" ], "modifiers": [ [ "species_10598275", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q19366", "WBGene00008722", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "O62218", "WBGene00009368", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "P90829", "WBGene00008645", "Q23457", "WBGene00004320", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "WBGene00002985" ] }, "reaction_10614353": { "compartment": "compartment_7660", "id": "reaction_10614353", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614344", "species_77087" ], "products": [ "species_77502", "species_10614350" ], "modifiers": [ [ "species_10614344", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9GYS1", "WBGene00003224", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614340": { "compartment": "compartment_7660", "id": "reaction_10614340", "reactome": "R-CEL-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10614318" ], "products": [ "species_10614337", "species_77502" ], "modifiers": [ [ "species_10614318", "catalyst" ] ], "additional_components": [ "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10614320": { "compartment": "compartment_7660", "id": "reaction_10614320", "reactome": "R-CEL-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10614316" ], "products": [ "species_10614318" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27894", "WBGene00001878", "O17514", "WBGene00003220", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q9GYS1", "WBGene00003224", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10660998": { "compartment": "compartment_7660", "id": "reaction_10660998", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10638301" ], "products": [ "species_10660996" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00003599", "H2L0K3", "WBGene00003599", "G5EFQ5", "WBGene00004393" ] }, "reaction_10658639": { "compartment": "compartment_7660", "id": "reaction_10658639", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658635", "species_10658633" ], "products": [ "species_10658637" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10666150": { "compartment": "compartment_12045", "id": "reaction_10666150", "reactome": "R-CEL-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10617216" ], "products": [ "species_10617224" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10637461": { "compartment": "compartment_984", "id": "reaction_10637461", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637458", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q19777", "WBGene00009109" ] }, "reaction_10666201": { "compartment": "compartment_876", "id": "reaction_10666201", "reactome": "R-CEL-9728748", "name": "Bitter compound binds bitter taste receptor (TAS2R)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666195", "species_9728981" ], "products": [ "species_10666199" ], "modifiers": [], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678", "CHEBI:73236", "CHEBI:10093", "CHEBI:9162", "CHEBI:351346", "CHEBI:7789", "LigandDisplayForward?ligandId=5535", "CHEBI:3768", "CHEBI:73226", "CHEBI:5547", "CHEBI:73235", "LigandDisplayForward?ligandId=7074", "CHEBI:2948", "CHEBI:2366", "CHEBI:73222", "CHEBI:44975", "CHEBI:23736", "CHEBI:3941", "pubchem.compound:14217", "CHEBI:8206", "CHEBI:138412", "LigandDisplayForward?ligandId=86", "CHEBI:27641", "pubchem.compound:3032338", "pubchem.compound:19518", "CHEBI:4325", "pubchem.compound:69794", "CHEBI:32111", "CHEBI:3419", "CHEBI:34750", "CHEBI:36773", "CHEBI:73237", "CHEBI:73224", "CHEBI:27613", "CHEBI:2825", "CHEBI:82431", "species_39703", "pubchem.compound:2723704", "CHEBI:42638", "species_76328", "CHEBI:17814", "CHEBI:69441", "species_8855492", "CHEBI:2853", "CHEBI:82346", "CHEBI:28179", "LigandDisplayForward?ligandId=1224", "LigandDisplayForward?ligandId=6976", "CHEBI:26948", "CHEBI:83501", "CHEBI:59039", "CHEBI:46261", "CHEBI:3445", "CHEBI:3944", "CHEBI:28973", "CHEBI:16150", "CHEBI:73232", "CHEBI:18305", "CHEBI:28579", "CHEBI:15854", "CHEBI:3614", "CHEBI:8502", "CHEBI:17698", "pubchem.compound:71648", "CHEBI:69236", "CHEBI:2622", "CHEBI:8692", "CHEBI:4638", "CHEBI:73239", "species_39427", "CHEBI:23359", "CHEBI:28241", "CHEBI:48923", "CHEBI:73228", "CHEBI:17682", "CHEBI:16226", "CHEBI:65408", "CHEBI:7939", "CHEBI:3193", "pubchem.compound:2723593", "species_217315", "CHEBI:27732", "CHEBI:73231", "CHEBI:16962", "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "Q9N2V6", "WBGene00001678" ] }, "reaction_10666153": { "compartment": "compartment_12045", "id": "reaction_10666153", "reactome": "R-CEL-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10617224", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10660101": { "compartment": "compartment_70101", "id": "reaction_10660101", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_8876310" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10660098", "catalyst" ] ], "additional_components": [ "species_8869604", "species_113557", "species_6807616", "species_197230", "species_113557", "species_6807616", "WBGene00014092" ] }, "reaction_10620062": { "compartment": "compartment_876", "id": "reaction_10620062", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10620059", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10619969": { "compartment": "compartment_876", "id": "reaction_10619969", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10619966", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10645786": { "compartment": "compartment_70101", "id": "reaction_10645786", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10645783", "catalyst" ] ], "additional_components": [ "G5EFB2", "WBGene00013963", "Q94225", "WBGene00018283", "G5EDS5", "WBGene00017464", "O17951", "WBGene00010789", "G5EC30", "WBGene00012259", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "G5EEA7", "WBGene00010788" ] }, "reaction_10618811": { "compartment": "compartment_876", "id": "reaction_10618811", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10618808", "catalyst" ] ], "additional_components": [ "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151", "Q95XP5", "WBGene00003153" ] }, "reaction_10618823": { "compartment": "compartment_114521", "id": "reaction_10618823", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_427899" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10618816", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10619486": { "compartment": "compartment_876", "id": "reaction_10619486", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10619483", "catalyst" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "H2KYP2", "WBGene00003567", "G5EF08", "WBGene00003566", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10618036": { "compartment": "compartment_70101", "id": "reaction_10618036", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618031" ], "products": [ "species_29420", "species_10618033" ], "modifiers": [ [ "species_10618031", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q9BIG5", "WBGene00001666", "species_29370", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678" ] }, "reaction_10614196": { "compartment": "compartment_7660", "id": "reaction_10614196", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_29358" ], "products": [ "species_113582", "species_10611182" ], "modifiers": [ [ "species_10611163", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10614200": { "compartment": "compartment_7660", "id": "reaction_10614200", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10636661": { "compartment": "compartment_70101", "id": "reaction_10636661", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357697", "species_5359016" ], "products": [ "species_5357660", "species_5359011", "species_29432" ], "modifiers": [ [ "species_10636658", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10631233": { "compartment": "compartment_70101", "id": "reaction_10631233", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10631230", "catalyst" ] ], "additional_components": [ "Q22820", "WBGene00000515", "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631053": { "compartment": "compartment_12045", "id": "reaction_10631053", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10631050", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "O44732", "WBGene00018797", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631200": { "compartment": "compartment_12045", "id": "reaction_10631200", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10631197", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10649500": { "compartment": "compartment_5460", "id": "reaction_10649500", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_5696414" ], "products": [ "species_113548", "species_5693978", "species_113532" ], "modifiers": [ [ "species_10649497", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10631211": { "compartment": "compartment_12045", "id": "reaction_10631211", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10631208", "catalyst" ] ], "additional_components": [ "Q9XXT5", "WBGene00010425", "species_109496" ] }, "reaction_10649269": { "compartment": "compartment_12045", "id": "reaction_10649269", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612768", "species_10612734" ], "products": [ "species_10612770" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "G5EDE8", "WBGene00002070", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q22170", "WBGene00002071" ] }, "reaction_10649279": { "compartment": "compartment_12045", "id": "reaction_10649279", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612677", "species_10612714" ], "products": [ "species_10612716" ], "modifiers": [], "additional_components": [ "WBGene00011648", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "A0A1T5HUM0", "WBGene00001618", "Q21415", "WBGene00001614", "Q10914", "WBGene00001613", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615" ] }, "reaction_10657200": { "compartment": "compartment_6791047", "id": "reaction_10657200", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657195" ], "products": [ "species_10649098", "species_10657193" ], "modifiers": [ [ "species_10657195", "catalyst" ] ], "additional_components": [ "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "species_29420", "Q9UAQ6", "WBGene00004266", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649271": { "compartment": "compartment_13959", "id": "reaction_10649271", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649098", "species_10612881", "species_10649147" ], "products": [ "species_10649149" ], "modifiers": [], "additional_components": [ "species_29420", "Q9UAQ6", "WBGene00004266", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "O02173", "WBGene00021046", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649264": { "compartment": "compartment_6791047", "id": "reaction_10649264", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10649260" ], "products": [ "species_10649262" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10612886": { "compartment": "compartment_13959", "id": "reaction_10612886", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612785" ], "products": [ "species_10612883", "species_10612622", "species_10612781", "species_29372", "species_10612881" ], "modifiers": [ [ "species_10612785", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "WBGene00022678", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "Q9TXZ9", "WBGene00015164", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10657197": { "compartment": "compartment_6791047", "id": "reaction_10657197", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655844", "species_10657193" ], "products": [ "species_10657195" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00013196", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10649386": { "compartment": "compartment_12045", "id": "reaction_10649386", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612772", "species_10612652", "species_10612904" ], "products": [ "species_10612774" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10612896": { "compartment": "compartment_70101", "id": "reaction_10612896", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10612888" ], "products": [ "species_10612652", "species_29420" ], "modifiers": [ [ "species_10612893", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "species_29438", "Q23445", "WBGene00022678", "WBGene00010496" ] }, "reaction_10649171": { "compartment": "compartment_12045", "id": "reaction_10649171", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612898", "species_10612598", "species_10612670" ], "products": [ "species_10649169" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853" ] }, "reaction_10649345": { "compartment": "compartment_6791047", "id": "reaction_10649345", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649252", "species_10649277" ], "products": [ "species_10649343", "species_10649179", "species_10649260", "species_10649186" ], "modifiers": [], "additional_components": [ "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9TXZ9", "WBGene00015164", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q20364", "WBGene00009654", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "G5EGG0", "WBGene00010713" ] }, "reaction_10649267": { "compartment": "compartment_6791047", "id": "reaction_10649267", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10649262" ], "products": [ "species_10649229", "species_10649241", "species_10649213", "species_10649258", "species_10649250", "species_10649236", "species_29372", "species_10649234" ], "modifiers": [ [ "species_10649262", "catalyst" ] ], "additional_components": [ "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "WBGene00009654", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "Q9TXZ9", "WBGene00015164", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "WBGene00007128", "WBGene00043064", "Q20364", "WBGene00009654", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "O62387", "WBGene00012150", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q94241", "WBGene00018853", "P41941", "WBGene00007128", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10649156": { "compartment": "compartment_13959", "id": "reaction_10649156", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649149", "species_29438" ], "products": [ "species_10649153", "species_29420" ], "modifiers": [ [ "species_10649149", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "species_29420", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649194": { "compartment": "compartment_20699", "id": "reaction_10649194", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649179", "species_10649153", "species_10649186" ], "products": [ "species_10649192" ], "modifiers": [], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338", "G5EGG0", "WBGene00010713", "Q19371", "WBGene00004755", "Q9UAQ6", "WBGene00004266", "Q9U2Z1", "WBGene00004754", "Q9N3Y1", "WBGene00021536", "Q22361", "WBGene00011648", "Q17697", "WBGene00001615", "Q22170", "WBGene00002071", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q93330", "WBGene00007956", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q9N4A7", "WBGene00003806", "Q19989", "WBGene00018017", "G5EGG0", "WBGene00010713", "Q9NA81", "WBGene00013259", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q20100", "WBGene00018088", "A0A1T5HUM0", "WBGene00001618", "G4SNB8", "WBGene00044604", "G5EE40", "WBGene00005642", "species_29438", "O01623", "WBGene00001616", "Q9XU81", "WBGene00010699", "Q9TXZ9", "WBGene00015164", "O02173", "WBGene00021046", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "B1GRL5", "WBGene00077643", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "B1V899", "WBGene00022138", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "Q94241", "WBGene00018853", "P34605", "WBGene00014222", "G5EGP8", "WBGene00000788", "G5EFY6", "WBGene00011338" ] }, "reaction_10649173": { "compartment": "compartment_12045", "id": "reaction_10649173", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774", "species_10612622", "species_10612781" ], "products": [ "species_10612783" ], "modifiers": [], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q19371", "WBGene00004755", "Q9U1W1", "WBGene00006565", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "H2KZQ8", "WBGene00017419", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "P34643", "WBGene00013985", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649389": { "compartment": "compartment_70101", "id": "reaction_10649389", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612774" ], "products": [ "species_10612772", "species_10612888", "species_29372", "species_10612904" ], "modifiers": [ [ "species_10612774", "catalyst" ] ], "additional_components": [ "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788", "Q19371", "WBGene00004755", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "Q9U2Z1", "WBGene00004754", "O01623", "WBGene00001616", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5EGP8", "WBGene00000788", "species_29420", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q22361", "WBGene00011648", "Q22170", "WBGene00002071", "Q17697", "WBGene00001615", "Q23368", "WBGene00004756", "O17365", "WBGene00005643", "Q10914", "WBGene00001613", "Q9XVQ1", "WBGene00009708", "P41941", "WBGene00007128", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A0A1T5HUM0", "WBGene00001618", "G5EE40", "WBGene00005642", "O01623", "WBGene00001616", "species_29438", "Q23445", "WBGene00022678", "G5ECY2", "WBGene00005644", "P34299", "WBGene00001612", "Q8MXV8", "WBGene00001617", "Q21415", "WBGene00001614", "Q20797", "WBGene00006373", "A9Z1L1", "WBGene00005648", "O45520", "WBGene00009708", "G5EDE8", "WBGene00002070", "G5EGP8", "WBGene00000788" ] }, "reaction_10649167": { "compartment": "compartment_12045", "id": "reaction_10649167", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612664", "species_10612670", "species_10612666" ], "products": [ "species_10612672" ], "modifiers": [], "additional_components": [ "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "WBGene00004754", "WBGene00004755", "Q19371", "WBGene00004755", "Q20797", "WBGene00006373", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128" ] }, "reaction_10618547": { "compartment": "compartment_876", "id": "reaction_10618547", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618543", "species_10618528" ], "products": [ "species_10618545" ], "modifiers": [], "additional_components": [ "Q966F9", "WBGene00000071", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q966F9", "WBGene00000071" ] }, "reaction_10618534": { "compartment": "compartment_876", "id": "reaction_10618534", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10616740" ], "products": [ "species_10616742" ], "modifiers": [], "additional_components": [ "species_374935", "species_209794", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10618532": { "compartment": "compartment_876", "id": "reaction_10618532", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618530" ], "products": [ "species_10618522", "species_10618528" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "species_29438", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10618540": { "compartment": "compartment_876", "id": "reaction_10618540", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618538" ], "products": [ "species_10618530", "species_29420" ], "modifiers": [ [ "species_10616742", "catalyst" ] ], "additional_components": [ "species_29420", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q9N2V6", "WBGene00001678", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "species_374935", "species_209794" ] }, "reaction_10664419": { "compartment": "compartment_17963", "id": "reaction_10664419", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9033793", "species_205689" ], "modifiers": [ [ "species_10664416", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664437": { "compartment": "compartment_17963", "id": "reaction_10664437", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_9037036", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10656475": { "compartment": "compartment_7660", "id": "reaction_10656475", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10656463" ], "products": [ "species_113582", "species_10656472" ], "modifiers": [ [ "species_10656463", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657117": { "compartment": "compartment_7660", "id": "reaction_10657117", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_29470", "species_29358", "species_113562", "species_10657112" ], "products": [ "species_10657114" ], "modifiers": [ [ "species_10657112", "catalyst" ], [ "species_10657112", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994" ] }, "reaction_10656512": { "compartment": "compartment_7660", "id": "reaction_10656512", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599971", "species_10656465" ], "products": [ "species_10656463" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "Q7YTH5", "WBGene00006390", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "P91868", "WBGene00001568", "G5EG47", "WBGene00010054", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EF68", "WBGene00006386", "G5EFV5", "WBGene00000408", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10657106": { "compartment": "compartment_7660", "id": "reaction_10657106", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657090" ], "products": [ "species_10657098", "species_10657092" ], "modifiers": [ [ "species_10657090", "catalyst" ], [ "species_10657104", "catalyst" ], [ "species_10600765", "catalyst" ] ], "additional_components": [ "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "species_430042", "Q966L5", 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"H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085", "WBGene00020480", "WBGene00020092" ] }, "reaction_10657202": { "compartment": "compartment_7660", "id": "reaction_10657202", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610160", "species_10600248", "species_10657114", "species_10599886" ], "products": [ "species_10657090" ], "modifiers": [], "additional_components": [ "WBGene00022192", "WBGene00017085", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O17869", "WBGene00009650", "G5EDW9", "WBGene00008361", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q93594", "WBGene00009141", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "O01483", "WBGene00015499", "Q9N554", "WBGene00021281", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "W6RQY9", "WBGene00022360", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "O18167", "WBGene00012234", "Q9U3K2", "WBGene00008642", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "A5Z2V1", "WBGene00009451", "E5QCH1", "WBGene00013877", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q8MYM8", "WBGene00012694", "H2KML7", "WBGene00013021", "Q9N5K2", "WBGene00019246", "Q9U267", "WBGene00013075", "Q9XW26", "WBGene00012735", "Q17749", "WBGene00015554", "Q22805", "WBGene00020827", "Q95ZM2", "WBGene00017608", "O44500", "WBGene00019822", "Q9N4E8", "WBGene00022192", "species_430042", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "B7WN63", "WBGene00000994", "Q966L5", "WBGene00017085" ] }, "reaction_10656510": { "compartment": "compartment_7660", "id": "reaction_10656510", "reactome": "R-CEL-6810235", "name": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656480", "species_10656472", "species_10656504", "species_10656498" ], "products": [ "species_10656508" ], "modifiers": [], "additional_components": [ "WBGene00011143", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q965S0", "WBGene00022400", "Q17694", "WBGene00015513", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q93338", "WBGene00007971", "Q22678", "WBGene00011926", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "A5Z2V1", "WBGene00009451", "O17869", "WBGene00009650", "P41934", "WBGene00000441", "Q9NEX2", "WBGene00013736", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "A5Z2V1", "WBGene00009451", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q9XW26", "WBGene00012735", "Q17694", "WBGene00015513", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "P91868", "WBGene00001568", "G5EFV5", "WBGene00000408", "G5EF68", "WBGene00006386", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "P30641", "WBGene00011143", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q7YTH5", "WBGene00006390", "P34281", "WBGene00015347", "Q17684", "WBGene00007355", "P34425", "WBGene00000507", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "O16991", "WBGene00006648", "Q22678", "WBGene00011926", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054" ] }, "reaction_10640732": { "compartment": "compartment_70101", "id": "reaction_10640732", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640717" ], "products": [ "species_29370", "species_10640729" ], "modifiers": [ [ "species_10640717", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640614": { "compartment": "compartment_876", "id": "reaction_10640614", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640606", "species_179856" ], "products": [ "species_10640608" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532" ] }, "reaction_10640600": { "compartment": "compartment_70101", "id": "reaction_10640600", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640597", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95YD4", "WBGene00002213", "Q19475", "WBGene00001164", "A0A0K3AQN0", "WBGene00013682" ] }, "reaction_10640694": { "compartment": "compartment_70101", "id": "reaction_10640694", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640690", "species_10640684" ], "products": [ "species_10640692" ], "modifiers": [], "additional_components": [ "WBGene00008805", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640702": { "compartment": "compartment_876", "id": "reaction_10640702", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613333", "species_10617725" ], "products": [ "species_10640700" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q17850", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640833": { "compartment": "compartment_70101", "id": "reaction_10640833", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640743", "species_10613352" ], "products": [ "species_10640745" ], "modifiers": [], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "WBGene00015704", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640998": { "compartment": "compartment_876", "id": "reaction_10640998", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640991" ], "products": [ "species_10640996" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10640764": { "compartment": "compartment_70101", "id": "reaction_10640764", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621901", "species_113592" ], "products": [ "species_29370", "species_10622006" ], "modifiers": [ [ "species_10640729", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640612": { "compartment": "compartment_876", "id": "reaction_10640612", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612317", "species_10633823", "species_10640608" ], "products": [ "species_10640610" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q8I4M6", "WBGene00007840", "species_29438", "Q19475", "WBGene00001164", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "Q8I4M6", "WBGene00007840", "Q8WTM6", "WBGene00021170", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "species_29438", "Q19475", "WBGene00001164", "Q05062", "WBGene00000390", "G5EEE7", "WBGene00006869", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "P53489", "WBGene00000200", "species_113592", "P91167", "WBGene00016729", "O61861", "WBGene00000205", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "O62422", "WBGene00012532", "P10984", "WBGene00000064" ] }, "reaction_10640761": { "compartment": "compartment_876", "id": "reaction_10640761", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10613331", "species_10640711" ], "products": [ "species_10640713", "species_114549" ], "modifiers": [ [ "species_10640711", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_111349", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640709": { "compartment": "compartment_70101", "id": "reaction_10640709", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640700" ], "products": [ "species_29370", "species_10640706" ], "modifiers": [ [ "species_10640700", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438" ] }, "reaction_10640753": { "compartment": "compartment_70101", "id": "reaction_10640753", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640745", "species_113592" ], "products": [ "species_29370", "species_10640750" ], "modifiers": [ [ "species_10640745", "catalyst" ] ], "additional_components": [ "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640994": { "compartment": "compartment_876", "id": "reaction_10640994", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10640750", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EGQ9", "WBGene00003774", "G5EE56", "WBGene00005077", "O01847", "WBGene00015704", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "species_159549", "species_113552", "G5EEH3", "WBGene00003775", "Q19475", "WBGene00001164" ] }, "reaction_10640758": { "compartment": "compartment_70101", "id": "reaction_10640758", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608729", "species_10640692" ], "products": [ "species_10640711" ], "modifiers": [], "additional_components": [ "WBGene00010776", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q19475", "WBGene00001164" ] }, "reaction_10640766": { "compartment": "compartment_70101", "id": "reaction_10640766", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640715", "species_10640713" ], "products": [ "species_10640717" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "species_29438", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q03206", "ced-10", "G5EEE7", "WBGene00006869", "G5EGQ3", "WBGene00003144", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q95PX0", "WBGene00006410", "Q17850", "WBGene00003911", "species_29438", "Q19475", "WBGene00001164" ] }, "reaction_10640841": { "compartment": "compartment_876", "id": "reaction_10640841", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605406" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10640838", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "G5EEE7", "WBGene00006869", "Q9U3M2", "WBGene00001163", "O44516", "WBGene00001165", "Q965J0", "WBGene00019487", "Q19475", "WBGene00001164" ] }, "reaction_10665741": { "compartment": "compartment_7660", "id": "reaction_10665741", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606498", "species_10665737" ], "products": [ "species_10665739" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "O17919", "WBGene00010478", "Q9TYM6", "WBGene00021655" ] }, "reaction_10642188": { "compartment": "compartment_12045", "id": "reaction_10642188", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642180" ], "products": [ "species_10642077" ], "modifiers": [ [ "species_10642185", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00010757" ] }, "reaction_10625508": { "compartment": "compartment_17963", "id": "reaction_10625508", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625506", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625528": { "compartment": "compartment_17963", "id": "reaction_10625528", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_10625526", "species_205687" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625518": { "compartment": "compartment_17963", "id": "reaction_10625518", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_205687", "species_10625516" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10634243": { "compartment": "compartment_17963", "id": "reaction_10634243", "reactome": "R-CEL-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625526" ], "products": [ "species_10634238", "species_205687" ], "modifiers": [ [ "species_10634240", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10625644": { "compartment": "compartment_17963", "id": "reaction_10625644", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625415" ], "products": [ "species_205687", "species_10625642" ], "modifiers": [], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901" ] }, "reaction_10625551": { "compartment": "compartment_20699", "id": "reaction_10625551", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625415", "species_914003" ], "products": [ "species_205687", "species_10625536" ], "modifiers": [ [ "species_10625548", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q20575", "WBGene00009849", "Q19421", "WBGene00008766" ] }, "reaction_10625655": { "compartment": "compartment_20699", "id": "reaction_10625655", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625536", "species_914003" ], "products": [ "species_205687", "species_10625652" ], "modifiers": [ [ "species_10625601", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10642136": { "compartment": "compartment_12045", "id": "reaction_10642136", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10642077" ], "products": [ "species_158602", "species_10642128" ], "modifiers": [ [ "species_10642133", "catalyst" ] ], "additional_components": [ "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "O18003", "WBGene00011269", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "Q19349", "WBGene00017376", "Q19791", "WBGene00001650", "Q19284", "WBGene00017309", "P90884", "WBGene00009958", "WBGene00022576" ] }, "reaction_10625634": { "compartment": "compartment_17963", "id": "reaction_10625634", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625559", "species_914003" ], "products": [ "species_10625567", "species_205687" ], "modifiers": [ [ "species_10625631", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641", "G5EBK7", "WBGene00001644", "G5ECK8", "WBGene00001626", "G5EEZ8", "WBGene00001640", "O02315", "WBGene00001642" ] }, "reaction_10625482": { "compartment": "compartment_20699", "id": "reaction_10625482", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10625407" ], "products": [ "species_205687", "species_10625415" ], "modifiers": [ [ "species_10625479", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34678", "WBGene00001628", "Q9U2C4", "WBGene00012934", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "O45293", "WBGene00001633", "Q7K755", "WBGene00001636", "O45947", "WBGene00001635", "O61397", "WBGene00001632" ] }, "reaction_10634322": { "compartment": "compartment_20699", "id": "reaction_10634322", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10625415" ], "products": [ "species_10625559", "species_205687" ], "modifiers": [ [ "species_10634319", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "O17747", "WBGene00021403", "O17053", "WBGene00021403", "O45579", "WBGene00021403", "O44563", "WBGene00044620", "G5ECT3", "WBGene00021403", "Q22900", "WBGene00021403", "O18184", "WBGene00021403", "Q18515", "WBGene00021403", "O16535", "WBGene00021403", "P41881", "WBGene00021403" ] }, "reaction_10629081": { "compartment": "compartment_24339", "id": "reaction_10629081", "reactome": "R-CEL-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629043" ], "products": [ "species_10629079" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629007": { "compartment": "compartment_171043", "id": "reaction_10629007", "reactome": "R-CEL-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629005" ], "products": [ "species_1236715", "species_10629003" ], "modifiers": [], "additional_components": [ "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629097": { "compartment": "compartment_21994", "id": "reaction_10629097", "reactome": "R-CEL-1236956", "name": "Engulfment of particulate antigen into phagocytic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629089" ], "products": [ "species_10629095", "species_1236714" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10629101": { "compartment": "compartment_70101", "id": "reaction_10629101", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10629083": { "compartment": "compartment_24339", "id": "reaction_10629083", "reactome": "R-CEL-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629079" ], "products": [ "species_10629005" ], "modifiers": [], "additional_components": [ "P34312", "WBGene00007399", "species_1236715", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191", "species_1236715", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "O01761", "WBGene00006820", "P91429", "WBGene00020191" ] }, "reaction_10629099": { "compartment": "compartment_876", "id": "reaction_10629099", "reactome": "R-CEL-1236958", "name": "Interaction of particulate antigens with dendritic cell receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236726", "species_10629087" ], "products": [ "species_10629089" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10649526": { "compartment": "compartment_12045", "id": "reaction_10649526", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10631021": { "compartment": "compartment_12045", "id": "reaction_10631021", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10631018", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910", "Q9NCE1", "WBGene00010408" ] }, "reaction_10630954": { "compartment": "compartment_12045", "id": "reaction_10630954", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657376": { "compartment": "compartment_12045", "id": "reaction_10657376", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10657373", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10630989": { "compartment": "compartment_12045", "id": "reaction_10630989", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630956": { "compartment": "compartment_12045", "id": "reaction_10630956", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10630975": { "compartment": "compartment_12045", "id": "reaction_10630975", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500594", "species_29356" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10630949", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10636052": { "compartment": "compartment_70101", "id": "reaction_10636052", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_265283" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636055": { "compartment": "compartment_70101", "id": "reaction_10636055", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10610247", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636060": { "compartment": "compartment_70101", "id": "reaction_10636060", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10636057", "catalyst" ] ], "additional_components": [ "Q09596", "WBGene00001753", "species_29450" ] }, "reaction_10614716": { "compartment": "compartment_70101", "id": "reaction_10614716", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10614713", "catalyst" ] ], "additional_components": [ "Q23280", "WBGene00022599", "Q21925", "WBGene00011239" ] }, "reaction_10661537": { "compartment": "compartment_70616", "id": "reaction_10661537", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10661534", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661604": { "compartment": "compartment_70616", "id": "reaction_10661604", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661580", "species_10661578" ], "products": [ "species_10661582" ], "modifiers": [], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10662558": { "compartment": "compartment_70616", "id": "reaction_10662558", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523", "species_10661513", "species_10661532", "species_10661518", "species_10661511" ], "products": [ "species_10661534" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00019296", "Q18874", "WBGene00008345", "WBGene00013462", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q9U3I4", "WBGene00008980", "Q95PZ2", "WBGene00013462" ] }, "reaction_10661609": { "compartment": "compartment_70616", "id": "reaction_10661609", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949220", "species_2889072" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10661606", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10661599": { "compartment": "compartment_70616", "id": "reaction_10661599", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661582" ], "products": [ "species_10661523", "species_10661578", "species_10661584" ], "modifiers": [ [ "species_10661596", "catalyst" ] ], "additional_components": [ "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "Q9U3I4", "WBGene00008980", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842", "WBGene00008980", "Q23295", "WBGene00013880", "Q95XN2", "WBGene00022159" ] }, "reaction_10661602": { "compartment": "compartment_70616", "id": "reaction_10661602", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661523" ], "products": [], "modifiers": [ [ "species_10661578", "catalyst" ] ], "additional_components": [ "WBGene00008980", "species_216667", "P50093", "WBGene00004015", "Q9BKU4", "WBGene00004014", "Q9N3T5", "WBGene00004978", "G5EDB6", "WBGene00021425", "Q2HQK3", "WBGene00044745", "P54813", "WBGene00010842" ] }, "reaction_10601291": { "compartment": "compartment_70101", "id": "reaction_10601291", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601287", "species_10601248" ], "products": [ "species_10601289" ], "modifiers": [], "additional_components": [ "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560" ] }, "reaction_10601565": { "compartment": "compartment_70101", "id": "reaction_10601565", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601289" ], "products": [ "species_10601199", "species_10601287", "species_29420" ], "modifiers": [ [ "species_10601287", "catalyst" ] ], "additional_components": [ "P34604", "WBGene00014221", "species_29420", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950", "P34604", "WBGene00014221", "G5EFF9", "WBGene00008670", "P80361", "WBGene00004090", "Q18994", "WBGene00008428", "Q9XWD5", "WBGene00012950" ] }, "reaction_10603965": { "compartment": "compartment_5460", "id": "reaction_10603965", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10603963": { "compartment": "compartment_5460", "id": "reaction_10603963", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77251", "species_113526" ], "products": [ "species_73871", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10644252": { "compartment": "compartment_876", "id": "reaction_10644252", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644249", "catalyst" ] ], "additional_components": [ "A0A4V0IK35", "WBGene00015867", "O45313", "WBGene00008307", "Q95XD1", "WBGene00022240", "O16638", "WBGene00021116" ] }, "reaction_10664085": { "compartment": "compartment_70101", "id": "reaction_10664085", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664090": { "compartment": "compartment_70101", "id": "reaction_10664090", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_9020474", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10618717": { "compartment": "compartment_876", "id": "reaction_10618717", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618713" ], "products": [ "species_10618715" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10618705": { "compartment": "compartment_984", "id": "reaction_10618705", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618701", "species_10618695" ], "products": [ "species_10618703" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10621227": { "compartment": "compartment_876", "id": "reaction_10621227", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621223", "species_10621215" ], "products": [ "species_10621225" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615528": { "compartment": "compartment_876", "id": "reaction_10615528", "reactome": "R-CEL-373746", "name": "SEMA4D interacts with CD45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615507", "species_10615524" ], "products": [ "species_10615526" ], "modifiers": [], "additional_components": [ "WBGene00009401", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q20019", "WBGene00009401" ] }, "reaction_10604168": { "compartment": "compartment_7660", "id": "reaction_10604168", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601975", "species_10601970", "species_10602616" ], "products": [ "species_10602618" ], "modifiers": [], "additional_components": [ "WBGene00006648", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10602624": { "compartment": "compartment_7660", "id": "reaction_10602624", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602065", "species_10602620" ], "products": [ "species_10602622" ], "modifiers": [], "additional_components": [ "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604166": { "compartment": "compartment_7660", "id": "reaction_10604166", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10602053" ], "products": [ "species_10602616" ], "modifiers": [], "additional_components": [ "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395" ] }, "reaction_10604170": { "compartment": "compartment_7660", "id": "reaction_10604170", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599973", "species_10602618" ], "products": [ "species_10602620" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O44625", "WBGene00004136", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10604172": { "compartment": "compartment_7660", "id": "reaction_10604172", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602622", "species_10601853" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10630113": { "compartment": "compartment_876", "id": "reaction_10630113", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10630110", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10629838": { "compartment": "compartment_876", "id": "reaction_10629838", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629835", "catalyst" ] ], "additional_components": [ "Q21529", "WBGene00006658", "P90863", "WBGene00006682", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659" ] }, "reaction_10629479": { "compartment": "compartment_876", "id": "reaction_10629479", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629476", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629865": { "compartment": "compartment_876", "id": "reaction_10629865", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629862", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10629773": { "compartment": "compartment_876", "id": "reaction_10629773", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629770", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10629494": { "compartment": "compartment_876", "id": "reaction_10629494", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10629491", "catalyst" ] ], "additional_components": [ "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151" ] }, "reaction_10629948": { "compartment": "compartment_876", "id": "reaction_10629948", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10629945", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q7YWY7", "WBGene00010784", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694" ] }, "reaction_10660945": { "compartment": "compartment_70101", "id": "reaction_10660945", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941", "species_10615184" ], "products": [ "species_10660943" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660953": { "compartment": "compartment_70101", "id": "reaction_10660953", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660941" ], "products": [ "species_10658641" ], "modifiers": [ [ "species_10615184", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "WBGene00005077" ] }, "reaction_10662401": { "compartment": "compartment_7660", "id": "reaction_10662401", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662397" ], "products": [ "species_10662399" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10658645": { "compartment": "compartment_7660", "id": "reaction_10658645", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658633", "species_10658641" ], "products": [ "species_10658643" ], "modifiers": [], "additional_components": [ "WBGene00000272", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662403": { "compartment": "compartment_70101", "id": "reaction_10662403", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662399" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10660951": { "compartment": "compartment_70101", "id": "reaction_10660951", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10660943" ], "products": [ "species_29370", "species_10660948", "species_10615184" ], "modifiers": [ [ "species_10660943", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00005077", "G5EE56", "WBGene00005077", "G5EFQ5", "WBGene00004393" ] }, "reaction_10615739": { "compartment": "compartment_876", "id": "reaction_10615739", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615735", "species_10615689" ], "products": [ "species_10615737" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10621789": { "compartment": "compartment_70101", "id": "reaction_10621789", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617725", "species_113592", "species_10605399" ], "products": [ "species_29370", "species_10617723", "species_10621786" ], "modifiers": [ [ "species_10617723", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "WBGene00003911", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "WBGene00003911" ] }, "reaction_10621774": { "compartment": "compartment_70101", "id": "reaction_10621774", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617630" ], "products": [ "species_10605399", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10618095": { "compartment": "compartment_70101", "id": "reaction_10618095", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612071", "species_113592", "species_10615689" ], "products": [ "species_10618093", "species_29370" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "Q5WRR1", "WBGene00006942", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10621778": { "compartment": "compartment_876", "id": "reaction_10621778", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608466", "species_10615689" ], "products": [ "species_10621776" ], "modifiers": [], "additional_components": [ "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P24348", "WBGene00002299" ] }, "reaction_10615733": { "compartment": "compartment_876", "id": "reaction_10615733", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615689" ], "products": [ "species_10615731" ], "modifiers": [], "additional_components": [ "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "C6KRM7", "WBGene00004372", "Q5WRR1", "WBGene00006942" ] }, "reaction_10614145": { "compartment": "compartment_70101", "id": "reaction_10614145", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614142", "species_29404" ], "products": [ "species_10614028" ], "modifiers": [ [ "species_10614142", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10614135": { "compartment": "compartment_984", "id": "reaction_10614135", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10614088" ], "products": [ "species_10614130", "species_10614132", "species_210382", "species_10614118", "species_10613945", "species_10614086", "species_10614100", "species_10614053" ], "modifiers": [ [ "species_10614088", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "species_74016", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10613856": { "compartment": "compartment_984", "id": "reaction_10613856", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_210382", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_29404", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ], [ "species_10613854", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624", "WBGene00017070" ] }, "reaction_10614091": { "compartment": "compartment_70101", "id": "reaction_10614091", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614028", "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048" ], "products": [ "species_10614088" ], "modifiers": [ [ "species_10614028", "catalyst" ], [ "species_10614068", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_113552", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "P34644", "WBGene00001135", "species_113552", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "G5EEK1", "WBGene00010755", "Q95XH1", "WBGene00022077", "Q10046", "WBGene00011556", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006752" ] }, "reaction_10636112": { "compartment": "compartment_5460", "id": "reaction_10636112", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10636120": { "compartment": "compartment_70616", "id": "reaction_10636120", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10636117", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10636123": { "compartment": "compartment_5460", "id": "reaction_10636123", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10636109", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10614597": { "compartment": "compartment_70101", "id": "reaction_10614597", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_76194", "species_264643" ], "modifiers": [ [ "species_10614594", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10614589": { "compartment": "compartment_70101", "id": "reaction_10614589", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10614584" ], "products": [ "species_70106", "species_10614586" ], "modifiers": [ [ "species_10614568", "catalyst" ] ], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10615286": { "compartment": "compartment_70101", "id": "reaction_10615286", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614586", "species_10614053", "species_10614048" ], "products": [ "species_10615283" ], "modifiers": [ [ "species_10614586", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_264643", "O02495", "WBGene00004897", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10615371": { "compartment": "compartment_876", "id": "reaction_10615371", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615283" ], "products": [ "species_10614130", "species_10614132", "species_10615368", "species_10614086", "species_10613945", "species_10614116", "species_10614053", "species_372533" ], "modifiers": [ [ "species_10615283", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006756", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "species_264643", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9N415", "WBGene00006513", "P34711", "WBGene00006756", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10645186": { "compartment": "compartment_261122", "id": "reaction_10645186", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645128" ], "products": [ "species_10645178" ], "modifiers": [ [ "species_10645184", "inhibitor" ] ], "additional_components": [ "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "Q21626", "WBGene00010974", "CHEBI:15996", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645954": { "compartment": "compartment_18730", "id": "reaction_10645954", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645950", "species_10645945" ], "products": [ "species_10645952" ], "modifiers": [], "additional_components": [ "WBGene00019536", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10645030": { "compartment": "compartment_13949", "id": "reaction_10645030", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645026", "species_10645008" ], "products": [ "species_10645028" ], "modifiers": [], "additional_components": [ "Q18286", "WBGene00016188", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "species_29438", "Q95ZS6", "WBGene00018869", "G5EFC1", "WBGene00004272", "O01803", "WBGene00004274", "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272" ] }, "reaction_10645054": { "compartment": "compartment_261122", "id": "reaction_10645054", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645028" ], "products": [ "species_10645052" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q18286", "WBGene00016188", "O61827", "WBGene00000487", "Q18406", "WBGene00016376", "Q9U1S7", "WBGene00004035", "A8WI01", "WBGene00000562", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "species_29438", "Q95ZS6", "WBGene00018869", "O01803", "WBGene00004274", "Q9XWS2", "WBGene00004753", "Q19262", "WBGene00017284", "Q7Z205", "WBGene00000563", "G5EEE2", "WBGene00006525", "Q20759", "WBGene00010045", "Q9N4C1", "WBGene00022295", "G5EFC1", "WBGene00004272", "Q03611", "WBGene00006526", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9U1S7", "WBGene00004035", "G5EEE2", "WBGene00006525", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295" ] }, "reaction_10645964": { "compartment": "compartment_18730", "id": "reaction_10645964", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645952" ], "modifiers": [ [ "species_10645950", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "WBGene00019536" ] }, "reaction_10645097": { "compartment": "compartment_70101", "id": "reaction_10645097", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644745", "species_10644720", "species_10644715", "species_10644735", "species_10644725", "species_10644710", "species_10644740", "species_10644730" ], "products": [ "species_10644747" ], "modifiers": [], "additional_components": [ "WBGene00019482", "WBGene00043992", "WBGene00000242", "WBGene00016744", "WBGene00010974", "WBGene00000241", "WBGene00000244", "WBGene00003892", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10645130": { "compartment": "compartment_876", "id": "reaction_10645130", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10645126", "species_10645104" ], "products": [ "species_10645128" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "A0A3B1DQQ4", "WBGene00006864", "A0A0K3AXD3", "WBGene00011372", "Q09502", "WBGene00008065", "H9G358", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "P34311", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q23033", "WBGene00020086", "Q18510", "WBGene00000193", "species_29438", "Q9NEZ7", "WBGene00000241", "A0A3B1DQQ4", "WBGene00006864", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "A0A2C9C3A4", "WBGene00018089", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "P34311", "WBGene00018089", "species_29438", "Q21626", "WBGene00010974", "Q9XVQ0", "WBGene00018089", "O01514", "WBGene00016744", "Q20841", "WBGene00018886", "Q19640", "WBGene00000242", "A0A0K3AXD3", "WBGene00011372", "Q18510", "WBGene00000193", "H9G358", "WBGene00018089", "Q9XW70", "WBGene00003892", "Q23033", "WBGene00020086" ] }, "reaction_10645972": { "compartment": "compartment_18730", "id": "reaction_10645972", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645958" ], "products": [ "species_10645956", "species_10645950", "species_10645943" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "species_111349", "WBGene00019536", "WBGene00006843" ] }, "reaction_10645961": { "compartment": "compartment_18730", "id": "reaction_10645961", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645952" ], "products": [ "species_10645958" ], "modifiers": [ [ "species_10645952", "catalyst" ] ], "additional_components": [ "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "species_111349", "O45379", "WBGene00000188", "Q966I6", "WBGene00019536", "Q10658", "WBGene00006843", "CHEBI:15996" ] }, "reaction_10644756": { "compartment": "compartment_2132649", "id": "reaction_10644756", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644747", "species_10644752" ], "products": [ "species_10644754" ], "modifiers": [], "additional_components": [ "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744", "WBGene00010045", "Q19640", "WBGene00000242", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q20759", "WBGene00010045", "Q23049", "WBGene00000244", "Q5CZ52", "WBGene00043992", "Q9XW70", "WBGene00003892", "Q21626", "WBGene00010974", "O01514", "WBGene00016744" ] }, "reaction_10618833": { "compartment": "compartment_70101", "id": "reaction_10618833", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10618830", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "P91119", "WBGene00016328" ] }, "reaction_10631241": { "compartment": "compartment_70101", "id": "reaction_10631241", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612134", "species_1497857" ], "products": [ "species_29870", "species_10631239" ], "modifiers": [], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10630704": { "compartment": "compartment_70101", "id": "reaction_10630704", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630697", "species_10630689" ], "products": [ "species_10630699" ], "modifiers": [], "additional_components": [ "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10655778": { "compartment": "compartment_5460", "id": "reaction_10655778", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10655775", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10638217": { "compartment": "compartment_70101", "id": "reaction_10638217", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638215" ], "products": [ "species_111294", "species_76577", "species_10602923" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10610819": { "compartment": "compartment_70101", "id": "reaction_10610819", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10610816", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10638500": { "compartment": "compartment_70101", "id": "reaction_10638500", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638497", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10608120" ], "modifiers": [ [ "species_10638497", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10610781": { "compartment": "compartment_70101", "id": "reaction_10610781", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10611056": { "compartment": "compartment_876", "id": "reaction_10611056", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10611053", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207", "Q20734", "WBGene00043980" ] }, "reaction_10610836": { "compartment": "compartment_70101", "id": "reaction_10610836", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10630865": { "compartment": "compartment_70101", "id": "reaction_10630865", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630860", "species_113592" ], "products": [ "species_29370", "species_10630712" ], "modifiers": [ [ "species_10630862", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216667", "O02058", "WBGene00015010", "WBGene00015650" ] }, "reaction_10655786": { "compartment": "compartment_5460", "id": "reaction_10655786", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10655783", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10660041": { "compartment": "compartment_17927", "id": "reaction_10660041", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10660038", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10610809": { "compartment": "compartment_70101", "id": "reaction_10610809", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10610806", "catalyst" ] ], "additional_components": [ "P90755", "WBGene00007755" ] }, "reaction_10643425": { "compartment": "compartment_70101", "id": "reaction_10643425", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_71285", "species_549282" ], "modifiers": [ [ "species_10608188", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10656369": { "compartment": "compartment_17951", "id": "reaction_10656369", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10656366", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10638520": { "compartment": "compartment_5460", "id": "reaction_10638520", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159297", "species_10599214" ], "products": [ "species_10599216" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10611068": { "compartment": "compartment_70101", "id": "reaction_10611068", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611065", "species_1497805" ], "products": [ "species_10611063", "species_198816" ], "modifiers": [ [ "species_10611065", "catalyst" ] ], "additional_components": [ "Q93315", "WBGene00007848", "species_71185", "Q93315", "WBGene00007848", "CHEBI:36144", "Q93315", "WBGene00007848", "species_71185" ] }, "reaction_10611568": { "compartment": "compartment_7660", "id": "reaction_10611568", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10611565", "catalyst" ] ], "additional_components": [ "species_216667", "P91851", "WBGene00009176" ] }, "reaction_10599221": { "compartment": "compartment_5460", "id": "reaction_10599221", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10599216", "catalyst" ] ], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297" ] }, "reaction_10610789": { "compartment": "compartment_70101", "id": "reaction_10610789", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10638379": { "compartment": "compartment_70101", "id": "reaction_10638379", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3000241" ], "products": [ "species_29366", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10626242": { "compartment": "compartment_70101", "id": "reaction_10626242", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638503": { "compartment": "compartment_70101", "id": "reaction_10638503", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10638374", "species_3149505" ], "products": [ "species_29366", "species_1130611", "species_10638376" ], "modifiers": [ [ "species_10638374", "catalyst" ] ], "additional_components": [ "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "WBGene00022766" ] }, "reaction_10630701": { "compartment": "compartment_70101", "id": "reaction_10630701", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10630689", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_10630699", "inhibitor" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10638549": { "compartment": "compartment_70101", "id": "reaction_10638549", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10638546", "catalyst" ], [ "species_29386", "inhibitor" ], [ "species_73524", "inhibitor" ] ], "additional_components": [ "Q3LFN0", "WBGene00044637", "G4SDH4", "WBGene00021626" ] }, "reaction_10626228": { "compartment": "compartment_70101", "id": "reaction_10626228", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10611047": { "compartment": "compartment_70101", "id": "reaction_10611047", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "O45352", "WBGene00001792", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "D7SFI3", "WBGene00043097", "P34277", "WBGene00015337" ] }, "reaction_10638491": { "compartment": "compartment_70101", "id": "reaction_10638491", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638483", "species_10638376" ], "products": [ "species_10638485" ], "modifiers": [], "additional_components": [ "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766" ] }, "reaction_10639602": { "compartment": "compartment_70101", "id": "reaction_10639602", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639600" ], "products": [ "species_10638369" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "P34385", "WBGene00303021", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "species_266099", "O45430", "WBGene00009319" ] }, "reaction_10610846": { "compartment": "compartment_70101", "id": "reaction_10610846", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10610843", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10659491": { "compartment": "compartment_876", "id": "reaction_10659491", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10659488", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10611255": { "compartment": "compartment_876", "id": "reaction_10611255", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10611252", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q22931", "WBGene00044738", "Q17766", "WBGene00007388" ] }, "reaction_10626163": { "compartment": "compartment_70101", "id": "reaction_10626163", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10626160", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10610799": { "compartment": "compartment_70101", "id": "reaction_10610799", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_29356" ], "products": [ "species_196931", "species_29372" ], "modifiers": [ [ "species_10610796", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10610771": { "compartment": "compartment_70101", "id": "reaction_10610771", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10610768", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_109496" ] }, "reaction_10662637": { "compartment": "compartment_5460", "id": "reaction_10662637", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113593" ], "products": [ "species_113563", "species_113581", "species_113529" ], "modifiers": [ [ "species_10662634", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10626240": { "compartment": "compartment_70101", "id": "reaction_10626240", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10626237", "catalyst" ] ], "additional_components": [ "Q20939", "WBGene00018996", "species_73524" ] }, "reaction_10638489": { "compartment": "compartment_70101", "id": "reaction_10638489", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149479", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10626226": { "compartment": "compartment_70101", "id": "reaction_10626226", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10617657": { "compartment": "compartment_17951", "id": "reaction_10617657", "reactome": "R-CEL-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10617654", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10611561": { "compartment": "compartment_5460", "id": "reaction_10611561", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10611558", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10611139": { "compartment": "compartment_70101", "id": "reaction_10611139", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10611131" ], "products": [ "species_10602960", "species_158466" ], "modifiers": [ [ "species_10611136", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10630715": { "compartment": "compartment_70101", "id": "reaction_10630715", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10630712", "catalyst" ] ], "additional_components": [ "species_216667", "O02058", "WBGene00015010" ] }, "reaction_10638168": { "compartment": "compartment_70101", "id": "reaction_10638168", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10638154" ], "products": [ "species_10638160", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10638207": { "compartment": "compartment_70101", "id": "reaction_10638207", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638200", "species_113592" ], "products": [ "species_10638205", "species_111294", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10626116": { "compartment": "compartment_70101", "id": "reaction_10626116", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10626113", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10638508": { "compartment": "compartment_70101", "id": "reaction_10638508", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638485" ], "products": [ "species_3149564", "species_10638487" ], "modifiers": [], "additional_components": [ "Q9XWC9", "WBGene00013577", "species_3149479", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766" ] }, "reaction_10620516": { "compartment": "compartment_876", "id": "reaction_10620516", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_429739" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "species_8869604", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "species_197230", "species_427486", "CHEBI:30772", "species_113557", "CHEBI:30768", "species_6807616", "WBGene00014092" ] }, "reaction_10610761": { "compartment": "compartment_70101", "id": "reaction_10610761", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10610758", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10638576": { "compartment": "compartment_70101", "id": "reaction_10638576", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10638573", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "O61198", "WBGene00017487", "O17892", "WBGene00010083", "Q960A1", "WBGene00015057", "CHEBI:44074", "species_113596" ] }, "reaction_10611119": { "compartment": "compartment_876", "id": "reaction_10611119", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_198836" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10611116", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "G8JZM6", "WBGene00021994", "O18057", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q9TYX7", "WBGene00021994", "Q18771", "WBGene00021994" ] }, "reaction_10641004": { "compartment": "compartment_70101", "id": "reaction_10641004", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10641002", "species_113592" ], "products": [ "species_111294", "species_10611528", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10626139": { "compartment": "compartment_70101", "id": "reaction_10626139", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10626123" ], "products": [ "species_10626128", "species_29432" ], "modifiers": [ [ "species_10626136", "catalyst" ] ], "additional_components": [ "species_216667", "O44510", "WBGene00018357", "species_216667", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10638578": { "compartment": "compartment_70101", "id": "reaction_10638578", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3149479", "species_10638495" ], "products": [ "species_10638497" ], "modifiers": [], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_3149479", "species_73524", "Q09582", "WBGene00010988", "species_113596" ] }, "reaction_10626230": { "compartment": "compartment_70101", "id": "reaction_10626230", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10626223", "catalyst" ] ], "additional_components": [ "species_216667", "O01824", "WBGene00019008" ] }, "reaction_10638518": { "compartment": "compartment_5460", "id": "reaction_10638518", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10638515", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10638506": { "compartment": "compartment_70101", "id": "reaction_10638506", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608124", "species_200665" ], "products": [ "species_10608120", "species_111355" ], "modifiers": [ [ "species_10608124", "catalyst" ] ], "additional_components": [ "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260", "Q17574", "WBGene00006510", "species_216667", "CHEBI:28115", "species_73524", "Q09582", "WBGene00010988", "species_113596", "Q17574", "WBGene00006510", "species_216667", "species_73524", "Q09582", "WBGene00010988", "species_113596", "species_3159260" ] }, "reaction_10626151": { "compartment": "compartment_70101", "id": "reaction_10626151", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10626148", "catalyst" ] ], "additional_components": [ "G5EGH2", "WBGene00003384", "species_109496" ] }, "reaction_10638382": { "compartment": "compartment_70101", "id": "reaction_10638382", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10638196": { "compartment": "compartment_70101", "id": "reaction_10638196", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10638190", "species_113592" ], "products": [ "species_111294", "species_10638194", "species_76577" ], "modifiers": [ [ "species_10638165", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10661102": { "compartment": "compartment_70101", "id": "reaction_10661102", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10610833", "catalyst" ] ], "additional_components": [ "Q9XXM2", "WBGene00012295", "P91851", "WBGene00009176", "species_109496" ] }, "reaction_10644423": { "compartment": "compartment_70101", "id": "reaction_10644423", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10644420", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669", "O45422", "WBGene00006687", "P90863", "WBGene00006682", "Q22042", "WBGene00006674", "Q19907", "WBGene00006667", "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318", "Q9BL31", "WBGene00006695", "Q21467", "WBGene00006679", "Q8IG65", "WBGene00006689", "Q65XY3", "WBGene00019904", "O45891", "WBGene00006692", "I2HAD3", "WBGene00006676", "A0A2X0RDZ3", "WBGene00006657", "Q19525", "WBGene00006661", "Q23297", "WBGene00006663", "H2KZ66", "WBGene00006666", "Q23435", "WBGene00006664", "O44773", "WBGene00018002", "Q6BES3", "WBGene00006677", "Q21529", "WBGene00006658", "Q22043", "WBGene00006675", "Q22940", "WBGene00006680", "Q9XTV6", "WBGene00006688", "O76791", "WBGene00006671", "G5EEH1", "WBGene00006693", "A1EHR5", "WBGene00006690", "U4PFA8", "WBGene00006656", "Q93732", "WBGene00006681", "Q5FC72", "WBGene00006660", "Q22271", "WBGene00006792", "H2L2J8", "WBGene00006691", "G5EG92", "WBGene00006678", "B0M0M8", "WBGene00006668", "G5EGD4", "WBGene00006686", "O45894", "WBGene00006685", "Q6EUT8", "WBGene00006683", "P34410", "WBGene00006662", "C0Z3L1", "WBGene00001190", "Q93764", "WBGene00006684", "A0A0K3AXZ4", "WBGene00006665", "Q9NEV3", "WBGene00006696", "Q23386", "WBGene00006659", "G5ED42", "WBGene00006670", "G5EBQ2", "WBGene00006694", "Q7YWY7", "WBGene00010784" ] }, "reaction_10660839": { "compartment": "compartment_7660", "id": "reaction_10660839", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660834", "species_77087" ], "products": [ "species_10660836", "species_77502" ], "modifiers": [ [ "species_10660834", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10661819": { "compartment": "compartment_7660", "id": "reaction_10661819", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10661812" ], "products": [ "species_10661816", "species_427486", "species_10661749" ], "modifiers": [ [ "species_10661812", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660958": { "compartment": "compartment_7660", "id": "reaction_10660958", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638691", "species_10658637" ], "products": [ "species_10660956" ], "modifiers": [], "additional_components": [ "Q09646", "WBGene00044072", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q09646", "WBGene00044072", "Q95ZL9", "WBGene00000272", "G5EF53", "WBGene00004204", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "J7SA49", "WBGene00002717", "Q9N4N4", "WBGene00022774", "P91094", "WBGene00004106", "G5EFQ5", "WBGene00004393", "G5EEY5", "WBGene00007042", "Q09441", "WBGene00007433", "Q9BL39", "WBGene00022182", "O02101", "WBGene00015971" ] }, "reaction_10663484": { "compartment": "compartment_7660", "id": "reaction_10663484", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_29358" ], "products": [ "species_113582", "species_10663429" ], "modifiers": [ [ "species_10607621", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10660771": { "compartment": "compartment_7660", "id": "reaction_10660771", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638603", "species_10658637" ], "products": [ "species_10660760" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661041": { "compartment": "compartment_7660", "id": "reaction_10661041", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661037", "species_10658637" ], "products": [ "species_10661039" ], "modifiers": [], "additional_components": [ "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q21263", "WBGene00003938", "G5ED14", "WBGene00001204", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660769": { "compartment": "compartment_7660", "id": "reaction_10660769", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660760", "species_77087" ], "products": [ "species_10660766", "species_77502" ], "modifiers": [ [ "species_10660760", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766" ] }, "reaction_10661097": { "compartment": "compartment_7660", "id": "reaction_10661097", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661087", "species_10597874" ], "products": [ "species_10661092", "species_10597899" ], "modifiers": [ [ "species_10661087", "catalyst" ] ], "additional_components": [ "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "WBGene00004393", "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10660861": { "compartment": "compartment_7660", "id": "reaction_10660861", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660856", "species_77087" ], "products": [ "species_10660858", "species_77502" ], "modifiers": [ [ "species_10660856", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10663499": { "compartment": "compartment_70101", "id": "reaction_10663499", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10663486", "species_10627446" ], "products": [ "species_10663490" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10660823": { "compartment": "compartment_7660", "id": "reaction_10660823", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660807", "species_77087" ], "products": [ "species_77502", "species_10660820" ], "modifiers": [ [ "species_10660807", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661089": { "compartment": "compartment_7660", "id": "reaction_10661089", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597899", "species_10660379" ], "products": [ "species_10661087" ], "modifiers": [], "additional_components": [ "Q6A590", "WBGene00020884", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00004393", "Q6A590", "WBGene00020884", "G5EFQ5", "WBGene00004393", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320" ] }, "reaction_10661731": { "compartment": "compartment_7660", "id": "reaction_10661731", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658643", "species_10628901" ], "products": [ "species_10661729" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661099": { "compartment": "compartment_7660", "id": "reaction_10661099", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661092" ], "products": [ "species_10597874" ], "modifiers": [ [ "species_10609534", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10664948": { "compartment": "compartment_7660", "id": "reaction_10664948", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611175", "species_10648260" ], "products": [ "species_10664946" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00006446", "O17850", "WBGene00006446", "O16850", "WBGene00000912" ] }, "reaction_10660832": { "compartment": "compartment_7660", "id": "reaction_10660832", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660827", "species_77087" ], "products": [ "species_10660829", "species_77502" ], "modifiers": [ [ "species_10660827", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10635481": { "compartment": "compartment_7660", "id": "reaction_10635481", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635477" ], "products": [ "species_10635479" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10663497": { "compartment": "compartment_70101", "id": "reaction_10663497", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10663490" ], "products": [ "species_10663492", "species_10627446" ], "modifiers": [ [ "species_10663490", "catalyst" ] ], "additional_components": [ "WBGene00006727", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659819": { "compartment": "compartment_7660", "id": "reaction_10659819", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10635483" ], "products": [ "species_10659817" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10635592": { "compartment": "compartment_7660", "id": "reaction_10635592", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635588", "species_10635496", "species_10635468" ], "products": [ "species_10635590" ], "modifiers": [], "additional_components": [ "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546", "WBGene00021636", "WBGene00008748", "Q8TA81", "WBGene00022695", "Q1T6W8", "WBGene00044798", "Q20257", "WBGene00006547", "O45291", "WBGene00006552", "Q9NA55", "WBGene00006559", "O02073", "WBGene00004750", "Q9N2K7", "WBGene00006549", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q09376", "WBGene00006554", "O61764", "WBGene00006551", "Q9N3S7", "WBGene00021636", "Q95PX3", "WBGene00006544", "Q9XVD5", "WBGene00006557", "Q23622", "WBGene00006555", "Q9U2C9", "WBGene00006556", "Q22292", "WBGene00006545", "Q19404", "WBGene00008748", "Q9TZL0", "WBGene00006550", "Q22289", "WBGene00006546" ] }, "reaction_10660962": { "compartment": "compartment_7660", "id": "reaction_10660962", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10658637" ], "products": [ "species_10660960" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664997": { "compartment": "compartment_7660", "id": "reaction_10664997", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10611173" ], "products": [ "species_2485002", "species_10664992" ], "modifiers": [ [ "species_10664994", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366" ] }, "reaction_10664901": { "compartment": "compartment_70101", "id": "reaction_10664901", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664897", "species_10614198" ], "products": [ "species_10664899" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10660805": { "compartment": "compartment_7660", "id": "reaction_10660805", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660796", "species_77087" ], "products": [ "species_10660802", "species_77502" ], "modifiers": [ [ "species_10660796", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10660877": { "compartment": "compartment_7660", "id": "reaction_10660877", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660872", "species_77087" ], "products": [ "species_10660874", "species_77502" ], "modifiers": [ [ "species_10660872", "catalyst" ] ], "additional_components": [ "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "G5EGI1", "WBGene00011729", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "P04255", "WBGene00001885", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q9N3S7", "WBGene00021636", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10661", "WBGene00001088", "Q17963", "WBGene00006474", "Q27894", "WBGene00001878", "P34545", "WBGene00000366", "Q27484", "WBGene00001915", "G5EGI1", "WBGene00011729", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q18221", "WBGene00004782", "Q9U2X0", "WBGene00013766", "P28515", "WBGene00001249", "P04255", "WBGene00001885", "G5EFZ3", "WBGene00012458", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q9N3S7", "WBGene00021636", "Q27876", "WBGene00001922", "Q09309", "WBGene00017683", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "G5EFQ5", "WBGene00004393", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q10661", "WBGene00001088" ] }, "reaction_10635491": { "compartment": "compartment_7660", "id": "reaction_10635491", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635468", "species_10635477" ], "products": [ "species_10635489" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660884": { "compartment": "compartment_7660", "id": "reaction_10660884", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660879", "species_77087" ], "products": [ "species_10660881", "species_77502" ], "modifiers": [ [ "species_10660879", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10663445": { "compartment": "compartment_7660", "id": "reaction_10663445", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10663437" ], "products": [ "species_10660385", "species_113541" ], "modifiers": [ [ "species_10663442", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00021856" ] }, "reaction_10660389": { "compartment": "compartment_7660", "id": "reaction_10660389", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660385", "species_10660383" ], "products": [ "species_10660387" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "Q95ZL9", "WBGene00000272", "P45896", "WBGene00004857", "G5EFQ5", "WBGene00004393", "Q02330", "WBGene00004856", "P45897", "WBGene00004858" ] }, "reaction_10664907": { "compartment": "compartment_70101", "id": "reaction_10664907", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664903", "species_10664881" ], "products": [ "species_10664905" ], "modifiers": [], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10665000": { "compartment": "compartment_7660", "id": "reaction_10665000", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664992", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10611173" ], "modifiers": [ [ "species_10619855", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10664952": { "compartment": "compartment_7660", "id": "reaction_10664952", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10607873" ], "products": [ "species_10664950" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10660426": { "compartment": "compartment_7660", "id": "reaction_10660426", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10658637" ], "products": [ "species_113582", "species_10660419" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10661025": { "compartment": "compartment_7660", "id": "reaction_10661025", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661021", "species_10658637" ], "products": [ "species_10661023" ], "modifiers": [], "additional_components": [ "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O01521", "WBGene00017598", "H2KYY1", "WBGene00016029", "O01519", "WBGene00017601", "G5EFQ5", "WBGene00004393" ] }, "reaction_10664911": { "compartment": "compartment_70101", "id": "reaction_10664911", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664883", "species_10621567" ], "products": [ "species_10664909" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10659823": { "compartment": "compartment_7660", "id": "reaction_10659823", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635487", "species_10629366" ], "products": [ "species_10659821" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660224": { "compartment": "compartment_7660", "id": "reaction_10660224", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660220", "species_10658637" ], "products": [ "species_10660222" ], "modifiers": [], "additional_components": [ "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q86MF0", "WBGene00001439", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661755": { "compartment": "compartment_7660", "id": "reaction_10661755", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661739", "species_10661749" ], "products": [ "species_10661751" ], "modifiers": [ [ "species_10661753", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95Y80", "WBGene00022473", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10662820": { "compartment": "compartment_7660", "id": "reaction_10662820", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10629366" ], "products": [ "species_113582", "species_10662817" ], "modifiers": [ [ "species_10648106", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10664885": { "compartment": "compartment_7660", "id": "reaction_10664885", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611182" ], "products": [ "species_10614198" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10660424": { "compartment": "compartment_7660", "id": "reaction_10660424", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660408", "species_29358" ], "products": [ "species_113582", "species_10660421" ], "modifiers": [ [ "species_10640977", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10660428": { "compartment": "compartment_7660", "id": "reaction_10660428", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628901", "species_10658637" ], "products": [ "species_10660408" ], "modifiers": [], "additional_components": [ "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10659827": { "compartment": "compartment_7660", "id": "reaction_10659827", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635485", "species_10629366" ], "products": [ "species_10659825" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10660868": { "compartment": "compartment_7660", "id": "reaction_10660868", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660863", "species_77087" ], "products": [ "species_10660865", "species_77502" ], "modifiers": [ [ "species_10660863", "catalyst" ] ], "additional_components": [ "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "O17695", "WBGene00001834", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P04255", "WBGene00001885", "Q95ZL9", "WBGene00000272", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "A5JYW9", "WBGene00004117", "Q23429", "WBGene00014240", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875" ] }, "reaction_10661814": { "compartment": "compartment_7660", "id": "reaction_10661814", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661810", "species_10641328" ], "products": [ "species_10661812" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393", "WBGene00001837", "Q95ZL9", "WBGene00000272", "O17323", "WBGene00001837", "Q95Y80", "WBGene00022473", "G5EFQ5", "WBGene00004393" ] }, "reaction_10661742": { "compartment": "compartment_7660", "id": "reaction_10661742", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661729", "species_113560" ], "products": [ "species_2485002", "species_10661739" ], "modifiers": [ [ "species_10661729", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393" ] }, "reaction_10662813": { "compartment": "compartment_7660", "id": "reaction_10662813", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10629366", "species_10658637" ], "products": [ "species_10662811" ], "modifiers": [ [ "species_10648106", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10657931": { "compartment": "compartment_7660", "id": "reaction_10657931", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657923", "species_10657927" ], "products": [ "species_10657929", "species_10611936" ], "modifiers": [], "additional_components": [ "WBGene00006380", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380", "Q10666", "WBGene00004077", "WBGene00001979" ] }, "reaction_10665048": { "compartment": "compartment_7660", "id": "reaction_10665048", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611171", "species_10628899" ], "products": [ "species_10665046" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000366", "P34545", "WBGene00000366", "O16850", "WBGene00000912" ] }, "reaction_10644162": { "compartment": "compartment_7660", "id": "reaction_10644162", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10643385", "species_10643390" ], "products": [ "species_10643405" ], "modifiers": [], "additional_components": [ "WBGene00003418", "WBGene00003422", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10644164": { "compartment": "compartment_7660", "id": "reaction_10644164", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643378", "species_10643373" ], "products": [ "species_10643380" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373" ] }, "reaction_10643409": { "compartment": "compartment_7660", "id": "reaction_10643409", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358514", "species_10643405" ], "products": [ "species_10643407" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643422": { "compartment": "compartment_7660", "id": "reaction_10643422", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10643407" ], "products": [ "species_113582", "species_10643394" ], "modifiers": [], "additional_components": [ "Q9N3T8", "WBGene00003422", "species_29370", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643398": { "compartment": "compartment_7660", "id": "reaction_10643398", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643380", "species_10598196", "species_10643394" ], "products": [ "species_10643396" ], "modifiers": [], "additional_components": [ "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "O02115", "WBGene00003955", "Q9N3T8", "WBGene00003422", "species_113592", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643420": { "compartment": "compartment_7660", "id": "reaction_10643420", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643416", "species_10643400" ], "products": [ "species_10643418" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O62245", "WBGene00009731", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10643403": { "compartment": "compartment_7660", "id": "reaction_10643403", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643396" ], "products": [ "species_10643400" ], "modifiers": [ [ "species_10643396", "catalyst" ] ], "additional_components": [ "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "O02115", "WBGene00003955", "species_113592", "G5EFG5", "WBGene00004064", "Q9XU10", "WBGene00003373", "Q9TXR4", "WBGene00003418" ] }, "reaction_10618428": { "compartment": "compartment_70101", "id": "reaction_10618428", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618374" ], "products": [ "species_29370", "species_10618425" ], "modifiers": [ [ "species_10618374", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111" ] }, "reaction_10618502": { "compartment": "compartment_70101", "id": "reaction_10618502", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618425", "species_113592" ], "products": [ "species_29370", "species_10618499" ], "modifiers": [ [ "species_10610641", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5ECH7", "WBGene00000407", "O45657", "WBGene00004048", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22695", "WBGene00011955", "Q95XP4", "WBGene00003111", "Q18677", "WBGene00000964", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "Q9U2Q9", "WBGene00001746" ] }, "reaction_10618464": { "compartment": "compartment_70101", "id": "reaction_10618464", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618352", "species_113592", "species_10618238" ], "products": [ "species_29370", "species_10618461" ], "modifiers": [ [ "species_10613594", "catalyst" ] ], "additional_components": [ "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q01630", "WBGene00006769", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q21773", "WBGene00000963", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "Q18677", "WBGene00000964", "Q22243", "WBGene00022780", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "G5EC46", "WBGene00002193", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "O02064", "WBGene00022780" ] }, "reaction_10599289": { "compartment": "compartment_70101", "id": "reaction_10599289", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10599286", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10599309": { "compartment": "compartment_70101", "id": "reaction_10599309", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10599306", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10599299": { "compartment": "compartment_70101", "id": "reaction_10599299", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10599296", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10625266": { "compartment": "compartment_70101", "id": "reaction_10625266", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10639641": { "compartment": "compartment_70101", "id": "reaction_10639641", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10639638", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10639334": { "compartment": "compartment_5460", "id": "reaction_10639334", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10639331", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10639365": { "compartment": "compartment_984", "id": "reaction_10639365", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10639362", "catalyst" ] ], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10649479": { "compartment": "compartment_5460", "id": "reaction_10649479", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_113573", "species_5696194" ], "modifiers": [ [ "species_10649476", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10639564": { "compartment": "compartment_5460", "id": "reaction_10639564", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10639549" ], "products": [ "species_10639552", "species_113521" ], "modifiers": [ [ "species_10639561", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10639577": { "compartment": "compartment_5460", "id": "reaction_10639577", "reactome": "R-CEL-3323013", "name": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_1655887" ], "products": [ "species_1655882", "species_113521" ], "modifiers": [ [ "species_10639574", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10639589": { "compartment": "compartment_5460", "id": "reaction_10639589", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_10639552", "species_113529" ], "products": [ "species_113563", "species_10639549" ], "modifiers": [ [ "species_10639586", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10639598": { "compartment": "compartment_5460", "id": "reaction_10639598", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10639595", "catalyst" ] ], "additional_components": [ "species_113596", "Q93379", "WBGene00008117" ] }, "reaction_10640254": { "compartment": "compartment_17927", "id": "reaction_10640254", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10640251", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639375": { "compartment": "compartment_70101", "id": "reaction_10639375", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10639372", "catalyst" ] ], "additional_components": [ "species_216667", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10639607": { "compartment": "compartment_70616", "id": "reaction_10639607", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10606530" ], "products": [ "species_10606528", "species_189461" ], "modifiers": [], "additional_components": [ "Q23240", "WBGene00013854", "CHEBI:38574", "P19974", "WBGene00017121", "CHEBI:38573", "Q23240", "WBGene00013854", "P19974", "WBGene00017121" ] }, "reaction_10603119": { "compartment": "compartment_17951", "id": "reaction_10603119", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10603116", "catalyst" ] ], "additional_components": [ "species_71185", "Q8MYL7", "WBGene00013220", "species_113601" ] }, "reaction_10641727": { "compartment": "compartment_17963", "id": "reaction_10641727", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641725" ], "products": [ "species_10639362" ], "modifiers": [], "additional_components": [ "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901", "species_216667", "Q27538", "WBGene00007036", "P34461", "WBGene00004933", "P34697", "WBGene00004930", "species_936901" ] }, "reaction_10599744": { "compartment": "compartment_70101", "id": "reaction_10599744", "reactome": "R-CEL-71676", "name": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10599741", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "Q93204", "WBGene00007516" ] }, "reaction_10649557": { "compartment": "compartment_7660", "id": "reaction_10649557", "reactome": "R-CEL-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10649551" ], "products": [ "species_10649553" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10649555": { "compartment": "compartment_7660", "id": "reaction_10649555", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10649553" ], "products": [ "species_427497", "species_10648323" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727" ] }, "reaction_10648696": { "compartment": "compartment_7660", "id": "reaction_10648696", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641259", "species_10641290", "species_10648255" ], "products": [ "species_10648694" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "WBGene00022296", "WBGene00013924", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10649835": { "compartment": "compartment_7660", "id": "reaction_10649835", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648742", "species_10597874" ], "products": [ "species_10649551" ], "modifiers": [ [ "species_10648742", "catalyst" ] ], "additional_components": [ "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648744": { "compartment": "compartment_7660", "id": "reaction_10648744", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10648740", "species_10648694" ], "products": [ "species_10648738", "species_10648742" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q23457", "WBGene00004320", "P30644", "WBGene00015264", "Q11083", "WBGene00015264", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10633715": { "compartment": "compartment_12045", "id": "reaction_10633715", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10633712", "catalyst" ] ], "additional_components": [ "Q19056", "WBGene00020256", "O17405", "WBGene00017316", "Q21754", "WBGene00004039", "species_74016", "H2KZ05", "WBGene00020256", "Q8I4C7", "WBGene00020256" ] }, "reaction_10633605": { "compartment": "compartment_70101", "id": "reaction_10633605", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633602", "catalyst" ] ], "additional_components": [ "Q21754", "WBGene00004039", "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10633496": { "compartment": "compartment_70101", "id": "reaction_10633496", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10633493", "catalyst" ] ], "additional_components": [ "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q95Q62", "WBGene00002979", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10633721": { "compartment": "compartment_70101", "id": "reaction_10633721", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633745": { "compartment": "compartment_876", "id": "reaction_10633745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10633742", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q21754", "WBGene00004039", "species_74016", "G5EFI8", "WBGene00004036" ] }, "reaction_10633663": { "compartment": "compartment_70101", "id": "reaction_10633663", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10633660", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "species_109496" ] }, "reaction_10633682": { "compartment": "compartment_876", "id": "reaction_10633682", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10633677", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10615561": { "compartment": "compartment_70101", "id": "reaction_10615561", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10615546" ], "products": [ "species_29370", "species_10615558" ], "modifiers": [ [ "species_10615546", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "P24348", "WBGene00002299" ] }, "reaction_10615698": { "compartment": "compartment_70101", "id": "reaction_10615698", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615694", "species_10615689" ], "products": [ "species_10615696" ], "modifiers": [], "additional_components": [ "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q9XWK4", "WBGene00013202" ] }, "reaction_10615677": { "compartment": "compartment_70101", "id": "reaction_10615677", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615453", "species_10615673" ], "products": [ "species_10615675" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00021369", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10658154": { "compartment": "compartment_70101", "id": "reaction_10658154", "reactome": "R-CEL-8855237", "name": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658145" ], "products": [ "species_29370", "species_10658152" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "Q7JP80", "WBGene00020481", "Q6A573", "WBGene00021549", "A0A486WXX8", "WBGene00000894", "WBGene00005077" ] }, "reaction_10618622": { "compartment": "compartment_70101", "id": "reaction_10618622", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618613", "species_10618615" ], "products": [ "species_10618617" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10615963": { "compartment": "compartment_984", "id": "reaction_10615963", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_10615959" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "WBGene00004372", "P17139", "WBGene00001263", "C6KRM7", "WBGene00004372", "P17139", "WBGene00001263" ] }, "reaction_10618620": { "compartment": "compartment_70101", "id": "reaction_10618620", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618611" ], "products": [ "species_10605408", "species_29420" ], "modifiers": [ [ "species_10618617", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_111349", "Q22038", "WBGene00004357", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "G5EFE1", "WBGene00006468", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "P24348", "WBGene00002299", "H2L0P5", "WBGene00022391" ] }, "reaction_10663513": { "compartment": "compartment_984", "id": "reaction_10663513", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616067", "species_2299699" ], "products": [ "species_10663511" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10618951": { "compartment": "compartment_70101", "id": "reaction_10618951", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615741", "species_10615184" ], "products": [ "species_10615743" ], "modifiers": [], "additional_components": [ "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "WBGene00005077", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615457": { "compartment": "compartment_876", "id": "reaction_10615457", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615453" ], "products": [ "species_10615455" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618943": { "compartment": "compartment_70101", "id": "reaction_10618943", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618938", "species_10617638" ], "products": [ "species_10618940", "species_29420" ], "modifiers": [ [ "species_10618938", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_29420", "Q05062", "WBGene00000390", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615459": { "compartment": "compartment_984", "id": "reaction_10615459", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615451", "species_10615440" ], "products": [ "species_10615453" ], "modifiers": [], "additional_components": [ "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10624235": { "compartment": "compartment_876", "id": "reaction_10624235", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231", "species_10624224" ], "products": [ "species_10624233" ], "modifiers": [], "additional_components": [ "Q26261", "WBGene00006745", "G5EF96", "unc-40", "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "unc-40", "O44565", "WBGene00002247" ] }, "reaction_10618294": { "compartment": "compartment_70101", "id": "reaction_10618294", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618273", "species_10618290" ], "products": [ "species_10618292", "species_10615191" ], "modifiers": [], "additional_components": [ "WBGene00001490", "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10618595": { "compartment": "compartment_70101", "id": "reaction_10618595", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618584" ], "products": [ "species_29372", "species_10618586" ], "modifiers": [ [ "species_10618592", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "G5EBK8", "WBGene00004310", "species_111349", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10616046": { "compartment": "compartment_70101", "id": "reaction_10616046", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616020", "species_10616042" ], "products": [ "species_10616044" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03206", "ced-10", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618605": { "compartment": "compartment_70101", "id": "reaction_10618605", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605408", "species_29356" ], "products": [ "species_10605406", "species_29372" ], "modifiers": [ [ "species_10618602", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "species_29420", "Q22038", "WBGene00004357", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10618949": { "compartment": "compartment_70101", "id": "reaction_10618949", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618936", "species_10615485" ], "products": [ "species_10618938" ], "modifiers": [], "additional_components": [ "WBGene00000419", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618564": { "compartment": "compartment_70101", "id": "reaction_10618564", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618560", "species_10605399" ], "products": [ "species_10618562" ], "modifiers": [], "additional_components": [ "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "Q03206", "ced-10", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q03206", "ced-10", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "species_29438", "Q95XP4", "WBGene00003111" ] }, "reaction_10618025": { "compartment": "compartment_70101", "id": "reaction_10618025", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10618020", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10615659": { "compartment": "compartment_876", "id": "reaction_10615659", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440", "species_10615655" ], "products": [ "species_10615657" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "unc-40", "species_179856" ] }, "reaction_10616034": { "compartment": "compartment_876", "id": "reaction_10616034", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616030" ], "products": [ "species_10616032" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10615967": { "compartment": "compartment_984", "id": "reaction_10615967", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615729", "species_114570" ], "products": [ "species_10615965" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_113592" ] }, "reaction_10618022": { "compartment": "compartment_70101", "id": "reaction_10618022", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10618014" ], "products": [ "species_10618020" ], "modifiers": [], "additional_components": [ "WBGene00004947", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "Q9N5D3", "WBGene00004947", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618016": { "compartment": "compartment_70101", "id": "reaction_10618016", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602400", "species_10618010" ], "products": [ "species_10618014" ], "modifiers": [], "additional_components": [ "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "P29355", "WBGene00004774", "G5EE56", "WBGene00005077", "C6KRM7", "WBGene00004372", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10618955": { "compartment": "compartment_70101", "id": "reaction_10618955", "reactome": "R-CEL-418874", "name": "Recruitment and activation of N-WASP by Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618940", "species_10612328", "species_179856" ], "products": [ "species_10618953" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "O62422", "WBGene00012532", "WBGene00007840", "G5EE56", "WBGene00005077", "Q05062", "WBGene00000390", "Q8I4M6", "WBGene00007840", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "species_29438", "G5EEN3", "WBGene00000419", "G5EF96", "unc-40", "P34710", "unc-6", "species_179856", "O62422", "WBGene00012532" ] }, "reaction_10663935": { "compartment": "compartment_984", "id": "reaction_10663935", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620230", "species_2299699" ], "products": [ "species_10663933" ], "modifiers": [], "additional_components": [ "species_2299699", "G5EF96", "unc-40" ] }, "reaction_10615746": { "compartment": "compartment_70101", "id": "reaction_10615746", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615743", "species_113592" ], "products": [ "species_29370", "species_10615483" ], "modifiers": [ [ "species_10615743", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615650": { "compartment": "compartment_70101", "id": "reaction_10615650", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615646", "species_179856" ], "products": [ "species_10615648" ], "modifiers": [], "additional_components": [ "WBGene00001333", "G5EBK3", "WBGene00001333", "species_179856" ] }, "reaction_10618996": { "compartment": "compartment_70101", "id": "reaction_10618996", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615530", "species_113592", "species_10618993" ], "products": [ "species_29370", "species_10618560" ], "modifiers": [ [ "species_10618993", "catalyst" ] ], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10618318": { "compartment": "compartment_70101", "id": "reaction_10618318", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618242", "species_113592" ], "products": [ "species_29370", "species_10618315" ], "modifiers": [ [ "species_10618242", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780" ] }, "reaction_10660741": { "compartment": "compartment_70101", "id": "reaction_10660741", "reactome": "R-CEL-8933328", "name": "LYPLA2 hydrolyses PALM-C3,4-GAP43", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660731", "species_29356" ], "products": [ "species_3632881", "species_10660733" ], "modifiers": [ [ "species_10660738", "catalyst" ] ], "additional_components": [ "WBGene00018214", "WBGene00018214", "WBGene00010564" ] }, "reaction_10622809": { "compartment": "compartment_70101", "id": "reaction_10622809", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10622806" ], "products": [ "species_29370", "species_10609588" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "species_109496", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618607": { "compartment": "compartment_70101", "id": "reaction_10618607", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618600", "species_10618592" ], "products": [ "species_10618602" ], "modifiers": [], "additional_components": [ "WBGene00010374", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "Q95XP4", "WBGene00003111", "species_29438", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "Q9XVQ7", "WBGene00008711", "O45611", "WBGene00010374", "Q95XP4", "WBGene00003111", "species_29438" ] }, "reaction_10615487": { "compartment": "compartment_70101", "id": "reaction_10615487", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615471", "species_10615483" ], "products": [ "species_10615485" ], "modifiers": [], "additional_components": [ "WBGene00006410", "G5EE56", "WBGene00005077", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6", "G5EE56", "WBGene00005077", "Q95PX0", "WBGene00006410", "Q95YD4", "WBGene00002213", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10615671": { "compartment": "compartment_70101", "id": "reaction_10615671", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615667", "species_10615453" ], "products": [ "species_10615669" ], "modifiers": [], "additional_components": [ "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6", "Q965X6", "WBGene00021369", "G5EF96", "unc-40", "P34710", "unc-6" ] }, "reaction_10618283": { "compartment": "compartment_876", "id": "reaction_10618283", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618208", "species_10618277" ], "products": [ "species_10618273", "species_10618281" ], "modifiers": [], "additional_components": [ "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "G5EE56", "WBGene00005077", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "O17905", "WBGene00001490", "WBGene00001490", "G5EE56", "WBGene00005077", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111" ] }, "reaction_10615500": { "compartment": "compartment_876", "id": "reaction_10615500", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615494", "species_10615496" ], "products": [ "species_10615498" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10615662": { "compartment": "compartment_70101", "id": "reaction_10615662", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10615648" ], "products": [ "species_29370", "species_10615655" ], "modifiers": [ [ "species_10612166", "catalyst" ] ], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "WBGene00006599" ] }, "reaction_10622784": { "compartment": "compartment_70101", "id": "reaction_10622784", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607317" ], "products": [ "species_29370", "species_10607331" ], "modifiers": [ [ "species_10616044", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "Q17850", "WBGene00003911", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "species_29438", "H2KZ60", "WBGene00016354" ] }, "reaction_10618244": { "compartment": "compartment_70101", "id": "reaction_10618244", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618240", "species_10617742" ], "products": [ "species_10618242", "species_10617744" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "G5EGQ3", "WBGene00003144", "Q22243", "WBGene00022780", "O45657", "WBGene00004048", "Q17850", "WBGene00003911", "H2KZ80", "WBGene00022780", "D6R8W4", "WBGene00002206", "Q19726", "WBGene00002198", "H8ESG3", "WBGene00022780", "Q23554", "WBGene00022780", "O01774", "WBGene00022780", "G5EBM6", "WBGene00002204", "P91360", "WBGene00022780", "Q18865", "WBGene00022780", "Q20933", "WBGene00022780", "Q9TXI2", "WBGene00022780", "U4PRY7", "WBGene00004047", "Q9GZG1", "WBGene00022780", "Q23102", "WBGene00022780", "Q03206", "ced-10", "Q9U3B5", "WBGene00022780", "Q21764", "WBGene00022780", "Q9U2T8", "WBGene00022780", "Q9N4S6", "WBGene00022780", "Q22146", "WBGene00001487", "species_29438", "G5EC46", "WBGene00002193", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q22765", "WBGene00022780", "Q19704", "WBGene00022780", "A0A0S4FT70", "WBGene00022780", "Q9TYX4", "WBGene00022780", "Q22245", "WBGene00002208", "Q18142", "WBGene00022780", "A0A061ADQ6", "WBGene00022780", "Q9XW34", "WBGene00022780", "Q95XP4", "WBGene00003111", "O02064", "WBGene00022780", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10612171": { "compartment": "compartment_876", "id": "reaction_10612171", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612161", "species_113592" ], "products": [ "species_29370", "species_10612168" ], "modifiers": [ [ "species_10612152", "catalyst" ] ], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599", "species_202247", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10603943": { "compartment": "compartment_5460", "id": "reaction_10603943", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77276" ], "products": [ "species_77269", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603937": { "compartment": "compartment_5460", "id": "reaction_10603937", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10603940": { "compartment": "compartment_5460", "id": "reaction_10603940", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10606622": { "compartment": "compartment_70101", "id": "reaction_10606622", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606632": { "compartment": "compartment_70101", "id": "reaction_10606632", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29878", "species_29790" ], "modifiers": [ [ "species_10599506", "catalyst" ] ], "additional_components": [ "species_8878387", "O17759", "WBGene00008506", "species_109496" ] }, "reaction_10606636": { "compartment": "compartment_70101", "id": "reaction_10606636", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10610356": { "compartment": "compartment_984", "id": "reaction_10610356", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10610351": { "compartment": "compartment_984", "id": "reaction_10610351", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_174602", "species_171149" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10662935": { "compartment": "compartment_984", "id": "reaction_10662935", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10662932", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10610354": { "compartment": "compartment_984", "id": "reaction_10610354", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_192438", "species_174602" ], "modifiers": [ [ "species_10610348", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "species_193451", "Q9XTG1", "WBGene00006412", "CHEBI:9407", "CHEBI:28865", "Q20826", "WBGene00018878", "CHEBI:36274" ] }, "reaction_10646460": { "compartment": "compartment_70101", "id": "reaction_10646460", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661262" ], "modifiers": [ [ "species_10646457", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10646450": { "compartment": "compartment_70101", "id": "reaction_10646450", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_29366", "species_5660033" ], "modifiers": [ [ "species_10646447", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10646471": { "compartment": "compartment_70101", "id": "reaction_10646471", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_73473", "species_5661281" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10646468": { "compartment": "compartment_70101", "id": "reaction_10646468", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661281", "species_113592" ], "products": [ "species_29370", "species_29790" ], "modifiers": [ [ "species_10646465", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10637289": { "compartment": "compartment_984", "id": "reaction_10637289", "reactome": "R-CEL-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_351629" ], "products": [ "species_10637270" ], "modifiers": [ [ "species_10637286", "catalyst" ] ], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "CHEBI:15858", "Q20616", "WBGene00009897" ] }, "reaction_10630811": { "compartment": "compartment_984", "id": "reaction_10630811", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630807" ], "products": [ "species_10630809" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636388": { "compartment": "compartment_984", "id": "reaction_10636388", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630809" ], "products": [ "species_10636386" ], "modifiers": [], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066" ] }, "reaction_10636390": { "compartment": "compartment_984", "id": "reaction_10636390", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631426" ], "products": [ "species_10631430" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "P17139", "WBGene00001263" ] }, "reaction_10648222": { "compartment": "compartment_5460", "id": "reaction_10648222", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598736", "species_113526" ], "products": [ "species_10648212", "species_5688274" ], "modifiers": [ [ "species_10648219", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "species_216667", "Q20480", "WBGene00004801" ] }, "reaction_10601562": { "compartment": "compartment_70101", "id": "reaction_10601562", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "products": [ "species_72617", "species_10601244", "species_10601197", "species_10601180", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "WBGene00019162", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10601250": { "compartment": "compartment_70101", "id": "reaction_10601250", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601239" ], "products": [ "species_29370", "species_29372", "species_10601239" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q9NEN6", "WBGene00004475", "Q94261", "WBGene00019543", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "P51403", "WBGene00004471", "O61955", "WBGene00002061", "O45499", "WBGene00004495", "Q95XR0", "WBGene00021466", "A0A486WX07", "WBGene00002066", "O18240", "WBGene00004487", "Q22054", "WBGene00004485", "O01692", "WBGene00004486", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "Q20206", "WBGene00004480", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "Q23312", "WBGene00004476", "species_29438", "Q95Y04", "WBGene00004497", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q18967", "WBGene00001229" ] }, "reaction_10666329": { "compartment": "compartment_12045", "id": "reaction_10666329", "reactome": "R-CEL-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10603316", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666306": { "compartment": "compartment_70101", "id": "reaction_10666306", "reactome": "R-CEL-9751201", "name": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635280", "species_9748947" ], "products": [ "species_10635280", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10666331": { "compartment": "compartment_70101", "id": "reaction_10666331", "reactome": "R-CEL-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10629173", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10666335": { "compartment": "compartment_70101", "id": "reaction_10666335", "reactome": "R-CEL-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10644157", "catalyst" ] ], "additional_components": [ "species_216667", "Q5WRS4", "WBGene00015509" ] }, "reaction_10666327": { "compartment": "compartment_70101", "id": "reaction_10666327", "reactome": "R-CEL-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10666324", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q9U2G5", "WBGene00003413", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411" ] }, "reaction_10636049": { "compartment": "compartment_70101", "id": "reaction_10636049", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10636046", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666268": { "compartment": "compartment_984", "id": "reaction_10666268", "reactome": "R-CEL-9749583", "name": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749786" ], "products": [ "species_9749576" ], "modifiers": [ [ "species_10624115", "catalyst" ] ], "additional_components": [ "species_9749790", "species_9749785", "species_9749790", "species_9749785", "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10666317": { "compartment": "compartment_70101", "id": "reaction_10666317", "reactome": "R-CEL-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10608242", "catalyst" ] ], "additional_components": [ "P10299", "WBGene00001749" ] }, "reaction_10666295": { "compartment": "compartment_70101", "id": "reaction_10666295", "reactome": "R-CEL-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10630663", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003411" ] }, "reaction_10666333": { "compartment": "compartment_876", "id": "reaction_10666333", "reactome": "R-CEL-9753634", "name": "GGT dimers hydrolyse APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753685", "species_29356" ], "products": [ "species_9753680", "species_29404" ], "modifiers": [ [ "species_10644147", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10666285": { "compartment": "compartment_17957", "id": "reaction_10666285", "reactome": "R-CEL-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666314": { "compartment": "compartment_70101", "id": "reaction_10666314", "reactome": "R-CEL-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10666252": { "compartment": "compartment_70101", "id": "reaction_10666252", "reactome": "R-CEL-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10636101": { "compartment": "compartment_70101", "id": "reaction_10636101", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10636104": { "compartment": "compartment_70101", "id": "reaction_10636104", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10599778", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10606291": { "compartment": "compartment_70101", "id": "reaction_10606291", "reactome": "R-CEL-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10606288", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10666322": { "compartment": "compartment_70101", "id": "reaction_10666322", "reactome": "R-CEL-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10666319", "catalyst" ] ], "additional_components": [ "species_158472", "species_158604", "CHEBI:32636", "species_158472", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412" ] }, "reaction_10666236": { "compartment": "compartment_70101", "id": "reaction_10666236", "reactome": "R-CEL-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10601884", "catalyst" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682" ] }, "reaction_10666250": { "compartment": "compartment_70101", "id": "reaction_10666250", "reactome": "R-CEL-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666257": { "compartment": "compartment_70101", "id": "reaction_10666257", "reactome": "R-CEL-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10623568", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10666289": { "compartment": "compartment_17957", "id": "reaction_10666289", "reactome": "R-CEL-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10664160", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10666302": { "compartment": "compartment_70101", "id": "reaction_10666302", "reactome": "R-CEL-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10604126", "catalyst" ] ], "additional_components": [ "WBGene00009499" ] }, "reaction_10666240": { "compartment": "compartment_70101", "id": "reaction_10666240", "reactome": "R-CEL-9748951", "name": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_9748998" ], "products": [ "species_9748992", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10666281": { "compartment": "compartment_17957", "id": "reaction_10666281", "reactome": "R-CEL-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10648942", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666304": { "compartment": "compartment_70101", "id": "reaction_10666304", "reactome": "R-CEL-9751037", "name": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015", "species_74113" ], "products": [ "species_83910", "species_9748998" ], "modifiers": [ [ "species_10604151", "catalyst" ] ], "additional_components": [ "WBGene00017867" ] }, "reaction_10666292": { "compartment": "compartment_70101", "id": "reaction_10666292", "reactome": "R-CEL-9750546", "name": "ABCC4 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750587", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750548", "species_29372" ], "modifiers": [ [ "species_10630658", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "pubchem.compound:3037883", "CHEBI:80613", "pubchem.compound:3037883", "CHEBI:2332", "WBGene00003412" ] }, "reaction_10666287": { "compartment": "compartment_5460", "id": "reaction_10666287", "reactome": "R-CEL-9750001", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749985", "species_159549" ], "products": [ "species_29374", "species_9750005" ], "modifiers": [ [ "species_10606398", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10666245": { "compartment": "compartment_70101", "id": "reaction_10666245", "reactome": "R-CEL-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10666242", "catalyst" ] ], "additional_components": [ "Q09580", "WBGene00010912" ] }, "reaction_10666247": { "compartment": "compartment_70101", "id": "reaction_10666247", "reactome": "R-CEL-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10666255": { "compartment": "compartment_70101", "id": "reaction_10666255", "reactome": "R-CEL-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10608198", "catalyst" ] ], "additional_components": [ "O45010", "WBGene00021127" ] }, "reaction_10666278": { "compartment": "compartment_984", "id": "reaction_10666278", "reactome": "R-CEL-9749609", "name": "BCHE hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9749598" ], "products": [ "species_1524044", "species_351626", "species_9749546" ], "modifiers": [ [ "species_10666275", "catalyst" ] ], "additional_components": [ "WBGene00000037" ] }, "reaction_10666273": { "compartment": "compartment_984", "id": "reaction_10666273", "reactome": "R-CEL-9749607", "name": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749598" ], "products": [ "species_9749785" ], "modifiers": [ [ "species_10666270", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10666311": { "compartment": "compartment_70101", "id": "reaction_10666311", "reactome": "R-CEL-9753277", "name": "SULT dimers sulfate APAP to APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_9677362" ], "products": [ "species_9753448", "species_158466" ], "modifiers": [ [ "species_10666308", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10666283": { "compartment": "compartment_17957", "id": "reaction_10666283", "reactome": "R-CEL-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10666300": { "compartment": "compartment_70101", "id": "reaction_10666300", "reactome": "R-CEL-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10666297", "catalyst" ] ], "additional_components": [ "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "species_159572", "species_9750014", "species_9750005", "CHEBI:176976", "species_9750011", "CHEBI:176960", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10636044": { "compartment": "compartment_70101", "id": "reaction_10636044", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161194", "species_29356" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10666238": { "compartment": "compartment_70101", "id": "reaction_10666238", "reactome": "R-CEL-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "WBGene00020190" ] }, "reaction_10661697": { "compartment": "compartment_70101", "id": "reaction_10661697", "reactome": "R-CEL-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10648618", "species_10661684" ], "products": [ "species_10661694", "species_111294", "species_76577" ], "modifiers": [ [ "species_10661684", "catalyst" ] ], "additional_components": [ "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341" ] }, "reaction_10601554": { "compartment": "compartment_70101", "id": "reaction_10601554", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601535", "species_10601180" ], "products": [ "species_10601180", "species_10601108", "species_10601533" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "WBGene00019162", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438" ] }, "reaction_10626992": { "compartment": "compartment_20699", "id": "reaction_10626992", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10626989", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10661677": { "compartment": "compartment_70101", "id": "reaction_10661677", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648620" ], "products": [ "species_10648618", "species_10648609" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "WBGene00003587", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721" ] }, "reaction_10657880": { "compartment": "compartment_70101", "id": "reaction_10657880", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10657877", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10606457": { "compartment": "compartment_17957", "id": "reaction_10606457", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10606454", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10662783": { "compartment": "compartment_70101", "id": "reaction_10662783", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10662772" ], "products": [ "species_10628859", "species_10662776" ], "modifiers": [ [ "species_10662772", "catalyst" ], [ "species_10662781", "inhibitor" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601258": { "compartment": "compartment_70101", "id": "reaction_10601258", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10601197" ], "products": [ "species_10601199" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10627051": { "compartment": "compartment_20699", "id": "reaction_10627051", "reactome": "R-CEL-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10627048", "catalyst" ] ], "additional_components": [ "Q9GUM2", "WBGene00000269", "G5EGS9", "WBGene00012206" ] }, "reaction_10659540": { "compartment": "compartment_70101", "id": "reaction_10659540", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10655541", "species_1131164", "species_10659531" ], "products": [ "species_10659538" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099" ] }, "reaction_10622073": { "compartment": "compartment_17957", "id": "reaction_10622073", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10622070", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10606473": { "compartment": "compartment_12045", "id": "reaction_10606473", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10606470", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10622158": { "compartment": "compartment_17957", "id": "reaction_10622158", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10662739": { "compartment": "compartment_70101", "id": "reaction_10662739", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662726" ], "products": [ "species_10648618", "species_10662736" ], "modifiers": [ [ "species_10658432", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q93725", "WBGene00003587", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "A0A0K3AQR5", "T28F2.2b", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00003587", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q7JP60", "WBGene00019959", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "Q9U3C8", "WBGene00010428", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A0A0K3AQR5", "T28F2.2b", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622134": { "compartment": "compartment_12045", "id": "reaction_10622134", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449222", "species_162756" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10622131", "catalyst" ] ], "additional_components": [ "U4PE03", "WBGene00019725", "P92012", "WBGene00011193" ] }, "reaction_10665016": { "compartment": "compartment_12045", "id": "reaction_10665016", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665014" ], "products": [ "species_10647827" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10622160": { "compartment": "compartment_17957", "id": "reaction_10622160", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10622155", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10657617": { "compartment": "compartment_70101", "id": "reaction_10657617", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628541", "species_29356" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10657614", "catalyst" ] ], "additional_components": [ "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P90859", "WBGene00009164", "Q9TW67", "WBGene00010160", "O16368", "WBGene00004502", "P54812", "WBGene00008053", "Q23451", "WBGene00013924", "Q9TXH9", "WBGene00017733", "Q93561", "WBGene00000843" ] }, "reaction_10659527": { "compartment": "compartment_70101", "id": "reaction_10659527", "reactome": "R-CEL-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659521" ], "products": [ "species_10659525" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00004184", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10622089": { "compartment": "compartment_17957", "id": "reaction_10622089", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10622086", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10647344": { "compartment": "compartment_70101", "id": "reaction_10647344", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10601707" ], "products": [ "species_174390", "species_10601705" ], "modifiers": [ [ "species_10647341", "catalyst" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "P34436", "WBGene00018419" ] }, "reaction_10622168": { "compartment": "compartment_12045", "id": "reaction_10622168", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10622165", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10647352": { "compartment": "compartment_70101", "id": "reaction_10647352", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10647349", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10654760": { "compartment": "compartment_70101", "id": "reaction_10654760", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10654738", "species_71284" ], "products": [ "species_10654745", "species_71285" ], "modifiers": [ [ "species_10654757", "catalyst" ] ], "additional_components": [ "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10647679": { "compartment": "compartment_7660", "id": "reaction_10647679", "reactome": "R-CEL-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647675", "species_10647670" ], "products": [ "species_10647677" ], "modifiers": [], "additional_components": [ "WBGene00015217", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q10655", "WBGene00001250", "G5EGN3", "WBGene00001253", "U4PMB4", "WBGene00001186", "Q17525", "WBGene00015217" ] }, "reaction_10626198": { "compartment": "compartment_20699", "id": "reaction_10626198", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10626195", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10648804": { "compartment": "compartment_70101", "id": "reaction_10648804", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10648801", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10606465": { "compartment": "compartment_12045", "id": "reaction_10606465", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10606462", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10601558": { "compartment": "compartment_70101", "id": "reaction_10601558", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601175", "species_10601180", "species_10601108" ], "products": [ "species_10601556" ], "modifiers": [], "additional_components": [ "O61820", "WBGene00001228", "Q9XWP7", "WBGene00012738", "P34339", "WBGene00001209", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "P30642", "WBGene00001227", "Q94261", "WBGene00019543", "Q9XUP3", "WBGene00001233", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "Q18967", "WBGene00001229", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "WBGene00019162", "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10601550": { "compartment": "compartment_70101", "id": "reaction_10601550", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601544" ], "products": [ "species_10601548", "species_10601546", "species_29372" ], "modifiers": [], "additional_components": [ "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "species_29420", "G5EGT7", "WBGene00021857" ] }, "reaction_10606481": { "compartment": "compartment_70101", "id": "reaction_10606481", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10606478", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10614701": { "compartment": "compartment_876", "id": "reaction_10614701", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614687", "species_10614677", "species_10614697", "species_10614672", "species_10614692", "species_10614682", "species_10614667", "species_10614662" ], "products": [ "species_10614699" ], "modifiers": [], "additional_components": [ "WBGene00018703", "WBGene00016188", "WBGene00016606", "WBGene00016376", "WBGene00017284", "WBGene00013687", "WBGene00004752", "WBGene00004753", "Q18286", "WBGene00016188", "Q19262", "WBGene00017284", "Q18406", "WBGene00016376", "P91149", "WBGene00016606", "Q20678", "WBGene00018703", "Q95Q35", "WBGene00013687", "Q22706", "WBGene00004752", "Q9XWS2", "WBGene00004753" ] }, "reaction_10658789": { "compartment": "compartment_70101", "id": "reaction_10658789", "reactome": "R-CEL-8865774", "name": "TTLLs polyglutamylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_113592", "species_29404" ], "products": [ "species_29370", "species_10658759", "species_29372" ], "modifiers": [ [ "species_10658786", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q564U4", "WBGene00044187", "H2KZM9", "WBGene00019230", "Q09512", "WBGene00008405", "Q09647", "WBGene00014232", "E9P886", "WBGene00008331" ] }, "reaction_10620021": { "compartment": "compartment_876", "id": "reaction_10620021", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620018", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10622109": { "compartment": "compartment_17957", "id": "reaction_10622109", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10622106", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10659795": { "compartment": "compartment_70101", "id": "reaction_10659795", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659631", "species_1131164" ], "products": [ "species_10659790", "species_111294", "species_10659792" ], "modifiers": [ [ "species_10659631", "catalyst" ] ], "additional_components": [ "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662768": { "compartment": "compartment_7660", "id": "reaction_10662768", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662761" ], "products": [ "species_10662763", "species_10662765" ], "modifiers": [ [ "species_10648738", "catalyst" ] ], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q93725", "WBGene00003587", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00003587", "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q9U3C8", "WBGene00010428", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "A0A0K3AQR5", "T28F2.2b", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814" ] }, "reaction_10622081": { "compartment": "compartment_12045", "id": "reaction_10622081", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10622078", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10647620": { "compartment": "compartment_2133233", "id": "reaction_10647620", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10647617", "catalyst" ] ], "additional_components": [ "species_1602402", "species_194276", "species_1602402", "species_194276", "WBGene00000020" ] }, "reaction_10650582": { "compartment": "compartment_3828046", "id": "reaction_10650582", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647837" ], "products": [ "species_10647960" ], "modifiers": [], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993" ] }, "reaction_10628543": { "compartment": "compartment_70101", "id": "reaction_10628543", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628539" ], "products": [ "species_10628541" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "species_915149", "CHEBI:60627", "species_964740", "CHEBI:60629", "CHEBI:60628", "P0CG71", "WBGene00006727" ] }, "reaction_10662774": { "compartment": "compartment_70101", "id": "reaction_10662774", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662770", "species_10628807" ], "products": [ "species_10662772" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "WBGene00001851", "Q17390", "WBGene00000837", "Q7JP60", "WBGene00019959", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "A0A0K3AQR5", "T28F2.2b", "Q93725", "WBGene00003587", "Q9BKS1", "WBGene00001236", "Q9U3C8", "WBGene00010428", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10601260": { "compartment": "compartment_70101", "id": "reaction_10601260", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601199", "species_72393" ], "products": [ "species_10601201" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560" ] }, "reaction_10633480": { "compartment": "compartment_70101", "id": "reaction_10633480", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633474", "species_10633476" ], "products": [ "species_10633478" ], "modifiers": [], "additional_components": [ "O16927", "WBGene00017799", "P91240", "WBGene00017245", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447", "Q95Y90", "WBGene00004420", "O16927", "WBGene00017799", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "O61749", "WBGene00018159", "P91374", "WBGene00004427", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P34642", "WBGene00013984", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "G5EE80", "WBGene00009012", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P91240", "WBGene00017245", "P90983", "WBGene00004498", "Q20822", "WBGene00010097", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10601560": { "compartment": "compartment_70101", "id": "reaction_10601560", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601556", "species_10601201" ], "products": [ "species_10601203" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "species_29438", "Q21230", "WBGene00010560", "Q9N3X2", "WBGene00004473", "Q9TXU7", "WBGene00019162", "O01974", "WBGene00001231", "Q9XWI6", "WBGene00001225", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "Q21230", "WBGene00010560", "Q19706", "WBGene00001230", "Q965S8", "WBGene00001232", "Q9XWP7", "WBGene00012738", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q9BKU3", "WBGene00021351", "P34339", "WBGene00001209", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "Q94261", "WBGene00019543", "P90983", "WBGene00004498", "O02328", "WBGene00001226", "Q95QW0", "WBGene00015920", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "species_29438", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "O61820", "WBGene00001228", "P48156", "WBGene00004477", "Q95XR0", "WBGene00021466", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "P30642", "WBGene00001227", "Q9XUP3", "WBGene00001233", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "Q18967", "WBGene00001229" ] }, "reaction_10622142": { "compartment": "compartment_12045", "id": "reaction_10622142", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10622139", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10601252": { "compartment": "compartment_70101", "id": "reaction_10601252", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601231", "species_10601226", "species_10601221" ], "products": [ "species_10601233" ], "modifiers": [], "additional_components": [ "WBGene00002066", "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10659633": { "compartment": "compartment_70101", "id": "reaction_10659633", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659538", "species_10659629" ], "products": [ "species_10659631" ], "modifiers": [], "additional_components": [ "species_1131164", "Q9TYY0", "WBGene00019778", "Q9BKQ5", "WBGene00022051", "P41992", "WBGene00015099", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272", "P91857", "WBGene00004268", "Q22908", "WBGene00016344", "Q8MXS1", "WBGene00004277", "Q9UAQ6", "WBGene00004266", "O17788", "WBGene00008672", "Q18969", "WBGene00004286", "Q93874", "WBGene00004276", "A0A2C9C2Y0", "WBGene00006833", "Q22782", "WBGene00004270", "species_29420", "G5EBF0", "WBGene00011083", "Q94148", "WBGene00004273", "G5EFA6", "WBGene00004285", "Q9U1W9", "WBGene00004278", "Q9BKQ5", "WBGene00022051", "Q18773", "WBGene00016874", "Q23146", "WBGene00004271", "Q94986", "WBGene00004267", "Q20365", "WBGene00004283", "O17789", "WBGene00008672", "Q9U2C3", "WBGene00004284", "species_1131164", "Q22045", "WBGene00004279", "G5EBS5", "WBGene00000089", "O01803", "WBGene00004274", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P34213", "WBGene00004269", "Q9XWZ3", "WBGene00004282", "G5EFC1", "WBGene00004272" ] }, "reaction_10662660": { "compartment": "compartment_7660", "id": "reaction_10662660", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662451", "species_10662656" ], "products": [ "species_10662658" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320", "WBGene00013606", "Q18963", "WBGene00008403", "G5ED41", "WBGene00013606", "Q17963", "WBGene00006474", "Q21934", "WBGene00011242", "Q965F9", "WBGene00003917", "Q21554", "WBGene00010890", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "P90794", "WBGene00008419", "Q23494", "WBGene00022742", "Q93759", "WBGene00009976", "Q17392", "WBGene00000839", "Q09309", "WBGene00017683", "Q09392", "WBGene00018564", "Q23457", "WBGene00004320" ] }, "reaction_10606489": { "compartment": "compartment_12045", "id": "reaction_10606489", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10606486", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10661701": { "compartment": "compartment_70101", "id": "reaction_10661701", "reactome": "R-CEL-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10661694", "species_113592", "species_10648618" ], "products": [ "species_10661699", "species_111294", "species_76577" ], "modifiers": [], "additional_components": [ "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587", "WBGene00003587", "Q18217", "WBGene00006735", "Q19360", "WBGene00004341", "Q93725", "WBGene00003587" ] }, "reaction_10622064": { "compartment": "compartment_17957", "id": "reaction_10622064", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10622056", "catalyst" ], [ "species_10622062", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10647958": { "compartment": "compartment_3828046", "id": "reaction_10647958", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647827", "species_5685882" ], "products": [ "species_10647847", "species_10647837", "species_10647857" ], "modifiers": [ [ "species_10647955", "catalyst" ] ], "additional_components": [ "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "V6CM12", "WBGene00004992", "Q18276", "WBGene00004995", "O17387", "WBGene00004998", "Q18279", "WBGene00004993", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "Q9BL26", "WBGene00044760", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O01532", "WBGene00000218", "Q8MYN7", "WBGene00012681", "Q2AAB9", "WBGene00044760", "O17255", "WBGene00044760", "Q22972", "WBGene00017881", "O01530", "WBGene00000219", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "U4PME4", "WBGene00044760" ] }, "reaction_10605938": { "compartment": "compartment_70101", "id": "reaction_10605938", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605934" ], "products": [ "species_10605936" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10662654": { "compartment": "compartment_70101", "id": "reaction_10662654", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10662650", "species_10648772" ], "products": [ "species_10662652" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "WBGene00013606", "A0A0K3AV89", "Y32G9A.6d", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "O62200", "WBGene00018654", "Q17390", "WBGene00000837", "Q9GRV5", "WBGene00006616", "Q20183", "WBGene00006415", "Q965N7", "WBGene00021596", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "O45498", "WBGene00009556", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9GYM5", "WBGene00019782", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q965N6", "WBGene00021597", "Q8MQ13", "WBGene00018654", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "Q17490", "WBGene00006780", "P17221", "WBGene00001411", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "O61795", "WBGene00020030", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "G5EGS4", "WBGene00002184", "G5ED41", "WBGene00013606", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "Q9BL53", "WBGene00022139", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10601552": { "compartment": "compartment_70101", "id": "reaction_10601552", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601246", "species_10601542", "species_10601533" ], "products": [ "species_10601544" ], "modifiers": [], "additional_components": [ "Q9N3X2", "WBGene00004473", "O01692", "WBGene00004486", "Q19877", "WBGene00004492", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q8WQA8", "WBGene00004489", "Q20206", "WBGene00004480", "Q9NEN6", "WBGene00004475", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P46769", "WBGene00004469", "Q20228", "WBGene00004478", "O01869", "WBGene00004479", "P48152", "WBGene00004472", "P49041", "WBGene00004474", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O17218", "WBGene00004491", "Q23312", "WBGene00004476", "P51403", "WBGene00004471", "Q95Y04", "WBGene00004497", "O45499", "WBGene00004495", "P48156", "WBGene00004477", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "Q22054", "WBGene00004485", "G5EGT7", "WBGene00021857", "species_29438", "Q95Y90", "WBGene00004420", "P91128", "WBGene00004425", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "P49405", "WBGene00004416", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O44480", "WBGene00004432", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "Q09533", "WBGene00004421", "P91374", "WBGene00004427", "O17570", "WBGene00004452", "Q27389", "WBGene00004428", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "P48158", "WBGene00004435", "Q22716", "WBGene00004446", "O02639", "WBGene00004431", "Q9XVE9", "WBGene00004426", "Q966C6", "WBGene00004419", "O02056", "WBGene00004415", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P61866", "WBGene00004424", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "P49180", "WBGene00004447", "P48162", "WBGene00004438", "Q95Y90", "WBGene00004420", "Q9N3X2", "WBGene00004473", "Q19869", "WBGene00004440", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P49181", "WBGene00004450", "O01802", "WBGene00004418", "P47991", "WBGene00004417", "O44480", "WBGene00004432", "P91374", "WBGene00004427", "G5EGT7", "WBGene00021857", "Q8WQA8", "WBGene00004489", "Q27389", "WBGene00004428", "Q9NEN6", "WBGene00004475", "P46769", "WBGene00004469", "Q9BL19", "WBGene00004429", "Q9BKU5", "WBGene00021350", "Q9N4I4", "WBGene00004412", "Q93572", "WBGene00004408", "O01869", "WBGene00004479", "P49041", "WBGene00004474", "Q22716", "WBGene00004446", "P48154", "WBGene00004470", "Q1XFY9", "WBGene00004493", "O02639", "WBGene00004431", "Q966C6", "WBGene00004419", "O17218", "WBGene00004491", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "O45226", "WBGene00004443", "O45499", "WBGene00004495", "P0CG71", "WBGene00006727", "P91914", "WBGene00004441", "O18240", "WBGene00004487", "P48166", "WBGene00004454", "Q9XVF7", "WBGene00004413", "Q22054", "WBGene00004485", "P48162", "WBGene00004438", "P91128", "WBGene00004425", "P50880", "WBGene00004414", "P34662", "WBGene00004449", "O01692", "WBGene00004486", "P52814", "WBGene00004453", "O62388", "WBGene00012179", "Q19877", "WBGene00004492", "P49405", "WBGene00004416", "Q9TXP0", "WBGene00004496", "P52819", "WBGene00004434", "Q9U2A8", "WBGene00004456", "O01504", "WBGene00016493", "P91913", "WBGene00004409", "P48150", "WBGene00004483", "P51404", "WBGene00004482", "Q09533", "WBGene00004421", "Q20206", "WBGene00004480", "O17570", "WBGene00004452", "P49196", "WBGene00004481", "P90983", "WBGene00004498", "P34334", "WBGene00004433", "Q19162", "WBGene00004423", "Q20228", "WBGene00004478", "P48152", "WBGene00004472", "P48158", "WBGene00004435", "Q9XVE9", "WBGene00004426", "Q23312", "WBGene00004476", "species_29438", "Q21930", "WBGene00004442", "Q95Y04", "WBGene00004497", "P48156", "WBGene00004477", "O45946", "WBGene00004430", "O01868", "WBGene00004436", "P52821", "WBGene00004494", "P49197", "WBGene00004490", "P61866", "WBGene00004424", "O18650", "WBGene00004488", "Q9XVP0", "WBGene00004484", "P49180", "WBGene00004447" ] }, "reaction_10625280": { "compartment": "compartment_17957", "id": "reaction_10625280", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623945", "species_10625276" ], "products": [ "species_10625278" ], "modifiers": [], "additional_components": [ "WBGene00003964", "P34652", "WBGene00000567", "CHEBI:59080", "P27798", "WBGene00000802", "P34652", "WBGene00000567", "CHEBI:59080", "G5ED07", "WBGene00003964", "P27798", "WBGene00000802" ] }, "reaction_10659533": { "compartment": "compartment_70101", "id": "reaction_10659533", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659523", "species_10659529" ], "products": [ "species_10659531" ], "modifiers": [ [ "species_10659525", "inhibitor" ] ], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "G5EG43", "WBGene00004184", "P41992", "WBGene00015099" ] }, "reaction_10630959": { "compartment": "compartment_12045", "id": "reaction_10630959", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10661834": { "compartment": "compartment_984", "id": "reaction_10661834", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10661831", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10660478": { "compartment": "compartment_5460", "id": "reaction_10660478", "reactome": "R-CEL-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10660475", "catalyst" ] ], "additional_components": [ "WBGene00008801" ] }, "reaction_10631941": { "compartment": "compartment_984", "id": "reaction_10631941", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_109276" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631070": { "compartment": "compartment_12045", "id": "reaction_10631070", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10631067", "catalyst" ] ], "additional_components": [ "Q9U2G1", "WBGene00012897", "species_266099", "species_109496" ] }, "reaction_10631934": { "compartment": "compartment_984", "id": "reaction_10631934", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602375" ], "products": [ "species_1602366", "species_1602372" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631217": { "compartment": "compartment_20699", "id": "reaction_10631217", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631155" ], "products": [ "species_10631215" ], "modifiers": [], "additional_components": [ "Q965T2", "WBGene00021854", "species_194276", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631939": { "compartment": "compartment_984", "id": "reaction_10631939", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10631075": { "compartment": "compartment_70101", "id": "reaction_10631075", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970", "species_1500578" ], "products": [ "species_76194", "species_75973" ], "modifiers": [ [ "species_10631072", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10630911": { "compartment": "compartment_17906", "id": "reaction_10630911", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10630908", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10630922": { "compartment": "compartment_12045", "id": "reaction_10630922", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10623952": { "compartment": "compartment_12045", "id": "reaction_10623952", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10603021", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q9N5S8", "WBGene00018657", "Q21812", "WBGene00011106" ] }, "reaction_10631123": { "compartment": "compartment_70616", "id": "reaction_10631123", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524067", "species_1524072" ], "modifiers": [ [ "species_10630900", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10603078": { "compartment": "compartment_70101", "id": "reaction_10603078", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_75970" ], "products": [ "species_29360", "species_76114" ], "modifiers": [ [ "species_10603075", "catalyst" ] ], "additional_components": [ "P34517", "WBGene00010778", "Q9XTS4", "WBGene00009824" ] }, "reaction_10660215": { "compartment": "compartment_12045", "id": "reaction_10660215", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10660211" ], "products": [ "species_10660213" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10631235": { "compartment": "compartment_12045", "id": "reaction_10631235", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631219" ], "products": [ "species_10631153" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "species_426639", "Q965T2", "WBGene00021854" ] }, "reaction_10630997": { "compartment": "compartment_12045", "id": "reaction_10630997", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630967": { "compartment": "compartment_17906", "id": "reaction_10630967", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10603038", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10630944": { "compartment": "compartment_12045", "id": "reaction_10630944", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10630941", "catalyst" ] ], "additional_components": [ "H9G2W5", "WBGene00007446", "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631007": { "compartment": "compartment_12045", "id": "reaction_10631007", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10630887": { "compartment": "compartment_12045", "id": "reaction_10630887", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10630919": { "compartment": "compartment_12045", "id": "reaction_10630919", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10630916", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10649397": { "compartment": "compartment_70101", "id": "reaction_10649397", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10649394", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10631146": { "compartment": "compartment_12045", "id": "reaction_10631146", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10631143", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10649433": { "compartment": "compartment_17906", "id": "reaction_10649433", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10649430", "catalyst" ] ], "additional_components": [ "species_114519", "species_6814795", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_109496" ] }, "reaction_10631014": { "compartment": "compartment_12045", "id": "reaction_10631014", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10631004", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10659846": { "compartment": "compartment_70101", "id": "reaction_10659846", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659841", "species_113592" ], "products": [ "species_29370", "species_10659844" ], "modifiers": [ [ "species_10612071", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10631167": { "compartment": "compartment_12045", "id": "reaction_10631167", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10631164", "catalyst" ] ], "additional_components": [ "P53439", "WBGene00016384", "species_109496" ] }, "reaction_10609637": { "compartment": "compartment_5460", "id": "reaction_10609637", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10609634", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10649368": { "compartment": "compartment_876", "id": "reaction_10649368", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10649365", "catalyst" ] ], "additional_components": [ "Q9U1Z6", "WBGene00013358", "Q18610", "WBGene00016644" ] }, "reaction_10631157": { "compartment": "compartment_20699", "id": "reaction_10631157", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631153", "species_429785" ], "products": [ "species_1524146", "species_10631155" ], "modifiers": [], "additional_components": [ "species_426639", "Q965T2", "WBGene00021854", "Q965T2", "WBGene00021854", "species_194276" ] }, "reaction_10631041": { "compartment": "compartment_12045", "id": "reaction_10631041", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10631038", "catalyst" ] ], "additional_components": [ "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631060": { "compartment": "compartment_20699", "id": "reaction_10631060", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10631057", "catalyst" ] ], "additional_components": [ "G5EC25", "WBGene00013024", "species_266099", "species_109496" ] }, "reaction_10631190": { "compartment": "compartment_12045", "id": "reaction_10631190", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10631187", "catalyst" ] ], "additional_components": [ "WBGene00012095" ] }, "reaction_10631120": { "compartment": "compartment_70101", "id": "reaction_10631120", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10631117", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "P46558", "WBGene00000511", "O17610", "WBGene00000509", "P46559", "WBGene00000512", "Q22942", "WBGene00000510", "Q9GZF3", "WBGene00000514" ] }, "reaction_10631016": { "compartment": "compartment_12045", "id": "reaction_10631016", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10630994", "catalyst" ] ], "additional_components": [ "WBGene00022233" ] }, "reaction_10630906": { "compartment": "compartment_12045", "id": "reaction_10630906", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10630884", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "O01925", "WBGene00020115" ] }, "reaction_10631182": { "compartment": "compartment_12045", "id": "reaction_10631182", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10631177", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10631937": { "compartment": "compartment_984", "id": "reaction_10631937", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_109276" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10626935", "catalyst" ] ], "additional_components": [ "WBGene00022040" ] }, "reaction_10603033": { "compartment": "compartment_12045", "id": "reaction_10603033", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10603030", "catalyst" ] ], "additional_components": [ "Q95R12", "WBGene00017888", "G5EE59", "WBGene00010902", "Q22267", "WBGene00011543", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q21812", "WBGene00011106" ] }, "reaction_10631932": { "compartment": "compartment_984", "id": "reaction_10631932", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426658", "species_109276" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10631910", "catalyst" ], [ "species_10631925", "inhibitor" ] ], "additional_components": [ "species_74016", "Q18339", "WBGene00016288", "P34312", "WBGene00007399", "Q17452", "WBGene00015052", "P34472", "WBGene00010228", "Q17450", "WBGene00015050", "Q22591", "WBGene00020585", "P91429", "WBGene00020191" ] }, "reaction_10615365": { "compartment": "compartment_984", "id": "reaction_10615365", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10615360", "catalyst" ], [ "species_10615363", "inhibitor" ] ], "additional_components": [ "O01302", "WBGene00011362", "Q9U295", "WBGene00000037", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10659441": { "compartment": "compartment_70101", "id": "reaction_10659441", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10659438", "catalyst" ] ], "additional_components": [ "G5EEM9", "WBGene00019747", "G5EED9", "WBGene00010813" ] }, "reaction_10659911": { "compartment": "compartment_12045", "id": "reaction_10659911", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10659908", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "WBGene00010943" ] }, "reaction_10602878": { "compartment": "compartment_7660", "id": "reaction_10602878", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602869", "species_10602874" ], "products": [ "species_10602876" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10664492": { "compartment": "compartment_70101", "id": "reaction_10664492", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664474", "species_10617465" ], "products": [ "species_10664476" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664490": { "compartment": "compartment_17947", "id": "reaction_10664490", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664476", "species_10617443" ], "products": [ "species_10664478" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "WBGene00004193", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201" ] }, "reaction_10664488": { "compartment": "compartment_17947", "id": "reaction_10664488", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664478" ], "products": [ "species_10664486", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "Q18028", "WBGene00004193", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P34453", "WBGene00004201", "Q19189", "WBGene00004197", "O44555", "WBGene00000111", "Q9XTZ5", "WBGene00007680", "P54815", "WBGene00010557", "A0A486WWU7", "WBGene00000110", "P91262", "WBGene00017574", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "WBGene00004193", "WBGene00004201" ] }, "reaction_10657346": { "compartment": "compartment_70101", "id": "reaction_10657346", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657343", "catalyst" ] ], "additional_components": [ "WBGene00015484" ] }, "reaction_10657341": { "compartment": "compartment_70101", "id": "reaction_10657341", "reactome": "R-CEL-8848338", "name": "PNPLA4 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_29356" ], "products": [ "species_76103", "species_8876730" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10643167": { "compartment": "compartment_70101", "id": "reaction_10643167", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10643163", "species_8876730" ], "products": [ "species_10643165" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_8876730", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10657349": { "compartment": "compartment_70101", "id": "reaction_10657349", "reactome": "R-CEL-8848355", "name": "PNPLA4 hydrolyzes retinyl palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2534407", "species_29356" ], "products": [ "species_8848337", "species_30209" ], "modifiers": [ [ "species_10657338", "catalyst" ] ], "additional_components": [ "WBGene00015241" ] }, "reaction_10664778": { "compartment": "compartment_70101", "id": "reaction_10664778", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664735", "species_10664774" ], "products": [ "species_10664776" ], "modifiers": [], "additional_components": [ "Q21746", "WBGene00019893", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q19967", "WBGene00001303", "Q93315", "WBGene00007848", "A0A486WWU7", "WBGene00000110", "O16000", "WBGene00006798", "Q95XS2", "WBGene00021427", "O02495", "WBGene00004897", "A0A2K5ATR7", "WBGene00022450", "O44555", "WBGene00000111", "P34351", "WBGene00004899", "Q93838", "WBGene00010337", "Q20797", "WBGene00006373", "O44782", "WBGene00018008", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10664366": { "compartment": "compartment_17947", "id": "reaction_10664366", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664361" ], "products": [ "species_10628859", "species_10664363" ], "modifiers": [ [ "species_10664361", "catalyst" ] ], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "P0CG71", "WBGene00006727", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q20617", "WBGene00006719", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "P0CG71", "WBGene00006727" ] }, "reaction_10664355": { "compartment": "compartment_17947", "id": "reaction_10664355", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664321", "species_10664319" ], "products": [ "species_10664323" ], "modifiers": [], "additional_components": [ "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034" ] }, "reaction_10664353": { "compartment": "compartment_17947", "id": "reaction_10664353", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664323" ], "products": [ "species_10664351", "species_10662601" ], "modifiers": [], "additional_components": [ "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "Q19189", "WBGene00004197", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "Q19951", "WBGene00004198", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q18355", "WBGene00016318", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "Q93930", "WBGene00004199", "Q18426", "WBGene00004194", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "B1GRK5", "WBGene00018286", "H9G2T4", "WBGene00010317", "G5EGA6", "WBGene00010063", "O62138", "WBGene00008566", "Q19878", "WBGene00009218", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q7YWV6", "WBGene00011826", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q20959", "WBGene00019022", "Q93839", "WBGene00010336", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "Q17474", "WBGene00007143", "Q8MYL7", "WBGene00013220", "Q9GYN3", "WBGene00020989", "O62140", "WBGene00008564", "O45003", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q19564", "WBGene00017565", "P91148", "WBGene00003584", "Q95XN1", "WBGene00022150", "G5EDP2", "WBGene00013284", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "O62137", "WBGene00008565", "O16249", "WBGene00018426", "B3WFZ3", "WBGene00020989", "O45307", "WBGene00008127", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q18006", "WBGene00015783", "Q17499", "WBGene00007175", "O01862", "WBGene00020989", "O62139", "WBGene00008567", "P34355", "WBGene00008167", "Q18916", "WBGene00017012", "Q9XW87", "WBGene00013541", "Q18122", "WBGene00016034", "Q19189", "WBGene00004197", "Q18355", "WBGene00016318", "Q18426", "WBGene00004194", "Q93930", "WBGene00004199", "Q19951", "WBGene00004198" ] }, "reaction_10664944": { "compartment": "compartment_70101", "id": "reaction_10664944", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664940", "species_10664735" ], "products": [ "species_10664942" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q21746", "WBGene00019893" ] }, "reaction_10625255": { "compartment": "compartment_70101", "id": "reaction_10625255", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10625216", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10625195": { "compartment": "compartment_70101", "id": "reaction_10625195", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625192", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10625801": { "compartment": "compartment_917758", "id": "reaction_10625801", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614063", "species_10613945", "species_10614053", "species_10625246", "species_10614048" ], "products": [ "species_10625248" ], "modifiers": [ [ "species_10625246", "catalyst" ] ], "additional_components": [ "WBGene00006798", "WBGene00006750", "WBGene00006757", "WBGene00022271", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "E5QCE7", "WBGene00001032", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_352003", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "G5EDB7", "WBGene00006762", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "P34579", "WBGene00006783", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10625207": { "compartment": "compartment_917757", "id": "reaction_10625207", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10625204", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10607988": { "compartment": "compartment_70101", "id": "reaction_10607988", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607978", "species_29356" ], "products": [ "species_111294", "species_10607968" ], "modifiers": [ [ "species_10607985", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "P81299", "WBGene00000383" ] }, "reaction_10650541": { "compartment": "compartment_984", "id": "reaction_10650541", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10650538", "catalyst" ] ], "additional_components": [ "Q20449", "WBGene00009773", "E2S7J2", "WBGene00021963", "Q94252", "WBGene00019376", "O61866", "WBGene00022642", "Q93789", "WBGene00010062", "Q9U276", "WBGene00013050", "O17766", "WBGene00008510", "O16956", "WBGene00020016" ] }, "reaction_10657183": { "compartment": "compartment_876", "id": "reaction_10657183", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657179", "species_10657165" ], "products": [ "species_10657181" ], "modifiers": [], "additional_components": [ "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "WBGene00006875", "Q18825", "WBGene00000238", "A0A1N7SYP3", "WBGene00006876", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "O44326", "WBGene00001979", "G5ED30", "WBGene00006875", "Q10953", "WBGene00006943" ] }, "reaction_10664096": { "compartment": "compartment_70101", "id": "reaction_10664096", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664158": { "compartment": "compartment_70101", "id": "reaction_10664158", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664108": { "compartment": "compartment_70101", "id": "reaction_10664108", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_111745", "species_9024815" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10664098": { "compartment": "compartment_70101", "id": "reaction_10664098", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664102": { "compartment": "compartment_70101", "id": "reaction_10664102", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664104": { "compartment": "compartment_70101", "id": "reaction_10664104", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664100": { "compartment": "compartment_70101", "id": "reaction_10664100", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10664106": { "compartment": "compartment_70101", "id": "reaction_10664106", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_9024463", "species_29356", "species_111745" ], "modifiers": [ [ "species_10664087", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10648108": { "compartment": "compartment_7660", "id": "reaction_10648108", "reactome": "R-CEL-5686578", "name": "Activated ATM phosphorylates ABL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648103" ], "products": [ "species_113582", "species_10648106" ], "modifiers": [ [ "species_10614888", "catalyst" ] ], "additional_components": [ "WBGene00000018", "WBGene00000018", "WBGene00000227" ] }, "reaction_10648895": { "compartment": "compartment_7660", "id": "reaction_10648895", "reactome": "R-CEL-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648884" ], "products": [ "species_113582", "species_10647722" ], "modifiers": [ [ "species_10648884", "catalyst" ] ], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10648892": { "compartment": "compartment_7660", "id": "reaction_10648892", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648889" ], "products": [ "species_113582", "species_10647734" ], "modifiers": [ [ "species_10648889", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647750": { "compartment": "compartment_7660", "id": "reaction_10647750", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10647734" ], "products": [ "species_113550", "species_10647747" ], "modifiers": [ [ "species_10647707", "catalyst" ] ], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "WBGene00001377" ] }, "reaction_10647638": { "compartment": "compartment_7660", "id": "reaction_10647638", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647634" ], "products": [ "species_10647636" ], "modifiers": [], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10647737": { "compartment": "compartment_7660", "id": "reaction_10647737", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647698" ], "products": [ "species_113582", "species_10647707" ], "modifiers": [ [ "species_10647734", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10648897": { "compartment": "compartment_7660", "id": "reaction_10648897", "reactome": "R-CEL-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10647693" ], "products": [ "species_10648889" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885" ] }, "reaction_10647759": { "compartment": "compartment_7660", "id": "reaction_10647759", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647755", "species_10607264", "species_10647734" ], "products": [ "species_10647757" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "P04255", "WBGene00001885", "Q9BKZ9", "WBGene00001410", "Q27894", "WBGene00001878", "Q27484", "WBGene00001915", "Q8WQG9", "WBGene00002178", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "P04255", "WBGene00001885", "P09588", "WBGene00001877", "Q27876", "WBGene00001922", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q27485", "WBGene00001909", "P62784", "WBGene00001875" ] }, "reaction_10647653": { "compartment": "compartment_7660", "id": "reaction_10647653", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647636" ], "products": [ "species_113582", "species_10647650" ], "modifiers": [ [ "species_10647636", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612", "Q9U1Y5", "WBGene00000499", "A4F324", "WBGene00011612" ] }, "reaction_10658362": { "compartment": "compartment_876", "id": "reaction_10658362", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658356", "species_10658351" ], "products": [ "species_10658360" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P91493", "WBGene00004924", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "P90761", "WBGene00006777" ] }, "reaction_10658873": { "compartment": "compartment_876", "id": "reaction_10658873", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10658793" ], "products": [ "species_10658869" ], "modifiers": [ [ "species_10658871", "inhibitor" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "P34574", "WBGene00011867", "O18014", "WBGene00011381", "Q9N489", "WBGene00022453", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P51485", "WBGene00000195", "Q9U7D5", "WBGene00001519", "Q9BIF4", "WBGene00001224", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "A0A0K3AS36", "Y116A8C.36d", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "species_179856", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10659086": { "compartment": "compartment_876", "id": "reaction_10659086", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659080", "species_10659078" ], "products": [ "species_10659084" ], "modifiers": [], "additional_components": [ "WBGene00006751", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "Q9XZI6", "WBGene00006751", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898" ] }, "reaction_10658373": { "compartment": "compartment_876", "id": "reaction_10658373", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658364", "species_10658369" ], "products": [ "species_10658371" ], "modifiers": [], "additional_components": [ "WBGene00000894", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10658436": { "compartment": "compartment_70101", "id": "reaction_10658436", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658432", "species_10658414", "species_10658396" ], "products": [ "species_10658434" ], "modifiers": [], "additional_components": [ "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10658849": { "compartment": "compartment_876", "id": "reaction_10658849", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_10658843" ], "products": [ "species_10658845" ], "modifiers": [ [ "species_10658847", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "P34711", "WBGene00006756", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q11124", "WBGene00015389", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658795": { "compartment": "compartment_876", "id": "reaction_10658795", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10658791" ], "products": [ "species_10658793" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519", "Q09638", "WBGene00012084", "O18014", "WBGene00011381", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q03566", "WBGene00006576", "A0A0K3AUI8", "C34F11.9e", "O62189", "WBGene00009278", "P91439", "WBGene00020319", "O76667", "WBGene00019183", "Q18239", "WBGene00001102", "P51485", "WBGene00000195", "Q9N532", "WBGene00003238", "Q9U7D5", "WBGene00001519" ] }, "reaction_10658867": { "compartment": "compartment_876", "id": "reaction_10658867", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658821", "species_10658863" ], "products": [ "species_10658865" ], "modifiers": [], "additional_components": [ "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109", "P34574", "WBGene00011867", "P29355", "WBGene00004774", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19019", "WBGene00004829", "Q9N4F3", "WBGene00000160", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "G5EFK8", "WBGene00008779", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "P0CG71", "WBGene00006727", "Q19123", "WBGene00000157", "Q17796", "WBGene00004101", "P90961", "WBGene00020246", "Q6A573", "WBGene00021549", "O01498", "WBGene00004109" ] }, "reaction_10658441": { "compartment": "compartment_70101", "id": "reaction_10658441", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648614", "species_10658356" ], "products": [ "species_10658396" ], "modifiers": [], "additional_components": [ "WBGene00003587", "WBGene00006777", "WBGene00006777" ] }, "reaction_10658825": { "compartment": "compartment_70101", "id": "reaction_10658825", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658815", "species_10658821" ], "products": [ "species_10658823" ], "modifiers": [], "additional_components": [ "G5EFF7", "WBGene00008852", "P90879", "WBGene00009878", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "G5EFF7", "WBGene00008852", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "P90879", "WBGene00009878" ] }, "reaction_10665766": { "compartment": "compartment_70101", "id": "reaction_10665766", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10641905", "species_9648300" ], "products": [ "species_10658847" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "species_9648300" ] }, "reaction_10658439": { "compartment": "compartment_70101", "id": "reaction_10658439", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658434" ], "products": [ "species_10658432", "species_10658414", "species_10648614", "species_10658356" ], "modifiers": [ [ "species_10658434", "catalyst" ] ], "additional_components": [ "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "O45271", "WBGene00006597", "Q9XXG5", "WBGene00006598", "Q95NU5", "WBGene00003870", "WBGene00003587", "WBGene00006777", "Q9N425", "WBGene00000815", "O45271", "WBGene00006597", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9XXG5", "WBGene00006598", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95NU5", "WBGene00003870", "P90761", "WBGene00006777", "O01422", "WBGene00000814" ] }, "reaction_10601944": { "compartment": "compartment_70101", "id": "reaction_10601944", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_73566", "species_29356" ], "products": [ "species_29404", "species_111294", "species_111292" ], "modifiers": [ [ "species_10601941", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10665762": { "compartment": "compartment_70101", "id": "reaction_10665762", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10601884" ], "products": [ "species_10601887" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10601903": { "compartment": "compartment_70101", "id": "reaction_10601903", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601889": { "compartment": "compartment_70101", "id": "reaction_10601889", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10601884", "catalyst" ], [ "species_10601887", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q9GZH3", "WBGene00020682", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10604753": { "compartment": "compartment_70101", "id": "reaction_10604753", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604749" ], "products": [ "species_10601941" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601877": { "compartment": "compartment_70101", "id": "reaction_10601877", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10601874", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10601946": { "compartment": "compartment_70101", "id": "reaction_10601946", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10601926": { "compartment": "compartment_70101", "id": "reaction_10601926", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_111370" ], "products": [ "species_70106", "species_111395" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10601590": { "compartment": "compartment_70101", "id": "reaction_10601590", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601923": { "compartment": "compartment_70101", "id": "reaction_10601923", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111395", "species_29448", "species_113592" ], "products": [ "species_70106", "species_29370", "species_29372", "species_111399" ], "modifiers": [ [ "species_10601920", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601941" ], "products": [ "species_10604749" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531", "CHEBI:17909", "Q22134", "WBGene00011407", "species_113531" ] }, "reaction_10601934": { "compartment": "compartment_70101", "id": "reaction_10601934", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10601931", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10601593": { "compartment": "compartment_70101", "id": "reaction_10601593", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10601587", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10601900": { "compartment": "compartment_70101", "id": "reaction_10601900", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10601897", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10601913": { "compartment": "compartment_70101", "id": "reaction_10601913", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10601910", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10604785": { "compartment": "compartment_70101", "id": "reaction_10604785", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10604782", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_109496" ] }, "reaction_10601603": { "compartment": "compartment_70101", "id": "reaction_10601603", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76633", "species_76632" ], "modifiers": [ [ "species_10601600", "catalyst" ] ], "additional_components": [ "species_73524", "O01815", "WBGene00020932" ] }, "reaction_10644465": { "compartment": "compartment_876", "id": "reaction_10644465", "reactome": "R-CEL-5602080", "name": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644461", "species_10605673" ], "products": [ "species_10644463" ], "modifiers": [], "additional_components": [ "species_977180", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "species_977180", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10658612": { "compartment": "compartment_70101", "id": "reaction_10658612", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29408", "species_29366" ], "modifiers": [ [ "species_10658609", "catalyst" ] ], "additional_components": [ "A0A061AD47", "WBGene00013289", "species_113596" ] }, "reaction_10628378": { "compartment": "compartment_5460", "id": "reaction_10628378", "reactome": "R-CEL-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10628375", "catalyst" ] ], "additional_components": [ "WBGene00014058" ] }, "reaction_10623673": { "compartment": "compartment_70101", "id": "reaction_10623673", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623615" ], "products": [ "species_10623671" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "U4PBJ9", "WBGene00022048", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "H2L2E8", "WBGene00006528", "H2KYR1", "WBGene00006924", "P19826", "WBGene00000942", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "P34690", "WBGene00006529", "P34815", "WBGene00006757", "Q23551", "WBGene00006759", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9N3B0", "WBGene00021888", "O44412", "WBGene00020298", "G5EEG0", "WBGene00000286", "O17939", "WBGene00010685", "O02159", "WBGene00020378", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10613311": { "compartment": "compartment_984", "id": "reaction_10613311", "reactome": "R-CEL-204824", "name": "Interaction of Tie2 and Ang4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613307" ], "products": [ "species_10613309" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10618750": { "compartment": "compartment_70101", "id": "reaction_10618750", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10628230": { "compartment": "compartment_70101", "id": "reaction_10628230", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628228" ], "products": [ "species_10628138" ], "modifiers": [], "additional_components": [ "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230" ] }, "reaction_10618759": { "compartment": "compartment_70101", "id": "reaction_10618759", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618742", "species_10618746", "species_10610070" ], "products": [ "species_10618748" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10605677": { "compartment": "compartment_984", "id": "reaction_10605677", "reactome": "R-CEL-140791", "name": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605667", "species_10605556" ], "products": [ "species_10605675" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10614194": { "compartment": "compartment_70101", "id": "reaction_10614194", "reactome": "R-CEL-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10614189", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613017": { "compartment": "compartment_20699", "id": "reaction_10613017", "reactome": "R-CEL-204500", "name": "CyP60 chaperones Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613013", "species_10613008" ], "products": [ "species_10613015" ], "modifiers": [], "additional_components": [ "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "P52012", "WBGene00000880", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10613023": { "compartment": "compartment_20699", "id": "reaction_10613023", "reactome": "R-CEL-204549", "name": "Caveolin-1 binds Basigin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613008", "species_10613019" ], "products": [ "species_10613021" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "WBGene00000301", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q94051", "WBGene00000301" ] }, "reaction_10605482": { "compartment": "compartment_70101", "id": "reaction_10605482", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10604943", "species_114519" ], "products": [ "species_10605480" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10620840": { "compartment": "compartment_70101", "id": "reaction_10620840", "reactome": "R-CEL-432143", "name": "PECAM-1 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10610622" ], "products": [ "species_10620838" ], "modifiers": [], "additional_components": [ "WBGene00006820", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "O01761", "WBGene00006820" ] }, "reaction_10618110": { "compartment": "compartment_876", "id": "reaction_10618110", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605490" ], "products": [ "species_10605439", "species_10605064", "species_10604843" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "species_29438" ] }, "reaction_10623452": { "compartment": "compartment_876", "id": "reaction_10623452", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623438" ], "products": [ "species_10623450" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "A0A1N7SYP5", "WBGene00009500", "Q11117", "WBGene00003053", "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471" ] }, "reaction_10612267": { "compartment": "compartment_876", "id": "reaction_10612267", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612263", "species_10612257", "species_266099" ], "products": [ "species_10612265" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929" ] }, "reaction_10613785": { "compartment": "compartment_876", "id": "reaction_10613785", "reactome": "R-CEL-210285", "name": "Trans-homophilic interaction of PECAM-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613781" ], "products": [ "species_10613783" ], "modifiers": [], "additional_components": [ "WBGene00006820", "O01761", "WBGene00006820" ] }, "reaction_10618771": { "compartment": "compartment_70101", "id": "reaction_10618771", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618767" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613301": { "compartment": "compartment_876", "id": "reaction_10613301", "reactome": "R-CEL-204798", "name": "Interaction of Tie2 and p85 of PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602421" ], "products": [ "species_10613299" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "F3NWW5", "WBGene00002195", "Q94125", "WBGene00000090", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5EDP9", "WBGene00000001", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10613325": { "compartment": "compartment_876", "id": "reaction_10613325", "reactome": "R-CEL-204871", "name": "Interaction of Tie2 and Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613255", "species_10602400" ], "products": [ "species_10613323" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "WBGene00004774", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10620439": { "compartment": "compartment_114584", "id": "reaction_10620439", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29372", "species_114565" ], "modifiers": [ [ "species_10620436", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10628226": { "compartment": "compartment_70101", "id": "reaction_10628226", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628152", "species_10628147" ], "products": [ "species_10628154" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10628373": { "compartment": "compartment_7660", "id": "reaction_10628373", "reactome": "R-CEL-1008200", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628369", "species_1008228" ], "products": [ "species_10628371" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521", "P34707", "WBGene00004804", "B0M0M9", "WBGene00077521" ] }, "reaction_10628113": { "compartment": "compartment_70101", "id": "reaction_10628113", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628107", "species_10628102" ], "products": [ "species_10628111" ], "modifiers": [], "additional_components": [ "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P46822", "WBGene00002215" ] }, "reaction_10625054": { "compartment": "compartment_70101", "id": "reaction_10625054", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625050", "species_10625045" ], "products": [ "species_10625052" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292" ] }, "reaction_10623288": { "compartment": "compartment_876", "id": "reaction_10623288", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623154" ], "products": [ "species_10623286" ], "modifiers": [], "additional_components": [ "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708", "P34714", "WBGene00003893", "Q21267", "WBGene00019476", "P54216", "WBGene00011474", "Q9XXE9", "WBGene00016769", "Q23046", "WBGene00020806", "Q18705", "WBGene00016769", "G5EFK8", "WBGene00008779", "P91917", "WBGene00012344", "Q22174", "WBGene00011449", "Q9N413", "WBGene00004249", "Q21265", "WBGene00019478", "Q9XWD6", "WBGene00000415", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "Q95NU5", "WBGene00003870", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "O01764", "WBGene00018157", "Q10651", "WBGene00000149", "Q9XXG5", "WBGene00006598", "G5EE40", "WBGene00005642", "Q23158", "WBGene00000228", "H2KZY5", "WBGene00018533", "Q21154", "WBGene00019333", "G5ECY2", "WBGene00005644", "O45271", "WBGene00006597", "Q09387", "WBGene00019944", "Q18685", "WBGene00006836", "A9Z1L1", "WBGene00005648", "Q9GZE9", "WBGene00017719", "P46563", "WBGene00017166", "O45520", "WBGene00009708" ] }, "reaction_10605543": { "compartment": "compartment_70101", "id": "reaction_10605543", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10605540", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10613779": { "compartment": "compartment_70101", "id": "reaction_10613779", "reactome": "R-CEL-210283", "name": "Interaction of PECAM-1 and PLC gamma1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10612156" ], "products": [ "species_10613777" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004038", "Q22070", "WBGene00004038", "O01761", "WBGene00006820" ] }, "reaction_10613000": { "compartment": "compartment_876", "id": "reaction_10613000", "reactome": "R-CEL-204434", "name": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10612996" ], "products": [ "species_10612998" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10621291": { "compartment": "compartment_70101", "id": "reaction_10621291", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10602421", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10666074": { "compartment": "compartment_984", "id": "reaction_10666074", "reactome": "R-CEL-9708859", "name": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10666070" ], "products": [ "species_10666072", "species_10618735" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10618769": { "compartment": "compartment_70101", "id": "reaction_10618769", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618746", "species_10618763", "species_10610070" ], "products": [ "species_10618767" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "WBGene00005077", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10613800": { "compartment": "compartment_70101", "id": "reaction_10613800", "reactome": "R-CEL-210291", "name": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613783" ], "products": [ "species_29370", "species_10613789" ], "modifiers": [ [ "species_10613791", "catalyst" ] ], "additional_components": [ "O01761", "WBGene00006820", "O01761", "WBGene00006820", "WBGene00005077" ] }, "reaction_10621374": { "compartment": "compartment_70101", "id": "reaction_10621374", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621366", "species_29438" ], "products": [ "species_10621368", "species_29420" ], "modifiers": [ [ "species_10621371", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q03206", "ced-10", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10623417": { "compartment": "compartment_876", "id": "reaction_10623417", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623365" ], "products": [ "species_10623415" ], "modifiers": [], "additional_components": [ "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "CHEBI:15996", "species_111349", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986", "Q23030", "WBGene00019986", "O16454", "WBGene00007055", "Q21267", "WBGene00019476", "Q9U2X1", "WBGene00019986", "species_29370", "Q688B0", "WBGene00019786", "O02108", "WBGene00021097", "species_109496", "species_29420", "species_29372", "Q21265", "WBGene00019478", "O17365", "WBGene00005643", "Q9XVQ1", "WBGene00009708", "species_113541", "Q18740", "WBGene00008231", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "H2L0F2", "WBGene00019497", "species_74016", "G5EE40", "WBGene00005642", "species_29438", "species_114523", "G5ECY2", "WBGene00005644", "A0A1N7SYP5", "WBGene00009500", "species_113592", "A9Z1L1", "WBGene00005648", "Q9XXQ7", "WBGene00019986", "O45520", "WBGene00009708", "Q21810", "WBGene00019986" ] }, "reaction_10628271": { "compartment": "compartment_70101", "id": "reaction_10628271", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628267", "species_10604862" ], "products": [ "species_10628269" ], "modifiers": [], "additional_components": [ "Q10955", "WBGene00004348", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "P30625", "WBGene00002190", "Q10955", "WBGene00004348", "P21137", "WBGene00002189", "Q95XS0", "WBGene00021419", "Q09285", "WBGene00016977", "Q19731", "WBGene00009052" ] }, "reaction_10605796": { "compartment": "compartment_984", "id": "reaction_10605796", "reactome": "R-CEL-141046", "name": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605792", "species_10605556" ], "products": [ "species_10605794" ], "modifiers": [], "additional_components": [ "WBGene00020921", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "G5EBU2", "WBGene00020921", "species_74016" ] }, "reaction_10605559": { "compartment": "compartment_984", "id": "reaction_10605559", "reactome": "R-CEL-114697", "name": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605545" ], "products": [ "species_10605439", "species_10605547" ], "modifiers": [ [ "species_10605556", "catalyst" ] ], "additional_components": [ "WBGene00016570", "WBGene00016570", "WBGene00016570", "Q93518", "WBGene00008879", "species_74016" ] }, "reaction_10613027": { "compartment": "compartment_876", "id": "reaction_10613027", "reactome": "R-CEL-204600", "name": "Basigin homodimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925" ], "products": [ "species_10613025" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10659424": { "compartment": "compartment_12045", "id": "reaction_10659424", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869214", "species_29356" ], "products": [ "species_8869207", "species_29416" ], "modifiers": [ [ "species_10659421", "catalyst" ] ], "additional_components": [ "Q22943", "WBGene00003907", "G5EGT1", "WBGene00003906" ] }, "reaction_10665500": { "compartment": "compartment_17957", "id": "reaction_10665500", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665498" ], "products": [ "species_10623242" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618108": { "compartment": "compartment_876", "id": "reaction_10618108", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605439", "species_10605486" ], "products": [ "species_10605488" ], "modifiers": [], "additional_components": [ "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681" ] }, "reaction_10605492": { "compartment": "compartment_70101", "id": "reaction_10605492", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605488" ], "products": [ "species_29420", "species_10605490" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "G5EGU1", "WBGene00001196", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10644326": { "compartment": "compartment_984", "id": "reaction_10644326", "reactome": "R-CEL-5578883", "name": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10644322", "species_10605556" ], "products": [ "species_10644324" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "Q93518", "WBGene00008879", "species_74016", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10605697": { "compartment": "compartment_984", "id": "reaction_10605697", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605695", "species_9693058" ], "products": [ "species_10605667" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10628243": { "compartment": "compartment_17906", "id": "reaction_10628243", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628237" ], "products": [ "species_10628241" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10612983": { "compartment": "compartment_876", "id": "reaction_10612983", "reactome": "R-CEL-204392", "name": "Basigin binds MCT1, MCT3 and MCT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612973", "species_10612925" ], "products": [ "species_10612981" ], "modifiers": [], "additional_components": [ "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q22109", "WBGene00020168", "O17328", "WBGene00015676", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q9UAT3", "WBGene00015273", "Q93896", "WBGene00010834", "H2KZ60", "WBGene00016354", "Q18712", "WBGene00008214", "H2L0E6", "WBGene00003986" ] }, "reaction_10628232": { "compartment": "compartment_70101", "id": "reaction_10628232", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628170" ], "products": [ "species_10628178" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10638020": { "compartment": "compartment_876", "id": "reaction_10638020", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10638016", "species_10638011" ], "products": [ "species_10638018" ], "modifiers": [], "additional_components": [ "WBGene00008800", "WBGene00009500", "Q19459", "WBGene00008800", "A0A1N7SYP5", "WBGene00009500" ] }, "reaction_10613297": { "compartment": "compartment_984", "id": "reaction_10613297", "reactome": "R-CEL-204779", "name": "Interaction of Tie2 with Ang1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613107" ], "products": [ "species_10613295" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10612243": { "compartment": "compartment_876", "id": "reaction_10612243", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612239", "species_10612233" ], "products": [ "species_10612241" ], "modifiers": [], "additional_components": [ "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "Q9XWD6", "WBGene00000415", "Q23046", "WBGene00020806" ] }, "reaction_10620845": { "compartment": "compartment_70101", "id": "reaction_10620845", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620389" ], "products": [ "species_29370", "species_10609584" ], "modifiers": [ [ "species_10620842", "catalyst" ] ], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "WBGene00005077" ] }, "reaction_10620455": { "compartment": "compartment_876", "id": "reaction_10620455", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620453" ], "products": [ "species_10605540" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10605787": { "compartment": "compartment_984", "id": "reaction_10605787", "reactome": "R-CEL-140872", "name": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605742" ], "products": [ "species_10605785", "species_9693058" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "G5ECY2", "WBGene00005644", "Q93518", "WBGene00008879", "species_74016", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "A9Z1L1", "WBGene00005648", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "LigandDisplayForward?ligandId=6804", "LigandDisplayForward?ligandId=6803", "LigandDisplayForward?ligandId=6846", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214" ] }, "reaction_10621362": { "compartment": "compartment_70101", "id": "reaction_10621362", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621354" ], "products": [ "species_10621356", "species_29420" ], "modifiers": [ [ "species_10621359", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887" ] }, "reaction_10618757": { "compartment": "compartment_70101", "id": "reaction_10618757", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618748" ], "products": [ "species_10618754" ], "modifiers": [ [ "species_10618748", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "H2KZ99", "WBGene00016570", "P39745", "WBGene00003401", "U4PDY6", "WBGene00019665", "P51485", "WBGene00000195" ] }, "reaction_10621249": { "compartment": "compartment_876", "id": "reaction_10621249", "reactome": "R-CEL-435244", "name": "PECAM1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613781" ], "products": [ "species_29370", "species_10613771" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00006820" ] }, "reaction_10605527": { "compartment": "compartment_70101", "id": "reaction_10605527", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605516" ], "products": [ "species_29370", "species_10605524" ], "modifiers": [ [ "species_10605480", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O44412", "WBGene00020298", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10664445": { "compartment": "compartment_984", "id": "reaction_10664445", "reactome": "R-CEL-9603302", "name": "Factor IIa inhibitors (peptide) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603327", "species_10605556" ], "products": [ "species_10664443" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6458", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6458", "Q93518", "WBGene00008879", "species_74016", "LigandDisplayForward?ligandId=6469", "LigandDisplayForward?ligandId=6470" ] }, "reaction_10605745": { "compartment": "compartment_876", "id": "reaction_10605745", "reactome": "R-CEL-140870", "name": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605675" ], "products": [ "species_10605742" ], "modifiers": [ [ "species_10605675", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "LigandDisplayForward?ligandId=6811", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6804", "species_74016", "G5EE40", "WBGene00005642", "LigandDisplayForward?ligandId=6819", "LigandDisplayForward?ligandId=4214", "G5ECY2", "WBGene00005644", "LigandDisplayForward?ligandId=6803", "O17365", "WBGene00005643", "A9Z1L1", "WBGene00005648", "LigandDisplayForward?ligandId=6846", "Q9XVQ1", "WBGene00009708", "O45520", "WBGene00009708", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647" ] }, "reaction_10618765": { "compartment": "compartment_70101", "id": "reaction_10618765", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618761", "species_10618735" ], "products": [ "species_10618763" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10613775": { "compartment": "compartment_70101", "id": "reaction_10613775", "reactome": "R-CEL-210277", "name": "Interaction of PECAM-1 and SHP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613771", "species_10613445" ], "products": [ "species_10613773" ], "modifiers": [], "additional_components": [ "WBGene00006820", "WBGene00004214", "G5EC24", "WBGene00004214", "O01761", "WBGene00006820" ] }, "reaction_10613321": { "compartment": "compartment_984", "id": "reaction_10613321", "reactome": "R-CEL-204863", "name": "Interaction of Tie2 with Ang2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613293", "species_10613317" ], "products": [ "species_10613319" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628426": { "compartment": "compartment_70101", "id": "reaction_10628426", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628420", "species_10628422" ], "products": [ "species_10628424" ], "modifiers": [], "additional_components": [ "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "Q03206", "ced-10", "Q20487", "WBGene00018520", "A0A0K3AR51", "F22G12.5c", "G5EEN3", "WBGene00000419", "O62422", "WBGene00012532" ] }, "reaction_10618744": { "compartment": "compartment_70101", "id": "reaction_10618744", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618740", "species_10618735" ], "products": [ "species_10618742" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10628222": { "compartment": "compartment_70101", "id": "reaction_10628222", "reactome": "R-CEL-983266", "name": "Kinesins bind microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_10628216" ], "products": [ "species_10628218" ], "modifiers": [], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "Q9XU12", "WBGene00002219", "Q965T6", "WBGene00002230", "Q8MQ03", "WBGene00006974", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "G5EEE6", "WBGene00002182", "P34540", "WBGene00006840", "P23678", "WBGene00006831", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "H9G2T2", "WBGene00002214", "G5EBX0", "WBGene00002228", "Q9XUS9", "WBGene00000875", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10663939": { "compartment": "compartment_984", "id": "reaction_10663939", "reactome": "R-CEL-9015379", "name": "Factor IIa inhibitors (compounds) binds IIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9603311", "species_10605556" ], "products": [ "species_10663937" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760", "Q93518", "WBGene00008879", "species_74016", "Q93518", "WBGene00008879", "LigandDisplayForward?ligandId=6382", "LigandDisplayForward?ligandId=6385", "species_74016", "LigandDisplayForward?ligandId=6380", "LigandDisplayForward?ligandId=8760" ] }, "reaction_10605466": { "compartment": "compartment_70101", "id": "reaction_10605466", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10605453" ], "products": [ "species_10605463", "species_29420" ], "modifiers": [ [ "species_10605439", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_111349", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "WBGene00016570" ] }, "reaction_10615894": { "compartment": "compartment_876", "id": "reaction_10615894", "reactome": "R-CEL-375133", "name": "Basigin binds Mannose-carrying cell recognition molecules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612925", "species_10615890" ], "products": [ "species_10615892" ], "modifiers": [], "additional_components": [ "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "Q9XUY5", "WBGene00010117", "Q8MQ86", "WBGene00017184", "Q18806", "WBGene00004370", "Q5WRR1", "WBGene00006942", "H2KZ60", "WBGene00016354" ] }, "reaction_10628291": { "compartment": "compartment_7660", "id": "reaction_10628291", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628287", "species_10628276" ], "products": [ "species_10628289" ], "modifiers": [], "additional_components": [ "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "WBGene00000414", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "P34618", "WBGene00000414" ] }, "reaction_10618114": { "compartment": "compartment_876", "id": "reaction_10618114", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605463" ], "products": [ "species_10618112", "species_10605439", "species_10605064" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "H2KZ99", "WBGene00016570", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "species_29438", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "WBGene00016570", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q20636", "WBGene00001680", "P54406", "WBGene00001681" ] }, "reaction_10628300": { "compartment": "compartment_70101", "id": "reaction_10628300", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628296", "species_10625052" ], "products": [ "species_10628298" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "Q21301", "WBGene00010641" ] }, "reaction_10614187": { "compartment": "compartment_876", "id": "reaction_10614187", "reactome": "R-CEL-210881", "name": "Dimerization of Tie2/Ang1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613295" ], "products": [ "species_10614185" ], "modifiers": [], "additional_components": [ "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10615042": { "compartment": "compartment_161320", "id": "reaction_10615042", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615034" ], "products": [ "species_10615040" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642" ] }, "reaction_10628341": { "compartment": "compartment_7660", "id": "reaction_10628341", "reactome": "R-CEL-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628337", "species_10628314" ], "products": [ "species_10628339" ], "modifiers": [], "additional_components": [ "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "Q9XVG8", "WBGene00012209", "Q9XXU5", "WBGene00000138", "O17695", "WBGene00001834", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278" ] }, "reaction_10621346": { "compartment": "compartment_70101", "id": "reaction_10621346", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10621334" ], "products": [ "species_10621336", "species_29420" ], "modifiers": [ [ "species_10621339", "catalyst" ], [ "species_10621344", "catalyst" ], [ "species_10621342", "inhibitor" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q05062", "WBGene00000390", "Q03206", "ced-10", "O62422", "WBGene00012532", "Q22038", "WBGene00004357", "Q05062", "WBGene00000390", "Q03206", "ced-10", "species_29438", "O62422", "WBGene00012532", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179856" ] }, "reaction_10628396": { "compartment": "compartment_74700", "id": "reaction_10628396", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628392", "species_10628383" ], "products": [ "species_10628394" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "W6SBE5", "WBGene00021538", "G5ECC3", "WBGene00004373" ] }, "reaction_10628220": { "compartment": "compartment_70101", "id": "reaction_10628220", "reactome": "R-CEL-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10628218" ], "products": [ "species_29370", "species_10628218" ], "modifiers": [], "additional_components": [ "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q965T6", "WBGene00002230", "P46873", "WBGene00003884", "G5EGS3", "WBGene00002223", "Q19633", "WBGene00002222", "species_29420", "Q18817", "WBGene00000248", "P34540", "WBGene00006840", "H9G2T2", "WBGene00002214", "P52275", "WBGene00006537", "Q9XUS9", "WBGene00000875", "Q9XU12", "WBGene00002219", "Q8MQ03", "WBGene00006974", "H2L2E8", "WBGene00006528", "O45935", "WBGene00002229", "Q8MQ20", "WBGene00002217", "P46822", "WBGene00002215", "species_29438", "P12456", "WBGene00003171", "P34690", "WBGene00006529", "G5EEE6", "WBGene00002182", "P23678", "WBGene00006831", "P41937", "WBGene00006538", "G5ECF4", "WBGene00000257", "A0A4V0IKG7", "WBGene00002224", "G5EBX0", "WBGene00002228", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539" ] }, "reaction_10628224": { "compartment": "compartment_70101", "id": "reaction_10628224", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628143" ], "products": [ "species_10628145" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10623550": { "compartment": "compartment_876", "id": "reaction_10623550", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623520" ], "products": [ "species_10623548" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491", "Q10651", "WBGene00000149", "Q20707", "WBGene00006630", "Q9N4L6", "WBGene00022836", "Q17526", "WBGene00006637", "O01761", "WBGene00006820", "Q27874", "WBGene00003930", "P91855", "WBGene00009174", "A0A1N7SYP5", "WBGene00009500", "Q9XVM9", "WBGene00006641", "Q9XVI4", "WBGene00006633", "Q17441", "WBGene00006646", "O62466", "WBGene00006631", "G4RWX0", "WBGene00006632", "K8F7Z5", "WBGene00008735", "P34446", "WBGene00003929", "Q5WRN1", "WBGene00023491" ] }, "reaction_10613808": { "compartment": "compartment_876", "id": "reaction_10613808", "reactome": "R-CEL-210304", "name": "Interaction of integrin alphaVbeta3 with PECAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10613781" ], "products": [ "species_10613806" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00006820", "Q27874", "WBGene00003930", "O01761", "WBGene00006820", "P34446", "WBGene00003929" ] }, "reaction_10614191": { "compartment": "compartment_70101", "id": "reaction_10614191", "reactome": "R-CEL-210974", "name": "Interaction of SOS-1 to Tie2 bound Grb2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602405", "species_10613323" ], "products": [ "species_10614189" ], "modifiers": [], "additional_components": [ "WBGene00004947", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745", "F3NWW5", "WBGene00002195", "P29355", "WBGene00004774", "H2KZU7", "WBGene00020504", "Q95ZK1", "WBGene00021745", "A0A2C9C3B4", "WBGene00021745", "Q21868", "WBGene00021745", "Q21046", "WBGene00021745", "Q18163", "WBGene00016104", "Q10656", "WBGene00001184", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "G5ED65", "WBGene00006894", "O17955", "WBGene00002211", "A0A1I6CMA1", "WBGene00021745", "Q23136", "WBGene00021745", "Q21867", "WBGene00021745", "Q17833", "WBGene00003862", "Q9N5D3", "WBGene00004947", "Q23677", "WBGene00003863", "Q9N4T2", "WBGene00021745", "O18008", "WBGene00021745", "Q19238", "WBGene00021745" ] }, "reaction_10628941": { "compartment": "compartment_70101", "id": "reaction_10628941", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628847", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628811" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628943": { "compartment": "compartment_7660", "id": "reaction_10628943", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10628853" ], "products": [ "species_159942", "species_159939", "species_10628909" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628945": { "compartment": "compartment_70101", "id": "reaction_10628945", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628807", "species_10628835" ], "products": [ "species_10628863" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628939": { "compartment": "compartment_70101", "id": "reaction_10628939", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628931" ], "products": [ "species_10628818" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727" ] }, "reaction_10628921": { "compartment": "compartment_7660", "id": "reaction_10628921", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628907", "species_10628917" ], "products": [ "species_10628919" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628866": { "compartment": "compartment_70101", "id": "reaction_10628866", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628861", "species_10628863" ], "products": [ "species_10628859", "species_10628837" ], "modifiers": [ [ "species_10628863", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "G5EBV0", "WBGene00001178", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10628887": { "compartment": "compartment_7660", "id": "reaction_10628887", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628855", "species_113671", "species_113685" ], "products": [ "species_159942", "species_159939", "species_10628874" ], "modifiers": [ [ "species_10628884", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10628934": { "compartment": "compartment_7660", "id": "reaction_10628934", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628927", "species_10628919" ], "products": [ "species_10628931", "species_10628925" ], "modifiers": [ [ "species_10628919", "catalyst" ] ], "additional_components": [ "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "P0CG71", "WBGene00006727", "Q20617", "WBGene00006719", "Q9U1U4", "WBGene00006714", "P35129", "WBGene00002344", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320" ] }, "reaction_10628843": { "compartment": "compartment_70101", "id": "reaction_10628843", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628839" ], "products": [ "species_10597908", "species_10628841" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "P0CG71", "WBGene00006727", "WBGene00006727", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628937": { "compartment": "compartment_70101", "id": "reaction_10628937", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628849", "species_29368", "species_29406" ], "products": [ "species_113528", "species_29434", "species_10628814" ], "modifiers": [ [ "species_10628835", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "Q17390", "WBGene00000837", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "species_113531", "species_198836", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "G5EBV0", "WBGene00001178" ] }, "reaction_10636006": { "compartment": "compartment_161320", "id": "reaction_10636006", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10636003", "catalyst" ] ], "additional_components": [ "O16454", "WBGene00007055", "Q7JKL9", "WBGene00013973", "O01531", "WBGene00017678", "P55956", "WBGene00000216", "O45072", "WBGene00015700", "Q18020", "WBGene00007605", "P52717", "WBGene00018271", "Q8MYN7", "WBGene00012681", "P43510", "WBGene00000786", "O17255", "WBGene00044760", "O01530", "WBGene00000219", "G5EEI4", "WBGene00000214", "Q9BL26", "WBGene00044760", "P52716", "WBGene00017969", "Q86NE0", "WBGene00000215", "P52715", "WBGene00008741", "Q8MYN5", "WBGene00012683", "Q21966", "WBGene00000217", "Q8MYN6", "WBGene00012682", "O76725", "WBGene00021503", "O01532", "WBGene00000218", "P52714", "WBGene00007462", "Q2AAB9", "WBGene00044760", "Q22972", "WBGene00017881", "Q09991", "WBGene00019605", "G5EC01", "WBGene00077655", "U4PME4", "WBGene00044760" ] }, "reaction_10636398": { "compartment": "compartment_161320", "id": "reaction_10636398", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10636395", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10627920": { "compartment": "compartment_70101", "id": "reaction_10627920", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627918" ], "products": [ "species_983123", "species_10627781" ], "modifiers": [], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627946": { "compartment": "compartment_70101", "id": "reaction_10627946", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627851", "species_10627943" ], "products": [ "species_10627853", "species_10627941" ], "modifiers": [ [ "species_10627851", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344" ] }, "reaction_10618106": { "compartment": "compartment_70101", "id": "reaction_10618106", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618102", "species_10615172" ], "products": [ "species_10618104" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10618097": { "compartment": "compartment_70101", "id": "reaction_10618097", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10617231" ], "products": [ "species_10617233" ], "modifiers": [], "additional_components": [ "WBGene00004255", "P34578", "WBGene00004255", "species_30389" ] }, "reaction_10628615": { "compartment": "compartment_876", "id": "reaction_10628615", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10608583" ], "products": [ "species_10607837", "species_29420" ], "modifiers": [ [ "species_10628612", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "P22981", "WBGene00002335", "species_29438", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10617865": { "compartment": "compartment_70101", "id": "reaction_10617865", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10610909", "species_29356" ], "products": [ "species_10617862", "species_29372" ], "modifiers": [ [ "species_10610622", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "A9UJN4", "WBGene00007554", "O18178", "WBGene00012348", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363" ] }, "reaction_10627952": { "compartment": "compartment_70101", "id": "reaction_10627952", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627853", "species_10627859" ], "products": [ "species_10627851", "species_111294", "species_76577", "species_10627918" ], "modifiers": [ [ "species_10627859", "catalyst" ] ], "additional_components": [ "Q9XWF6", "WBGene00006711", "O45495", "WBGene00006730", "Q27481", "WBGene00006699", "P34477", "WBGene00006704", "Q9TZ69", "WBGene00006715", "Q20617", "WBGene00006719", "Q95XX0", "WBGene00006708", "Q18931", "WBGene00006703", "Q9U1U4", "WBGene00006714", "P0CG71", "WBGene00006727", "A0A2K5ATR7", "WBGene00022450", "Q9N2W9", "WBGene00006705", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q17720", "WBGene00006717", "Q95XN7", "WBGene00006702", "Q9U1Q1", "WBGene00006709", "Q93571", "WBGene00006720", "P35129", "WBGene00002344", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", 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"WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627954": { "compartment": "compartment_70101", "id": "reaction_10627954", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00001236", "Q20617", "WBGene00006719", "P34284", "WBGene00015350", "Q93349", "WBGene00007985", "Q9N3G1", "WBGene00021815", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "O62200", "WBGene00018654", "A0A2K5ATR7", "WBGene00022450", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q9U1Q1", "WBGene00006709", "P91404", "WBGene00019993", "O45495", "WBGene00006730", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q2WF61", "WBGene00044345", "Q9N5S5", "WBGene00018654", "Q17720", "WBGene00006717", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "A0A4V0IJV5", "WBGene00021406", "P91133", "WBGene00016326", "Q2AAC0", "WBGene00022168", "G5EG38", "WBGene00001281", "P34441", "WBGene00001284", "Q93903", "WBGene00001583", "Q17911", "WBGene00007529", "Q9U1U4", "WBGene00006714", "Q03607", "WBGene00018654", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q9N373", "WBGene00002278", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "Q17583", "WBGene00007252", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "Q18931", "WBGene00006703", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "A8DJA6", "WBGene00021721" ] }, "reaction_10628074": { "compartment": "compartment_70101", "id": "reaction_10628074", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10628071", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q09541", "WBGene00017686", "Q22531", "WBGene00022073" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_10618070" ], "products": [ "species_10618072" ], "modifiers": [ [ "species_10625485", "inhibitor" ] ], "additional_components": [ "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10627949": { "compartment": "compartment_70101", "id": "reaction_10627949", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627941", "species_29926", "species_10597908" ], "products": [ "species_10627943", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10627941", "catalyst" ] ], "additional_components": [ "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882", "P0CG71", "WBGene00006727", "Q19360", "WBGene00004341", "Q27481", "WBGene00006699", "P91430", "WBGene00020184", "G5EBK4", "WBGene00010882" ] }, "reaction_10628590": { "compartment": "compartment_70101", "id": "reaction_10628590", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_33625", "species_10605468", "species_114519" ], "products": [ "species_10605476" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_1500646", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10625498": { "compartment": "compartment_70101", "id": "reaction_10625498", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618059", "species_113592" ], "products": [ "species_29370", "species_10625485" ], "modifiers": [ [ "species_10625495", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "P21137", "WBGene00002189", "H2KYN2", "WBGene00015650" ] }, "reaction_10612908": { "compartment": "compartment_12045", "id": "reaction_10612908", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612652", "species_10612904" ], "products": [ "species_10612906" ], "modifiers": [], "additional_components": [ "species_29438", "Q23445", "WBGene00022678", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q9U2Z1", "WBGene00004754", "species_29438", "Q23445", "WBGene00022678" ] }, "reaction_10627862": { "compartment": "compartment_70101", "id": "reaction_10627862", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10627855" ], "products": [ "species_10627851", "species_111294", "species_10627859", "species_76577" ], "modifiers": [ [ "species_10627781", "catalyst" ] ], "additional_components": [ "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q9XUS3", "WBGene00003967", "Q95XX0", "WBGene00006708", "Q65XX2", "WBGene00021831", "Q21633", "WBGene00006713", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q09291", "WBGene00009738", "Q9TZ69", "WBGene00006715", "O45323", "WBGene00008439", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q6A590", "WBGene00020884", "Q9N2W9", "WBGene00006705", "Q17750", "WBGene00015555", 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"Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "P0CG71", "WBGene00006727", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320", "A0A0K3AV89", "Y32G9A.6d", "Q9N593", "WBGene00003132", "A0PD34", "WBGene00018654", "Q09563", "WBGene00018563", "G5ECR7", "WBGene00001235", "Q94251", "WBGene00001089", "Q09397", "WBGene00018613", "B1Q249", "WBGene00021721", "Q9XUS3", "WBGene00003967", "O62200", "WBGene00018654", "Q65XX2", "WBGene00021831", "Q17390", "WBGene00000837", "V6CLA2", "WBGene00016405", "Q9GRV5", "WBGene00006616", "Q20874", "WBGene00018964", "Q20183", "WBGene00006415", "Q965X6", "WBGene00021369", "Q965N7", "WBGene00021596", "P90990", "WBGene00015194", "Q09299", "WBGene00017138", "P91404", "WBGene00019993", "G5EFS1", "WBGene00002069", "O17736", "WBGene00008429", "Q9N2Z7", "WBGene00007009", "Q19019", "WBGene00004829", "Q21106", "WBGene00014243", "Q09291", "WBGene00009738", "G5EBJ4", "WBGene00013835", "Q17391", "WBGene00000838", "Q20052", "WBGene00000145", "P34514", "WBGene00000143", "O45323", "WBGene00008439", "G5ECU1", "WBGene00004807", "Q9TYV3", "WBGene00021074", "Q19294", "WBGene00003134", "Q09649", "WBGene00001510", "Q2WF61", "WBGene00044345", "Q6A590", "WBGene00020884", "Q9N5S5", "WBGene00018654", "Q17750", "WBGene00015555", "Q17531", "WBGene00007206", "H2L0L4", "WBGene00020461", "G5ECZ8", "WBGene00003404", "Q19213", "WBGene00006922", "Q17492", "WBGene00007168", "Q9XXE6", "WBGene00003898", "Q9UAQ3", "WBGene00016539", "A0A4V0IJV5", "WBGene00021406", "O62235", "WBGene00009477", "A0A0S4XR36", "C44E4.1d", "P91133", "WBGene00016326", "A0A061ACQ8", "WBGene00022358", "Q965N6", "WBGene00021597", "Q2AAC0", "WBGene00022168", "Q8MQ13", "WBGene00018654", "G5EG38", "WBGene00001281", "O17324", "WBGene00015673", "G5ED84", "WBGene00020952", "P34441", "WBGene00001284", "H8W3Y2", "WBGene00001492", "Q93903", "WBGene00001583", "Q17490", "WBGene00006780", "Q17911", "WBGene00007529", "O18152", "WBGene00012124", "Q03607", "WBGene00018654", "Q9N4I6", "WBGene00022115", "Q22431", "WBGene00020462", "U4PBY0", "WBGene00022069", "O61795", "WBGene00020030", "O18191", "WBGene00003133", "Q9N3T6", "WBGene00021640", "Q17962", "WBGene00007574", "Q17389", "WBGene00000836", "Q09373", "WBGene00001511", "Q22071", "WBGene00003177", "P34638", "WBGene00000863", "Q9N373", "WBGene00002278", "G5EGS4", "WBGene00002184", "Q19214", "WBGene00008588", "O76671", "WBGene00019185", "H2L067", "WBGene00003229", "Q17583", "WBGene00007252", "Q9BKS1", "WBGene00001236", "G5ECY6", "WBGene00000500", "Q9N3F9", "WBGene00021812", "P34284", "WBGene00015350", "P34569", "WBGene00002186", "G5EES6", "WBGene00007333", "Q93349", "WBGene00007985", "Q9BL11", "WBGene00021685", "Q21209", "WBGene00000265", "Q9N3G1", "WBGene00021815", "A8DJA6", "WBGene00021721", "L8E6Y3", "WBGene00016407", "Q23639", "WBGene00000840", "Q23457", "WBGene00004320" ] }, "reaction_10627910": { "compartment": "compartment_17957", "id": "reaction_10627910", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032", "species_113592", "species_29356" ], "products": [ "species_983034", "species_29370", "species_29372" ], "modifiers": [ [ "species_10627907", "catalyst" ] ], "additional_components": [ "O18227", "WBGene00001818", "Q9TZD9", "WBGene00001814", "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O44897", "WBGene00001819" ] }, "reaction_10627922": { "compartment": "compartment_70101", "id": "reaction_10627922", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_983036", "species_8942986", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10628040": { "compartment": "compartment_17957", "id": "reaction_10628040", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10628037", "catalyst" ] ], "additional_components": [ "Q22317", "WBGene00011587", "Q9XVV9", "WBGene00022073", "H2L0M5", "WBGene00022073", "A5A631", "WBGene00022073", "P46557", "WBGene00007139", "Q9NAA0", "WBGene00022073", "Q17405", "WBGene00022073", "Q9U2H2", "WBGene00022073", "Q4TT88", "WBGene00003914", "G5EGH4", "WBGene00022073", "Q22531", "WBGene00022073" ] }, "reaction_10618074": { "compartment": "compartment_70101", "id": "reaction_10618074", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615172" ], "products": [ "species_10615247", "species_111294" ], "modifiers": [ [ "species_10618061", "catalyst" ], [ "species_10618072", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_29420", "Q18246", "WBGene00004307", "H2L055", "WBGene00018734", "H2L2C2", "WBGene00012100", "Q20655", "WBGene00001502", "H2L055", "WBGene00018734", "P41932", "WBGene00003920" ] }, "reaction_10633105": { "compartment": "compartment_876", "id": "reaction_10633105", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633263": { "compartment": "compartment_876", "id": "reaction_10633263", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633260", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "species_74016", "G5EDP9", "WBGene00000001", "species_266099", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10659805": { "compartment": "compartment_20699", "id": "reaction_10659805", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614984", "species_10659801", "species_1806217" ], "products": [ "species_10659803" ], "modifiers": [], "additional_components": [ "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806217", "Q9BKS2", "WBGene00022347", "G5EFK4", "WBGene00000183" ] }, "reaction_10656373": { "compartment": "compartment_70101", "id": "reaction_10656373", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656346", "species_10633219" ], "products": [ "species_10656371" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633324": { "compartment": "compartment_876", "id": "reaction_10633324", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633290": { "compartment": "compartment_876", "id": "reaction_10633290", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10633287", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10656350": { "compartment": "compartment_70101", "id": "reaction_10656350", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656341", "species_10656346" ], "products": [ "species_10656348" ], "modifiers": [], "additional_components": [ "F53A2.8a", "WBGene00003479", "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633206": { "compartment": "compartment_876", "id": "reaction_10633206", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10633203", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10656378": { "compartment": "compartment_876", "id": "reaction_10656378", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633035": { "compartment": "compartment_876", "id": "reaction_10633035", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633224": { "compartment": "compartment_876", "id": "reaction_10633224", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633221", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633132": { "compartment": "compartment_876", "id": "reaction_10633132", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10633316": { "compartment": "compartment_876", "id": "reaction_10633316", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10633313", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10633243": { "compartment": "compartment_876", "id": "reaction_10633243", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10633240", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001" ] }, "reaction_10656381": { "compartment": "compartment_876", "id": "reaction_10656381", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10656375", "catalyst" ] ], "additional_components": [ "Q965W9", "WBGene00003479", "G5ED68", "F53A2.8a" ] }, "reaction_10633282": { "compartment": "compartment_876", "id": "reaction_10633282", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10633030", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10633311": { "compartment": "compartment_876", "id": "reaction_10633311", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633293": { "compartment": "compartment_876", "id": "reaction_10633293", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10611220", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10633080": { "compartment": "compartment_876", "id": "reaction_10633080", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10633213": { "compartment": "compartment_876", "id": "reaction_10633213", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10633129", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10605252": { "compartment": "compartment_7660", "id": "reaction_10605252", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605235" ], "products": [ "species_10601853", "species_10605250" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605237": { "compartment": "compartment_7660", "id": "reaction_10605237", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605233", "species_10605191", "species_10605151", "species_10605168", "species_10601853", "species_10605156", "species_10605228", "species_10605223" ], "products": [ "species_10605235" ], "modifiers": [], "additional_components": [ "WBGene00001259", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "Q9U3I0", "WBGene00009078", "Q9N554", "WBGene00021281", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "P34425", "WBGene00000507", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q9TVL3", "WBGene00000410", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00012000", "WBGene00008729", "P90783", "WBGene00008338", "G5EBY0", "WBGene00009103", "Q17431", "WBGene00007110", "A5Z2V7", "WBGene00008533", "Q9N5U5", "WBGene00018064", "Q03560", "WBGene00007184", "Q9N3L2", "WBGene00021752", "Q21338", "WBGene00005015", "O17869", "WBGene00009650", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "A5Z2V7", "WBGene00008533", "G5ECR7", "WBGene00001235", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q09413", "WBGene00010990", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N4U0", "WBGene00021714", "Q9N554", "WBGene00021281", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9N5R9", "WBGene00018849", "Q9TVL3", "WBGene00000410", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10605248": { "compartment": "compartment_7660", "id": "reaction_10605248", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10605131", "species_10599967" ], "products": [ "species_10605241", "species_10601853" ], "modifiers": [ [ "species_10605131", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O01763", "WBGene00018156", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "WBGene00009479" ] }, "reaction_10605284": { "compartment": "compartment_7660", "id": "reaction_10605284", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10605250" ], "products": [ "species_9757634", "species_10605262" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605126", "species_10605241" ], "products": [ "species_10605243" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q9U3I0", "WBGene00009078", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605266": { "compartment": "compartment_7660", "id": "reaction_10605266", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605262" ], "products": [ "species_10605264" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602928": { "compartment": "compartment_70101", "id": "reaction_10602928", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10602925", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611542": { "compartment": "compartment_70101", "id": "reaction_10611542", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611530" ], "products": [ "species_29370", "species_10611537" ], "modifiers": [ [ "species_10611539", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "H2L0M0", "WBGene00004076", "species_266099", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10611550": { "compartment": "compartment_17927", "id": "reaction_10611550", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10611547", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10606867": { "compartment": "compartment_876", "id": "reaction_10606867", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_83910", "species_30235" ], "modifiers": [ [ "species_10606864", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660206": { "compartment": "compartment_70101", "id": "reaction_10660206", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10611530", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10611457": { "compartment": "compartment_70616", "id": "reaction_10611457", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10611454", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10645970": { "compartment": "compartment_13949", "id": "reaction_10645970", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10645966", "species_10644752" ], "products": [ "species_10645968" ], "modifiers": [], "additional_components": [ "species_29438", "O01803", "WBGene00004274", "WBGene00010045", "Q20759", "WBGene00010045", "species_29438", "O01803", "WBGene00004274" ] }, "reaction_10640972": { "compartment": "compartment_876", "id": "reaction_10640972", "reactome": "R-CEL-4088218", "name": "Tetrastatin binds integrin alphaVbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10630428" ], "products": [ "species_10640970" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614491": { "compartment": "compartment_984", "id": "reaction_10614491", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614485", "species_10614487" ], "products": [ "species_10614489" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614512": { "compartment": "compartment_984", "id": "reaction_10614512", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614477", "species_10614508" ], "products": [ "species_10614510" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10640917": { "compartment": "compartment_876", "id": "reaction_10640917", "reactome": "R-CEL-4085083", "name": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640889", "species_10640891" ], "products": [ "species_10640915" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00001263", "P17139", "WBGene00001263", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614720": { "compartment": "compartment_984", "id": "reaction_10614720", "reactome": "R-CEL-265426", "name": "Interaction of integrin alphaVbeta3 with Tenascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613804", "species_10614506" ], "products": [ "species_10614718" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10614895": { "compartment": "compartment_984", "id": "reaction_10614895", "reactome": "R-CEL-349593", "name": "Interaction of integrin alphaIIbbeta3 with Fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10605504" ], "products": [ "species_10614893" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10623717": { "compartment": "compartment_5460", "id": "reaction_10623717", "reactome": "R-CEL-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113552", "species_113557" ], "modifiers": [ [ "species_10623712", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10598702": { "compartment": "compartment_70101", "id": "reaction_10598702", "reactome": "R-CEL-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10598697", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10619814": { "compartment": "compartment_70101", "id": "reaction_10619814", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10619801", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910" ] }, "reaction_10631293": { "compartment": "compartment_7660", "id": "reaction_10631293", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10611173", "species_10607873" ], "products": [ "species_10631291" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "O16850", "WBGene00000912", "P45897", "WBGene00004858" ] }, "reaction_10622295": { "compartment": "compartment_876", "id": "reaction_10622295", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622293" ], "products": [ "species_10622291", "species_10622230" ], "modifiers": [], "additional_components": [ "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "Q17446", "WBGene00004055", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "P03949", "WBGene00000018", "P90947", "WBGene00001978", "O44326", "WBGene00001979", "Q53U87", "WBGene00004732", "species_29438", "P34609", "WBGene00006755", "O62422", "WBGene00012532", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10622324": { "compartment": "compartment_7660", "id": "reaction_10622324", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622320", "species_10622241" ], "products": [ "species_10622322" ], "modifiers": [], "additional_components": [ "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "Q9U325", "WBGene00003182", "Q9U325", "WBGene00003182", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948" ] }, "reaction_10615948": { "compartment": "compartment_876", "id": "reaction_10615948", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615942", "species_10615944" ], "products": [ "species_10615946" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10622246": { "compartment": "compartment_7660", "id": "reaction_10622246", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622214", "species_10622230" ], "products": [ "species_113582", "species_10622243" ], "modifiers": [ [ "species_10622230", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "O44514", "WBGene00004057", "Q17446", "WBGene00004055" ] }, "reaction_10666234": { "compartment": "compartment_17957", "id": "reaction_10666234", "reactome": "R-CEL-9737780", "name": "MTTP binds lomitapide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9737774", "species_10666230" ], "products": [ "species_10666232" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "CHEBI:16247", "species_171126", "G5ECG7", "WBGene00001099", "Q17770", "WBGene00003963", "CHEBI:16247", "species_9737774", "species_171126", "G5ECG7", "WBGene00001099" ] }, "reaction_10659889": { "compartment": "compartment_7660", "id": "reaction_10659889", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659881" ], "products": [ "species_10659887" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659903": { "compartment": "compartment_20699", "id": "reaction_10659903", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659901" ], "products": [ "species_10659897" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10659885": { "compartment": "compartment_20699", "id": "reaction_10659885", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659879" ], "products": [ "species_10659881", "species_10659883" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10637200": { "compartment": "compartment_984", "id": "reaction_10637200", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10631810" ], "products": [ "species_10637198" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "WBGene00001403", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "O77469", "WBGene00001403" ] }, "reaction_10660724": { "compartment": "compartment_70101", "id": "reaction_10660724", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10660721", "catalyst" ] ], "additional_components": [ "O45719", "WBGene00021956", "Q95XV3", "WBGene00021956" ] }, "reaction_10663928": { "compartment": "compartment_70101", "id": "reaction_10663928", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10663931": { "compartment": "compartment_70101", "id": "reaction_10663931", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10663925", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627109": { "compartment": "compartment_70101", "id": "reaction_10627109", "reactome": "R-CEL-977348", "name": "PHGDH tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728", "species_29360" ], "products": [ "species_70106", "species_73473", "species_977329" ], "modifiers": [ [ "species_10627106", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10664421": { "compartment": "compartment_70101", "id": "reaction_10664421", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10663925", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10627088": { "compartment": "compartment_70101", "id": "reaction_10627088", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10627085", "catalyst" ] ], "additional_components": [ "species_109496", "A0A061ACK7", "WBGene00013379" ] }, "reaction_10627099": { "compartment": "compartment_70101", "id": "reaction_10627099", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10627096", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10635804": { "compartment": "compartment_70101", "id": "reaction_10635804", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635794" ], "products": [ "species_10635802" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10644304": { "compartment": "compartment_7660", "id": "reaction_10644304", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614288", "species_10599971", "species_10644300" ], "products": [ "species_10644302" ], "modifiers": [], "additional_components": [ "P09588", "WBGene00001877", "Q27894", "WBGene00001878", "Q27876", "WBGene00001922", "Q27485", "WBGene00001909", "Q27484", "WBGene00001915", "Q27511", "WBGene00019947", "Q10453", "WBGene00001945", "Q27490", "WBGene00001944", "K7ZUH9", "WBGene00001914", "Q23429", "WBGene00014240", "P04255", "WBGene00001885", "P62784", "WBGene00001875", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9N585", "WBGene00004094", "O02092", "WBGene00018391", "O61931", "WBGene00019971", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q27484", "WBGene00001915", "O62275", "WBGene00010263", "Q9N5K2", "WBGene00019246", "P04255", "WBGene00001885", "Q09249", "WBGene00007624", "P09588", "WBGene00001877", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q27485", "WBGene00001909", "H2KZD5", "WBGene00017641", "Q27511", "WBGene00019947", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q10453", "WBGene00001945", "Q9XVI3", "WBGene00011945", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "Q9U3I0", "WBGene00009078", "O16720", "WBGene00000106", "Q27894", "WBGene00001878", "Q17684", "WBGene00007355", "Q27490", "WBGene00001944", "G5ED77", "WBGene00011910", "K7ZUH9", "WBGene00001914", "A0A0U1RML5", "WBGene00018921", "Q19826", "WBGene00017830", "Q21770", "WBGene00011061", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q93338", "WBGene00007971", "Q27876", "WBGene00001922", "Q21691", "WBGene00019862", "G5EEH0", "WBGene00004323", "Q23429", "WBGene00014240", "P62784", "WBGene00001875" ] }, "reaction_10619797": { "compartment": "compartment_70101", "id": "reaction_10619797", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10612563" ], "products": [ "species_10619794" ], "modifiers": [ [ "species_10612563", "catalyst" ] ], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10635806": { "compartment": "compartment_70101", "id": "reaction_10635806", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619794" ], "products": [ "species_10635794" ], "modifiers": [], "additional_components": [ "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449", "O16720", "WBGene00000106", "Q9N585", "WBGene00004094", "O61931", "WBGene00019971", "G5ED77", "WBGene00011910", "O62275", "WBGene00010263", "A0A0U1RML5", "WBGene00018921", "Q21770", "WBGene00011061", "Q09249", "WBGene00007624", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "Q86NJ8", "WBGene00004093", "Q21691", "WBGene00019862", "H2KZD5", "WBGene00017641", "G5EEH0", "WBGene00004323", "D9N120", "WBGene00022877", "A0A0T7CIX3", "WBGene00019666", "Q9XVI3", "WBGene00011945", "G5EBF5", "WBGene00004326", "Q9TXN7", "WBGene00020707", "P34681", "WBGene00006449" ] }, "reaction_10664156": { "compartment": "compartment_70101", "id": "reaction_10664156", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10635780" ], "products": [ "species_10664153" ], "modifiers": [ [ "species_10635780", "catalyst" ] ], "additional_components": [ "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910", "G5ED77", "WBGene00011910" ] }, "reaction_10632756": { "compartment": "compartment_70101", "id": "reaction_10632756", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10632750", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10632730": { "compartment": "compartment_70101", "id": "reaction_10632730", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10632727", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10644851": { "compartment": "compartment_70101", "id": "reaction_10644851", "reactome": "R-CEL-5618328", "name": "ATAT acetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616991", "species_76183" ], "products": [ "species_76194", "species_10644843" ], "modifiers": [ [ "species_10644848", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00003178" ] }, "reaction_10644854": { "compartment": "compartment_70101", "id": "reaction_10644854", "reactome": "R-CEL-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10644843" ], "products": [ "species_10616991", "species_76183" ], "modifiers": [ [ "species_10643031", "catalyst" ] ], "additional_components": [ "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "species_29420", "P34690", "WBGene00006529", "O18154", "WBGene00006533", "G5EDD4", "WBGene00006530", "Q18817", "WBGene00000248", "P41937", "WBGene00006538", "H2L2E8", "WBGene00006528", "species_29438", "P52275", "WBGene00006537", "O17921", "WBGene00006536", "G5EF01", "WBGene00006539", "P12456", "WBGene00003171", "WBGene00001838" ] }, "reaction_10633770": { "compartment": "compartment_7660", "id": "reaction_10633770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633646": { "compartment": "compartment_7660", "id": "reaction_10633646", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633666": { "compartment": "compartment_7660", "id": "reaction_10633666", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633767": { "compartment": "compartment_7660", "id": "reaction_10633767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633669": { "compartment": "compartment_7660", "id": "reaction_10633669", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633773": { "compartment": "compartment_7660", "id": "reaction_10633773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10633643", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10633591": { "compartment": "compartment_7660", "id": "reaction_10633591", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10633588", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10633761": { "compartment": "compartment_7660", "id": "reaction_10633761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633540": { "compartment": "compartment_7660", "id": "reaction_10633540", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10633626": { "compartment": "compartment_7660", "id": "reaction_10633626", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10633537", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10598876": { "compartment": "compartment_70101", "id": "reaction_10598876", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10598873", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10614940": { "compartment": "compartment_70101", "id": "reaction_10614940", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598873", "species_10614932" ], "products": [ "species_10614938" ], "modifiers": [], "additional_components": [ "WBGene00003844", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844" ] }, "reaction_10605806": { "compartment": "compartment_17951", "id": "reaction_10605806", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141349", "species_141343", "species_113535" ], "products": [ "species_141350", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10614952": { "compartment": "compartment_70101", "id": "reaction_10614952", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10614949", "catalyst" ] ], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615022": { "compartment": "compartment_70101", "id": "reaction_10615022", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10615019", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10615014": { "compartment": "compartment_70101", "id": "reaction_10615014", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10615011", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10615168": { "compartment": "compartment_70101", "id": "reaction_10615168", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614938" ], "products": [ "species_10614932" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "WBGene00022748", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10614964": { "compartment": "compartment_70101", "id": "reaction_10614964", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614958", "species_10614938" ], "products": [ "species_10614962" ], "modifiers": [], "additional_components": [ "O01579", "WBGene00018764", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "Q9NHZ6", "WBGene00022748", "O01579", "WBGene00018764", "P41931", "WBGene00003844" ] }, "reaction_10615006": { "compartment": "compartment_70101", "id": "reaction_10615006", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10615004": { "compartment": "compartment_70101", "id": "reaction_10615004", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10615001", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10605808": { "compartment": "compartment_17951", "id": "reaction_10605808", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_141323", "species_113535" ], "products": [ "species_141324", "species_113575", "species_141327" ], "modifiers": [ [ "species_10605803", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10633102": { "compartment": "compartment_172574", "id": "reaction_10633102", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10633226": { "compartment": "compartment_172574", "id": "reaction_10633226", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10633246": { "compartment": "compartment_172574", "id": "reaction_10633246", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10633099", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475", "G5ED68", "F53A2.8a" ] }, "reaction_10665730": { "compartment": "compartment_7660", "id": "reaction_10665730", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608179", "species_10598178", "species_10598168", "species_10598173", "species_10598163" ], "products": [ "species_10608181" ], "modifiers": [], "additional_components": [ "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915", "WBGene00004338", "WBGene00004340", "WBGene00004339", "WBGene00018409", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q22664", "WBGene00011915" ] }, "reaction_10665732": { "compartment": "compartment_7660", "id": "reaction_10665732", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608167", "species_10608177", "species_10608172" ], "products": [ "species_10608179" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q21350", "WBGene00010676", "O44992", "WBGene00019595", "Q22664", "WBGene00011915" ] }, "reaction_10647775": { "compartment": "compartment_7660", "id": "reaction_10647775", "reactome": "R-CEL-5684081", "name": "MRN complex binds CDK2 and RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10647722", "species_10597866", "species_10647771" ], "products": [ "species_10647773" ], "modifiers": [], "additional_components": [ "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648902": { "compartment": "compartment_7660", "id": "reaction_10648902", "reactome": "R-CEL-5693608", "name": "Initial resection of double-strand break ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648899", "species_113518" ], "products": [ "species_30555", "species_10648080" ], "modifiers": [ [ "species_10648899", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647796": { "compartment": "compartment_7660", "id": "reaction_10647796", "reactome": "R-CEL-5684140", "name": "ATM phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647783" ], "products": [ "species_113582", "species_10647793" ], "modifiers": [ [ "species_10647783", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296" ] }, "reaction_10647786": { "compartment": "compartment_7660", "id": "reaction_10647786", "reactome": "R-CEL-5684096", "name": "CDK2 phosphorylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10647773" ], "products": [ "species_113582", "species_10647783", "species_10597866" ], "modifiers": [ [ "species_10647773", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "O61847", "WBGene00019362", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "O61847", "WBGene00019362", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863" ] }, "reaction_10648089": { "compartment": "compartment_7660", "id": "reaction_10648089", "reactome": "R-CEL-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648082" ], "products": [ "species_30555", "species_10648086" ], "modifiers": [ [ "species_10648082", "catalyst" ] ], "additional_components": [ "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "O18017", "WBGene00001865", "Q23255", "WBGene00003405", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "Q9TYU5", "WBGene00007029", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648084": { "compartment": "compartment_7660", "id": "reaction_10648084", "reactome": "R-CEL-5685985", "name": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648026", "species_10648033", "species_10648080" ], "products": [ "species_10648082" ], "modifiers": [], "additional_components": [ "Q9U3F2", "WBGene00001016", "O18017", "WBGene00001865", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "WBGene00001049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9TYU5", "WBGene00007029", "Q9N3Q4", "WBGene00000227", "O44199", "WBGene00004296", "Q9U3F2", "WBGene00001016", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O18017", "WBGene00001865", "Q9TYU5", "WBGene00007029", "O62245", "WBGene00009731", "P91399", "WBGene00019712", "O61660", "WBGene00006596", "Q19546", "WBGene00006944", "Q9N3Q4", "WBGene00000227", "O62217", "WBGene00001049", "O44199", "WBGene00004296" ] }, "reaction_10648074": { "compartment": "compartment_7660", "id": "reaction_10648074", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10648066" ], "products": [ "species_427498", "species_427497", "species_10647771" ], "modifiers": [ [ "species_10648071", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10605272": { "compartment": "compartment_7660", "id": "reaction_10605272", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605124", "species_10603872" ], "products": [ "species_10605126" ], "modifiers": [], "additional_components": [ "WBGene00005014", "WBGene00005015", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014" ] }, "reaction_10605282": { "compartment": "compartment_7660", "id": "reaction_10605282", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605254" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605274": { "compartment": "compartment_7660", "id": "reaction_10605274", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605173", "species_10605178" ], "products": [ "species_10605180" ], "modifiers": [], "additional_components": [ "WBGene00001236", "WBGene00001235", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236" ] }, "reaction_10605280": { "compartment": "compartment_7660", "id": "reaction_10605280", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605245" ], "products": [ "species_10605245" ], "modifiers": [], "additional_components": [ "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q21338", "WBGene00005015", "Q95QG8", "WBGene00009479", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9TZ93", "WBGene00005014", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10602932": { "compartment": "compartment_7660", "id": "reaction_10602932", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602930" ], "products": [ "species_10599973", "species_110068", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605286": { "compartment": "compartment_7660", "id": "reaction_10605286", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602944": { "compartment": "compartment_7660", "id": "reaction_10602944", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602934" ], "products": [ "species_10602942" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "O02092", "WBGene00018391", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "O44625", "WBGene00004136", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "O45784", "WBGene00006391", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384" ] }, "reaction_10605268": { "compartment": "compartment_7660", "id": "reaction_10605268", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605161", "species_10605166" ], "products": [ "species_10605168" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849" ] }, "reaction_10605288": { "compartment": "compartment_7660", "id": "reaction_10605288", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10602069": { "compartment": "compartment_7660", "id": "reaction_10602069", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602067" ], "products": [ "species_10599973", "species_109877", "species_10601975", "species_10602053", "species_10601853", "species_10602065", "species_10601970" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q9NEX2", "WBGene00013736", "O61707", "WBGene00006385", "G5EG49", "WBGene00013998", "O44625", "WBGene00004136", "O02092", "WBGene00018391", "O45784", "WBGene00006391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q19826", "WBGene00017830", "O16991", "WBGene00006648", "Q9TYN3", "WBGene00006383", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "WBGene00006648", "O61707", "WBGene00006385", "O45784", "WBGene00006391", "Q95ZS0", "WBGene00006392", "Q17957", "WBGene00006397", "Q9TYN3", "WBGene00006383", "Q9NEW8", "WBGene00006389", "E9P861", "WBGene00006384", "G5EGM3", "WBGene00006382", "G5EF68", "WBGene00006386", "Q18265", "WBGene00016173", "Q20788", "WBGene00006388", "P32085", "WBGene00006542", "Q9GZI6", "WBGene00006387", "Q20361", "WBGene00006395", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "Q9NEX2", "WBGene00013736", "O44625", "WBGene00004136" ] }, "reaction_10605276": { "compartment": "compartment_7660", "id": "reaction_10605276", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605180", "species_10605185" ], "products": [ "species_10605191" ], "modifiers": [], "additional_components": [ "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "WBGene00010990", "G5ECR7", "WBGene00001235", "Q9BKS1", "WBGene00001236", "Q09413", "WBGene00010990" ] }, "reaction_10603082": { "compartment": "compartment_7660", "id": "reaction_10603082", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603080" ], "products": [ "species_10599973", "species_75897", "species_10601853", "species_10602065" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "G5EG49", "WBGene00013998", "O02092", "WBGene00018391", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q17558", "WBGene00015296", "G5EG47", "WBGene00010054", "Q9U3I0", "WBGene00009078", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q17558", "WBGene00015296", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998" ] }, "reaction_10605270": { "compartment": "compartment_7660", "id": "reaction_10605270", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605107", "species_10605093" ], "products": [ "species_10605109" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "P34425", "WBGene00000507", "WBGene00000410", "O17869", "WBGene00009650", "P34425", "WBGene00000507", "Q9TVL3", "WBGene00000410" ] }, "reaction_10605256": { "compartment": "compartment_7660", "id": "reaction_10605256", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605254" ], "products": [ "species_10605250" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974" ] }, "reaction_10605260": { "compartment": "compartment_7660", "id": "reaction_10605260", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605250" ], "products": [ "species_10605258" ], "modifiers": [], "additional_components": [ "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "species_9757634", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "P52652", "WBGene00012000", "Q17558", "WBGene00015296", "P41848", "WBGene00001974", "O17869", "WBGene00009650", "Q21338", "WBGene00005015", "A5Z2V7", "WBGene00008533", "Q95QG8", "WBGene00009479", "G5ECR7", "WBGene00001235", "O02092", "WBGene00018391", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q9TXQ9", "WBGene00017011", "Q9N5K2", "WBGene00019246", "Q19375", "WBGene00008729", "Q17431", "WBGene00007110", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "Q9TZ93", "WBGene00005014", "Q09413", "WBGene00010990", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "G5EBY0", "WBGene00009103", "Q9N554", "WBGene00021281", "Q17684", "WBGene00007355", "Q9BKS1", "WBGene00001236", "Q03560", "WBGene00007184", "P34425", "WBGene00000507", "Q19826", "WBGene00017830", "P34703", "WBGene00001259", "Q9TVL3", "WBGene00000410", "Q9N5R9", "WBGene00018849", "P90783", "WBGene00008338", "Q93338", "WBGene00007971", "Q9N5U5", "WBGene00018064", "Q17558", "WBGene00015296", "P52652", "WBGene00012000", "P41848", "WBGene00001974" ] }, "reaction_10614605": { "compartment": "compartment_984", "id": "reaction_10614605", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10614602", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10613943": { "compartment": "compartment_984", "id": "reaction_10613943", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10613940", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "O01661", "WBGene00000368", "P34374", "WBGene00006772", "A0A3B1E663", "WBGene00006742", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10658294": { "compartment": "compartment_12045", "id": "reaction_10658294", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10658288" ], "products": [ "species_10658292" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10658322": { "compartment": "compartment_70101", "id": "reaction_10658322", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10648879" ], "products": [ "species_10658320" ], "modifiers": [], "additional_components": [ "species_163579", "CHEBI:16247", "species_171126", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_163579", "CHEBI:16247", "species_171126", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992" ] }, "reaction_10634349": { "compartment": "compartment_12045", "id": "reaction_10634349", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10634342" ], "products": [ "species_159751", "species_10634346", "species_1650769" ], "modifiers": [ [ "species_10634340", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10634558": { "compartment": "compartment_984", "id": "reaction_10634558", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634519" ], "products": [ "species_10630807" ], "modifiers": [ [ "species_10634551", "catalyst" ], [ "species_10634556", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "O61901", "WBGene00020954", "Q20176", "WBGene00003555", "O61901", "WBGene00020954" ] }, "reaction_10634538": { "compartment": "compartment_984", "id": "reaction_10634538", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10634443" ], "products": [ "species_10634519" ], "modifiers": [ [ "species_10634535", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q09457", "WBGene00000251", "O62432", "WBGene00001066", "Q20176", "WBGene00003555", "Q19791", "WBGene00001650" ] }, "reaction_10634367": { "compartment": "compartment_17957", "id": "reaction_10634367", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10634360" ], "products": [ "species_10634364", "species_158602" ], "modifiers": [ [ "species_10634360", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10606608": { "compartment": "compartment_7660", "id": "reaction_10606608", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606604" ], "products": [ "species_10606606" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10606694": { "compartment": "compartment_70101", "id": "reaction_10606694", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606606" ], "products": [ "species_10606604" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10665614": { "compartment": "compartment_70101", "id": "reaction_10665614", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10614140": { "compartment": "compartment_984", "id": "reaction_10614140", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10614137", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10598798": { "compartment": "compartment_70101", "id": "reaction_10598798", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_31633" ], "products": [ "species_29370", "species_29472", "species_29372" ], "modifiers": [ [ "species_10598795", "catalyst" ] ], "additional_components": [ "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603", "Q9U307", "WBGene00001604", "Q95YD1", "WBGene00001602", "O02225", "WBGene00001607" ] }, "reaction_10636583": { "compartment": "compartment_70101", "id": "reaction_10636583", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731226", "species_29356" ], "products": [ "species_70106", "species_9731235", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636540": { "compartment": "compartment_70101", "id": "reaction_10636540", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10636537", "catalyst" ] ], "additional_components": [ "species_109496", "O61902", "WBGene00003579" ] }, "reaction_10636577": { "compartment": "compartment_70101", "id": "reaction_10636577", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9731304" ], "products": [ "species_70106", "species_9731298", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636580": { "compartment": "compartment_70101", "id": "reaction_10636580", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9731300", "species_29356" ], "products": [ "species_70106", "species_9731296", "species_29372" ], "modifiers": [ [ "species_10636574", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10636550": { "compartment": "compartment_5460", "id": "reaction_10636550", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_159448", "species_2393950" ], "modifiers": [ [ "species_10636547", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_109496" ] }, "reaction_10625790": { "compartment": "compartment_70101", "id": "reaction_10625790", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625786", "species_10625769" ], "products": [ "species_10625788", "species_10625767" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542" ] }, "reaction_10625798": { "compartment": "compartment_876", "id": "reaction_10625798", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625796", "species_10625767" ], "products": [ "species_10625794", "species_10625769" ], "modifiers": [], "additional_components": [ "Q17796", "WBGene00004101", "species_179838", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q4R133", "WBGene00044542", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9NA26", "WBGene00013598", "O44158", "WBGene00016990", "Q17687", "WBGene00015508", "O76258", "WBGene00015658", "species_179838", "Q8WTK0", "WBGene00021771", "P0CG71", "WBGene00006727", "Q4R133", "WBGene00044542" ] }, "reaction_10625792": { "compartment": "compartment_70101", "id": "reaction_10625792", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625788", "species_10625721" ], "products": [ "species_10625727", "species_10625786" ], "modifiers": [], "additional_components": [ "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193", "species_179838", "P0CG71", "WBGene00006727", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "Q9U2F6", "WBGene00012903", "Q9BL60", "WBGene00022027", "Q9GYK4", "WBGene00020866", "Q22718", "WBGene00011976", "species_179838", "Q21959", "WBGene00020025", "Q18886", "WBGene00016961", "O02208", "WBGene00007216", "P0CG71", "WBGene00006727", "Q18258", "WBGene00016167", "Q19519", "WBGene00008919", "Q9U354", "WBGene00012193" ] }, "reaction_10617081": { "compartment": "compartment_984", "id": "reaction_10617081", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617006" ], "products": [ "species_10614130", "species_10614132", "species_10617004", "species_10614086", "species_10613945", "species_10614116", "species_380873", "species_10614053", "species_10615845" ], "modifiers": [ [ "species_10617006", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10643190": { "compartment": "compartment_70101", "id": "reaction_10643190", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617022", "species_10617017", "species_10617012" ], "products": [ "species_10617028" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615848": { "compartment": "compartment_984", "id": "reaction_10615848", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615843" ], "products": [ "species_10614130", "species_10614132", "species_10613945", "species_10614086", "species_10614116", "species_10614053", "species_374935", "species_10615845" ], "modifiers": [ [ "species_10615843", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34693", "WBGene00004921", "O16700", "WBGene00004925", "WBGene00004267", "WBGene00006757", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "P34351", "WBGene00004899", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "WBGene00022271", "WBGene00000295", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10655657": { "compartment": "compartment_161320", "id": "reaction_10655657", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10655654", "catalyst" ] ], "additional_components": [ "CHEBI:71464", "CHEBI:85262", "CHEBI:71466", "CHEBI:85263", "CHEBI:85299", "species_5693752", "CHEBI:16196", "CHEBI:30805", "species_8934421", "species_422506", "species_390435", "CHEBI:28875", "Q9GUI1", "WBGene00021917" ] }, "reaction_10615853": { "compartment": "compartment_876", "id": "reaction_10615853", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10614086", "species_10613945", "species_10614053", "species_10614048", "species_10615841" ], "products": [ "species_10615843" ], "modifiers": [ [ "species_10615841", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "species_374935", "P27715", "WBGene00006752", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "species_374935", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267" ] }, "reaction_10617030": { "compartment": "compartment_70101", "id": "reaction_10617030", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614058", "species_10617004", "species_10614086", "species_10613945", "species_10616993", "species_10614053", "species_10614048" ], "products": [ "species_10617006" ], "modifiers": [ [ "species_10616993", "catalyst" ], [ "species_10617028", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q8MXU3", "WBGene00004913", "Q9N415", "WBGene00006513", "Q21049", "WBGene00006364", "P27715", "WBGene00006752", "Q22366", "WBGene00006750", "WBGene00006757", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "WBGene00022271", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "Q21049", "WBGene00006364", "P34693", "WBGene00004921", "O16000", "WBGene00006798", "A5PEW5", "WBGene00004364", "P27715", "WBGene00006752", "G5EEN8", "WBGene00006454", "Q8MXU3", "WBGene00004913", "Q9GUM7", "WBGene00022271", "O02495", "WBGene00004897", "P34815", "WBGene00006757", "Q9GNP0", "WBGene00000295", "Q9N415", "WBGene00006513", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q22366", "WBGene00006750", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "G5EBK2", "WBGene00014084", "Q19136", "WBGene00006306", "species_380873", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "O02495", "WBGene00004897", "Q9GNP0", "WBGene00000295", "P34351", "WBGene00004899", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10615379": { "compartment": "compartment_374932", "id": "reaction_10615379", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10615376", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10654711": { "compartment": "compartment_161320", "id": "reaction_10654711", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10654708", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10657921": { "compartment": "compartment_161320", "id": "reaction_10657921", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10657918", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10657916": { "compartment": "compartment_161320", "id": "reaction_10657916", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10657913", "catalyst" ] ], "additional_components": [ "species_216667", "Q20829", "WBGene00018877" ] }, "reaction_10646383": { "compartment": "compartment_7660", "id": "reaction_10646383", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10646374" ], "products": [ "species_10646380", "species_113541" ], "modifiers": [ [ "species_10646374", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "O44175", "WBGene00004338", "Q09615", "WBGene00014066", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "species_266099", "P34429", "WBGene00018409", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "Q09615", "WBGene00014066", "O44175", "WBGene00004338", "species_266099", "species_109496", "A0A0K3AUS7", "WBGene00021344", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10599229": { "compartment": "compartment_5460", "id": "reaction_10599229", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10599226", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10620180": { "compartment": "compartment_20699", "id": "reaction_10620180", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_29356" ], "products": [ "species_8934421", "species_428248" ], "modifiers": [ [ "species_10620177", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10636098": { "compartment": "compartment_70101", "id": "reaction_10636098", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142811" ], "products": [ "species_2142678", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10604164": { "compartment": "compartment_70101", "id": "reaction_10604164", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10604161", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_109496", "Q93934", "WBGene00011128" ] }, "reaction_10604092": { "compartment": "compartment_5460", "id": "reaction_10604092", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604812": { "compartment": "compartment_70101", "id": "reaction_10604812", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10617876": { "compartment": "compartment_17951", "id": "reaction_10617876", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10617873", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10651381": { "compartment": "compartment_5460", "id": "reaction_10651381", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797920", "species_6797917" ], "modifiers": [ [ "species_10651378", "catalyst" ] ], "additional_components": [ "species_113596", "A0A486WWC6", "WBGene00021355" ] }, "reaction_10665635": { "compartment": "compartment_70101", "id": "reaction_10665635", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10665629" ], "products": [ "species_10665631" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10601956": { "compartment": "compartment_5460", "id": "reaction_10601956", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10601953", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10601613": { "compartment": "compartment_70101", "id": "reaction_10601613", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10601610", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633842": { "compartment": "compartment_70101", "id": "reaction_10633842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861764", "species_29356" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10633839", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10599441": { "compartment": "compartment_70101", "id": "reaction_10599441", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_31311", "species_29356" ], "products": [ "species_70106", "species_73473", "species_31369" ], "modifiers": [ [ "species_10599438", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10602155": { "compartment": "compartment_70101", "id": "reaction_10602155", "reactome": "R-CEL-74215", "name": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_500260", "species_111294" ], "modifiers": [ [ "species_10602152", "catalyst" ] ], "additional_components": [ "species_113599", "species_83956", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_109496" ] }, "reaction_10614847": { "compartment": "compartment_876", "id": "reaction_10614847", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266013", "species_109276" ], "products": [ "species_210382", "species_266074" ], "modifiers": [ [ "species_10614844", "catalyst" ] ], "additional_components": [ "Q9N5V4", "WBGene00022397", "B5BM47", "WBGene00022397", "O18256", "WBGene00022397", "H2L030", "WBGene00022397", "H2L0B7", "WBGene00022397", "A0A486WVP7", "WBGene00022397" ] }, "reaction_10609829": { "compartment": "compartment_5460", "id": "reaction_10609829", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10609826", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10648965": { "compartment": "compartment_12045", "id": "reaction_10648965", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_29768", "species_1498751" ], "modifiers": [ [ "species_10648962", "catalyst" ] ], "additional_components": [ "WBGene00012750" ] }, "reaction_10613738": { "compartment": "compartment_70101", "id": "reaction_10613738", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_209794", "species_71285" ], "modifiers": [ [ "species_10613735", "catalyst" ] ], "additional_components": [ "P34254", "WBGene00015124", "Q20308", "WBGene00018340", "Q22279", "WBGene00011573" ] }, "reaction_10603959": { "compartment": "compartment_5460", "id": "reaction_10603959", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10623581": { "compartment": "compartment_70101", "id": "reaction_10623581", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482627", "species_113592" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10623578", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10602160": { "compartment": "compartment_70101", "id": "reaction_10602160", "reactome": "R-CEL-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10602157", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:57667", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10614546": { "compartment": "compartment_17960", "id": "reaction_10614546", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10614543", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_109496", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10638233": { "compartment": "compartment_5460", "id": "reaction_10638233", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10638230", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10603995": { "compartment": "compartment_5460", "id": "reaction_10603995", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77308" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10643274": { "compartment": "compartment_876", "id": "reaction_10643274", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10643271", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10630841": { "compartment": "compartment_70101", "id": "reaction_10630841", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10664496": { "compartment": "compartment_17963", "id": "reaction_10664496", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10664676": { "compartment": "compartment_17963", "id": "reaction_10664676", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9604808" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10664673", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "O62115", "WBGene00011780", "H2L0F4", "WBGene00044618", "G5ECA6", "WBGene00011780", "O17750", "WBGene00011780", "Q9XU74", "WBGene00011780", "O02310", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62165", "WBGene00011780", "Q20575", "WBGene00009849", "O62375", "WBGene00011780", "G5EDB3", "WBGene00044630", "O62163", "WBGene00011780", "O02231", "WBGene00011780", "O62114", "WBGene00011780", "Q8MQG4", "WBGene00011780" ] }, "reaction_10660515": { "compartment": "compartment_17963", "id": "reaction_10660515", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10660512", "catalyst" ] ], "additional_components": [ "WBGene00000267" ] }, "reaction_10635654": { "compartment": "compartment_70101", "id": "reaction_10635654", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632925" ], "products": [ "species_10632931" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10606792": { "compartment": "compartment_5460", "id": "reaction_10606792", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10606780" ], "products": [ "species_10606782" ], "modifiers": [], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10658283": { "compartment": "compartment_12045", "id": "reaction_10658283", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10658280", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10633575": { "compartment": "compartment_70101", "id": "reaction_10633575", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10620259": { "compartment": "compartment_70101", "id": "reaction_10620259", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10635604": { "compartment": "compartment_12045", "id": "reaction_10635604", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10617418", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10649513": { "compartment": "compartment_12045", "id": "reaction_10649513", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10649510", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10601689": { "compartment": "compartment_70101", "id": "reaction_10601689", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633672": { "compartment": "compartment_70101", "id": "reaction_10633672", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10602203": { "compartment": "compartment_70101", "id": "reaction_10602203", "reactome": "R-CEL-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10604102": { "compartment": "compartment_5460", "id": "reaction_10604102", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_109990", "species_113529" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10604099", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10602864": { "compartment": "compartment_70101", "id": "reaction_10602864", "reactome": "R-CEL-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10601577", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:58069", "CHEBI:58593", "species_727810", "species_109378", "species_109402", "Q20230", "WBGene00009575", "Q20140", "WBGene00009531" ] }, "reaction_10662674": { "compartment": "compartment_70101", "id": "reaction_10662674", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10662671", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10601633": { "compartment": "compartment_70101", "id": "reaction_10601633", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10599656": { "compartment": "compartment_70101", "id": "reaction_10599656", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599579", "species_113592" ], "products": [ "species_29370", "species_10599584" ], "modifiers": [ [ "species_10599653", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "P04630", "WBGene00000285", "P34335", "WBGene00015754", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "G5EEG0", "WBGene00000286", "H2L0I6", "WBGene00022059", "O02159", "WBGene00020378", "Q9N3L4", "WBGene00021753", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10598455": { "compartment": "compartment_70101", "id": "reaction_10598455", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10598452", "catalyst" ] ], "additional_components": [ "Q564Q1", "WBGene00008132", "species_29360" ] }, "reaction_10649967": { "compartment": "compartment_5460", "id": "reaction_10649967", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10648292": { "compartment": "compartment_12045", "id": "reaction_10648292", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10648289", "catalyst" ] ], "additional_components": [ "WBGene00017515" ] }, "reaction_10620296": { "compartment": "compartment_70101", "id": "reaction_10620296", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10620293", "catalyst" ] ], "additional_components": [ "Q10022", "WBGene00020895", "Q19403", "WBGene00008749", "H2KZD1", "WBGene00018756" ] }, "reaction_10617789": { "compartment": "compartment_17951", "id": "reaction_10617789", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633115": { "compartment": "compartment_12045", "id": "reaction_10633115", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10633112", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557", "O45318", "WBGene00022501" ] }, "reaction_10599096": { "compartment": "compartment_5460", "id": "reaction_10599096", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599093", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10633675": { "compartment": "compartment_70101", "id": "reaction_10633675", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10610954": { "compartment": "compartment_70101", "id": "reaction_10610954", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10610951", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10602188": { "compartment": "compartment_70101", "id": "reaction_10602188", "reactome": "R-CEL-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10663917": { "compartment": "compartment_70101", "id": "reaction_10663917", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10663914", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10637076": { "compartment": "compartment_70101", "id": "reaction_10637076", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10632691": { "compartment": "compartment_17957", "id": "reaction_10632691", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_1606280", "species_428256" ], "modifiers": [ [ "species_10632688", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_109496" ] }, "reaction_10650255": { "compartment": "compartment_70101", "id": "reaction_10650255", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10657188": { "compartment": "compartment_876", "id": "reaction_10657188", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10657185", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10636091": { "compartment": "compartment_12045", "id": "reaction_10636091", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10614246", "catalyst" ] ], "additional_components": [ "WBGene00000905" ] }, "reaction_10665955": { "compartment": "compartment_70101", "id": "reaction_10665955", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10665952", "catalyst" ] ], "additional_components": [ "O01927", "WBGene00007549", "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "Q18545", "WBGene00008033" ] }, "reaction_10649446": { "compartment": "compartment_876", "id": "reaction_10649446", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10649443", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649074": { "compartment": "compartment_5460", "id": "reaction_10649074", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10649053" ], "products": [ "species_5693984", "species_10649066", "species_5693978" ], "modifiers": [ [ "species_10649071", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10650376": { "compartment": "compartment_7660", "id": "reaction_10650376", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10650373", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00008458" ] }, "reaction_10599073": { "compartment": "compartment_70101", "id": "reaction_10599073", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10599070", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10604569": { "compartment": "compartment_70101", "id": "reaction_10604569", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10604566", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10665633": { "compartment": "compartment_70101", "id": "reaction_10665633", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665631" ], "products": [ "species_189386", "species_10665629" ], "modifiers": [], "additional_components": [ "O01814", "WBGene00002257", "species_9661418", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O01812", "WBGene00002258", "O45010", "WBGene00021127", "O02324", "WBGene00002260", "Q965W1", "WBGene00021486" ] }, "reaction_10614855": { "compartment": "compartment_876", "id": "reaction_10614855", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10614852", "catalyst" ] ], "additional_components": [ "WBGene00003413" ] }, "reaction_10632904": { "compartment": "compartment_20699", "id": "reaction_10632904", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_744227" ], "products": [ "species_205687", "species_1660674" ], "modifiers": [ [ "species_10632901", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10658932": { "compartment": "compartment_7660", "id": "reaction_10658932", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10658929", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_216667", "Q09374", "WBGene00022673" ] }, "reaction_10648973": { "compartment": "compartment_13977", "id": "reaction_10648973", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693747", "species_5693752" ], "products": [ "species_5693733", "species_5693736" ], "modifiers": [ [ "species_10648970", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10598743": { "compartment": "compartment_70101", "id": "reaction_10598743", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_29406" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10625839": { "compartment": "compartment_876", "id": "reaction_10625839", "reactome": "R-CEL-917892", "name": "FLVCR1-1 transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71185" ], "products": [ "species_917877" ], "modifiers": [ [ "species_10625836", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10633276": { "compartment": "compartment_12045", "id": "reaction_10633276", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10633273", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10620499": { "compartment": "compartment_70101", "id": "reaction_10620499", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates CERT1-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620471", "species_113592" ], "products": [ "species_29370", "species_10620474" ], "modifiers": [ [ "species_10620496", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "O45818", "WBGene00012019", "Q9XUJ7", "WBGene00012352" ] }, "reaction_10625298": { "compartment": "compartment_5460", "id": "reaction_10625298", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_113557", "species_159549" ], "modifiers": [ [ "species_10625295", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10646515": { "compartment": "compartment_5668575", "id": "reaction_10646515", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10602200": { "compartment": "compartment_70101", "id": "reaction_10602200", "reactome": "R-CEL-74249", "name": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500245", "species_29372" ], "products": [ "species_500244", "species_83956" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "species_112016", "CHEBI:58576", "U4PSA1", "WBGene00019298" ] }, "reaction_10598754": { "compartment": "compartment_5460", "id": "reaction_10598754", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10656850": { "compartment": "compartment_70101", "id": "reaction_10656850", "reactome": "R-CEL-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10613758": { "compartment": "compartment_70101", "id": "reaction_10613758", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_159362", "species_113528" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10649405": { "compartment": "compartment_5460", "id": "reaction_10649405", "reactome": "R-CEL-5695980", "name": "ACAD10 dehydrogenates S-2MPDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695946", "species_113596" ], "products": [ "species_5695949", "species_31649" ], "modifiers": [ [ "species_10649402", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10648981": { "compartment": "compartment_12045", "id": "reaction_10648981", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10648978", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10603973": { "compartment": "compartment_5460", "id": "reaction_10603973", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10620208": { "compartment": "compartment_70101", "id": "reaction_10620208", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10637073": { "compartment": "compartment_70101", "id": "reaction_10637073", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10615384": { "compartment": "compartment_5460", "id": "reaction_10615384", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10615381", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10598437": { "compartment": "compartment_70101", "id": "reaction_10598437", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_109496" ] }, "reaction_10602986": { "compartment": "compartment_17951", "id": "reaction_10602986", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390404", "species_390426" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10601687": { "compartment": "compartment_70101", "id": "reaction_10601687", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10601630", "catalyst" ] ], "additional_components": [ "species_216667", "Q18677", "WBGene00000964" ] }, "reaction_10613721": { "compartment": "compartment_1462052", "id": "reaction_10613721", "reactome": "R-CEL-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351603", "species_351597", "species_351599" ], "modifiers": [ [ "species_10613718", "catalyst" ] ], "additional_components": [ "Q9XTQ6", "WBGene00006541", "CHEBI:18315", "CHEBI:28694" ] }, "reaction_10598445": { "compartment": "compartment_70101", "id": "reaction_10598445", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_30170" ], "products": [ "species_29548", "species_29452" ], "modifiers": [ [ "species_10598442", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10599677": { "compartment": "compartment_70101", "id": "reaction_10599677", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599664" ], "products": [ "species_10599669" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10632966": { "compartment": "compartment_20699", "id": "reaction_10632966", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632960" ], "products": [ "species_10632925" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10656397": { "compartment": "compartment_171062", "id": "reaction_10656397", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10656388", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10646163": { "compartment": "compartment_17963", "id": "reaction_10646163", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10646160", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00043980" ] }, "reaction_10613668": { "compartment": "compartment_984", "id": "reaction_10613668", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10598667": { "compartment": "compartment_5460", "id": "reaction_10598667", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113557", "species_113593" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10598664", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_199207", "species_266099" ] }, "reaction_10603955": { "compartment": "compartment_5460", "id": "reaction_10603955", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10648947": { "compartment": "compartment_17957", "id": "reaction_10648947", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10648944", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10636081": { "compartment": "compartment_12045", "id": "reaction_10636081", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10636078", "catalyst" ] ], "additional_components": [ "O44706", "WBGene00016697", "O44655", "WBGene00015040", "O44704", "WBGene00016686", "O44658", "WBGene00015043", "Q9N4Q4", "WBGene00021168", "O44657", "WBGene00015042", "Q27482", "WBGene00016768", "O02628", "WBGene00015400", "O16362", "WBGene00018413", "O61935", "WBGene00020386", "O45364", "WBGene00008829", "O16670", "WBGene00018262", "O44649", "WBGene00019473", "G5EE22", "WBGene00012448", "Q27465", "WBGene00015135", "O62378", "WBGene00011698", "O61204", "WBGene00015045", "Q20315", "WBGene00018333", "Q965T7", "WBGene00021710", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "Q27471", "WBGene00016092", "Q27470", "WBGene00015709", "O16673", "WBGene00018260", "Q9N5I1", "WBGene00019565", "O44656", "WBGene00015041", "O45659", "WBGene00010589", "O44650", "WBGene00019472", "Q27499", "WBGene00018334", "G5ECD0", "WBGene00007362", "O16220", "WBGene00016786", "O02627", "WBGene00015399", "O44651", "WBGene00019471", "O16671", "WBGene00018261", "O02641", "WBGene00019967", "H2KYS3", "WBGene00000905", "O62377", "WBGene00011699", "O16482", "WBGene00016860", "A0A0M7RF98", "WBGene00018264", "H2KY69", "WBGene00015044" ] }, "reaction_10620190": { "compartment": "compartment_70101", "id": "reaction_10620190", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428198", "species_428193" ], "modifiers": [ [ "species_10620187", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10598847": { "compartment": "compartment_5460", "id": "reaction_10598847", "reactome": "R-CEL-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10598844", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10631244": { "compartment": "compartment_70101", "id": "reaction_10631244", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10631239", "catalyst" ] ], "additional_components": [ "species_216667", "Q94288", "WBGene00000287", "Q18136", "WBGene00006861", "species_74016", "species_71185", "Q17941", "WBGene00000102", "species_113596", "P04630", "WBGene00000285", "Q09980", "WBGene00017394", "Q18688", "WBGene00000915", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q9XTG7", "WBGene00000103", "G5EEG0", "WBGene00000286", "species_73524", "O02159", "WBGene00020378", "species_1497857", "species_29870", "O16305", "WBGene00000552", "G5EDZ8", "WBGene00000288" ] }, "reaction_10601643": { "compartment": "compartment_70101", "id": "reaction_10601643", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10601640", "catalyst" ] ], "additional_components": [ "species_216667", "Q19437", "WBGene00017440" ] }, "reaction_10633758": { "compartment": "compartment_70101", "id": "reaction_10633758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10662836": { "compartment": "compartment_70101", "id": "reaction_10662836", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10662833", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10633620": { "compartment": "compartment_70101", "id": "reaction_10633620", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10633617", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10603977": { "compartment": "compartment_5460", "id": "reaction_10603977", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10657668": { "compartment": "compartment_984", "id": "reaction_10657668", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936165", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851369" ], "modifiers": [ [ "species_10657665", "catalyst" ] ], "additional_components": [ "species_29420", "species_29370", "CHEBI:58069", "species_205687", "species_727810", "species_76577", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10599797": { "compartment": "compartment_70101", "id": "reaction_10599797", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10599794", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10623690": { "compartment": "compartment_5460", "id": "reaction_10623690", "reactome": "R-CEL-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10623685", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_205687", "CHEBI:58069", "CHEBI:58593", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10617879": { "compartment": "compartment_17951", "id": "reaction_10617879", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390419", "species_390440" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10602983", "catalyst" ] ], "additional_components": [ "O45218", "WBGene00000081", "G5EFP8", "WBGene00012911", "species_113596" ] }, "reaction_10660679": { "compartment": "compartment_984", "id": "reaction_10660679", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10660676", "catalyst" ] ], "additional_components": [ "O01811", "WBGene00003170", "species_74016", "Q966L1", "WBGene00017089", "Q2V071", "WBGene00044697", "B1V898", "WBGene00077701", "Q21427", "WBGene00010775" ] }, "reaction_10646108": { "compartment": "compartment_70101", "id": "reaction_10646108", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_5652213" ], "products": [ "species_70106", "species_73473", "species_29532" ], "modifiers": [ [ "species_10646105", "catalyst" ] ], "additional_components": [ "species_216667", "Q21702", "WBGene00011003" ] }, "reaction_10622852": { "compartment": "compartment_70101", "id": "reaction_10622852", "reactome": "R-CEL-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622850" ], "products": [ "species_10599579", "species_76577" ], "modifiers": [], "additional_components": [ "species_76577", "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696" ] }, "reaction_10659921": { "compartment": "compartment_5460", "id": "reaction_10659921", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524038", "species_113559" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10659918", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10606630": { "compartment": "compartment_7660", "id": "reaction_10606630", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602999" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00011543", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10632627": { "compartment": "compartment_161320", "id": "reaction_10632627", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10632624", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10650017": { "compartment": "compartment_70101", "id": "reaction_10650017", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784964", "species_29356" ], "products": [ "species_561052", "species_29702" ], "modifiers": [ [ "species_10650014", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10632606": { "compartment": "compartment_161320", "id": "reaction_10632606", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10632603", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10604965": { "compartment": "compartment_70101", "id": "reaction_10604965", "reactome": "R-CEL-112033", "name": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_500172", "species_29372" ], "modifiers": [ [ "species_10602175", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:28997", "species_83927", "U4PSA1", "WBGene00019298" ] }, "reaction_10630856": { "compartment": "compartment_5460", "id": "reaction_10630856", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29376", "species_113521" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620269": { "compartment": "compartment_984", "id": "reaction_10620269", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10620266", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10599499": { "compartment": "compartment_70101", "id": "reaction_10599499", "reactome": "R-CEL-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10599496", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10660470": { "compartment": "compartment_5668575", "id": "reaction_10660470", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10660467", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10623783": { "compartment": "compartment_5460", "id": "reaction_10623783", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_113552", "species_113529", "species_113593" ], "products": [ "species_31339", "species_113548", "species_113563", "species_113581" ], "modifiers": [ [ "species_10623780", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10633623": { "compartment": "compartment_70101", "id": "reaction_10633623", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10603991": { "compartment": "compartment_5460", "id": "reaction_10603991", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10633658": { "compartment": "compartment_70101", "id": "reaction_10633658", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629746", "species_29356" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10633578": { "compartment": "compartment_70101", "id": "reaction_10633578", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023943", "species_29356" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10633566", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10598621": { "compartment": "compartment_70101", "id": "reaction_10598621", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10598618", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "G5EBJ7", "WBGene00001404", "species_109496" ] }, "reaction_10635652": { "compartment": "compartment_7660", "id": "reaction_10635652", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632943", "species_10635648" ], "products": [ "species_10632941", "species_10635650" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10620130": { "compartment": "compartment_70101", "id": "reaction_10620130", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10620127", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10602133": { "compartment": "compartment_5460", "id": "reaction_10602133", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10602130", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10604815": { "compartment": "compartment_70101", "id": "reaction_10604815", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10604793" ], "products": [ "species_10604790", "species_111745" ], "modifiers": [ [ "species_10604793", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10598741": { "compartment": "compartment_5460", "id": "reaction_10598741", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "Q23621", "WBGene00014095" ] }, "reaction_10633764": { "compartment": "compartment_70101", "id": "reaction_10633764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10635606": { "compartment": "compartment_17957", "id": "reaction_10635606", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10623873", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10651363": { "compartment": "compartment_70101", "id": "reaction_10651363", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29642", "species_29356" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10651360", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10664533": { "compartment": "compartment_17963", "id": "reaction_10664533", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10601948": { "compartment": "compartment_5460", "id": "reaction_10601948", "reactome": "R-CEL-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10598998", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10601673": { "compartment": "compartment_70101", "id": "reaction_10601673", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109382", "species_111355" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10601670", "catalyst" ] ], "additional_components": [ "Q9N588", "WBGene00022455", "species_109496" ] }, "reaction_10599471": { "compartment": "compartment_70101", "id": "reaction_10599471", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10599468", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10649413": { "compartment": "compartment_5460", "id": "reaction_10649413", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5690531", "species_113593" ], "products": [ "species_159448", "species_5690542", "species_159450" ], "modifiers": [ [ "species_10649410", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10633309": { "compartment": "compartment_171062", "id": "reaction_10633309", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806238", "species_29356" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10633306", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10602123": { "compartment": "compartment_5460", "id": "reaction_10602123", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10602120", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10615281": { "compartment": "compartment_5460", "id": "reaction_10615281", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10615278", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10604557": { "compartment": "compartment_70101", "id": "reaction_10604557", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "species_727810", "species_76577", "species_109378", "species_109386", "Q09629", "WBGene00014058" ] }, "reaction_10637079": { "compartment": "compartment_70101", "id": "reaction_10637079", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10637070", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10666203": { "compartment": "compartment_70101", "id": "reaction_10666203", "reactome": "R-CEL-9731661", "name": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_9731609" ], "products": [ "species_9731659", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10632609": { "compartment": "compartment_161320", "id": "reaction_10632609", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632564", "species_1605610" ], "products": [ "species_10632566" ], "modifiers": [ [ "species_10632564", "catalyst" ] ], "additional_components": [ "WBGene00021095", "O02106", "WBGene00021095", "species_1605610", "WBGene00021095" ] }, "reaction_10633583": { "compartment": "compartment_70101", "id": "reaction_10633583", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633580", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5EGN9", "WBGene00012016", "G5ECL2", "WBGene00006763", "P34370", "WBGene00086546" ] }, "reaction_10649455": { "compartment": "compartment_5460", "id": "reaction_10649455", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10649452", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10648824": { "compartment": "compartment_12045", "id": "reaction_10648824", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10648821", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10656394": { "compartment": "compartment_70101", "id": "reaction_10656394", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656386" ], "products": [ "species_10656392" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00021683", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10603953": { "compartment": "compartment_5460", "id": "reaction_10603953", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10603950", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10660930": { "compartment": "compartment_70101", "id": "reaction_10660930", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10660927", "catalyst" ] ], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477" ] }, "reaction_10598766": { "compartment": "compartment_5460", "id": "reaction_10598766", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10598738", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10630854": { "compartment": "compartment_5460", "id": "reaction_10630854", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_29376", "species_113521" ], "modifiers": [ [ "species_10630851", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10649384": { "compartment": "compartment_70101", "id": "reaction_10649384", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29666" ], "products": [ "species_191293", "species_111294", "species_76577" ], "modifiers": [ [ "species_10649381", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10664694": { "compartment": "compartment_17963", "id": "reaction_10664694", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10598427": { "compartment": "compartment_70101", "id": "reaction_10598427", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10598424", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10635656": { "compartment": "compartment_70101", "id": "reaction_10635656", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632931", "species_10614210" ], "products": [ "species_10632933" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10657379": { "compartment": "compartment_12045", "id": "reaction_10657379", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598731": { "compartment": "compartment_70101", "id": "reaction_10598731", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76213", "species_29404" ], "products": [ "species_29448", "species_29406" ], "modifiers": [ [ "species_10598728", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10610944": { "compartment": "compartment_70101", "id": "reaction_10610944", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10646517": { "compartment": "compartment_5668572", "id": "reaction_10646517", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10614529": { "compartment": "compartment_17960", "id": "reaction_10614529", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10614526", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10665612": { "compartment": "compartment_70101", "id": "reaction_10665612", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610517", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10655768": { "compartment": "compartment_70101", "id": "reaction_10655768", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10655765", "catalyst" ] ], "additional_components": [ "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10601685": { "compartment": "compartment_70101", "id": "reaction_10601685", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10613756": { "compartment": "compartment_984", "id": "reaction_10613756", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10599279": { "compartment": "compartment_5460", "id": "reaction_10599279", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10599276", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10632693": { "compartment": "compartment_161320", "id": "reaction_10632693", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10649944": { "compartment": "compartment_5460", "id": "reaction_10649944", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10649941", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10623815": { "compartment": "compartment_70101", "id": "reaction_10623815", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_113578" ], "products": [ "species_29602", "species_29366", "species_31633" ], "modifiers": [ [ "species_10623812", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10646519": { "compartment": "compartment_5668572", "id": "reaction_10646519", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10646512", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "P34269", "WBGene00015332", "species_936901" ] }, "reaction_10630837": { "compartment": "compartment_70101", "id": "reaction_10630837", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_113528", "species_29356" ], "modifiers": [ [ "species_10630834", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10620211": { "compartment": "compartment_70101", "id": "reaction_10620211", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10656412": { "compartment": "compartment_70101", "id": "reaction_10656412", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10633755": { "compartment": "compartment_876", "id": "reaction_10633755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10633752", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "Q17848", "WBGene00002146" ] }, "reaction_10647415": { "compartment": "compartment_70101", "id": "reaction_10647415", "reactome": "R-CEL-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10630656", "catalyst" ] ], "additional_components": [ "CHEBI:16427", "CHEBI:18392", "CHEBI:16427", "CHEBI:18392", "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q9XW61", "WBGene00003414", "Q19048", "WBGene00003409" ] }, "reaction_10605609": { "compartment": "compartment_17957", "id": "reaction_10605609", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10605606", "catalyst" ] ], "additional_components": [ "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "G5ED43", "WBGene00001480", "G5ECJ8", "WBGene00001478", "species_113596", "G5EBJ9", "WBGene00001477" ] }, "reaction_10636567": { "compartment": "compartment_5460", "id": "reaction_10636567", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636563", "species_10630212" ], "products": [ "species_10636565", "species_10630208", "species_113529" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_31649", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9U1X0", "WBGene00013376", "species_113596", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10666187": { "compartment": "compartment_70101", "id": "reaction_10666187", "reactome": "R-CEL-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10614764": { "compartment": "compartment_876", "id": "reaction_10614764", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10614761", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10601653": { "compartment": "compartment_70101", "id": "reaction_10601653", "reactome": "R-CEL-73596", "name": "dCMP + H2O => dUMP + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_109378", "species_29356" ], "products": [ "species_109382", "species_31633" ], "modifiers": [ [ "species_10601650", "catalyst" ] ], "additional_components": [ "P30648", "WBGene00014034" ] }, "reaction_10615392": { "compartment": "compartment_70101", "id": "reaction_10615392", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10615389", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10647362": { "compartment": "compartment_70101", "id": "reaction_10647362", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10647359", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10633327": { "compartment": "compartment_171062", "id": "reaction_10633327", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10633169", "catalyst" ] ], "additional_components": [ "species_74016", "species_109496", "G5EDY0", "WBGene00009552" ] }, "reaction_10620557": { "compartment": "compartment_20699", "id": "reaction_10620557", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10620554", "catalyst" ] ], "additional_components": [ "WBGene00004894" ] }, "reaction_10606787": { "compartment": "compartment_5460", "id": "reaction_10606787", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606782" ], "products": [ "species_113521", "species_10606784" ], "modifiers": [ [ "species_10606782", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "species_29370", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "species_29372", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10662486": { "compartment": "compartment_5460", "id": "reaction_10662486", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10662483", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10606790": { "compartment": "compartment_5460", "id": "reaction_10606790", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606784", "species_163953" ], "products": [ "species_10606780", "species_113529", "species_113593" ], "modifiers": [ [ "species_10606784", "catalyst" ] ], "additional_components": [ "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207", "O16298", "WBGene00017982", "Q18803", "WBGene00000210", "O16314", "WBGene00015460", "Q95XJ0", "WBGene00022089", "P46561", "WBGene00000229", "O16517", "WBGene00020275", "Q09544", "WBGene00019061", "Q7JNG1", "WBGene00000230", "Q9BKS0", "WBGene00022336", "Q9XXK1", "WBGene00010419", "Q22021", "WBGene00011273", "Q17763", "WBGene00007385", "species_113592", "Q21732", "WBGene00011015", "Q19126", "WBGene00000207" ] }, "reaction_10599491": { "compartment": "compartment_70101", "id": "reaction_10599491", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10620185": { "compartment": "compartment_70101", "id": "reaction_10620185", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10617912", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10651159": { "compartment": "compartment_5460", "id": "reaction_10651159", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10651143", "species_10649049" ], "products": [ "species_10649051", "species_10651151" ], "modifiers": [ [ "species_10651156", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00009918", "WBGene00009918", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "CHEBI:17460", "P52899", "WBGene00011510", "Q19749", "WBGene00009082", "O44451", "WBGene00015413", "species_113596", "Q23629", "WBGene00014098", "WBGene00001590" ] }, "reaction_10620261": { "compartment": "compartment_70101", "id": "reaction_10620261", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10620256", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10656406": { "compartment": "compartment_70101", "id": "reaction_10656406", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633087", "species_10656402" ], "products": [ "species_10656404" ], "modifiers": [], "additional_components": [ "WBGene00003475", "WBGene00003477", "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10662852": { "compartment": "compartment_70101", "id": "reaction_10662852", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10662849", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10657682": { "compartment": "compartment_528865", "id": "reaction_10657682", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851509", "species_8851517" ], "products": [ "species_8851518", "species_8851513", "species_5228597" ], "modifiers": [ [ "species_10657679", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_29470", "species_29420", "species_205687", "CHEBI:58069", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10630215": { "compartment": "compartment_5460", "id": "reaction_10630215", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630201", "species_379721", "species_10630208" ], "products": [ "species_379697", "species_10630210", "species_10630212" ], "modifiers": [ [ "species_10630201", "catalyst" ], [ "species_10630208", "catalyst" ] ], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "CHEBI:33739", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33737", "Q9NA32", "WBGene00013532", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "Q9NA32", "WBGene00013532", "CHEBI:33738" ] }, "reaction_10662828": { "compartment": "compartment_12045", "id": "reaction_10662828", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10662825", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10657539": { "compartment": "compartment_70101", "id": "reaction_10657539", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10657536", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_5334668", "species_6810408", "species_1806200", "WBGene00012353" ] }, "reaction_10651392": { "compartment": "compartment_5460", "id": "reaction_10651392", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10651389", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10633516": { "compartment": "compartment_70101", "id": "reaction_10633516", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10633513", "catalyst" ] ], "additional_components": [ "Q19420", "WBGene00008765", "species_109496" ] }, "reaction_10657655": { "compartment": "compartment_17963", "id": "reaction_10657655", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851227", "species_425969", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "species_109366", "species_727810", "species_109402", "species_113578", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10599431": { "compartment": "compartment_70101", "id": "reaction_10599431", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_29424", "species_31311" ], "modifiers": [ [ "species_10599428", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10615273": { "compartment": "compartment_70101", "id": "reaction_10615273", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372364", "species_76190" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10602899", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10601717": { "compartment": "compartment_70101", "id": "reaction_10601717", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10601714", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10599461": { "compartment": "compartment_70101", "id": "reaction_10599461", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10599458", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10633638": { "compartment": "compartment_70101", "id": "reaction_10633638", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10598867": { "compartment": "compartment_5460", "id": "reaction_10598867", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10598864", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10604743": { "compartment": "compartment_70101", "id": "reaction_10604743", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10601610", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10633655": { "compartment": "compartment_70101", "id": "reaction_10633655", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10599055": { "compartment": "compartment_70101", "id": "reaction_10599055", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10599052", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10612334": { "compartment": "compartment_70101", "id": "reaction_10612334", "reactome": "R-CEL-203565", "name": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612323", "species_10612328" ], "products": [ "species_10612332" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "WBGene00007840", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10657382": { "compartment": "compartment_12045", "id": "reaction_10657382", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10649523", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q9N4S3", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10598828": { "compartment": "compartment_5460", "id": "reaction_10598828", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10598751", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10620205": { "compartment": "compartment_70101", "id": "reaction_10620205", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10620202", "catalyst" ] ], "additional_components": [ "species_29364", "species_73473", "species_29366", "species_29360", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10635608": { "compartment": "compartment_12045", "id": "reaction_10635608", "reactome": "R-CEL-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10635594", "catalyst" ] ], "additional_components": [ "V6CLI5", "WBGene00022037", "species_109496" ] }, "reaction_10611410": { "compartment": "compartment_876", "id": "reaction_10611410", "reactome": "R-CEL-200396", "name": "Creatine transport across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_200381" ], "products": [ "species_83910", "species_29916" ], "modifiers": [ [ "species_10611407", "catalyst" ] ], "additional_components": [ "P90890", "WBGene00004901", "H2KYM8", "WBGene00018980", "G5EBN9", "WBGene00004902", "O01843", "WBGene00018980", "Q9XUG5", "WBGene00004908", "O45915", "WBGene00004909", "G5EBM5", "WBGene00004904", "G5EF43", "WBGene00004910", "G5EE39", "WBGene00004906" ] }, "reaction_10632713": { "compartment": "compartment_161320", "id": "reaction_10632713", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10632710", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10632580": { "compartment": "compartment_161320", "id": "reaction_10632580", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632566", "species_1605715" ], "products": [ "species_10632564", "species_1605641", "species_1605658" ], "modifiers": [ [ "species_10632577", "catalyst" ] ], "additional_components": [ "O02106", "WBGene00021095", "species_1605610", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10660506": { "compartment": "compartment_5460", "id": "reaction_10660506", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660497", "species_10660485" ], "products": [ "species_10660499", "species_10660483" ], "modifiers": [ [ "species_10660504", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "Q9XTU9", "WBGene00013029", "CHEBI:33739", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:49883", "WBGene00013029", "WBGene00001033" ] }, "reaction_10650398": { "compartment": "compartment_70101", "id": "reaction_10650398", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10650395", "catalyst" ] ], "additional_components": [ "species_109496", "O01926", "WBGene00007548" ] }, "reaction_10633649": { "compartment": "compartment_70101", "id": "reaction_10633649", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10656419": { "compartment": "compartment_17951", "id": "reaction_10656419", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10656416", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10657299": { "compartment": "compartment_17957", "id": "reaction_10657299", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657295", "species_8848288" ], "products": [ "species_10657297" ], "modifiers": [], "additional_components": [ "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457", "species_164991", "species_5690542", "species_164991", "species_5690542", "Q45EL0", "WBGene00044603", "Q09603", "WBGene00001153", "Q9XXJ2", "WBGene00012457" ] }, "reaction_10603989": { "compartment": "compartment_5460", "id": "reaction_10603989", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10602994": { "compartment": "compartment_70101", "id": "reaction_10602994", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_75973" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10602991", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10657658": { "compartment": "compartment_17963", "id": "reaction_10657658", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851233", "species_2022884" ], "products": [ "species_425969", "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10657652", "catalyst" ] ], "additional_components": [ "species_29494", "species_30187", "species_29438", "species_29470", "species_29420", "CHEBI:58369", "CHEBI:58069", "species_205687", "Q18411", "WBGene00016380", "species_74016", "Q21815", "WBGene00003254" ] }, "reaction_10616356": { "compartment": "compartment_70101", "id": "reaction_10616356", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10610941", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10599690": { "compartment": "compartment_70101", "id": "reaction_10599690", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599669" ], "products": [ "species_70113", "species_10599687" ], "modifiers": [ [ "species_10599674", "catalyst" ] ], "additional_components": [ "species_266099", "H2KYQ5", "WBGene00006863", "species_266099", "H2KYQ5", "WBGene00006863", "WBGene00011050" ] }, "reaction_10650252": { "compartment": "compartment_70101", "id": "reaction_10650252", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10650249", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10646508": { "compartment": "compartment_5668572", "id": "reaction_10646508", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10646505", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "species_216667", "Q9XUS8", "WBGene00010661", "Q95XC6", "WBGene00022231", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "O76708", "WBGene00021553" ] }, "reaction_10598380": { "compartment": "compartment_70101", "id": "reaction_10598380", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10598377", "catalyst" ] ], "additional_components": [ "O44906", "WBGene00021043", "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232" ] }, "reaction_10665624": { "compartment": "compartment_876", "id": "reaction_10665624", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10665621", "catalyst" ] ], "additional_components": [ "WBGene00018566" ] }, "reaction_10632701": { "compartment": "compartment_161320", "id": "reaction_10632701", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606573", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632698", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10649955": { "compartment": "compartment_70101", "id": "reaction_10649955", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10649952", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10662666": { "compartment": "compartment_5460", "id": "reaction_10662666", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10649957", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10648449": { "compartment": "compartment_5460", "id": "reaction_10648449", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10648446", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "O01862", "WBGene00020989", "Q94245", "WBGene00019015", "Q9GYN3", "WBGene00020989" ] }, "reaction_10632945": { "compartment": "compartment_70101", "id": "reaction_10632945", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10632933" ], "products": [ "species_10632943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10648429": { "compartment": "compartment_70101", "id": "reaction_10648429", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10648426", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O45003", "WBGene00020989", "P34419", "WBGene00018370", "O01862", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10666184": { "compartment": "compartment_70101", "id": "reaction_10666184", "reactome": "R-CEL-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10602185", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10613760": { "compartment": "compartment_984", "id": "reaction_10613760", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10657333": { "compartment": "compartment_70101", "id": "reaction_10657333", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10657329" ], "products": [ "species_10657331" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10649964": { "compartment": "compartment_5460", "id": "reaction_10649964", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10649961", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10636076": { "compartment": "compartment_70101", "id": "reaction_10636076", "reactome": "R-CEL-2161791", "name": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142718" ], "products": [ "species_29356", "species_111745", "species_2142707" ], "modifiers": [ [ "species_10636073", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10620511": { "compartment": "compartment_70101", "id": "reaction_10620511", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10620474" ], "products": [ "species_29370", "species_10620503" ], "modifiers": [ [ "species_10620508", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10648998": { "compartment": "compartment_876", "id": "reaction_10648998", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10648995", "catalyst" ] ], "additional_components": [ "Q93332", "WBGene00007954", "P91406", "WBGene00020082" ] }, "reaction_10664531": { "compartment": "compartment_17963", "id": "reaction_10664531", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10664528", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10602219": { "compartment": "compartment_70101", "id": "reaction_10602219", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10602214", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q23588", "WBGene00022817" ] }, "reaction_10664696": { "compartment": "compartment_17963", "id": "reaction_10664696", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10649040", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10655995": { "compartment": "compartment_13977", "id": "reaction_10655995", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10655992", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10649930": { "compartment": "compartment_17951", "id": "reaction_10649930", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10649927", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10606628": { "compartment": "compartment_7660", "id": "reaction_10606628", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10606626" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10633652": { "compartment": "compartment_70101", "id": "reaction_10633652", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10623695": { "compartment": "compartment_876", "id": "reaction_10623695", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10623692", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10646096": { "compartment": "compartment_70101", "id": "reaction_10646096", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10610732", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q9U2J5", "WBGene00016985", "Q9NAI5", "WBGene00016985", "Q23320", "WBGene00016985", "Q22352", "WBGene00020369" ] }, "reaction_10636042": { "compartment": "compartment_70101", "id": "reaction_10636042", "reactome": "R-CEL-2161187", "name": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9731626", "species_29356" ], "products": [ "species_29602", "species_9731652" ], "modifiers": [ [ "species_10636039", "catalyst" ] ], "additional_components": [ "species_216667", "Q8IG39", "WBGene00016632" ] }, "reaction_10650368": { "compartment": "compartment_5460", "id": "reaction_10650368", "reactome": "R-CEL-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10650365", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "WBGene00014058" ] }, "reaction_10654704": { "compartment": "compartment_70101", "id": "reaction_10654704", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6799497" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10654701", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10604818": { "compartment": "compartment_70101", "id": "reaction_10604818", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604809", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10665619": { "compartment": "compartment_70101", "id": "reaction_10665619", "reactome": "R-CEL-9661408", "name": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444" ], "products": [ "species_71185" ], "modifiers": [ [ "species_10665616", "catalyst" ] ], "additional_components": [ "WBGene00015632" ] }, "reaction_10630839": { "compartment": "compartment_876", "id": "reaction_10630839", "reactome": "R-CEL-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10648813": { "compartment": "compartment_70101", "id": "reaction_10648813", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10648810", "catalyst" ] ], "additional_components": [ "species_216667", "Q17335", "WBGene00019240" ] }, "reaction_10633718": { "compartment": "compartment_70101", "id": "reaction_10633718", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10633635", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10651186": { "compartment": "compartment_5460", "id": "reaction_10651186", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_10651176", "species_2162265" ], "products": [ "species_6793613", "species_379705", "species_10649049" ], "modifiers": [ [ "species_10651183", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10633187": { "compartment": "compartment_171062", "id": "reaction_10633187", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10633184", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "species_74016", "Q9TXI7", "WBGene00006932", "species_109496", "species_266099", "G5EDY0", "WBGene00009552" ] }, "reaction_10664715": { "compartment": "compartment_17963", "id": "reaction_10664715", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10664712", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163", "G5EE06", "WBGene00043986", "G5EEE1", "WBGene00020222", "G5EDR5", "WBGene00001505", "G5EFP5", "WBGene00006402", "G5EEL7", "WBGene00001507" ] }, "reaction_10603993": { "compartment": "compartment_5460", "id": "reaction_10603993", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10599018", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10649064": { "compartment": "compartment_5460", "id": "reaction_10649064", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10649049" ], "products": [ "species_29376", "species_10649053" ], "modifiers": [ [ "species_10649061", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10599420": { "compartment": "compartment_5460", "id": "reaction_10599420", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_35139", "species_113533" ], "products": [ "species_29376", "species_113536", "species_113546" ], "modifiers": [ [ "species_10599417", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_113531", "species_198836" ] }, "reaction_10599822": { "compartment": "compartment_70101", "id": "reaction_10599822", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10599819", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10599453": { "compartment": "compartment_70101", "id": "reaction_10599453", "reactome": "R-CEL-71261", "name": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31369", "species_29368", "species_29406" ], "products": [ "species_113528", "species_30235", "species_29434" ], "modifiers": [ [ "species_10599450", "catalyst" ] ], "additional_components": [ "Q19000", "WBGene00001522", "species_113531", "species_198836" ] }, "reaction_10599771": { "compartment": "compartment_70101", "id": "reaction_10599771", "reactome": "R-CEL-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10599768", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10617719": { "compartment": "compartment_17951", "id": "reaction_10617719", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10617716", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10604547": { "compartment": "compartment_70101", "id": "reaction_10604547", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500077", "species_29370" ], "products": [ "species_500071", "species_113592" ], "modifiers": [ [ "species_10601866", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58595", "CHEBI:57673", "species_113578", "WBGene00020190" ] }, "reaction_10632681": { "compartment": "compartment_876", "id": "reaction_10632681", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632678", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_109496" ] }, "reaction_10632559": { "compartment": "compartment_17938", "id": "reaction_10632559", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605592", "species_1605715" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10632556", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "G5ECR8", "WBGene00008706" ] }, "reaction_10606619": { "compartment": "compartment_7660", "id": "reaction_10606619", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10602960" ], "modifiers": [ [ "species_10606617", "catalyst" ] ], "additional_components": [ "WBGene00009342", "Q9TZ70", "WBGene00003510", "P41846", "WBGene00003378" ] }, "reaction_10612354": { "compartment": "compartment_24337", "id": "reaction_10612354", "reactome": "R-CEL-203625", "name": "NOSTRIN mediated translocation of eNOS from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612332" ], "products": [ "species_10612352" ], "modifiers": [], "additional_components": [ "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "Q94051", "WBGene00000301", "species_113596", "species_216667", "P39055", "WBGene00001130", "Q8I4M6", "WBGene00007840", "species_73524", "species_71185", "Q6A573", "WBGene00021549", "species_29870", "Q94051", "WBGene00000301", "species_113596" ] }, "reaction_10606598": { "compartment": "compartment_7660", "id": "reaction_10606598", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10606592" ], "products": [ "species_10606596" ], "modifiers": [], "additional_components": [ "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928", "A0A1T5HUK9", "WBGene00013732", "Q9XUY2", "WBGene00010115", "species_76577", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142", "Q9NAH7", "WBGene00012928" ] }, "reaction_10599269": { "compartment": "compartment_5460", "id": "reaction_10599269", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10599266", "catalyst" ] ], "additional_components": [ "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "CHEBI:17460", "species_113596" ] }, "reaction_10610962": { "compartment": "compartment_70101", "id": "reaction_10610962", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10610959", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10634928": { "compartment": "compartment_70101", "id": "reaction_10634928", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_2023974", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62924", "species_1629732", "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10617792": { "compartment": "compartment_17951", "id": "reaction_10617792", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10617786", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10633285": { "compartment": "compartment_171062", "id": "reaction_10633285", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10599247": { "compartment": "compartment_5460", "id": "reaction_10599247", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10599244", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864" ] }, "reaction_10663251": { "compartment": "compartment_70101", "id": "reaction_10663251", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10598398", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_109496" ] }, "reaction_10598857": { "compartment": "compartment_5460", "id": "reaction_10598857", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10665960": { "compartment": "compartment_70101", "id": "reaction_10665960", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10620182", "catalyst" ], [ "species_10665958", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "LigandDisplayForward?ligandId=6625", "LigandDisplayForward?ligandId=10641", "LigandDisplayForward?ligandId=10219", "Q18425", "WBGene00007918", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10633210": { "compartment": "compartment_171062", "id": "reaction_10633210", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806180" ], "modifiers": [ [ "species_10633077", "catalyst" ] ], "additional_components": [ "Q23083", "WBGene00022501", "O45318", "WBGene00022501" ] }, "reaction_10620172": { "compartment": "compartment_70101", "id": "reaction_10620172", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10620169", "catalyst" ] ], "additional_components": [ "Q7Z139", "WBGene00002044", "G5ED45", "WBGene00002043", "Q9XWE9", "WBGene00006505" ] }, "reaction_10603843": { "compartment": "compartment_70101", "id": "reaction_10603843", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10603840", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10604119": { "compartment": "compartment_70101", "id": "reaction_10604119", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10604116", "catalyst" ] ], "additional_components": [ "species_109382", "species_109366", "species_727810", "species_109378", "species_109402", "species_83928", "CHEBI:17562", "CHEBI:16704", "CHEBI:16450", "CHEBI:15698", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775", "species_109496" ] }, "reaction_10658877": { "compartment": "compartment_70101", "id": "reaction_10658877", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10604790" ], "products": [ "species_10604793", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10613692": { "compartment": "compartment_984", "id": "reaction_10613692", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10602198": { "compartment": "compartment_70101", "id": "reaction_10602198", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10602195", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83927", "CHEBI:17172", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_109496" ] }, "reaction_10664494": { "compartment": "compartment_17963", "id": "reaction_10664494", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605607" ], "products": [ "species_9605394", "species_205689" ], "modifiers": [ [ "species_10664434", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10633555": { "compartment": "compartment_70101", "id": "reaction_10633555", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10633552", "catalyst" ] ], "additional_components": [ "Q93644", "WBGene00009262", "O02167", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10601623": { "compartment": "compartment_70101", "id": "reaction_10601623", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10601620", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10599804": { "compartment": "compartment_5460", "id": "reaction_10599804", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10603975": { "compartment": "compartment_5460", "id": "reaction_10603975", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77330", "species_113526" ], "products": [ "species_77328", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603917", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10602168": { "compartment": "compartment_70101", "id": "reaction_10602168", "reactome": "R-CEL-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10602165", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10614865": { "compartment": "compartment_70101", "id": "reaction_10614865", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10614862", "catalyst" ] ], "additional_components": [ "species_216667", "G5EFT4", "WBGene00016589" ] }, "reaction_10633254": { "compartment": "compartment_171062", "id": "reaction_10633254", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10633251", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q9N589", "WBGene00003475" ] }, "reaction_10633615": { "compartment": "compartment_70101", "id": "reaction_10633615", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10633612", "catalyst" ] ], "additional_components": [ "G5ED01", "WBGene00012148", "species_29360" ] }, "reaction_10651384": { "compartment": "compartment_5460", "id": "reaction_10651384", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10599091", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10599083": { "compartment": "compartment_5460", "id": "reaction_10599083", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10613678": { "compartment": "compartment_70101", "id": "reaction_10613678", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10613675", "catalyst" ] ], "additional_components": [ "P90986", "WBGene00000296", "species_113531" ] }, "reaction_10649079": { "compartment": "compartment_5460", "id": "reaction_10649079", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649066", "species_113526" ], "products": [ "species_29362", "species_113529", "species_10649049" ], "modifiers": [ [ "species_10649076", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10656390": { "compartment": "compartment_70101", "id": "reaction_10656390", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656386", "species_10633085" ], "products": [ "species_10656388" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10649087": { "compartment": "compartment_12045", "id": "reaction_10649087", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694080", "species_29356" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10649084", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10617777": { "compartment": "compartment_17951", "id": "reaction_10617777", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10617774", "catalyst" ] ], "additional_components": [ "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10643266": { "compartment": "compartment_70101", "id": "reaction_10643266", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_202124", "species_10643261" ], "products": [ "species_29366", "species_432031", "species_10643259" ], "modifiers": [ [ "species_10643261", "catalyst" ] ], "additional_components": [ "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185" ] }, "reaction_10611257": { "compartment": "compartment_70101", "id": "reaction_10611257", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "species_113531", "Q95ZW2", "WBGene00017272" ] }, "reaction_10603987": { "compartment": "compartment_5460", "id": "reaction_10603987", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77337", "species_113596" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10603984", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10604559": { "compartment": "compartment_70101", "id": "reaction_10604559", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10604554", "catalyst" ] ], "additional_components": [ "species_727810", "species_76577", "species_109378", "species_109386", "species_29370", "CHEBI:58069", "CHEBI:57667", "CHEBI:58593", "Q09629", "WBGene00014058" ] }, "reaction_10613762": { "compartment": "compartment_984", "id": "reaction_10613762", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_209818", "species_352030", "species_351628" ], "modifiers": [ [ "species_10613753", "catalyst" ] ], "additional_components": [ "P34273", "WBGene00015334", "species_73524" ] }, "reaction_10643233": { "compartment": "compartment_70101", "id": "reaction_10643233", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10643230", "catalyst" ] ], "additional_components": [ "A0A3P6NP42", "WBGene00018632", "Q21333", "WBGene00010666" ] }, "reaction_10657675": { "compartment": "compartment_984", "id": "reaction_10657675", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851462", "species_109276" ], "products": [ "species_109277", "species_351626", "species_8851461" ], "modifiers": [ [ "species_10657672", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:58280", "CHEBI:58069", "species_205687", "species_727810", "species_29602", "species_109402", "species_113578", "Q9XU84", "WBGene00010697", "species_74016", "species_109496" ] }, "reaction_10665627": { "compartment": "compartment_70101", "id": "reaction_10665627", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10610506", "catalyst" ] ], "additional_components": [ "Q20538", "WBGene00018566", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568" ] }, "reaction_10632920": { "compartment": "compartment_876", "id": "reaction_10632920", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10632917", "catalyst" ] ], "additional_components": [ "WBGene00015283" ] }, "reaction_10656848": { "compartment": "compartment_876", "id": "reaction_10656848", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10656845", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10660188": { "compartment": "compartment_70101", "id": "reaction_10660188", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10660185", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10599086": { "compartment": "compartment_5460", "id": "reaction_10599086", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599080", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10625272": { "compartment": "compartment_70101", "id": "reaction_10625272", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10625263", "catalyst" ] ], "additional_components": [ "Q8MP09", "WBGene00010984" ] }, "reaction_10648833": { "compartment": "compartment_70101", "id": "reaction_10648833", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10648830", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10602145": { "compartment": "compartment_70101", "id": "reaction_10602145", "reactome": "R-CEL-74213", "name": "APRT catalyzes the conversion of adenine to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10602142", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10615271": { "compartment": "compartment_70101", "id": "reaction_10615271", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10615268", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10636569": { "compartment": "compartment_5460", "id": "reaction_10636569", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636565", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10636563" ], "modifiers": [], "additional_components": [ "Q9U1X0", "WBGene00013376", "species_113596", "Q9U1X0", "WBGene00013376", "species_31649" ] }, "reaction_10634926": { "compartment": "compartment_70101", "id": "reaction_10634926", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023974", "species_29356" ], "products": [ "species_1629770", "species_29372" ], "modifiers": [ [ "species_10633572", "catalyst" ] ], "additional_components": [ "CHEBI:62922", "species_1629740", "Q95XC4", "WBGene00022366", "species_266099", "species_109496" ] }, "reaction_10613746": { "compartment": "compartment_876", "id": "reaction_10613746", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10601727": { "compartment": "compartment_7660", "id": "reaction_10601727", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10601724", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10636096": { "compartment": "compartment_70101", "id": "reaction_10636096", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_2142716", "species_29356", "species_111745" ], "modifiers": [ [ "species_10636093", "catalyst" ] ], "additional_components": [ "Q95003", "WBGene00007517", "Q9N2X2", "WBGene00022377", "A8WFK6", "WBGene00019846", "Q93204", "WBGene00007516" ] }, "reaction_10650343": { "compartment": "compartment_70101", "id": "reaction_10650343", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10650340", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150", "species_109496" ] }, "reaction_10632912": { "compartment": "compartment_876", "id": "reaction_10632912", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429807" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10632909", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10630220": { "compartment": "compartment_5460", "id": "reaction_10630220", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630218", "species_113531" ], "products": [ "species_10630201" ], "modifiers": [], "additional_components": [ "O45948", "WBGene00012885", "O61741", "WBGene00015021", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998", "O45948", "WBGene00012885", "O61741", "WBGene00015021", "species_113531", "Q9TY03", "WBGene00001486", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10632619": { "compartment": "compartment_161320", "id": "reaction_10632619", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10632616", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10623707": { "compartment": "compartment_70101", "id": "reaction_10623707", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10623704", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10638225": { "compartment": "compartment_5460", "id": "reaction_10638225", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10638222", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10620552": { "compartment": "compartment_876", "id": "reaction_10620552", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10620549", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q20735", "WBGene00004893", "Q9TYV2", "WBGene00021075", "Q965Q4", "WBGene00004894" ] }, "reaction_10599065": { "compartment": "compartment_70101", "id": "reaction_10599065", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10599062", "catalyst" ] ], "additional_components": [ "Q9NAE2", "WBGene00013103", "species_29360" ] }, "reaction_10613764": { "compartment": "compartment_984", "id": "reaction_10613764", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10656409": { "compartment": "compartment_70101", "id": "reaction_10656409", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10656404", "catalyst" ] ], "additional_components": [ "Q9TXP3", "WBGene00003477", "Q9N589", "WBGene00003475" ] }, "reaction_10614996": { "compartment": "compartment_984", "id": "reaction_10614996", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10613665", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "H2KZ53", "WBGene00017968", "Q20616", "WBGene00009897" ] }, "reaction_10633833": { "compartment": "compartment_876", "id": "reaction_10633833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10633830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10603957": { "compartment": "compartment_5460", "id": "reaction_10603957", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77300", "species_113526" ], "products": [ "species_77302", "species_29362", "species_113529" ], "modifiers": [ [ "species_10603934", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10630813": { "compartment": "compartment_876", "id": "reaction_10630813", "reactome": "R-CEL-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10656977": { "compartment": "compartment_12045", "id": "reaction_10656977", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6814253", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10656974", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10648910": { "compartment": "compartment_876", "id": "reaction_10648910", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351626", "species_352327" ], "products": [ "species_351629", "species_351628" ], "modifiers": [ [ "species_10648907", "catalyst" ] ], "additional_components": [ "WBGene00000253" ] }, "reaction_10598764": { "compartment": "compartment_70101", "id": "reaction_10598764", "reactome": "R-CEL-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10598761", "catalyst" ] ], "additional_components": [ "O16924", "WBGene00003816" ] }, "reaction_10632599": { "compartment": "compartment_161320", "id": "reaction_10632599", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10632596", "catalyst" ] ], "additional_components": [ "O76632", "WBGene00019225", "Q27526", "WBGene00011832" ] }, "reaction_10650163": { "compartment": "compartment_70101", "id": "reaction_10650163", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29452" ], "products": [ "species_110096", "species_6785915" ], "modifiers": [ [ "species_10650160", "catalyst" ] ], "additional_components": [ "Q20086", "WBGene00009450", "Q9TXZ4", "WBGene00019234", "O16243", "WBGene00015739", "O16915", "WBGene00017332", "Q21603", "WBGene00010904", "Q9GYR7", "WBGene00016013", "P91039", "WBGene00015692", "Q22770", "WBGene00012013", "Q23334", "WBGene00013904", "O44149", "WBGene00016762", "O16506", "WBGene00015369", "Q93242", "WBGene00007650", "O18009", "WBGene00011340", "O16922", "WBGene00017336", "G5EES5", "WBGene00009255", "Q23335", "WBGene00013905", "O17401", "WBGene00017315", "Q22181", "WBGene00011453", "Q9TYY5", "WBGene00019515", "Q10941", "WBGene00015141", "P91038", "WBGene00015693", "O16916", "WBGene00017333", "O01616", "WBGene00020593", "O17123", "WBGene00017959", "Q22295", "WBGene00011564", "Q86S61", "WBGene00021464", "Q22180", "WBGene00011452", "G5EGK7", "WBGene00013901", "P34317", "WBGene00007402", "Q17403", "WBGene00007072", "H2KYQ0", "WBGene00015695", "O01614", "WBGene00020592", "Q9TXZ3", "WBGene00019235", "P91326", "WBGene00019235", "Q52GY8", "WBGene00044286", "O16510", "WBGene00019235", "Q23333", "WBGene00013903", "Q18629", "WBGene00008097", "Q17399", "WBGene00007070", "O45109", "WBGene00018931", "Q19082", "WBGene00017154", "A5JYT6", "WBGene00007422", "D5MCT5", "WBGene00008485", "Q9TXZ5", "WBGene00019233", "Q23323", "WBGene00013900", "H2KZP8", "WBGene00017329", "Q18470", "WBGene00007946", "Q17404", "WBGene00007073", "O16914", "WBGene00017331", "O17757", "WBGene00008486", "O01558", "WBGene00018543", "Q23336", "WBGene00013906", "P91037", "WBGene00015694", "O16276", "WBGene00018206", "Q965X5", "WBGene00021372", "Q3S1L2", "WBGene00020594", "O01617", "WBGene00020587", "A0A061AKV1", "WBGene00007885", "H2L0C9", "WBGene00021709", "Q18081", "WBGene00015965", "O16988", "WBGene00020182", "Q9TYY4", "WBGene00019516", "Q9TXZ6", "WBGene00019232", "Q21706", "WBGene00011006" ] }, "reaction_10604827": { "compartment": "compartment_70101", "id": "reaction_10604827", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601707", "species_8866401" ], "products": [ "species_8866399", "species_29356", "species_10601705" ], "modifiers": [ [ "species_10604824", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00020917", "WBGene00020917", "Q03604", "WBGene00004391", "species_912516", "P42170", "WBGene00004392" ] }, "reaction_10643238": { "compartment": "compartment_70101", "id": "reaction_10643238", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643235", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10643204": { "compartment": "compartment_70101", "id": "reaction_10643204", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643195", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10642609": { "compartment": "compartment_70101", "id": "reaction_10642609", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642600" ], "products": [ "species_10642607" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10642621": { "compartment": "compartment_70101", "id": "reaction_10642621", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642605", "species_10642617" ], "products": [ "species_10642619" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q95QM5", "WBGene00006839", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073" ] }, "reaction_10643246": { "compartment": "compartment_70101", "id": "reaction_10643246", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10643243", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10660687": { "compartment": "compartment_70101", "id": "reaction_10660687", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10660684", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29612", "species_29444", "species_29468", "WBGene00021546" ] }, "reaction_10643218": { "compartment": "compartment_70101", "id": "reaction_10643218", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10643215", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10606449": { "compartment": "compartment_7660", "id": "reaction_10606449", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10606444" ], "products": [ "species_113582", "species_10606447" ], "modifiers": [ [ "species_10605870", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10617413": { "compartment": "compartment_70616", "id": "reaction_10617413", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10617410", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281", "O17895", "WBGene00001813" ] }, "reaction_10647412": { "compartment": "compartment_70101", "id": "reaction_10647412", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_352022", "species_29356" ], "products": [ "species_29370", "species_188972", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10630680": { "compartment": "compartment_70101", "id": "reaction_10630680", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10630677", "catalyst" ] ], "additional_components": [ "Q9U2G5", "WBGene00003413", "G5EFP3", "WBGene00003410", "Q3S1M2", "WBGene00003407", "Q19625", "WBGene00003412", "G5EE72", "WBGene00003411", "Q9XW61", "WBGene00003414", "Q95QV2", "WBGene00000477", "Q19048", "WBGene00003409" ] }, "reaction_10658922": { "compartment": "compartment_70101", "id": "reaction_10658922", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658885" ], "products": [ "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10630270": { "compartment": "compartment_17906", "id": "reaction_10630270", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_113592", "species_29356" ], "products": [ "species_1369027", "species_29370", "species_29372" ], "modifiers": [ [ "species_10630267", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10658934": { "compartment": "compartment_876", "id": "reaction_10658934", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883" ], "products": [ "species_10617481" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10642580": { "compartment": "compartment_70101", "id": "reaction_10642580", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5223341", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_5223344" ], "modifiers": [ [ "species_10642577", "catalyst" ] ], "additional_components": [ "O44897", "WBGene00001819" ] }, "reaction_10642630": { "compartment": "compartment_70101", "id": "reaction_10642630", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10642626", "species_10601197" ], "products": [ "species_10642628" ], "modifiers": [], "additional_components": [ "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19554", "WBGene00006512", "Q21230", "WBGene00010560" ] }, "reaction_10617438": { "compartment": "compartment_17947", "id": "reaction_10617438", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10617435", "catalyst" ] ], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061" ] }, "reaction_10617484": { "compartment": "compartment_876", "id": "reaction_10617484", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_29356" ], "products": [ "species_29370", "species_425425", "species_29372" ], "modifiers": [ [ "species_10617481", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10658920": { "compartment": "compartment_12045", "id": "reaction_10658920", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658883", "species_10658909" ], "products": [ "species_10658915" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10617469": { "compartment": "compartment_17947", "id": "reaction_10617469", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617467", "species_10617443" ], "products": [ "species_10617435", "species_10617443", "species_10617465" ], "modifiers": [], "additional_components": [ "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "P34453", "WBGene00004201", "WBGene00004193", "Q18598", "WBGene00004059", "O45730", "WBGene00004061", "WBGene00004193", "WBGene00004201" ] }, "reaction_10658918": { "compartment": "compartment_12045", "id": "reaction_10658918", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658915", "species_10597908" ], "products": [ "species_10658911" ], "modifiers": [ [ "species_10658915", "catalyst" ] ], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10658913": { "compartment": "compartment_12045", "id": "reaction_10658913", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10658911", "species_29356" ], "products": [ "species_29370", "species_10658885", "species_29372", "species_10658909" ], "modifiers": [], "additional_components": [ "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "Q19625", "WBGene00003412", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q95QV2", "WBGene00000477", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P0CG71", "WBGene00006727", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "A3QMC6", "WBGene00016592", "P54812", "WBGene00008053", "Q09463", "WBGene00004381", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q93561", "WBGene00000843" ] }, "reaction_10647530": { "compartment": "compartment_70101", "id": "reaction_10647530", "reactome": "R-CEL-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10647527", "catalyst" ] ], "additional_components": [ "Q9TXV8", "WBGene00000022", "Q9XW49", "WBGene00000023", "Q1RS86", "WBGene00000020", "P34358", "WBGene00000421" ] }, "reaction_10615447": { "compartment": "compartment_70101", "id": "reaction_10615447", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615440" ], "products": [ "species_10615444", "species_10615442" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10625999": { "compartment": "compartment_20699", "id": "reaction_10625999", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_113592", "species_29356" ], "products": [ "species_29370", "species_167012", "species_29372" ], "modifiers": [ [ "species_10625996", "catalyst" ] ], "additional_components": [ "G5EDU1", "WBGene00004063", "species_109496" ] }, "reaction_10638045": { "compartment": "compartment_17927", "id": "reaction_10638045", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889081", "species_113529" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10638042", "catalyst" ] ], "additional_components": [ "species_74113", "species_425815", "species_74113", "species_425815", "WBGene00009617" ] }, "reaction_10619535": { "compartment": "compartment_171062", "id": "reaction_10619535", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10619530", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10622391": { "compartment": "compartment_70101", "id": "reaction_10622391", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637543": { "compartment": "compartment_70101", "id": "reaction_10637543", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637540", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10626047": { "compartment": "compartment_876", "id": "reaction_10626047", "reactome": "R-CEL-937311", "name": "ATP12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10626044", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10656840": { "compartment": "compartment_70101", "id": "reaction_10656840", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10656837", "catalyst" ] ], "additional_components": [ "Q7JMM5", "WBGene00017515", "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q94187", "WBGene00017515" ] }, "reaction_10638040": { "compartment": "compartment_984", "id": "reaction_10638040", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10638037", "catalyst" ] ], "additional_components": [ "Q9XU88", "WBGene00010214", "Q20273", "WBGene00009617", "G5EFS0", "WBGene00009618" ] }, "reaction_10620374": { "compartment": "compartment_876", "id": "reaction_10620374", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10620371", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10629117": { "compartment": "compartment_984", "id": "reaction_10629117", "reactome": "R-CEL-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10629114", "catalyst" ] ], "additional_components": [ "species_216667", "Q10462", "WBGene00000283" ] }, "reaction_10615975": { "compartment": "compartment_876", "id": "reaction_10615975", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_113538", "species_159549", "WBGene00012804" ] }, "reaction_10637530": { "compartment": "compartment_70101", "id": "reaction_10637530", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10637458", "species_113592", "species_10597908" ], "products": [ "species_29370", "species_10637478", "species_947590" ], "modifiers": [ [ "species_10637516", "catalyst" ], [ "species_10637522", "catalyst" ] ], "additional_components": [ "Q19777", "WBGene00009109", "WBGene00006727", "Q19777", "WBGene00009109", "G4S4W1", "WBGene00016980", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "Q07292", "WBGene00003030", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "WBGene00006941" ] }, "reaction_10626107": { "compartment": "compartment_876", "id": "reaction_10626107", "reactome": "R-CEL-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947594", "species_113592", "species_29356" ], "products": [ "species_29370", "species_947588", "species_29372" ], "modifiers": [ [ "species_10626104", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1524083", "species_1500646", "species_1524083", "P91203", "WBGene00017174", "Q9U280", "WBGene00013034", "O18182", "WBGene00012360", "U4PBV8", "WBGene00019166", "Q7JPE3", "WBGene00020784", "G5EBH1", "WBGene00009498" ] }, "reaction_10615157": { "compartment": "compartment_876", "id": "reaction_10615157", "reactome": "R-CEL-352364", "name": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352036", "species_74113" ], "products": [ "species_83910", "species_352359", "species_74113", "species_29432" ], "modifiers": [ [ "species_10615150", "catalyst" ] ], "additional_components": [ "species_29432", "species_111707", "species_352002", "species_351990", "species_29432", "species_111707", "species_352002", "species_351990", "WBGene00001622" ] }, "reaction_10637617": { "compartment": "compartment_70101", "id": "reaction_10637617", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2730999" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10637614", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10659515": { "compartment": "compartment_876", "id": "reaction_10659515", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10659509", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10625831": { "compartment": "compartment_947586", "id": "reaction_10625831", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10625284", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "species_936901" ] }, "reaction_10642981": { "compartment": "compartment_70101", "id": "reaction_10642981", "reactome": "R-CEL-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10642978", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10643209": { "compartment": "compartment_70101", "id": "reaction_10643209", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622382", "catalyst" ], [ "species_10643207", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q20734", "WBGene00043980", "WBGene00002881" ] }, "reaction_10662986": { "compartment": "compartment_70101", "id": "reaction_10662986", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662983", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10619506": { "compartment": "compartment_876", "id": "reaction_10619506", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112", "species_74126" ], "modifiers": [ [ "species_10619503", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10663007": { "compartment": "compartment_70101", "id": "reaction_10663007", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10663004", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10620458": { "compartment": "compartment_876", "id": "reaction_10620458", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10613743", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10616007": { "compartment": "compartment_876", "id": "reaction_10616007", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10616004", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_29432", "species_113538", "species_159549", "O45936", "WBGene00012804", "Q18595", "WBGene00016628", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q9XX44", "WBGene00012629" ] }, "reaction_10620122": { "compartment": "compartment_201753", "id": "reaction_10620122", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10620119", "catalyst" ] ], "additional_components": [ "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556" ] }, "reaction_10620250": { "compartment": "compartment_201753", "id": "reaction_10620250", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_428592" ], "products": [ "species_70106", "species_428632" ], "modifiers": [ [ "species_10620247", "catalyst" ] ], "additional_components": [ "species_352003", "species_159549", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10637656": { "compartment": "compartment_70101", "id": "reaction_10637656", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637653", "catalyst" ] ], "additional_components": [ "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528", "G5EG93", "WBGene00000529", "Q9BMK9", "WBGene00000530" ] }, "reaction_10639280": { "compartment": "compartment_70101", "id": "reaction_10639280", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639277", "catalyst" ] ], "additional_components": [ "P34586", "WBGene00006614", "G5EDR9", "WBGene00003838", "Q22374", "WBGene00003840", "Q8T666", "WBGene00000846", "O61220", "WBGene00003839", "Q20766", "WBGene00001796", "P34641", "WBGene00000425", "Q8I6Y9", "WBGene00006615", "G5EF09", "WBGene00004976", "Q23141", "WBGene00020972", "Q9N3Y9", "WBGene00003841", "G5ECM4", "WBGene00001795", "Q93971", "WBGene00001651", "Q19377", "WBGene00008731" ] }, "reaction_10620097": { "compartment": "compartment_876", "id": "reaction_10620097", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10620094", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "WBGene00003876" ] }, "reaction_10663009": { "compartment": "compartment_70101", "id": "reaction_10663009", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10637671": { "compartment": "compartment_70101", "id": "reaction_10637671", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637668", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10648663": { "compartment": "compartment_70101", "id": "reaction_10648663", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10648656", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10665480": { "compartment": "compartment_876", "id": "reaction_10665480", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665478", "species_351626" ], "products": [ "species_10637417" ], "modifiers": [], "additional_components": [ "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "Q10025", "WBGene00020897", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465" ] }, "reaction_10658135": { "compartment": "compartment_876", "id": "reaction_10658135", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658125" ], "products": [ "species_10658133" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10619627": { "compartment": "compartment_876", "id": "reaction_10619627", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10619624", "catalyst" ] ], "additional_components": [ "G5EBK1", "WBGene00003943", "H2L039", "WBGene00003734", "G5EDH8", "WBGene00003729", "P35449", "WBGene00003736", "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "O16452", "WBGene00003731" ] }, "reaction_10637666": { "compartment": "compartment_70101", "id": "reaction_10637666", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637661", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10637927": { "compartment": "compartment_70101", "id": "reaction_10637927", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10637915", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10658393": { "compartment": "compartment_876", "id": "reaction_10658393", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658389", "species_10637417" ], "products": [ "species_10658391" ], "modifiers": [], "additional_components": [ "Q7YZV6", "WBGene00006067", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "Q7YZV6", "WBGene00006067", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "Q20657", "WBGene00006065", "Q19958", "WBGene00006064" ] }, "reaction_10607855": { "compartment": "compartment_74700", "id": "reaction_10607855", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607851" ], "products": [ "species_10607853" ], "modifiers": [], "additional_components": [ "WBGene00020481", "WBGene00020481" ] }, "reaction_10637985": { "compartment": "compartment_70101", "id": "reaction_10637985", "reactome": "R-CEL-2855020", "name": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2855229" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10637970", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_74016", "catalyst" ], [ "species_10637983", "inhibitor" ], [ "species_10599651", "inhibitor" ] ], "additional_components": [ "Q20203", "WBGene00000822", "A8WHT8", "WBGene00010703", "A0A2C9C3E8", "WBGene00006801", "Q9U2Q8", "WBGene00001427", "O45405", "WBGene00001371", "Q8WQA4", "WBGene00001365", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10619715": { "compartment": "compartment_876", "id": "reaction_10619715", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_188972", "species_74126" ], "modifiers": [ [ "species_10619712", "catalyst" ] ], "additional_components": [ "Q09573", "WBGene00019289", "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205" ] }, "reaction_10660137": { "compartment": "compartment_12045", "id": "reaction_10660137", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660133" ], "products": [ "species_193384", "species_10660131" ], "modifiers": [], "additional_components": [ "species_8848047", "P34389", "WBGene00003562", "WBGene00003562" ] }, "reaction_10637444": { "compartment": "compartment_70101", "id": "reaction_10637444", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10637417", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_10637442", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "Q18077", "WBGene00015957", "species_70106", "P91100", "WBGene00016066", "G5EFH3", "WBGene00010334", "Q10025", "WBGene00020897", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "G5EFH3", "WBGene00010334", "P91103", "WBGene00016063", "G3MU02", "WBGene00007775", "O01664", "WBGene00020903", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q18077", "WBGene00015957", "O45402", "WBGene00009073", "Q8MPW0", "WBGene00011891", "G5EGI5", "WBGene00001465", "P91100", "WBGene00016066" ] }, "reaction_10660129": { "compartment": "compartment_161320", "id": "reaction_10660129", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10660125" ], "products": [ "species_10660127" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_8848047", "O17271", "WBGene00006452" ] }, "reaction_10620016": { "compartment": "compartment_876", "id": "reaction_10620016", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620013", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10662860": { "compartment": "compartment_70101", "id": "reaction_10662860", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10662857", "catalyst" ] ], "additional_components": [ "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "species_29612", "CHEBI:28229", "species_113585", "species_29444", "species_29468", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10620008": { "compartment": "compartment_876", "id": "reaction_10620008", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10620005", "catalyst" ] ], "additional_components": [ "O17404", "WBGene00017312", "O45220", "WBGene00007141", "Q17454", "WBGene00015054", "P91840", "WBGene00012285", "Q17455", "WBGene00015055", "Q18697", "WBGene00016739" ] }, "reaction_10660180": { "compartment": "compartment_12045", "id": "reaction_10660180", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_76194", "species_8876704" ], "modifiers": [ [ "species_10660175", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10625823": { "compartment": "compartment_984", "id": "reaction_10625823", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_912516", "species_917828" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10625820", "catalyst" ] ], "additional_components": [ "P34465", "WBGene00018210", "O16271", "WBGene00018210", "species_71185", "O16272", "WBGene00018210" ] }, "reaction_10615166": { "compartment": "compartment_876", "id": "reaction_10615166", "reactome": "R-CEL-352385", "name": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_83910", "species_74113", "species_29432" ], "products": [ "species_29472", "species_83910", "species_352036", "species_74113" ], "modifiers": [ [ "species_10615161", "catalyst" ] ], "additional_components": [ "WBGene00001622" ] }, "reaction_10626007": { "compartment": "compartment_20699", "id": "reaction_10626007", "reactome": "R-CEL-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10626004", "catalyst" ] ], "additional_components": [ "WBGene00000834" ] }, "reaction_10648767": { "compartment": "compartment_70101", "id": "reaction_10648767", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597908", "species_10648660" ], "products": [ "species_10648758" ], "modifiers": [ [ "species_10648764", "catalyst" ] ], "additional_components": [ "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807" ] }, "reaction_10648852": { "compartment": "compartment_70101", "id": "reaction_10648852", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10648849", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q27533", "WBGene00012341", "Q21286", "WBGene00019493" ] }, "reaction_10620426": { "compartment": "compartment_876", "id": "reaction_10620426", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10620423", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10666181": { "compartment": "compartment_876", "id": "reaction_10666181", "reactome": "R-CEL-9727198", "name": "ATP4A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_74126", "species_29356" ], "products": [ "species_29370", "species_29804", "species_351626", "species_29372" ], "modifiers": [ [ "species_10666178", "catalyst" ] ], "additional_components": [ "O16436", "WBGene00015338", "Q9XUG9", "WBGene00008074", "Q93235", "WBGene00007646", "G5EFV6", "WBGene00007248", "Q9XUY5", "WBGene00010117", "G5EBE7", "WBGene00013672", "P90735", "WBGene00001137", "O16331", "WBGene00015660" ] }, "reaction_10631304": { "compartment": "compartment_70101", "id": "reaction_10631304", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_71067" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10621144", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10619675": { "compartment": "compartment_876", "id": "reaction_10619675", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10619672", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10665971": { "compartment": "compartment_70101", "id": "reaction_10665971", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10639225", "catalyst" ] ], "additional_components": [ "G5EDR9", "WBGene00003838", "Q9N3Y9", "WBGene00003841", "Q22374", "WBGene00003840", "O61220", "WBGene00003839" ] }, "reaction_10625842": { "compartment": "compartment_947586", "id": "reaction_10625842", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_352327", "species_435347" ], "products": [ "species_912516", "species_109276" ], "modifiers": [ [ "species_10621416", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "Q8IA95", "WBGene00021354", "O44607", "WBGene00019977", "CHEBI:28694" ] }, "reaction_10619528": { "compartment": "compartment_172574", "id": "reaction_10619528", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_425999" ], "products": [ "species_70106", "species_425977" ], "modifiers": [ [ "species_10619525", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10619514": { "compartment": "compartment_876", "id": "reaction_10619514", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_425815" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10619511", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10662981": { "compartment": "compartment_70101", "id": "reaction_10662981", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10662978", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10619639": { "compartment": "compartment_20699", "id": "reaction_10619639", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10619636", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10619666": { "compartment": "compartment_876", "id": "reaction_10619666", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_74126" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10619663", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10637918": { "compartment": "compartment_70101", "id": "reaction_10637918", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10637915", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q19978", "WBGene00009340", "Q18303", "WBGene00007808", "O16779", "WBGene00206487", "O17205", "WBGene00015288", "P34319", "WBGene00007404", "O18304", "WBGene00014103", "Q17529", "WBGene00007204", "Q7YXH3", "WBGene00020046", "J7RNL4", "WBGene00220250", "Q22566", "WBGene00020559", "Q17851", "WBGene00015628", "Q21973", "WBGene00011258", "O45435", "WBGene00009323", "Q23369", "WBGene00013921", "O45363", "WBGene00008821", "A5JYR2", "WBGene00014989", "O18303", "WBGene00014102", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "O17671", "WBGene00008186", "Q17528", "WBGene00007203", "O17206", "WBGene00015286", "P34672", "WBGene00022797", "Q94175", "WBGene00016613", "O62095", "WBGene00007988" ] }, "reaction_10650003": { "compartment": "compartment_1660541", "id": "reaction_10650003", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649973" ], "products": [ "species_10650001" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246" ] }, "reaction_10650005": { "compartment": "compartment_1660541", "id": "reaction_10650005", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10650001" ], "products": [ "species_10649999" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "Q7JP80", "WBGene00020481", "P90961", "WBGene00020246", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246" ] }, "reaction_10620099": { "compartment": "compartment_876", "id": "reaction_10620099", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_428027", "species_351626", "species_74113" ], "products": [ "species_70106", "species_83910", "species_427997", "species_74126" ], "modifiers": [ [ "species_10613848", "catalyst" ] ], "additional_components": [ "species_6810061", "species_427963", "species_113552", "species_6810061", "species_427963", "species_113552", "Q21353", "WBGene00001621", "Q22682", "WBGene00001622", "Q10901", "WBGene00001620", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q21751", "WBGene00001624" ] }, "reaction_10630870": { "compartment": "compartment_70101", "id": "reaction_10630870", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528", "species_29356" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10630867", "catalyst" ] ], "additional_components": [ "species_216667", "Q21614", "WBGene00000282" ] }, "reaction_10622388": { "compartment": "compartment_70101", "id": "reaction_10622388", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622384" ], "products": [ "species_10622382", "species_113592" ], "modifiers": [], "additional_components": [ "species_113592", "Q20734", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10660135": { "compartment": "compartment_161320", "id": "reaction_10660135", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660127", "species_10660131" ], "products": [ "species_10660133", "species_10660125" ], "modifiers": [], "additional_components": [ "species_8848047", "O17271", "WBGene00006452", "WBGene00003562", "species_8848047", "P34389", "WBGene00003562", "WBGene00006452" ] }, "reaction_10648755": { "compartment": "compartment_5460", "id": "reaction_10648755", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10648752", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10620088": { "compartment": "compartment_12045", "id": "reaction_10620088", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_156540" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10620064", "catalyst" ], [ "species_10620086", "catalyst" ] ], "additional_components": [ "WBGene00004736", "Q09980", "WBGene00017394", "Q09665", "WBGene00006583", "G5EF37", "WBGene00003934", "O62305", "WBGene00006779", "Q94288", "WBGene00000287", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "species_74016", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "G5EDZ8", "WBGene00000288" ] }, "reaction_10620519": { "compartment": "compartment_876", "id": "reaction_10620519", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10620513", "catalyst" ] ], "additional_components": [ "WBGene00014092" ] }, "reaction_10648841": { "compartment": "compartment_70101", "id": "reaction_10648841", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10648838", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10658121": { "compartment": "compartment_70101", "id": "reaction_10658121", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_71285", "species_2162265" ], "modifiers": [ [ "species_10658118", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10660027": { "compartment": "compartment_70101", "id": "reaction_10660027", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10660024", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10648776": { "compartment": "compartment_70101", "id": "reaction_10648776", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613629", "species_10648772" ], "products": [ "species_10648774" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10622386": { "compartment": "compartment_70101", "id": "reaction_10622386", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622382", "species_113592" ], "products": [ "species_10622384" ], "modifiers": [], "additional_components": [ "Q20734", "WBGene00043980", "species_113592", "Q20734", "WBGene00043980" ] }, "reaction_10637553": { "compartment": "compartment_70101", "id": "reaction_10637553", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10637548", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10648658": { "compartment": "compartment_70101", "id": "reaction_10648658", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648654", "species_5690881" ], "products": [ "species_10648656" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10607567": { "compartment": "compartment_70101", "id": "reaction_10607567", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607560" ], "products": [ "species_29370", "species_10607562" ], "modifiers": [ [ "species_10607564", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00006940" ] }, "reaction_10607608": { "compartment": "compartment_13231", "id": "reaction_10607608", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607606" ], "products": [ "species_10607600" ], "modifiers": [], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10638343": { "compartment": "compartment_70101", "id": "reaction_10638343", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605884" ], "products": [ "species_10605870" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10638290": { "compartment": "compartment_70101", "id": "reaction_10638290", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10638283" ], "products": [ "species_10638287", "species_29370", "species_10605884" ], "modifiers": [ [ "species_10638283", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198", "WBGene00010198", "WBGene00004043", "Q9N2L7", "WBGene00004043", "H2FLK2", "WBGene00010198" ] }, "reaction_10607552": { "compartment": "compartment_13231", "id": "reaction_10607552", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607520" ], "products": [ "species_10607550" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10638363": { "compartment": "compartment_7660", "id": "reaction_10638363", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10605870" ], "products": [ "species_10638345", "species_113550" ], "modifiers": [ [ "species_10638360", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747" ] }, "reaction_10607604": { "compartment": "compartment_7660", "id": "reaction_10607604", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607600", "species_29358" ], "products": [ "species_113582", "species_10607602" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10607584": { "compartment": "compartment_7660", "id": "reaction_10607584", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10607532" ], "products": [ "species_113582", "species_10607573" ], "modifiers": [ [ "species_10601816", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10658258": { "compartment": "compartment_7660", "id": "reaction_10658258", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10630226", "species_77087" ], "products": [ "species_10658250", "species_77502" ], "modifiers": [ [ "species_10658255", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007137" ] }, "reaction_10658266": { "compartment": "compartment_7660", "id": "reaction_10658266", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658250", "species_113518" ], "products": [ "species_8857797", "species_10630226" ], "modifiers": [ [ "species_10658263", "catalyst" ] ], "additional_components": [ "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "A0A1N7SYW5", "WBGene00018373", "Q09543", "WBGene00003901", "G5EGK8", "WBGene00002363", "G5EDR3", "WBGene00006352", "WBGene00007188" ] }, "reaction_10607569": { "compartment": "compartment_70101", "id": "reaction_10607569", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607556" ], "products": [ "species_10607560" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657946": { "compartment": "compartment_70101", "id": "reaction_10657946", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657941" ], "products": [ "species_10657884", "species_10597908" ], "modifiers": [ [ "species_10598108", "catalyst" ] ], "additional_components": [ "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "WBGene00006727", "O44156", "WBGene00003927", "O61792", "WBGene00004464", "Q22253", "WBGene00004465", "P91477", "WBGene00003950", "O76577", "WBGene00004467", "P46502", "WBGene00004503", "P90868", "WBGene00003953", "O17071", "WBGene00004504", "Q18787", "WBGene00004501", "O62102", "WBGene00003948", "Q20058", "WBGene00009445", "Q9XTT9", "WBGene00004506", "Q20938", "WBGene00004462", "P34286", "WBGene00003952", "O76371", "WBGene00004505", "Q95008", "WBGene00003926", "Q966I8", "WBGene00003947", "Q95PZ7", "WBGene00013435", "O61742", "WBGene00004466", "Q17971", "WBGene00007588", "Q9XUV0", "WBGene00003951", "Q95005", "WBGene00003925", "O16368", "WBGene00004502", "Q18115", "WBGene00004459", "Q10920", "WBGene00016623", "Q23237", "WBGene00003949", "Q9GZH5", "WBGene00004458", "Q19324", "WBGene00004461", "O45398", "WBGene00009064", "Q20585", "WBGene00004463", "Q09583", "WBGene00003928", "Q04908", "WBGene00004460", "Q23449", "WBGene00004468", "Q27488", "WBGene00003923", "O17586", "WBGene00003922", "Q9N599", "WBGene00003924" ] }, "reaction_10607598": { "compartment": "compartment_70101", "id": "reaction_10607598", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607558", "species_10607594" ], "products": [ "species_10607596" ], "modifiers": [], "additional_components": [ "WBGene00000405", "H2L0L4", "WBGene00020461", "P34638", "WBGene00000863", "H2L0L4", "WBGene00020461", "P34556", "WBGene00000405", "P34638", "WBGene00000863" ] }, "reaction_10607580": { "compartment": "compartment_13231", "id": "reaction_10607580", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607536" ], "products": [ "species_10607496" ], "modifiers": [ [ "species_10607578", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10657944": { "compartment": "compartment_70101", "id": "reaction_10657944", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657898", "species_10597908" ], "products": [ "species_10657941" ], "modifiers": [ [ "species_10657898", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320", "WBGene00006727", "Q17389", "WBGene00000836", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "G5EDL3", "WBGene00000098", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10640968": { "compartment": "compartment_70101", "id": "reaction_10640968", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10640966" ], "products": [ "species_29370", "species_10638281" ], "modifiers": [ [ "species_10607633", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10607619": { "compartment": "compartment_13231", "id": "reaction_10607619", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607518" ], "products": [ "species_10607548" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10657900": { "compartment": "compartment_70101", "id": "reaction_10657900", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657896", "species_10657884" ], "products": [ "species_10657898" ], "modifiers": [], "additional_components": [ "O01427", "WBGene00000099", "G5EDL3", "WBGene00000098", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "G5EDL3", "WBGene00000098", "Q23457", "WBGene00004320" ] }, "reaction_10607617": { "compartment": "compartment_70101", "id": "reaction_10607617", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607610" ], "products": [ "species_29370", "species_10607518" ], "modifiers": [ [ "species_10607614", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9N2L7", "WBGene00004043", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10658008": { "compartment": "compartment_171062", "id": "reaction_10658008", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658004", "species_10657982" ], "products": [ "species_10658006" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644", "WBGene00012894", "P91857", "WBGene00004268", "Q9U2D8", "WBGene00012894", "Q23165", "WBGene00000166", "CHEBI:15996", "A0A486WY48", "WBGene00012644" ] }, "reaction_10658113": { "compartment": "compartment_262783", "id": "reaction_10658113", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658104", "species_10658109", "species_10658098" ], "products": [ "species_10658111" ], "modifiers": [], "additional_components": [ "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "WBGene00044061", "WBGene00004274", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061", "O01803", "WBGene00004274" ] }, "reaction_10658051": { "compartment": "compartment_17938", "id": "reaction_10658051", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658049", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_111349", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271" ] }, "reaction_10658022": { "compartment": "compartment_17938", "id": "reaction_10658022", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658012", "species_29356" ], "products": [ "species_10658014", "species_29372" ], "modifiers": [ [ "species_10658012", "catalyst" ], [ "species_10658020", "catalyst" ] ], "additional_components": [ "CHEBI:15996", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "CHEBI:15996", "Q23146", "WBGene00004271", "WBGene00022880" ] }, "reaction_10658045": { "compartment": "compartment_20699", "id": "reaction_10658045", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658041", "species_10657417" ], "products": [ "species_10658043" ], "modifiers": [], "additional_components": [ "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "H2KZZ6", "WBGene00018075", "species_29438", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10657976": { "compartment": "compartment_24339", "id": "reaction_10657976", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657953", "species_29356" ], "products": [ "species_29372", "species_10657955" ], "modifiers": [ [ "species_10657953", "catalyst" ], [ "species_10657974", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "species_29420", "Q9U2C3", "WBGene00004284", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "O44873", "WBGene00019915", "H2KZ54", "WBGene00016292" ] }, "reaction_10658036": { "compartment": "compartment_262783", "id": "reaction_10658036", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658025", "species_10658032" ], "products": [ "species_10658034" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "O44873", "WBGene00019915", "species_29438" ] }, "reaction_10646156": { "compartment": "compartment_7660", "id": "reaction_10646156", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646152", "species_10604720" ], "products": [ "species_10646154" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q19196", "WBGene00017237", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10620944": { "compartment": "compartment_70101", "id": "reaction_10620944", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10620938", "species_10608669", "species_10619297" ], "products": [ "species_10620942", "species_10614982", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "species_29438", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "species_29420", "G5EFK4", "WBGene00000183" ] }, "reaction_10646797": { "compartment": "compartment_20699", "id": "reaction_10646797", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646793", "species_10625671", "species_10608649" ], "products": [ "species_10646795" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q8WQB3", "WBGene00000158", "Q17796", "WBGene00004101" ] }, "reaction_10643083": { "compartment": "compartment_263163", "id": "reaction_10643083", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10643079" ], "products": [ "species_10643081" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "P34574", "WBGene00011867", "species_5334668", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "Q9N4F3", "WBGene00000160", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P35602", "WBGene00006829" ] }, "reaction_10621011": { "compartment": "compartment_70101", "id": "reaction_10621011", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620942", "species_29438" ], "products": [ "species_10619299", "species_10608669", "species_29372", "species_29420", "species_10621008" ], "modifiers": [ [ "species_10620942", "catalyst" ] ], "additional_components": [ "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q8WQB3", "WBGene00000158", "Q94057", "WBGene00044062", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "P51485", "WBGene00000195", "Q22616", "WBGene00011872", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "O01755", "WBGene00000150", "Q22616", "WBGene00011872", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "O16369", "WBGene00000159", "P90961", "WBGene00020246", "P34387", "WBGene00007056", "Q95XH1", "WBGene00022077", "G5EGP8", "WBGene00000788", "Q19767", "WBGene00004898" ] }, "reaction_10612275": { "compartment": "compartment_70101", "id": "reaction_10612275", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612269" ], "products": [ "species_10612271", "species_10612273" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615087": { "compartment": "compartment_70101", "id": "reaction_10615087", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615078" ], "products": [ "species_10615082", "species_10615080" ], "modifiers": [ [ "species_10615084", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615118": { "compartment": "compartment_7660", "id": "reaction_10615118", "reactome": "R-CEL-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608315" ], "products": [ "species_10615095", "species_10615093" ], "modifiers": [ [ "species_10615115", "catalyst" ] ], "additional_components": [ "WBGene00009127", "WBGene00009127", "WBGene00009127", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611885": { "compartment": "compartment_70101", "id": "reaction_10611885", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611879" ], "products": [ "species_10611883", "species_10611881" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10611934": { "compartment": "compartment_70101", "id": "reaction_10611934", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611928" ], "products": [ "species_10611932", "species_10611930" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10612313": { "compartment": "compartment_70101", "id": "reaction_10612313", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612307" ], "products": [ "species_10612311", "species_10612309" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10612283": { "compartment": "compartment_70101", "id": "reaction_10612283", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612277" ], "products": [ "species_10612279", "species_10612281" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10614649": { "compartment": "compartment_7660", "id": "reaction_10614649", "reactome": "R-CEL-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614622" ], "products": [ "species_10614624", "species_10614626" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10664192": { "compartment": "compartment_13231", "id": "reaction_10664192", "reactome": "R-CEL-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10664190" ], "products": [ "species_10614646" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611908": { "compartment": "compartment_70101", "id": "reaction_10611908", "reactome": "R-CEL-201634", "name": "Caspase-mediated cleavage of FADK 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611901" ], "products": [ "species_10611903", "species_10611905" ], "modifiers": [ [ "species_10605385", "catalyst" ] ], "additional_components": [ "WBGene00002213", "WBGene00002213", "WBGene00002213", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611852": { "compartment": "compartment_70101", "id": "reaction_10611852", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611846" ], "products": [ "species_10611848", "species_10611850" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10664170": { "compartment": "compartment_7660", "id": "reaction_10664170", "reactome": "R-CEL-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605385" ], "products": [ "species_10615115" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10611844": { "compartment": "compartment_876", "id": "reaction_10611844", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611839" ], "products": [ "species_10611841" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10615122": { "compartment": "compartment_13231", "id": "reaction_10615122", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615080" ], "products": [ "species_10615120" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10614975": { "compartment": "compartment_70101", "id": "reaction_10614975", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614969" ], "products": [ "species_10614973", "species_10614971" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10611896": { "compartment": "compartment_70101", "id": "reaction_10611896", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611890" ], "products": [ "species_10611894", "species_10611892" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10611917": { "compartment": "compartment_70101", "id": "reaction_10611917", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611913" ], "products": [ "species_10611915" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10615065": { "compartment": "compartment_876", "id": "reaction_10615065", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615061" ], "products": [ "species_10615063" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10615059": { "compartment": "compartment_70101", "id": "reaction_10615059", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615053" ], "products": [ "species_10615057", "species_10615055" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10615091": { "compartment": "compartment_876", "id": "reaction_10615091", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615089" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10614657": { "compartment": "compartment_7660", "id": "reaction_10614657", "reactome": "R-CEL-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614651" ], "products": [ "species_10614653", "species_10614655" ], "modifiers": [ [ "species_10614646", "catalyst" ] ], "additional_components": [ "WBGene00003052", "WBGene00003052", "WBGene00003052", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "Q9TZP5", "WBGene00000820" ] }, "reaction_10615131": { "compartment": "compartment_70101", "id": "reaction_10615131", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615127" ], "products": [ "species_10615129" ], "modifiers": [ [ "species_10615072", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10614404": { "compartment": "compartment_70101", "id": "reaction_10614404", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604948" ], "products": [ "species_10614400", "species_10614402" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10615051": { "compartment": "compartment_876", "id": "reaction_10615051", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615047" ], "products": [ "species_10615049" ], "modifiers": [ [ "species_10605337", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10609819": { "compartment": "compartment_876", "id": "reaction_10609819", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10609816", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_188995", "species_70113", "species_29532", "species_188995", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q21381", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q20734", "WBGene00043980" ] }, "reaction_10609777": { "compartment": "compartment_876", "id": "reaction_10609777", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10609774", "catalyst" ] ], "additional_components": [ "O16547", "WBGene00022014", "G5EC93", "WBGene00022014", "O44616", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q9N309", "WBGene00022014", "O44827", "WBGene00019207", "Q23535", "WBGene00006865", "Q9XU83", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q23626", "WBGene00022014", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q19376", "WBGene00022014" ] }, "reaction_10604700": { "compartment": "compartment_7660", "id": "reaction_10604700", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604690", "species_30555" ], "products": [ "species_10604697", "species_113541" ], "modifiers": [ [ "species_10604690", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604684": { "compartment": "compartment_7660", "id": "reaction_10604684", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604676", "species_10604680" ], "products": [ "species_10604682" ], "modifiers": [], "additional_components": [ "WBGene00018721", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10604693": { "compartment": "compartment_7660", "id": "reaction_10604693", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604682", "species_29604" ], "products": [ "species_10604690", "species_113541" ], "modifiers": [ [ "species_10604682", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646366": { "compartment": "compartment_7660", "id": "reaction_10646366", "reactome": "R-CEL-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350" ], "products": [ "species_10646361", "species_10646363", "species_10646348" ], "modifiers": [ [ "species_10646350", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "WBGene00011216", "WBGene00011216", "WBGene00009441", "P34547", "WBGene00011216", "Q20059", "WBGene00009441" ] }, "reaction_10646089": { "compartment": "compartment_7660", "id": "reaction_10646089", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646066", "species_10646085" ], "products": [ "species_10646087" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10646359": { "compartment": "compartment_7660", "id": "reaction_10646359", "reactome": "R-CEL-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646350", "species_10646091" ], "products": [ "species_10646352" ], "modifiers": [], "additional_components": [ "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646338": { "compartment": "compartment_7660", "id": "reaction_10646338", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646329", "species_29358" ], "products": [ "species_113582", "species_10646335", "species_10604676" ], "modifiers": [ [ "species_10646329", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00018721", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646331": { "compartment": "compartment_7660", "id": "reaction_10646331", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646327", "species_10646311" ], "products": [ "species_10646329" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95QZ9", "WBGene00019121", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646333": { "compartment": "compartment_7660", "id": "reaction_10646333", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604697", "species_10646309" ], "products": [ "species_10646311" ], "modifiers": [], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "WBGene00011834", "Q22557", "WBGene00011834", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "G5EFY1", "WBGene00018721", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646357": { "compartment": "compartment_7660", "id": "reaction_10646357", "reactome": "R-CEL-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646352" ], "products": [ "species_10646350", "species_10646354", "species_10597874" ], "modifiers": [ [ "species_10646352", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "P34547", "WBGene00011216", "Q20059", "WBGene00009441", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "P34547", "WBGene00011216", "Q95Y97", "WBGene00019767", "Q20059", "WBGene00009441", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727" ] }, "reaction_10646094": { "compartment": "compartment_7660", "id": "reaction_10646094", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646087", "species_10597874" ], "products": [ "species_10646091", "species_10646085", "species_10604720" ], "modifiers": [ [ "species_10646087", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "Q22059", "WBGene00011318", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O44175", "WBGene00004338", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "Q17392", "WBGene00000839", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "Q23457", "WBGene00004320", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10648209": { "compartment": "compartment_7660", "id": "reaction_10648209", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648199" ], "products": [ "species_68454", "species_10648206", "species_10598267" ], "modifiers": [ [ "species_10648199", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296" ] }, "reaction_10648197": { "compartment": "compartment_7660", "id": "reaction_10648197", "reactome": "R-CEL-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10648186" ], "products": [ "species_10648194", "species_113541" ], "modifiers": [ [ "species_10648186", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648188": { "compartment": "compartment_7660", "id": "reaction_10648188", "reactome": "R-CEL-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10646054", "species_10648170", "species_10648180", "species_10598267" ], "products": [ "species_10648186" ], "modifiers": [], "additional_components": [ "Q9N4H4", "WBGene00004049", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "A0FLQ6", "WBGene00020964", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648202": { "compartment": "compartment_7660", "id": "reaction_10648202", "reactome": "R-CEL-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648194", "species_427523" ], "products": [ "species_10646052", "species_427497", "species_10648180", "species_10648199" ], "modifiers": [ [ "species_10648194", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049", "Q9N4H4", "WBGene00004049", "A0FLQ6", "WBGene00020964", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "A0FLQ6", "WBGene00020964", "Q9N3T2", "WBGene00000794", "O44199", "WBGene00004296", "Q9N4H4", "WBGene00004049" ] }, "reaction_10648173": { "compartment": "compartment_7660", "id": "reaction_10648173", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10648166" ], "products": [ "species_30555", "species_10648170" ], "modifiers": [ [ "species_10648166", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10621613": { "compartment": "compartment_876", "id": "reaction_10621613", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113", "species_188972", "species_114523" ], "products": [ "species_83910", "species_352022", "species_209914" ], "modifiers": [ [ "species_10621610", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10617035": { "compartment": "compartment_5460", "id": "reaction_10617035", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10599801", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10619309": { "compartment": "compartment_20699", "id": "reaction_10619309", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619299", "species_10619291", "species_10608669", "species_10619297" ], "products": [ "species_10614982", "species_10619307", "species_29372" ], "modifiers": [], "additional_components": [ "WBGene00001130", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "G5EFK4", "WBGene00000183", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "species_29438", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10619432": { "compartment": "compartment_70101", "id": "reaction_10619432", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10619307" ], "products": [ "species_10619299", "species_10619429", "species_10608669", "species_29372", "species_29420" ], "modifiers": [ [ "species_10619307", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00001130", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9N489", "WBGene00022453", "Q9XZI6", "WBGene00006751", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "O02495", "WBGene00004897", "Q02328", "WBGene00022717", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552", "WBGene00006791", "P34574", "WBGene00011867", "G5EBK2", "WBGene00014084", "Q93332", "WBGene00007954", "Q9GYJ9", "WBGene00004927", "O01755", "WBGene00000150", "P55326", "WBGene00008745", "O45718", "WBGene00000163", "Q9XZI6", "WBGene00006751", "Q9N489", "WBGene00022453", "G5EBE2", "WBGene00012868", "P51485", "WBGene00000195", "P35602", "WBGene00006829", "B1V8A0", "WBGene00006791", "Q02328", "WBGene00022717", "O02495", "WBGene00004897", "O44445", "WBGene00015327", "P91406", "WBGene00020082", "Q8I4E2", "WBGene00003086", "O16369", "WBGene00000159", "C6KRN3", "WBGene00012208", "Q8T874", "WBGene00000165", "D9PTP5", "WBGene00013354", "O17590", "WBGene00007620", "P39055", "WBGene00001130", "Q94057", "WBGene00044062", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "A0A486WXP9", "WBGene00001043", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q19767", "WBGene00004898", "G5EDY0", "WBGene00009552" ] }, "reaction_10614994": { "compartment": "compartment_70101", "id": "reaction_10614994", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10614982" ], "products": [ "species_10614986", "species_29420" ], "modifiers": [ [ "species_10614991", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "species_29438", "G5EFK4", "WBGene00000183", "WBGene00007703" ] }, "reaction_10659242": { "compartment": "compartment_876", "id": "reaction_10659242", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659237", "species_29356" ], "products": [ "species_29372", "species_10659239" ], "modifiers": [ [ "species_10659237", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", 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has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10659118", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659177": { "compartment": "compartment_876", "id": "reaction_10659177", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659167", "species_10659171", "species_10608681", "species_10659141", "species_10659143", "species_10659124", "species_10659159", "species_10659118" ], "products": [ "species_10658206", "species_10633167", "species_10659175" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "Q6AHQ8", "WBGene00018467", "WBGene00003086", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q19253", "WBGene00017298", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "Q9TXS0", "WBGene00018974", "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898" ] }, "reaction_10659192": { "compartment": "compartment_876", "id": "reaction_10659192", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633167", "species_10659116" ], "products": [ "species_10659118" ], "modifiers": [], "additional_components": [ "WBGene00009552", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EDY0", "WBGene00009552", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10659179": { "compartment": "compartment_876", "id": "reaction_10659179", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658240", "species_10659114" ], "products": [ "species_10659116" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "P0CG71", "WBGene00006727", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q19767", "WBGene00004898" ] }, "reaction_10658232": { "compartment": "compartment_876", "id": "reaction_10658232", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658218", "species_10658220", "species_10619297", "species_10658191", "species_10641905" ], "products": [ "species_10658224" ], "modifiers": [ [ "species_10658230", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "Q9BIF4", "WBGene00001224", "A0A0K3AS36", "Y116A8C.36d", "WBGene00022453", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10659190": { "compartment": "compartment_876", "id": "reaction_10659190", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10618288", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10658243": { "compartment": "compartment_876", "id": "reaction_10658243", "reactome": "R-CEL-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10658224", "species_113592" ], "products": [ "species_29370", "species_10658240" ], "modifiers": [ [ "species_10658224", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q9N4F3", "WBGene00000160", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q9BIF4", "WBGene00001224", "Q19123", "WBGene00000157", "Q20483", "WBGene00018516", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "species_179856", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10659244": { "compartment": "compartment_876", "id": "reaction_10659244", "reactome": "R-CEL-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10633129", "species_10659225" ], "products": [ "species_10659237" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659409": { "compartment": "compartment_876", "id": "reaction_10659409", "reactome": "R-CEL-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10659239" ], "products": [ "species_10659402", "species_29372" ], "modifiers": [ [ "species_10659239", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", 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"WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "O76667", "WBGene00019183", "P90961", "WBGene00020246", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", 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"O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659815": { "compartment": "compartment_876", "id": "reaction_10659815", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619297", "species_10641905", "species_179856" ], "products": [ "species_10658214" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N4F3", "WBGene00000160", "P90961", "WBGene00020246", "species_179856" ] }, "reaction_10659813": { "compartment": "compartment_24339", "id": "reaction_10659813", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659811" ], "products": [ "species_10659460", "species_10658191" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "species_29420", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "O17590", "WBGene00007620", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "P91857", "WBGene00004268", "Q9GYH7", "WBGene00004377", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "P34889", "WBGene00000858", "Q22227", "WBGene00003241", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "species_1806217", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q19019", "WBGene00004829", "Q8I4M6", "WBGene00007840", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "A0A486WXP9", "WBGene00001043", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "G5ECL2", "WBGene00006763", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "species_29420", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q9N532", "WBGene00003238", "Q9TXS0", "WBGene00018974", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "O17590", "WBGene00007620", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762" ] }, "reaction_10659221": { "compartment": "compartment_876", "id": "reaction_10659221", "reactome": "R-CEL-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659211", "species_10659207", "species_10659215", "species_10659175", "species_10659217", "species_10612328" ], "products": [ "species_10659219" ], "modifiers": [], "additional_components": [ "Q02328", "WBGene00022717", "species_113592", "P10984", "WBGene00000064", "Q02328", "WBGene00022717", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q19019", "WBGene00004829", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q19253", "WBGene00017298", "Q19123", "WBGene00000157", "Q03566", "WBGene00006576", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P58798", "WBGene00000204", "Q9XWV3", "WBGene00000203", "Q8WTM6", "WBGene00021170", "species_113592", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "Q9N4I0", "WBGene00000199", "A0A3P6PCS5", "WBGene00000201", "O61861", "WBGene00000205", "WBGene00007840", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10659227": { "compartment": "compartment_876", "id": "reaction_10659227", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10659223", "species_10659219" ], "products": [ "species_10659225" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064", "P29355", "WBGene00004774", "O18014", "WBGene00011381", "P91493", "WBGene00004924", "Q19625", "WBGene00003412", "Q9N489", "WBGene00022453", "P51485", "WBGene00000195", "G5EFK8", "WBGene00008779", "Q9U7D5", "WBGene00001519", "Q11124", "WBGene00015389", "O02495", "WBGene00004897", "Q09638", "WBGene00012084", "Q22227", "WBGene00003241", "P34889", "WBGene00000858", "Q17796", "WBGene00004101", "O16700", "WBGene00004925", "Q21948", "WBGene00020010", "O61861", "WBGene00000205", "A0A0K3AS36", "Y116A8C.36d", "Q19136", "WBGene00006306", "P39055", "WBGene00001130", "Q8WTM6", "WBGene00021170", "Q8I4M6", "WBGene00007840", "Q19019", "WBGene00004829", "A0A3P6PCS5", "WBGene00000201", "Q6AHQ8", "WBGene00018467", "P0CG71", "WBGene00006727", "Q21004", "WBGene00010272", "K8FE10", "WBGene00004922", "P34351", "WBGene00004899", "P90961", "WBGene00020246", "O76667", "WBGene00019183", "Q95XH1", "WBGene00022077", "Q95QV2", "WBGene00000477", "species_179856", "P90761", "WBGene00006777", "G5EBK2", "WBGene00014084", "P34574", "WBGene00011867", "Q9XZI6", "WBGene00006751", "P91439", "WBGene00020319", "Q18239", "WBGene00001102", "G5ECQ3", "WBGene00004762", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q9BIF4", "WBGene00001224", "Q02328", "WBGene00022717", "Q965S5", "WBGene00004923", "P34711", "WBGene00006756", "Q8I4E2", "WBGene00003086", "P53489", "WBGene00000200", "P91167", "WBGene00016729", "A0A0K3AUI8", "C34F11.9e", "Q20483", "WBGene00018516", "Q9TXS0", "WBGene00018974", "Q9N532", "WBGene00003238", "O01498", "WBGene00004109", "A0A486WXX8", "WBGene00000894", "Q22601", "WBGene00000161", "P35603", "WBGene00001082", "Q94057", "WBGene00044062", "P34693", "WBGene00004921", "Q9N4F3", "WBGene00000160", "Q9XTT3", "WBGene00013039", "Q9BI71", "WBGene00001329", "Q9N4I0", "WBGene00000199", "species_29438", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "Q19123", "WBGene00000157", "Q9XWV3", "WBGene00000203", "Q03566", "WBGene00006576", "species_113592", "O62189", "WBGene00009278", "Q6A573", "WBGene00021549", "Q9XUS7", "WBGene00010663", "Q19767", "WBGene00004898", "P10984", "WBGene00000064" ] }, "reaction_10644197": { "compartment": "compartment_70101", "id": "reaction_10644197", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10644194", "catalyst" ] ], "additional_components": [ "O01661", "WBGene00000368", "Q8MQA1", "WBGene00001187", "P34374", "WBGene00006772", "G5EG74", "WBGene00007041", "A0A078BQJ0", "WBGene00021125", "G5EDT2", "WBGene00007670", "G5EBI8", "WBGene00017400" ] }, "reaction_10644705": { "compartment": "compartment_70101", "id": "reaction_10644705", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10644685" ], "products": [ "species_29370", "species_10644703" ], "modifiers": [ [ "species_10604860", "catalyst" ] ], "additional_components": [ "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "WBGene00002189" ] }, "reaction_10619072": { "compartment": "compartment_204883", "id": "reaction_10619072", "reactome": "R-CEL-420598", "name": "Nectin-1:Nectin-4 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619068" ], "products": [ "species_10619070" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619066": { "compartment": "compartment_204883", "id": "reaction_10619066", "reactome": "R-CEL-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618975", "species_10611124" ], "products": [ "species_10619064" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10619062": { "compartment": "compartment_204883", "id": "reaction_10619062", "reactome": "R-CEL-420580", "name": "Nectin-1:PVRL3 trans heterodimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983", "species_10619058" ], "products": [ "species_10619060" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10640549": { "compartment": "compartment_876", "id": "reaction_10640549", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612994", "species_10640545" ], "products": [ "species_10640547" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247" ] }, "reaction_10614501": { "compartment": "compartment_984", "id": "reaction_10614501", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614495", "species_10614497" ], "products": [ "species_10614499" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10640887": { "compartment": "compartment_984", "id": "reaction_10640887", "reactome": "R-CEL-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10640883", "species_10631599" ], "products": [ "species_10640885" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "WBGene00006787", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q06561", "WBGene00006787", "Q21313", "WBGene00001328", "O44565", "WBGene00002247" ] }, "reaction_10614473": { "compartment": "compartment_984", "id": "reaction_10614473", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614469", "species_10614421" ], "products": [ "species_10614471" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10636750": { "compartment": "compartment_984", "id": "reaction_10636750", "reactome": "R-CEL-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10631430", "species_10636746" ], "products": [ "species_10636748" ], "modifiers": [], "additional_components": [ "P17139", "WBGene00001263", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44191", "WBGene00004374", "P17139", "WBGene00001263", "O44565", "WBGene00002247", "G5EFK8", "WBGene00008779" ] }, "reaction_10665322": { "compartment": "compartment_17938", "id": "reaction_10665322", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606876", "species_10665189" ], "products": [ "species_10665191" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665314": { "compartment": "compartment_17938", "id": "reaction_10665314", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606895", "species_10665178" ], "products": [ "species_10665189" ], "modifiers": [], "additional_components": [ "Q68TI8", "WBGene00000911", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665172": { "compartment": "compartment_17938", "id": "reaction_10665172", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165", "species_29420" ], "products": [ "species_29438", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665311": { "compartment": "compartment_17938", "id": "reaction_10665311", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665165" ], "products": [ "species_29372", "species_10665169" ], "modifiers": [ [ "species_10665165", "catalyst" ], [ "species_10665309", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "H2L0I8", "WBGene00020208", "S6FMZ4", "WBGene00017699" ] }, "reaction_10665185": { "compartment": "compartment_17938", "id": "reaction_10665185", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665180" ], "products": [ "species_10665178", "species_10665174" ], "modifiers": [], "additional_components": [ "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "Q23680", "WBGene00006918", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29468", "Q19425", "WBGene00008774" ] }, "reaction_10665187": { "compartment": "compartment_17938", "id": "reaction_10665187", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665174", "species_10665169" ], "products": [ "species_10665176" ], "modifiers": [], "additional_components": [ "species_29468", "Q19425", "WBGene00008774", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665183": { "compartment": "compartment_17938", "id": "reaction_10665183", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10665176" ], "products": [ "species_10665180", "species_29420" ], "modifiers": [ [ "species_10665176", "catalyst" ] ], "additional_components": [ "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "species_29468", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22494", "WBGene00020507", "C0HLB3", "WBGene00006911", "Q9XW92", "WBGene00013025", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "Q23680", "WBGene00006918", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "species_29420", "Q9XXU9", "WBGene00006920", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "B2MZD0", "WBGene00006916", "species_29468", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "Q19425", "WBGene00008774", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q22743", "WBGene00006414" ] }, "reaction_10665196": { "compartment": "compartment_17938", "id": "reaction_10665196", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10665191" ], "products": [ "species_10665193", "species_29372" ], "modifiers": [ [ "species_10665191", "catalyst" ] ], "additional_components": [ "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q19626", "WBGene00006921", "Q22743", "WBGene00006414", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "O17268", "WBGene00020101", "G5EGB3", "WBGene00012497", "species_29438", "Q8WQG5", "WBGene00007390", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P91040", "WBGene00015697", "P34462", "WBGene00010130", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P34443", "WBGene00010038", "Q22494", "WBGene00020507", "Q9XW92", "WBGene00013025", "Q23680", "WBGene00006918", "species_29420", "P30628", "WBGene00006768", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258", "Q95Q95", "WBGene00002583", "Q9N2U6", "WBGene00022402", "Q22743", "WBGene00006414", "Q19626", "WBGene00006921", "Q68TI8", "WBGene00000911", "C0HLB3", "WBGene00006911", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q8WQG5", "WBGene00007390", "species_29438", "G5EEK9", "WBGene00006914", "Q9XXU9", "WBGene00006920", "B2MZD0", "WBGene00006916", "P34462", "WBGene00010130", "P91040", "WBGene00015697", "C0HLB4", "WBGene00006912", "P91303", "WBGene00006919", "Q95X44", "WBGene00006917", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10665769": { "compartment": "compartment_7660", "id": "reaction_10665769", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649795" ], "products": [ "species_113582", "species_10649806", "species_113550" ], "modifiers": [ [ "species_10649795", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649828": { "compartment": "compartment_7660", "id": "reaction_10649828", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648541", "species_10598185", "species_10648539", "species_10649814" ], "products": [ "species_10649826" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "P0CG71", "WBGene00006727", "Q18547", "WBGene00004339", "P53016", "WBGene00004340", "Q18841", "WBGene00004337", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q19366", "WBGene00008722", "Q19196", "WBGene00017237", "P34409", "WBGene00017696", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q22798", "WBGene00020823", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "Q18547", "WBGene00004339", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "O44175", "WBGene00004338", "P53016", "WBGene00004340", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "P34429", "WBGene00018409", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q23088", "WBGene00022812", "Q19366", "WBGene00008722", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q21730", "WBGene00011016", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q9U2S6", "WBGene00000889", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q10051", "WBGene00020423", "Q86D18", "WBGene00010011", "Q9N4U0", "WBGene00021714", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "O62218", "WBGene00009368", "Q93338", "WBGene00007971", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "P90829", "WBGene00008645", "Q22798", "WBGene00020823" ] }, "reaction_10649798": { "compartment": "compartment_7660", "id": "reaction_10649798", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10649784" ], "products": [ "species_113582", "species_113550", "species_10649795" ], "modifiers": [ [ "species_10649784", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649812": { "compartment": "compartment_7660", "id": "reaction_10649812", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649808", "species_10604543" ], "products": [ "species_10649810" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649817": { "compartment": "compartment_7660", "id": "reaction_10649817", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649810" ], "products": [ "species_10649814" ], "modifiers": [ [ "species_10649810", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q93456", "WBGene00008665", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "Q17684", "WBGene00007355", "K8F7X5", "WBGene00013529", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "G5EBZ1", "WBGene00008140", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "Q22139", "WBGene00011411", "P52652", "WBGene00012000", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "Q95Y97", "WBGene00019767", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q93456", "WBGene00008665", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "G5EBZ1", "WBGene00008140", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10618987": { "compartment": "compartment_204883", "id": "reaction_10618987", "reactome": "R-CEL-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618983" ], "products": [ "species_10618985" ], "modifiers": [], "additional_components": [ "G5EG33", "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10621121": { "compartment": "compartment_876", "id": "reaction_10621121", "reactome": "R-CEL-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973" ], "products": [ "species_10618983" ], "modifiers": [], "additional_components": [ "WBGene00001863", "G5EG33", "WBGene00001863" ] }, "reaction_10618981": { "compartment": "compartment_70101", "id": "reaction_10618981", "reactome": "R-CEL-419003", "name": "Interaction of Nectins with Afadin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618973", "species_10618971" ], "products": [ "species_10618979" ], "modifiers": [], "additional_components": [ "WBGene00001863", "WBGene00021009", "Q86NJ4", "WBGene00021009", "G5EG33", "WBGene00001863" ] }, "reaction_10619084": { "compartment": "compartment_20699", "id": "reaction_10619084", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617173" ], "products": [ "species_10619076", "species_10617114" ], "modifiers": [ [ "species_10619081", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10617118": { "compartment": "compartment_70101", "id": "reaction_10617118", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617114" ], "products": [ "species_10617116" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10617166": { "compartment": "compartment_70101", "id": "reaction_10617166", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601197" ], "products": [ "species_29370", "species_10617163" ], "modifiers": [ [ "species_10617139", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10617156": { "compartment": "compartment_12045", "id": "reaction_10617156", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617148" ], "products": [ "species_29370", "species_10617153" ], "modifiers": [ [ "species_10617148", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10617158": { "compartment": "compartment_12045", "id": "reaction_10617158", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617146" ], "products": [ "species_10617148" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10628857": { "compartment": "compartment_70101", "id": "reaction_10628857", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628845" ], "products": [ "species_10628851" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10628923": { "compartment": "compartment_7660", "id": "reaction_10628923", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628851", "species_10628892" ], "products": [ "species_10628894" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00000095", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639875": { "compartment": "compartment_70101", "id": "reaction_10639875", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639873", "species_10639871" ], "products": [ "species_10639772" ], "modifiers": [], "additional_components": [ "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O16303", "WBGene00001037", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030" ] }, "reaction_10617141": { "compartment": "compartment_12045", "id": "reaction_10617141", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130" ], "products": [ "species_10617139" ], "modifiers": [], "additional_components": [ "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970", "Q9NAK3", "WBGene00012586", "Q19192", "WBGene00003970" ] }, "reaction_10628905": { "compartment": "compartment_7660", "id": "reaction_10628905", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10628899", "species_10628894", "species_10628901", "species_29428" ], "products": [ "species_10628903" ], "modifiers": [], "additional_components": [ "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10639777": { "compartment": "compartment_70101", "id": "reaction_10639777", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10639772" ], "products": [ "species_10639774", "species_29372" ], "modifiers": [ [ "species_10639772", "catalyst" ], [ "species_10639770", "catalyst" ] ], "additional_components": [ "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_29370", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "G5EC99", "WBGene00008714", "P09446", "WBGene00002005", "species_113592", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "O45502", "WBGene00001030" ] }, "reaction_10617181": { "compartment": "compartment_12045", "id": "reaction_10617181", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617177" ], "products": [ "species_10617171" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10665100": { "compartment": "compartment_876", "id": "reaction_10665100", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615353", "species_9634838" ], "products": [ "species_10615363" ], "modifiers": [], "additional_components": [ "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "O01302", "WBGene00011362", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "Q21266", "WBGene00019477", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "LigandDisplayForward?ligandId=8994", "O01302", "WBGene00011362", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q23268", "WBGene00013873", "Q22008", "WBGene00020125", "LigandDisplayForward?ligandId=6687", "P92016", "WBGene00011364", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "H2L0K7", "WBGene00020330", "Q9XW75", "WBGene00013540", "Q8MQ23", "WBGene00010116", "G5EDJ7", "WBGene00013875", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "LigandDisplayForward?ligandId=9074", "Q21266", "WBGene00019477" ] }, "reaction_10615850": { "compartment": "compartment_984", "id": "reaction_10615850", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10615808", "catalyst" ] ], "additional_components": [ "Q9XXQ4", "WBGene00022348", "G5EGL6", "WBGene00022348", "Q9U539", "WBGene00003842", "G5EDA7", "WBGene00022348", "Q22686", "WBGene00022348", "Q9BI47", "WBGene00022348", "G5EDU0", "WBGene00003837", "G5EC34", "WBGene00022348", "G4S3P8", "WBGene00006220", "P91993", "WBGene00022348", "Q7Z118", "WBGene00022348", "Q10917", "WBGene00022348", "Q9BKR9", "WBGene00022348", "A0A0K3AWD3", "WBGene00022348" ] }, "reaction_10660314": { "compartment": "compartment_13946", "id": "reaction_10660314", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660280" ], "products": [ "species_10659955", "species_10660290", "species_29420" ], "modifiers": [ [ "species_10660311", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9UAQ6", "WBGene00004266", "Q9BKQ5", "WBGene00022051", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29438", "Q5WRR4", "WBGene00016614", "Q20100", "WBGene00018088", "B1GRL5", "WBGene00077643", "Q95QQ2", "WBGene00016964", "G4SNB8", "WBGene00044604", "Q93330", "WBGene00007956", "Q9XU81", "WBGene00010699", "B1V899", "WBGene00022138", "Q9NA81", "WBGene00013259", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "O02173", "WBGene00021046" ] }, "reaction_10659968": { "compartment": "compartment_216813", "id": "reaction_10659968", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10659957" ], "products": [ "species_10659955", "species_10659961", "species_29420" ], "modifiers": [ [ "species_10659965", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q94986", "WBGene00004267", "Q20759", "WBGene00010045", "O02626", "WBGene00000086" ] }, "reaction_10660750": { "compartment": "compartment_70101", "id": "reaction_10660750", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660324", "species_113592" ], "products": [ "species_29370", "species_10660745" ], "modifiers": [ [ "species_10610909", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102" ] }, "reaction_10660061": { "compartment": "compartment_437051", "id": "reaction_10660061", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660045" ], "products": [ "species_10660049", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660054", "catalyst" ] ], "additional_components": [ "species_29420", "Q94148", "WBGene00004273", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10660203": { "compartment": "compartment_171062", "id": "reaction_10660203", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660192" ], "products": [ "species_10660196", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660198", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q22045", "WBGene00004279", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10660096": { "compartment": "compartment_263163", "id": "reaction_10660096", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660085" ], "products": [ "species_10659955", "species_10660093", "species_29420" ], "modifiers": [ [ "species_10657253", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10660170": { "compartment": "compartment_70101", "id": "reaction_10660170", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660154" ], "products": [ "species_10660158", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660167", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29438", "Q93874", "WBGene00004276", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10660377": { "compartment": "compartment_20699", "id": "reaction_10660377", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660361" ], "products": [ "species_10660367", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660372", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29438", "Q18969", "WBGene00004286", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10660123": { "compartment": "compartment_262783", "id": "reaction_10660123", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660114" ], "products": [ "species_10659955", "species_10660118", "species_29420" ], "modifiers": [ [ "species_10660120", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "U4PBM1", "WBGene00018681" ] }, "reaction_10660329": { "compartment": "compartment_262783", "id": "reaction_10660329", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660318", "species_29438" ], "products": [ "species_10660322", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660324", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10660406": { "compartment": "compartment_12045", "id": "reaction_10660406", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660393" ], "products": [ "species_10660397", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10660403", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q8MXS1", "WBGene00004277", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22670", "WBGene00004318", "Q93538", "WBGene00004317" ] }, "reaction_10660150": { "compartment": "compartment_204883", "id": "reaction_10660150", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660141" ], "products": [ "species_10659955", "species_29420", "species_10660145" ], "modifiers": [ [ "species_10660147", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375" ] }, "reaction_10660245": { "compartment": "compartment_5668575", "id": "reaction_10660245", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660232" ], "products": [ "species_10660242", "species_10659955", "species_29420" ], "modifiers": [ [ "species_10645717", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29438", "G5EBS5", "WBGene00000089", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10660272": { "compartment": "compartment_17938", "id": "reaction_10660272", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660249" ], "products": [ "species_10659955", "species_10660255", "species_29420" ], "modifiers": [ [ "species_10660269", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q23146", "WBGene00004271", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "Q23146", "WBGene00004271", "Q9BI89", "WBGene00018321", "Q9XVL8", "WBGene00010283" ] }, "reaction_10660081": { "compartment": "compartment_263163", "id": "reaction_10660081", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10660065" ], "products": [ "species_10659955", "species_10660071", "species_29420" ], "modifiers": [ [ "species_10660078", "catalyst" ] ], "additional_components": [ "species_29420", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29438", "G5EFC1", "WBGene00004272", "Q7K7A5", "WBGene00004375", "Q20759", "WBGene00010045" ] }, "reaction_10660110": { "compartment": "compartment_70101", "id": "reaction_10660110", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10660103", "species_113592" ], "products": [ "species_29370", "species_10660107" ], "modifiers": [ [ "species_10646852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "A0A3P6NNZ8", "WBGene00020324", "Q23023", "WBGene00006786" ] }, "reaction_10620770": { "compartment": "compartment_70101", "id": "reaction_10620770", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620766", "species_10620720", "species_10620753" ], "products": [ "species_10620768" ], "modifiers": [], "additional_components": [ "species_113592", "P10984", "WBGene00000064", "WBGene00022048", "WBGene00006999", "U4PBJ9", "WBGene00022048", "species_113592", "P10984", "WBGene00000064", "Q9U3F4", "WBGene00006999" ] }, "reaction_10622043": { "compartment": "compartment_984", "id": "reaction_10622043", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614445", "species_10622041" ], "products": [ "species_10621032" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10622187": { "compartment": "compartment_70101", "id": "reaction_10622187", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620753", "species_10622183" ], "products": [ "species_10622185" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621040": { "compartment": "compartment_984", "id": "reaction_10621040", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621036", "species_10621032" ], "products": [ "species_10621038" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10620762": { "compartment": "compartment_70101", "id": "reaction_10620762", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620758", "species_10620753" ], "products": [ "species_10620760" ], "modifiers": [], "additional_components": [ "WBGene00006836", "WBGene00006999", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10621020": { "compartment": "compartment_70101", "id": "reaction_10621020", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612261", "species_10621016" ], "products": [ "species_10621018" ], "modifiers": [], "additional_components": [ "WBGene00003930", "WBGene00003931", "Q9TZC4", "WBGene00003931", "Q27874", "WBGene00003930" ] }, "reaction_10622206": { "compartment": "compartment_70101", "id": "reaction_10622206", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622200", "species_10621016", "species_10622198" ], "products": [ "species_10622204" ], "modifiers": [], "additional_components": [ "O16785", "WBGene00003932", "WBGene00003931", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "O16785", "WBGene00003932", "Q19157", "WBGene00004030", "P50464", "WBGene00006826", "Q9TZC4", "WBGene00003931" ] }, "reaction_10622039": { "compartment": "compartment_70101", "id": "reaction_10622039", "reactome": "R-CEL-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622035", "species_10621038" ], "products": [ "species_10622037" ], "modifiers": [], "additional_components": [ "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930", "P34285", "WBGene00006627", "Q18823", "WBGene00016913", "A0A1N7SYP3", "WBGene00006876", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q03600", "WBGene00002081", "O44565", "WBGene00002247", "Q27874", "WBGene00003930" ] }, "reaction_10621024": { "compartment": "compartment_70101", "id": "reaction_10621024", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614419", "species_10611919" ], "products": [ "species_10621022" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10609990": { "compartment": "compartment_876", "id": "reaction_10609990", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609944", "species_10609939" ], "products": [ "species_10609988" ], "modifiers": [], "additional_components": [ "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064", "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10609992": { "compartment": "compartment_70101", "id": "reaction_10609992", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609988" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P34574", "WBGene00011867", "P35603", "WBGene00001082", "P39055", "WBGene00001130", "P90961", "WBGene00020246", "A0A486WXX8", "WBGene00000894", "P10984", "WBGene00000064" ] }, "reaction_10603861": { "compartment": "compartment_7660", "id": "reaction_10603861", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10603858" ], "products": [ "species_113582", "species_10603854" ], "modifiers": [ [ "species_10603858", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O17245", "WBGene00018769", "Q17558", "WBGene00015296", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10605290": { "compartment": "compartment_7660", "id": "reaction_10605290", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603858" ], "products": [ "species_10603858" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q8MYM8", "WBGene00012694", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "Q17558", "WBGene00015296", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10609645": { "compartment": "compartment_984", "id": "reaction_10609645", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609687": { "compartment": "compartment_984", "id": "reaction_10609687", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10609684", "catalyst" ] ], "additional_components": [ "Q9TZA0", "WBGene00017103", "Q18758", "WBGene00016848" ] }, "reaction_10609670": { "compartment": "compartment_984", "id": "reaction_10609670", "reactome": "R-CEL-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10646409": { "compartment": "compartment_984", "id": "reaction_10646409", "reactome": "R-CEL-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609994": { "compartment": "compartment_984", "id": "reaction_10609994", "reactome": "R-CEL-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10609690": { "compartment": "compartment_984", "id": "reaction_10609690", "reactome": "R-CEL-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10650244": { "compartment": "compartment_984", "id": "reaction_10650244", "reactome": "R-CEL-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786438", "species_109276" ], "products": [ "species_6786428", "species_6786426" ], "modifiers": [ [ "species_10650241", "catalyst" ] ], "additional_components": [ "species_1678743", "WBGene00021252" ] }, "reaction_10609998": { "compartment": "compartment_984", "id": "reaction_10609998", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189071", "species_109276" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10609642", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10609697": { "compartment": "compartment_984", "id": "reaction_10609697", "reactome": "R-CEL-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10610000": { "compartment": "compartment_984", "id": "reaction_10610000", "reactome": "R-CEL-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10609694", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895" ] }, "reaction_10609996": { "compartment": "compartment_984", "id": "reaction_10609996", "reactome": "R-CEL-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10609667", "catalyst" ] ], "additional_components": [ "Q21750", "WBGene00019895", "Q19004", "WBGene00017071" ] }, "reaction_10648681": { "compartment": "compartment_7660", "id": "reaction_10648681", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10648674" ], "products": [ "species_113582", "species_113550", "species_10648678" ], "modifiers": [ [ "species_10648674", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q95PZ4", "WBGene00013441", "P0CG71", "WBGene00006727", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648331": { "compartment": "compartment_7660", "id": "reaction_10648331", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648306", "species_10648325" ], "products": [ "species_10601816", "species_10648329" ], "modifiers": [], "additional_components": [ "WBGene00006963", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q21302", "WBGene00006963", "P34567", "WBGene00011814", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10648692": { "compartment": "compartment_7660", "id": "reaction_10648692", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10648689", "species_30555" ], "products": [ "species_10648685", "species_113541" ], "modifiers": [ [ "species_10648689", "catalyst" ] ], "additional_components": [ "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823", "Q18547", "WBGene00004339", "Q19366", "WBGene00008722", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "Q19196", "WBGene00017237", "O62218", "WBGene00009368", "Q21730", "WBGene00011016", "O44175", "WBGene00004338", "P0CG71", "WBGene00006727", "P53016", "WBGene00004340", "P34409", "WBGene00017696", "Q18841", "WBGene00004337", "P90829", "WBGene00008645", "P34429", "WBGene00018409", "Q22798", "WBGene00020823" ] }, "reaction_10648687": { "compartment": "compartment_7660", "id": "reaction_10648687", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601853", "species_10648323" ], "products": [ "species_10648325" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "Q11083", "WBGene00015264", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "Q23451", "WBGene00013924", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296", "P0CG71", "WBGene00006727", "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q11083", "WBGene00015264", "Q9N390", "WBGene00021904", "Q21554", "WBGene00010890", "A0A2C9C3L3", "WBGene00015264", "K8F7X5", "WBGene00013529", "Q23451", "WBGene00013924", "P0CG71", "WBGene00006727", "Q95PZ4", "WBGene00013441", "P30644", "WBGene00015264", "Q17392", "WBGene00000839", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N4H4", "WBGene00004049", "Q23457", "WBGene00004320", "Q9N4C3", "WBGene00022296" ] }, "reaction_10604545": { "compartment": "compartment_7660", "id": "reaction_10604545", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604541", "species_10604536" ], "products": [ "species_10604543" ], "modifiers": [], "additional_components": [ "WBGene00008140", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10637467": { "compartment": "compartment_876", "id": "reaction_10637467", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614508", "species_10637463" ], "products": [ "species_10637465" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10637471": { "compartment": "compartment_984", "id": "reaction_10637471", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614487", "species_10636719" ], "products": [ "species_10637469" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18096", "WBGene00007687", "Q5ZR75", "WBGene00020516", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636627": { "compartment": "compartment_876", "id": "reaction_10636627", "reactome": "R-CEL-2396395", "name": "HSPG2 (perlecan) binds alpha-dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636623", "species_10631599" ], "products": [ "species_10636625" ], "modifiers": [], "additional_components": [ "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "WBGene00006787", "Q22629", "WBGene00000961", "Q06561", "WBGene00006787", "O61756", "WBGene00018943" ] }, "reaction_10636875": { "compartment": "compartment_984", "id": "reaction_10636875", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10636871", "species_10636867" ], "products": [ "species_10636873" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "WBGene00002247", "Q10651", "WBGene00000149", "O44565", "WBGene00002247" ] }, "reaction_10649760": { "compartment": "compartment_7660", "id": "reaction_10649760", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649737", "species_10597874" ], "products": [ "species_10649757" ], "modifiers": [ [ "species_10649737", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10649741": { "compartment": "compartment_7660", "id": "reaction_10649741", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649724", "species_10649716" ], "products": [ "species_10649726" ], "modifiers": [], "additional_components": [ "WBGene00010011", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011" ] }, "reaction_10649787": { "compartment": "compartment_7660", "id": "reaction_10649787", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10649778" ], "products": [ "species_10649784", "species_10597874" ], "modifiers": [ [ "species_10649778", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320", "WBGene00006727", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34545", "WBGene00000366", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q7JKC3", "WBGene00010406", "Q965S0", "WBGene00022400", "Q21302", "WBGene00006963", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q10051", "WBGene00020423", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "Q23088", "WBGene00022812", "Q20716", "WBGene00009966", "P91175", "WBGene00016837", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P0CG71", "WBGene00006727", "Q9U1Q7", "WBGene00001258", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q9U2S6", "WBGene00000889", "P52652", "WBGene00012000", "Q22139", "WBGene00011411", "Q23457", "WBGene00004320" ] }, "reaction_10649714": { "compartment": "compartment_7660", "id": "reaction_10649714", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10601853", "species_10599971" ], "products": [ "species_10649712" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O17245", "WBGene00018769", "P34567", "WBGene00011814", "K8F7X5", "WBGene00013529", "G5EFV5", "WBGene00000408", "Q95PZ4", "WBGene00013441", "Q9U3I0", "WBGene00009078", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "Q9GR61", "WBGene00021347", "O02092", "WBGene00018391", "Q17684", "WBGene00007355", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q9N3C9", "WBGene00021845", "Q9N5K2", "WBGene00019246", "Q9XVH6", "WBGene00012187", "Q19826", "WBGene00017830", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649719": { "compartment": "compartment_7660", "id": "reaction_10649719", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10649712" ], "products": [ "species_113541", "species_10649716" ], "modifiers": [ [ "species_10649712", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187" ] }, "reaction_10649739": { "compartment": "compartment_7660", "id": "reaction_10649739", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649735", "species_10649726" ], "products": [ "species_10648738", "species_10649737" ], "modifiers": [], "additional_components": [ "Q17392", "WBGene00000839", "Q18963", "WBGene00008403", "Q9N425", "WBGene00000815", "Q21554", "WBGene00010890", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q23457", "WBGene00004320", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q9U3I0", "WBGene00009078", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N4U0", "WBGene00021714", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q9N5K2", "WBGene00019246", "Q19826", "WBGene00017830", "Q95PZ4", "WBGene00013441", "Q93338", "WBGene00007971", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N3L2", "WBGene00021752", "Q18963", "WBGene00008403", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "O02092", "WBGene00018391", "Q21554", "WBGene00010890", "P16356", "WBGene00000123", "Q10578", "WBGene00016140", "Q9N5K2", "WBGene00019246", "Q95PZ4", "WBGene00013441", "Q965S0", "WBGene00022400", "O17245", "WBGene00018769", "Q9GR61", "WBGene00021347", "P34567", "WBGene00011814", "G5EFV5", "WBGene00000408", "Q9N3C9", "WBGene00021845", "Q9XVH6", "WBGene00012187", "Q86D18", "WBGene00010011", "Q9U3I0", "WBGene00009078", "Q9N4U0", "WBGene00021714", "K8F7X5", "WBGene00013529", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "Q17392", "WBGene00000839", "Q93338", "WBGene00007971", "Q23457", "WBGene00004320" ] }, "reaction_10637202": { "compartment": "compartment_984", "id": "reaction_10637202", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255" ], "products": [ "species_10612257" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769" ] }, "reaction_10636530": { "compartment": "compartment_876", "id": "reaction_10636530", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612255", "species_10612265" ], "products": [ "species_10636528" ], "modifiers": [], "additional_components": [ "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "species_266099", "P34446", "WBGene00003929", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10657257": { "compartment": "compartment_20699", "id": "reaction_10657257", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10657247", "species_10657253" ], "products": [ "species_10657255" ], "modifiers": [], "additional_components": [ "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q7YWW8", "WBGene00010815", "Q20365", "WBGene00004283", "species_29438", "Q09417", "WBGene00011071" ] }, "reaction_10656786": { "compartment": "compartment_20699", "id": "reaction_10656786", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10656782" ], "products": [ "species_10656784" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q95XZ0", "WBGene00021784", "O44502", "WBGene00019820", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "O18230", "WBGene00013302", "Q6AW08", "WBGene00022121", "Q20797", "WBGene00006373", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "P41941", "WBGene00007128", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305" ] }, "reaction_10657525": { "compartment": "compartment_20699", "id": "reaction_10657525", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10656221", "species_10657521" ], "products": [ "species_10657523" ], "modifiers": [], "additional_components": [ "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "P34213", "WBGene00004269", "species_29438", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "Q22782", "WBGene00004270", "P91151", "WBGene00016608", "Q21444", "WBGene00000585", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "Q21270", "WBGene00019481", "P34213", "WBGene00004269", "species_29438", "G5EE66", "WBGene00003258", "Q18773", "WBGene00016874", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "O44502", "WBGene00019820", "Q22782", "WBGene00004270" ] }, "reaction_10657238": { "compartment": "compartment_20699", "id": "reaction_10657238", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10649229", "species_10649213", "species_10657234" ], "products": [ "species_10657236" ], "modifiers": [], "additional_components": [ "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q94392", "WBGene00003818", "Q95ZW1", "WBGene00017273", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "Q18921", "WBGene00017016", "Q1RPT8", "WBGene00044794", "Q9NEQ8", "WBGene00044794", "Q20797", "WBGene00006373", "Q9TXZ9", "WBGene00015164", "Q94392", "WBGene00003818" ] }, "reaction_10623845": { "compartment": "compartment_876", "id": "reaction_10623845", "reactome": "R-CEL-532603", "name": "Nephrin mediated activation of N-WASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615464" ], "products": [ "species_10615466" ], "modifiers": [], "additional_components": [ "WBGene00018215", "Q9TXI8", "WBGene00018215" ] }, "reaction_10636526": { "compartment": "compartment_984", "id": "reaction_10636526", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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